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RESUME
Name Soheila Rahgozar Address Dr Soheila Rahgozar Department of Biology Faculty of Science University of Isfahan ISFAHAN 81744 IRAN Phone: +98-31-37932365 (Off.) Fax: +98-31-37932455 (Dept.Off.) E-Mail: [email protected] http://sci.ui.ac.ir/~rahgozar Scopus Author ID: 15766272400
Orcid: orcid.org/0000-0003-1376-255X
Google Scholar: https://scholar.google.com/citations?user=VrF0NRQAAAAJ&hl=en
ResearcherID: T-7240-2017
Education
Degree Year
B.Sc. School/University:Shahid Beheshti University
Tehran-Iran
Sep 1988
M.Sc. School/University:Tarbiat Modares-Tehran/Iran
Dissertation title: Evaluation of Beta S Gene in
Central Iran
Supervisor: Prof. Pourfathollah
Sep 1999
Ph.D. School/University: University of New South
Wales- Sydney/Australia
Thesis title: Studies On Beta 2 Glycoprotein I And Antiphospholipid Antibodies
Supervisor: Prof. Steven Krilis
March 2008
Experience
Organization Position Duration
Department of Biology
Faculty of Science
Isfahan University
Isfahan, IRAN
Assistant Professor Sep. 2009-Present
Department of Immunology,
University of New South Wales,
Education and Research Centre,
Sydney, Australia
Research officer
(Post doctorate) 2007-2009
Division of Bone Marrow Transplant,
Prince of Wales Hospital,
Sydney, Australia
Research Scholar
(Post doctorate) 2008-2009
Division of Haematology,
Prince of Wales Hospital,
Sydney, Australia
Research Scholar
(Post doctorate) 2008-2009
Division of Coagulation,
Laboratory of Haematology, St. George
Hospital,
Research Scholar
(Post doctorate) 2008-2009
Photo
Sydney, Australia
Department of Immunology,
University of New South Wales,
Education and Research Centre,
Sydney, Australia
Research Scholar
(Ph.D. Student) 2005-2008
Division of Special Serology Tests,
Esfahan Blood Transfusion Centre,
Esfahan, Iran
Laboratory expert 2001-2005
Division of Microscopic Haematology,
Pediatric Hematology- Oncology Private
Clinic,
Esfahan, Iran
Laboratory expert 2000-2005
Falavarjan Azad University,
Esfahan, Iran
Lecturer 2000-2002
Expertise Areas
Molecular cell biology
o Cell culture
o PCR, RT-PCR, DNA electrophoresis and DNA purification
o Gene cloning
o Expression of the Flag-tagged recombinant proteins in mammalian cells
o Expression of the 6His-tagged recombinant proteins, using Baculo virus system in
insect cells
o Purification of recombinant proteins using anti-Flag and Ni-NTA
o Gene mutation
Mice studies
Microscopic Haematology
Stem cell harvest, cryopreservation, cell isolation
ELIZA, Western blot, SDS-PAGE
Purification of proteins using ion exchange, gel filtration, and affinity chromatography
Chromogenic assays
Enzymatic assays
Platelet adhesion and aggregation studies
Platelet release studies using radio labeled 14C-5HT
Iodination
Research Interests
Leukemia and multidrug resistance
Hemoglobinopathies
Redox proteomics
Awards and Recognitions
2018 Excellence in Teaching award (University of Isfahan)
2017 Award winner for the best book of the year announced by University of
Isfahan; Rahgozar S, Abedi M, Khosravi-Dehaghi Z, Aberuyi N (2016) MicroRNAs:
Identification and application (Persian). University of Isfahan.
2016 Award winner for the best book of 2 years announced by the Ministry
of Culture and Islamic Guidance; Rahgozar S, Ghaedi K (2014) Stem cells and tissue regeneration (Persian). University
of Isfahan.
2016 Excellence in Science and Technology award (University of Isfahan)
2008 Selected article for the editorial; Koike T, Atsumi T (2007). “Resurrection of thrombin” in the pathophysiology of the
antiphospholipid syndrome. Arthritis & Rheumatism. 56(2): 393-394.
2008 Nominee for the best medical paper of the year 2007 award (Amedeo Prize); Giannakopoulos B, Passam P, Rahgozar S, Krilis S.A (2007). Current concepts on the
pathogenesis of the antiphospholipid syndrome. Blood. 109: 422-430.
2008 Full mark PhD thesis entitled ‘Studies on beta 2 glycoprotein I and
antiphospholipid antibodies’
2003 The SO.S.T.E award of Outstanding Young investigator
1999 Full mark MSc thesis as a unique study on hemoglobin S gene in Iran
Publications Journal Publication
Elaheh Sadat Ghodousi, Soheila Rahgozar. MicroRNA-326 and microRNA-200c: biomarkers with
novel roles in diagnosis and prognosis of pediatric acute lymphoblastic leukemia (2018). Journal of
cellular Biochemistry. 119(7):6024-6032. ISI Impact Factor 3.085
Fakhimikabir H, Tavakoli MB, Zarrabi A, Amouheidari A, Rahgozar S.The role of folic acid-
conjugated polyglycerol coated iron oxide nanoparticles on radiosensitivity with clinical electron beam
(6 MeV) on human cervical carcinoma cell line: In vitro study (2018). J Photochemistry and
Photobiology. B,Biology. 182:71-76. ISI Impact Factor 2.7
Ghodousi E.S, Rahgozar S. Recovery of microRNA from stored patient bone marrow aspirate slides
(2018). Avicenna journal of medical Biotechnology. Accepted for publication
Abedi M, Rahgozar S. Significance and applications of murine models in cancer research; Guidelines
for selecting the best model (Persian with English abstract) (2017). J Mazandaran Uni Med Sci. 27 (154): 212-23127 (154): 212-231
Moafi A, Ziaie M, Abedi M, Rahgozar S, Reisi N, Nematollahi P, Moafi H. The relationship between
iron bone marrow stores and response to treatment in pediatric acute lymphoblastic leukemia.
Medicine (Baltimore). 2017 Nov;96(44):e8511. ISI Impact Factor 1.803
Moafi A, Zojaji A, Salehi R, Najafi Dorcheh S, Rahgozar S. The correlation between Pax5 deletion
and patients survival in Iranian children with precursor B-cell acute lymphocytic leukemia (2017). Cell
Mol Biol (Noisy-le-grand). 63(8):19-22. ISI Impact Factor 0.94
Narges Aberuyi, Soheila Rahgozar, Zohreh Khosravi Dehaghi, Alireza Moafi, Andrea Masotti,
Alessandro Paolini.The translational expression of ABCA2 and ABCA3 is a strong prognostic
biomarker for multidrug resistance in pediatric acute lymphoblastic leukemia (2017). OncoTargets and
Therapy. 10: 3373-3390. ISI Impact Factor 2.73
Yarjanli Z, Ghaedi K, Esmaeili A, Rahgozar S, Zarrabi A. Iron oxide nanoparticles may damage to
the neural tissue through iron accumulation, oxidative stress, and protein aggregation (2017). BMC
Neurosci. 18(1):51. ISI Impact Factor 2.312
Mesrian Tanha H, Rahgozar S, Mojtabavi Naeini M.ABCC4 functional SNP in the 3' splice acceptor
site of exon 8 (G912T) is associated with unfavorable clinical outcome in children with acute
lymphoblastic leukemia (2017). Cancer Chemother Pharmacol. 80:109-117. ISI Impact Factor 2.824
Safavi A, Emamzadeh R, Nazari M, Ehsani M, Zarkesh-Esfahani SH, Rahgozar S. Super RLuc8-sFv;
a new luciferase-labeled probe for detection of human CD4+ cells (2017). Mol Biosyst. 13(3):470-475.
ISI Impact Factor 2.829
Jodeiri Farshbaf M, Forouzanfar M, Ghaedi K, Kiani-Esfahani A, Peymani M, Shoaraye Nejati A,
Izadi T, Karbalaie K, Noorbakhshnia M, Rahgozar S, Baharvand H, Nasr-Esfahani MH. Nurr1 and
PPARγ protect PC12 cells against MPP+ toxicity: involvement of selective genes, anti-inflammatory,
ROS generation, and antimitochondrial impairment (2016). Mol Cell Biochem. 420(1-2):29-42. ISI
Impact Factor 2.613.
Nadimi, M., Rahgozar, S., Moafi, A., Tavasoli, M., Mesrian Tanha, H.Evaluation of rs6252760 [GT]
Single Nucleotide Polymorphism Located in BAALC Gene in children with acute leukemia using
mismatch PCR-RFLP.(2016). Cancer Genetics. 209(7-8):348-53. ISI Impact Factor 2.975.
M Dabaghi, S Rahgozar, J Moshtaghian, A Moafi, M Abedi, M Pourabutaleb (2016). SORCIN gene
overexpression in childhood acute lymphoblastic leukemia and its impact on multidrug resistance.
Genetic Testing and Molecular Biomarkers. 20(9):516-21. ISI Impact Factor 1.297.
Moafi A, Vallian R, Vallian S, Rahgozar S, Torfenajad M, Moafi H. The pros and cons of the fourth
revision of thalassaemia screening programme in Iran.(2016). J Med Screen. Epub ahead of print. ISI
Impact Factor 3.099.
Hamzeh Mesrian Tanha, Marjan Mojtabavi Naeini, Soheila Rahgozar, Alireza Moafi, Mohammad
Amin Honardoost. Integrative computational in-depth analysis of dysregulated miRNA-mRNA
interactions in drug resistant pediatric acute lymphoblastic leukemia cells: an attempt to obtain new
potential gene-miRNA pathways involved in response to treatment (2016). Tumor Biology.
37(6):7861-72. ISI Impact Factor 3.611.
Soheila Rahgozar, Tayebeh Amirian, Miao Qi, Zahra Shahshahan, Mansureh Entezar-E-Ghaem,
Hatav Ghasemi Tehrani, Mehran Miroliaei, Steven A. Krilis , Bill Giannakopoulos (2015). Improved
Assay for Quantifying a Redox Form of Angiotensinogen as a Biomarker for Pre-Eclampsia: A Case-
Control Study. PLOS one. 10(8):e0135905. . ISI Impact Factor 3.534.
Zahra Azizi, Soheila Rahgozar, Mohammad Dabaghi, Alireza Moafi, Motahareh Nadimi (2015).
mRNA overexpression of BAALC gene; a novel prognostic factor for pediatric acute lymphoblastic
leukemia. Biomedical Reports. 3(3):371-374.
H Mesrian Tanha, M Mojtabavi Naeini, S Rahgozar, S.M.M Rasa, S. Vallian (2015). Modified tetra-
primer ARMS PCR as a single-nucleotide polymorphism genotyping tool. Genetic Testing and
Molecular Biomarkers 19 (3): 156-61. ISI Impact Factor 1.464
N. Aberuyi, S. Rahgozar, A. Moafi (2014). A literature – based approach to the role of ATP-binding
cassette transporter A2 in childhood acute lymphoblastic leukemia multidrug resistance. Iranian
Journal of Pediatric Hematology Oncology.4(3):118-126
Zohreh Khosravi Dehaghi,Narges Aberuyi,Marjan Abedi, Soheila Rahgozar (2014). The Role of
MDR1 in Immune System and Neurodegenerative Disorders (Persian with English abstract).
Journal of Mazandaran University of MedicalSciences; 24(113): 12-26
Soheila Rahgozar, Alireza Moafi, Marjan Abedi, Mansureh Entezar-e-ghaem, Jamal Moshtaghian,
Kamran Ghaedi, Abolg-hasem Esmaeili, and Fatemeh Montazeri (2014). mRNA expression profile of
multidrug-resistant genes in acute lymphoblastic leukemia of children a prognostic value for ABCA3
and ABCA2. Cancer Biology & Therapy 15:1, 35–41. ISI Impact Factor 3.63. CI 14.
M A Honardoost, H Mesrian Tanha, M Etemadifar, S Rahgozar, M Salehi, KGhaedi (2013). The Role
of miRNAs in Multiple sclerosis. (Persian with English abstract). Genetics in the 3rd millennium
12(1):3448-3469.
Amirian T., Rahgozar S., Shahshahan Z. preeclampsia in a cellular and molecular view (2013).
Journal of Isfahan Medical School. (Persian with English abstract). 31(234): 565-580
Entezar-e-Ghaem , Rahgozar S, Moafi AR ,Moshtaghian J, Esmaeli A, Abedi M, Montazeri F (2013)
Evaluation of mRNA expression profile of abcg2/bcrp in childhood acute lymphoblastic leukemia .
(Persian with English abstract). Journal of Shahid Sadoughi University of Medical Sciences 21(5):575-
586
Mansoureh Entezar-e-Ghaem, Soheila Rahgozar, Ali Reza Moafi (2013) . The methods to overcome
ATP-binding cassett transporters-mediated multi-drug resistance. (Persian with English abstract).
Journal of Isfahan Medical School, 30(213): 1-16
Hamzeh MesrianTanha, Mohammad Amin Honardoost, Soheila Rahgozar , Kamran Ghaedi (2013)
Evaluation of Oncogenic Pathways in T-ALL; New Applications in Treatment. (Persian with English
abstract). Genetics in the 3rd Millennium 11(2): 3100-3111.
M. Abedi, S. Rahgozar, A.R. Moafi, K. Ghaedi, S.J. Moshtaghian, M. Entezar-e-Ghaem, F. Montazeri.
(2013) Prognostic importance of MDR1 gene transcripts in childhood ALL. (Persian with English
abstract). The Scientific Journal of Iranian Blood Transfusion Organization 10(4): 326-334.
M. Abedi, S. Rahgozar. P-glycoprotein 170 (2013); Its clinical importance and pathophysiological role
in cancer. (Persian with English abstract). Journal of Isfahan Medical School 228(2):274-293.
S. Rahgozar, M. Entezar-e-Ghaem, M. Abedi, F. Montazeri. Application of stem cells for the
treatment of hemoglobinopathies. (Persian with English abstract) .The Scientific Journal of Iranian
Blood Transfusion Organization. 2012; Stem Cell Supp. 9(3): 258-272.
Abedi M, Ahmadi A, Rahgozar S (2012).Introduction to the corneal stem cells and other cellular
sources in the corneal disorder treatment. (Persian with English abstract). Bina Journal. 18(2): 208-
221.
Soheila Rahgozar (2012) . Revisiting Beta 2 glycoprotein I, the major autoantigen in the
antiphospholipid syndrome. Iranian Journal of Immunology. 9(2) 73-85. ISI Impact Factor 0.707.CI
10
Rahgozar S, Entezare Ghaem M, Abedi M, Montazeri F (2012). The clinical use of stem cells in
hemoglobinopathies. (Persian with English abstract). The Scientific Journal of Iranian Blood
Transfusion Organization. 9(3):258-272.
Alireza Moafi*, Soheila Rahgozar (*equal contribution to the manuscript), Majid Ghias, Maryam
Hajian, Najmeh Ghorbani, Akbar Hassanzadeh (2012). The Effects of Supplemental Iron on
Educational Achievements of Students with “Iron Deficiency without Anemia”: A Randomized,
Double-Blind, Placebo-Controlled Trial HealthMed Journal. 6(6):2047-2051. ISI Impact Factor
0.33.
Mohammadi S, Rahgozar S, Ghaedi K (2011). A review on the structure and function of mico RNAs;
their impact on cancer. (Persian with English abstract). Genetics in the 3rd millennium, 9(3): 2489-
2498.
Fatemeh Montazeri, Soheila Rahgozar, Kamran Ghaedi (2011). Apoptosis and Cytosolic Organelles
(Persian with English abstract). Genetics in the 3rd millennium, 9(1):2300-12.
Esmat Mohammadi, Kamran Ghaedi, Abolghasem Esmaeili, Soheila Rahgozar (2011). Molecular
mechanism of peroxisome proliferator activated receptors during inflammation (Persian with English
abstract). Genetics in the 3rd millennium,9(2):2410-20.
Moafi A1, Rahgozar S1 (1equal contribution to the manuscript), Ghias M, Vahdat ahar E, Borumand
A ,Sabbaghi A, Sameti A, Hashemi M (2011). A Study on Body Mass Index, Blood Pressure, and Red
Blood Cell Indices in New Entering Students of the University of Isfahan. International Journal of
Preventive Medicine, 2(4):280-5.
Rahgozar S, Pakravan G, Ghaedi K (2010). Cellular adhesions and signaling pathways in platelets
(Persian with English abstract). The Scientific Journal of Iranian Blood Transfusion Organization,
8(1):60-73.
Fatemeh Montazeri, Soheila Rahgozar, Kamran Ghaedi (2010). Molecules and signaling pathways in
transendothelial migration of leukocytes (Persian with English abstract). Genetics in the 3rd
millennium, 8(2):2043-53.
Alireza Moafi, Sadeg Valian, Zahra Nikyar, Mehrdad Zeinalian, Maryam Momenzadeh, Soheila Rahgozar
(2010). Prevalence of minor β-thalassemia based on RBC indices among final suspected individuals in
premarital screening program referred to genetic laboratories. International Journal of Hematology
Oncology and Stem Cell Research (IJHOSCR), 1(11):23-7.
F.H. Passam1, S. Rahgozar1(1equal contribution to the manuscript), M. Qi, M.J Raftery, J.W.H.
Wong, K. Tanaka, R. Gemmell, B. Giannakopoulos, J.C. Qi, Y.Ioannou, J.Y. Zhang, W.E. Hughes,
P.J. Hogg, and S.A. Krilis (2010). Redox control of β2GPI-von Willebrand factor interaction by
thioredoxin-1. Journal of thrombosis and haemostasis, 8(8):1754-62. ISI Impact Factor 6.291, CI 37
Freda H Passam1, Soheila Rahgozar1(1equal contribution to the manuscript), Miao QI, Mark J
Raftery, Jason WH Wong, Kumiko Tanaka, Yiannis Ioannou, Jingyun Zhang, Rosalie T Gemmell,
Jian Cheng Qi, Bill Giannakopoulos, William E. Hughes, Philip J. Hogg, and Steven A. Krilis. (2010).
Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Blood, 116(11):1995-7. ISI Impact
Factor 10.558, CI 40
Yiannis Ioannou, Jingyun Zhang, Freda H Passam, Soheila Rahgozar, Jian Cheng Qi, Bill
Giannakopoulos, Miao Qi, Pei Yu, Demin M. Yu, Philip J. Hogg, Steven A. Krilis. (2010). Naturally
occurring free thiols within β2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial
cells, and regulation of oxidative stress–induced cell injury. Blood, 116(11):1961-70. ISI Impact
Factor 10.896, CI 63
Rahgozar S, Giannakopoulos B, Yan X, Wei J, Qi JC, Gemmell R, Krilis S.A (2008). Beta 2
Glycoprotein I protects thrombin from inhibition by heparin cofactor II: potentiation of this effect by
anti-β2 glycoprotein I autoantibodies. Arthritis & Rheumatism, 58 (4):1146-1155. ISI Impact Factor
7.677, CI 23
Enattah NS, Trudeau A, Pimenoff V, Maiuri L, Auricchio S, Greco L, Rossi M, Lentze M, Seo JK,
Rahgozar S, Khalil I, Alifrangis M, Natah S, Groop L, Shaat N, Kozlov A, Verschubskaya G, Comas
D, Bulayeva K, Mehdi SQ, Terwilliger JD, Sahi T, Savilahti E, Perola M, Sajantila A, Jarvela I,
Peltonen L (2007). Evidence of still-ongoing convergence evolution of the lactase persistence T-13910
alleles in humans. Am J Hum Genet. 81(3):615-25. ISI Impact Factor 11.092, CI 111
Rahgozar S, Yang Q, Giannakopoulos B, Yan X, Miyakis S, Krilis S.A (2007). β2 Glycoprotein I
binds thrombin via exosite I and exosite II; anti- β2GPI Antibodies potentiate the inhibitory effect of
β2GPI on thrombin mediated FXIa generation. Arthritis & Rheumatism. 56(2): 605-613. ISI Impact
Factor 7.677, CI 29
Giannakopoulos B, Passam P, Rahzogar S, Krilis S.A (2007). Current concepts on the pathogenesis of
the antiphospholipid syndrome. Blood. 109: 422-430. ISI Impact Factor 10.896, CI 233
Rahgozar S, Yavari FM (2005). ABO discrepancies: prevalence and related factors in Iranian blood
donors. (Persian with English abstract). The Scientific Journal of Iranian Blood Transfusion
Organization. 2(6):99-107.
Rahgozar S, Moafi AR, Yavari FM, Hourfar H. (2005) Alloantibody detection in major beta
thalassaemic patients transfused within less-than-20-day intervals (Persian with English abstract). The
Scientific Journal of Iranian Blood Transfusion Organization. 1(2):1-9
Moafi AR, Rahgozar S, Hourfar H, Shirani B (summer 2004). Evaluation of new cases of thalassemia
major following minor thalassemia screening program in Isfahan (Persian with English abstract).
Journal of Isfahan Medical School. 22(73):11-14.
Moafi AR, Rahgozar S, Pourfathollah AA, Hariri MM (2004) Blood group antigens frequency: a
comparative study in intermediate thalassemics versus healthy people in Isfahan. (Persian with English
abstract) The Scientific Journal of Iranian Blood Transfusion Organization ,2(3):23-29
Rahgozar S, Salehi M, Pourfathollah AA, Moafi AR, Fatehi far MR, Jarvela I (2004) A study of the
C/T -13910 variant in association with primary hypolactasia in the village population samples of Central
Iran (Persian with English abstract). Hakim Scientific Research Journal. 7(1): 57-62
Pourfathollah AA, Rahgozar S, Moafi AR (2003) The importance of precise measurment of HbF in
the differential diagnosis of sickle cell anemia from sickle beta thalassemia (Persian with English
abstract). Journal of Medical Council of I.R.I. 21(1):51-54
Rahgozar S (2003) SARS (Persian) (Review article). Journal of Blood 30:2-8
Rahgozar S (2002) Patophysiology of platelet destruction in immune (idiopathic) thrombocytopenic
purpura (Persian) (Review article). Journal of Blood 28:29-32
Rahgozar S, Pourfathollah AA, Moafi AR (2000) The incidence and determination of sickle cell’s
haplotype in Jar region of Isfahan province (Persian with English abstract). J Pejouhandeh (Med J
Sahid Beheshti University) 4 (4): 409-414 (Abstract: 12)
Rahgozar S, Poorfathollah AA, Moafi AR, Old JM (2000) Beta S gene in central Iran is in linkage
disequilibrium with Indian – Arab haplotype. Am. J. Hematol 65(3): 192-195. ISI Impact Factor
1.949, CI 22
Rahgozar S, Pourfathollah AA, Moafi AR (2000) Sickle cell in Central of Iran and the ways of
preventing it’s syndromes (Persian with English abstract). Modarres Journal of Medical Science 2(2):
57-62 (Abstract: 126)
Rahgozar S (1998) G hepatitis (Persian) (Review article). Thalassemia 4: 6-8
Rahgozar S (1998) Factor V Leiden (Persian) (Review article). Thalassemia 5: 1-4
Book publications
Rahgozar S, Abedi M, Khosravi Dehaghi Z, Aberuyi N (2017) MicroRNAs; Identification and
application (Persian). University of Isfahan, Isfahan, Iran. Selected as the best book of 2017 by the
University of Isfahan.
Rahgozar S, Aberuyi N, Moafi H (2016) ATP-binding cassette subfamily A member 2 , in Choi S
(editor) Encyclopedia of Signaling Molecules. Springer Science and Business Media LLC.
Rahgozar S, Ghaedi K (2014) Stem cells and tissue regeneration (Persian). University of Isfahan,
Isfahan, Iran. Selected as the best book of 2 years by the Ministry of Culture and Islamic Guidance.
Rahgozar S, Poorfathollah AA (2003) Education, recruitment, selection and protection of blood
donors (Persian). Boshra, Tehran, Iran.
Symposia
International
Shahrzad Pouyanrad, Soheila Rahgozar (2017). Targeting long non-coding RNAs to enhance
therapy efficiency and overcome multidrug resistance in hematological malignancies. The 2nd
international congress on hematological disorders (new challenges in diagnosis and treatment) ,
Shiraz, Iran. P159. Poster presentation
Farzaneh ohadi, Soheila Rahgozar (2017).The Role of Stem Cell Differentiation Factors in
Leukemogenesis and Their Importance in Diagnosis and Treatment of Acute Lymphoid Leukemia,
The 2nd international congress on hematological disorders (new challenges in diagnosis and
treatment) . shiraz, Iran.P101.poster presentation
Somayeh Rahimi, Soheila Rahgozar (2016). Ginger, an old pleasant spice, a new potential drug. The
2nd international Nastaran cancer symposium, Mashhad, Iran.P61. Poster presentation
Marjan Abedi, Narges Aberui, Somaye Najafi Dorcheh, Soheila Rahgozar (2016). A comparison of
leukemia incidence in Iran, France and Germany and evaluation of its etiological causes and
treatment. The 1st trilateral conference of Transfer of knowledge among Iran, France and Germany,
Isfahan, Iran. P30. Oral presentation
M. Mohammadi, S. Rahgozar (2015). Calculation of the minimal lethal dose of methotrexate on
CCRF-CEM lymphoblastic cells for use in drug combinations. International congress on blood,
diseases and clinical administrations, Yasuj , Iran. p.63. Oral presentation
E. Pouraboutaleb, S. Rahgozar, A. Moafi (2015). Drug resistance and multidrug resistance in blood
cancer; differences and similarities. The international congress in Challenges in Pediatric Hematology
& Oncology, Tehran , Iran. p.123.Poser presentation
M. Mohammadi, S. Rahgozar (2015). The effect of cinnamon on cancer treatment.The international
congress in Challenges in Pediatric Hematology & Oncology, Tehran , Iran. p.125.Poser presentation
Z. Khosravi Dehaghi, S. Rahgozar (2013). "Effects of ABC Transporters Expression on neural stem
cells". The 2nd International neuroscience Congress. p.379..Poster presentation .
N. Aberuyi, Z. Khosravi, S. Rahgozar (2013). Roles of ABC Blood-Brain Barrier transporters in
Multiple Sclerosis. The 10th International Iranian MS Congress and 1st International Iranian Congress
of Devic syndrome,. Poster presentation
Dabaghi M, Rahgozar S, Moshtaghian J, Abedi M (2013). cDNA synthesis of the RNA of SRI gene
in leukemia patient samples. The 1st Tabriz International Life Science Conference and the 12th Iran
Biophysical Chemistry Conference, Tabtiz University of Medical Sciences. .p.348.Poster presentation
Soheila Rahgozar, Freda Passam, Bill Giannakopoluos, Miao Qi, Jian Chen Qi, Steven Krilis (2011).
The interaction of Beta 2 Glycoprotein I with vWF is thiol dependent and promotes the binding of
GPIbα to vWF: Implications to the redox regulation of platelet adhesion. The 4th international
congress of Biochemistry and Molecular Biology, Mashhad, Iran, A-10-261-1, Poster presentation
Soheila Rahgozar, Freda Passam, Yiannis Ioannou, Jing Yun, Phil Hogg, Jason Wong, Mark
Raftery, Steven Krilis (26-27 May 2010) Is beta 2 glycoprotein I involvement in redox reactions a key
to determine its physiological function? The 3rd Iranian congress of proteomics, Tehran, Iran, P-19,
Poster presentation
Ioannou Y, Zhang JY, Passam F, Rahgozar S, QI J, Giannakopoluos B, QI M, Yu P, YU D, Hogg P,
Krilis S. (13-16 April 2010) Naturally occurring free thiols within β2GPI in vivo: Functional
implications in the regulation of oxidative stress induced endothelial cell injury. 13th International
Congress on Antiphospholipid Antibodies, Galveston, Texas, United States, A021, Oral presentation.
Ioannou Y, Zhang JY, Passam F, Rahgozar S, Qi J, Giannakopoulos B, Qi M, Yu P, Yu D, Hogg P,
Krilis. (April 2010) Human endothelial cells secrete oxidoreductases on the cell surface and can both
nitrosylate and modulate the redox state of Beta 2-glycoprotein I. 13th International Congress on
Antiphospholipid Antibodies, Galveston, Texas, United States , A023, Poster presentation
Freda Passam, Soheila Rahgozar, Bill Giannakopoulos, Miao Qi, Kumiko Tanaka, Phil Hogg, Jason
Wong, Mark Raftery, Steven Krilis (13-16 April 2010) Beta 2 glycoprotein I is a substrate of thiol
oxidoreductases, 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas,
United States, A025, Poster presentation
Giannakopoulos B, Rahgozar S, Passam F, Gemmell R, Qi M, Qi JC, Krilis SA (April 2010)
Reduction of beta 2-glycoprotein I by thioredoxin-1 promotes binding to von Willebrand factor, 13th
International Congress on Antiphospholipid Antibodies, Galveston, Texas, United States , A026,
Poster presentation
Rahgozar S, Giannakopoulos B, Yan X, Qi J, Gemmell R, Krilis SA. (6-12 July 2007) Beta 2
Glycoprotein I protects thrombin from inhibition by heparin cofactor II: loss of activity by
proteolytically clipped Beta 2 Glycoprotein I. XXIst Congress of the International Society of
Thrombosis and Haemostasis, Geneva, Switzerland, O-S-008, Oral presentation.
Enattah NS, Trudeau A, Pimenoff V, Seo JK, Rahgozar S, Comas D, Mehdi SQ, Sahi T, Savilahti E,
Perola M, Sajantila A, Jarvela I, Peltonen L (26-30 October 2004).The introduction of the lactase
persistence mutation into global population. 54th Annual Meeting of the American Society Human
Genetics, Toronto, Canada, Program Number 151
Rahgozar S, Pourfathollah AA, Moafi AR (2003) How to prevent sickle cell syndromes in areas
where thallassemia is common? The 9th International Conference on Thalassemia an
hemoglobinopathies, Palermo, Italy, 026. Oral presentation
National
E. Ghodoussi Shamsabadi, S. Rahgozar ( October 2016).Application of microRNAs in diagnosis and
treatment of cancer. 3rd national congress of Biology and National Sciences of Iran. p1-9. Poster
presentation
Somayeh Rahimi BabaSheikhali, Soheila Rahgozar (18-19 May 2016), Selective cytotoxic effect of
ginger extract on CCRF-CEM tumor cell line in comparison with normal peripheral blood
mononuclear cells. 5th National congress on medicinal plants. Isfahan, Iran. Abstracts sited at Iranian
Journal of Pharmaceutical Research (ISI impact factor 1.35). p515. Poster presentation M. Abedi, S Rahgozar (March 2016). The best animal model in cancer research: Genetically
engineered mouse or Xenograft? 1st National congress on animal models in experimental medicinal
researches. Shiraz, Iran. p 144. Poster presentation
E. Ghodoussi Shamsabadi, S. Rahgozar (Feb 2016). Predicting the effect of miR-140 on drug
resistance in acute lymphoblastic leukemia. 2nd national conference on molecular medicine in
diagnosis and treatment of diseases, Iran, Tehran. p154. Poster presentation
E. Ghodoussi Shamsabadi, S. Rahgozar (2015). The role of miR-324 in blood cancer treatment
unresponsiveness based on Bioinformatics. 1st national conference on biotechnology achievements in
Iran Biology, Babolsar, Iran. p52. Poser presentation
Z. Azizi, S. Rahgozar, M. Dabaghi, (2014). BAALC gene and acute leukemia, is there any
association?. 18th National and 6th International Congress of Biology, Iran. p. 371. Poser
presentation
Z. Azizi, S. Rahgozar (2014). A study on hematopoietic and leukemic stem cells niches and their
association with drug resistance. 1th National Congress of Biology and Natural Sciences, Iran. p.5.
Oral presentation
Z. Azizi, S. Rahgozar (2014). The use of nanoparticles in order to overcome drug resistance . 1th
National Congress of Biology and Natural Sciences, Iran. p.24. Poser presentation
N. Aberuyi, S. Rahgozar, A. Moafi (2014). Prediction of involved microRNAs in modulation of
ABCA2 transporter in order to confront multi drug resistance in acute lymphoblastic leukemia using
bioinformatic methods. The 8th Congress of Iranian Pediatric Hematology & Oncology Society, p. 85.
Poser presentation..
Z. Khosravi Dehaghi, S. Rahgozar, A. Moafi (2014). "MicroRNA targeting ABCA3, a therapeutic
approach for childhood acute lymphoblastic leukemia". The 8th Congress of Iranian pediatric
hematology & oncology society, p.53.Oral presentation
Z. Khosravi Dehaghi, S. Rahgozar (2013). The role of ABC transporters in cancer stem cells. The 1th
National Bioscience Congress,. p.56. Poster presentation.
Z. Khosravi Dehaghi, S. Rahgozar (2013). How to overcome Glucocorticoid resistance in childhood
acute lymphoblastic leukemia? 3rd National Congress of hematology, p.21. Poster presentation
N. Aberuyi, Z. Khosravi Dehaghi, S. Rahgozar (2013). "Roles of ABC Blood-Brain Barrier
transporters in Multiple Sclerosis". The 10th International Iranian MS Congress, p.144. Poster
presentation
N. Aberuyi, S. Rahgozar, M. Abedi (2013). New approach to multi-drug resistance in acute
lymphoblastic leukemia. The 3th National Congress of Hematology, p. 51. Poser presentation
N. Aberuyi, S. Rahgozar, A. Moafi (2013). Roles of ABCA2 in Alzheimer’s disease. The 2nd Basic
and Clinical Neuroscience Congress 2013, p. 235. Poser presentation.
N. Aberuyi, S. Rahgozar. Role of miRNAs in Acute Lymphoblastic leukemia. The 1th National
Bioscience Congress, Poser presentation
H. Mesrian Tanha, S. Valian, S. Rahgozar (2013). Tetra-primer ARMS PCR for detection of A934C
ABCC4 genotype in children with Acute Lymphoblastic Leukemia. 1st Tabriz International Life
Science Conference and 12th Iran Biophysical Chemistry Conference. p.399.Poster presentation.
Dabaghi M, Rahgozar S, Moshtaghian J, Abedi M (November 19-21, 2013). The effect of Sorcin on
Apoptosis in Leukemia. The 3th National Congress of Heamatology, p. 37 ; Yazd-Iran. Poster
presentation.
Amirian T., Rahgozar S. A novel diagnostic approach for disease; selective detection of free thiols
(April 16-19, 2013). 5th International congress of biochemistry and molecular biology. Yazd-Iran, p-
176. Poster presentation.
M. Entezar-e-Ghaem, Soheila Rahgozar, A.R. Moafi. Evaluation of ABCC3/MRP3 Expression in
Childhood Acute Lymphoblastic Leukemia. (September 3-6,2012) The 13th Iranian Pharmaceutical
Sciences Congress;. Isfahan-Iran. Research in Pharmaceutical Sciences, 2012;7(5). Poster
presentation.
M. Abedi, S. Rahgozar, A.R. Moafi, J. Moshtaghian, K. Ghaedi, A. Esmaeli, M. Entezar-e-Ghaem, F.
Montazeri (September 3-6, 2012). MDR1 Gene Expression in Acute Lymphoblastic Leukemia;
Implications in Pharmacokinetics and Relapse. The 13th Iranian Pharmaceutical Sciences Congress;
Isfahan-Iran. Research in Pharmaceutical Sciences, 2012;7(5).Poster presentation
Rahgozar S, Krilis SA. (2012) New insights into the molecular mechanisms of coagulation. The
Second National Congress of Hematology. Yazd, Iran. Iranian Journal of Pediatric Hematology &
Oncology. 2(2), Suppl 1:76. Poster presentation.
Zinodini N, Rahgozar S. (2012) Molecular mechanisms of tumor angiogenesis. The Second National
Congress of Hematology. Yazd, Iran. Iranian Journal of Pediatric Hematology & Oncology. 2(2),
Suppl 1:88. Poster presentation.
Abedi M, Rahgozar S. (2012) Iron deprivation effects on leukemic cells. The Second National
Congress of Hematology. Yazd, Iran.. Iranian Journal of Pediatric Hematology & Oncology. 2(2),
Suppl 1:57. Oral presentation
Entezare Ghaem M, Rahgozar S, Moafi A, Moshtaghian J, Ghaedi K, Abedi M, Montazeri M.
(2012) Evaluation of ABCG2/BCRP Expression in Childhood Acute Lymphoblastic Leukemia.
Second National Congress of Hematology. Yazd, Iran.. Iranian Journal of Pediatric Hematology &
Oncology. 2(2), Suppl 1:51. Oral presentation
Abedi M, Rahgozar S. (2011) Molecular mechanisms of drug resistance in acute lymphoblastic
leukemia. 6th Annual Congress of Iranian Blood and Pediatric Cancer Society, Ahvaz, Iran, P-74. Poster presentation.
A Ahmadi, M Abedi, S Rahgozar (2011). Genetic Disorders of corneal epithelium and their new
therapeutic Methods. The Second National Congress of Iran Medical Genetics, Tehran, Iran., p-231
Poster presentation
Rahgozar S. (December 2009) Thrombosis and autoantibodies in antiphospholipid syndrome,
Research Week Symposium, University of Isfahan, Iran, Oral presentation.
Rahgozar S, Giannakopoulos B, Yan X, Qi J, Gemmell R, Krilis SA.(2008) The antiphospholipid
syndrome autoantigen, beta 2 glycoprotien I (beta 2GPI), regulates thrombin inactivation by heparin
cofactor II: auto-antibodies against beta 2GPI may promote thrombin activity, SGH Medical
Symposium, Sydney, Australia, Oral presentation.
Rahgozar S, Yang Q, Giannakopoulos B, Yan XK, Miyakis S, Krilis S.A. (2006), Beta2-
Glycoprotein I Binds Thrombin via Exosite I and Exosite II, SGH Medical Symposium, Sydney,
Australia, Poster presentation.
Rahgozar S, Pourfathollah AA, Moafi AR (2000) Haplotyping sickle cell gene in Persian populations
living in some villages around Esfahan . The First National Congress of Biotechnology, Tehran, Iran.,
1:p508-514. Oral presentation
Moafi AR, Pourfathollah AA, Rahgozar S (1999) The comparison between cascade screening and
village screening in sickle cell controlling programs. The Twenty First National Congress of The
Current Problems in Pediatric Medicine, Esfahan, Iran. p789-791. Oral presentation
Activities as reviewer for journals submitted to
1. Leukemia and lymphoma (IF 2.89)
2. International journal of fertility and sterility (IF 0.98)
3. Genetics in the third millennium
4. Scientific Journal of Iranian Blood Transfusion Organization
5. Genetic testing and molecular biomarkers (IF 1.29)
6. Mediterranean Journal of Hematology and Infectious Diseases
Theses & Dissertations Supervised
1. Gene expression profile of MDR1 in Childhood acute lymphoblastic leukemia - 20 OCT
2012
2. Transcript and protein expression profiles of the multi-drug resistance-related gene,
ABCA2, in lymphoblasts of the children with acute lymphoblastic leukemia - 20 OCT
2012
3. Measurement of reduced angiotensinogen in preeclamptic patients and evaluation of its
diagnostic value – 3 NOV 2013
4. Evaluation of C934A ABCC4gene Single Nucleotide polymorphism in children with
Acute Lymphoblastic- Leukemia – 21th JAN 2014
5. A study on Sorcin gene expression in patients with acute lymphoblastic leukemia – 21
JAN 2014
6. A study on BAALC gene expression in lymphoid cancer stem cells and its relation with
neural cells – 14 FEB 2014
7. A comparative study of ABCA3 gene expression at the mRNA and protein levels,
associated with multi-drug resistance in childhood acute lymphoblastic leukemia - 21 SEP
2014
8. Transcript and protein expression profiles of the multi-drug resistance-related gene,
ABCA2, in lymphoblasts of the children with acute lymphoblastic leukemia – 21 SEP
2014
9. Evaluation of G424T Single Nucleotide Polymorphism Located in BAALC Gene in
Children with Acute Leukemia – 11 OCT 2014
10. Establishment of drug-resistance in CCRF-CEM cell line and the study of ABCA2 and
ABCA3 mRNA expression profiles in the CCRF-CEM subline – 19 JAN 2016
11. The effect of cinnamon extract on acute lymphoblastic leukemia - 19 JAN 2016
12. Evaluating the effect of methotrexate and ginger extract combination on the viability of the
lymphoblastic cell line, CCRF-CEM, and its relation to the ABCA3 mRNA expression
levels – 18 DEC 2016
13. Analysis of microRNA expression profiles in multi-drug resistance of children with acute
lymphoblastic leukemia - 18 DEC 2016
14. Investigation and evaluation of miRNA expression profiles associated with multidrug
resistance in pediatric acute lymphoblastic leukemia – 23 SEP 2017
15. Recognition and understanding of miRNAs regulating multidrug resistance in pediatric
acute lymphoblastic leukemia – 15 OCT 2017
16. Assessment of the fatty acid synthase (FAS) mRNA profile in children with acute
lymphoblastic leukemia and evaluating the effect of ginger extract on FAS – 10 FEB 2018
Patents
1. A diagnostic kit for evaluating the serum levels of reduced angiotensinogen, Patent
granted from: State Organization of Deeds and Properties, Intellectual Property Center
(3 Jan2011), Patent number: 1393/10/13-84673
Workshop, seminar & conferences organized/conducted
2011 Lessons in specific Serology tests, Iranian Blood Transfusion Organization –
Isfahan Centre, Jun 13th –7 hours
2012 Pre-transfusion testing, Iranian Blood Transfusion Organization – Isfahan
Centre, Jan 26th - 7 hours
2013 How to use “End note program” for writing papers in the field of Biology,
University of Isfahan-Faculty of Science, Feb 26th – 4 hours
2013 “End note program” for improving and management of researches with
Different topics in the area of Biology, University of Isfahan-Faculty of
Science, Nov 16th & 17th – 8 hours
2013 SNPs and predicting their function using bioinformatics, University of Isfahan-
Faculty of Science, May 5th & 6th – 12 hours
2014 SDS-PAGE and Western blotting, University of Isfahan-Faculty of Science,
Nov 20th & 21st - 12 hours
Courses Taught
a) Undergraduate Level
1. Cell Biology
2. Physiology
3. Molecular Biology
b) Graduate Level
M.Sc. Level:
1. Advanced Molecular Biology
2. Immunology
3. Developmental Biology
4. Advanced Cell Biology (1)
5. Advanced Cell Biology (2)
6. Advanced Techniques in Cell and Molecular Biology
7. Advanced Techniques in Biochemistry and Biophysics
8. Physiology of Blood
9. Stem cells
10. Cell cycle
Ph.D. Level:
1. Advanced Cell Biology
2. Stem Cells
3. Molecular and Cellular Cancer Biology
4. Developmental Immunology
Research Projects
National Level:
1- 2015-2018 : Evaluation of the effect of cinnamon, green tea and ginger extracts on the viability
of leukemic cells (supported by Vice-presidency for Science and Technology, grant
11/67042;SR)
University Level:
1- 2013-2015: Comparative analysis of ABCA2 and ABCA3 genes expressions on mRNA and
protein levels in children with acute lymphoblastic leukemia (Supported by Isfahan University
of Medical Sciences, (grant 192018; S.R. & A.M.)
2- 2011-2013: Measuring reduced angiotensinogen by ELISA and evaluation of this assay as a
novel diagnostic test for pre-eclampsia (Supported by University of Isfahan, grant 90/80169;
S.R.)
3- 2010-2012: Identification of the mRNA expression profile of multidrug resistance genes in
acute lymphoblastic leukemia (ALL) in order to generate a diagnostic kit for ALL treatment
non-responders. (Supported by University of Isfahan, grant89/93264; S.R.)
Inter-university Level:
1- 2010-2011: Evaluation of the effect of supplemental iron on educational achievements in
“non anemic iron deficient” girl students at the Faculty of Science, University of Isfahan
(Supported by Isfahan University of Medical Sciences, grant 189073 ; S.R. & A.M.)
2- 2009-2010: Evaluation of Iron deficiency at university entrance and its effect on
educational achievement in University of Isfahan and Isfahan University of Medical
Sciences (Supported by Isfahan University of Medical Sciences (grant 188162; S.R. &
A.M.)
Department/University Administration
2013-2015: Member of the committee of Research, Department of Biology, Faculty of Science,
University of Isfahan
2015-2017: Vice president of Research, Department of Biology, Faculty of Science, University
of Isfahan
Membership 1- 2010-2015: Member of the Committee of Stem Cells, University of Isfahan
2- 2013-2015: Member of the Research center of Cellular and Molecular Immunology
3- 2011-2014: Member of the Research Committee of Iranian Blood Transfusion Organization-
Isfahan Centre
4- 2009-2010: Member of the Institute of Practical Biotechnology, University of Isfahan