Question :

1. It was very interesting that on the result of this journal, it said that there were no statistically significant on fat distribution on women with preeclampsia and control group, can you explained why?

2. On this journal, it said that there were no difference in insulin sensitivity between both group, can the presentant explained how the researcher conclude that?

3. What are the limitation of this study, and can this design of study done in our place?4. On the conclusion of this journal, it said that women with prior history of preeclampsia will

have a worse prognosis of having higher risk factor of cardiovascular disease, what we should do as an obgyn to prevent the poor maternal prognosis?

Answer :

1. On the table 2, it was clearly said that there were no statistically different between women with prior preeclampsia and control group, but in the table 3, the sub-group of mild preeclampsia tends to have higher fat distribution compared to the other group, it because of the matching method of this study that sample must have BMI range no more than 2,5 point, so the result will be close that despite the other mechanism of fat distribution and fact that familial genetics history were play role in table 3 result.

2. Insulin sensitivity were calculated by fasting plasma glucose and fasting insulin, this research method to measure the insulin sensitivity were using Homeostasis Model Assesment – Insulin Resistance and Quantitative Insulin Sensitivity Check Index, which is explained on the other study by Hutch et al, by calculating the fasting plasma glucose and fasting insulin that reflect hepatic insulin sensitivity.

3. The limitation of this study were the researcher didnt take family history in the exclution criteria, and also race weren’t matched between the groups, an another limitation of this study, the cross sectional design cannot address whether the women’s baseline risk factors increase their condition to have cardiovascular disease.This study also can be done in our place, but the disadvantage are it require a huge sample and it’s relatively expensive.

4. On the result of this journal it was said that women with preeclampsia will have a worse prognosis of risk factor to cardiovascular disease, but in the other similar study it was said that the risk factor of cardiovascular disease is increase in following 20 years, so what we do as an obgyn is pursue the women with prior preeclampsia to have a healthy lifestyle to reduce the risk factor of having cardiovascular disease.