1
q{°ª]ªz`â Division of Organogenesis and Regeneration º¶½}!pRh¤°ª(]ª Á˦¨Õ Ìb -Q¶½-ã$¥ÈÏ °ªG2>8F(X]ªG2> 8FÁËÌ·Å)+êÆÄi(ȸvÈ.ë°®G2>8FÕ láTyÁËÂÇq{WUKCJ|é-Ý/wÔ±¶½-ß&$ ì í ÁËmÜ©u(áTy°§@9OMS£±V-g+ ÁË`i¦-b±v[aÚ-'ÁË-ª%_+* $§Ù! :/K4;IBL5HEM5'n",æ±j¯- Ó¡´,$º!D07-«²ÎÁË*ÈÁË#: /K4;IBL5HEM5-Ö%òÎÁË 2 ¼çÛ^ry-Z+ ²Î ÁË-ÈÁËÚ-'ÁË ê iHep ÁËë#µvi+f$ êSekiya and Suzuki, Nature, 2011ë$¹¾ÈÁ˵נ-t³*¶½ D07²ÎÁË(A;Ò¿\²ÁË 4 ¼çÛ^ry-Z+µ ÍcèÁËêiFIPÁËë#àoÛ-×+'f$êMiura and Suzuki, Cell Stem Cell, 2017ë,*!ÁË»j¯(eѶ½`â «,+,$ È\É¿ ÈÁË ÈcèÁË Notch65=J °ªN]ª ÆÄÐÁË Û^ry êHnf4a & Foxa3ë ×ÈÁËêiHepÁËë :/K4;IBL5HEM5 Direct reprogramming Sekiya and Suzuki, Nature, 2011 Miura and Suzuki, Front Cell Dev Biol, 2014 äÞIBL5HEM5 Disease-related cellular reprogramming È\É¿. ¬¦ È¢êÁÉ¿kë å~°.d Notch65=J É¿ÀØÁË Sekiya and Suzuki, Am J Pathol, 2014 Sekiya et al., Stem Cell Reports, 2016 Onoyama et al., J Clin Invest, 2011 Sekiya and Suzuki, J Clin Invest, 2012 Terada et al., Sci Rep, 2016 Suzuki et al., Development, 2003 Takashima et al., Hepatology, 2015 Takashima et al., Hepatology, 2016 Sekiya and Suzuki, PNAS, 2011 Miura and Suzuki, Am J Pathol, 2020 Suzuki et al., Hepatology, 2000 & 2008 Suzuki et al., J Cell Biol, 2002 Suzuki et al., Development, 2008 Miura and Suzuki, Cell Stem Cell, 2017 D07 Û^ry êHnf4a, Foxa3, Gata6, Cdx2ë ×ÍcèÁË êiFIPÁËë ×ÍÁË êiISÁËë UsÍP²1J3?/< ÊYsÍP²1J3?/< ÍP²ÂÇ A; ×ÍcèÁË êiFIPÁËë Û^ry êHNF4A, FOXA3, GATA6, CDX2ë Ò¿\²ÁË xÍP²ÂÇ » » :/K4;IBL5HEM5 Direct reprogramming

q{°ª]ªz`â Division of Organogenesis and Regeneration · 2020-05-07 · q{°ª]ªz`â Division of Organogenesis and Regeneration º ¶½} !pRh¤ °ª ( ]ª ÁË ¦¨Õ Ìb -Q ¶½-

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Page 1: q{°ª]ªz`â Division of Organogenesis and Regeneration · 2020-05-07 · q{°ª]ªz`â Division of Organogenesis and Regeneration º ¶½} !pRh¤ °ª ( ]ª ÁË ¦¨Õ Ìb -Q ¶½-

Division of Organogenesis and Regeneration

/

2iHep

Sekiya and Suzuki, Nature, 20114

iFIP Miura and Suzuki,Cell Stem Cell, 2017

Notch

Hnf4a & Foxa3

iHep

Direct reprogramming

Sekiya and Suzuki, Nature, 2011Miura and Suzuki, Front Cell Dev Biol, 2014

Disease-related cellular reprogramming

Notch

Sekiya and Suzuki, Am J Pathol, 2014Sekiya et al., Stem Cell Reports, 2016

Onoyama et al., J Clin Invest, 2011Sekiya and Suzuki, J Clin Invest, 2012Terada et al., Sci Rep, 2016

Suzuki et al., Development, 2003Takashima et al., Hepatology, 2015Takashima et al., Hepatology, 2016

Sekiya and Suzuki, PNAS, 2011Miura and Suzuki, Am J Pathol, 2020

Suzuki et al., Hepatology, 2000 & 2008Suzuki et al., J Cell Biol, 2002Suzuki et al., Development, 2008

Miura and Suzuki, Cell Stem Cell, 2017

Hnf4a, Foxa3, Gata6, Cdx2

iFIP iIS

iFIP

HNF4A, FOXA3, GATA6, CDX2

Direct reprogramming