References

References

126

REFERENCES

Abal M, Andreu JM, Barasoain I (2003). Taxanes: Microtubule and Centrosome Targets,

and Cell Cycle Dependent Mechanisms of Action. Curr Cancer Drug Targets 3, 193-203.

Abou-Donia MB, Dieckert JW (1974). Gossypol: Uncoupling of respiratory chain and oxidative phosphorylation. Life Sci 14, 1955-1963.

Agullo G, Gamet L, Besson C, Deminge C, Ramesy C (1994). Quercetin exerts a preferrential cytotoxic effect on actively dividing colon carcinoma HT-29 and Caco-2 cells. Cancet Lett 87, 55-63.

Ahmad A, Asad SF, Singh S, Hadi SM (2000). DNA breakage by resveratrol and Cu(II): reaction mechanism and bacteriophage inactivation. Cancer Lett 154, 29-37.

Ahmad A, Asad SF, Singh S, Hadi SM (2005). Prooxidant activity of resveratrol in the presence of copper ions: mutagenicity in plasmid DNA. Toxicol Lett 159, 1-12.

Ahmad MS, Fazal S, Rahman A, Hadi SM, Parish JH (1992). Activities of flavonoids for the cleavage of DNA in the presence of Cu(II): correlation wi±th the generation of active oxygen species. Carcinogenesis 13, 605-608.

Ahmad N, Cheng P, Mukhtar H (2000). Cell cycle dysregulation by green tea polyphenol epigallocatechin-3-gallate. Biochem Biophys Res Commun 275, 328–334.

Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar H (1997). Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst 89, 1881-1886.

Ahsan A, Hadi SM (1998). Strand scission in DNA induced by curcumin in the presence of Cu(II). Cancer Lett 124, 23-30.

Ames BN (1983). Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases. Science 221, 1256-1264.

Armstrong JS (2006). Mitochondrial membrane permeabilization: the sine qua non for cell death. BioEssays 28, 253–260.

Arnold AA, Aboukameel A, Chen J, Yang D, Wang S, Al-Katib A, Mohammad RM (2008). Preclinical studies of Apogossypolone: a new nonpeptidic pan small-molecule inhibitor of Bcl-2, Bcl-XL and Mcl-1 proteins in Follicular Small Cleaved Cell Lymphoma model. Mol Cancer 7, 20.

Azam S, Malik A, Hadi SM (2004). Prooxidant property of green tea polyphenols epicatechin and epicatechin-3-gallate: implications for anticancer properties. Toxicol In Vitro 18, 555-561.

Azmi AS, Bhat SH, Hanif S, Hadi SM (2006). Plant polyphenols mobilize endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: Implications for a putative mechanism for anticancer properties. FEBS Lett 580, 533-538.

Badary OA, Taha RA, Gamal el-Din AM, Abdel-Wahab MH (2003). Thymoquinone is a potent superoxide anion scavenger. Drug Chem Toxicol 26, 87–98.

 

References

127

Balakrishnan K, Wierda WG, Keating MJ, Gandhi V (2008). Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cells. Blood 112, 1971-1980.

Balandrin MF, A. Kinghorn D, Farnsworth NR (1993). Plant-Derived Natural Products in Drug Discovery and Development: An Overview. In Human Medicinal Agents from Plants; Kinghorn, A. ACS Symposium Series; American Chemical Society: Washington, DC.

Balci A, Sahin FI, Ekmekci A (1999). Gossypol induced apoptosis in the human promyelocytic leukemia cell line HL 60. Tohoku J Exp Med 189, 51-57.

Balkwill F, Mantovani A (2001). Inflammation and cancer: back to Virchow? Lancet 357, 539–545.

Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S, Sarkar FH, Mohammad RM (2009). Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Cancer Res 69, 5575–5583.

Banerjee S, Li Y, Wang Z, Sarkar FH (2008). Multi-targeted therapy of cancer by genistein. Cancer Lett 269, 226–242.

Barbehenn R, Cheek S, Gasperut A, Lister E, Maben R (2005). Phenolic compounds in red oak and sugar maple leaves have prooxidant activities in the midgut fluids of Malacosoma disstria and Orgyia leucostigma caterpillars. J Chem Ecol 31, 969–988.

Barchowsky A, Dudek EJ, Treadwell MD, Wetterhahn KE (1996). Arsenic induces oxidant stress and NF-kappa B activation in cultured aortic endothelial cells. Free Radic Biol Med 21, 783-790.

Bell AA (1967). Formation of gossypol in infected or chemically irritated tissues of gossypium species. Phytopathol 57, 759-764.

Benz CC, Keniry MA, Ford JM, Townsend AJ, Cox FW, Palayoor S, Matlin SA, Hait WN, Cowan KH (1990). Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers. Mol Pharmacol 37, 840-847.

Beretta GL, Zuco V, Perego P, Zaffaroni N (2011). Targeting DNA Topoisomerase I with Non-Camptothecin Poisons. Curr Med Chem [Epub ahead of print]

Bezerra DP, Alves AP, de Alencar NM, Mesquita Rde O, Lima MW, Pessoa C, de Moraes MO, Lopes JN, Lopes NP, Costa-Lotufo LV (2008). Antitumor activity of two derivatives from 2-acylamine-1,4-naphthoquinone in mice bearing S180 tumor. J Exp Ther Oncol 7:, 113–121.

Bhat R, Hadi SM (1994). DNA breakage by tannic acid and Cu (II): sequence specificity of the reaction and involvement of active oxygen species. Mutat Res 313, 39-48.

Bickford WG, Pack FC, Castillon LE, Mack CH (1954). The antioxidant and antipolymerization properties of gossypol, dianilinogossypol, and related materials. J Am Oil Chem Soc 31, 91-93.

Boivin WA, Cooper DM, Hiebert PR, Granville DJ (2009). Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma. Lab Invest 89, 1195-1220.

Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ (2000). Role of quinones in toxicology. Chem Res Toxicol 13, 135–160.

Bryan SE (1979). Metal ions in biological systems. New York: Marcel Dekker.

References

128

Burgos M, Ito S, Segal JS, Tran TP (1997). Effect of Gossypol on Ultrastructure of Spisula Sperm. Biol Bull 193, 228–229.

Burke YD, Stark MJ, Roach SL, Sen SE, Crowell PL (1997). Inhibition of pancreatic cancer growth by the dietary isoprenoids farnesol and geraniol. Lipids 32, 151–156.

Burkitt MJ, Milne L, Nicotera P, Orrenius S (1996). 1, 10-Phenanthroline stimulates internucleosomal DNA fragmentation in isolated rat liver nuclei by promoting redox activity of endogenous copper ions. Biochem J 313, 163–169.

Burt S (2004). Essential oils: their antibacterial properties and potential applications in foods – a review. Int J Food Microbiol 94, 223–253.

Caltagirone S, Ranelletti FO, Rinelli A, Maggiano N, Colasante A, Musiani P, Aiello FB, Piantelli M (1997). Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer. Am J Respir Cell Mol Biol 17, 51-59.

Cao Y, Cao R (1999). Angiogenesis inhibited by drinking tea. Nature 398, 381.

Carson CF, Mee BJ, Riley TV (2002). Mechanism of action of Melaleuca alternifolia (tea tree) oil on Staphylococcus aureus determined by time-kill, lysis, leakage and salt tolerance assays and electron microscopy. Antimicrob Agents Chemother 46, 1914–1920.

Chang KL, Cheng HL, Huang LW, Hseih BS, Hu YC, Chih TT, Shyu HW, Su SJ (2009). Combined effects of terazosin and genistein on a metastatic, hormone –independent human prostate cancer cell line. Cancer Lett 276, 14-20.

Chaturvedi PK, Bhui K, Shukla Y (2008). Lupeol: connotations for chemoprevention. Cancer Lett 263, 1–13.

Chen L, Zhang HY (2007). Cancer preventive mechanisms of the green tea polyphenol (−)-epigallocatechin-3-gallate. Molecules 12, 946–957.

Chevion M (1998). Site specific mechanism for free radical induced biological damage. The essential role of redox-active transition metals. Free Radic Biol Med 5, 27-37.

Cichewicz RH, Kouzi SA (2004). Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev 24, 90 –114.

Clarkson PM, Thompson HS (2000). Antioxidants: what role do they play in physical activity and health? Am J Clin Nutr 72, 637S-646S.

Clement MV, Hirpara JL, Chawdhury SH, Pervaiz S (1998). Chemopreventive agent resveratrol, a natural product derived from grapes, triggers CD95 signalling-dependent apoptosis in human tumor cells. Blood 92, 996-1002.

Coussens LM, Werb Z (2002). Inflammation and cancer. Nature 420, 860-867.

Coutinho EM (2004). Gossypol: a contraceptive for men. Contraception 65, 259-263.

Cowan MM (1999). Plant products as antimicrobial agents. Clin Microbiol Rev 12, 564–582.

Cragg GM, Newman DJ (2005). Plants as a source of anti-cancer agents. J Ethnopharmacol 100, 72–79

Croteu R, Kutchan TM, Lewis N. G. 2000. Natural products (secondary metabolites). In: Biochemistry and Molecular Biology of Plants (Buchanan B, Gruissem W, Jones R eds.), American Society of Plant Physiologists, USA. Pp 1250-1319.

References

129

Czene S, Tiback M, Harms-Ringdahl M (1997). pH-dependent DNA cleavage in permeabilized human fibroblasts. Biochem J 323, 337-341.

Dalimov DN, Mukhamedzhanova EN, Shneivais VB, Biktimirov L, Isamilov AI, Kamaev FG (1989). Synthesis, structure, and action of some gossypol derivatives on the perozidation of the lipids of biosubstrates. Khimiya Prirodnykh Soedinenii 5, 707-712.

Dando C, Schroeder ER, Hunsaker LA, Deck LM, Royer RE, Zhou X, Parmley SF, Vander Jagt DL (2001). The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum. Mol Biochem Parasitol 118, 23-32.

Davis JM, Murphy EA, Carmichael MD (2009). Effects of the dietary flavonoid quercetin upon performance and health. Curr Sports Med Rep 8, 206–213.

DeFeudis FV, Papadopoulos V, Drieu K (2003). Ginkgo biloba extracts and cancer: a research area in its infancy. Fundam Clin Pharmacol 17, 405–417.

Devi GS, Prasad MH, Saraswathi I, Rao DN, Reddy PP (2000). Free radicals, antioxidant enzymes and lipid peroxidation in different types of leukemia. Clin Chim Acta 293, 53–62.

Di Pasqua R, Hoskins N, Betts G, Mauriello G (2006). Changes in membrane fatty acids composition of microbial cells induced by addiction of thymol, carvacrol, limonene, cinnamaldehyde, and eugenol in the growing media. J Agric Food Chem 54, 2745-2749.

Dodou K, Anderson RJ, Lough WJ, Small DA, Shelley MD, Groundwater PW (2005). Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity. Bioorg Med Chem 13, 4228-4237.

Dragsted IO, Strube M, Larson JC (1993). Cancer protective factors in fruits and vegetables: biochemical and biological background. Pharmacol Toxicol 72, 116-135.

D’Urso G, Frascarelli S, Zucchi R, Biver T, Montali U (2008). Cardioprotection by ouabain and digoxin in perfused rat hearts. J Cardiovasc Pharmacol 52, 333-337.

Duthie SJ, Collins AR, Duthie GG, Dobson VL (1997a). Quercetin and Myrecitin protect against hydrogen peroxide induced DNA damage (strand breaks and xidized pyrimidines) in human lymphocytes. Mutat Res 393, 223-231.

Duthie SJ, Dobson VL (1999). Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro. Eur J Nutr 38, 28-34.

Duthie SJ, Johnson W, Dobson VL (1997b). The effect of dietary constituents on DNA damage (strand breaks and oxidized pyrimidines) and growth in human cells. Mutat Res 390, 141-151.

Ebara M, Fukuda H, Hatano R, Saisho H, Nagato Y, Suzuki K, Nakajima K, Yukawa M, Kondo F, Nakayama A, Sakurai H (2000). Relationship between copper, zinc and metallothionein in hepatocellular carcinoma and its surrounding liver parenchyma. J Hepatol 33, 415–422.

Edwards R, Gatehouse JA (1999). Secondary metabolism. In Plant Biochemistry and Molecular Biology (PJ Lea and RC Leegood, eds). Chichester, West Sussex: John Wiley & Sons Ltd. Pp. 193–218.

References

130

El-Dakhakhany M (1963). Studies on the chemical constitution of Egyptian N. sativa L. seeds. Planta Medica, 11, 465–470.

El-Kadi A, Kandil O, Tabuni AM (1989). Nigella sativa and cell mediated immunity. Archives of AIDS Research, 1, 232–233.

El-Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA (2005). Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Cancer 117, 409–417.

El-Mahmoudy A, Matsuyama H, Borgan MA, Shimizu Y, El-Sayed MG, Minamoto N, Takewaki T (2002). Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. Int Immunopharmacol 2, 1603–1611.

El-Najjar N, Chatila M, Moukadem H, Vuorela H, Ocker M, Gandesiri M, Schneider-Stock R, Gali-Muhtasib H (2010). Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis. 15, 183-195.

Evans MD, Dizdaroglu M, Cooke MS (2004). Oxidative DNA damage and disease: induction, repair and significance. Mutat Res 567, 1–61.

Evans ZP, Ellett JD, Fariss MW, Schnellmann RG, Schmidt MG, Chavin K (2008). Vitamin E succinate reduces ischemia/reperfusion injury in steatotic livers. Transplant Proc 40, 3327-3329.

Fan XH, Wang X, Chen F, Galler DP, Wan PJ (2008). Engine performance test of cottonseed oil biodiesel. The Open Energy and Fuels Journal 1, 40-45.

Finch CE, Crimmins EM (2004). Inflammatory exposure and historical changes in human life-spans. Science 305, 1736–1739.

Flack MR, Pyle RG, Mullen NM, Lorenzo B, Wu YW, Knazek RA, Nisula BC, Reidenberg MM (1993). Oral gossypol in the treatment of metastatic adrenal cancer. J Clin Endocrinol Metab 76, 1019-1024.

Frankel EN, German JB (2006). Antioxidants in foods and health: problems and fallacies in the field. J Sci Food Agric 86, 1999–2001.

Freidovich I (1999). Fundamental aspects of reactive oxygen species, or what’s the matter with oxygen? Ann NY Acad Sci 893, 13-18.

Fukumoto LR, Mazza G (2000). Assessing antioxidant and prooxidant activities of phenolic compounds. J Agric Food Chem 48, 3597–3604.

Gali HU, Perchellet EM, Klish DS, Johnson JM, Perchellet JP (1992). Hydrolyzable tannins: potent inhibitors of hydroperoxide production and tumor promotion in mouse skin treated with 12-O-tetradecanoyl phorbol-13- acetate in vivo. Int J Cancer 51, 425-432.

Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, Schneider-Stock R (2004b). Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 25, 857–866.

Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA (2004a). Molecular pathway for thymoquinone induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 15, 389–399.

Gerez de Burgos NM, Burgos C, Montamat EE, Rovai LE, Blanco A (1984). Inhibition by gossypol of oxidoreductases from Trypanosoma cruzi. Biochem Pharmacol 33, 955-

References

131

959.

Ghavami S, Hashemi M, Ande SR, Yeganeh B, Xiao W, Eshraghi M. Bus CJ, Kadkhoda K, Wiechec E, Halayko AJ, Los M (2009). Apoptosis and cancer: mutations within caspase genes. J Med Genet 46, 497–510.

Ghosheh OA, Houdi AA, Crooks PA (1999). High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal 19, 757–762.

Gullett NP, Ruhul Amin AR, Bayraktar S, Pezzuto JM, Shin DM, Khuri FR, Aggarwal BB, Surh YJ, Kucuk O (2008). Cancer Prevention With Natural Compounds. Semin Oncol 37, 258-281.

Gupte A, Mumper RJ (2008). Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. Cancer Treat Rev 35, 32-46.

Gustafson JE, Liew YC, Chew S, Markham JL, Bell HC, Wyllie SG, Warmington JR (1998). Effects of tea tree oil on Escherichia coli. Lett Appl Microbiol 26, 194–198.

Hadi SM, Asad SF, Singh S, Ahmad A (2000). A Putative mechanism for anticancer and apoptosis inducing properties of plant-derived polyphenolic compounds. IUBMB Life 50, 1–5.

Hadi SM, Bhat SH, Azmi AS, Hanif S, Shamim U, Ullah MF (2007). Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties. Semin Cancer Biol 17, 370-376.

Hajhashemi V, Ghannadi A, Jafarabadi H (2004). Black cumin seed essential oil as a potent analgesic and anti-inflammatory drug. Phytother Res 18, 195-199.

Haq A, Lobo PI, Al-Tufail M, Rama NR, Al-Sedairy ST (1999). Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol 21, 283–295.

Hara Y, Matsuzaki S, Nakamura K (1989). Anti-tumor activity of tea catechins. Jpn Soc Nutr Food Sci 42, 39–45.

Harborne JB (1973). Phytochemical methods. Chapman and Hall Ltd., London. pp. 49-188.

Hartwell LH, Kastan MB (1994). Cell cycle control and cancer. Science 266, 1821-1828.

Harvey AL (2008). Natural products in drug discovery. Drug Discov Today 13, 894-901.

Helander IM, Alakomi HL, Latva-Kala K, Mattila-Sandholm T, Pol I, Smid EJ, Gorris LGM, Von Wright A (1998). Characterization of the action of selected essential oil components on Gram negative bacteria. J Agric Food Chem 46, 3590–3595.

Hirano T, Abe K, Gotoh M, Oka K (1995). Citrus flavone tangeretin inhibits leukemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes. Br J Cancer 72, 1380-1388.

Hirano T, Gotoh M, Oka K (1994). Natural flavonoids and lignans are potent cytostatic agents against human leukemic HL-60 cells. Life Sci 55, 1061-1069.

Hoareau L, DaSilva EJ (1999). Medicinal plants: a re-emerging health aid. Eur J Biotech 2.

Hochhauser D (1997). Modulation of chemosensitivity through altered expression of cell cycle regulatory genes in cancer. Anticancer Drugs 8, 903-910.

 

References

132

Hou DX, Uto T, Tong X, Takeshita T, Tanigawa S, Imamura I, Ose T, Fujii M (2004). Involvement of reactive oxygen species-independent mitochondrial pathway in gossypol-induced apoptosis. Arch Biochem Biophys 428, 179-187.

Houghton PJ, Zarka R, de las Heras B, Hoult JR (1995). Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Medica 61, 33–36.

Hove EL (1944). Gossypol as a carotene-protecting antioxidant, in vivo and in vitro. J Biol Chem 156, 633-642.

Hove EL, Hove Z (1944). A method for estimating total fat-soluble antioxidants based on the relation between fat peroxides and carotene destrction. J Biol Chem 156, 611-622.

Huang YW, Wang LS, Chang HL, Ye W, Dowd MK, Wan PJ, Lin YC (2006). Molecular mechanisms of (-)-gossypol-induced apoptosis in human prostate cancer cells. Anticancer Res 26, 1925-1933.

Imanshahidi M, Hosseinzadeh H (2008). Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res 22, 999–1012.

Inoue M, Suzuki R, Koide T, Sakaguchi N, Ogihar, Y, Yabu Y (1994). Antioxidant, gallic acid induces apoptosis in HL 60 R cells. Biochem Biophys Res Commun 204, 898–904.

Inouye S, Takizawa T, Yamaguchi H (2001). Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. J Antimicrob Chemother 47, 565–573.

Jang M, Cai L, Udeani GO, Slowing KV, Thomas CF, Beecher CW, Fong HH, Farnsworth NR, Kinghorn AD, Mehta RG, Moon RC, Pezzuto JM (1997). Cancer chemopreventive activity of Resveratrol, a natural product derived from grapes. Science 275, 218–220.

Jarvis WD, Turner AJ, Povirk LF, Traylor RS, Grant S (1994). Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C. Cancer Res 54, 1707–1714.

Jeon JH, Lee CH, Lee HS (2009). Food protective effect of geraniol and its congeners against stored food mites. J Food Prot 72, 1468–1471.

Ji P, Si M, Podnos Y, Imagawa DK (2002). Monoterpene geraniol prevents acute allograft rejection. Transplant Proc 34, 1418–1419.

Johnson IT (2007). Phytochemicals and cancer. Proc Nutr Soc 66, 207–215.

Jordan MA, Thrower D, Wilson L (1991). Mechanism of Inhibition of Cell Proliferation by Vinca Alkaloids. Cancer Res 51, 2212-2222

Jung YD, Ellis LM (2001). Inhibition of tumour invasion and angiogenesis by epigallocatechin gallate (EGCG), a major component of green tea. Int J Exp Pathol 82, 309–316.

Kagawa TF, Geierstanger BH, Wang AH, Ho PS (1994). Covalent modification of guanine bases in double-stranded DNA: the 1:2-AZ-DNA structure of d(CGCGCG) in the presence of CuCl2. J Biol Chem 266, 20175–20184.

 

References

133

Kamal A, Ramu R, Tekumalla V, Khanna GB, Barkume MS, Juvekar AS, Zingde SM (2007). Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates. Bioorg Med Chem 15, 6868–6875.

Kaminsky R, Zweygarth E (1989). Feeder layer-free in vitro assay for screening antitrypanosomal compounds against Trypanosoma brucei brucei and T. b. evansi. Antimicrob Agents Chemother 33, 881-885.

Kang JB, Liang NC (1997). Studies on the inhibitory effects of quercetin on the growth of HL-60 leukemic cells. Biochem Pharmacol 54, 1013-1018.

Kasamatsu T, Kohda K, Kawazoe Y (1996). Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay. Mutat Res 369, 1-6.

Keniry MA, Hollander C, Benz CC (1989). The effect of gossypol and 6 aminonicotinamide on tumor cell metabolism: a 31P-magnetic resonance spectroscopic study. Biochem Biophys Res Commun 164, 947-953.

Khafif A, Schantz SP, Chou TC, Edelstein D, Sacks PG (1998). Quantitation of chemopreventive synergism between (-)-epigallocatechin-3-gallate and curcumin in normal, premalignant and malignant human oral epithelial cells. Carcinogenesis 19, 419-424.

Khan HY, Zubair H, Ullah MF, Ahmad A, Hadi SM (2011). Oral administration of copper to rats leads to increased lymphocyte cellular DNA degradation by dietary polyphenols: implications for a cancer preventive mechanism. Biometals 24, 1169-1178.

Khan N, Mukhtar H (2008). Multitargeted therapy of cancer by green tea polyphenols. Cancer Lett 269, 269–280.

Kim HS, Bowen P, Chen L, Duncan C, Ghosh L, Sharifi R, Christov K (2003). Effects of tomato sauce consumption on apoptotic cell death in prostate benign hyperplasia and carcinoma. Nutr Cancer. 47, 40–47.

Kitada S, Kress CL, Krajewska M, Jia L, Pellecchia M, Reed JC (2008). Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048). Blood 111, 3211–3219.

Klaunig JE, Kamendulis LM (2004). The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44, 239-267.

Knobloch K, Pauli A, Iberl B, Weigand H, Weis N (1989). Antibacterial and antifungal properties of essential oil components. J Essen Oil Res 1, 119–128.

Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC (2010). Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med (Maywood) 235, 751-760.

Komatsu K, Kator K, Mitsuda Y, Mine M, Okumura Y (1994). Inhibitory effects of Rooibos tea, Aspalathus linealis, on x-ray-induced C3H10T1/2 cell transformation. Cancer Lett 77, 33– 38.

 

References

134

Komatsu K, Tauchi H, Yano N, Endo S, Matsuura S, Shoji S (1997). Inhibitory action of (-)-epigallocatechin gallate on radiation-induced mouse oncogenic transformation. Cancer Lett 112, 135–139.

Kong Q, Beel JA, Lillehei KO (2000). A threshold concept for cancer therapy. Med Hypothesis 55, 29-35.

Koo JY, Kim HJ, Jung KO, Park KY (2004). Curcumin inhibits the growth of AGS human gastric carcinoma cells in vitro and shows synergism with 5-fluorouracil. J Med Food 7, 117–121.

Kunnumakkara AB, Guha S, Krishnan S, Diagaradjane P, Gelovani J, Aggarwal BB (2007). Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer Res 67, 3853–3861.

Kuo SM (1996). Antiproliferative potency of structurally distinct dietary flavonoids on human cancer cells. Cancer Lett 110, 41-48.

Kuroda Y (1996). Bio-antimutagenic activity of green tea catechins in cultured Chinese hamster V79 cells. Mutat Res 361, 179–186.

Kuroda Y, Hara Y (1999). Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutat Res 436, 69–97.

Lau AT, Chiu JF (2006). Proteomic and biochemical analyses of in vitro carcinogen-induced lung cell transformation: synergism between arsenic and benzo[a]pyrene. Proteomics 6, 1619-1630.

Lau AT, He QY, Chiu JF (2004). A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis. Biochem J 382, 641-650.

Laughton MJ, Halliwell B, Evans PJ, Hoult JR (1989). Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Biochem Pharmacol 38, 2859-2865.

Lee BM, Park KK (2003). Beneficial and adverse effects of chemopreventive agents. Mutat Res 523-524:265-278.

Lee MR (2011). The history of Ephedra (ma-huang). J R Coll Physicians Edinb 41, 78-84.

Li A, Bandy B, Tsang SS, Davison AJ (2000). DNA-breaking versus DNA-protecting activity of four phenolic compounds in vitro. Free Rad Res 33, 551-566.

Li J, Zhang D, Wu X (2011). Synthesis and biological evaluation of novel exo-methylene cyclopentanone tetracyclic diterpenoids as antitumor agents. Bioorg Med Chem Lett 21(1), 130-132.

Li XM, Zhang TF, Sampson H, Zou ZM, Beyer K, Wen MC, Schofield B (2004). The potential use of Chinese herbal medicines in treating allergic asthma. Ann Allergy Asthma Immunol 93, 35-44.

Liang YC, Lin-Shiau SY, Chen CF, Lin JK (1999). Inhibition of cyclin-dependent kinases 2 and 4 activities as well as induction of Cdk inhibitors p21 and p27 during growth arrest of human breast carcinoma cells by (-)-epigallocatechin-3-gallate. J Cell Biochem 75, 1–12.

 

References

135

Lin TS, Schinazi R, Griffith BP, August EM, Eriksson BFH, Zheng DK, Huang L, Prusoff WH (1989). Selective inhibition of human immunodeficiency virus type 1 replication by the (-) but not the (+) enantiomer of gossypol. Antimicrob Agents Chemother 33, 2149-2151.

Lin TS, Schinazi RF, Zhu J, Birks E, Carbone R, Si Y, Wu K, Huang L, Prusoff WH (1993). Anti-HIV-1 activity and cellular pharmacology of various analogs of gossypol. Biochem Pharmacol 46, 251-255.

Linder MC (1991). In: Nutritional biochemistry and metabolism. Elsevier New York

Liu JD, Chen SH, Lin CL, Tsai SH, Liang YC (2001). Inhibition of melanoma growth and metastasis by combination with (-)-epigallocatechin-3-gallate and dacarbazine in mice. J Cell Biochem 83, 631–642.

Lobert S, Vulevic B, Correia JJ (1996). Interaction of Vinca Alkaloids with Tubulin:  A Comparison of Vinblastine, Vincristine, and Vinorelbine. Biochemistry 35, 6806–6814.

Long LH, Clement MV, Halliwell B (2000). Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin and quercitin to commonly used cell culture media. Biochem Biophys Res Commun 273, 50-53.

Long LH, Clement MV, Halliwell B (2000). Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin and quercetin to commonly used cell culture media. Biochem Biophys Res Commun 273, 50-53.

Lu HQ, Niggemann B, Zanker KS (1996). Suppression of the proliferation and migration of oncogenic ras-dependant cell lines, cultured in a three dimension collagen matrix, by flavonoid structured molecules. J Cancer Res Clin Oncol 122, 335-342.

Mahgoub AA (2003). Thymoquinone protects against experimental colitis in rats. Toxicol Lett 143, 133–143.

Mansour MA, Nagi MN, El-Khatib AS, Al-Bekairi AM (2002). Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action. Cell Biochem Funct 20, 143–151.

Mao QQ, Huang Z, Ip SP, Xian YF, Che CT (2011). Protective Effects of Piperine Against Corticosterone-Induced Neurotoxicity in PC12 Cells. Cell Mol Neurobiol [Epub ahead of print].

Margalioth EJ, Udassin R, Cohen C, Maor J, Anteby SO, Schenker JG (1987). Serum copper level in gynecologic malignancies. Am J Obstet Gynecol 157, 93–96.

Margalith P (1967). Inhibitory effect of gossypol on microorganisms. Appl Microbiol 15, 952-953.

Marsik P, Kokoska L, Landa P, Nepovim A, Soudek P, Vanek T (2005). In vitro inhibitory effects of thymol and uinines of Nigella sativa seeds on cyclooxygenase-1- and -2-catalyzed prostaglandin E2 biosyntheses. Planta Medica 71, 739–742.

McCord JM (2000). The evolution of free radicals and oxidative stress. Am J Med 108, 652-659.

 

References

136

Mehta K, Pantaziz P, Mcqueen T, Aggarwal BB (1997). Antiproliferative effect of curcumin (diferuloyl methane) against human breast tumor cell lines. Anticancer Drugs 8, 470-481.

Mendis K, Sina BJ, Marchesini P, Carter R (2001). The neglected burden of plasmodium vivax malaria. Am J Trop Med Hyg 64, 97-106.

Meng Y, Tang W, Dai Y, Wu X, Liu M, Ji Q, Ji M, Pienta K, Lawrence T, Xu L (2008). Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and Noxa. Mol Cancer Ther 7, 2192-2202.

Mi JX, Wang GF, Wang HB, Sun XQ, Ni XY, Zhang XW, Tang JM, Yang DJ (2008). Synergistic antitumoral activity and induction of apoptosis by novel pan Bcl-2 proteins inhibitor apogossypolone with adriamycin in human hepatocellular carcinoma. Acta pharmacol Sin 29, 1467-1477.

Michelitsch A, Rittmannsberger A (2003). A simple differential pulse polarographic method for the determination of thymoquinone in black seed oil. Phytochem Anal 14, 224–227.

Milner JA (2008). Nutrition and cancer: essential elements for a roadmap. Cancer Lett 269, 189–198.

Mohammad RM, Wang S, Aboukameel A, Chen B, Wu X, Chen J, Al-Khatib (2005). Preclinical studies of a nonpeptidic small-molecule inhibitor of Bcl-2 and Bcl-X(L) [(-)-gossypol] against diffuse large cell lymphoma. Mol Cancer Ther 4, 13-21.

Mohammadianpanah M, Ahmadloo N, Mozaffari MA, Mosleh-Shirazi MA, Omidvari S, Mosalaei A (2009). Primary localized stages I and II non-Hodgkin’s lymphoma of the nasopharynx: a retrospective 17-year single institutional experience. Ann hematol 88, 441-447.

Montamat EE, Burgos C, Gerez De Burgos NM, Rovai LE, Blanco A (1982). Inhibitory action of gossypol on enzymes and growth of trypanosome cruzi. Science 218, 288-289.

Moon DO, Kim MO, Choi YH, Lee HG, Kim ND, Kim GY (2008). Gossypol suppresses telomerase activity in human leukemia cells via regulating hTERT. FEBS Lett 582, 3367-3373.

Moskaug JO, Carlsen H, Myhrstad MC, Blomhoff R (2005). Polyphenols and glutathione synthesis regulation. Am J Clin Nutr 81, 277-283.

Murakami A, Ashida H, Terao J (2008). Multitargeted cancer prevention by quercetin. Cancer Lett 269, 315–325.

Muto S, Yokoi T, Gondo Y, Katsuki M, Shioyama Y, Fujita K, Kamataki T (1999). Inhibition of benzo-[a]pyrene-induced mutagenesis by (-)-epigallocatechin gallate in the lung of rpsL transgenic mice. Carcinogenesis 20, 421–424.

Nagi MN, Mansour MA (2000). Protective effect of thymoquinone against doxorubicin-induced cardiotoxicity in rats: a possible mechanism of protection. Pharmacology Research 41, 283–289.

Nakayama T, Kimura T, Kodama T, Nagata C (1983). Generation of hydrogen peroxide and superoxide anion from active metabolites of napthylamines and amino azo dyes. Carcinogenesis 4, 765-769.

References

137

Nazeem S, Azmi AS, Hanif S, Ahmad A, Mohammad RM, Hadi SM, Kumar SK (2009). Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells. Mutagenesis 24, 413–418.

Noroozi M, Angerson WJ, Leon MEJ (1998). Effects of flavonoids and vitamin C on oxidative DNA damage to lymphocytes. Am J Clin Nutr 69, 1210-1218.

Novgorodov SA, Gudz TI (1996). Permeability transition pore of the inner mitochondrial membrane can operate in two open states with different selectivities. J Bioenerg Biomembr 28, 139–146.

Oberley TD, Oberley LW (1997). Antioxidant enzyme levels in cancer. Histol Histopathol 12, 525–535.

Okuda T, Mori K, Hayatsu H (1984). Inhibitory effect of tannins on direct-acting mutagens. Chem Pharm Bull (Tokyo) 32, 3755–3758.

Okwu DE (2004). Phytochemical and vitamin content of indigenous spices of South Eastern Nigeria. J Sustain Agric Environ 6, 30-34.

Ossola B, Kaariainen TM, and Mannisto PT (2009). The multiple faces of quercetin in neuroprotection. Expert Opin Drug Saf 8, 397–409.

Parshad R, Sanford KK, Price FM, Steele VE, Tarone RE, Kelloff GJ, Boone CW (1998). Protective action of plant polyphenols on radiation induced chromatid breaks in cultured human cells. Anticancer Res 18, 3263-3266.

Peana AT, D’Aquilaa PS, Chessaa ML, Morettia MD, Serraa G, Pippiab P (2003). (−)-Linalool produces antinociception in two experimental models of pain. Eur J Pharmacol 460, 37–41.

Peng F, Lu X, Janisse J, Muzik O, Sheilds AF (2006). PET of Human Prostate Cancer Xenografts in Mice with Increased Uptake of 64CuCl2. J Nucl Med 47, 1649-1652.

Perrone A, Capasso A, Festa M, Kemertelidze E, Pizza C, Skhirtladze A, Piacente S (2012). Antiproliferative steroidal glycosides from Digitalis iliate. Fitoterapia [Epub ahead of print].

Pezzuto J (1996). Plant-derived anticancer agents. Biochem Pharmacol 53, 121-133.

Pool-Zobel BL, Guigas C, Klein R, Neudecker C, Renner HW, Schmezer P (1993). Assessment of genotoxic effects by lindane. Food Chem Toxicol 31, 271-283.

Poprawski TJ, Jones WJ (2001). Host plant effects on activity of the mitosporic fungi Beauveria bassiana and Paecilomyces fumosoroseus against two populations of Bemisia whiteflies (Homoptera: Aleyrodidae). Mycopathologia. 151, 11-20.

Pryor WA (1988). Why is hydroxyl radical the only radical that commonly binds to DNA? Hypothesis: It has rare combination of high electrophilicity, thermochemical reactivity and a mode of production near DNA. Free Radic Biol Med 4, 219– 233.

Purkis SW, Meger M, Wuttke R (2011). A review of current smoke constituent measurement activities and aspects of yield variability. Regul Toxicol Pharmacol 62, 202-213.

Qian, YP, Cai YJ, Fan GJ, Wei QY, Yang J, Zheng LF, Li XL, Fang JQ, Zhou B (2009). Antioxidant-based lead discovery for cancer chemoprevention: the case of resveratrol. J Med Chem 52, 1963-1974.

 

References

138

Quinlan GJ, Gutteridge JMC (1987). Oxygen radical damage to DNA by rifamycin SV and copper ions. Biochem Pharmacol 36, 36-39.

Raeissi SD, Guo ZY, Dobson GL, Artrusson P, Hidalgo IJ (1997). Comparison of Cyp-3a activities in a subclone of Caco-2 cells (EC-7) and human intestine. Pharm Res 14, 1019-1025.

Rahman A, Shahabuddin A, Hadi SM, Parish JH (1990). Complexes involving quercetin, DNA and Cu(II). Carcinogenesis 11, 2001–2003.

Ramanathan A, Das NP, Tan CH (1994). Effects of clinolenic acid, flavonoids and vitamins on cytotoxicity and lipid peroxidation. Free Radic Biol Med 16, 43-48.

Razakantoanina V, Nguyen Kim PP, Jaureguiberry G (2000). Antimalarial activity of new gossypol derivatives. Parasitol Res 86, 665-668.

Ricchi P, Pignata S, DiPopplo A, Memoli A, Apicelli A, Zarilli R, Acquaviva AM (1997). Effect of aspirin on cell proliferation and differentiation of colon carcinoma Caco-2 cells. Int J Cancer 73, 880-884.

Richter C, Schlegel J (1993). Mitochondrial calcium release induced by prooxidants. Toxicol Lett 67, 119–127.

Rosenberg LJ, Adlakha RC, Desai DM, Rao PN (1986). Inhibition of DNA polymerase alpha by gossypol. Biochim Biophys Acta 866, 258-267.

Royer RE, Deck LM, Campos NM, Hunsaker LA, Vander Jagt DL (1986). Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles. J Med Chem 29, 1799-1801.

Royer RE, Deck LM, Vander Jagt TJ, Martinez FJ, Mills RG, Young SA, Vander Jagt DL (1995). Synthesis and anti-HIV activity of 1,1’-dideoxygossypol and related compounds. J Med Chem 38, 2427-2432.

Royer RE, Mills RG, Deck LM, Mertz GJ, Vander Jagt DL (1991). Inhibition of human immunodeficiency virus type I replication by derivatives of gossypol. Pharmacol Res 24, 407-412.

Russo GL (2007). Ins and outs of dietary phytochemicals in cancer chemoprevention. Biochem Pharmacol 74, 533-544.

Sakagami H, Satoh K (1997). Prooxidant action of two antioxidants: ascorbic acid and gallic acid. Anticancer Res 17, 221–224.

Sakihama Y, Cohen MF, Grace SC, Yamasaki H (2002). Plant phenolic antioxidant and prooxidant activities: phenolics-induced oxidative damage mediated by metals in plants. Toxicology 177, 67–80.

Sasaki YF, Yamada H, Shimoi K, Kator K, Kinae N (1993). The clastogen-suppressing effects of green tea, Po-lei tea and Rooibos tea in CHO cells and mice. Mutat Res 286, 221–232.

Scambia G, Panici PB, Ranelletti FO, Ferradina G, De Vincenzo R, Piantelli M, Masciullo V, Bonanno G, Isola G, Mancuso S (1994a). Quercetin enhances transforming growth factor beta 1 secretion by human ovarian cancer cells. Int J Cancer 57, 211-215.

 

 

References

139

Scambia G, Ranelletti FO, Panici PB, De Vincenzo R, Bonanno G, Ferrandina G, Piantelli M, Bussa S, Rumi C, Cianfriglia M, Mancuso S (1994b). Quercetin potentiates the effect of andriamycin in a multidrug-resistant MCF-7 human breast cancer cell line: P-glycoprotein as a possible target. Cancer Chemother Pharmacol 34, 459-464.

Schiff PB, Fant J, Horwitz SB (1979). Promotion of microtubule assembly in vitro by taxol. Nature 277, 665-667.

Schneider WC (1957). Determination of nucleic acids in tissues by pentose analysis. Methods Enzymol 3, 880-884.

Schultes RE (1978). The kingdom of plants, In: WAR Thomas (Ed), Medicines from the Earth. Mc Graw Hill Book Co, New York, pp 208.

Schumacker PT (2006). Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell 10, 175–176.

Schumacker PT (2006). Reactive oxygen species in Cancer cells; Live by the sword, die by the sword. Cancer Cell 10, 175-176.

Schwarz S, Obermuller-Jevic UC, Hellmis E, Koch W, Jacobi G, Biesalski HK (2008). Lycopene inhibits disease progression in patients with benign prostate hyperplasia. J Nutr 138, 49–53.

Sen S, Sharma H, Singh N (2005). Curcumin enhances Vinorelbine mediated apoptosis in NSCLC cells by the mitochondrial pathway. Biochem Biophys Res Commun 331, 1245–1252.

Shamim U, Hanif S, Ullah MF, Azmi AS, Bhat SH, Hadi SM (2008). Plant polyphenols mobilize nuclear copper in human peripheral lymphocytes leading to oxidatively generated DNA breakage: Implications for an anticancer mechanism. Free Radic Res 42, 764-772.

Shankar S, Ganapathy S, and Srivastava RK (2007). Green tea polyphenols: biology and therapeutic implications in cancer. Front Biosci 12, 4881–4899.

Shin SS, Park D, Lee HY, Hong Y, Choi J, Oh J, Lee H, Lee HR, Kim MR, Shen ZB, Cui HH, Yoon M (2011). The herbal composition GGEx18 from Laminaria japonica, Rheum palmatum, and Ephedra sinica reduces obesity via skeletal muscle AMPK and PPARα. Pharm Biol [Epub ahead of print].

Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK (2003). In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 22, 107–113.

Si W, Gong J, Tsao R, Zhou T, Yu H, Poppe C, Johnson R, Du Z (2006). Antimicrobial activity of essential oils and structurally related synthetic food additives towards selected pathogenic and beneficial gut bacteria. J Appl Microbiol 100, 296–305.

Sikkema J, De Bont JAM, Poolman B (1994). Interactions of cyclic hydrocarbons with biological membranes. J Biol Chem 269, 8022–8028.

Simamura E, Hirai K, Shimada H, Koyama J, Niwa Y, Shimizu S (2006). Furanonaphthoquinones cause apoptosis of cancer cells by inducing the production of reactive oxygen species by the mitochondrial voltage-dependent anion channel. Cancer Biol Ther 5, 1523–1529.

Simpson JA, Narita S, Geiseg S, Gebicki S, Dean RT (1992). Long-lived reactive species on free-radical-damaged proteins. Biochem J 282, 621-624.

References

140

Singh NP, McCoy MT, Tice RR, Schneider EL (1988). A simple technique for quantification of low levels of DNA damage in individual cells. Exp Cell Res 175, 184-191.

Sreepriya M, Bali G (2006). Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced

hepatocarcinogenesis in Wistar rats. Mol Cell Biochem 284, 49–55.

Steinmetz KA, Potter JD (1996). Vegetables, fruit, and cancer prevention: a review. J Am Diet Assoc 96, 1027–1039.

Sun J, Li ZM, Hu ZY, Lin XB, Zhou NN, Xian LJ, Yang DJ, Jiang WQ (2008). ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells. Anticancer Drugs 19, 967-974.

Sun SY, Hail N Jr, Lotan R (2004). Apoptosis as a novel target for cancer chemoprevention. J Natl Cancer Inst 96, 662–672.

Surh YJ (2003). Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3, 768-780.

Surh YJ, Chun KS (2007). Cancer chemopreventive effects of curcumin. Adv Exp Med Biol 595, 149–172.

Temple NJ (2000). Antioxidants and disease: more questions than answers. Nutr Res 20, 449-459.

Terry P, Hu FB, Hansen H, Wolk A (2001). Prospective study of major dietary patterns and colorectal cancer risk in women. Am J Epidemiol 154, 1143–1149.

Thiriez C, Villafane G, Grapin F, Fenelon G, Remy P, Cesaro P (2011). Can nicotine be used medicinally in Parkinson's disease? Expert Rev Clin Pharmacol 4, 429-436.

Tice RR, Agurell E, Anderson D, Burlinson B, Hartmann A, Kobayashi H, Miyamae Y, Rojas E, Ryu JC, Sasaki YF (2000). Single cell gel electrophoresis/Comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ Mol Mutagen 35, 206–221.

Tiwari M, Kakkar P (2009). Plant derived antioxidants-geraniol and camphene protect rat alveolar macrophages against t-BHP induced oxidative stress. Toxicol In Vitro 23, 295–301.

Traina O, Cafarchia C, Capelli G, Iacobellis NS, Otranto D (2005). In vitro acaricidal activity of four monoterpenes and solvents against Otodectes cynotis (Acari: Psoroptidae). Exp Appl Acarol 37, 141–146.

Turina AV, Nolan MV, Zygadlo JA, Perillo MA (2006). Natural terpenes: self-assembly and membrane partitioning. Biophys Chem 122, 101–113.

Uddin S, Choudhry MA (1995). Quercetin a biflavonoid, inhibits the DNA synthesis of human leukemia cells. Biochem Mol Biol Int 36, 545-550.

Ueno H, Sahni MK, Segal SJ, Koide SS (1988). Interaction of gossypol with sperm macromolecules and enzymes. Contraception 37, 333-341.

 

 

References

141

Ullah MF, Ahmad A, Khan HY, Zubair H, Sarkar FH, Hadi SM (2011). The prooxidant action of dietary antioxidants leading to cellular DNA breakage and anticancer effects: implications for chemotherapeutic action against cancer. Cell Biochem Biophys [Epub ahead of print].

Ullah MF, Khan HY, Zubair H, Shamim U, Hadi SM (2011). The antioxidant ascorbic acid mobilizes nuclear copper leading to a prooxidant breakage of cellular DNA: implications for chemotherapeutic action against cancer. Cancer Chem Pharm 67, 103-110.

Ullah MF, Shamim U, Hanif S, Azmi AS, Hadi SM (2009). Cellular DNA breakage by soy isoflavone genistein and its methylated structural analogue biochanin A. Mol Nutr Food Res 53, 1376-1385.

Ultee A, Bennik MH, Moezelaar R (2002). The phenolic hydroxyl group of carvacrol is essential for action against the food-borne pathogen Bacillus cereus. Appl Environ Microbiol 68, 1561–1568.

UNESCO (1996). Culture and Health, Orientation Texts – World Decade for Cultural Development 1988 – 1997, Document CLT/DEC/PRO – 1996, Paris, pgs. 129.

UNESCO (1998). FIT/504-RAF-48 Terminal Report: Promotion of Ethnobotany and the Sustainable Use of Plant Resources in Africa, Paris, 1998, pgs. 60.

Vadehra DV, Kalla NR, Saxena M, Hashia R, Kaur P, Gupta LK (1985). Antimicrobial activity of gossypol acetic acid. IRCS Med Sci 13, 10-11.

Van Duyn MA, Pivonka E (2000). Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. J Am Diet Assoc 100, 1511–1521.

Vander Jagt DL, Deck LM, Royer RE (2000). Gossypol: prototype of inhibitors targeted to dinucleotide folds. Curr Med Chem 7, 479-498.

Venkateswaran V, Fleshner NE, Sugar LM, Klotz LH (2004). Antioxidants block prostate cancer in lady transgenic mice. Cancer Res 64, 5891–5896.

Venturi M, Hambly RJ, Glinghammer B, Rafter JJ, Rowland IR (1997). Genotoxic activity in human feacal water and the role of bile acids: a study using comet assay. Carcinogenesis 18, 2353-2359.

Vercesi AE, Kowaltowski AJ, Grijalba MT, Meinicke AR, Castilho RF (1997). The role of reactive oxygen species in mitochondrial permeability transition. Biosci Rep 17, 43–52.

Verma SP, Salamone E, Goldin B (1997). Curcumin and genistein, plant natural products, show synergistic inhibitory effects on the growth of human breast cancer MCF-7 cells induced by estrogenic pesticides. Biochem Biophys Res Commun 233, 692–696.

Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B, Williams J (1997). Cell-cycle arrest versus cell death in cancer therapy. Nat Med 3, 1034 – 1036.

Wang L, Li D, Wang C, Zhang Y, Xu J (2011). Recent progress in the development of natural ent-kaurane diterpenoids with anti-tumor activity. Mini Rev Med Chem 11, 910-919.

 

References

142

Wang X, Beckham T, Morris J, Chen F, Gangemi D (2008). Bioactivities of gossypol, 6-methoxy gossypol and 6, 6’-dimethoxy gossypol. J Agric Food Chem 56, 4393-4398.

Wang YC, Rao PN (1984). Effect of gossypol on DNA synthesis and cell cycle progression of mammalian cells in vitro. Cancer Res 44, 35-38.

Wang ZY, Huang MT, Ferraro T, Wong CQ, Lou YR, Reuhl K, latropoulos M, Yang CS, Conney AH (1992). Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res 52, 1162–1170.

Wani AA, Hadi SM (1979). Partial purification and properties of an endonuclease from germinating pea seeds specific for single-stranded DNA. Arch Biochem Biophys 196, 138–146.

Warr MR, Shore GC (2003). Small-molecule Bcl-2 antagonists as targeted therapy in oncology. Curr Oncol 15, 256-261.

Willett WC (1994). Diet and health: what should we eat? Science 254, 532-537.

Willett WC (1995). Diet, Nutrition and avoidable cancer. Environ Health Perspect 103, 165-170.

Wiseman DA, Werner SR, Crowell PL (2007). Cell cycle arrest by the isoprenoids perilly alcohol, geraniol, and farnesol is mediated by p21Cip1 and p27Kip1 in human pancreatic adenocarcinoma cells. J Pharmacol Exp Ther 320, 1163–1170.

Wollenweber E (1988). Occurrence of flavonoid aglycones in medicinal plants. Prog Clin Biol Res 280, 45-55.

Worthen DR, Ghosheh OA, Crooks PA (1998). The in vitro anti-tumor activity of some crude and purified components of blackseed Nigella sativa L. Anticancer Res 18, 1527–1532.

Wu TE, Yang CC, Chen HS (2011). Does Atropine Use Increase Intraocular Pressure in Myopic Children? Optom Vis Sci [Epub ahead of print].

Xu M, Bailey AC, Hernaez JF, Taoka CR, Schut HA, Dashwood RH (1996). Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3 methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat. Carcinogenesis 17, 1429–1434.

Xu Q, Peng X, Tian W (2003). A new strategy for synthesizing the steroids with side chains from steroidal sapogenins: synthesis of the aglycone of OSW-1 by using the intact skeleton of diosgenin. Tetrahedron Lett 44, 9375–9377.

Ye B, Aponte M, Dai Y, Li L, Ho MC, Vitonis A, Edwards D, Huang TN, Cramer DW (2007). Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer Lett 251, 43–52.

Yoganathan P (2002). Betel chewing creeps into the New World. N Z Dent J 98, 40-45.

Yoon HS, Moon SC, Kim ND, Park BS, Jeong MH, Yoo YH (2000). Genistein induces apoptosis of RPE-J cells by opening mitochondrial PTP. Biochem Biophys Res Commun 276, 151–156.

Yoshida D, Ikeda Y, Nakazawa S (1993). Quantitative analysis of copper, zinc and copper/zinc ratio in selected human brain tumors. J Neurooncol 16, 109–115.

References

143

Zhan Y, Jia G, Wu D, Xu Y, Xu L (2009). Design and Synthesis of a Gossypol Derivative with Improved Antitumor Activities. Arch Pharm Chem Life Sci 342, 223 – 229.

Zhang L, Jiang H, Cao X, Zhao H, Wang F, Cui Y, Jiang B (2009). Chiral gossypol derivatives: Evaluation of their anticancer activity and molecular modeling. Eur J Med Chem 44, 3961–3972.

Zhang M, Liu H, Guo R, Ling Y, Wu X, Li B, Roller PP, Wang S, Yang D (2003). Molecular mechanism of gossypol-induced cell growth inhibition and cell death of HT-29 human colon carcinoma cells. Biochem Pharmacol 66, 93-103.

Zheng LF, Wei QY, Cai YJ, Fang JG, Zhou B, Yang L, Liu ZL (2006). DNA damage induced by resveratrol and its synthetic analogues in the presence of Cu (II) ions: mechanism and structure–activity relationship. Free Radic Biol Med 41, 1807–1816.

Ziegler J, Facchini PJ, Geissler R, Schmidt J, Ammer C, Kramell R, Voigtlander S, Gesell A, Pienkny S, Brandt W (2009). Evolution of morphine biosynthesis in opium poppy. Phytochemistry 70, 1696-1707.