Realistic modelingthe cerebellar cortex

Sergio Solinas, Egidio D’AngeloUniversity of PaviaIRCCS C. Mondino

Alghero 13-15 May 2013

OPEN SOURCE BRAIN

1958

OSB website

“a lattice” 55 years later

Parasagittal organizationGolgi cell axon

Barmack & Yakhnitsa J. Neurosci. 2008

Parasagittal organizationMossy fiber branching

Wu et al. J. Comparative Neurology 1999

Lattice arrangement

Pellionisz & Szentágothai Brain Research 1973

Purkinje celldendritic fields

Stellate cellaxonal field

Golgi cellaxonal field

Parallelfibers

Golgi celldendritic field

Network picture from otto

Convey channel:

Cerebral cortex

Sensory nuclei

Input of the cerebellar cortex

Spot scale 200 µm

Center/ surround effect

Parallelf fiber scale 2 mm: Lateral inhibition

Collaborative developmentSheffield: tests and analysis proceduresAmrita: LFP reconstruction &

Multicompartmenteal GRC model

Field Programmable Gate Array (FPGA)PhD Thesis Alessandra Majani

NEURON simulator

Hart beat discrimination

F1 engine monitor

FPGA simulatorSingle compartment model of Cerebellar granule cell(D’Angelo et al. 2001, Solinas et al .2010)

FPGA simulator

Architecture N° CELLs FPGA complexity Expandable

SOFTWARE 100 LOW YES

HARDWARE 1 300 LOW NO

HARDWARE 2 150 HIGH LIMITS

HARDWARE 3 2500-5000 MEAN YES

HARDWARE 4 50000-100000 MEAN LIMITS

Neurophysiology Lab in PaviaBrain Connectivity Center IRCCS C. Mondino

Egidio D’AngeloFrancesca PrestoriLisa MapelliDaniela Gandolfi (Modena)Jonathan Mapelli (Modena)Francesca LocatelliLuigi CongiRamakrishnan K. B.Licia de ProprisMartina SgrittaMartina PaganiPaolo Pozzi

Jesus GarridoStefano MasoliSathyaa SubramaniyamTimoteo ColnaghiFulvia PalesiGloria CastellazziJessica MonacoStefano CasaliAlessandra MajaniIrene SolinasLeda Ruggeri