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PROJECT FINAL REPORT
Annex to Final Report
GRANT AGREEMENT NUMBER: 278850
PROJECT ACRONYM: INMIND
PROJECT TITLE: IMAGING OF NEUROINFLAMMATION IN NEURODEGENERATIVE DISEASES
FUNDING SCHEME: LARGE SCALE COLLABORATIVE PROJECT
DATE OF LATEST VERSION OF ANNEX I AGAINST WHICH THE ASSESSMENT WILL BE MADE: 2014/11/28
PERIOD COVERED: FROM MARCH 1ST 2012 TO FEBRUARY 28TH 2017
NAME, TITLE AND ORGANISATION OF THE SCIENTIFIC REPRESENTATIVE OF THE PROJECT'S COORDINATOR: PROF. DR. MED. ANDREAS H. JACOBS EUROPEAN INSTITUTE FOR MOLECULAR IMAGING (EIMI) WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER (WWU) WALDEYERSTR.15 D-48149 MÜNSTER
TEL: +49 251 83 49300 FAX: +49 251 83 49313 E-MAIL: [email protected] PROJECT WEBSITE ADDRESS: http://www.inmind-project.eu
1
1
Content
Content _______________________________________________________________________________________ 1 1 List of partners ______________________________________________________________________________ 2 2 Figure _____________________________________________________________________________________ 3 3 Use and dissemination of foreground ___________________________________________________________ 4 3.1 Section C – Work performed _________________________________________________________________ 4 3.1.1 Work performed ________________________________________________________________________ 4 3.1.2 IP developed __________________________________________________________________________ 10 3.2 Section D – Training & Education _____________________________________________________________ 13 3.2.1 Training ______________________________________________________________________________ 13 3.2.2 Thesis _______________________________________________________________________________ 15 3.2.3 Exchange of personnel __________________________________________________________________ 20 4 List of abbreviations ________________________________________________________________________ 21
1 List of partners
Table 1: List of partners.
Part. no Short name Principle investigator Participant short name Country Participation (month)
Academic institutions 1 WWU JACOBS, Andreas H. (MD), Co WW University of Münster DE 1-60 2 UMIL MAGGI, Adriana (PhD) University of Milano IT 1-60 3 PMU AIGNER, Ludwig (PhD) Paracelsus Medical
University, Salzburg AT 1-60
4 UT GUILLOTEAU, Denis (PhD) University of Tours FR 1-60 5 UniTo AIMIE, Silvio (PhD) University of Torino IT 1-60 6 IDIBAPS PLANAS, Anna (PhD) University of Barcelona ES 1-60 7 UA VAN DER LINDEN, Annemie (PhD) University of Antwerp BE 1-60 8 CEA DOLLÉ, Frédéric (PhD) CEA, Orsay FR 1-60 9/31 VUA/VU-VUmc LAMMERTSMA, Adriaan (PhD) VU Univ. Medical Centre,
Amsterdam NL 1-60
10a 10b
UNIMAN HERHOLZ, Karl (MD) BOUTIN, Hervé (PhD)
University of Manchester UK 1-60 1-60
11 USR PERANI, Daniela (MD, PhD) V-S San Raffaele University, Milano
IT 1-60
12a 12b
KI HALLDIN, Christer (PhD) NORDBERG, Agneta (MD, PhD)
Karolinska Institute, Stockholm
SE 1-60
13a 13b
KUL VAN LAERE, Koen (MD, PhD) BAEKELANDT, Veerle (PhD)
University of Leuven BE 1-60
14 RH-NRU KNUDSEN, Gitte (MD, PhD) University of Copenhagen DK 1-60 15 CNR-IBB PAPPATA, Sabina (MD, PhD) National Research Council,
Naples IT 1-60
16 Turku UH RINNE, Juha (MD, PhD) University of Turku FI 1-60 17 USOTON HOLMES, Clive (MD, PhD) University of Southampton UK 1-60 18a 18b
IMPERIAL RONCAROLI, Federico (PhD) BROOKS, David (PhD)
Imperial College, London UK 1-48 1-60
19 UNSYD KASSIOU, Michael (PhD) University of Sydney AU 1-60 20 SE KELLERMAYER, Miklós (MD, PhD) Semmelweis University,
Budapest HU 1-60
21 UKB HENEKA, Michael (MD) University of Bonn Medical Centre
DE 1-60
30 UniParis TAVITIAN, Bertrand (MD, PhD) University Paris Descartes DE 13-60 SMEs 22 TOP RONCORONI, Chiara (PhD) Transgenic Operative
Products Srl, Lodi IT 1-24
23 BV-CYCLO FUNKE, Uta (PhD) BV-CYCLOTRON, Amsterdam
NL 1-60
24 CAGE CAVALLOTTI, Camilla (PhD) CAGE Chemicals Srl, Novara IT 1-60 25 Pharmidex ALAVIJEH, Mohammad (PhD) Pharmidex Pharmaceuticals,
London UK 1-60
26 MEDISO PAPP, László (PhD) Medical Imaging Systems, Budapest
HU 1-60
27 NeuroSearch RøNN, Lars Christian (PhD) NeuroSearch AS, Ballerup DK 1-12 28 Aniona CHRISTOPHERSEN, Palle (PhD) Aniona APS, Ballerup DK 13-60
2 Figure
Figure 1: INMiND translational and reverse-translational strategy.
3 U
se a
nd d
isse
min
atio
n of
fore
grou
nd
3.1
Sect
ion
C –
Wor
k pe
rfor
med
3.
1.1
Wor
k pe
rfor
med
Ta
ble 2:
Lis
t of P
ET tr
acer
stud
ies.
Trac
ers
type
of a
nim
al m
odel
type
of a
nim
al st
udy
type
of h
uman
pat
holo
gy
type
of h
uman
stud
y As
trocy
te tr
acer
s, es
tabl
ished
trac
ers
[11C]
Deute
rium-
L-De
pren
yl Tg
2576
AD
mous
e mod
el mo
del c
hara
cteris
ation
au
tosom
al do
mina
nt an
d spo
radic
AD
patie
nts, c
ognit
ive di
scor
dant
AD tw
ins, M
CI
disea
se ch
arac
terisa
tion
relat
e sign
al to
PIB
signa
l Am
yloid
trac
ers,
esta
blish
ed tr
acer
s [11
C]PI
B Tg
2576
mou
se A
D mo
del
mode
l cha
racte
risati
on
(F)A
D an
d MCI
pati
ents
insuli
n res
istan
t pts
at ris
k for
cogn
itive i
mpair
ment
and
deme
ntia
relat
e PIB
sign
al to
NE40
, DED
, PBR
28 or
DP
A-71
4 sign
al
[18F]
Flutem
etamo
l ([18
F]PI
B)
APP2
3 mou
se m
odel
Tg25
76 m
ouse
mod
el AP
Pswe
/PS1
dE9 m
ouse
mod
el
mode
l cha
racte
risati
on
AD pa
tients
(auto
soma
l dom
inant
and
spor
adic
AD pa
tients
) and
MCI
healt
hy
volun
teers
disea
se ch
arac
terisa
tion
[18F]
florb
etapir
(Amy
vid)
MCI, A
D pa
tients
and h
ealth
y volu
nteer
s tes
t-rete
st re
peata
bility
tria
l pati
ent s
electi
on
Amylo
id tr
acer
s, ne
w tra
cers
valid
ated
[18
F]AV
-45
APPs
swe/P
S1dE
9 mou
se m
odel
mode
l cha
racte
risati
on
[18F]
AV-0
1 Tg
F334
-AD
rats
mode
l cha
racte
risati
on
[18F]
FDDN
P AP
Pswe
/PSE
N1 A
D mo
use m
odel
and W
T ph
arma
cokin
etic p
aram
etric
map c
onstr
uctio
n
[11
C]AZ
D218
4 Tg
2576
AD
mice
mo
del c
hara
cteris
ation
Mi
crog
lia tr
acer
s (TS
PO),
esta
blish
ed tr
acer
s (R
)-[11
C]PK
1119
5 QA
rat m
odel
of NI
AP
Pswe
/PS1
dE9 m
ouse
AD
mode
l foc
al ra
t MS
mode
l LP
S ra
t mod
el
direc
t com
paris
on w
ith D
PA-7
14 or
GE-
180
treatm
ent fo
llow-
up (P
PAR-
gamm
a ago
nist in
AD
) tra
cer q
uanti
ficati
on
healt
hy vo
luntee
rs mu
ltiple
syste
m atr
ophy
str
oke b
rain
tumor
patie
nts (lo
w gr
ade a
nd
trans
formi
ng gl
iomas
) psy
chos
is pa
tients
sc
hizop
hren
ia pa
tients
pres
ympto
matic
HD
gene
carri
ers S
OD1 A
LS pa
tients
and
carri
ers A
D an
d MCI
(incl.
amne
stic a
nd
multi-
doma
in) A
POEe
4 car
riers
and n
on
carri
ers F
atal F
amilia
l Inso
mnia
carri
ers
SPMS
and R
RMS
patie
nts
trace
r qua
ntific
ation
no
rmal
datab
ase
direc
t com
paris
on w
ith G
E-18
0 (MS
A,
strok
e)
disea
se ch
arac
terisa
tion
treatm
ent fo
llow-
up
[123I]
CLIN
DE
traum
atic b
rain
injur
y rat
mode
l mo
del c
hara
cteris
ation
he
althy
volun
teers
gliom
ablas
toma p
atien
ts str
oke p
atien
ts MS
patie
nts au
toimm
une
ence
phali
tis pa
tients
proo
f-of-p
rincip
le tes
t-rete
st va
riabil
ity
pred
icting
/mon
itorin
g tum
or/di
seas
e pr
ogre
ssion
[12
5I]CL
INME
Tg
F334
-AD
rats
asph
yxia
rat m
odel
mode
l cha
racte
risati
on
[11C]
PBR2
8 CX
3CR1
Cre-
ERxR
osa2
6-DT
A mo
use m
odel
for m
icrog
lia de
pletio
n AP
P/PS
1-21
mou
se A
D mo
del
mode
l cha
racte
risati
on
trace
r qua
ntific
ation
, test-
retes
t var
iabilit
y he
althy
volun
teers
MS pa
tients
PD
patie
nts
test-r
etest
varia
bility
tra
cer q
uanti
ficati
on
treatm
ent fo
llow
up (F
ingoli
mod o
r
Trac
ers
type
of a
nim
al m
odel
type
of a
nim
al st
udy
type
of h
uman
pat
holo
gy
type
of h
uman
stud
y AP
Pswe
/PS1
dE91
mou
se A
D mo
del
MCAO
rat s
troke
mod
el Tg
F334
-AD
rats
healt
hy ra
ts EA
E MS
mod
el
cogn
itive d
iscor
dant
AD tw
ins
insuli
n res
istan
t pts
at ris
k for
cogn
itive
impa
irmen
t and
deme
ntia
psyc
hosis
patie
nts
schiz
ophr
enia
patie
nts
Natal
izuma
b, MS
) dis
ease
char
acter
isatio
n co
-loca
lisati
on w
ith T
MSX
(in R
RMS)
, with
[18
F]MP
EP an
d [18
F]DO
PA (in
PD)
or w
ith
PIB
in su
bjects
with
insu
lin re
sistan
ce be
ing
at ris
k for
cogn
itive i
mpair
ment
and d
emen
tia
[18F]
FEMP
A
AD
and c
ontro
l pati
ents
disea
se ch
arac
terisa
tion
trace
r qua
nitific
ation
Mi
crog
lia tr
acer
s (TS
PO),
new
trace
rs va
lidat
ed
[18F]
DPA-
714
healt
hy m
ice
QA ra
t mod
el of
NI
AMPA
rat m
odel
of NI
Tg
F344
-AD
rats
local
brain
IL-4
injec
tion r
at mo
del o
f NI
local
brain
LPS
injec
tion r
at mo
del o
f NI
tMCA
O (m
ice) s
troke
mod
el me
sial te
mpor
al lob
e epil
epsy
mou
se m
odel
(KA)
rA
AV-m
ediat
ed a-
SYN
mous
e PD
mode
l 6-
OHDA
mou
se an
d rat
PD m
odel
EAE-
PLP
mous
e MS
mode
l MB
P sp
inal c
ord M
S ra
t mod
el SO
D1 m
ouse
ALS
mod
el AP
P/PS
1-21
mou
se A
D mo
del
Cupr
izone
mou
se M
S mo
del
ortho
topic
gliom
a mod
el Mu
ltifun
ction
al pr
otein-
2 (MF
P2) K
O mo
use
mode
l mo
del o
f por
cine e
ndoth
elium
trace
r biod
istrib
ution
, cha
racte
risati
on an
d qu
antifi
catio
n mo
del c
hara
cteris
ation
dir
ect c
ompa
rison
with
newl
y dev
elope
d TSP
O tra
cers
(e.g.
F-DP
A)
treatm
ent fo
llow-
up (S
KI-II
trea
tmen
t in E
AE-
PLP
mice
, ErP
C3 tr
eatm
ent in
gliom
a, die
tary
inter
venti
on in
stro
ke)
char
acter
isatio
n of a
ffinity
of en
dothe
lial T
SPO
and c
hara
cteris
ation
of its
func
tion i
n the
ho
meos
tasis
of the
bloo
d bra
in ba
rrier
AD an
d MCI
patie
nts
ALS
patie
nts
healt
hy vo
luntee
rs str
oke p
atien
ts, in
cludin
g cer
ebra
l vas
culiti
s
disea
se ch
arac
terisa
tion
trace
r qua
nitific
ation
[18F]
GE-1
80
strok
e mod
el DT
H an
d MOG
-EAE
MS
mode
l AP
P/PS
1-21
mou
se A
D mo
del
LPS
injec
tion m
odel
trace
r vali
datio
n and
quan
tifica
tion
direc
t com
paris
on w
ith P
K111
95 an
d DPA
-714
tre
atmen
t follo
w-up
(FTY
720 (
Fingo
limod
) and
an
ti-VLA
-4 in
MS,
JZL1
84 in
AD)
multip
le sy
stem
atrop
hy
strok
e AD
and M
CI pa
tients
he
althy
contr
ols
direc
t trac
er co
mpar
ison w
ith P
K111
95
disea
se ch
arac
terisa
tion
trace
r qua
ntific
ation
, kine
tic m
odell
ing
Micr
oglia
trac
ers (
TSPO
), ne
wly d
evelo
ped
trace
rs
[18F]
F-DP
A AP
P/PS
1-21
mou
se A
D mo
del
trace
r cha
racte
risati
on an
d dire
ct co
mpar
ison
with
other
TSP
O tra
cers
(DPA
-714
and P
BR28
)
[18F]
12
AMPA
rat m
odel
trace
r cha
racte
risati
on
[18F]
23
AMPA
rat m
odel
trace
r cha
racte
risati
on
[18F]
FE-O
-SSR
1805
75 an
d [18
F]FP
-O-
SSR1
8057
5 tox
ic ra
t NI m
odel
trace
r cha
racte
risati
on
[18F]
FP-N
-SSR
1805
75
toxic
rat N
I mod
el tra
cer c
hara
cteris
ation
[18
F]Flu
oro(
aceta
mide
)-SSR
1805
75
toxic
rat N
I mod
el tra
cer c
hara
cteris
ation
[18
F]DP
A-C5
yne
AMPA
rat N
I mod
el tra
cer c
hara
cteris
ation
, dire
ct co
mpar
ison w
ith
DPA-
714
[18F]
VC70
1 he
althy
rats
LPS
rat a
nd m
ouse
mod
el QA
rat H
D mo
del
EAE
MS m
odel
trace
r cha
racte
risati
on
treatm
ent fo
llow-
up (C
yclos
porin
e A an
d mo
nteluk
ast)
[18F]
CfO-
DPA-
714
AMPA
rat N
I mod
el tra
cer c
hara
cteris
ation
, dire
ct co
mpar
ison w
ith
Trac
ers
type
of a
nim
al m
odel
type
of a
nim
al st
udy
type
of h
uman
pat
holo
gy
type
of h
uman
stud
y DP
A-71
4 Mi
crog
lia tr
acer
s (P2
X7),
newl
y dev
elope
d [11
C]SM
W13
9 ra
t hP2
X7 ov
erex
pres
sion m
odel
rat Q
A les
ion m
odel
trace
r cha
racte
risati
on
[11C]
JNJ5
4173
717
rat h
P2X7
over
expr
essio
n mod
el SO
D1 A
LS m
odel
trace
r cha
racte
risati
on
mode
l cha
racte
risati
on
[11C]
A740
003
expe
rimen
tal st
roke
au
togra
diogr
aphy
Mi
crog
lia tr
acer
s (CG
RP),
newl
y dev
elope
d [11
C]MK
4232
LP
S ra
t mod
el au
torad
iogra
phy
Micr
oglia
trac
ers (
P2Y1
2), n
ewly
deve
lope
d [11
C]P2
Y12-
PET
trace
r ex
perim
ental
stro
ke
autor
adiog
raph
y
Mi
crog
lia tr
acer
s (CS
F1R)
, new
ly de
velo
ped
[11C]
BA1
healt
hy
autor
adiog
raph
y and
in vi
vo P
ET
Tau
trace
rs
[18F]
THK-
5117
Tg
F334
-AD
rats
mode
l and
trac
er ch
arac
terisa
tion
[18F]
T807
Tg
F334
-AD
rats
mode
l cha
racte
risati
on
[18F]
AV14
51
H4 R
ecep
tor s
yste
m tr
acer
s, ne
wly d
evelp
ed
[11C]
JNJ7
7712
0 no
rmal
rats
loc
al ne
uroin
flamm
ation
(LPS
) rat
mode
l ka
inic a
cid m
ouse
mod
el
biodis
tributi
on
autor
adiog
raph
y (ra
t and
mou
se m
odels
) in
vivo P
ET (r
at mo
del)
[11C]
JNJ3
9594
906
norm
al ra
ts au
torad
iogra
phy
CB1R
trac
ers,
esta
blish
ed
[18F]
FMPE
P-d2
AP
P/PS
1-21
mou
se A
D mo
del
mode
l cha
racte
risati
on
treatm
ent fo
llow
up (J
ZL18
4)
PD pa
tients
dis
ease
char
acter
isatio
n
[18F]
MK-9
470
strok
e HD
mou
se m
odel
mode
l cha
racte
risati
on
CB1R
trac
ers,
newl
y dev
elope
d [12
5I]SD
7015
CB
1R K
O mi
ce
trace
r vali
datio
n (in
vivo S
PECT
)
CB
2R tr
acer
s, ne
wly d
evelo
ped
[11C]
NE40
no
rmal
rats
strok
e mi
cro P
ET_M
RI
mode
l cha
racte
risati
on
healt
hy vo
luntee
rs AD
patie
nts
PD pa
tients
dosim
etry,
biodis
tributi
on
kineti
c mod
elling
tes
t-rete
st va
riabil
ity
[11C]
-MA2
CB
2R re
porte
r gen
e rats
tra
cer e
valua
tion (
in viv
o PET
)
[18
F]-M
A3
CB2R
repo
rter g
ene r
ats
trace
r eva
luatio
n (AR
)
[11
C]-A
8363
39
AMPA
rat m
odel
strok
e rat
mode
l LP
S ra
t mod
el
trace
r eva
luatio
n (AR
and i
n vivo
PET
)
[18F]
FC-0
324
norm
al ra
ts bio
distrib
ution
stud
y / m
etabo
lism
Rece
ptor
syst
em tr
acer
s [18
F]FP
EB (m
GluR
5)
6-OH
DA ra
t PD
mode
l QA
rat H
D mo
del
mode
l cha
racte
risati
on an
d eva
luatio
n of
levod
opa t
hera
py (P
D)
mode
l cha
racte
risati
on (H
D)
[18F]
IAM6
067 (
sigma
-1 R
), ne
wly
deve
loped
6-
OHDA
mou
se P
D mo
del
norm
al an
d AMP
A les
ioned
Wist
ar ra
ts tra
cer c
hara
cteris
aton,
quan
tifica
tion (
in viv
o PE
T)
[11C]
GMOM
(NMD
A)
healt
y volu
nteer
s firs
t in hu
man s
tudy,
trace
r kine
tics
[11C]
TMSX
(ade
nosin
e A2A
R)
healt
hy co
ntrols
MS
patie
nts
trace
r qua
ntific
ation
Trac
ers
type
of a
nim
al m
odel
type
of a
nim
al st
udy
type
of h
uman
pat
holo
gy
type
of h
uman
stud
y PD
patie
nts
[123I]
Iomaz
enil (
benz
odiaz
epine
) LP
S mo
use m
odel
mode
l cha
racte
risati
on
[18F]
ASEM
(alph
a7 ni
cotin
ic re
cepto
rs)
TgF3
44-A
D ra
ts mo
del c
hara
cteris
ation
[11
C]Ra
clopr
ide (d
opam
ine D
2)
QA ra
t mod
el tre
atmen
t follo
wup (
Cyclo
spor
ine A
)
MA
O-B
trace
rs, n
ewly
deve
lope
d [18
F]flu
orod
epre
nyl-D
2 he
althy
(men
and m
onke
y) bio
distrib
ution
, auto
radio
grap
hy, in
vivo
PET
(m
odell
ing)
[11C]
AZD2
184
Tg25
76 A
D mi
ce
mode
l cha
racte
risati
on
MMP
trace
rs
[18F]
AS10
1
[18
F]BR
-351
mo
use s
troke
mod
el mo
use g
lioma
mod
el mo
del c
hara
cteris
ation
gli
oblas
toma p
atien
ts MS
patie
nts (R
RMS)
COX-
2 tra
cers
, new
ly de
velo
ped
[11C]
VA42
26
healt
hy ro
dents
LP
S ra
t and
mou
se m
odel
trace
r biod
istrib
ution
(in an
d ex v
ivo)
Dopa
min
e tra
nspo
rter
[18F]
LBT-
999
6-OH
DA ra
t PD
mode
l tre
atmen
t stud
y (pr
otecti
on of
dopa
mine
rgic
neur
ons b
y an a
lpha 7
nico
tinic
rece
ptor
agon
ist)
[18F]
FECT
rA
AV-m
ediat
ed a-
SYN
rat P
D mo
del
MPTP
trea
ted w
t and
TRE
M2 -/
-mice
mo
del c
hara
cteris
ation
[123I]
Ioflup
ane
Healt
hy m
ice, 6
-OHD
A mo
use P
D mo
del
feasib
ility,
optim
isatio
n and
valid
ation
of st
riatal
DA
T me
asur
emen
t , PD
mod
el ch
arac
terisa
tion
Sero
toni
ne tr
ansp
orte
r [11
C]DA
SB
pres
ympto
matic
HD
gene
carri
ers
disea
se ch
arac
terisa
tion (
in co
mpar
ison w
ith
PK11
195)
Pe
rfusio
n tra
cers
99
mTc-D
TPA
expe
rimen
tal st
roke
mod
el mo
del c
hara
cteris
ation
[99
mTc]H
MPAO
LP
S mo
use m
odel
asph
yxia
rat m
odel
expe
rimen
tal st
roke
mod
el
mode
l cha
racte
risati
on
[201T
l]DDC
Tg
F344
-AD
rats
mode
l cha
racte
risati
on
phos
phod
ieste
rase
10A
trace
r [1
8F]JN
J422
5915
2 HD
mou
se m
odel
mode
l cha
racte
risati
on
Gluc
ose m
etab
olism
trac
ers
[18F]
FDG
healt
hy ra
ts he
althy
mice
AP
P/PS
1-21
mou
se A
D mo
del
APPs
we/P
S1dE
9 mou
se A
D mo
del
HD m
ouse
mod
el LP
S mo
use m
odel
set-u
p of p
harm
acok
inetic
para
metric
map
in
vivo a
rt inp
ut fun
ction
deter
mina
tion u
sing a
sm
all be
ta de
tector
in ao
rta
longit
udina
l PET
stud
y, tog
ether
with
DPA
-714
an
d FMP
EP-d
2, PK
1119
5 or M
K-94
70 an
d JN
J422
5915
2 bio
distrib
ution
stud
y with
[99m
Tc]H
MPAO
and
[123I]
Iomaz
enil
aging
AD
and M
C pa
tients
co
mpar
ison o
f diffe
rent
PVC
metho
ds
identi
ficati
on of
best
kineti
c mod
el mu
lti-tra
cer lo
ngitu
dinal
PET
studie
s (DE
D,
PIB,
PK1
1195
, FDG
)
Table
3:
List o
f MR
read
out s
tudies
.
MR re
ad-o
ut
path
olog
y an
imal
mod
els
functi
onal
conn
ectiv
ity hy
persy
nchr
ony
Amylo
id-b d
epos
itions
Tg
2576
and P
DAPP
mice
Ma
gneti
satio
n tra
nsfer
contr
ast
Amylo
id-b d
epos
itions
AP
P/PS
1 mice
MS, n
euro
inflam
mator
y res
pons
e, IL-
13 m
odula
tion
CPZ
mous
e mod
els
FC
hypo
thalam
us-p
ituita
ry-go
nada
l axis
(HPG
-axis
) der
egula
tion
ovar
iectom
ised m
ice (W
T an
d Tg2
576)
functi
onal
netw
ork c
onne
ctivit
y cha
nges
Tg
F344
-AD
rat
T2-w
eighte
d MRI
MS
, neu
roinf
lamma
tory r
espo
nse,
IL-13
mod
ulatio
n CP
Z mo
use m
odels
Mu
lti-ec
ho T
2 MS
, neu
roinf
lamma
tory r
espo
nse
CPZ
mous
e mod
els
Diffu
sion k
urtos
is im
aging
(DKI
) HD
, alte
ratio
n of ti
ssue
micr
ostru
cture
YA
C128
mou
se m
odel
for H
D
MS
, cor
tical
alter
ation
s, wh
ite m
atter
patho
logy
CPZ
mous
e mod
els
Diffu
sion t
enso
r imag
ing (D
TI)
HD, a
ltera
tion o
f tiss
ue m
icros
tructu
re
YAC1
28 m
ouse
mod
el for
HD
MS, c
ortic
al alt
erati
ons,
white
matt
er pa
tholog
y CP
Z mo
use m
odels
1H
-MRS
AL
S SO
D1G9
3A m
odel
N-ac
etyl a
spar
tate,
glutam
ate, m
yo-In
osito
l, cre
atine
, taur
ine, to
tal C
holin
e (ch
oline
and p
hosp
hoch
oline
, glyc
erop
hosp
hoch
oline
), glu
tamine
and G
ABA
Tg25
76 A
D mi
ce
TgF3
44-A
D ra
ts 19
F-MR
I with
rhod
amine
-labe
lled 1
9F na
nopa
rticles
ma
croph
age i
nfiltra
tion
CPZ/
EAE
and E
AE m
ouse
mod
els
Hype
rpola
rised
13C-
MRSI
pr
oinfla
mmato
ry ma
croph
ages
CP
Z mo
use m
odel
(micr
on-si
zed)
iron o
xide n
anop
artic
les, M
RI
neur
ogen
esis
in HD
YA
C128
mou
se m
odel
for H
D
T2 m
aps
brain
infar
ction
MC
AO st
roke
mod
el T1
w-MR
I with
para
magn
etic m
icelle
s tar
getin
g the
infla
med e
ndoth
elium
(VCA
M-1 r
ecep
tors)
Patho
logies
invo
lving
activ
ated e
ndoth
elium
LP
S int
rastr
iatum
mou
se m
odel
Voxe
l-bas
ed m
orph
ometr
y br
ain at
roph
y Tg
F344
-AD
rats
Table
4:
List o
f trea
tmen
t stud
ies in
vitro
.
Targ
et
test
ed d
rugs
or p
athw
ay m
odul
ator
s Pa
rtner
m
icrog
lia ac
tivity
estro
gens
, 17β
-estr
adiol
P2
LPS
P21,
P28
IL-
4, IL-
13
P28
CO
X-2,
PGE2
P6
TSPO
/PK1
1195
P1
0, P1
8a
CL
EC7A
, CHG
B, IF
IH1 a
nd T
LR5
P21
Ca
2+-a
ctiva
ted K
+ ch
anne
l KCa
3.1 m
odula
tors
P28
str
oke
P2, P
6
Stat6
/Jak3
-dep
ende
nt pa
thway
mod
ulator
s P6
α-SY
N as
semb
lies (
mono
meric
, olig
omer
ic or
diffe
rent
fibrill
ar st
rains
P1
3b
Aβ
1-42
P2
1
ATP
P21,
P28
CX
CR3 s
ignall
ing
P21
leu
kotrie
ne LT
C4 an
d LTD
4 and
inhib
itors
of leu
kotrie
ne re
cepto
rs P3
M1
phe
noty
pe sp
ecifi
cally
P2X7
, Mar
co, T
SPO,
CD6
8, MH
CII
WP1
partn
ers
TN
F-α,
IL-1
β, P2
8 M2
phe
noty
pe sp
ecifi
cally
P2Y1
2 W
P1 pa
rtner
s
Arg-
1, Ym
-1 an
d Fizz
-1
P28
Table
5:
List o
f trea
tmen
t stud
ies in
vivo
.
Anim
al m
odels
te
sted
dru
gs o
r pat
hway
mod
ulat
ors
Partn
er
Patie
nt
popu
latio
n dr
ug
Partn
er
norm
al ag
ing
WT
rats
leuko
triene
rece
ptor in
hibito
r (Mo
nteluk
ast)
P3
W
T mi
ce
hypo
thalam
us-p
ituita
ry-go
nada
l axis
(HPG
-axis
) der
egula
tion (
ovar
iectom
y) P2
, P7
estro
gens
, 17β
-estr
adiol
P2
LP
S P2
IL-
4, IL-
13
P2
NF
-kB-L
uc m
ouse
repo
rter
estro
gens
, 17β
-estr
adiol
P2
LP
S P2
IL-
4, IL-
13
P2
Al
zheim
er d
iseas
e AP
Pswe
/PS1
dE9 m
ice
piogli
tazon
e (PP
AR-g
amma
agon
ist)
P1
MCI
Etan
erce
pt P1
0a,
P17
JZ
L184
(MAG
L inh
ibitor
) P1
6
PDAP
P mi
ce
3D6 (
anti-A
b imm
unoth
erap
y) P7
APP/
PS1-
21
JZL1
84 (M
AGL i
nhibi
tor)
P16
Tg
2576
mice
hy
potha
lamus
-pitu
itary-
gona
dal a
xis (H
PG-a
xis) d
ereg
ulatio
n (ov
ariec
tomy)
P2, P
7
TgF3
44-A
D ra
ts pe
riphe
ral in
flamm
ation
(urin
ary t
ract
infec
tion)
P1
0b
Ag
ing in
AD
mode
ls (A
PPsw
e/PS1
dE9 a
nd
Tg25
76 m
ouse
mod
el)
neur
ogen
esis
P3
, P7,
P21
Park
inso
n di
seas
e α-
synu
clein
AAV
rat m
odel
FK50
6 (Ta
crolim
us, im
muno
philin
ligan
d)
P13b
PDGF
b aSY
N tra
nsge
nic m
ice (L
BD m
odel)
leu
kotrie
ne re
cepto
r inhib
itor (
Monte
lukas
t) P3
6-OH
DA ra
t mod
el PH
A 54
3613
, an α
7nAC
hRs a
gonis
t P4
MS
EAE-
PLP
mice
SK
I-II tr
eatm
ent (
sphin
gosin
e kina
se in
hibito
r) P1
5 RR
MS
Fingo
limod
P1
6 DT
H an
d MOG
-EAE
MS
mode
l FT
Y720
(Fing
olimo
d, a s
phing
osine
-1-p
hosp
hate
rece
ptor m
odula
tor)
P16
SPMS
na
talizu
mab
P16
an
ti-VLA
-4 (v
ery l
ate an
tigen
-4 (V
LA-4
) integ
rin an
tibod
y)
P16
MS
IgG A
b the
rapy
P1
4
BG-1
2 (Te
cfide
ra),
a Nrf2
-sign
al pa
thway
(Nuc
lear F
actor
(Eryt
hroid
-Der
ived 2
)-Rela
ted F
actor
2 ac
tivato
r) P1
6 AI
ence
phali
tis
cortic
oster
oid an
d Ig
thera
py
P14
cupr
izone
mou
se m
odel
of MS
loc
al IL-
13 ex
pres
sion (
LVV
or M
SCs)
P7, P
6
On
costa
tin M
, a m
embe
r of th
e IL-
6 cyto
kine f
amily
P1
3b
Fo
cal d
emye
linati
on (e
thidiu
m br
omide
) in th
e ra
t cer
ebell
um
syste
mic i
njecti
on of
MSC
s der
ived f
rom
youn
g or a
ged d
onor
anim
als
P3
Co
ntribu
tion o
f per
icytes
to di
ffere
ntiati
on of
OPC
s P3
Foca
l dem
yelin
ation
(lyso
lecith
in) in
the
mous
e spin
al co
rd
Contr
ibutio
n of p
ericy
tes to
diffe
renti
ation
of O
PCs
P3
Othe
r mod
els
ortho
topic
gliom
a mod
el Er
PC3 (
Erufo
sine,
a pro
apop
totic
alkylp
hosp
hoch
oline
) P8
tMCA
O mo
use s
troke
mod
e FT
Y720
(Fing
olimo
d, a s
phing
osine
-1-p
hosp
hate
rece
ptor m
odula
tor)
P6
Forta
syn,
dietar
y sup
pleme
nt P1
QA ra
t mod
el PH
A 54
3613
, an α
7nAC
hRs a
gonis
t Mo
nteluk
ast
Cyclo
spor
ine A
P4
P11
P11
3.1.
2 IP
dev
elop
ed
Table
6:
List o
f IP de
velop
ed.
Ty
pe o
f IP
deve
lopm
ent
Activ
ity ca
tego
ry
Title
of I
P de
velo
pmen
t Sh
ort d
escr
iptio
n of
IP
deve
lopm
ent
Owne
r of I
P de
velo
ped
& ot
her
bene
ficiar
y(s)
in
volve
d
Type
of e
nd-u
sers
of
the d
evelo
ped
IP
Shor
t des
crip
tion
of
end-
user
s Mo
de o
f di
ssem
inat
ion/
expl
oita
tion
1 Sc
ientifi
c Ne
w im
aging
hard
- or s
oftwa
re
Supe
rvise
d clus
ter
analy
sis al
gorith
m So
ftwar
e meth
od to
defin
e re
feren
ce tis
sue o
bjecti
vely;
thi
s is a
n imp
rove
d mo
difica
tion o
f a pr
eviou
sly
publi
shed
meth
od
P9(3
1), P
18, P
10
Imag
ing an
d pos
sibly
clinic
al sc
ientis
ts Ce
ntres
that
are
inter
ested
in im
aging
ne
uroin
flamm
ation
Peer
-revie
wed p
ublic
ation
and
distrib
ution
of so
ftwar
e pac
kage
to
inter
ested
centr
es, fi
rst w
ithin
INMi
ND, la
ter al
so ou
tside
2 Sc
ientifi
c Ne
w sp
ecific
prob
es, c
ompo
unds
or
CNS
activ
e mole
cules
MR
I age
nt for
the
visua
lisati
on of
infla
med
endo
theliu
m
Mice
lles l
oade
d with
a pa
rama
gneti
c Gd-
comp
lex an
d ex
posin
g a pe
ptide
targ
eting
VC
AM-1
rece
ptors
P5
Imag
ing sc
ientis
ts Sc
ientis
ts int
eres
ted in
the
visu
alisa
tion o
f inf
lamma
tion (
includ
ing
neur
oinfla
mmati
on)
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
3 Sc
ientifi
c Ne
w sp
ecific
prob
es, c
ompo
unds
or
CNS
activ
e mole
cules
NI
RF ag
ent to
be
incor
pora
ted in
lipop
hilic
nano
partic
les
Cyan
ine co
njuga
ted w
ith a
phos
pholi
pid
P5
Imag
ing sc
ientis
ts Sc
ientis
ts int
eres
ted in
the
deve
lopme
nt of
nano
- mi
cropa
rticles
for N
IRF
imag
ing (in
cludin
g ap
plica
tions
in
neur
oscie
nce)
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
4 Sc
ientifi
c Ne
w sp
ecific
prob
es, c
ompo
unds
or
CNS
activ
e mole
cules
MR
I/NIR
F ag
ents
for
cellu
lar im
aging
Gl
ucan
partic
les lo
aded
with
lip
ophil
ic MR
I/NIR
F im
aging
P5
Im
aging
scien
tists
Scien
tists
inter
ested
in
the de
velop
ment
of im
aging
proc
edur
es fo
r tra
cking
cells
in vi
vo
(inclu
ding r
ecru
itmen
t of
immu
ne ce
lls in
ne
uroin
flame
d are
a)
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
5 Te
chno
logica
l Ne
w an
imal
mode
l α-
synu
clein-
base
d ro
dent
mode
l for
Parki
nson
's dis
ease
Robu
st an
d rap
id α-
synu
clein-
base
d rat/
mous
e mod
el for
Pa
rkins
on's
disea
se
P13a
Ba
sic sc
ientis
ts,
biotec
h/pha
rma
indus
try
Neur
oscie
nce
Confe
renc
e talk
, pos
ter, d
irect
e-ma
iling
6 Te
chno
logica
l Ne
w vir
al ve
ctor t
echn
ology
St
ate-o
f-the
-art
viral
vecto
r tec
hnolo
gy
Lenti
viral-
and a
deno
-as
socia
ted vi
ral v
ector
-bas
ed
techn
ology
P13a
Ba
sic sc
ientis
ts,
biotec
h/pha
rma
indus
try
Basic
rese
arch
, dru
g dis
cove
ry &
deve
lopme
nt pr
oces
s
Confe
renc
e talk
, pos
ter, d
irect
e-ma
iling
7 Sc
ientifi
c Ne
w sp
ecific
prob
es, c
ompo
unds
or
CNS
activ
e mole
cules
Na
nosiz
ed M
RI ag
ents
Dend
rimer
some
s loa
ded w
ith
MRI a
gents
P5
Ba
sic sc
ientis
ts,
biotec
h/pha
rma
indus
try, Im
aging
sc
ientis
ts
Scien
tists
inter
ested
in
the de
sign o
f na
noca
rrier
s for
de
liver
ing dr
ug/im
aging
ag
ents
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
8 Sc
ientifi
c Ne
w sp
ecific
prob
es, c
ompo
unds
or
CNS
activ
e mole
cules
PE
T ra
diolig
ands
for
visua
lisati
on of
ne
uroin
flamm
ation
Impr
oved
radio
trace
rs for
im
aging
TSP
O: [1
8F]D
PA-7
14,
[18F]
CfO-
DPA-
714 a
nd
analo
gs, [1
8F]D
PA-C
5yne
P8
Imag
ing sc
ientis
ts Sc
ientis
ts int
eres
ted in
the
visu
alisa
tion o
f inf
lamma
tion (
includ
ing
neur
oinfla
mmati
on) a
nd
the us
e of a
ltern
ative
s im
aging
prob
es
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
9 Sc
ientifi
c Ne
w sp
ecific
prob
es, c
ompo
unds
or
CNS
activ
e mole
cules
MR
I pro
be pr
ecur
sors
Bifun
ction
al ch
elatin
g age
nts
for th
e pre
para
tion o
f P2
4 Ba
sic sc
ientis
ts,
biotec
h/pha
rma
Scien
tists
inter
ested
in
the pr
epar
ation
of
Poste
r, an
d pee
r-rev
iewed
pu
blica
tions
Ty
pe o
f IP
deve
lopm
ent
Activ
ity ca
tego
ry
Title
of I
P de
velo
pmen
t Sh
ort d
escr
iptio
n of
IP
deve
lopm
ent
Owne
r of I
P de
velo
ped
& ot
her
bene
ficiar
y(s)
in
volve
d
Type
of e
nd-u
sers
of
the d
evelo
ped
IP
Shor
t des
crip
tion
of
end-
user
s Mo
de o
f di
ssem
inat
ion/
expl
oita
tion
conju
gated
prob
es
indus
try, Im
aging
sc
ientis
ts im
aging
prob
es
10
Scien
tific
New
imag
ing ha
rd- o
r soft
ware
4D
grad
ient v
ector
flow
Softw
are m
ethod
to de
fine
kineti
c reg
ion of
inter
est
P4
Imag
ing an
d clin
ical
scien
tists
Scien
tists
need
ing to
de
fine a
conn
ex re
gion o
f int
eres
t bas
ed on
ra
diotra
cer k
inetic
s
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
11
Scien
tific
New
spec
ific pr
obes
, com
poun
ds
or C
NS ac
tive m
olecu
les
PET
trace
r for
imag
ing
of the
P2X
7 rec
eptor
Br
ain pe
rmea
ble P
2X7 t
race
r lab
elled
with
carb
on-1
1 P1
3a
Imag
ing sc
ientis
ts,
clinic
al sc
ientis
ts Sc
ientis
ts int
eres
ted in
the
visu
alisa
tion o
f inf
lamma
tion (
includ
ing
neur
oinfla
mmati
on)
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
12
Scien
tific
New
spec
ific pr
obes
, com
poun
ds
or C
NS ac
tive m
olecu
les
PET
trace
r for
imag
ing
of the
CB2
rece
ptor
Brain
perm
eable
CB2
rece
ptor
agon
ists l
abell
ed w
ith ca
rbon
-11
P13a
Im
aging
scien
tists,
po
ssibl
y clin
ical
scien
tists
Scien
tists
inter
ested
in
the vi
suali
satio
n of
inflam
matio
n (inc
luding
ne
uroin
flamm
ation
)
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
13
Tech
nolog
ical
New
anim
al mo
del
Rat m
odel
of loc
al ne
uroin
flamm
ation
Ro
bust
rat m
odel
of ne
uroin
flamm
ation
that
allow
s ev
aluati
on of
PET
trac
ers
targe
ting n
euro
inflam
matio
n
P13a
Ba
sic sc
ientis
ts,
biotec
h/pha
rma
indus
try
Neur
oscie
nce
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
14
Tech
nolog
ical
prod
uctio
n of 1
8F-D
PA-7
14 fo
r cli
nical
appli
catio
n GM
P va
lidate
d pr
oduc
tion o
f 18F
-DPA
-71
4
Valid
ated p
rodu
ction
of 18
F-DP
A-71
4 for
clini
cal
appli
catio
n, inc
luding
IMPD
so
that c
linica
l rese
arch
ers c
an
quan
tify T
SPO
expr
essio
n in
clinic
al stu
dies
P13a
Cc
linica
l scie
ntists
, ph
arma
ceuti
cal
comp
anies
that
have
int
eres
t to qu
antify
TS
PO ex
pres
sion i
n a
clinic
al stu
dy
Neur
oscie
nce
IMPD
, loca
l diss
imina
tion
15
Tech
nolog
ical
New
anim
al mo
del
Rat m
odel
with
local
hP2X
7 exp
rees
ion
Robu
st ra
t mod
el of
local
hP2X
7 exp
ress
ion fo
r ev
aluati
on an
d com
paris
on of
P2
X7 tr
acer
s
P13a
Ba
sic sc
ientis
ts,
biotec
h/pha
rma
indus
try
Neur
oscie
nce
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
16
Tech
nolog
ical
New
metho
d Iso
lation
of hu
man
micro
glia f
rom
epile
psy
patie
nts
Ion ch
anne
l exp
ress
ion,
phar
maco
logy a
nd fu
nctio
n in
naïve
vs. M
1/M2 p
olaris
ed
micro
glia
P28
Basic
scien
tists,
ph
arma
indu
stry
Drug
disc
over
y Po
ster,
Confe
renc
e talk
, and
peer
-re
viewe
d pub
licati
ons
17
Scien
tific
New
spec
ific pr
obes
, com
poun
ds
or C
NS ac
tive m
olecu
les
Matrix
-meta
llo
prote
inase
PET
imag
ing
agen
t in st
roke
and
gliom
a
hydr
oxam
ate-b
ased
MMP
inh
ibitor
[18F]
BR-3
51
P1
Imag
ing an
d pos
sibly
clinic
al sc
ientis
ts Ce
ntres
that
are
inter
ested
in im
aging
ne
uroin
flamm
ation
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
18
Tech
nolog
ical
New
metho
d Ce
ll lab
elling
tech
nique
Hy
po-o
smoti
c sho
ck m
ethod
for
labe
lling c
ells i
n vitro
with
hy
drop
hilic
imag
ing pr
obes
P5
Imag
ing an
d pos
sibly
clinic
al sc
ientis
ts Sc
ientis
ts int
eres
ted in
the
deve
lopme
nt of
imag
ing pr
oced
ures
for
track
ing ce
lls in
vivo
(in
cludin
g migr
ation
of
stem
cells
in
neur
oinfla
med a
rea)
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
19
Scien
tific
New
spec
ific pr
obes
, com
poun
ds
or C
NS ac
tive m
olecu
les
Nano
sized
19F
MRI
agen
ts Flu
orina
ted na
nopa
rticles
for
imag
ing in
flamm
ation
P5
Im
aging
scien
tists
Scien
tists
inter
ested
in
the de
velop
ment
of im
aging
proc
edur
es fo
r tra
cking
cells
in vi
vo
Poste
r, Co
nfere
nce t
alk
Ty
pe o
f IP
deve
lopm
ent
Activ
ity ca
tego
ry
Title
of I
P de
velo
pmen
t Sh
ort d
escr
iptio
n of
IP
deve
lopm
ent
Owne
r of I
P de
velo
ped
& ot
her
bene
ficiar
y(s)
in
volve
d
Type
of e
nd-u
sers
of
the d
evelo
ped
IP
Shor
t des
crip
tion
of
end-
user
s Mo
de o
f di
ssem
inat
ion/
expl
oita
tion
(inclu
ding m
igrati
on of
im
mune
syste
m ce
lls in
ne
uroin
flame
d are
a)
20
Tech
nolog
ical
New
imag
ing pr
otoco
l Tw
o-ph
oton I
magin
g Me
thod f
or fu
nctio
nal li
ve ce
ll im
aging
P2
1 Ba
sic sc
ientis
t Sc
ientis
t inter
ested
in th
e de
velop
ment
of im
aging
of
in-viv
o micr
oglia
fun
ction
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
21
Scien
tific
New
spec
ific pr
obes
, com
poun
ds
or C
NS ac
tive m
olecu
les
Spec
ific ge
nes
asso
ciated
with
AD
Gene
expr
essio
n ana
lysis
and
valid
ation
P2
1 Ba
sic sc
ientis
ts,
biotec
h/pha
rma
indus
try
Scien
tist in
teres
ted in
sta
tistic
al an
alysis
of
gene
expr
essio
n pro
file
Poste
r, Co
nfere
nce t
alk, a
nd pe
er-
revie
wed p
ublic
ation
s
3.2
Sect
ion
D –
Tra
inin
g &
Edu
catio
n 3.
2.1
Trai
ning
Ta
ble 7:
Lis
t of tr
aining
cour
ses.
Perio
d Pa
rtner
TS
Co
urse
lead
er
Scien
tific
Advis
or(s
) Ti
tle
Date
s Nu
mbe
r of
parti
cipan
ts
Num
ber o
f IN
MiND
pa
rticip
ants
Num
ber
of
stud
ents
Coun
try o
f orig
in
1 P1
TS
1 AH
. Jac
obs
M. S
chäfe
rs,
S. H
erma
nn
Mous
e ima
ging a
cade
my
5/11/2
012-
9/11/2
012
31
2 0
Germ
any,
Switz
erlan
d, UK
, Irela
nd, S
pain,
De
nmar
k, Sw
eden
1
P2
TS2
A. V
illa
A.Ma
ggi
Desig
n and
gene
ratio
n of r
epor
ter sy
stems
13
/11/20
12-
15/11
/2012
6
4 1
Italy
and F
ranc
e
1 P6
TS
6 A.
Plan
as
C. Ju
sticia
An
imal
mode
ls of
neur
oinfla
mmati
on
17/10
/2012
-19
/10/21
2 6
6 4
Belgi
um, U
K, G
erma
ny
1 P1
4 TS
10
C. S
vare
r GM
. Knu
dsen
Ba
sic ki
netic
mod
elling
in M
I 23
/04/20
12-
27/04
/2012
10
3
10
Denm
ark
Tota
l Per
iod
I: 4 T
rain
ing
cour
ses
53
15
15
2
P1
TS1
AH. J
acob
s M.
Sch
äfers,
S.
Her
mann
Mo
use i
magin
g aca
demy
11
/11/20
13-
15/11
/2013
31
2
31
Austr
ia, C
hina,
Denm
ark,
Germ
any,
India,
the
Nethe
rland
s, Sl
oven
ia, S
pain,
Swi
tzerla
nd, U
SA
2 P3
TS
3 B.
Klei
n L.
Aign
er
Analy
sis of
neur
al ste
m/pr
ogen
itor c
ell pr
olifer
ation
an
d fate
24
/06/20
13-
27/06
/213
8 4
0 Au
stria,
Belg
ium, G
erma
ny an
d UK
2 P9
TS
4 AD
. Wind
horst
G.
Bor
mans
, F.
Doll
é, C.
Hall
din,
J. Ve
rcouil
lie
PET
and S
PECT
radio
-pha
rmac
eutic
als pr
epar
ation
: de
sign,
radio
labell
ing st
rateg
y, ra
diosy
nthes
is an
d dr
ug de
velop
ment
Cour
se A
: Reg
ulator
y Top
ics
28/10
/2013
-31
/10/20
13
6 5
0 Be
lgium
, the N
ether
lands
, and
Swe
den
2 P9
TS
4 AD
. Wind
horst
G.
Bor
mans
, F.
Doll
é, C.
Hall
din,
J. Ve
rcouil
lie
PET
and S
PECT
radio
-pha
rmac
eutic
als pr
epar
ation
: de
sign,
radio
labell
ing st
rateg
y, ra
diosy
nthes
is an
d dr
ug de
velop
ment
Cour
se B
: Rad
ioche
mistr
y and
tra
cer d
evelo
pmen
t
28/10
/2013
-31
/10/20
13
7 6
1 Be
lgium
, Den
mark,
Fra
nce,
the N
ether
lands
, and
Sw
eden
2 P8
TS
8 R.
Bois
gard
F.
Doll
é Sm
all an
imal
PET
imag
ing
04/02
/2014
-07
/02/20
14
9 3
4 Fr
ance
and U
K
2 P9
TS
9 R.
Boell
aard
A.
Lamm
ertsm
a PE
T me
thodo
logy a
nd cl
inica
l imple
menta
tion
25/11
/2013
-27
/11/20
13
8 5
1 Fr
ance
, Italy
, the N
ether
lands
and S
wede
n
2 P1
4 TS
10
C. S
vare
r GM
. Knu
dsen
Ba
sic ki
netic
mod
elling
in M
olecu
lar Im
aging
18
/03/20
13-
22/03
/2013
15
4
4 Be
lgium
, Den
mark,
Hun
gary
and S
witze
rland
2 P1
8 TS
11
F. R
onca
roli
F. R
onca
roli
Adva
nces
in N
euro
patho
logy
and
Neur
obiol
ogy
– ne
uroin
flamm
ation
03
/07/20
13-
05/07
/2013
51
2
2 UK
, Belg
ium an
d the
Neth
erlan
ds
Tota
l Per
iod
II: 8
Train
ing
cour
ses
135
31
43
3
P1
TS1
AH. J
acob
s M.
Sch
äfers,
S.
Her
mann
Mo
use i
magin
g aca
demy
03
/10/20
14-
07/10
/2014
31
2
27
Austr
ia, B
elgium
, Ger
many
, Hun
gary,
Italy,
Sw
itzer
land,
Taiw
an, T
he N
ether
lands
, the U
SA
3 P3
TS
3 B.
Klei
n L.
Aign
er
Analy
sis of
neur
al ste
m/pr
ogen
itor c
ell pr
olifer
ation
an
d fate
23
/06/20
14-
26/06
/2014
6
0 6
Austr
ia an
d Ger
many
3 P7
TS
7 M.
Ver
hoye
A.
Van
der
Linde
n Sm
all an
imal
MR Im
aging
of th
e Cen
tral N
ervo
us
Syste
m 10
/06/20
14-
13/06
/2014
7
6 5
Belgi
um, It
aly an
d the
Neth
erlan
ds
3 P9
TS
4 AD
. Wind
horst
G.
Bor
mans
, PE
T an
d SPE
CT ra
dio-p
harm
aceu
ticals
prep
arati
on:
01/12
/2014
-5
4 2
Belgi
um, U
K, S
wede
n and
Finl
and
Perio
d Pa
rtner
TS
Co
urse
lead
er
Scien
tific
Advis
or(s
) Ti
tle
Date
s Nu
mbe
r of
parti
cipan
ts
Num
ber o
f IN
MiND
pa
rticip
ants
Num
ber
of
stud
ents
Coun
try o
f orig
in
F. D
ollé,
C. H
alldin
, J.
Verco
uillie
desig
n, ra
diolab
elling
stra
tegy,
radio
synth
esis
and
drug
deve
lopme
nt
cour
se A
: Reg
ulator
y top
ics
04/12
/2014
3 P9
TS
4 AD
. Wind
horst
G.
Bor
mans
, F.
Doll
é, C.
Hall
din,
J. Ve
rcouil
lie
PET
and S
PECT
radio
-pha
rmac
eutic
als pr
epar
ation
: de
sign,
radio
labell
ing st
rateg
y, ra
diosy
nthes
is an
d dr
ug de
velop
ment
co
urse
B : R
adioc
hemi
stry a
nd tr
acer
deve
lopme
nt
01/12
/2014
-04
/12/20
14
7 6
4 Fr
ance
, Belg
ium, F
inlan
d, an
d Sau
di Ar
abia
3 P9
TS
9 A.
Lamm
ertsm
a R.
Boe
llaar
d PE
T tra
cer p
harm
acok
inetic
s and
data
analy
sis
proc
edur
es
17/11
/2014
-19
/11/20
14
14
3 10
Be
lgium
, Can
ada,
Denm
ark,
UK, F
inlan
d, an
d The
Ne
therla
nds
3 P1
4 TS
10
C. S
vare
r GM
. Knu
dsen
Ba
sic ki
netic
mod
elling
in M
I 10
/03/20
14-
14/03
/2014
16
1
14
Denm
ark,
Belgi
um, P
oland
, and
Swe
den
Tota
l Per
iod
III: 7
train
ing
cour
ses
86
22
68
4
P14
TS10
D.
Giva
rd
GM. K
nuds
en
Basic
kine
tic m
odell
ing in
MI
02/03
/15-
06/03
/15
15
4 5
Austr
ia, B
elgium
, Den
mark,
Finl
and
4 P7
TS
7 M.
Ver
hoye
M.
Ver
hoye
Sm
all A
nimal
MR Im
aging
of th
e Cen
tral N
ervo
us
Syste
m 04
/05/15
-08
/05/15
7
3 3
Fran
ce, It
aly, th
e Neth
erlan
ds
4 P1
8 TS
11
F. R
onca
roli
F. R
onca
roli
BNS
Summ
er S
choo
l - Ce
rebr
ovas
cular
Dise
ases
: Ge
netic
s and
Path
ophy
siolog
y 01
/07/15
-03
/07/15
33
1
1 UK
, Spa
in
4 P6
TS
6 A.
Plan
as
C. Ju
sticia
An
imal
mode
ls of
neur
oinfla
mmati
on
01/10
/15-
02/10
/15
8 3
6 Be
lgium
, Fra
nce,
Polan
d
4 P9
TS
4 AD
. Wind
horst
G.
Bor
mans
, F.
Doll
é, C.
Hall
din,
J. Ve
rcouil
lie
PET
and S
PECT
radio
-pha
rmac
eutic
als pr
epar
ation
: de
sign,
radio
labell
ing st
rateg
y, ra
diosy
nthes
is an
d dr
ug de
velop
ment
co
urse
B : R
adioc
hemi
stry a
nd tr
acer
deve
lopme
nt
02/11
/15-
05/11
/15
5 4
3 Be
lgium
, Finl
and,
Norw
ay, S
wede
n
4 P1
TS
1 AH
. Jac
obs
M. S
chäfe
rs,
S. H
erma
nn
Mous
e ima
ging a
cade
my
09/11
/15-
13/11
/15
27
3 3
Fran
ce, It
aly, th
e Neth
erlan
ds, U
SA, S
wede
n, Ge
rman
y, UK
4
P9
TS9
A. La
mmer
tsma
R. B
oella
ard
PET
trace
r pha
rmac
okine
tics a
nd da
ta an
alysis
pr
oced
ures
16
/11/15
-18
/11/15
11
5
5 Fin
land,
Fran
ce, G
erma
ny, th
e Neth
erlan
ds,
Spain
, Swe
den,
UK
4 P2
TS
2 A.
Villa
A.
Mag
gi Tr
aining
for m
entor
s – Im
aging
of ne
uroin
flamm
ation
in
neur
odeg
ener
ative
dise
ases
: a di
scus
sion o
n wha
t we
lear
ned i
n the
se pa
st 4 y
ears
03/12
/15-
04/12
/15
36
36
2 Ita
ly, S
wede
n, Be
lgium
, Aus
tria, H
unga
ry, F
ranc
e, UK
Tota
l Per
iod
IV: 8
train
ing
cour
ses
142
59
28
5
P14
TS10
D.
Giva
rd
GM. K
nuds
en
Basic
kine
tic m
odell
ing in
MI
29/02
/2016
-04
/03/20
16
13
0 7
Germ
any,
Denm
ark,
Fran
ce
5 P1
TS
1 AH
. Jac
obs
M. S
chäfe
rs,
S. H
erma
nn
Mous
e ima
ging a
cade
my
14/11
/2016
-18
/11/20
16
19
0 6
Belgi
um, G
erma
ny, A
ustria
5 P9
TS
9 A.
Lamm
ertsm
a R.
Boe
llaar
d PE
T tra
cer p
harm
acok
inetic
s and
data
analy
sis
proc
edur
es
21/11
/2016
-23
/11/20
16
9 4
7 Ita
ly, U
K, G
erma
ny, B
elgium
, Spa
in, T
he
Nethe
rland
s 5
P14
TS10
D.
Giva
rd
GM. K
nuds
en
Basic
kine
tic m
odell
ing in
MI
27/02
/2017
-03
/03/20
17
16
3 15
Fr
ance
, Italy
, Aus
tria, Is
rael,
UK,
Be
lgium
,Den
mark
Tota
l Per
iod
V: 4
train
ing
cour
ses
57
7 35
Tota
l: 31
train
ing
cour
ses
473
134
189
16 E
urop
ean C
ountr
ies (A
ustria
, Belg
ium,
Denm
ark,
Finlan
d, Fr
ance
, Ger
many
, Hun
gary,
Ire
land,
Italy,
Neth
erlan
ds, P
oland
Swi
tzerla
nd,
Slov
enia,
Spa
in, S
wede
n, UK
) and
Chin
a, Ind
ia,
USA
, Taiw
an, S
audi
Arab
ia, C
anad
a, Isr
ael
3.2.
2 Th
eses
Ta
ble 8:
Lis
t of th
eses
.
Da
te Ty
pe
Plac
e Ti
tle
Type
of
audi
ence
Co
untri
es
addr
esse
d Si
ze o
f au
dien
ce
Partn
er re
sp./
invo
lv.
Male/
Fem
ale
Rese
arch
er
Seni
or/st
uden
t
1 15
.11.20
12
Thes
is de
fense
(PhD
in
Biom
edica
l Sc
ience
s)
Facu
lty of
Ph
arma
ceuti
cal,
Biom
edica
l and
Ve
terina
ry Sc
ience
s, Un
iversi
ty of
Antw
erp
(Antw
erp,
Belgi
um)
Title:
Unr
aveli
ng th
e fate
of gr
afted
and
endo
geno
us st
em ce
lls in
mou
se m
odels
of
multip
le sc
leros
is.
Defen
se by
Pra
et J
Supe
rviso
rs: V
an de
r Lind
en A
, Po
nsae
rts P
Rese
arch
Na
tiona
l, Be
lgium
P07/U
A Ma
le St
uden
t
2 12
.12.20
12
Thes
is de
fense
(PhD
) Fa
culty
of M
edica
l an
d Hum
an S
cienc
es,
Unive
rsity
of Ma
nche
ster
(Man
ches
ter, U
K)
Title:
Tra
nsloc
ator p
rotei
n exp
ress
ion an
d mi
crogli
al ac
tivati
on in
gliom
as.
Defen
se by
Su Z
Su
pervi
sors:
Her
holz
K, G
erha
rd A
, Hinz
R,
Jack
son A
Rese
arch
Na
tiona
l, UK
P1
0a/U
niMan
Ma
le St
uden
t
3 31
.05.20
13
Thes
is de
fense
(PhD
in
Medic
ine, M
edici
nal
Radio
chem
istry)
Depa
rtmen
t of C
linica
l Ne
uros
cienc
e -
Karo
linsk
a Ins
titutet
(S
tockh
olm, S
wede
n)
Title:
Dev
elopm
ent o
f Nov
el Flu
orin-
18
Labe
led P
ET R
adiol
igand
s for
Mo
noam
ine O
xidas
e B (M
AO-B
). De
fense
by N
ag S
Su
pervi
sors:
Hall
din C
Rese
arch
Na
tiona
l, Sw
eden
P12a
/KI
Male
Stud
ent
4 05
.09.20
13
Thes
is de
fense
(PhD
in
Medic
ine)
Depa
rtmen
t of
Neur
obiol
ogy,
Care
Sc
ience
s and
Soc
iety
Alzh
eimer
Ne
urob
iolog
y Cen
ter -
Karo
linsk
a Ins
titutet
(S
tockh
olm, S
wede
n)
Title:
Stim
ulatin
g Neu
ropr
otecti
ve an
d Re
gene
rativ
e Mec
hanis
ms in
Alzh
eimer
Di
seas
e. De
fense
by Li
lja A
M Su
pervi
sors:
Nor
dber
g A, M
arutl
e A an
d Ög
ren S
O
Rese
arch
Na
tiona
l, Sw
eden
10
0 P1
2b/K
I Fe
male
Stud
ent
5 09
.09.20
13
Thes
is de
fense
(PhD
in
Biom
edica
l Sc
ience
s)
Facu
lty of
Ph
arma
ceuti
cal,
Biom
edica
l and
Ve
terina
ry Sc
ience
s, Un
iversi
ty of
Antw
erp
(Antw
erp,
Belgi
um)
Title:
Fun
ction
al co
nnec
tivity
analy
sis in
sm
all an
imals
using
resti
ng st
ate fM
RI:
Anes
thesia
indu
ced e
ffect
on in
ter-
hemi
sphe
ric fu
nctio
nal c
onne
ctivit
y. De
fense
by Jo
ncke
rs E
Supe
rviso
rs: V
an de
r Lind
en A
, Ver
hoye
M
Rese
arch
Na
tiona
l, Be
lgium
P07/U
A Fe
male
Stud
ent
6 05
.06.20
14
Thes
is de
fense
(PhD
in
Medic
ine)
Depa
rtmen
t of
Neur
obiol
ogy,
Care
Sc
ience
s and
Soc
iety
Alzh
eimer
Ne
urob
iolog
y Cen
ter -
Karo
linsk
a Ins
titutet
(S
tockh
olm, S
wede
n)
Title:
Reg
ener
ating
the b
rain:
stem
cell
differ
entia
tion a
nd ch
oline
rgic
dysfu
nctio
n in
Anzh
eimer
's Di
seas
e. De
fense
by W
icklun
d- M
almste
n L
Supe
rviso
rs: M
arutl
e A, N
ordb
erg A
, Da
rreh-
Shor
i T an
d Li J
Y
Rese
arch
Na
tiona
l, Sw
eden
10
0 P1
2b/K
I Fe
male
Stud
ent
7 11
.07.20
14
Thes
is de
fense
(PhD
Ne
uros
cienc
es)
Unive
rsity
of Ba
rcelon
a (Ba
rcelon
a, Sp
ain)
Title:
Impli
cació
de la
infla
mació
i la
resp
uesta
inmu
nitàr
ia en
la le
sió in
duïda
pe
r la is
quèm
ia ce
rebr
al.
Defen
se by
Pér
ez de
Puig
I Su
pervi
sor:
Plan
as A
M
Rese
arch
Na
tiona
l, Sp
ain
P0
6/IDI
BAPS
Fe
male
Stud
ent
8 01
.10.20
14
Thes
is de
fense
(PhD
Un
iversi
ty Pa
ris-S
ud,
Title:
PET
mole
cular
imag
ing of
Re
sear
ch
Natio
nal,
P0
8/CEA
Ma
le St
uden
t
Da
te Ty
pe
Plac
e Ti
tle
Type
of
audi
ence
Co
untri
es
addr
esse
d Si
ze o
f au
dien
ce
Partn
er re
sp./
invo
lv.
Male/
Fem
ale
Rese
arch
er
Seni
or/st
uden
t
in Mo
lecula
r Ima
ging)
Un
iversi
té Pa
ris-
Sacla
y (Sa
clay,
Fran
ce)
perip
hera
l and
centr
al inf
lamma
tory
proc
esse
s tar
getin
g the
TSP
O 18
kDa.
Defen
se by
Ber
nard
s N
Supe
rviso
r: Bo
isgar
d R
Fran
ce
9 30
.01.20
15
Thes
is de
fense
(PhD
in
Clini
cal P
hysio
logy
and N
uclea
r Me
dicine
)
Turku
PET
Cen
tre,
Facu
lty of
Med
icine
, Un
iversi
ty of
Turku
(T
urku
, Finl
and)
New
[18F]
trace
rs for
Alzh
eimer
's dis
ease
im
aging
. De
fense
by R
okka
J Su
pervi
sors:
Soli
n O, R
inne J
and
Haap
aran
ta-So
lin M
Gene
ral p
ublic
Na
tiona
l, Fin
land
100
P16/T
urku
UH
Fema
le St
uden
t
10
06.02
.2015
Th
esis
defen
se (P
hD
in Bi
ology
) Fa
culty
of
Mathe
matic
s and
Na
tural
Scien
ces,
Unive
rsity
of Mü
nster
(M
ünste
r, Ge
rman
y)
Title:
Loca
lizati
on an
d Qua
ntific
ation
of
Dise
ase-
Spec
ific M
olecu
lar A
ltera
tions
in
vivo -
Mole
cular
Imag
ing S
tudies
in
Stro
ke an
d Glio
ma.
Defen
se by
Zinn
hard
t B
Supe
rviso
rs: Ja
cobs
AH
and B
ähler
M
Rese
arch
Na
tiona
l, Ge
rman
y
P01/W
WU
P0
8/CEA
Ma
le St
uden
t
11
20.02
.2015
Th
esis
defen
se (P
hD
in Ph
arma
ceuti
cal
and B
iomole
cular
Sc
ience
s)
Depa
rtmen
t of
Molec
ular
Biote
chno
logy a
nd
Healt
h Scie
nces
, Mo
lecula
r and
Pr
eclin
ical Im
aging
Ce
nter,
Unive
rsity
of To
rino (
Torin
o, Ita
ly)
Title:
Des
ign an
d tes
ting
of MR
I and
OI
prob
es fo
r im
aging
neur
oinfla
mmati
on.
Defen
se by
Gar
ello F
Su
pervi
sor:
Terre
no E
Rese
arch
Na
tiona
l, Ital
y 50
P0
5/UniT
o Fe
male
Stud
ent
12
31.03
.2015
Th
esis
defen
se (P
hD
in Me
dicine
) De
partm
ent o
f Ne
urob
iolog
y, Ca
re
Scien
ces a
nd S
ociet
y Al
zheim
er
Neur
obiol
ogy C
enter
- Ka
rolin
ska I
nstitu
tet
(Stoc
kholm
, Swe
den)
Title:
Mult
iple a
myloi
d bind
ing si
tes in
Al
zheim
er br
ain an
d the
ir inte
racti
on w
ith
syna
ptic a
nd in
flamm
atory
mech
anism
s. De
fense
by: R
uiqing
N
Supe
rviso
rs: N
ordb
erg A
, Gilb
erg P
G an
d Ma
rutle
A
Rese
arch
Na
tiona
l, Sw
eden
10
0 P1
2b/K
I Fe
male
Stud
ent
13
25.06
.2015
Th
esis
defen
se (P
hD
in Bi
ology
) Fa
culty
of
Mathe
matic
s and
Na
tural
Scien
ces,
Unive
rsity
of Mü
nster
(M
ünste
r, Ge
rman
y)
Title:
Reg
ulatio
n of A
dult N
euro
gene
sis
by N
euro
inflam
matio
n - A
Stud
y Em
ployin
g Mult
imod
al Mo
lecula
r Ima
ging
in Mi
ce.
Defen
se by
Fric
ke I
Supe
rviso
rs: Ja
cobs
AH
and B
ähler
M
Rese
arch
Na
tiona
l, Ge
rman
y
P01/W
WU
Fema
le St
uden
t
14
15.09
.2015
Th
esis
defen
se (P
hD
in Ph
arma
ceuti
cal
Scien
ces)
Facu
lty of
Ph
arma
ceuti
cal
Scien
ces,
KU Le
uven
(L
euve
n, Be
lgium
)
Title:
PET
imag
ing of
neur
oinfla
mmati
on
targe
ting t
he T
SPO
and P
2X7 r
ecep
tor.
Defen
se by
Ory
D Su
pervi
sors:
Bor
mans
G, V
erbr
ugge
n A
and D
ebys
er Z
Rese
arch
Na
tiona
l, Be
lgium
80
P1
3a/K
UL
Male
Stud
ent
15
15.10
.2015
Th
esis
defen
se
(MPh
il) Fa
culty
of M
edica
l an
d Hum
an S
cienc
es,
Unive
rsity
of Ma
nche
ster
(Man
ches
ter, U
K)
Evalu
ation
of [1
1C]P
K111
95 an
d [11
C]DA
SB po
sitro
n emi
ssion
tom
ogra
phy b
rain
scan
s in h
ealth
y co
ntrols
. De
fense
by H
ollan
d GP
Supe
rviso
rs: G
erha
rd A
, Hinz
R, T
rend
er-
Gerh
ard I
Rese
arch
Na
tiona
l, UK
P1
0a/U
niMan
Ma
le St
uden
t
16
13.11
.2015
Th
esis
defen
se (P
hD
Facu
lty of
Med
ical
Title:
Neu
roinf
lamma
tion i
n dep
ress
ion
Rese
arch
Na
tiona
l, UK
P1
0a/U
niMan
Fe
male
Stud
ent
Da
te Ty
pe
Plac
e Ti
tle
Type
of
audi
ence
Co
untri
es
addr
esse
d Si
ze o
f au
dien
ce
Partn
er re
sp./
invo
lv.
Male/
Fem
ale
Rese
arch
er
Seni
or/st
uden
t
in Ne
uros
cienc
es an
d Im
aging
Scie
nces
) an
d Hum
an S
cienc
es,
Unive
rsity
of Ma
nche
ster
(Man
ches
ter, U
K)
and s
chizo
phre
nia, m
easu
red i
n vivo
us
ing po
sitro
n emi
ssion
tomo
grap
hy
(PET
). De
fense
by H
olmes
S
Supe
rviso
rs: T
albot
P, H
inz R
and D
rake
R
17
26.01
.2016
Th
esis
defen
se (P
hD
in Lif
e Scie
nce a
nd
Healt
h, sp
ecial
ity
Imag
e Pro
cess
ing)
Facu
lty of
Med
icine
, Un
iversi
ty of
Tour
s (T
ours,
Fra
nce)
Title:
Tra
iteme
nt de
s ima
ges
multic
ompo
sante
s par
EDP
- Ap
plica
tion
à l'im
ager
ie TE
P dy
nami
que.
De
fense
by Ja
ouen
V
Supe
rviso
rs: T
aube
r C an
d Guil
lotea
u D
Rese
arch
Na
tiona
l, Fr
ance
P04/U
T Ma
le St
uden
t
18
04.03
.2016
Th
esis
defen
se (P
hD
in Ph
arma
ceuti
cal
and B
iomole
cular
Sc
ience
s)
Depa
rtmen
t of
Molec
ular
Biote
chno
logy a
nd
Healt
h Scie
nces
, Mo
lecula
r and
Pr
eclin
ical Im
aging
Ce
nter,
Unive
rsity
of To
rino (
Torin
o, Ita
ly)
Title:
Mole
cular
Imag
ing te
chniq
ues f
or
neur
ologic
al dis
ease
s visu
alisa
tion.
Defen
se by
Filip
pi M
Supe
rviso
r: Te
rreno
E
Rese
arch
Na
tiona
l, Ital
y 50
P0
5/UniT
o Fe
male
Stud
ent
19
20.04
.2016
Th
esis
defen
se (P
hD
in Bi
omed
ical
Scien
ces)
Facu
lty of
Ph
arma
ceuti
cal,
Biom
edica
l and
Ve
terina
ry Sc
ience
s, Un
iversi
ty of
Antw
erp
(Antw
erp,
Belgi
um)
Title:
Imag
ing pa
thoph
ysiol
ogica
l eve
nts
and t
hera
peuti
c mod
ulatio
n in t
he
cupr
izone
mou
se m
odel
for M
ultipl
e Sc
leros
is.
Defen
se by
Gug
lielm
etti C
Su
pervi
sors:
Van
der L
inden
A,
Pons
aerts
P
Rese
arch
Na
tiona
l, Be
lgium
P07/U
A Fe
male
Stud
ent
20
29.04
.2016
Th
esis
defen
se (P
hD
in Bi
ology
) Ins
titute
of Mo
lecula
r Re
gene
rativ
e Me
dicine
, Par
acels
us
Medic
al Un
iversi
ty (S
alzbu
rg, A
ustria
)
Title:
New
insig
hts in
to CN
S-Pe
ricyte
fun
ction
: A ro
le in
remy
elina
tion.
Defen
se by
Lang
e S
Supe
rviso
rs: B
auer
HC,
Aign
er L,
Rive
ra
FJ
Rese
arch
Na
tiona
l, Au
stria
15-2
0 P0
3/PMU
Fe
male
Stud
ent
21
25.05
.2016
Th
esis
defen
se (P
hD
in Bi
ology
) Ins
titute
of Ex
perim
ental
Ne
uror
egen
erati
on,
Para
celsu
s Med
ical
Unive
rsity
(Salz
burg
, Au
stria)
Title:
New
neur
ons i
n the
mam
malia
n br
ain: M
ethod
s and
new
insigh
ts int
o ad
ult ne
urog
enes
is.
Defen
se by
Roth
eneic
hner
P
Supe
rviso
rs: B
auer
HC,
Cou
illard
-De
spre
s S, A
igner
L
Rese
arch
Na
tiona
l, Au
stria
15-2
0 P0
3/PMU
Ma
le St
uden
t
22
02.06
.2016
Th
esis
defen
se (P
hD)
Unive
rsitei
t Utre
cht
(Utre
cht, t
he
Nethe
rland
s)
Title:
Immu
ne an
d glut
amate
syste
ms in
he
alth a
nd sc
hizop
hren
ia.
Defen
se by
Van
der D
oef T
Su
pervi
sors:
Kah
n RS,
Lamm
ertsm
a AA,
Va
n Ber
ckel
BNM
Rese
arch
Na
tiona
l, the
Ne
therla
nds
P0
9/VUA
Fe
male
Stud
ent
23
19.09
.2016
Th
esis
defen
se (P
hD
in Lif
e Scie
nce a
nd
Healt
h, sp
ecial
ity
Medic
inal C
hemi
stry)
Facu
lty of
Med
icine
, Un
iversi
ty of
Tour
s (T
ours,
Fra
nce)
Title:
Dév
elopp
emen
t de m
édica
ments
ra
dioph
arma
ceuti
ques
fluor
es po
ur
l'exp
lorati
on en
imag
erie
moléc
ulaire
TEP
de
la ne
uroin
flamm
ation
. De
fense
by E
lie J
Supe
rviso
rs: G
uillot
eau D
and V
erco
uillie
J
Rese
arch
Na
tiona
l, Fr
ance
P04/U
T Ma
le St
uden
t
Da
te Ty
pe
Plac
e Ti
tle
Type
of
audi
ence
Co
untri
es
addr
esse
d Si
ze o
f au
dien
ce
Partn
er re
sp./
invo
lv.
Male/
Fem
ale
Rese
arch
er
Seni
or/st
uden
t
24
18.10
.2016
Th
esis
defen
se (P
hD
in Ch
emist
ry)
Unive
rsity
Paris
-Sud
, Un
iversi
té Pa
ris-
Sacla
y (Sa
clay,
Fran
ce)
Title:
Syn
thesis
of no
vel li
gand
s for
im
aging
neur
oinfla
mmati
on w
ith P
ositro
n Em
ission
Tom
ogra
phy.
Defen
se by
Cac
heux
F
Supe
rviso
rs: D
ollé F
, Dam
ont A
Rese
arch
Na
tiona
l, Fr
ance
P08/C
EA
Fema
le St
uden
t
25
04.11
.2016
Th
esis
defen
se (P
hD
in Ne
uros
cienc
es an
d Im
aging
Scie
nces
)
Facu
lty of
Biol
ogy,
Medic
ine an
d Hea
lth,
Unive
rsity
of Ma
nche
ster
(Man
ches
ter, U
K)
Title:
Inve
stiga
ting I
magin
g Biom
arke
rs of
Neur
oinfla
mmati
on an
d Ne
urod
egen
erati
on in
Rod
ent M
odels
of
Alzh
eimer
’s Di
seas
e. De
fense
by C
hane
y A
Supe
rviso
rs: B
outin
H an
d Willi
ams S
Rese
arch
Na
tiona
l, UK
P1
0b/U
niMan
Fe
male
Stud
ent
26
16.11
.2016
Th
esis
defen
se (P
hD
in Im
aging
Scie
nces
) Fa
culty
of M
edica
l an
d Hum
an S
cienc
es,
Unive
rsity
of Ma
nche
ster
(Man
ches
ter, U
K)
Title:
Qua
ntitat
ive an
alysis
of po
sitro
n em
ission
tomo
grap
hy (P
ET) w
ith th
e se
cond
gene
ratio
n tra
nsloc
ator p
rotei
n (T
SPO)
ligan
d [18
F]GE
-180
. De
fense
by S
ridha
ran S
Su
pervi
sors:
Hinz
R, B
outin
H, G
erha
rd A
an
d Buc
kley C
(indu
strial
co-su
pervi
sor,
GE H
ealth
care
)
Rese
arch
Na
tiona
l, UK
P1
0a/U
niMan
Fe
male
Stud
ent
27
17.11
.2016
Th
esis
defen
se (P
hD
Neur
oscie
nces
) Un
iversi
ty of
Barce
lona (
Barce
lona,
Spain
)
Title:
Mec
anism
e sim
plica
ts en
l'acti
vació
clà
ssica
o alt
erna
tiva d
e la m
icrog
lia:
pape
r en l
a isq
uèma
i cer
ebra
l. De
fense
by B
onfil
E Su
pervi
sor:
Plan
as A
M
Rese
arch
Na
tiona
l, Sp
ain
P0
6/IDI
BAPS
Fe
male
Stud
ent
28
29.11
.2016
Th
esis
defen
se (P
hD
in Bi
omed
ical
Scien
ces)
Facu
lty of
Med
icine
, Bi
omed
ical S
cienc
es
Grou
p, KU
Leuv
en
(Leu
ven,
Belgi
um)
Title:
The
role
of CB
2 rec
eptor
s in
neur
odeg
ener
ation
. De
fense
by A
hmad
R
Supe
rviso
r: Va
n Lae
re K
Rese
arch
Na
tiona
l, Be
lgium
P13a
/KUL
Fe
male
Stud
ent
29
08.03
.2017
Th
esis
defen
se (P
hD
in Me
dicine
) Fa
culty
of M
edici
ne,
Vrije
Univ
ersit
eit
Amste
rdam
(A
mster
dam,
the
Nethe
rland
s)
Title:
Kine
tic an
alysis
and q
uanti
ficati
on
of PE
T ne
uroim
aging
stud
ies.
Defen
se by
Goll
a SS
Supe
rviso
rs: La
mmer
tsma A
A, B
oella
ard
R, Y
aqub
MM
Rese
arch
Na
tiona
l, the
Ne
therla
nds
P0
9/VUA
Ma
le St
uden
t
30
19.05
.2017
Th
esis
defen
se (P
hD
in Ps
ychia
try)
Depa
rtmen
t of C
linica
l Ne
uros
cienc
e -
Karo
linsk
a Ins
titutet
(S
tockh
olm, S
wede
n)
Title:
PET
stud
ies on
the i
mmun
e cell
ma
rker T
SPO
in firs
t epis
ode p
sych
osis
patie
nts.
Defen
se by
Coll
ste K
Su
pervi
sor:
Cerve
nka S
Rese
arch
Na
tiona
l, Sw
eden
P12a
/KI
Fema
le St
uden
t
31
16.06
.2017
Th
esis
defen
se (P
hD
in Cl
inica
l Phy
siolog
y an
d Nuc
lear
Medic
ine)
Turku
PET
Cen
tre,
Facu
lty of
Med
icine
, Un
iversi
ty of
Turku
(T
urku
, Finl
and)
Title:
Imag
ing A
lzheim
er's
disea
se be
ta-am
yloid
patho
logy i
n tra
nsge
nic m
ouse
mo
dels
using
posit
ron e
miss
ion
tomog
raph
y. De
fense
by S
nellm
an A
Su
pervi
sors:
Haa
para
nta-S
olin M
, Rinn
e J a
nd S
olin O
Gene
ral p
ublic
Na
tiona
l, Fin
land
P1
6/Tur
ku U
H Fe
male
Stud
ent
32
20.06
.2017
Th
esis
defen
se (P
hD
in Bi
omor
pholo
gical
and S
urgic
al Sc
ience
s)
Facu
lty of
Med
icine
, Un
iversi
ty Fe
deric
o II
Naple
s (Na
ples,
Italy)
Title:
In vi
vo im
aging
of T
SPO
in mo
use
mode
l of n
euro
inflam
matio
n usin
g sma
ll-an
imal
pet w
ith [1
8F]D
PA-7
14
Defen
se by
Cod
a ARD
Rese
arch
Na
tiona
l, Ital
y
P15/C
NR-IB
B Fe
male
Stud
ent
Da
te Ty
pe
Plac
e Ti
tle
Type
of
audi
ence
Co
untri
es
addr
esse
d Si
ze o
f au
dien
ce
Partn
er re
sp./
invo
lv.
Male/
Fem
ale
Rese
arch
er
Seni
or/st
uden
t
Supe
rviso
r: Pa
ppata
S
33
TBD
(July
2017
) Th
esis
defen
se
(Inter
natio
nal P
hD
cour
se in
Mole
cular
Me
dicine
, Cell
ular
and M
olecu
lar
Neur
oscie
nce
curri
culum
)
Facu
lty of
Med
icine
an
d Sur
gery,
Vita
-Sa
lute S
an R
affae
le Un
iversi
ty (M
ilan,
Italy)
Title:
In vi
vo hu
man m
olecu
lar im
aging
of
neur
oinfla
mmati
on an
d neu
rona
l injur
y in
neur
odeg
ener
ative
cond
itions
and i
ts re
lation
ship
with
patho
logy.
De
fense
by Ia
ccar
ino L
Su
pervi
sor:
Pera
ni D
Rese
arch
Na
tiona
l, Ital
y
P11/H
SR
Male
Stud
ent
34
TBD
(Aug
ust
2017
) Th
esis
defen
se (P
hD
in Me
dicine
) Fa
culty
of H
ealth
and
Medic
al Sc
ience
s, Co
penh
agen
Un
iversi
ty (C
open
hage
n, De
nmar
k)
Title:
Tra
nsloc
ator P
rotei
n Ima
ging w
ith
123I-
CLIN
DE S
PECT
- Me
thod
Deve
lopme
nt an
d Clin
ical R
esea
rch.
Defen
se by
Jens
en P
Su
pervi
sors:
Pinb
org L
H (N
RU,
Rigs
hosp
italet
, Cop
enha
gen,
Mede
n P
(Dep
t Neu
rolog
y, Bi
speb
jerg H
ospit
al,
Cope
nhag
en)
Rese
arch
Na
tiona
l, De
nmar
k
P14/N
RU-R
H Ma
le St
uden
t
35
TBD
(201
7)
Thes
is de
fense
(PhD
) Vr
ije U
niver
siteit
Am
sterd
am
(Ams
terda
m, th
e Ne
therla
nds)
Them
e: Ne
uroin
flamm
ation
trac
er
deve
lopme
nt.
Defen
se by
Jann
sen B
Su
pervi
sor:
Wind
horst
AD,
Lamm
ertsm
a AA
and V
ughts
DJ
Rese
arch
Na
tiona
l, the
Ne
therla
nds
P0
9/VUA
Fe
male
Stud
ent
36
TBD
(201
7)
Thes
is de
fense
(PhD
in
Phar
mace
utica
l Sc
ience
s)
Facu
lty of
Ph
arma
ceuti
cal
Scien
ces,
KU Le
uven
(L
euve
n, Be
lgium
)
Title:
Dev
elopm
ent o
f nov
el PE
T tra
cers
for vi
suali
satio
n of n
euro
inflam
matio
n. De
fense
by A
ttili B
Su
pervi
sor:
Borm
ans G
Rese
arch
Na
tiona
l, Be
lgium
P13a
/KUL
Ma
le St
uden
t
37
TBD
(201
7)
Thes
is de
fense
(PhD
in
Biom
edica
l Sc
ience
s)
Facu
lty of
Med
icine
, Bi
omed
ical S
cienc
es
Grou
p, KU
Leuv
en
(Leu
ven,
Belgi
um)
Title:
[18F
]FPE
B PE
T im
aging
of ce
rebr
al mG
luR5 i
n hea
lth an
d alco
hol-r
elated
be
havio
rs.
Defen
se by
Leur
quin-
Ster
k G
Supe
rviso
r: Va
n Lae
re K
Rese
arch
Na
tiona
l, Be
lgium
P13a
/KUL
Ma
le St
uden
t
3.2.
3 Ex
chan
ge o
f per
sonn
el
Table
9:
List o
f per
sonn
el ex
chan
ge.
Ho
stin
g lab
orat
ory
Orig
inal
labor
ator
y Pe
riod
of
exch
ange
To
pic
1 P2
P7
1-
6/201
2 Im
aging
of m
icrog
lia: P
rofili
ng m
icrog
lia M
2 phe
notyp
e in n
euro
dege
nera
tion:
In vit
ro an
d in v
ivo st
udies
on th
e exp
ress
ion of
M2
2 P9
(31)
P14
3-4/7
/2012
PV
Elab
educ
ation
al me
eting
, imple
menta
tion a
nd te
st of
local
Amste
rdam
PVE
lab in
stalla
tion.
Analy
sis of
PET
datas
ets fo
r pub
licati
on
3 P1
4 P0
24
/8/20
12
PVEl
ab an
alysis
of A
mster
dam
datas
et, an
alysis
and P
VE co
rrecti
on of
simu
lated
and r
eal P
ET da
tasets
4 P9
P1
4-
7/13
radio
labell
ing an
d pre
clinic
al ev
aluati
on of
new
MMP-
13 tr
acer
s
5 P1
3b
P4
3/10/2
013
prec
linica
l arte
rial b
lood s
ampli
ng te
chniq
ue
6 P1
3a
P10b
3/1
0/201
3 pr
eclin
ical a
rteria
l bloo
d sam
pling
tech
nique
7 P1
3a
P10b
3/1
0/201
3 pr
eclin
ical a
rteria
l bloo
d sam
pling
tech
nique
8 P1
3a
P10b
0/1
0/201
3 pr
eclin
ical a
rteria
l bloo
d sam
pling
tech
nique
9 P2
1 P1
3b
24-2
7/10/2
013
settin
g up p
rimar
y micr
oglia
cultu
res (
both
youn
g and
adult
)
10
P9
P11
10-1
3/02/2
014
analy
sis P
ET P
K da
ta on
neur
oinfla
mmati
on
11
P9
P11
10-1
3/02/2
014
Analy
sis P
ET P
K da
ta on
neur
oinfla
mmati
on.
12
P18a
P1
1 1/4
/-30/0
9/201
4 In
vitro
micr
oglia
l cell
mod
els fo
r TSP
O.
13
P13a
P9
(31)
24
-26/0
6/201
4; 08
-10/0
7/201
4 PE
T sc
annin
g and
autor
adiog
raph
y of P
2X7R
vecto
r mod
el ra
ts.
14
P13a
P2
3/BV-
CYCL
O 24
-26/0
6/201
4; 08
-10/0
7/201
4 Ev
alutai
on of
H4R
trac
ers i
n neu
roinf
lamma
tion m
odels
in vi
tro an
d with
PET
15
P1
P11/U
SR
19/10
-8/11
/2014
Ev
aluati
on of
tran
sloca
tor pr
otein
(TSP
O) ex
pres
sion i
n a pr
eclin
ical g
lioma
mod
el to
monit
or th
erap
y res
pons
e.
4 List of abbreviations
Table 10: List of abbreviations.
Abbreviation Explanation AAN American Academy of Neurology AD Alzheimer’s Disease ADDF Alzheimer’s Drug Discovery Foundation ALS Amyotrophic lateral sclerosis AMI Academy of Molecular Imaging
APP/PS1 Amyloid precusor protein/Presenilin 1 mouse model for AD
BBB Blood-brain barrier BLI Bioluminescence imaging BV-2 cells Microglial cell line CB2R Cannabinoid type 2 receptor CC Corpus callosum CGRP Calcitonin Gene-Related Peptide CNS Central nervous system CPZ Cuprizone DKI Diffusional kurtosis imaging DTI Diffusion tensor imaging EAE Experimental autoimmune encephalomyelitis EAE Experimental autoimmune encephalomyelitis
EAE-PLP model Remitting relapsing mouse model of MS induced by proteolipid proteins (PLP)
EANM European Association of Nuclear Medicine ECM Extracellular matrix EFNS European Federation of Neurological Societies eGFP Enhanced green fluorescent protein EMIDS European Molecular Imaging Doctoral School network ENS European Neurological Society ERA Europe research area ERα Estrogen receptor-alpha ESMI European Society for Molecular Imaging ESR European Society of Radiology FK506 Tacrolimus, immunosuppressive drug Fluc Firefly luciferase FTD Frontotemporal dementia GPs Glucan Particles GSMI Grant for Multiple Sclerosis Innovation H4R Histamine H4 receptor HD Huntington’s disease ICV Intracerebroventricular IK channels Potassium-channels IL Interleukin LC Locus coeruleus LID Levodopa-induced dyskinesia LPS Lipopolysaccharide MCI Mild cognitive impairment MJFF Michael J Fox Foudation MMP Matrix metalloproteinase MR Magnetic Resonance MS Multiple sclerosis MSC Mesenchymal stem cells
Abbreviation Explanation MTC Magnetisation transfer contrast MTLE Mesial temporal lobe epilepsy NA Noradrenaline ND Neurodegeneration NI Neuroinflammation NIND Neuroinflammation in Neurodegenerative Diseases NIRF Near infrared flurorescence
NLRP3 NACHT, LRR and PYD domains-containing protein 3, part of the Nucleotide oligomerisation domain (NOD)-like receptors (NLRs)
NR Neuroregeneration NSAID Non-steroidal anti-inflammatory drug NSC Neural stem cells OB Olfactory bulb OI optical imaging P2RY12 Purinergic receptor P2Y, G-protein coupled, 12 P2RY14 Purinergic receptor P2Y, G-protein coupled, 14 P2X7R PD Parkinson's disease PET Positron Emission Tomography PIB Pittsburgh compound B PK11195 Isoquinoline carboxamide pMCAO Permanent middle cerebral artery occlusion PPARγ Peroxisome proliferator activator receptor-gamma QoL Quality of Life QPCT Glutaminyl-peptide cyclotransferase RNA Ribonucleic acid rNSC Radial neural stem cells SCA Supervised Cluster Analysis SMB Scientific Management Board SME Small Medium-sized Enterprises SMI Society for Molecular Imaging SNM Society of Nuclear Medicine SNMMI Society of Nuclear Medicine and Molecular Imaging SPECT Single Photon Emission Computed Tomography SRS Society for Radiopharmaceutical Sciences STB Scientific Tasks Board SVZ Subventricular zone TGF-β Transforming growth factor beta TNF-α Tumour necrosis factor alpha TOPIM Hot TOPics In Molecular imaging TSPO Translocator protein WMIC World Molecular Imaging Congress WP Work package
