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Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen, Stefan Duhr, William Seibel, Matthew Wortman, Yi Zheng Chemistry & Biology Volume 19, Issue 6, Pages 699-710 (June 2012) DOI: 10.1016/j.chembiol.2012.05.009 Copyright © 2012 Elsevier Ltd Terms and Conditions

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

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Figure 2 Chemistry & Biology , DOI: ( /j.chembiol ) Copyright © 2012 Elsevier Ltd Terms and Conditions Terms and Conditions

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Page 1: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases

Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen, Stefan Duhr, William Seibel, Matthew Wortman, Yi Zheng

Chemistry & Biology Volume 19, Issue 6, Pages 699-710 (June 2012)

DOI: 10.1016/j.chembiol.2012.05.009

Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 2: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 1

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 3: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 2

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 4: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 3

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 5: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 4

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 6: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 5

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 7: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 6

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

Page 8: Rational Design of Small Molecule Inhibitors Targeting RhoA Subfamily Rho GTPases Xun Shang, Fillipo Marchioni, Nisha Sipes, Chris R. Evelyn, Moran Jerabek-Willemsen,

Figure 7

Chemistry & Biology 2012 19, 699-710DOI: (10.1016/j.chembiol.2012.05.009) Copyright © 2012 Elsevier Ltd Terms and Conditions

http://www.elsevier.com/termsandconditions

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