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Replication & Transcription

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Replication One of the hallmarks of living organisms is their ability to reproduce. DNA contains the genetic information

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The interrelationship of DNA,RNA & Protein

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DNA Contains Four Deoxynucleotides

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Double-stranded DNA

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Formation of hydrogen bonds between complementary bases in double-stranded DNA

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Base pairing

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Supercoiling of DNA. DNA Exists in Relaxed & Supercoiled Forms

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Negative and positive supercoils.

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Important structural elements of a yeast chromosome

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extent of DNA packaging in metaphase chromosomes

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Requirements for DNA Replication

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DNA provides a template for Replication & transcription

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DNA replication is semiconservative

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Steps involved in DNA replication in eukaryotes

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Classes of proteins involved in replication

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The initiation of DNA synthesis upon a primer of RNA

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DNA polymerase III

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A comparison of prokaryotic and eukaryotic DNA polymerases

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DNA Polymerases

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The telomere replicacion problem

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Cyclins and cyclin-dependent kinases involved in cell cycle progression

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Cell cycle

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RNA Synthesis, Processing, & Modification

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Prokaryotic gene PromoterCoding regionTermination

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Introns in two eukaryotic genes.

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Promoter structure

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Bacterial promoters

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Eukaryotic Promoters Are More Complex

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the transcription control regions

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Summary of the properties of enhancers.

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Nomenclature and properties of mammalian nuclear DNA-dependent RNA polymerases.

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Structure of a typical eukaryotic mRNA showing elements that are involved in regulating mRNA stability

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Typical aminoacyl tRNA

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Classes of eukaryotic RNA.

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Components of mammalian ribosomes

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