ROS/NO/O2

1a. Introduction: Background

• Dan Wang, M.D., Ph.D.• Christopher Wilcox, M.D., Ph.D.• Sven Strangaard, Ph.D.• Shakil Aslam, M.D.

ENDOTHELIAL FUNCTION OF SUBDERMAL MICROVESSELS, PLASMA ADMA AND ROS MARKERS IN PATIENTS WITH CHRONIC KIDNEY DISEASE STAGE 1 OR EARLY ESSENTIAL HYPERTENSION

CONCLUSIONS

• Humans with essential hypertension or CKD-1 have:– reduced

microvascular EDRF and NOS

– increased circulating ADMA

– oxidative stress