Regenerative therapies for heart and vessels - prof. Piotr Musiałek

Embed Size (px)

Text of Regenerative therapies for heart and vessels - prof. Piotr Musiałek

  • Przeszczepia -czy- Regenerowa ? Klinika Chorb Serca i Naczy CMUJSzpital im. Jana Pawa IIKrakowRegenerative Therapies for Heart &Vessels

  • WHY ?

  • 10-year survival in failure

  • www.poltransplant.org.pl

  • www.poltransplant.org.pl

  • www.poltransplant.org.pl

  • 10-year survival in PAD

  • Amputations in PAD(Poland)10 000 / year1 leg / hour

  • THE NEED

  • THE NEEDexisting state-of-the-art therapiesare greatly insuficient

  • FEASIBLE ?

  • 1. post-mitotic organ(s)

    2. in all mammals... HEALINGis naturally biased towardsFIBROTIC SCAR formationFEASIBILITY ?

  • Cardiac & Vascular regeneration therapy in 2014...

  • but...

  • Cardiac & Vascular regeneration therapy in 2014...

  • Cardiac & Vascular regeneration therapy in 2014...

  • Cardiac & Vascular regeneration therapy in 2014...

  • post-mitotic organ

  • The heart is NOT a post-mitotic organ

  • The heart is NOT a post-mitotic organ + A P O P T O S I S !

  • 2001

  • Bone marrow mediated endogenous pro-regenerative resposne after AMI

  • Bone marrow mediated endogenous pro-regenerative resposne after AMISDF expression in infarct zone

  • Optimal cell type and dose ?Myocardial regeneration therapy in 2014+Jagiellonian University Dept. of Cardiac & Vascular DiseasesJohn Paul II HospitalKrakow

  • Intrinsic cardiac stem cells

  • 10 years Jagiellonian University Dept. of Cardiac & Vascular DiseasesJohn Paul II HospitalKrakow+

  • How to (best)deliver the cells?Myocardial regeneration therapy in 2014+Jagiellonian University Dept. of Cardiac & Vascular DiseasesJohn Paul II HospitalKrakow

  • Development

  • Labeled cells (SPECT) and cMRI: I M A G E F U S I O NP Bany 2010-2012Labeled CD34+ cells (3D SPECT) myocardialCD34+ uptake (part of) CD34+ liver uptakeObrazowanie hybrydowe: zawa (MRI) / komrki (SPECT)

  • P. Musiaek and TeamCirculation: Cardiovasc Img 2013

  • Infarct Size (not LVEF) Determines Cell UptakeP. Musiaek and TeamCirculation: Cardiovasc Img 2013

  • CD34+ increased uptake in the infarct border-zonemay inhibit adverse remodeling Musialek i wsp. 2013 (at review) ESV @24 mies EDV @24 mies

  • TERAPIA KOMRKOWA zawau: stan wiedzy (2013)INCREASE IN LVEF @ 6moZimmet Eur J Heart Fail 2012* przezwiecowe podanie komrek *

  • Biocompatible scaffolds

  • Biopatches for IPCs

  • CE Mark since April 2012Available on the market

  • Needle design based on mathematical modelingVariable caliber and distribution of infusion holes: Drug Product is more evenly distributed along the needle extremity Enhanced fluid distribution inside myocardium

    Development

  • transendocardial

  • Critical Limb Ischaemia

  • Critical Limb Ischaemiavariable (naturally) disease progression rateconcomittant revasculatization of the feeding vessel(s)other confounders (such as exercise proangiogenic)...

  • Novel Off-shelfRegenerative Cell Application in Treatmentof No-option Critical Limb Ischemiaemail: mrt@onet.plINVESTIGATOR INITIATED STUDYMariusz TRYSTUA, Marcin MAJKA (PIs)Jagiellonian University Dept. of Cardiac & Vascular Surgery and Transplantation at John Paul II Hospitaland Jagiellonian University Dept. of TransplantationKrakow

  • Stem cell cased therapeutic strategies

  • Cardiac & Vascular regeneration therapy in 2014...

  • Cardiac & Vascular regeneration therapy in 2014...

  • Cardiac & Vascular regeneration therapy in 2014...

Recommended

View more >