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Richard L. HuganirDepartment of Neuroscience
Johns Hopkins University School of Medicine Howard Hughes Medical Institute
Making and Erasing Memories
The Brain is a Network of 100 Billion Neurons
The Brain has Quadrillions of Synapses
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Synaptic Transmission
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Synaptic Plasticity at Synapses
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Synaptic Plasticity at Synapses
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Synaptic Plasticity at Synapses
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Synaptic Plasticity at Synapses
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Long-Term Potentiation
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Long-Term Depression
Regulation of Receptor Function
Kibra
Beautiful Synapses
Cranial Window
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Imaging Receptors in Live Mice
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0 hour 1 hour 2 hour 3 hour
Control
Stimulation
Sensory Stimulation Recruits Receptors to Synapses
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Spatial Learning - Water Maze
Before Training After Training
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Fear Learning and Memory - Fear Conditioning
Fear Extinction: a Form of Behavioral Therapy
Extinction Learning
Extinction RetrievalExtinction Learning
Fear Extinction: a Form of Behavioral Therapy
RelapseExtinction RetrievalExtinction Learning
Fear Extinction: a Form of Behavioral Therapy
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Synaptic Plasticity During Fear Learning
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24 Hrs after Fear Learning
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7 Days after Fear Learning
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24 Hrs window after Fear ConditioningmGluR1-Dependent LTD
Ro-0711401: 9H-xanthene-9-carboxylic acid (4-trifluoromethyl-oxazol-2-yl)-amide
Positive Allosteric Modulators of mGluR1
PAM
Regulation of Receptor Function
Kibra
Yoichi ArakiShu-Ling ChiuMonica Coulter
Kirsten BombachMin Dai
Graham DieringHuaqiang Fang
Hana GoldschmidtAhleah Gustina
Lisa Hamm Seok HeoIngie Hong
Natasha Hussain Richard Johnson
Olof LagerlofTrisha Lala Brain Loeper
Bian LiuRichard Roth Raja Sekhar
Kamal SharmaGek Ming SiaMengnan Tian Alyssa TodaLenora Volk
Rebecca WhiteYong Zhang
Huganir Lab
Funding
HHMININDSNIMH
Simons FoundationADRC Pilot Grant