Research Institute for Research Institute for

Medicinal Plants and HerbsMedicinal Plants and Herbs

FAO Expert Roundtable BUDAPEST / Budakalasz 2012.04.2-5FAO Expert Roundtable BUDAPEST / Budakalasz 2012.04.2-5

Jozsef Peter PALLOS CEO Jozsef Peter PALLOS CEO

RIMPH - PannonPharma RIMPH - PannonPharma

RIMPH-PannonPharma RIMPH-PannonPharma

RIMPH member of the group of pharma companies:RIMPH member of the group of pharma companies: PannonPharma Pharmaceuticals Ltd PannonPharma Pharmaceuticals Ltd

R+D, mid scale Manufacturing of solid dosage drugsR+D, mid scale Manufacturing of solid dosage drugs Trigon Biotech Ltd - Trigon Biotech Ltd - Clongen – Biopharma - LtdClongen – Biopharma - Ltd RIMPH - GYNKI vertically integrated company for RIMPH - GYNKI vertically integrated company for

medicinal plants to herbal medicinesmedicinal plants to herbal medicines

>100 years of tradition>100 years of tradition 1884 1884 Páter BélaPáter Béla the founder of medicinal plant research Kolozsvar the founder of medicinal plant research Kolozsvar

1915 1915 Irk KárolyIrk Károly established the HR Establishment for Medicinal Plants established the HR Establishment for Medicinal Plants

1924 Kabay János started the poppy opiates extraction R+D1924 Kabay János started the poppy opiates extraction R+D

1925 Augustin Béla1925 Augustin Béla developped the medicinal plant improvement, and qualification developped the medicinal plant improvement, and qualification system, as the model of the european medicinal plant regulations1951 system, as the model of the european medicinal plant regulations1951

1934 Békésy Miklós started thef claviceps purpurea R+D activities1934 Békésy Miklós started thef claviceps purpurea R+D activities

1951 Institute for mMedicinal Plants - GyógynövényKutató Intézet1951 Institute for mMedicinal Plants - GyógynövényKutató Intézet 1957-től 1957-től Tétényi PéterTétényi Péter started new varieties, improvents > 50 officially tested end started new varieties, improvents > 50 officially tested end

approved varietiesapproved varieties

1969 Budakalasz site opening 1969 Budakalasz site opening

1970 official medicinal plant state control activities, release of batches (plants, drugs, 1970 official medicinal plant state control activities, release of batches (plants, drugs, extracts etc) for medicinal useextracts etc) for medicinal use

1982 joint venture company of Hungarian (big )pharmaceutical companies 1982 joint venture company of Hungarian (big )pharmaceutical companies

2003 Nature Conservation Area of Chemotaxonomy Botanical Garden2003 Nature Conservation Area of Chemotaxonomy Botanical Garden

Janos Kabay (1896–1936) Invented the opium free world

Developped theExtraction process of alkaloids from poppy straw

- first patent y1925extraction from green plant

- final patent y1931 extraction from dried poppy capsule

- first pre INCB audit ever y1935 League of Nations -UN predecessor

World class researchers of RIMPHWorld class researchers of RIMPH

Augustin BélaAugustin Béla Száhlender KárolySzáhlender Károly Kabay János Kabay János Kelp IlonaKelp Ilona Békésy MiklósBékésy Miklós Kuntz JánosKuntz János Boros ÁdámBoros Ádám Szathmáry GézaSzathmáry Géza

Máthé Imre Nyiredy Szabolcs Dános Béla Bernáth Jenő Kiniczky Márta Tyihák Ernő Szatmáry Miklós Máthé Imre jnr Máthé Ákos

First ever medicinal plant state control First ever medicinal plant state control systemsystem(1920-1990s)(1920-1990s)

- y1922 Publishing of Guidelines for wild crfting, collection of medicinal - y1922 Publishing of Guidelines for wild crfting, collection of medicinal plantsplants

„„Útmutatás a vadontermő gyógynövények gyűjtéséreÚtmutatás a vadontermő gyógynövények gyűjtésére” ” ((Augustin-Darvas, Gyógy- és Ipari Növényforgalmi Iroda KiadóAugustin-Darvas, Gyógy- és Ipari Növényforgalmi Iroda Kiadó Budapest, 1922, 199 pps.) Budapest, 1922, 199 pps.)

-- y1922 Publishing of Guidelines for cultivation of plant for medicinal y1922 Publishing of Guidelines for cultivation of plant for medicinal and chemical use and chemical use

„„Gyógy- és vegyipari növények termesztéseGyógy- és vegyipari növények termesztése” (” (Augustin-Darvas-SchneiderAugustin-Darvas-Schneider,, FM kiadás, Pátria Nyomda, Vác, 1922, 176 pps.) FM kiadás, Pátria Nyomda, Vác, 1922, 176 pps.)

- y1923 control and use of state seal in export release- y1923 control and use of state seal in export release

- y1934 extension of control to field activities (cultivation, crafting, - y1934 extension of control to field activities (cultivation, crafting, processing on site)processing on site)

This system was kept in force until years of 90sThis system was kept in force until years of 90s No control exists in recent years.No control exists in recent years.

RIMPH - GYNKI today as isRIMPH - GYNKI today as is

RIMPH - GYNKI the vertically integrated company from RIMPH - GYNKI the vertically integrated company from medicinal plants research to finished products as herbal medicinal plants research to finished products as herbal medicines medicines

involving: involving:

research, development,research, development,genebanking, genebanking, varieties improvements, varieties improvements, identification and QC analysis laboratories, identification and QC analysis laboratories, extraction of APIs, extraction of APIs, manufacturing of finished pharmaceuticals,manufacturing of finished pharmaceuticals,

registration of own new productsregistration of own new products

Mission Mission

Research on plants for medicinal useResearch on plants for medicinal use New added value productsNew added value products

New varieties New varieties

New technologies in agriculture of MAPsNew technologies in agriculture of MAPs

New API extraction technologiesNew API extraction technologies

11 new medicinal products 4 new varieties in pipeline11 new medicinal products 4 new varieties in pipeline

Herbal succes elementsHerbal succes elements

New varieties (efficient, safe)New varieties (efficient, safe) Motivated farmersMotivated farmers Skilled integratorsSkilled integrators High tech processorsHigh tech processors Market driven companiesMarket driven companies Responsible authoritiesResponsible authorities Reasonable regulationReasonable regulation Supportive state adminSupportive state admin

There are markets for There are markets for suresure

- The y2050 vision- The y2050 vision

- More people (?10 Bn)- More people (?10 Bn)

- 10-15% / year market growth- 10-15% / year market growth

- example the poppy - example the poppy

Example -poppy alkaloidsExample -poppy alkaloidsthe growth is evidentthe growth is evident

Poppy the wonder chemical plantPoppy the wonder chemical plant

Opium centuries are downOpium centuries are down

Morfin, Tebain are upMorfin, Tebain are up

Morfin growthMorfin growth

Tebain growthTebain growth

Aussi success storyAussi success story

Hungary lost marketsHungary lost markets