CURRICULUM VITAE The Johns Hopkins University

Andrew P. Feinberg, M.D., M.P.H. 2/26/2019 DEMOGRAPHIC AND PERSONAL INFORMATION Current Appointments Bloomberg Distinguished Professor, Johns Hopkins University School of Medicine, Whiting School of Engineering, and

Johns Hopkins Bloomberg School of Public Health King Fahd Professor of Medicine, Biomedical Engineering, Mental Health, Oncology, Biostatistics, Molecular Biology &

Genetics, and Psychiatry & Behavioral Sciences Inaugural Daniel Coit Gilman Scholar, Johns Hopkins University Director, Center for Epigenetics, Johns Hopkins Institute for Basic Biomedical Sciences Chief, Division of Molecular Medicine, Department of Medicine Foreign Adjunct Professor, Karolinska Institute, Sweden Contact Information 855 N. Wolfe St. Room 570 Baltimore, MD 21205 afeinberg@jhu.edu Website: http://feinberglab.jhu.edu Education and Training Undergraduate 1966-1969 Susquehanna Township Senior High School, Harrisburg, Pennsylvania 1969-1971 Yale University, New Haven, Connecticut (Directed Studies Intensive Program) 1971-1973 Johns Hopkins University School of Medicine (Accelerated Program), Biology, B.A.

Doctoral/graduate 1971-1976 Johns Hopkins University School of Medicine (Accelerated Program), Medicine, M.D. 1980-1981 Johns Hopkins University School of Hygiene and Public Health, Environmental Health, M.P.H.

Postdoctoral 1976-1977 Intern, Medicine, Hospital of the University of Pennsylvania 1977-1979 Research Fellow, Neurosciences, University of California, San Diego (with Samuel Barondes) 1981-1983 Clinical and Research Fellow, Medicine (Medical Genetics with Victor McKusick) and Oncology

(Cancer Genetics with Bert Vogelstein), Johns Hopkins University School of Medicine Professional Experience 1979-1980 Instructor, Department of Medicine, Johns Hopkins Hospital 1983-1986 Assistant Professor of Oncology and Medicine, Johns Hopkins University School of Medicine 1986-1989 Assistant Professor of Internal Medicine and Human Genetics, University of Michigan Medical

School 1986-1989 Assistant Investigator, Howard Hughes Medical Institute 1986-1994 Member, Graduate Program in Cellular and Molecular Biology, University of Michigan Medical

School 1989-1994 Associate Professor with Tenure, University of Michigan Medical School 1989-1994 Associate Investigator, Howard Hughes Medical Institute 1994-Present King Fahd Professor of Molecular Medicine, Department of Medicine, Johns Hopkins University

School of Medicine 1994-Present Institute of Genetic Medicine, Johns Hopkins University School of Medicine

1994-Present Joint Appointment in Molecular Biology & Genetics 1994-Present Professor of Oncology 1994-Present Member, Graduate Program in Human Genetics, Johns Hopkins University 1994-Present Member, Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School

of Medicine 1995-Present Member, Graduate Program in Biochemistry, Cellular & Molecular Biology, Johns Hopkins

University School of Medicine 2002-2005 Director, Epigenetics Unit, Department of Medicine, Johns Hopkins University School of Medicine 2004-Present Director, Johns Hopkins Genome Center in Epigenetics, Johns Hopkins University School of

Medicine 2005-Present Chief, Division of Molecular Medicine, Department of Medicine, Johns Hopkins University School

of Medicine 2006-Present Director, Center for Epigenetics, Institute for Basic Biomedical Sciences, Johns Hopkins University

School of Medicine 2007-Present Adjunct Professor in Epigenetics, Karolinska Institute, Sweden 2010-Present Professor of Biostatistics and Psychiatry & Behavioral Sciences 2014-2017 Presidential Scholar, Dana-Farber Cancer Institute, Boston, MA 2015-Present Bloomberg Distinguished Professor of Medicine (School of Medicine), Biomedical Engineering

(Whiting School of Engineering), and Mental Health (Bloomberg School of Public Health) RECOGNITION

Awards, Honors

1969-1971 Directed Studies, Yale University Honors Program 1973 General Honors, Johns Hopkins University 1973 NATO Fellow, Advanced Study Institute on the Computer Representation and Manipulation of

Chemical Information 1973 Phi Beta Kappa 1976 Johns Hopkins Medical Society Research Award 1981 Delta Omega, National Public Health Honorary Society 1983 Johns Hopkins University School of Medicine Award for Postdoctoral Investigation 1984-1986 John A. and George L. Hartford Fellowship 1987 Fellow, American College of Physicians 1987 Central Society for Clinical Research 1990 American Society for Clinical Investigation 1992 American College of Medical Genetics, Founding Fellow 1993 Science Citation Classic, Institute for Scientific Information (random priming, most cited research

article since 1980) 1995 Association of American Physicians 1997 Interurban Clinical Club 1999 Cover Honoree, Cancer Research 1999 Dean’s Lecture, Johns Hopkins University School of Medicine 2000 Dean’s Lecture, University of Kentucky School of Medicine 2001 ISI, Most Cited Authors List (Top 0.1%) 2001 MERIT Award, National Cancer Institute 2001 Odyssey Distinguished Lecturer Award, M.D. Anderson Cancer Center, University of Texas 2004 Tovi Comet-Walerstein Award for Cancer Research, Bar-Ilan University 2007 Doctor of Philosophy (Honoris Causa), Uppsala University, Sweden 2007 President’s Diversity Recognition Award, Johns Hopkins University 2007 Tsung Hsien and Shu Yung Wu Lecture, Univ. of Michigan Medical School 2007 Elected Member, Institute of Medicine of the National Academy of Sciences 2009 Jacob and Marcus Wallenberg Fellow, Royal Swedish Academy of Sciences, Stockholm, Sweden 2008 Susan Swerling Memorial Lecture, Harvard University 2009 Karolinska Research Lecture, Nobel Assembly, Stockholm, Sweden 2009 Elected Fellow, American Academy of Arts and Sciences 2010 Doctor of Medicine (Honoris Causa), Karolinska Institutet, Sweden

2011 Feodor Lynen Medal 2011 Inaugural Daniel Coit Gilman Scholar of Johns Hopkins University 2011 Bernard Langer Lecture in Health Sciences, University of Toronto 2011 NIH Director’s Pioneer Award 2011 Elected Fellow, American Association for the Advancement of Science 2011 Discovery Lecturer, Vanderbilt University 2013 Baruch Spinoza Chair, University of Amsterdam 2013 Graziella Persico Lecturer, FEBS 2014 Lineberger Lecturer, University of North Carolina Cancer Center 2014 Inaugural NIH Director’s Lecture, 2014 2014-2018 National Advisory Environmental Health Sciences Council, NIH 2015 Keynote Lecture, Marabou Foundation Symposium, Stockholm 2015 Klaus Hofmann Lecture, University of Pittsburgh 2016 Doctor of Philosophy (Honoris Causa), University of Amsterdam 2017 Gould Lecture, Rutgers University 2017 Award for Excellence, Association for Molecular Pathology

RESEARCH ACTIVITIES Research Focus

I have led pioneering work in several areas. These include new molecular tools such as random priming (in Nature’s top 100 papers of all time) and high-throughput array based methods for DNA methylation, as well as new biological insights into development and disease. I discovered altered DNA methylation in human cancer, human imprinted genes, the role of aberrant imprinting in cancer risk, and the role of large-scale chromatin LOCKs in normal development and cancer, as well as large hypomethylated blocks through the first whole genome bisulfite sequencing of human cancers. As Director of the NIH-funded Center of Excellence in Genome Sciences in Epigenetics, I led for 10 years a highly integrated team of investigators to develop new technology to study genome-wide epigenetics and discover its role of epigenetics in common human disease. Under an NIH Director's Pioneer Award, I have pursued a new idea that genetic variants, in evolution or in cancer, could lead to increased epigenetic plasticity, enhancing survival in a changing environment. Direct evidence for this idea comes from our recent demonstration that pancreatic cancer metastasis is driven by stochastic increased epigenetic plasticity rather than metastasis-specific mutations. We have recently defined the information theoretic properties of the epigenome in development and cancer, allowing us to identify the specific genes and mediators of entropy in biology. Inventions, Patents, Copyrights

1983 Random priming (no patent filed by University), commercial value ~$200M 1991 DNA Superfragment Cloning, Patent No. 5,240,840 1994 Method for Purifying Chromosomes and Hybrid Muntjac Cell Lines Containing Foreign

Chromosomes, Patent No. 5,635,376. 1998 Methods and Kits for Diagnosing and Determination of the Predisposition for Diseases, Patent No.

6,235,474. 2001 Methods for Assaying Gene Imprinting and Methylated CpG Islands. Patent No. 6,960,434. 2005 Gene Imprinting and Methylated CpG Islands. Patent No. 7,488,815. 2003 Methods for Identifying Cancer Risk. Patent No. 7,611,870 2008 Methods for Identifying Cancer Risk Using CpG Island Shores, Patent 12/625,240 2011 Epigenetic Antiprofiling in Human Cancer, Pending, 20130296182 2012 Detecting and Sorting Methylated DNA Using a Synthetic Nanopore, Patent No. 8,394,584 2018 Method for Detecting Cancer Through Generalized Loss of Stability of Epigenetic Domains,

European Patent No. EP2707506B1, US Patent Pending.

ORGANIZATIONAL ACTIVITIES

Editorial Board appointments

1996-2010 Associate Editor, Cancer Research 1996-2004 Associate Editor, International Journal of Oncology 1997-2001 Associate Editor, American Journal of Human Genetics 1998-2001 Associate Editor, Encyclopedia of Molecular Oncology, Springer-Verlag 2002-Present 2005-2010

Editorial Board, Cancer Cell Editorial Board, Genome Research

2008-Present Editorial Board, Epigenetics and Chromatin 2017-Present Editorial Board, Journal of Clinical Investigation

National/International Activities

1986-1987 Program Committee, Gordon Research Conference on Cancer 1990-1991 Program Committee, American Association for Cancer Research 1991-1995 Biology Research Steering Committee, Children's Cancer Group 1993-1997 Community Editor for Chromosome 11, The Human Genome Organization 1994-1995 Chairman, Symposium on Genomic Imprinting, American Association for Cancer

Research Annual Meeting 1997-1998 Program Committee, American Association for Cancer Research 1998-2001 Editorial Committee, American Society of Human Genetics 1999-Present National Wilms Tumor Study Group Steering Committee 2001-Present Kidney Tumor Disease Steering Committee, Children’s Oncology Group 2002-2003 Co-Chair, NIH International Conference on Epigenetic Mechanisms of Human Disease 2003-2004 Organizing Committee, Nobel Symposium on Epigenetics 2004-2005 Co-Chair, NCI Director's Think Tank on Epigenetics 2005-2007 Co-Chair, NCI Workshop on Defining the Epigenome 2007-2008 Member, NIH Directors’ Workshop on an Epigenetics Roadmap 2007-2010 Scientific Advisory Board, HEROIC European Epigenetics Program 2007-2008 Co-Chair, Keystone Symposium on Cancer Genomics and Epigenomics 2010-2015 Co-Chair, Wellcome Trust Symposium on Epigenomics of Disease 2014 Scientific Advisory Board, Victor Chang Research Institute, Sydney, Australia 2016-2017 National Academies Review Committee for NASA Human Health Risks 2019-Present Scientific Advisory Committee, Radiation Effects Research Foundation of the US and

Japanese governments

NIH Study Sections and Councils

1987, 1990, 1992 NIH Ad Hoc Advisory Committees 1990 American Cancer Society, DPT Study Section, Ad Hoc Member 1990-1992 NIH Pathology B Study Section 1994 NIH Chemical Pathology Study Section, Ad Hoc Member 1994-1996 Molecular Genetics Study Section, Army Breast Cancer Initiative 1996 Intramural Site Visit Committee, NICHD 1999-2003 NIH Pathology B Study Section, Charter Member 2002-2003 NIH National Human Genome Research Institute, CEGS Review Panel, ENCODE

Review Panel, Ad Hoc Member 2003-2005 NIH Cancer Genetics Study Section, Charter Member 2005-2007 Grants Review Working Group, California Institute for Regenerative Medicine

2007-2008 NIH Genetics of Health and Disease, Ad Hoc Member and Chair, Special Emphasis

Panel 2008-2013 Scientific Advisory Board, Autism Speaks Foundation 2009-2014 College of CSR Reviewers (senior trans-NIH grant review board), NIH

2014-2018 Member, National Advisory Council on Environmental Health Sciences 2018-Present Member, NIH Council of Councils

PUBLICATIONS Original Research 1. Feinberg AP. Polyhedra, pentagrams and Plato. Fibonacci Quarterly 10:435-437, 1972. 2. Feinberg AP and Snyder SH. Phenothiazine drugs: Structure-activity relationships explained by a conformation that

mimics dopamine. Proceedings of the National Academy of Sciences USA 72:1899-1903, 1975. 3. Feinberg AP, Creese I, and Snyder SH. The opiate receptor: A model explaining structure-activity relationships of

opiate agonists and antagonists. Proceedings of the National Academy of Sciences USA 73:4215-4219, 1976. 4. Creese I, Feinberg AP, and Snyder SH. Butyrophenone influences on the opiate receptor. European Journal of

Pharmacology 36:231-235, 1976. 5. Feinberg AP and Leahy W. Infantile spasms: Case report of sex-linked inheritance. Developmental Medicine and Child

Neurology 19:524-526, 1977. 6. Feinberg AP, Springer W, and Barondes SH. Segregation of pre-stalk and pre-spore cells of Dictyostelium discoideum:

Observations consistent with selective cell cohesion. Proceedings of the National Academy of Sciences USA 76:3977-3981, 1979.

7. Feinberg AP and Coffey DS. Organ site specificity for cancer in chromosomal instability disorders. Cancer Research

42:3252-3254, 1982. 8. Feinberg AP and Vogelstein B. Hypomethylation distinguishes genes of some human cancer from their normal

counterparts. Nature 301:89-92, 1983. 9. Feinberg AP and Vogelstein B. Hypomethylation of ras oncogenes in primary human cancers. Biochemical and

Biophysical Research Communication 111:47-54, 1983. 10. Feinberg AP, Vogelstein B, Droller MJ, Baylin SB, and Nelkin BD. Mutation affecting the 12th amino acid of the c-

Ha-ras oncogene product occurs infrequently in human cancer. Science 220:1175-1177, 1983. 11. Feinberg AP and Vogelstein B. A technique for radiolabeling DNA restriction endonuclease fragments to high

specific activity. Analytical Biochemistry 132:6-13, 1983. 12. Feinberg AP and Vogelstein B. Addendum: A technique for radiolabeling DNA restriction endonuclease fragments

to high specific activity. Analytical Biochemistry 137:266-267, 1984. 13. Fearon E, Vogelstein B, and Feinberg AP. Somatic deletion and duplication of genes on chromosome 11 in Wilms

tumors. Nature 309:176-178, 1984. 14. Vogelstein B, Fearon E, Hamilton SR, and Feinberg AP. Use of restriction fragment length polymorphisms to

determine the clonal origin of human tumors. Science 227:642-645, 1985. 15. Goelz SE, Vogelstein B, Hamilton SR, and Feinberg AP. Hypomethylation of DNA from benign and malignant

human colon neoplasms. Science 228:187-190, 1985. 16. Fearon E, Feinberg AP, Hamilton SR, and Vogelstein B. Loss of genes on the short arm of chromosome 11p in

bladder cancer. Nature 318:377-380, 1985.

17. Trent J, Meltzer P, Rosenblum M, Harsh G, Kinzler K, Mashal R, Feinberg AP, and Vogelstein B. Evidence for rearrangement, amplification, and expression of c-myc in a human glioblastoma. Proceedings of the National Academy of Sciences USA 83:470-473, 1986.

18. Feinberg AP, Gehrke CW, Kuo KC, and Ehrlich M. Reduced genomic 5-methylcytosine content in human colonic

neoplasia. Cancer Research 48:1159-1161, 1988. 19. Law DJ, Olschwang S, Monpezat J-P, Lefrancois D, Jagelman D, Petrelli N, Thomas G, and Feinberg AP. Concerted

nonsyntenic allelic loss in human colorectal carcinoma. Science 241:961-965, 1988. 20. Rainier S and Feinberg AP. Capture and characterization of 5-aza-2'-deoxycytidine-treated C3H 10T1/2 cells prior to

transformation. Proceedings of the National Academy of Sciences USA 85:6384-6388, 1988. 21. Reeve AE, Sih S, Raizis A, and Feinberg AP. Loss of allelic heterozygosity at a second locus on chromosome 11 in

sporadic Wilms tumor. Molecular and Cellular Biology 9:1799-1803, 1989. 22. Ping AJ, Reeve AE, Law DJ, Young MR, Boehnke M, and Feinberg AP. Genetic linkage of Beckwith-Wiedemann

syndrome to 11p15. American Journal of Human Genetics 44:720-723, 1989. 23. Delattre O. Olschwang S, Law DJ, Melot T, Remvikos Y, Salmon RJ, Sastre X, Validire P, Feinberg AP, and Thomas

G. Multiple genetic alterations distinguish distal from proximal colorectal cancer. Lancet 2:353-356, 1989. 24. Bonetta L, Kuehn SE, Huang A, Law DJ, Kalikin LM, Koi M, Reeve AE, Brownstein BH, Yeger H, Williams BRG,

and Feinberg AP. Wilms tumor locus on 11p13 defined by multiple CpG island-associated transcripts. Science 250:994-997, 1990.

25. Huang A, Campbell CE, Bonetta L, McAndrews-Hill MS, Chilton-MacNeill S, Coppes MJ, Law DJ, Feinberg AP,

Yeger H, and Williams BRG. Tissue, developmental and tumor-specific expression of divergent transcripts implicated in Wilms tumor. Science 250:991-994, 1990.

26. Upadhyaya G, Guba SC, Emerson SG, Sih SA, Feinberg AP, Talpaz M, Kantarjian HM, and Deisseroth AB.

Interferon-alpha restores the deficient expression of the cytoadhesion molecule LFA-3 by chronic myelogenous leukemia progenitor cells. Journal of Clinical Investigation 88:1281-1286, 1991.

27. Claxton D, Suh S-P, Filaccio M, Ellerson D, Gaozza E, Andersson B, Brenner M, Reading C, Feinberg A, Moen R,

Belmont J, Moore K, Talpaz M, Kantarjian H, and Deisseroth A. Molecular analysis of retroviral transduction in chronic myelogenous leukemia. Human Gene Therapy 2:317-321, 1991.

28. Maw MA, Grundy PE, Millow LJ, Eccles MR, Dunn RS, Smith PJ, Feinberg AP, Law DJ, Paterson MC, Telzerow

PE, Callen DF, Thompson AD, Richards RI, and Reeve AE. A third Wilms tumor locus on chromosome 16q. Cancer Research 52:3094-3098, 1992.

29. Feinberg AP, Johnson LA, Law DJ, Kuehn SE, Steenman M, Williams BRG, Thomas G, Boland CR, Rainier S, and

Koi M. Multiple tumor suppressor genes in multistep carcinogenesis. Tohoku Journal of Experimental Medicine 168:149-152, 1992.

30. Koi M, Johnson LA, and Feinberg AP. A novel general strategy for cloning tumor suppressor genes using radiation-

reduced chromosomal superfragments. Tohoku Journal of Experimental Medicine 168:167-168, 1992. 31. Koi M, Johnson LA, Kalikin LM, Little PFR, Nakamura Y, and Feinberg AP. Tumor cell growth arrest caused by

subchromosomal transferable DNA fragments from chromosome 11. Science 260:361-364, 1993. 32. Rainier S, Johnson LA, Dobry CJ, Ping AJ, Grundy PE and Feinberg AP. Relaxation of imprinted genes in human

cancer. Nature 362:747-749, 1993. 33. Feinberg AP. Genomic imprinting and gene activation in cancer. Nature Genetics 4:110-113, 1993.

34. Rainier S, Dobry CJ, Ping AJ, and Feinberg AP. Transcribed dinucleotide repeat polymorphism in the human IGF2 gene on chromosome 11. Human Molecular Genetics 3:386, 1994.

35. Rainier S and Feinberg AP. Genomic imprinting, DNA methylation, and cancer. Journal of the National Cancer

Institute 86:753-759, 1994. 36. Lee J-Y, Koi M, Stanbridge EJ, Oshimura M, Kumamoto AT, Feinberg AP. Simple purification of human

chromosomes to homogeneity using Muntjac hybrid cells. Nature Genetics 7:29-33, 1994. 37. Steenman M, Rainier S, Dobry CJ, Grundy P, Horon IL, Feinberg AP. Loss of imprinting of IGF2 in linked to

reduced expression and abnormal methylation of H19 in Wilms tumour. Nature Genetics 7:433-439, 1994. 38. Mannens M1, Hoovers JM, Redeker E, Verjaal M, Feinberg AP, Little P, Boavida M, Coad N, Steenman M, Bliek J,

Feinberg AP. Parental imprinting of human chromosome region 11p15.3-pter involved in the Beckwith-Wiedemann syndrome and various human neoplasia. European Journal of Human Genetics 2:3-23, 1994.

39. Bestor T, Chandler V, and Feinberg AP. Epigenetic effects in eukaryotic gene expression. Developmental Genetics

15:458-462, 1994. 40. Boland CR, Sato J, Appelman HD, Bresalier RS, and Feinberg AP. Microallelotyping defines the sequence and tempo

of allelic losses at tumour suppressor gene loci during colorectal cancer progression. Nature Medicine 1:902-909, 1995.

41. Rainier S, Dobry C, Feinberg AP. Loss of Imprinting in Hepatoblastoma. Cancer Research 55:1836-1838, 1995. 42. Hoovers JMN, Kalikin LM, Johnson LA, Alders M, Redeker B, Law DJ, Bliek J, Steenman M, Benedict M, Wiegant J,

Lengauer C, Taillon-Miller P, Schlessinger D, Edwards MC, Elledge SJ, Ivens A, Westerveld A, Little P, Mannens M, Feinberg AP. Multiple genetic loci within 11p15 defined by Beckwith-Wiedemann syndrome rearrangement breakpoints and subchromosomal transferable fragments. Proceedings of the National Academy of Sciences USA 92:12456-12460, 1995.

43. Nakamura T, Largaespada DA, Lee MP, Johnson LA, Ohyashiki K, Toyama K, Chen SJ, Willman CL, Chen IM,

Feinberg AP, Jenkins NA, Copeland NG, and Shaughnessy JD Jr. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia. Nature Genetics 12:154-158, 1996.

44. Matsuoka S, Thompson JS, Edwards MC, Barletta JM, Grundy P, Kalikin LM, Harper JW, Elledge SJ, and Feinberg

AP. Imprinting of the gene encoding a human cyclin-dependent kinase inhibitor, p57KIP2, on chromosome 11p15. Proceedings of the National Academy of Sciences USA 93:3026-3030, 1996.

45. Lee PJ, Washer LL, Law DJ, Boland CR, Horon IL, and Feinberg AP. Limited upregulation of DNA

methyltransferase in human colon cancer reflecting increased cell proliferation. Proceedings of the National Academy of Sciences USA 93:10366-10370, 1996.

46. Hu RJ, Lee MP, Johnson LA, and Feinberg AP. A novel human homologue of yeast nucleosome assembly protein 65

kb centromeric to the p57KIP2 gene is biallelically expressed in fetal and adult tissues. Human Molecular Genetics 5:1743-1748, 1996.

47. Choi Y-C, Gu W, Hecht NB, Feinberg AP, and Chae C-B. Molecular cloning of mouse somatic and testis-specific

H2B histone genes containing a methylated CpG island. DNA and Cell Biology 15:495-504, 1996. 48. Thompson JS, Reese KJ, DeBaun MR, Perlman EJ, and Feinberg AP. Reduced expression of the cyclin-dependent

kinase inhibitor gene p57KIP2 in Wilms tumor. Cancer Research 56:5723-5727, 1996. 49. Koi M, Lamb PW, Filatov L, Feinberg AP, Barrett JC. Construction of chicken X human microcell hybrids for

human gene targeting. Cytogenetics & Cell Genetics 76:72-76, 1997.

50. Barletta JM, Rainier S, Strichman L, and Feinberg AP. Reversal of loss of imprinting in tumor cells by 5-aza-2’-deoxycytidine. Cancer Research 57:48-50, 1997.

51. Lee MP, Hu RJ, Johnson LA, and Feinberg AP. Human KvLQT1 gene shows tissue-specific imprinting and

encompasses Beckwith-Wiedemann syndrome chromosomal rearrangements. Nature Genetics 15:181-185, 1997. 52. Cost GJ, Thompson JS, Reichard BA, Lee JY, and Feinberg AP. Lack of imprinting of three human cyclin-dependent

kinase inhibitor genes. Cancer Research 57:926-929, 1997. 53. Lee MP, DeBaun M, Reichard BA, Elledge SJ, and Feinberg AP. Low frequency of p57KIP2 mutation in Beckwith-

Wiedemann syndrome. American Journal of Human Genetics 61:304-309, 1997. 54. Lee MP and Feinberg AP. Aberrant splicing but not mutations of TSG101 in human breast cancer, Cancer Research

57:3131-3134, 1997. 55. Hu R-J, Lee MP, Conners TD, Johnson LA, Burn TC, Su K, Landes GM, and Feinberg AP. A 2.5 Mb transcript map

of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes. Genomics 46:9-17, 1997.

56. Randhawa GS, Cui H, Barletta JA, Strichman-Almashanu LZ, Talpaz M, Kantarjian H, Deisseroth AB, Champlin RC,

and Feinberg AP. Loss of imprinting in disease progression in chronic myelogenous leukemia. Blood 91:3144-3147, 1998.

57. Lee MP and Feinberg AP. Genomic imprinting of a human apoptosis gene homologue, TSSC3, Cancer Research

58:1052-1056, 1998. 58. Randhawa GS, Bell DW, Testa JR, and Feinberg AP. Mapping genes encoding modifiers of human histone

acetylation. Genomics 51: 262-269, 1998. 59. Jiang S, Hemann MA, Lee MP, and Feinberg AP. Strain-dependent developmental relaxation of imprinting of an

endogenous mouse gene, KVLQT1. Genomics 53:395-9, 1998. 60. Randhawa GS, Bell DW, Testa JR, and Feinberg AP. Identification and mapping of human histone acetylation

modifier gene homologues. Genomics 51:262-269, 1998. 61. Paulsen M, Davies KR, Bowden LM, Villar AJ, Franck O, Fuermann M, Dean WL, Moore TF, Rodrigues N, Davies

KE, Hu RJ, Feinberg AP, Maher ER, Reik W, and Walter J. Syntenic organization of the mouse distal chromosome 7 imprinting cluster and the Beckwith-Wiedemann syndrome region in chromosome 11p15.5. Human Molecular Genetics 7:1149-59, 1999.

62. Lee MP, Reeves C, Schmitt A, Su K, Connors TD, Hu R-J, Brandenburg S, Lee MJ, Miller G, and Feinberg A.P.

Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5. Cancer Research 58:4155-4159, 1998.

63. Cui H, Horon IL, Ohlsson R, Hamilton SR, and Feinberg AP. Loss of imprinting in normal tissue of colorectal

cancer patients with microsatellite instability. Nature Medicine 4:1276-1280, 1998. 64. Lee MP, Brandenburg S, Landes GM, Adams M, Miller G, and Feinberg AP. Two novel genes in the center of the

11p15 imprinted domain escape genomic imprinting. Human Molecular Genetics 8:683-690, 1999. 65. Lee MP, DeBaun MR, Mitsuya K, Galonek HL, Brandenburg S, Oshimura M, and Feinberg AP. Loss of imprinting

of a paternally expressed transcript, with antisense orientation to KVLQT1, occurs frequently in Beckwith-Wiedemann syndrome and is independent of IGF2 imprinting. Proceedings of the National Academy of Sciences USA 96:5203-5208, 1999.

66. Mitsuya K, Meguro M, Lee MP, Katoh M, Schulz TC, Kugoh H, Yoshida MA, Niikawa N, Feinberg AP, and

Oshimura M. LIT1, an imprinted antisense RNA in the human KVLQT1 locus identified by screening for differentially expressed transcripts using monochromosomal hybrids. Human Molecular Genetics 8:1209-1217, 1999.

67. Ohlsson R, Cui H, He L, Pfeifer S, Malmikumpu H, Jiang S, Feinberg AP, and Hedborg F. Mosaic allelic IGF2

expression patterns reveal a link between Wilms tumorigenesis and epigenetic heterogeneity. Cancer Research 59:3889-3892, 1999.

68. Krasner, A, Wallace L, Thiagalingam A, Jones C, Lengauer C, Minahan L, Ma Y, Kalikin L, Feinberg AP, Jabs EW,

Tunacliffe A, Baylin SB, Ball DW, Nelkin BD. Cloning and chromosomal localization of the human BARX2 homeobox protein gene. Gene 250:171-180, 2000.

69. Alders M, Ryan A, Hodges M, Bliek J, Feinberg AP, Privitera O, Westerveld A, Little OF, Mannens M. Disruption of

a novel imprinted zinc-finger gene, ZNF215, in Beckwith-Wiedemann syndrome. American Journal of Human Genetics 66:1473-1484, 2000.

70. Uejima, H, Lee, MP, Cui, H, and Feinberg, AP. Hot stop PCR: A simple and general assay for linear quantitation of

allele ratios. Nature Genetics 25:375-376, 2000. 71. Onyango, P, Miller, W, Lehoczky, J, Leung, CT, Birren, B, Wheelan, S, Dewar, K, and Feinberg, AP. Sequence and

comparative analysis of the mouse 1 megabase region orthologous to the human 11p15 imprinted domain. Genome Research 10:1697-1710, 2000.

72. Lee, MP, Ravenel, JD, Hu, R-J, Lustig, LR, Hu, R, Tomaselli, G, Berger, RD, Brandenburg, SA, Litzi, TJ, Bunton, TE,

Limb, C, Francis, H, Gorelikow, M, Gu, H, Washington, K, Argani, P, Goldenring, JR, Coffey, RJ, and Feinberg, AP. Targeted disruption of the Kvlqt1 gene causes deafness and gastric hyperplasia in mice. Journal of Clinical Investigation 106:1447-1455, 2000.

73. Feinberg, AP. The two-domain hypothesis in Beckwith-Wiedemann syndrome. Journal of Clinical Investigation

106:739-740, 2000. 74. Cui H, Niemitz EL, Ravenel JD, Onyango P, Brandenburg SA, Lobanenkov VV, and Feinberg AP. LOI of IGF2 in

Wilms’ tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Research 61:4947-4950, 2001.

75. Ravenel JD, Broman KW, Perlman EJ, Niemitz EL, Jayawardena TM, Bell DW, Haber DA, Uejima H, and Feinberg

AP. Loss of imprinting of Insulin-Like Growth Factor-II (IGF2) gene in distinguishing specific biological subtypes of Wilms tumor. Journal of the National Cancer Institute 93:1698-1703, 2001.

76. Filippova GN, Qi C-F, Ulmer JE, Moore JM, Ward MD, Hu YJ, Loukinov DI, Pugacheva EM, Klenova EM, Grundy

PE, Feinberg AP, Cleton-Jansen A-M, Moerland EW, Cornelisse CJ, Suzuki H, Komiya A, Lindblom A, Dorion-Bonnet F, Neiman PE, Morse, III HC, Collins SJ, and Lobanenkov VV. Tumor-associated Zinc Finger Mutations in the CTCF Transcription Factor Selectively Alter Its DNA-binding Specificity. Cancer Research 62: 48-52, 2002.

77. DeBaun, MR, Niemitz, EL, McNeil, ED, Brandenburg, SA, Lee, MP, and Feinberg, AP. Epigenetic alterations of

H19 and LIT1 distinguish Beckwith-Wiedemann syndrome with cancer and birth defects. American Journal of Human Genetics 70:604-611, 2002.

78. Strichman-Almashanu LZ, Lee RS, Onyango PO, Perlman E, Folke F, Frieman MB, and Feinberg AP. A genome-

wide screen for normally methylated human CpG islands that can identify novel imprinted genes. Genome Research 12:543-554, 2002.

79. Rhee I, Bachman KE, Park BH, Jair K-W, Yen R-W, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW,

Baylin SB, and Vogelstein B. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 4:552-556, 2002.

80. Loukinov DI, Pugacheva E, Vatolin S, Moon H, Pack VP, Kanduri C, Cui H, Rasko JEJ, Klenova EM, Morse IIId H,

Feinberg A, Ohlsson R, and Lobanenkov VV. The germ cell-specific factors BORIS, a paralogue of the ubiquitously expressed chromatin insulator protein CTCF, is abnormally activated in multiple cancers. Proceedings of the National Academy of Sciences USA 99:6806-6811, 2002.

81. Onyango P, Jiang S, Uejima H, Shamblott MJ, Gearhart JD, Cui H, and Feinberg AP. Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages. Proceedings of the National Academy of Sciences USA 99:10599-10604, 2002.

82. Onyango P, Celic I, McCaffery JM, Boeke JD, and Feinberg AP. SIRT3, a human SIR2 homologue, is an NAD-

dependent deacetylase localized to mitochondria, Proceedings of the National Academy of Sciences USA 99:13653-13658, 2002.

83. Cui H, Onyango P, Brandenburg S, Wu Y, Hsieh C-L, and Feinberg AP. Loss of imprinting in colorectal cancer

linked to hypomethylation of H19 and IGF2. Cancer Research 62:6442-6446, 2002. 84. Kraggerud SM, Lee MP, Skotheim RI, Stenwig AE, Fossa SD, Feinberg, AP, Lothe RA. Lack of parental origin

specificity of altered alleles at 11p15 in testicular germ cell tumors. Cancer Genetics and Cytogenetics 147:1-8, 2003. 85. DeBaun MR, Niemitz EL, and Feinberg AP. Association of in vitro fertilization with Beckwith-Wiedemann

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90. Yu W, Ginjala V, Pant V, Chernukhin I, Whitehead J, Docquier F, Farrar D, Tavoosidana G, Mukhopadhyay R,

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91. Gius D, Cui H, Bradbury C, Cook J, Smart DK, Shuping Z, Young L, Brandenburg S, Hu Y, Bisht K, Ho AS, Mattson

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92. Niemitz EL, DeBaun MR, Fallon J, Murakami K, Kugoh H, Oshimura M, and Feinberg AP. Microdeletion of LIT1

in familial Beckwith-Wiedemann syndrome. American Journal of Human Genetics 75:844-849, 2004. 93. Bjornsson H, Fallin D, Feinberg AP. An integrated epigenetic and genetic approach to common human disease.

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95. Mummert SK, Lovanenkov VA, and Feinberg AP. Association of chromosome arm 16q loss with loss of imprinting

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97. Chang AS, Moley KH, Wangler M, Feinberg AP, and DeBaun MR. Association between Beckwith-Wiedemann

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98. Wangler MF, An P, Feinberg AP, Province M, and DeBaun MR. Inheritance pattern of Beckwith-Wiedemann syndrome is heterogeneous in 291 families with an affected proband. American Journal of Medical Genetics 137:16-21, 2005.

99. Niemitz E, Feinberg AP, Brandenburg SA, Grundy PE, and DeBaun MR. Children with isolated hemihypertrophy

and Beckwith Wiedemann Syndrome have different constitutional epigenotypes associated with Wilms tumor. American Journal of Human Genetics 77:887-891, 2005.

100. Postovit LM, Costa FF, Bischof JM, Seftor EA, Wen B, Seftor RE, Feinberg AP, Soares MB, and Hendrix MJ. The

commonality of plasticity underlying multipotent tumor cells and embryonic stem cells. Journal of Cellular Biochemistry 101:908-917, 2006.

101. Reinhold WC, Reimers MA, Maunakea AK, Kim S, Lababidi S, Scherf U, Shankavaram UT, Ziegler MS, Stewart C,

Kouros-Mehr H, Cui H, Dolginow D, Scudiero DA, Pommier YG, Munroe DJ, Feinberg AP, and Weinstein JN. Detailed DNA methylation profiles of the E-cadherin promoter in the NCI-60 cancer cells. Molecular Cancer Therapeutics 6:391-403, 2007.

102. Rivera MN, Kim WJ, Wells J, Driscoll DR, Brannigan BW, Han M, Kim JC, Feinberg AP, Gerald WL, Vargas SO,

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103. Bjornsson HT, Brown LJ, Fallin MD, Rongione MA, Bibikova M, Wickham E, Fan JB, Feinberg AP. Epigenetic

specificity of loss of imprinting of the IGF2 gene in Wilms tumors. Journal of the National Cancer Institute 99:1270-32007, 2007.

104. Potash JB, Buervenich S, Cox NJ, Zandi PP, Akula N, Steele J, Rathe JA, Avramopoulos D, Detera-Wadleigh SD,

Gershon ES, Depaulo JR Jr, Feinberg AP, McMahon FJ; NIMH Genetics Initiative Bipolar Disorder Consortium. Gene-based SNP mapping of a psychotic bipolar affective disorder linkage region on 22q12.3: Association with HMG2L1 and TOM1. American Journal of Medical Genetics B Neuropsychiatric Genetics 147B:59-67, 2007.

105. Ladd-Acosta C, Pevsner J, Sabunciyan S, Yolken R, Webster M, Dinkins T, Callinan PA, Fan J-B, Potash JB,

Feinberg AP. DNA methylation signatures within the human brain. American Journal of Human Genetics 81:1304-1315, 2007.

106. Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos RA,

Pearson MA, Sharov AA, Longo DL, Ko MSH, Levchenko A, Feinberg AP. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proceedings of the National Academy of Sciences USA 104:20926-331, 2007.

107. Yu W, Gius D, Onyango P, Muldoon-Jacobs K, Karp J, Feinberg AP, Cui H. Epigenetic silencing of tumour

suppressor gene p15 by its antisense RNA. Nature 451:202-206, 2007. 108. Irizarry RA, Ladd-Acosta C, Carvalho B, Wu H, Brandenburg SA, Wen B, Feinberg AP. Comprehensive high-

throughput arrays for relative methylation (CHARM). Genome Research 18:780-790, 2008. 109. Bjornsson HT, Albert TJ, Ladd-Acosta CM, Green RD, Rongione MA, Middle CM, Irizarry RA, Broman KW,

Feinberg AP. SNP-specific array-based allele-specific expression analysis. Genome Research 18:771-779, 2008. 110. Sun L, Huang L, Nguyen P, Bisht KS, Bar-Sela G, Ho AS, Bradbury CM, Yu W, Cui H, Lee S, Trepel JB, Feinberg

AP, Gius D. DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment 22 of CTCFL/BORIS and modulation of promoter histone methylation. Cancer Research 68:2726-2735, 2008.

111. Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H, Yu W, Rongione MA, Ekström TJ,

Harris TB, Launer LJ, Eiriksdottir G, Leppert MF, Sapienza C, Gudnason V, Feinberg AP. Intra-individual change over time in DNA methylation with familial clustering. JAMA 299:2877-2883, 2008.

112. Nguyen P, Cui H, Bisht KS, Sun L, Patel K, Lee RS, Kugoh H, Oshimura M, Feinberg AP, Gius D. CTCFL/BORIS is a methylation-independent DNA-binding protein that preferentially binds to the paternal H19 differentially methylated region. Cancer Research 68:5546-5551, 2008.

113. Nguyen P, Bar-Sela G, Sun L, Bisht KS, Cui H, Kohn E, Feinberg AP, Gius D. BAT3 and SET1A form a complex

with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression. Molecular and Cellular Biology 28:6720-6729, 2008.

114. Wen B, Wu H, Bjornsson H, Green RD, Irizarry RA, Feinberg AP. Overlapping euchromatin/heterochromatin-

associated marks are enriched in imprinted gene regions and predict allele-specific modification. Genome Research 11:1806-1813, 2008.

115. Irizarry R, Ladd-Acosta C, Wen B, Wu Z, Montano C, Onyango P, Cui H, Gabo K, Rongione M, Webster M, Ji H,

Potash J, Sabunciyan S, Feinberg AP. Genome-wide methylation analysis of human colon cancer reveals similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nature Genetics 41:178-186, 2009.

116. Wen B, Wu H, Shinkai Y, Irizarry RA, Feinberg AP. Large organized chromatin K9-modifications (LOCKs)

distinguish differentiated from embryonic stem cells. Nature Genetics 41:246-250, 2009. 117. Mirsaidov U, Timp W, Zou X, Dimitrov V, Schulten K, Feinberg AP, Timp G. Nanoelectromechanics of

methylated DNA in a synthetic nanopore. Biophysical Journal 96:L32-34, 2009. 118. Cruz-Correa M, Zhao R, Oviedo M, Bernabe RD, Lacourt M, Cardona A, Lopez-Enriquez R, Wexner S, Cuffari C,

Hylind L, Platz E, Cui H, Feinberg AP, Giardiello FM. Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. Epigenetics 4:114-118, 2009.

119. Irizarry RA, Wu H, Feinberg AP. A species-generalized probabilistic model-based definition of CpG islands.

Mammalian Genome 20:674-680, 2009. 120. Doi A, Park I-H, Wen B, Murakami P, Aryee MJ, Irizarry R, Herb B, Ladd-Acosta C, Rho J, Loewer S, Miller J,

Schlaeger T, Daley GQ, Feinberg AP. Differential methylation of tissue- and cancer-related CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells, and fibroblasts. Nature Genetics 41:1350-1353, 2009.

121. Feinberg AP, Irizarry RA. Stochastic epigenetic variation as a driving force of development, evolutionary adaptation,

and disease. Proceedings of the National Academy of Sciences USA 107 Suppl 1:1757-1764, 2009. 122. Wu H, Caffo B, Jaffee HA, Irizarry RA, Feinberg AP. Redefining CpG islands using hidden Markov models.

Biostatistics 3:499-514, 2010. 123. Lennerz JK, Timmerman RJ, Grange DK, Debaun MR, Feinberg AP, Zehnbauer BA. Addition of H19 'loss of

methylation testing' for Beckwith-Wiedemann Syndrome (BWS) increases the diagnostic yield. Journal of Molecular Diagnostics 12:576-588, 2010.

124. Ji H, Ehrlich LIR, Seita J, Murakami P, Doi A, Lindau P, Lee H, Aryee MJ, Kim K, Rossi DJ, Inlay MA, Serwold T,

Karsunky H, Ho L, Daley GQ, Weissman IL, Feinberg AP. A comprehensive methylome map of lineage commitment from hematopoietic progenitors. Nature 467:285-290, 2010.

125. Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A,

Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP*, Daley GQ* (*co-corresponding authors). Epigenetic memory in induced pluripotent stem cells. Nature 467:338-342, 2010.

126. Feinberg AP, Irizarry RA, Fradin D, Aryee MJ, Murakami P, Aspelund T, Eiriksdottir G, Harris TB, Launer L,

Gudnason V, Fallin MD. Personalized epigenomic signatures that are stable over time and covary with body mass index. Science Translational Medicine 15:49ra67, 2010.

127. Aryee MJ, Wu Z, Ladd-Acosta C, Herb B, Feinberg AP, Yegnasubramanian S, Irizarry RA. Accurate genome-scale percentage DNA methylation estimates from microarray data. Biostatistics 12:197-210, 2010.

128. Jaffe AE, Feinberg AP, Irizarry RA, Leek JT. Significance analysis and statistical dissection of variably methylated

regions. Biostatistics 13:166-178, 2011. 129. McDonald OG, Wu H, Timp W, Doi A, Feinberg AP. Genome-scale epigenetic reprogramming during epithelial to

mesenchymal transition. Nature Structural & Molecular Biology 18:867-874, 2011. 130. Hansen, KD Timp W, Corrada Bravo H, Sabunciyan S, Langmead B, McDonald OG, Wen B, Wu H, Liu Y, Diep D,

Briem E, Zhang K, Irizarry RA, Feinberg AP. Increased variation in epigenetic domains across cancer types. Nature Genetics 43:768-775, 2011.

131. Onyango P, Feinberg AP. A nucleolar protein, H19 opposite tumor suppressor (HOTS), is a tumor growth inhibitor

encoded by a human imprinted H19 antisense transcript. Proceedings of the National Academy of Sciences USA 108:16759-16764, 2011.

132. Lee RS, Tamashiro KL, Aryee MJ, Murakami P, Seifuddin F, Herb B, Huo Y, Rongione M, Feinberg AP, Moran

TH, Potash JB. Adaptation of the CHARM DNA methylation platform for the rat genome reveals novel brain region-specific differences. Epigenetics 11:1378-1390, 2011.

133. Kim K, Zhao R, Doi A, Ng K, Unternaehrer J, Cahan P, Hongguang H, Loh Y-H, Aryee MJ, Lensch MW, Li H,

Collins JJ, Feinberg AP*, Daley GQ* (*co-corresponding). Donor cell type influences the epigenome and differentiation potential of human induced pluripotent stem cells. Nature Biotechnology 29:1117-1110, 2011.

134. Vanaja KG, Feinberg AP, Levchenko A. Stem cell differentiation as a renewal-reward process: predictions and

validation in the colonic crypt. Advances in Experimental Medicine and Biology 736:199-209, 2012. 135. Lee H, Jaffe AE, Feinberg JI, Tryggvadottir R, Brown S, Montano C, Aryee MJ, Irizarry RA, Herbstman J, Witter FR,

Goldman LR, Feinberg AP*, Fallin MD. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. International Journal of Epidemiology 41:188-199, 2012. (*corresponding author)

136. Jaffe AE, Murakami P, Lee H, Leek JT, Fallin MD, Feinberg AP, Irizarry RA. Bump hunting to identify

differentially methylated regions in epigenetic epidemiology studies. International Journal of Epidemiology 41:200-209, 2012.

137. Sabunciyan S, Aryee MJ, Irizarry RA, Rongione M, Webster MJ, Kaufman WE, Murakami P, Lessard A, Yolken RH,

Feinberg AP, Potash JB; GenRED Consortium. Genome-wide DNA methylation scan in major depressive disorder. PLoS One 7:e34451, 2012.

138. Pujadas E, Feinberg AP. A role for regulated noise in the epigenetic landscape of development and disease. Cell

148:1123-1131, 2012. 139. Herb B, Wolschin F, Aryee M, Langmead B, Amdam G, Feinberg AP. Reversible switching between epigenetic

states in honeybee behavioral subcasts. Nature Neuroscience 15:1371-1373, 2012. 140. Wen B, Wu H, Loh YH, Briem E, Daley GQ, Feinberg AP. Euchromatin islands in large heterochromatin domains

are enriched for ctcf binding and differentially DNA-methylated regions. BMC Genomics 13:566-576, 2012. 141. Liu Y, Aryee JM, Padyukov L, Fallin MD, Hesselberg E, Runarsson A, Reinius L, Acevedo N, Taub M, Ronninger

M, Shchetynsky K, Scheynius A, Kere J, Alfredsson L, Klareskog L, Ekstrom TJ, Feinberg AP. Epigenome-wide association data implicates DNA methylation as an intermediary of genetic risk in rheumatoid arthritis. Nature Biotechnology 31:142-147, 2013.

142. Fraleigh-Lohrfink, K, Schneider V, Whittington D, Feinberg AP. Increase in science research commitment in a

didactic and laboratory based program targeted to gifted minority high-school students. Roeper Review 35:1, 18-26, 2013.

143. Ladd-Acosta C, Hansen KD, Briem E, Fallin MD, Kaufmann WE, Feinberg AP. Common DNA methylation

alterations in multiple brain regions in autism. Molecular Psychiatry, 19:862:871, 2014 (Epub 2013). 144. Montaño CM, Irizarry RA, Kaufmann WE, Talbot K, Gur RE, Feinberg AP, Taub MA. Measuring cell-type specific

differential methylation in human brain tissue. Genome Biology 30:R94, 2013. 145. Hansen KD, Sabunciyan S, Langmead B, Nagy N, Curley R, Klein G, Klein E, Salamon D, Feinberg AP. Large-

scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization. Genome Research 24:177-184, 2013.

146. Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA. Minfi: a flexible and

comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics 30:1363-1339, 2014.

147. Liu Y, Li X, Aryee MJ, Ekstrom TJ, Padyukov L, Klareskog L, Vandiver A, Moore AZ, Tanaka T, Ferrucci L, Fallin

MD, Feinberg AP. GeMes: Clusters of DNA methylation under genetic control can 25 inform genetic and epigenetic analysis of disease. American Journal of Human Genetics 94:485-495, 2014.

148. Prusevich P, Kalin JH, Ming SA, Basso M, Givens J, Li X, Hu J, Taylor MS, Cieniewicz AM, Hsiao PY, Huang R,

Roberson H, Adejola N, Avery LB, Casero RA Jr, Taverna SD, Qian J, Tackett AJ, Ratan RR, McDonald OG, Feinberg AP, Cole PA. A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1. ACS Chemical Biology 9:1284-1293, 2014.

149. Timp W, Bravo HC, McDonald O, Goggins M, Umbricht C, Zeiger M, Feinberg AP*, Irizarry RA* (*co-

corresponding authors). Large hypomethylated blocks as a universal defining epigenetic alteration in human solid tumors. Genome Medicine 6:61, 2014.

150. Sinha S, Thomas D, Yu L, Gentles AJ, Jung N, Corces-Zimmerman MR, Chan SM, Reinisch A, Feinberg AP, Dill

DL, Majeti R. Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition. Blood 316-326, 2014.

151. Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald K, Godfrey

M, Gupta D, McPherson J, Malwadkar P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Brookes E, Cherry AB, Demirbas D, Tsankov AM, Zon LI, Rubin LL, Feinberg AP, Meissner A, Cowan CA, Daley GQ. A comparison of non-integrating reprogramming methods. Nature Biotechnology 33:58-63, 2015.

152. Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M,

Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, Feinberg AP. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metabolism 21:138-149, 2015.

153. Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR,

Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, Feinberg AP, Fallin M, Multhaup ML, Jaffe AE, Joehanes R, Schwartz J, Just AC, Lunetta KL, Murabito JM, Starr JM, Horvath S, Baccarelli AA, Levy D, Visscher PM, Wray NR, Deary IJ. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology 16:25, 2015.

154. Feinberg JI, Bakulski KM, Jaffe AE, Tryggvadottir R, Brown SC, Goldman LR, Croen LA, Hertz-Picciotto I,

Newschaffer CJ, Daniele Fallin M, Feinberg AP. Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort. International Journal of Epidemiology 44:1199-1210, 2015.

155. Vandiver AR, Irizarry RA, Hansen KD, Garza LA, Runarsson A, Li X, Chien AL, Wang TS, Leung SG, Kang S,

Feinberg AP. Age and sun exposure-related widespread genomic blocks of hypomethylation in nonmalignant skin. Genome Biology 16:80, 2015.

156. Bakulski KM, Lee H, Feinberg JI, Wells EM, Brown S, Herbstman JB, Witter FR, Halden RU, Caldwell K,

Mortensen ME, Jaffe AE, Moye J Jr, Caulfield LE, Pan Y, Goldman LR, Feinberg AP, Fallin MD. Prenatal mercury

concentration is associated with changes in DNA methylation at TCEANC2 in newborns. International Journal of Epidemiology, 44:1249-1262, 2015.

157. Jung N, Dai B, Gentles AJ, Majeti R, Feinberg AP. An LSC epigenetic signature is largely mutation-independent and

implicates the HOXA cluster in AML pathogenesis. Nature Communications 6:8489, 2015. 158. Ladd-Acosta C, Shu C, Lee BK, Gidaya N, Singer A, Schieve LA, Schendel DE, Jones N, Daniels JL, Windham GC,

Newschaffer CJ, Croen LA, Feinberg AP, Daniele Fallin M. Environmental Research, Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood. Environmental Research 144(Pt A):139-148, 2016.

159. Vandiver AR, Idrizi A, Rizzardi L, Feinberg AP, Hansen KD. DNA methylation is stable during replication and cell

cycle arrest. Scientific Reports 5:17911, 2015. 160. Bakulski KM, Feinberg JI, Andrews SV, Yang J, Brown S, McKenney S, Witter F, Walston J, Feinberg AP, Fallin

MD. DNA methylation of cord blood cell types: Applications for mixed cell birth studies. Epigenetics 11:354-362, 2016.

161. Joubert BR, Felix JF, Yousefi P, Bakulski KM, Just AC, Breton C, Reese SE, Markunas CA, Richmond RC, Xu CJ,

Küpers LK, Oh SS, Hoyo C, Gruzieva O, Söderhäll C, Salas LA, Baïz N, Zhang H, Lepeule J, Ruiz C, Ligthart S, Wang T, Taylor JA, Duijts L, Sharp GC, Jankipersadsing SA, Nilsen RM, Vaez A, Fallin MD, Hu D, Litonjua AA, Fuemmeler BF, Huen K, Kere J, Kull I, Munthe-Kaas MC, Gehring U, Bustamante M, Saurel-Coubizolles MJ, Quraishi BM, Ren J, Tost J, Gonzalez JR, Peters MJ, Håberg SE, Xu Z, van Meurs JB, Gaunt TR, Kerkhof M, Corpeleijn E, Feinberg AP, Eng C, Baccarelli AA, Benjamin Neelon SE, Bradman A, Merid SK, Bergström A, Herceg Z, Hernandez-Vargas H, Brunekreef B, Pinart M, Heude B, Ewart S, Yao J, Lemonnier N, Franco OH, Wu MC, Hofman A, McArdle W, Van der Vlies P, Falahi F, Gillman MW, Barcellos LF, Kumar A, Wickman M, Guerra S, Charles MA, Holloway J, Auffray C, Tiemeier HW, Smith GD, Postma D, Hivert MF, Eskenazi B, Vrijheid M, Arshad H, Antó JM, Dehghan A, Karmaus W, Annesi-Maesano I, Sunyer J, Ghantous A, Pershagen G, Holland N, Murphy SK, DeMeo DL, Burchard EG, Ladd-Acosta C, Snieder H, Nystad W, Koppelman GH, Relton CL, Jaddoe VW, Wilcox A, Melén E, London SJ. DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis. American Journal of Human Genetics 98:680-696, 2016.

162. Montano C, Taub MA, Jaffe A, Briem E, Feinberg JI, Trygvadottir R, Idrizi A, Runarsson A, Berndsen B, Gur RC,

Moore TM, Perry RT, Fugman D, Sabunciyan S, Yolken RH, Hyde TM, Kleinman JE, Sobell JL, Pato CN, Pato MT, Go RC, Nimgaonkar V, Weinberger DR, Braff D, Gur RE, Fallin MD, Feinberg AP. Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study. JAMA Psychiatry 73:506-514, 2016.

163. Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R,

Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL; WHI-EMPC Investigators., Fiorito G; CHARGE epigenetics of Coronary Heart Disease., Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A. DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biology 17:255, 2016.

164. Gomez-Cabrero D, Almgren M, Sjöholm LK, Hensvold AH, Ringh MV, Tryggvadottir R, Kere J, Scheynius A,

Acevedo N, Reinius L, Taub MA, Montano C, Aryee MJ, Feinberg JI, Feinberg AP, Tegnér J, Klareskog L, Catrina AI, Ekström TJ. High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis. Genome Medicine 8:124, 2016.

165. Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, Roetker NS, Just AC, Demerath EW,

Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling LC, Price TR, Singleton AB, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W,

Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AF, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D, Baccarelli A, van Meurs J, Bell JT, Peters A, Deary IJ, Pankow JS, Ferrucci L, Horvath S. DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging 8:1844-1865, 2016.

166. Rizzardi LF, Kunz H, Rubins K, Chouker A, Quiriarte H, Sams C, Crucian BE, Feinberg A.P. valuation of

techniques for performing cellular isolation and preservation during microgravity conditions. NPJ Microgravity 2:16025, 2016.

167. Li X, Liu Y, Salz T, Hansen KD, Feinberg AP. Whole genome analysis of the methylome and hydroxymethylome in

normal and malignant lung cancer. Genome Research 26:1730-1741, 2016. 168. Andrews SV, Ladd-Acosta C, Feinberg AP, Hansen KD, Fallin MD. "Gap hunting" to identify multimodal

distributions of DNA methylation. Epigenetics & Chromatin 9:56, eCollection, 2016. 169. Meng W, Zhu Z, Jiang X, Too CL, Uebe S, Jagodic M, Kockum I, Murad S, Ferrucci L, Alfredsson L, Zou H,

Klareskog L, Feinberg AP, Ekström TJ, Padyukov L, Liu Y. DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis. Arthritis Res Ther. 19:71, 2017.

170. McDonald OG, Li X, Saunders T, Tryggvadottir R, Mentch SJ, Warmoes MO, Word AE, Carrer A, Salz TH,

Natsume S, Stauffer KM, Makohon-Moore A, Zhong Y, Wu H, Wellen KE, Locasale JW, Iacobuzio-Donahue C, Feinberg AP. Large-scale epigenomic reprogramming links anabolic glucose metabolism to distant metastasis during the evolution of pancreatic cancer progression. Nature Genetics 49:367-376, 2017.

171. Jenkinson G, Pujadas E, Goutsias J, Feinberg AP. Potential energy landscapes define the information-theoretic

nature of the epigenome. Nature Genetics 49:719-729, 2017. 172. McIntyre ABR, Rizzardi L, Yu AM, Alexander N, Rosen GL, Botkin DJ, Stahl SE, John KK, Castro-Wallace SL,

McGrath K, Burton AS, Feinberg AP, Mason CE. Nanopore sequencing in microgravity. NPJ Microgravity 2:16035, 2016.

173. Marabita F, Almgren M, Sjöholm LK, Kular L, Liu Y, James T, Kiss NB, Feinberg AP, Olsson T, Kockum I,

Alfredsson L, Ekström TJ, Jagodic M. Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship. Scientific Reports 7:14589, 2017.

174. GTEx Consortium. Landscape of X chromosome inactivation across human tissues. Nature 550:244-8, 2017. 175. GTEx Consortium. Genetic effects on gene expression across human tissues. Nature 550:203-13, 2017. 176. GTEx Consortium. Dynamic landscape and regulation of RNA editing in mammals. Nature 550:249-54, 2017. 177. GTEx Consortium. The impact of rare variation on gene expression across tissues. Nature 550:239-243, 2017. 178. eGTEx Project. Enhancing GTEx by briding the gaps between genotype, gene expression, and disease. Nature

Genetics 12:1664-70, 2017. 179. Jenkinson G, Abante J, Feinberg AP, Goutsias J. An information-theoretic approach to the modeling and analysis

of whole-genome bisulfite sequencing data. BMC Bioinformatics 19:87, 2018. 180. Wilton R, Li X, Feinberg AP, Szalay AS. Arioc: GPU-accelerated alignment of short bisulfite-treated reads.

Bioinformatics 34:2673-2675, 2018. 180. Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M,

Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström

TJ, Kockum I, Feinberg AP*, Jagodic M* (co-corresponding author). DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. Nature Communications 9:2397, 2018.

181. Andrews SV, Sheppard B, Windham GC, Schieve LA, Schendel DE, Croen LA, Chopra P, Alisch RS, Newschaffer

CJ, Warren ST, Feinberg AP, Fallin MD, Ladd-Acosta C. Case-control meta-analysis of blood DNA methylation and autism spectrum disorder. Molecular Autism 9:40, 2018.

182. NASA Twins Study (co-corresponding author). A multi-dimensional, molecular and physiological analysis of a year-

long human spaceflight. Science, in press. 183. Vanaja KG, Timp W, Feinberg AP*, Levchenko A* (co-corresponding author). A loss of epigenetic control can

promote cell death through reversing the balance of pathways in a signaling network. Molecular Cell 72:60-70, 2018. 184. Rizzardi LF, Hickey PF, Rodriguez DiBlasi V, Tryggvadóttir R, Callahan CM, Idrizi A, Hansen KD, Feinberg AP.

Neuronal brain region-specific DNA methylation and chromatin accessibility are associated with neuropsychiatric disease heritability. Nature Neuroscience 22:307-316, 2019.

185. Koldobskiy MA, Jenkinson G, Rodriguez DiBlasi VA, Zhou W, Abante J, Pujadas E, Tryggvadottir R, Callahan C,

Idrizi A, Brown PA, Ji H, Goutsias, J, Feinberg AP. Epigenetic Potential Energy Landscapes Reveal Drivers of Childhood Leukemia. In review.

Conceptual and Review Articles 1. Feinberg AP and Coffey DS. The topology of DNA loops: A possible link between nuclear matrix structure and

nucleic acid function. In The Nuclear Envelope and the Nuclear Matrix (Maul GG, Ed.), New York: Alan R. Liss, 1982.

2. Feinberg AP and Coffey DS. The concept of DNA rearrangement in human carcinogenesis and development of

tumor cell heterogeneity. In Tumor Cell Heterogeneity: Origins and Implications (Owens AH, Coffey DS, Baylin SB, Eds.), Missouri: Academic Press, 1982.

3. Feinberg AP. The molecular biology of human cancer. Progress in Clinical Biological Research 198:279-292, 1985. 4. Feinberg AP and Vogelstein B. Alterations in DNA methylation in human colon neoplasia. Seminars in Surgical

Oncology 3:149-151, 1987. 5. Feinberg AP. Alterations in DNA methylation in colorectal polyps and cancer. Progress in Clinical Biological

Research 279:307-317, 1988. 6. Feinberg AP, Law DJ, Lefrancois D, Delattre O, and Thomas G. A multistep genetic model of human colorectal

carcinogenesis. Cancer Cells 7: 245-248, Cold Spring Harbor Laboratory 1989. 7. Feinberg AP. The molecular genetics of DNA methylation in colorectal cancer. In Cell and Molecular Biology of

Human Colon Cancer (Augenlicht L, Ed.), CRC Critical Reviews, CRC Press, pp 187-198, 1989. 8. Wolman SR, Camuto P, and Feinberg AP. Genetic markers of colonic neoplasia. In The Molecular Biology of Familial

Adenomatosis Polyposis (Herrera L, Ed.), New York: Alan R. Liss, pp 371-382, 1990. 9. Feinberg AP and Rainier S. A novel strategy for identifying potential targets of altered DNA methylation in neoplastic

transformation. UCLA Symposia on Molecular and Cellular Biology New Series: Nucleic Acid Methylation, New York: Alan R. Liss, pp 211-228, 1990.

10. Olschwang S, Delattre O, Leroy H, Remvikos Y, Melot T, Law DJ, Feinberg AP, and Thomas G. A subset of genetic

alterations distinguish distal from proximal colorectal cancer. In Hereditary Colorectal Cancer, (Utsunomiya, J and Lynch HT, Eds.), New York: Springer-Verlag, pp 519-527, 1990.

11. Feinberg AP. Human colorectal cancer. In The Molecular Diagnostics of Human Cancer, (Cossman J, Ed.), New

York: Elsevier, pp. 419-430, 1990.

12. Feinberg AP. Labeling of probes by the random primer procedure. In Methods in Gene Technology Volume 1, (Dale

JW and Sanders PG, Eds.), London: JAI Press, pp. 63-70, 1991. 13. Deisseroth AB, Herst CV, Wedrychowski A, Sims S, Seong D, Johnson E, Yuan T, Romine M, Paslidis N, Emerson

S, Feinberg AP, Gao P, Huston L, Claxton D, Kornblau S, LeMaistre F, Kantarjian H, Talpaz M, Reading C, and Spitzer G. Novel approaches to the therapy of CML. In New Strategies in Bone Marrow Transplantation (Champlin R and Gale RP, Eds.), New York: Wiley-Liss, pp. 163-169, 1991.

14. Boland CR and Feinberg AP. Neoplasia of the gastrointestinal tract. In Textbook of Gastroenterology Volume 1,

(Yamada T, Alpers D, Owyang, C, Powell, D, and Silverstein F, Eds.), Philadelphia: J.B. Lippincott, pp. 501-518, 1991.

15. Feinberg AP. Science Citation Classic: Radiolabeling DNA fragments by random priming. Current Contents 36:8,

1993. 16. Feinberg AP, Kalikin LM, Thompson JS. Loss of imprinting in human cancer. Cold Spring Harbor Symposia on

Quantitative Biology: Molecular Genetics of Cancer, 59:357-363, 1994. 17. Feinberg AP. A developmental context for multiple genetic alterations in Wilms tumor. Journal of Cell Science,

Supplement, 18:7-12, 1994. 18. Feinberg AP. A domain of abnormal imprinting in human cancer. In Nobel Conference on Genomic Imprinting:

Causes and Consequences, (R. Ohlsson, K. Hall, and M. Ritzen, Eds.), Cambridge University Press, pp. 273-292, 1995.

19. Feinberg AP. Multiple genetic abnormalities of 11p15 in Wilms tumor. Medical and Pediatric Oncology 27:484-489,

1996. 20. Feinberg AP, Rainier S, DeBaun MR. Genomic imprinting, DNA methylation and cancer. Journal of the National

Cancer Institute Monographs 17:21-26, 1995. 21. Alders M, Bliek J, Redeker B, Ryan A, Feinberg A, Westerveld A, Little P, and Mannens M. Cloning of candidate

genes involved in the Beckwith-Wiedemann syndrome and childhood tumors. Medical & Pediatric Oncology 27:495-497, 1996.

22. Mannens M, Alders M, Redeker B, Bliek J, Steenman M, Wiesmeyer C, de Meulemeester M, Ryan A, Kalikin L, Voute

T, De Kraker J, Hoovers J, Slater R, Feinberg A, Little P, and Westerveld A. Positional cloning of genes involved in the Beckwith-Wiedemann syndrome, hemihypertrophy, and associated childhood tumors. Medical & Pediatric Oncology 27:490-494, 1996.

23. Feinberg AP. Genomic imprinting and cancer. In Genetic Basis of Human Cancer (B Vogelstein & K Kinzler, Eds.),

McGraw Hill Medical Publishing, New York, 1997. 24. Feinberg AP. Genomic imprinting as a developmental process disturbed in cancer. In Genomic Imprinting: Frontiers

in Molecular Biology (W Reik and A Surani, Eds.), IRL Press at Oxford University Press, 1997. 25. Elias ER, DeBaun MR, and Feinberg AP. Beckwith-Wiedemann syndrome. In Principles of Molecular Medicine (J L

Jameson, Ed.), Humana Press, Inc., 1998. 26. Feinberg AP. Mendel stayed home. Trends in Genetics 15: 46-47, 1999. 27. Feinberg AP. Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction. Cancer

Research 59:1743s-1746s, 1999. 28. Feinberg, AP. DNA methylation, genomic imprinting and cancer in Current Topics in Microbiology and Immunology

249:87-99, 2000.

29. Feinberg, AP. Genomic imprinting and cancer. In The Metabolic and Molecular Bases of Inherited Disease, 8th Edition (C. Scriver, et al., Eds.) McGraw-Hill, New York, pp 525-537, 2001.

30. Feinberg, AP. Cancer epigenetics takes center stage. Proceedings of the National Academy of Sciences USA,98:392-

394, 2001. 31. Feinberg, AP. Methylation meets genomics. Nature Genetics 27:9-10, 2001. 32. Feinberg AP, Cui H, and Ohlsson R. DNA methylation and genomic imprinting: insights from cancer into epigenetic

mechanisms. Seminars in Cancer Biology 12:389-398, 2002. 33. Feinberg AP, Oshimura M, and Barrett JC. Epigenetic mechanisms in human disease. Cancer Research 62:6784-6787,

2002. 34. Feinberg, AP, and Williams, BRG. Wilms’ tumor as a model for cancer biology. In Tumor Suppressor Genes (WS El-

Deiry, Ed.) Humana Press, 222:239-248, 2003. 35. Ohlsson R, Kanduri C, Whitehead J, Pfeifer S, Lobanenkov V, Feinberg AP. Epigenetic variability and the evolution

of human cancer. Advances in Cancer Research 88:145-168, 2003. 36. Feinberg AP and Niemitz EL. Imprinting disorders. In Encyclopedia of the Human Genome (Cooper DN, Ed.)

Nature Publishing Group, London, 3:426-429, 2003. 37. DeBaun MR and Feinberg AP. IGF2, H19, p57KIP2 , and LIT1 and the Beckwith-Wiedemann Syndrome. In Inborn

Errors of Development (Epstein C, Erickson R, Eds.) Oxford University Press, 2004. 38. Feinberg AP and Tycko B. The history of cancer epigenetics. Nature Reviews Cancer 4:143-153, 2004. 39. Niemitz EL and Feinberg AP. Epigenetics and assisted reproductive technology: A call for investigation. American

Journal of Human Genetics 74:599-609, 2004. 30 40. Feinberg AP. The epigenetics of cancer etiology. Seminars in Cancer Biology 14:427-432, 2004. 41. Bjornsson HT, Gius D, Feinberg AP. The new field of epigenomics: Implications for cancer and other common

disease research. Cold Spring Harbor Symposia on Quantitative Biology: Epigenetics 69:1-10, 2004. 42. Feinberg AP. Cancer epigenetics is no Mickey Mouse. Cancer Cell 8:267-268, 2005. 43. Feinberg AP. A genetic approach to cancer epigenetics. Cold Spring Harbor Symposia on Quantitative Biology:

Molecular Approaches to Controlling Cancer 70:335-341, 2005. 44. Kaneda A and Feinberg AP. Loss of imprinting of IGF2: A common epigenetic modifier of intestinal tumor risk.

Cancer Research 65:11236-11240, 2005. 45. Feinberg AP, Ohlsson R, and Henikoff S. The epigenetic progenitor origin of human cancer. Nature Reviews Genetics

7:21-33, 2005. 46. Callinan PA and Feinberg AP. The emerging science of epigenomics. Human Molecular Genetics 15:R95-R101, 2006. 47. Feinberg AP. An epigenetic approach to cancer etiology. Cancer Journal 13:70-74, 2007. 48. Gosden RG and Feinberg AP. Genetics and epigenetics-nature’s pen-and-pencil set. New England Journal of

Medicine 7:731-733, 2007. 49. Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature 24:433-40, 2007. 50. Feinberg AP. Epigenetics at the epicenter of modern medicine. JAMA 299:1345-50, 2008.

51. American Association for Cancer Research Human Epigenome Task Force; European Union, Network of Excellence, Scientific Advisory Board. Moving AHEAD with an international human epigenome project. Nature 454:711-715, 2008.

52. Timp W, Levchenko A, Feinberg AP. A new link between epigenetic progenitor lesions in cancer and the dynamics of

signal transduction. Cell Cycle 8:383-90, 2009. 53. Feinberg AP. Genome-scale approaches to the epigenetics of common human disease. Virchows Archiv 456:13-21

(2010). 54. Ladd-Acosta C, Aryee M, Ordway JM, Feinberg AP. Comprehensive high-throughput arrays for relative methylation

(CHARM). Current Protocols in Human Genetics, Chapter 20: Unit 20.1.1-19, 2010. 55. Feinberg AP. The Epigenesis of an Epigeneticist. In Medicine, Science and Dreams (Schwartz D, Ed.). Springer: New

York, 2010. 56. Feinberg AP. Epigenomics reveals a functional genome anatomy and a new approach to common disease. Nature

Biotechnology 10:1949-1952, 2010. 57. Reddy KL, Feinberg AP. Higher-order chromatin organization in cancer. Seminars in Cancer Biology 23:109-115,

2013. 58. Feinberg AP. A third-generation method reveals cell lineage ancestry. Nature Methods 10:117-118, 2013. 59. Feinberg AP. The epigenetic basis of common human disease. Trans Am Clin Climatol Assoc124:84-93, 2013. 60. Timp W, Feinberg AP. Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the

host. Nature Reviews Cancer 13:497-510, 2013. 61. Feinberg AP. Epigenetic stochasticity, nuclear structure and cancer: the implications for medicine. Journal of Internal

Medicine 276:5-11, 2014. 62. Feinberg AP. The nucleolus gets the silent treatment. Cell Stem Cell 15:6756-676, 2014. 63. Feinberg AP, Fallin D. Epigenetics at the crossroad of genes and the environment in human disease. JAMA 314:1129-

1130, 2015. 64. Feinberg AP, Koldobskiy MA, Gondor A. Epigenetic modulators, modifiers, and mediators in cancer etiology and

progression. Nature Reviews Genetics 17:284-99, 2016. 65. eGTEx Project. Enhancing GTEx by bridging the gaps between genotype, gene expression, and disease. Nature

Genetics 49:1664-1670, 2017. 65. Feinberg AP. The key role of epigenetics in human disease prevention and mitigation. New England Journal of

Medicine 378:1323-1334, 2018. FUNDING (in chronological order)

1/9/89 – 12/31/93 National Institutes of Health R01 CA48932 (P.I.) Identification of the Earliest Steps in Transformation

10/1/86 – 2/28/94 Howard Hughes Medical Institute

12/1/89 – 1/30/03 National Institutes of Health P01 CA49639 (PI: Champlin, Co-Investigator: Feinberg) Therapy of CML

5/1/91 – 4/30/01 National Institutes of Health

R01 CA54358 (P.I.) BWS and Embryonal Tumor Suppressor Genes on 11p15

4/1/91 – 5/31/99 March of Dimes Birth Defects Foundation 6-FY-95-0218 (P.I.) The Molecular Genetics of Beckwith-Wiedemann Syndrome

4/1/94 – 1/31/13 National Institutes of Health R01 CA65145 (P.I.; transferred to A. Levchenko in 2011) Genomic Imprinting in Cancer

10/1/94 – 2/28/98 6/1/99 – 5/31/05

U. S. Army Breast Cancer Research Program DAMD17-94-J-4308 (P.I.) Identification and Characterization of Molecular Abnormalities of 11p Genes in Human

Breast Cancer March of Dimes Birth Defects Foundation FY99-252 (P.I.) Developing Novel Therapeutic Strategies for Disorders Involving Genomic Imprinting

6/1/05 – 5/31/08 March of Dimes Birth Defects Foundation FY05-79 (P.I.) Imprinted Genes Linked to Birth Defects

5/13/04 – 4/30/15 National Institutes of Health

P50 HG003233 (P.I.) Center of Excellence in Genome Sciences in Epigenetics

5/1/05 – 3/31/07 National Institutes of Health

R01 CA65145 Supplement (P.I.) Integrated Microfluidic, Cell and Molecular Approach to Igf2 Signaling and LOI (competitive supplement)

5/1/01 – 4/30/13 National Institutes of Health R37 CA54358 (P.I.) BWS and Embryonal Tumor Suppressor Genes on 11p15

10/1/05 – 9/30/09 Doris Duke Charitable Foundation 20030030 (P.I.) Development of the First Test for Common Cancer Risk in the General Population

7/1/07 – 6/30/09 National Institutes of Health R21 CA128498 (P.I.) Functional Allelotyping

7/1/07 – 6/30/10 Human Frontier Science Program RGP0058/2010-C (Co-Inv.) Capturing the methylome by a Novel Approach to Functional Proteomics

10/01/08 – 6/30/13 National Institutes of Health U01 MH085270 (P.I.) A Genome-wide Methylation Scan for Epigenetic Contributions to Schizophrenia

7/1/09 – 6/30/13 Department of Defense W81XWWH-09-1-0515 (P.I.)

Discordant Monozygotic Twins as a Model for Genetic-Environmental Interaction in Autism

9/1/09 – 6/30/15 National Institutes of Health

Roadmap R01 ES017646 (Co-P.I.) Environment, the Perinatal Epigenome, and Risk for Autism and Related Disorders

9/30/09 – 9/29/11 National Institutes of Health RC2 HL102815 (Co-Inv.) Comparative Phenotypic, Functional, and Molecular Analysis of ESC and iPSC

9/30/09 – 6/29/11 National Institutes of Health RC2 MH090043 (P.I.) Family-based Genome-wide Methylation Scan in Schizophrenia

7/1/11 – 6/30/14 NHLBI Progenitor Cell Biology Consortium RFP PCBC 2011 (P.I.) Genome-wide Methylation Analysis of Human Hematopoietic Progenitors

7/30/11 – 5/31/16 National Institutes of Health R01 AG042187 (co-P.I.) The Role and Genetic Mechanism of Epigenetic Plasticity in Age-Related Disease

9/30/11 – 7/31/16 National Institutes of Health

DP1 OD008324 (P.I.) NIH Director’s Pioneer Award

7/1/13 – 6/30/23 National Institutes of Health

R01 CA54358 (P.I.) Epigenetic Drivers of Cancer Progression

11/1/13 – 10/31/18 National Institutes of Health

U01 MH104393 (P.I.) Strategic mapping of tissue and population methylation for mental health research

9/1/14 – 8/31/18 National Aeronautics and Space Administration NASA 13-13-Twins-009 (P.I.) Comprehensive whole genome analysis of differential epigenetic effects of space travel

on monozygotic twins

9/1/14 – 8/31/17 The V Foundation for Cancer Research (Co-P.I.) Epigenetic Detection and Chemoprevention of Skin Cancer

9/28/16 – 8/31/21 National Institutes of Health RM1 HG008529 (P.I.) Integration of Genomics and the Environment

1/1/18 – 12/31/20 Lustgarten Foundation (P.I.) Targeting the epigenomic-metabolomic foundation of PDAC metastasis

4/20/18 – 4/19/23 Celgene (P.I.) Celgene License Pathway Agreement

9/4/18 – 7/31/23 National Institutes of Health

1DP1DK119129 (P.I.)

Epigenetic Drivers of Intrinsic Phenotypic Variability in Metabolic Disease CLINICAL ACTIVITIES

1979-1980 United States Public Health Service, East Baltimore Medical Plan and Johns Hopkins Hospital

1983, 1985 Field studies of the Old Order Amish 1986-1994 Attending Physician, Medical Genetics Service, University of Michigan Hospital 1986-1994 Attending Physician, General Medicine Inpatient Service, University of Michigan

Hospital 1994-2003 Attending Physician, Medical Genetics Service, Johns Hopkins Hospital 1994-2009 Medical Advisory Board, Beckwith-Wiedemann Support Network

Board Certification

1977 National Board of Medical Examiners, Diplomate 1984 American Board of Internal Medicine, Certified 1987 American Board of Medical Genetics, Certified

EDUCATIONAL ACTIVITIES Teaching

1986-1994 Graduate Thesis Committees (6), University of Michigan Medical School 1987-1994 Course Director, Methods in Molecular Genetics, Department of Human Genetics,

University of Michigan Medical School 1994-2006 Co-Director, Core Course, Graduate Program in Human Genetics, Johns Hopkins

University 1994-Present Graduate Thesis Committees (7), Johns Hopkins University School of Medicine 1995 Section Leader, Molecules & Cells, Johns Hopkins University School of Medicine 1995-Present Lecturer and Discussion Leader, Bar Harbor Short Course in Medical & Experimental

Mammalian Genetics, Jackson Laboratory 1997-Present Lecturer, Fundamentals of Genetics, Johns Hopkins University School of Medicine 1997-Present Core Discussion Leader, Graduate Programs in Biochemistry, Cellular and Molecular

Biology, and Cellular and Molecular Medicine, Johns Hopkins University School of Medicine

1998-2001 Core Discussion Co-Director, Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine

1998-Present Lecturer, Molecules and Cells, Johns Hopkins University School of Medicine 2003-Present

Director, Epigenetics Course, Graduate Program in Biochemistry, Cellular and Molecular Biology, Johns Hopkins University School of Medicine

2003-Present Director, Center Scholars Program, partnership with Center for Talented Youth for specialized curriculum and laboratory internships in genetics/genomics for minority high school students (32 students to date)

2005 Symposium Director, Completing the Book of Life: Epigenetics in Science and Medicine, Johns Hopkins University School of Medicine

2009 Symposium for the 50th Anniversary, Jackson Laboratory Short Course on Medical and Experimental Mammalian Genetics

2007-Present Lecturer, Jackson Laboratory Annual Short Course on Experimental Models of Human Cancer

2011-Present Lecturer, Core Curriculum, Johns Hopkins MD Program

2017-Present Co-Director, Physical Epigenetics, Whiting School of Engineering semester course for upper level undergraduates and first year graduate students

Mentoring

1983-1986 Susan Goelz, Ph.D., Postdoctoral Fellow The role of DNA methylation in cancer Group Leader, Biogen, Inc.

1986-1987 Anthony E. Reeve, Ph.D., Sabbatical A tumor suppressor gene on chromosome 11p15 Professor, Department of Biochemistry, University of Otago, New Zealand

1986-1990 Shirley Rainier, Ph.D., Postdoctoral Fellow Genomic imprinting in human disease Research Assistant Professor, University of Michigan

1987-1989 April Joy Ping, M.D., Ph.D., Graduate Student Linkage studies of Beckwith-Wiedemann syndrome Clinical Assistant Professor, University of Michigan

1988-1990 Stephen E. Kuehn, M.D., Postdoctoral Fellow Positional cloning of the WAGR domain Gastroenterologist, Jacksonville, FL

1989-1990 Peter J. Lee, M.D., Ph.D., Graduate Student Genetics of DNA methyltransferase Cardiologist, University of Wisconsin

1990-1991 C. Richard Boland, M.D., Sabbatical Micro-allelotyping to assay genetic alterations in situ Chief of Gastroenterology, Baylor Health Care System

1991-1994 Minoru Koi, Ph.D., Postdoctoral Fellow Genetic complementation with large genomic inserts Senior Lecturer, Brunel University, UK

1991-1994 Jae-Yong Lee, Ph.D., Postdoctoral Fellow Use of Muntjac hybrids to purify human chromosomes Associate Professor, Hallym University, Korea

1991-1994 Linda M. Kalikin, Ph.D., Graduate Student Molecular genetics of Beckwith-Wiedemann syndrome Research Scientist, University of Michigan

1992-1994 Marja J. Steenman, Ph.D., Graduate Student Mechanisms of diseases involving genomic imprinting Assistant Professor, INSERM, Nantes, France

1994-1996 Ren-Ju Hu, Ph.D., Postdoctoral Fellow Positional cloning of genes on 11p15 Staff Scientist, NIH/NIAID

1995-1997 Maxwell P. Lee, Ph.D., Research Associate Molecular genetics of Beckwith-Wiedemann syndrome Section Chief, NIH/NCI

1995-1998 Jeffrey S. Thompson, Ph.D., Postdoctoral Fellow Imprinted genes on 11p15 Associate Professor, Denison University

1995-1999 Gurvaneet S. Randhawa, M.D., Ph.D., Graduate Student A genetic approach to the role of chromatin factors in cancer Principal Research Fellow, University of Luton, UK

1996-2000 Liora Z. Strichman-Almashanu, Ph.D., Graduate Student A novel class of CpG islands – methylated in normal tissues Patent Attorney, Israel

1996-2000 Shan Jiang, M.D., Ph.D., Graduate Student An in vitro model for genomic imprinting using embryonic germ cells President, Innovation Pharmacology, Suzhou, China.

1997-2000 Hengmi Cui, Ph.D., Postdoctoral Fellow Genomic imprinting in cancer Assistant Professor, Johns Hopkins University

1997-2001 Jason Ravenel, Ph.D., Graduate Student Biological role of altered genomic imprinting in cancer

Associate Director, Novartis Institute for Biomedical Research

1998-2003 Patrick O. Onyango, Ph.D., Postdoctoral Fellow Discovery of novel tumor suppressor genes Assistant Professor, Johns Hopkins University

1999-2002 Hiroshi Uejima, Ph.D., Postdoctoral Fellow Genomic imprinting as a novel therapeutic target Section Head, Takeda Pharmaceutical Company, Japan

1999-2004 Stephanie L. Kane, Ph.D., Graduate Student Regulation of genomic imprinting Patent Examiner, US Patent & Trademark Office

1999-2003 Marcia Cruz-Correa, M.D., Ph.D., Postdoctoral fellow Loss of imprinting in colorectal cancer Associate Professor, University of Puerto Rico

2000-2001 Elizabeth Holt, M.D., Ph.D., Postdoctoral Fellow Mouse models of genomic imprinting Assistant Professor, Yale University School of Medicine

2000-2004 James Potash, M.D., Ph.D., Postdoctoral Fellow Imprinted genes in psychiatric disease Associate Professor, Dept. of Psychiatry, Johns Hopkins University

2000-2004 Emily L. Niemitz, Ph.D., Graduate Student Molecular basis of Beckwith-Wiedemann syndrome Senior Editor, Nature Genetics

2000-2006 Richard S. Lee, Ph.D., Graduate Student Novel imprinted gene domains Assistant Professor, Johns Hopkins University

2001-2004 Takashi Sakatani, Ph.D., Postdoctoral Fellow Mouse models of genomic imprinting Assistant Professor, Kobe University School of Medicine, Japan

2003-2007 Hans Bjornsson, M.D., Graduate Student Role of imprinting in human growth Assistant Professor, Johns Hopkins University

2003-2005 Philip Witmer, Graduate Student Epigenetic modifiers in cancer

2004-2008 WenQiang Yu, M.D., Ph.D., Postdoctoral Fellow Genomic imprinting in cancer Assistant Professor, Beijing University

2007-2012 Winston Timp, Ph.D., Postdoctoral Fellow Epigenetics of signaling Assistant Professor, Johns Hopkins University

2004-2008 Atsushi Kaneda, M.D., Ph.D., Postdoctoral Fellow DNA methylation in cancer Associate Professor, Tokyo University

2005-2009 Bo Wen, Ph.D., Postdoctoral Fellow Higher order chromatin function Assistant Professor, Beijing University

2005-2011 Lindsey Brown, Graduate Student Environmental epigenetics

2007-2009 Delphine Fradin, Ph.D., Postdoctoral Fellow Epigenetics of aging Assistant Professor, University of Lyon

2006-2010 Danica Horrell, Graduate Student Epigenetics of Beckwith-Wiedemann syndrome

2006-2009 Christine Ladd-Acosta, Graduate Student High throughput population epigenetics Assistant Professor, Johns Hopkins University

2007-2012 Brian Herb, Graduate Student Epigenetics of development

2007-2012 Akiko Doi, Graduate Student Epigenetics of embryonic stem cells

Postdoctoral Fellow, MIT 2008-2011 Hong Ji, Ph.D., Postdoctoral fellow

Epigenetics of hematopoiesis Assistant Professor, University of Cincinnatti

2009-2012 Oliver McDonald, M.D., Ph.D., Postdoctoral Fellow Epigenetics of EMT Assistant Professor, Vanderbilt University

2009-2012 Kathryn McDougal, Ph.D., Postdoctoral Fellow Epigenetics of aging

2009-2013 Kiran Girreesan Vanaja, Biomedical Engineering PhD Student Effects of imprinting on colon cancer

2010-2012 David Hiller, Ph.D., Postdoctoral Fellow Statistical epigenomics

2010-2015 Namyoung Jung, Graduate Student Developmental epigenetics in model organisms Postdoctoral fellow, Stanford University

2010-2014 Michael Multhaup, Graduate Student Environmental effects on the epigenome

2010-2015 Carolina Montano, MD/PhD Student Mechanism of altered DNA methylation in cancer

2010-2014 Yun Liu, Ph.D., Postdoctoral Fellow Epigenetics of immune development and disease Assistant Professor, Fudan University

2010-2015 Kelly Bakulski, Ph.D., Postdoctoral Fellow Environmental epigenomics Assistant Professor, University of Michigan

2011-Present Elisabet Pujadas, MD/PhD Student Epigenetics of variance

2011-2015 Amy Unterman, MD/PhD Student Epigenetics of aging

2012-2017 Xin Li, Ph.D., Postdoctoral Fellow Genome-epigenome interaction Assistant Professor, Sun Yat-sen University

2013-Present Phillip Wulfridge, Graduate Student Animal models of environmental epigenomics

2014-2016 Garrett Jenkinson, Ph.D., Postdoctoral Fellow Markovian models of epigenomic landscapes Research Investigator, Mayo Clinic

2014-2016 Tal Salz, Ph.D., Postdoctoral Fellow Translational epigenomics of cancer

2014-Present Lindsay Rizzardi, Ph.D., Postdoctoral Fellow Epigenomics of development

2014-Present Varenka Rodriguez, Graduate Student Epigenomics of cancer

2015-Present Brian Mears, Graduate Student Chromatin dynamics of cancer

2015-Present Michael Koldobskiy, M.D., Ph.D., Postdoctoral Fellow Epigenomic evolution of childhood leukemia

2016-Present Emily Lo, BME Graduate student Epigenomic models of tissue development

Selected Invited Lectures

1983 FASEB Conference, "Mechanisms of Carcinogenesis"

1985 NIH Fogarty International Center Conference, "The Chemistry, Biochemistry and Biology of DNA Methylation"

1985 Gordon Research Conference on Cancer 1985 FASEB Conference, "Folate, B12, and One-Carbon Metabolism" 1986 NIH Conference on Colonic Neoplasia 1987 Workshop Chairman, Gordon Research Conference on Cancer 1989 U.S. NIH-Japanese National Cancer Research Institute Cooperative Cancer Research Program,

"Multiple Primary Cancer" 1989 NIEHS Conference, "Critical Target Genes in Chemical Carcinogenesis" 1989 UCLA Keystone Symposium on Molecular & Cellular Biology, "Nucleic Acid Methylation" 1990 NCI/Canada Clinical Trials Group Symposium on Tumour Biology 1990 U.S. NIH-Japanese National Cancer Research Institute Cooperative Cancer Research Program,

"GI Cancer: Subsites at Very High Risk, Epidemiological and Laboratory Aspects" 1990 15th International Cancer Congress, Workshop Co-chairperson, "Role of DNA Methylation in

Development, Differentiation, and Cancer," Hamburg, 1991 Keystone Symposium on Molecular and Cellular Biology, "Genomic Instability and Cancer" 1991 Second International Chromosome 11 Workshop, Paris 1991 U.S. NIH-Japanese National Cancer Research Institute Cooperative Cancer Research Program,

"Molecular Mechanisms in Oncogenesis and Tumor Progression," Hawaii 1991 Sendai International Symposium, "Recent Advances in Cancer Research," Japan 1992 Third International Chromosome 11 Workshop, Salk Institute 1992 Grand Rounds, National Cancer Institute 1993 NIH Inter-Institute Conference on Genomic Imprinting 1993 Twelfth International Congress of Nephrology, Jerusalem 1994 British Society for Cell Biology/British Society for Developmental Biology Annual Meeting,

Edinburgh 1994 Chairman, Symposium on Genomic Imprinting, American Association for Cancer Research Annual

Meeting 1994 Nobel Conference, "Parental Imprinting: Causes and Consequences," Stockholm 1994 World Congress of Gastroenterology 1994 Cold Spring Harbor Symposium on The Genetic Basis of Cancer 1995 Plenary Speaker, Children’s Cancer Group 1995 Keystone Symposium on Molecular and Cellular Biology, "Epigenetic Regulation of Transcription” 1995 Oholo Conference, “Genomic Imprinting and Human Disease,” Oholo, Israel 1995 Second International Conference on Molecular and Clinical Genetics of Childhood Renal Tumors 1995 FASEB Conference, “Biological Effects of DNA Methylation” 1995 AACR Conference, “Cancer: The Interface Between Basic and Applied Research” 1995 Keynote Speaker, University of Nebraska Medical Center, Student Research Forum 1995 Genetics Society of Canada Annual Conference, Guelph, Ontario, Canada 1996 Gordon Research Conference on DNA Alterations in Transformed Cells 1996 Pauline Wilson Homer Symposium on Genetics, Case Western Reserve University 1997 British Society of Developmental Biology, “Mammalian Genetic Imprinting: its Role in Development

and Disease,” Cambridge University 1997 Tenth International Workshop, “Genome-Based Analysis of Gene Regulation and its Evolution,”

International Institute of Genetics and Biophysics, Naples 1997 Symposium on Imprinting Mechanisms and Disease Implications, American Society of Human

Genetics, Baltimore 1998 Keystone Symposium, Epigenetic Regulation of Transcription 1998 Developmental Biology and Cancer Conference at the National Institutes of Health, General Motors

Cancer Research Foundation 1998 Genetically Engineering and Cloning Animals: Science, Society & Industry, Utah State University

Biotechnology Center 1998 Genomic Imprinting and Environmentally Induced Diseases, NIEHS and Duke University 1998 Theodor Boveri Symposium, Genomic Instability in Carcinogenesis – Mechanisms, Detection and

Clinical Relevance, University of Würzburg 1998 The Molecular Medicine Revolution, A New Approach To Understanding And Eliminating Disease,

Nature Medicine and Nature Japan, Tokyo

1999 Ninetieth Annual Meeting of the American Association for Cancer Research, Genetic Imprinting Sunrise Session, Philadelphia

2000 European Society of Human Genetics, Annual Meeting, Amsterdam 2000 Princess Takamatsu Cancer Research Symposium, Tokyo 2001 Genomic Imprinting International Workshop, Japan, Tokyo 2001 Chair, Epigenome Workshop, American College of Medical Genetics Annual Meeting, Miami 2001 Twenty-First Annual Meeting of the American Association for Cancer Research, Cancer Epigenetics

Sunrise Session, New Orleans 2001 American Association for Cancer Research International Conference, Molecular Mechanisms of

Gastrointestinal Cancer, Seoul, Korea 2001 Odyssey Distinguished Lecture, MD Anderson Cancer Center, University of Texas 2002 Co-chair, International Conference on Epigenetic Mechanisms in Human Disease, National Cancer

Institute 2003 Keystone Symposium, Chromatin: Organizing the Genome for Patterns of Gene Expression in

Health and Disease, Big Sky, Montana 2003 Children’s Oncology Group, Dallas 2003 Translational Research in Clinical Oncology Training Program, National Cancer Institute 2003 Grand Rounds, National Cancer Institute 2004 National Cancer Center Research Institute, Foundation for Promotion of Cancer Research, Japan 2004 Immunology/Cell Biology Seminar Series, National Cancer Institute, Frederick 2004 Second Weissenburg Symposium on DNA Methylation, Germany 2004 Cold Spring Harbor Laboratory Symposium on Quantitative Biology 2004 The Jackson Laboratory 45th Annual Short Course in Medical and Experimental Mammalian

Genetics, Bar Harbor 2004 American Society of Human Genetics, Annual Meeting, Toronto 2004 2004 2004

Cold Spring Harbor Laboratory Conference, Identification of Functional Elements in Mammalian Genomes

Harvard Medical School Combined Pathology Grand Rounds Dana-Farber Cancer Institute’s Seminars in Oncology Series

2005 Gordon Research Conference on Cancer Genetics and Epigenetics, Ventura, California 2007 2007 2007

Session Chair, Cold Spring Harbor Meeting, Biology of Genomes Keynote Speaker, Karolinska Institute Cancer Retreat, Djuronaset, Sweden Symposium on Organogenesis, University of Michigan, Ann Arbor

2008 Co-Chair, Keystone Symposium on Cancer Genomics and Epigenomics, Taos 2008 Keynote Speaker, Karolinska Institute Pharmacology Retreat, Djoronaset, Sweden 2009 Nature Miami Winter Symposium, Interpreting the Human Genome, Miami, Florida 2009 50th Anniversary Symposium, Short Course in Human Genetics, Jackson Laboratory, Bar Harbor,

Maine 2009 Karolinska Research Lecture, Nobel Forum, Stockholm, Sweden 2009 What is Life? Lecture, Karolinska Institute, Stockholm, Sweden 2009 Keynote Lecture, Progenitor cells, Microenvironment and Cell Fusion in Cancer Progression,

Djornaset, Sweden 2009 Keynote Lecture, World Congress of Psychiatric Genetics, San Diego 2009 Presidential Lecture, American College of Neuropsychopharmacology, Hollywood, Florida 2009 Evo-Devo Workshop, Wissenschaftskolleg, Berlin, Germany 2010 Sigma-Tau Foundation Lectureship, Rome and Florence, Italy 2010 Nobel Symposium, Karolinska Institute 200th Anniversary, Stockholm, Sweden 2010 Gairdner Foundation, Epigenetics in Development and Disease 2010 Genetics Society UK, Lessons from Cancer for Biology and Genetics 2011 Bernard Langer Lecture, University of Toronto 2011 Keynote Lecture, Biology of Genomes, Cold Spring Harbor Laboratory 2011 Keynote Lecture, Queenstown Molecular Biology Symposium, Queenstown, New Zealand 2011 Keynote Lecture, “A Day with Andy Feinberg Symposium,” Australian Epigenetic Alliance,

Melbourne, Australia 2011 Keynote Lecture, Wellcome Trust Symposium on the Epigenomics of Common Human Disease,

Sanger Center, UK 2011 2011 Discovery Lecturer, Vanderbilt University 2012 Keynote Lecture, Heidelberg Forum for Young Life Scientists

2012 Anderson Memorial Lecture, University of Virginia 2012 Invited Speaker, Folkhalsan Institute of Genetics 50th Anniversary, Helsinki, Finland 2012 Invited Speaker, Karolinska Institute, Stockholm, Sweden 2013 Invited Speaker, Royal Swedish Academy of Sciences, Stockholm, Sweden 2013 Keynote Speaker, FEBS Workshop on Translating Epigenomes into Function, Capri, Italy 2013 Invited Speaker, 25th Anniversary Symposium, University of Michigan Cancer Center 2014 Invited Speaker, Future of Genomic Medicine VII, Scripps Institute, La Jolla 2014 Invited Speaker, Miami Winter Symposium on Neuroscience, UMiami/Nature 2014 Presidential Seminar, Memorial Sloan-Kettering Cancer Center, New York 2014 Lineberger Lecture, University of North Carolina Cancer Center 2014 Invited Speaker, University of Michigan Life Sciences Discoverers’ Symposium 2014 Keynote Speaker, Nature/Guangzhou Institute Symposium on Cancer and the Nucleus 2014 Invited Speaker, Gairdner Foundation Symposium, Ottawa 2014 Invited Speaker, NIH Director’s Lecture Series 2015 Genome Pioneer Lecture, Texas A&M University 2015 Keynote Speaker, Gordon Research on Genome Architecture in Cell Fate & Disease,

Hong Kong 2015 Invited Speaker, Nobel Symposium on Epigenetics of Disease, Stockholm 2015 Keynote Speaker, Marabou Conference on Nutrition, Stockholm 2015 Klaus Hofmann Lecture, University of Pittsburgh 2016 Keynote Speaker, American Association of Clinical Chemistry Annual Meeting 2016 Keynote Speaker, Environmental Mutagenesis and Genomics Society Annual Meeting 2016 Invited Speaker, St. Jude's Biomedical Symposium 2016 Keynote Speaker, PMPPC International Conference, Barcelona 2016 Invited Speaker, Huntsman Cancer Institute, University of Utah 2017 Keynote Speaker, Stem Cell Crossroads, Cold Spring Harbor Asia, Suzhou, China 2017 Keynote Speaker, Cancer Epigenome Workshop, Karolinska Institute, Stockholm 2017 Keynote Lecture, Epigenomics of Human Disease, Karolinska Institute 2018 Invited Speaker, Gordon Conference on Epigenetics and Metabolism, Hong Kong 2018 Invited Speaker, Conference on Computational Epigenomics, Chinese Academy of Sciences,

Shanghai 2018 Invited Speaker, NCI Workshop on Evolutionary Dynamics