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133 Roche Finance Report 2008 Roche Holding Ltd, Basel — Financial Statements Roche Holding Ltd, Basel Financial Statements Income statement | in millions of CHF 2008 2007 Income Income from participations 3,390 4,121 Interest income from loans to Group companies 227 121 Interest and investment income 23 72 Other income 19 18 Total income 3,659 4,332 Expenses Financial expenses (88) (24) Administration expenses (33) (31) Other expenses (21) (22) Total expenses (142) (77) Profit for the year before taxes 3,517 4,255 Taxes (18) (17) Net profit for the year 3,499 4,238

Roche Holding Ltd, Basel — Financial Statements

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Page 1: Roche Holding Ltd, Basel — Financial Statements

133Roche Finance Report 2008Roche Holding Ltd, Basel — Financial Statements

Roche Holding Ltd, Basel

Financial Statements

Income statement | in millions of CHF

2008 2007

Income

Income from participations 3,390 4,121

Interest income from loans to Group companies 227 121

Interest and investment income 23 72

Other income 19 18

Total income 3,659 4,332

Expenses

Financial expenses (88) (24)

Administration expenses (33) (31)

Other expenses (21) (22)

Total expenses (142) (77)

Profit for the year before taxes 3,517 4,255

Taxes (18) (17)

Net profit for the year 3,499 4,238

Page 2: Roche Holding Ltd, Basel — Financial Statements

134 Roche Finance Report 2008 Roche Holding Ltd, Basel — Financial Statements

Balance sheet at 31 December | in millions of CHF

2008 2007

Non-current assets

Participations 4,580 4,558

Long-term loans to Group companies 4,509 4,571

Total non-current assets 9,089 9,129

Current assets

Short-term loans to Group companies 3,000 –

Accounts receivable from Group companies 67 11

Other accounts receivable 1 1

Marketable securities 91 3,609

Liquid funds – –

Total current assets 3,159 3,621

Total assets 12,248 12,750

Equity

Share capital 160 160

Non-voting equity securities (Genussscheine) p.m. p.m.

General legal reserve 300 300

Free reserve 5,519 5,251

Special reserve 2,152 2,152

Available earnings:

— Balance brought forward from previous year 2 –

— Net profit for the year 3,499 4,238

Total equity 11,632 12,101

Non-current liabilities

Provisions 35 35

Total non-current liabilities 35 35

Current liabilities

Accounts payable to Group companies 559 588

Unrealised foreign currency gains – 4

Other liabilities 22 22

Total current liabilities 581 614

Total liabilities 616 649

Total equity and liabilities 12,248 12,750

p.m. = pro memoria. Non-voting equity securities have no nominal value.

Page 3: Roche Holding Ltd, Basel — Financial Statements

135Roche Finance Report 2008Roche Holding Ltd, Basel — Notes to the Financial Statements

Notes to the Financial Statements

1. Summary of significant accounting policiesBasis of preparation of the financial statementsThe financial statements of Roche Holding Ltd, Basel, are prepared in accordance with the provisionsof Swiss law.

ParticipationsThe major participations of the company are listed in Note 34 to the Roche Group Consolidated FinancialStatements.

Valuation methods and translation of foreign currenciesMarketable securities are reported at the lower of cost or market value. All other assets, including partici-pations, are reported at cost less appropriate write-downs. Assets and liabilities denominated in foreigncurrencies are translated into Swiss francs using year-end rates of exchange, except participations which aretranslated at historical rates. Transactions during the year which are denominated in foreign currenciesare translated at the exchange rates effective at the relevant transaction dates. Resulting exchange gains andlosses are recognised in the income statement with the exception of unrealised gains which are deferred.

TaxesThe tax charge includes corporate income and capital taxes.

2. EquityShare capitalAs in the previous year, share capital amounts to 160 million Swiss francs. The share capital consists of160,000,000 bearer shares with a nominal value of 1 Swiss franc each. Included in equity are 702,562,700non-voting equity securities (Genussscheine). They are not part of the share capital and confer no votingrights. However each non-voting equity security (Genussschein) confers the same rights as any of the sharesto participate in the available earnings and in any remaining proceeds from liquidation following repaymentof the nominal value of the share capital and, if any, participation certificates.

Page 4: Roche Holding Ltd, Basel — Financial Statements

136 Roche Finance Report 2008 Roche Holding Ltd, Basel — Notes to the Financial Statements

Movement in recognised amounts | in millions of CHF

General Share legal Free Special Available Total

capital reserve reserve reserve earnings equity

As at 1 January 2006 160 300 4,414 2,152 2,394 9,420

— Net income – – – – 3,533 3,533

— Dividends paid – – – – (2,157) (2,157)

— Transfer to free reserve – – 233 – (233) –

As at 31 December 2006 160 300 4,647 2,152 3,537 10,796

— Net income – – – – 4,238 4,238

— Dividends paid – – – – (2,933) (2,933)

— Transfer to free reserve – – 604 – (604) –

As at 31 December 2007 160 300 5,251 2,152 4,238 12,101

— Net income – – – – 3,499 3,499

— Dividends paid – – – – (3,968) (3,968)

— Transfer to free reserve – – 268 – (268) –

As at 31 December 2008 160 300 5,519 2,152 3,501 11,632

3. Contingent liabilitiesGuaranteesWithin the framework of the European Medium Term Note (EMTN) programme the company has issued guar-antees in favour of Group companies amounting to 420 million Swiss francs (2007: 1,987 million Swiss francs).

4. Significant shareholdersAll shares in the Company are bearer shares, and for this reason the Company does not keep a registerof shareholders. The following figures are based on information from shareholders, the shareholder validationcheck at the Annual General Meeting of 4 March 2008 and on other information available to the Company.

80,020,000 (2007: 80,020,000) shares: Shareholder group with pooled voting rights, comprising Ms VeraMichalski-Hoffmann, Ms Maja Hoffmann, Mr André Hoffmann, Dr Andreas Oeri, Ms Sabine Duschmalé-Oeri,Ms Catherine Oeri, Ms Beatrice Oeri and Ms Maja Oeri. a), b)

53,332,863 (2007: 53,332,863) shares (participation below 331⁄3%): Novartis Ltd, Basel including affiliatesthereof. c)

a) Information supplied by the shareholders. This figure of 80,020,000 shares does not include shares without pooled voting rights heldoutside this group by individual members of the group.

b) On 28 January 2009 the pool members announced that, effective 1 April 2009, Ms Beatrice Oeri would leave the pool and that Mr JörgDuschmalé and Mr Lukas Duschmalé would join the pool. The group would continue to hold a total 80,020,000 shares with pooledvoting rights as previously.

c) Figures as of 31 December 2008 supplied by Novartis Ltd, Basel.

Page 5: Roche Holding Ltd, Basel — Financial Statements

137

5. Risk managementThe detailed disclosures regarding risk management that are required by Swiss law are included in theRoche Group Consolidated Financial Statements on pages 107—113.

6. Board and Executive remunerationBoard of DirectorsMembers of the Board of Directors of Roche Holding Ltd receive an annual remuneration and payment fortheir time and expenses related to their membership of Board committees.

Remuneration of members of the Board of Directors | in thousands of CHF

2008 2007

B. Gehrig 409 450

A. Hoffmann 400 400

P. Baschera 330 277

J. I. Bell 330 593

P. Brabeck-Letmathe 300 300

L. J.R. de Vink 330 330

W. Frey 360 360

D.A. Julius 360 360

A. Oeri 360 360

W. Ruttenstorfer 330 277

H. Teltschik 391 392

B. Weder di Mauro 360 360

Total remuneration of Board of Directors 4,260 4,459

The Chairman of the Board of Directors, Dr Franz B. Humer, received remuneration in 2008 as shown in thetable below.

Remuneration of the Chairman of the Board of Directors | in thousands of CHF

2008

Annual salary, including bonuses and expenses 11,030

Pensions and other post-employment benefits 2,956

Equity compensation plans 983

Other employee benefits 260

Total remuneration received 15,229

Social security costs 1,521

Total 16,750

In 2007 Dr Humer received remuneration, indirect benefits and participated in certain equity compensationplans totalling 22 million Swiss francs.

Corporate Executive CommitteeMembers of the Corporate Executive Committee (‘CEC’) of Roche Holding Ltd receive remuneration, indirectbenefits and participate in certain equity compensation plans as shown in the table below. On 4 March 2008Dr Franz B. Humer handed over his executive function as CEO to Dr Severin Schwan. Since Dr Schwanwas the member of the Corporate Executive Committee with the highest total remuneration in 2008 his remu-neration is also disclosed. In 2007 Dr Humer was the member of the Corporate Executive Committee withthe highest total remuneration in 2007.

Page 6: Roche Holding Ltd, Basel — Financial Statements

138 Roche Finance Report 2008 Roche Holding Ltd, Basel — Notes to the Financial Statements

Remuneration of the members of the Corporate Executive Committee in 2008 | in thousands of CHF

— of which Total CEC a) S. Schwan

Annual salary, including bonuses and expenses 21,384 5,313

Pensions and other post-employment benefits 2,422 202

Equity compensation plans 12,557 2,493

Other employee benefits 145 11

Total remuneration received 36,508 8,019

Social security costs 1,777 287

Total 38,285 8,306

a) Amounts for the total CEC for 2008 do not include Dr Humer.

In 2007 the total remuneration of the Corporate Executive Committee was 53 million Swiss francs. Dr Humerwas the member of the Corporate Executive Committee with the highest total remuneration in 2007, with atotal remuneration of 22 million Swiss francs.

Employer contribution to social security schemes and pension plans | The Group pays social insurancecontributions in respect of the above remuneration and pays contributions to pension and other post-employment benefit plans for the Chairman of the Board of Directors and members of the Corporate ExecutiveCommittee.

Equity Compensation Plans | The Chairman of the Board of Directors and members of the CorporateExecutive Committee also participate in certain equity compensation plans as described below. The termsand vesting conditions of these awards are disclosed in Note 11 to the Consolidated Financial Statements.The fair values used in the Consolidated Financial Statements represent the cost to the company at grantdate and reflect amongst other matters the observed exercise behaviour and exit rate for the whole popula-tion that receive them and initial simulations of any performance conditions. For the purposes of theseremuneration disclosures the fair values are calculated based on the fair value that the employee receivestaking into account the preliminary assessment of any completed performance conditions.

The Chairman of the Board of Directors and members of the Corporate Executive Committee are eligible toparticipate in Roche Connect, a programme that enables employees to make regular deductions from theirsalaries to purchase non-voting equity securities. The Group contributes to the programme, which allows theemployees to purchase non-voting equity securities at a discount (usually 20%).

During 2008 members of the Corporate Executive Committee were granted 494,097 Stock-settled StockAppreciation Rights (S-SARs). The individual awards relating to 2008 are shown in the table below. The fairvalue of these awards for the employee is 21.08 Swiss francs, which is calculated using the Black-Scholesformula, assuming holding until maturity, and deducting 11% for the average 2 year vesting period. The Chairman of the Board of Directors was not granted S-SARs during 2008.

Members of the Corporate Executive Committee and other members of senior management participate in theRoche Performance Share Plan (PSP). The Group has three overlapping three-year PSPs. The target awardsfor the three-year cycle are defined at the beginning of the cycle and the awards are considered to formpart of the employee’s remuneration in three equal annual amounts over the three-year cycle. Each awardwill result in between zero and two non-voting equity securities (Genussscheine), depending upon theachievement of the performance targets, and the discretion of the Board of Directors. The individual awardsrelating to 2008 are shown in the table below. The number of the awards is calculated as follows:

• PSP 2006—2008: A preliminary allocation based on the actual performance for the period 2006 to 2008,which shows 0.75 non-voting equity security (Genussschein) per award.

• PSP 2007—2009: One non-voting equity security (Genussschein) per award.

• PSP 2008—2010: One non-voting equity security (Genussschein) per award.

Page 7: Roche Holding Ltd, Basel — Financial Statements

139

• The resulting allocations are multiplied by the non-voting equity security (Genussschein) price at31 December 2008 of 162.50 Swiss francs to give the fair value for the remuneration received by theemployee.

The Chairman of the Board of Directors was not granted PSPs for the 2008—2010 cycle.

Remuneration from equity compensation plans in 2008 | in thousands of CHF

Roche Connect S-SAR awards PSP awardsEmployer S-SAR ’08 S-SAR ’08 PSP ’06—’08 PSP ’07—’09 PSP ’08—’10 PSP Total

contributions (number) fair value (number) (number) (number) fair value fair value

Total CEC a) 191 494,097 10,416 8,739 12,459 14,805 1,950 12,557

— of which

S. Schwan 49 105,576 2,226 838 1,218 1,965 218 2,493

a) Amounts for the total CEC for 2008 do not include Dr Humer.

In 2007 the total remuneration of the Corporate Executive Committee from equity compensation plans was22 million Swiss francs, of which 9 million Swiss was attributable to Dr Humer, the member of the CorporateExecutive Committee with the highest total remuneration.

Other employee benefits | This includes tax advisory costs, and remuneration of Dr Hunziker, Mr Burns andProf. Knowles for serving on the Chugai Board of Directors.

Transactions with former members of the Corporate Executive Committee | Pensions totalling 2 millionSwiss francs were paid by the Group in 2008 to two other former Corporate Executive Committee members(2007: 2 million Swiss francs). In 2007 Mr Heino von Prondzynski, a former member of the CorporateExecutive Committee, received a bonus of 0.4 million Swiss francs in respect of services rendered in 2006and additionally received a total of 12,212 non-voting equity securities based on pro-rated RochePerformance Share Plan awards.

7. Board and Executive shareholdingsBoard of DirectorsDirectors Mr André Hoffmann and Dr Andreas Oeri and other members of the founder’s families who areclosely associated with them belong to a shareholder group with pooled voting rights. At the end of 2008 thisgroup held 80,020,000 shares (50.01% of issued shares). Detailed information about this group is given inNote 4. In addition, as of 31 December 2008 the members of the Board of Directors and persons closelyassociated with them held shares and non-voting equity securities (Genussscheine) as shown in the tablebelow.

Page 8: Roche Holding Ltd, Basel — Financial Statements

140 Roche Finance Report 2008 Roche Holding Ltd, Basel — Notes to the Financial Statements

Shareholdings of members of the Board of Directors

Non-votingequity securities

Shares (Genussscheine) Other2008 2007 2008 2007

F.B. Humer 3 3 153,919 58,886 b)

B. Gehrig 50 50 50 50

A. Hoffmann – a) – a) 365,200 c) 365,200 c), d)

P. Baschera 1 1 – –

J. I. Bell 300 300 1,647 1,647

P. Brabeck-Letmathe 800 800 2,195 2,195

L. J.R. de Vink – – – – e)

W. Frey 72,500 72,500 – –

D.A. Julius 350 350 1,550 1,250

A. Oeri 90,000 a) 90,000 a) 1,640,460 1,640,460 d)

W. Ruttenstorfer 1,000 1,000 – –

H. Teltschik 385 385 – –

B. Weder di Mauro 200 200 – –

Total 165,589 a) 165,589 a) 2,165,021 2,069,688

a) Figure does not include shares held in the shareholder group with pooled voting rights.b) Equity compensation awards: Roche Option Plan, S-SARs and Roche Performance Share Plan. See below.c) As reported to the Swiss Exchange on 21 August 2008, Mr Hoffmann entered into a call options agreement with UBS on 365,000 Roche

non-voting equity securities for the period 21 August 2008—20 August 2010.d) Mr Hoffmann and Dr Oeri each hold 250,000 UBS Long/Short Certificates on Roche bearer shares (RO) versus Roche non-voting

equity securities (ROG), (ISIN: CH0026480100).e) Mr de Vink holds 1,000 Roche American Depositary Receipts (ADRs) RHHBY (ISIN: US7711951043).

Corporate Executive CommitteeMembers of the Corporate Executive Committee and persons closely associated with them held shares andnon-voting equity securities (Genussscheine) as shown in the table below.

Shareholdings of members of the Corporate Executive Committee

Non-votingequity securities

Shares (Genussscheine) Other2008 2007 2008 2007

S. Schwan 3 3 9,468 2,148 a), b)

S. Ayyoubi 3 n/a 7,161 n/a a)

W.M. Burns 3 3 53,460 34,249 a)

E. Hunziker 3 3 43,839 19,928 a)

G.A. Keller 1,063 253 21,854 11,625 a), c)

J.K.C. Knowles 3 3 33,065 27,366 a)

J. Schwiezer 3 n/a 10,960 n/a a)

Total 1,081 265 179,807 95,316

a) Equity compensation awards: Roche Option Plan, S-SARs and Roche Performance Share Plan. See below.b) Dr Schwan’s close relatives hold 270 Roche non-voting equity securities (Genussscheine) (2007: zero).c) Dr Keller’s close relatives hold 140 Roche non-voting equity securities (Genussscheine) (2007: 210).

At 31 December 2008 the Chairman of the Board of Directors and members of the Corporate ExecutiveCommittee held Stock-settled Stock Appreciation Rights (S-SARs, first issued in 2005) and Roche OptionPlan awards (issued before 2005) as shown in the table below. Each option entitles the holder to purchaseone Roche non-voting equity security (Genussscheine) at a specified strike price. The terms and vestingconditions of these awards are disclosed in Note 11 to the Consolidated Financial Statements and additionalsupplementary information is in the Remuneration Report, which is included in the Business Report onpages 75—85.

Page 9: Roche Holding Ltd, Basel — Financial Statements

141

Roche Option Plan and S-SARs awards held at 31 December 2008

Year of issue 2008 2007 2006 2005 2004 2003 2002 Total

S. Schwan 105,576 29,190 15,696 4,983 1,864 1,635 – 158,944

S. Ayyoubi 21,117 3,243 2,517 3,957 2,360 2,324 1,900 37,418

W.M. Burns 105,576 48,651 26,160 34,074 14,874 17,353 – 246,688

E. Hunziker 92,907 48,651 26,160 34,074 20,915 – – 222,707

G.A. Keller 63,345 24,327 15,696 3,150 4,000 – – 110,518

J.K.C. Knowles 63,345 24,327 15,696 – – – – 103,368

J. Schwiezer 42,231 9,819 5,565 8,871 5,610 3,065 – 75,161

Total CEC 494,097 188,208 107,490 89,109 49,623 24,377 1,900 954,804

F.B. Humer – 48,651 52,317 85,179 55,775 – – 241,922

Total 494,097 236,859 159,807 174,288 105,398 24,377 1,900 1,196,726

Strike price (CHF) 195.80 229.60 195.00 123.00 129.50 77.80 115.50

Expiry date Jan. 2015 Feb. 2014 Feb. 2013 Feb. 2012 Feb. 2011 Feb. 2010 Feb. 2009

At 31 December 2008 the Chairman of the Board of Directors and members of the Corporate Executive Com-mittee held PSP awards from the three PSP performance cycles 2006—2008, 2007—2009 and 2008—2010 asshown in the table below. The terms and vesting conditions of these awards are disclosed in Note 11 to theConsolidated Financial Statements and additional supplementary information is in the Remuneration Report onpages 75—85 of the Business Report. Each award will result in between zero and two non-voting equity secu-rities (Genussscheine), depending upon the achievement of the performance targets and the discretion of theBoard of Directors. The preliminary allocation ratio for the plan 2006—2008 and the total target numberof awards for all cycles as at 31 December 2008 are shown in the table below.

Roche Performance Share Plan awards held at 31 December 2008

PSP 2006—2008 PSP 2007—2009 PSP 2008—2010

S. Schwan 1,117 1,218 1,965

S. Ayyoubi 550 507 638

W.M. Burns 2,578 3,046 3,276

E. Hunziker 2,750 3,046 3,276

G.A. Keller 1,203 1,370 1,474

J.K.C. Knowles 2,148 2,056 2,211

J. Schwiezer 1,304 1,216 1,965

Total CEC 11,650 12,459 14,805

F.B. Humer 10,365 9,185 –

Total awards granted 22,015 21,644 14,805

Allocation date Feb. 2009 Feb. 2010 Feb. 2011

Estimated allocation at 31 December 2008 0.75 :1

Total estimated awards at 31 December 2008 16,513

At 31 December 2007 the Chairman of the Board of Directors and members of the Corporate Executive Com-mittee at that time held a total of 684,061 Stock-settled Stock Appreciation Rights and Roche Option Planawards, and had outstanding a total of 125,224 awards granted under the Roche Performance Share Plan.

Page 10: Roche Holding Ltd, Basel — Financial Statements

142 Roche Finance Report 2008 Roche Holding Ltd, Basel — Appropriation of Available Earnings

Appropriation of Available Earnings

Proposals to the Annual General Meeting | in CHF

2008 2007

Available earnings

Balance brought forward from previous year 1,832,184 520,281

Net profit for the year 3,498,521,585 4,237,700,323

Transfer from free reserve 813,050,000 –

Total available earnings 4,313,403,769 4,238,220,604

Appropriation of available earnings

Distribution of an ordinary dividend of CHF 5.00 gross

per share and non-voting equity security (Genussschein)

as against CHF 4.60 last year (4,312,813,500) (3,967,788,420)

Transfer to free reserve – (268,600,000)

Total appropriation of available earnings (4,312,813,500) (4,236,388,420)

To be carried forward on this account 590,269 1,832,184

Page 11: Roche Holding Ltd, Basel — Financial Statements

143Roche Finance Report 2008Roche Holding Ltd, Basel — Report of the Statutory Auditor on the Financial Statements

Report of the Statutory Auditor on the Financial Statements

Report of the Statutory Auditor on the Financial Statements to the Annual General Meeting of Roche Holding Ltd, BaselAs statutory auditor, we have audited the financial statements (income statement, balance sheet and noteson pages 133 to 142) of Roche Holding Ltd for the year ended 31 December 2008.

Board of Directors’ Responsibility | The Board of Directors is responsible for the preparation of the finan-cial statements in accordance with the requirements of Swiss law and the company’s articles of incorporation.This responsibility includes designing, implementing and maintaining an internal control system relevant to the preparation of financial statements that are free from material misstatement, whether due to fraud or error.The board of directors is further responsible for selecting and applying appropriate accounting policies andmaking accounting estimates that are reasonable in the circumstances.

Auditor’s Responsibility | Our responsibility is to express an opinion on these financial statements based onour audit. We conducted our audit in accordance with Swiss law and Swiss Auditing Standards. Those stan-dards require that we plan and perform the audit to obtain reasonable assurance whether the financial state-ments are free from material misstatement.

An audit involves performing procedures to obtain audit evidence about the amounts and disclosures in thefinancial statements. The procedures selected depend on the auditor’s judgment, including the assessment ofthe risks of material misstatement of the financial statements, whether due to fraud or error. In making thoserisk assessments, the auditor considers the internal control system relevant to the entity’s preparation of thefinancial statements in order to design audit procedures that are appropriate in the circumstances, but not forthe purpose of expressing an opinion on the effectiveness of the entity’s internal control system. An audit alsoincludes evaluating the appropriateness of the accounting policies used and the reasonableness of account-ing estimates made, as well as evaluating the overall presentation of the financial statements. We believe thatthe audit evidence we have obtained is sufficient and appropriate to provide a basis for our audit opinion.

Opinion | In our opinion, the financial statements for the year ended 31 December 2008 comply with Swisslaw and the company’s articles of incorporation.

Page 12: Roche Holding Ltd, Basel — Financial Statements

144 Roche Finance Report 2008 Roche Holding Ltd, Basel — Report of the Statutory Auditor on the Financial Statements

Report on Other Legal RequirementsWe confirm that we meet the legal requirements on licensing according to the Auditor Oversight Act (AOA)and independence (article 728 CO and article 11 AOA) and that there are no circumstances incompatible withour independence.

In accordance with article 728a paragraph 1 item 3 CO and Swiss Auditing Standard 890, we confirm that aninternal control system exists, which has been designed for the preparation of financial statements accordingto the instructions of the Board of Directors.

We further confirm that the proposed appropriation of available earnings complies with Swiss law and thecompany’s articles of incorporation. We recommend that the financial statements submitted to you beapproved.

KPMG Klynveld Peat Marwick Goerdeler SA

John A. Morris François RouillerLicensed Audit Expert Licensed Audit ExpertAuditor in Charge

Basel, 29 January 2009

Page 13: Roche Holding Ltd, Basel — Financial Statements
Page 14: Roche Holding Ltd, Basel — Financial Statements

Published byF. Hoffmann-La Roche Ltd4070 Basel, SwitzerlandTel. +41 (0)61 688 11 11Fax +41 (0)61 691 93 91

Media OfficeCorporate Communications 4070 Basel, SwitzerlandTel. +41 (0)61 688 88 88Fax +41 (0)61 688 27 75

Investor Relations4070 Basel, SwitzerlandTel. +41 (0)61 688 88 80Fax +41 (0)61 691 00 14

World Wide Webhttp://www.roche.com

To order publicationsTel. +41 (0)61 688 83 39Fax +41 (0)61 688 43 43E-mail: [email protected]

Next Annual General Meeting: 10 March 2009

Cautionary statement regarding forward-lookingstatementsThis Annual Report contains certain forward-lookingstatements. These forward-looking statements may be identi-fied by words such as ‘believes’, ‘expects’, ‘anticipates’,‘projects’, ‘intends’, ‘should’, ‘seeks’, ‘estimates’, ‘future’ orsimilar expressions or by discussion of, among other things,strategy, goals, plans or intentions. Various factors maycause actual results to differ materially in the future from thosereflected in forward-looking statements contained in thisAnnual Report, among others: (1) pricing and productinitiatives of competitors; (2) legislative and regulatory devel-opments and economic conditions; (3) delay or inability inobtaining regulatory approvals or bringing products to market;(4) fluctuations in currency exchange rates and generalfinancial market conditions; (5) uncertainties in the discovery,development or marketing of new products or new uses ofexisting products, including without limitation negative resultsof clinical trials or research projects, unexpected side effectsof pipeline or marketed products; (6) increased governmentpricing pressures; (7) interruptions in production; (8) lossof or inability to obtain adequate protection for intellectualproperty rights; (9) litigation; (10) loss of key executivesor other employees; and (11) adverse publicity and newscoverage.

The statement regarding earnings per share growth is nota profit forecast and should not be interpreted to meanthat Roche’s earnings or earnings per share for 2008 or anysubsequent period will necessarily match or exceed thehistorical published earnings or earnings per share of Roche.

All trademarks mentioned enjoy legal protection.

The Roche Annual Report is published in German and English.

Printed on non-chlorine bleached, FSC-certified paper.

The Roche Annual Report is issued by F. Hoffmann-La Roche Ltd, Basel, Corporate Communications.

Page 15: Roche Holding Ltd, Basel — Financial Statements

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