RESEARCH ACTIVITIES OF THE DIVISION OF BIOMATERIALS …

ZBTM• Polymer Institute • Prof. M. El Fray, PhD, DSc, Eng.,• //www.zbtm.zut.edu.pl

DIVISION OF BIOMATERIALS AND MICROBIOLOGICAL TECHNOLOGIES

RESEARCH ACTIVITIES OF THE DIVISION OF BIOMATERIALS AND

MICROBIOLOGICAL TECHNOLOGIES

Date: 1.03.2013

Head of Division

Prof. Miroslawa El Fray

Elastomeric biomaterials BIOMATERIALS FOR HEART

Project manager:

Prof. Mirosława El Fray

NEW ELASTOMERIC BIOMATERIALS FOR HEART ASSISTING DEVICES

Project financialy supported by the NCBiR

Adjuncts: Agnieszka Piegat, PhD, Eng. Marta Piątek-Hnat, PhD, Eng.

BIOMATERIALS FOR HEART

The aim of the project is to develop innovative biomaterials for heart assisting devices. The technological platform based on PET biomaterials modified with hydrophobic fatty acids and vitamin E will be established. Chemical and biological properties will be evaluated along with mechanial and processing performance.

Elastomeric biomaterials

Material-tissue interactions

Post-Doc: Piotr Sobolewski, PhD, Eng.

Project financed from 7 FP Maria Curie IAPP

UNDERSTANDING INTERACTIONS OF HUMAN TISSUE WITH MEDICAL DEVICES

BIOMATERIAL-TISSUE INTERACTIONS

Work Package Leader:


The scientific and technological vision of UNITISS is to meet the needs of today’s healthcare industry and social expectation in reducing patient discomfort and infection. UNITISS aims to develop effective in vitro tests that reliably simulate the in vivo conditions, and to develop device design strategies using improved materials and coatings that minimize the discomfort, irritation, inflammation, infection and tissue damage occurring to patients. This will be possible through developing a greater understanding of the response of human tissue to physical interactions and to new non-invasive methods of tissue monitoring .

Material-tissue interactions BIOMATERIAL-TISSUE INTERACTIONS

Injectable Biomaterials BIOMATERIALS FOR REGENERATIVE MEDICINE

Project manager:


NEW INJECTABLE BIOMATERIALS

PhD student:

Jędrzej Skrobot, MSc, Eng.

The project is financially supported by Ministry of Science and Higher Education grant N N507 434734

Injectable Biomaterials BIOMATERIALS FOR REGENERATIVE MEDICINE

The work aims at producing photoreactive macromers with potential applications as injectable biomaterials for soft tissue reconstruction 1. Evaluation of chemical structure and molar masses of macromers containing i.e. urethane and anhydride groups (NMR, FTIR, ESI-MS, GPC) 2. Selecting photoinitiators and photocrosslinking parameters 3. Evaluation of chemical structure of photopolymerized systems (ATR-IR) 4. Evaluation of physico-chemical, thermal and mechanical properties 5. In vitro and in vivo biocompatibility studies

Polymeric Self-assemblies

PhD student: Joanna Gajowy, MSc, Eng.

POLYMERIC SELF-ASSEMBLIES

http://www.york.ac.uk/chemistry/staff/academic/o-s/dsmith/

BIOMATERIALS FOR REGENERATIVE MEDICINE

Project manager:


This project is financially suported from NCN 2011/03/B/ST8/06353

The goal of the work is to obtain and characterize polymeric self-

assemblies (PAET) derived from natural compounds, mainly amino

acids (tyrosine) and dicarboxylic acids (including fatty acids).

The PAET amphiphilic copolymers will be designed and used for the formulation of micelles/nanospheres of high efficiency of encapsulation and drug release.

Polymeric self-assemblies based on di- and trifunctional derivatives of fatty acids, amino acids and amines/urea as well as modified by polyethers (PEG) and dendrimers will be characterized.

BIOMATERIALS FOR REGENERATIVE MEDICINE

Polymeric Self-assemblies

Polymeric supports for graphene sensor

This project is financially suported from GRAF-TECH/NCBR/08/06/2013

MULTIFUNCTIONAL BIOSENSOR FOR MEDICAL DIAGNOSTICS

BIOMATERIALS FOR MEDICAL DIAGNOSTICS

Project manager:


Project leader:

Prof. Ewa Mijowska

The aim of the project is to develop multifunctional biosensor based on graphene technology, by applying different bio-assays, including bio-FET, Electrochemical Impedance Spectroscopy (EIS) – bioelectrical impedance (BI). A multifunctional graphene biosensor will be developed for effective electrochemical detection of specific DNA microbial targets in biological samples and blood glucose monitoring. Developed technology will allow fabrication of low cost sensing components for point-of-care diagnosis.

Polymeric supports for graphene sensor BIOMATERIALS FOR MEDICAL DIAGNOSTICS

Antimicrobial Coatings

PhD Student: Agata Niemczyk, MSc, Eng.


ANTIMICROBIAL COATINGS ON THERMOPLASTIC ELASTOMERS

BIOMATERIALS FOR RECONSTRUCTIVE MEDICINE

Project manager:


Antimicrobial Coatings

The aim of the work is to develop a new group of elastomeric biomaterials with improved antimicrobial properties for the implants, mainly cardiac and urological.

1. Synthesis of polyester thermoplastic elastomers

2. Characterization of physical and chemical properties:

NMR, ATR-FTIR analysis

DSC and DMTA

Mechanical properties , hardness Shore D

3. Synthesis of chitosan- linoleic acid systems in form of nano-particles dispersions

4. Modification of polymers with chitosan- linoleic acid dispersions

5. Investigation of antimicrobial activity of new group of modified polyesters


Enzymatic synthesis of polymers

PhD student: Bogusława Gradzik, MSc, Eng.

ENZYMATIC SYNTHESIS OF POLY(BUTYLENE SUCCINATE) COPOLYMERS

Project manager:



• Celem pracy jest wykorzystanie enzymów jako naturalnych bio-

katalizatorów dla syntezy bioresorbowalnych i biozgodnych

kopolimerów na podstawie poli(bursztynianu butylenu) (PBS).

• Zostaną zaprojektowane i wykonane syntezy kopolimerów z

wykorzystaniem biodegradowalnych segmentów, tj. oligoterów lub

oligowęglanów.

• Dodatkowo, do takich układów zostaną wprowadzone

nanonapełniacze w postaci naturalnych glinokrzemianów lub

ceramiki w celu uzyskania materiałów bioaktywnych o

potencjalnym wykorzystaniu w technikach medycznych.


Enzymatic synthesis of polymers

Radiation Modification of Nanocomposites BIOMATERIALS FOR RECONSTRUCTION MEDICINE

PhD student: Michał Rybko, MSc, Eng.

INFLUENCE OF THE RADIATION MODIFICATION ON SELECTE PROPERTIES OF POLYMER

NANOCOMPOSITES


Project manager:


The aim of the work is to prepare polymer nanocomposites based on multiblock copolyesters by polycondensation in situ and their radiation modification in order to: 1. improve mechanical properties, especially creep resistances 2. modify the surface by the radiation grafting to achieve hydphilic

properties The work includes: 1. Synthesis of nanocomposites with the use of nanoparticles of

different aspect ratio 2. Evaluation of physicochemical and mechanical properties, before

and after the radiation 3. Modification of the surface by the radiation grafting

BIOMATERIALS FOR RECONSTRUCTION MEDICINE

Radiation Modification of Nanocomposites

Polymeric Nanocomposites

PhD student: Zygmunt Staniszewski, MSc, Eng.

POLESTER NANOCOMPOSITES WITH GRAPHENE AND CARBON NANOTUBES


Project manager:


The aim of the work is to prepere multiblock copolyesters by in-situ polycondensation as biostabile materials for implantology and/or medical equipment.

The main subjects of the work are:

1. Synthesis of nanocomposites with carbon nanoparticles (graphene/graphene oxide) and carbon nanotubes (CNT)

2. Examination of nanostructure of prepered materials

3. Evaluation of physicochemical and mechanical properties

4. Evaluation of in vitro biostability


Polymer Nanocomposites

Polymer Blends

PhD:

Wojciech Ignaczak. MSc, Eng.

Project financed from 7PR EeB. NMP.2012-5. NMP

MODERN POLYMERIC BLENDS CONTAINING POLYESTERS

POLYMER BLENDS

Work Package Leader:


The aim of the project is to develop new polymeric blends based on polyesters and polyolefins which wll be compatibilized by multiblock copolymers. New materials will be used for fabrication of composite materials containing basalt fibres.

POLYMER BLENDS

Polymer Blends

Biodegradable Copolyesters POLYMERS FOR ENCAPSULATION TECHNOLOGY

Project manager :

Agnieszka Kozłowska, PhD, Eng.

SYNTHESIS AND PROPERTIES OF NEW POLYESTER COPOLYMERS FOR ENCAPSULATION TECHNOLOGY

The project is financially supported by Ministry of Science and Higher Education grant N N209216538

Biodegradable aliphatic copolyesters based on dimmerized fatty acid:

– polycondensation of copolymers in the melt ,

– characterization of physical, chemical, mechanical, thermal properties

– hydrolytic and biological degradation,

– application of polymers in microencapsulation technology

Biodegradable Copolyesters POLYMERS FOR ENCAPSULATION TECHNOLOGY

Polymer Elastomeric Networks

ELASTOMERS FROM RENEWABLE RAW MATERIALS

Project manager :

Marta Piątek-Hnat, PhD, Eng.

NEW ESTER ELASTOMERS FROM RENEWABLE RESOURCES

The aim of the work is to develop a three-step process and investigate the elastomeric ester networks of poly (glycerol sebacate) (PGS) and poly (sorbitol sebacate) (PSS) for the potential use in medical application as scaffolds, and drug delivery systems for biologically active materials.



1. Synthesis of elastomers based on glycerol/sorbitol and sebacic acid

2. Chemical structure of elastomers

3. Study of physicochemical , thermal and mechanical properties (dynamic creep and relaxation)

4. Hydrolytic and enzymatic degradation

5. Study of physicochemical and structural polymers after hydrolytic and enzymatic degradation



Multifunctional Initiators RADICAL POLYMERIZATION RESEARCH

Project manager :

Ewa Wiśniewska, PhD, Eng.

Research works are carried out in cooperation with Silesian University of Technology in Gliwice, Faculty of

Chemistry, Department of Chemical Organic Technology and Petrochemistry

CH3

C N

CH3

CH3

N C

CH3

CN

CH2

C O

O

O C CH3

CH3

CH3

4

MULTIFUNCTIONAL INITIATORS

IN RADICAL POLYMERIZATION

Multifunctional Initiators RADICAL POLYMERIZATION RESEARCH

Objectives of the work: Azo-perester initiators of radical polymerization with symmetrical

chemical structure and with asymmetrical chemical structure

H3C

CH3

CH3

C O

O

CO CH24

C N N C

CNCN

CH3 CH3

C

O

OOC CH3

CH3

CH24

CH3

CH3

C N

CH3

CH3

N C

CH3

CN

CH2

C O

O

O C CH3

CH3

CH3

4

- Studies of initiator’s thermal decomposition by volumetric and UV-Vis spectroscopic methods;

- Kinetic studies of vinyl monomers polymerization by dilatometry; - Studies of chemical structure of initiators, monomers and polymers; - Determination of the average molecular mass of polymers.

Studies on TiO2 Activity Against Fungal Growth MICROBIOLOGICAL STUDIES

Project manager:

Agata Markowska-Szczupak, PhD, Eng.

(Institute of Chemical and Environment Engineering)

Performer:

Krzysztof Ulfig, PhD, DSc

Assoc. Professor

DETERMINATION OF THE INFLUENCE OF LIGHT-INDUCED TITANIUM DIOXIDE AND WATER ACTIVITY

ON THE GROWTH OF FUNGI OCCURRING IN THE INDOOR ENVIRONMENT

The research project no. N N209 106439

MICROBIOLOGICAL STUDIES

The goal of the study is to receive data enabling determination of

titanium dioxide antifungal activity in environments with

different water activity, especially in indoor environments (flats,

public buildings, offices, schools, kinder gardens, etc.).

As a result of project realization, it is planned to determine the

optimal TiO2 concentrations in emulsion paints in order to receive

high quality products, with simultaneous decrease of chemical

biocide quantities.

Studies on TiO2 Activity Against Fungal Growth

Biodegradation of Polyesters by Fungi MICROBIOLOGICAL STUDIES

Project manager:

Krzysztof Ulfig, PhD, DSc,

Assoc.Professor

in cooperation with:

A. Kozłowska, PhD, Eng.

BIODEGRADATION OF CONDENSATION POLYESTERS BY MICROSCOPIC FUNGI

Biodegradation of Polyesters by Fungi MICROBIOLOGICAL STUDIES

The goal of the study is to evaluate the susceptibility of

condensation copolyesters to biodegradation involving

microscopic fungi. The copolyesters under examination are

composed of succinic or sebacic acid, dimerized fatty acid and

fumaric acid.

The copolyesters are examined for physico-chemical and thermal

properties. Microscopic observations are also performed

regarding the penetration and biodegradation of polyesters by

microscopic fungi.

Fungal Diversity Studies MICROBIOLOGICAL STUDIES

Project manager:

Krzysztof Ulfig, PhD, DSc,

Assoc. Professor

Cooperation with:

A. Markowska-Szczupak, PhD, Eng.

STUDIES OF FUNGAL DIVERSITY IN ENVIRONMENTS CONTAMINATED WITH XENOBIOTICS AND ORGANIC

WASTES

Fungal Diversity Studies MICROBIOLOGICAL STUDIES

Based on archival data, the project aims to determine

fungal diversity changes in environments during

bioremediation and in environments contaminated with

organic wastes (municipal waste, sewage and sewage

sludge). The fungi are tested as ecotoxicological

indicators.

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RESEARCH ACTIVITIES OF THE DIVISION OF BIOMATERIALS …