2003 Quinoline derivatives

Quinoline derivativesR 0410 Quinoline-Carboxylic Acids Are Potent Inhibitors that Inhibit the Binding of

Insulin-Like Growth Factor (IGF) to IGF-Binding Proteins. — The preparation of a series of 4-benzylquinolines (VI) (7 examples) based on heating aniline derivatives (I) with acetylenedicarboxylate (II) and their evaluation as inhibitors of title receptors is presented (no yields given). — (CHEN*, C.; et al.; Bioorg. Med. Chem. Lett. 13 (2003) 11, 1931-1934; Neurocrine Biosci., Inc., San Diego, CA 92121, USA; Eng.) — M. Schroeter

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