Publikationsliste Dieter Hoppe 1969-2010 · Synthesis of 2-Alkylidene-cycloalkane-1,3-diols via Enantioselective Intramolecular Carbolithiation, Tetrahedron Lett. 2003, 44, 8979-8982

2010

T. Hemery, R. Hünerbein, R. Fröhlich, S. Grimme, D. Hoppe,

Configurationally Labile Enantioenriched Lithiated 3-Arylprop-2-enyl Carbamates: Joint

Experimental and Quantum Chemical Investigations on the Equilibrium of Epimers,

J. Org. Chem. 2010, 75, 5716-5720.

S. Kollmann, E. Nauha, D. Hoppe,

Highly Stereoselective De-Novo Synthesis of Protected 2-Amino-3-C-methyl-2,3-dideoxy-D-

altrose,

Tetrahedron 2010, 66, 6162-6166.

T. Hemery, J. Becker, R. Fröhlich, D. Hoppe,

(−)-Myrtenyl N,N-Diisopropylcarbamate: Stereochemistry of Lithiation and Electrophilic

Substitution Directed by Dynamic Kinetic Diastereoisomer Resolution,

Eur. J. Org. Chem. 2010, 3711-3720.

S. Kollmann, R. Fröhlich, D. Hoppe,

Highly Stereoselective Synthesis of 2-Amino-3-C-methyl-2,3-dideoxyaldoses by C3-Chain

Elongation via Homoaldol Reaction of Sugar Aldehydes,

Synthesis 2010, 749-756.

T. Hemery, B. Wibbeling, R. Fröhlich, D. Hoppe,

Stereoselective Synthesis of Highly Substituted Annulated Dihydropyrans Based on γ-Lithiation

and Homoaldol Reaction of an Enantiopure α-Silylated Vinyl Carbamate,

Synthesis 2010, 329-342.

2009

Y.-L. Chen, D. Hoppe,

1-(N,N-Diisopropylcarbamoyloxy)-1-tosyl-1-alkenes-a2d1 Synthons via Tandem Umpolung,

J. Org. Chem. 2009, 74, 4188-4194.

Y.-L. Chen, D. Hoppe,

Copper-catalyzed asymmetric conjugate addition of Grignard reagents to 1-(N,N-diisopropyl-

carbamoyloxy)-1-tosyl-1-alkenes,

Tetrahedron: Asymmetry 2009, 20, 1561-1567.

Y.-L. Chen, R. Fröhlich, D. Hoppe,

Copper-catalyzed Asymmetric Addition of Et2Zn to 2-Cyclohexen-1-one and 2-Carbamoyloxy-2-

cyclohexen-1-one with Phosphoramidite, Phosphite, and Bidentate Phosphite-oxazoline Ligands,


D. Hoppe,

α-Metallated O-2-Alkenyl Carbamates: Synthetic Equivalents of Chiral Homoenolates and

Materials for Asymmetric Homoaldol Reaction,

Synthesis 2009, 43-61.

2008

E.-U. Würthwein, D. Hoppe,

Enantiotopos-Differentiating (−)-Sparteine-Mediated γ-Deprotonation of 1-Alkenyl Carbamates:

DFT Calculations Verify the Observed Stereoselectivity,

J. Org. Chem. 2008, 73, 9055-9060.

H. Lange, R. Fröhlich, D. Hoppe,

Cu(I)-Catalyzed Stereospecific Coupling Reactions of Enantioenriched α-Stannylated Benzyl

Carbamates and Their Application,

Tetrahedron 2008, 64, 9123-9135.

H. Lange, R. Hünerbein, B. Wibbeling, R. Fröhlich, S. Grimme, D. Hoppe,

Comprehensive Experimental and Theoretical Studies of Configurationally Labile Epimeric

Diamine Complexes of α−Lithiated Benzyl Carbamates,

Synthesis 2008, 2905-2918.

M. Siemer, R. Fröhlich, D. Hoppe,

Asymmetric Synthesis of 3,4-Annulated Cyclopentenones from Cycloalkenyl Ketones and Vinyl

Carbamates by Diastereoselective Carbonyl Addition/Conrotatory 4π Ring Closure,

Synthesis 2008, 2264-2270.

J. Becker, K. Bergander, R. Fröhlich, D. Hoppe,

Asymmetric Total Synthesis and X-Ray Crystal Structure of the Cytotoxic Marine Diterpene (+)-

Vigulariol,

Angew. Chem. 2008, 120, 1678-1681; Angew. Chem. Int. Ed. 2008, 47, 1654-1657.

S. Wünnemann, R. Fröhlich D. Hoppe,

Asymmetric Strecker Reaction of N-Benzhydrylimines Utilising New Tropos Biphenyldiol-Based

Ligands,

Eur. J. Org. Chem. 2008, 684-692.

H. Lange, R. Hünerbein, R. Fröhlich, S. Grimme, D. Hoppe,

Configurationally Labile Lithiated O-Benzyl Carbamates: Application in Asymmetric Synthesis and

Quantum Chemical Investigations on the Equilibrium of Diastereomers,

Chem. Asian J. 2008, 3, 78-87.

H. Lange, K. Bergander, R. Fröhlich, S. Kehr, S. Nakamura, N. Shibata, T. Toru, D. Hoppe,

Highly Enantioselective Reactions of Configurationally Labile Epimeric Diamine Complexes of

Lithiated S-Benzyl Thiocarbamates,

Chem. Asian J. 2008, 3, 88-101.

2007

R. Otte, B. Wibbeling, R. Fröhlich, S. Nakamura, N. Shibata, T. Toru, D. Hoppe,

Asymmetric lithiation of 2-alkynyl aryl sulfides - Enantio- and diastereoselective formation of

allenyl aryl sulfides and their application in nickel-catalyzed cross-coupling reactions,

Tetrahedron Lett. 2007, 48, 8636-8642.

D. Hoppe, L. Padeken, K. Gottschalk, W. Guarnieri, R. Fröhlich,

Synthesis of (−)-N-Acetyl-slaframine by C-1, C-5 Bis-hydroxyalkylation of (S)-2-(N,N-

Dibenzylamino)-1,5-pentanediol via Highly Diastereoselective Lithiation of the Dicarbamate,

Synthesis 2007, 1984-1994.

J. Becker, R. Fröhlich, O. Kataeva, D. Hoppe,

Stereoselective Synthesis of Hexahydro-isobenzofuran-4(1H)-ones from Chiral Substituted

Cyclohex-2-enyl Carbamates via Asymmetric Homoaldol Reaction and THF Cyclocondensation,

Eur. J. Org. Chem. 2007, 3349-3364.

J. Becker, R. Fröhlich, K. Salorinne, D. Hoppe,

Asymmetric Homoaldol Reactions with Cyclohex-2-enyl N,N-Diisopropylcarbamate: Kinetic

Resolution, Elucidation of the Stereochemical Course and Applications in the Synthesis of

Hexahydroisobenzofuran-4-(1H)-ones,

Eur. J. Org. Chem. 2007, 3337-3348.

R. Bou Chedid, R. Fröhlich, B. Wibbeling, D. Hoppe,

Enantioselective γ-Deprotonation of Alkyl-Substituted O-1,3-Butadien-2-yl Carbamates and

Regioselective Asymmetric Homoaldol Reaction,

Eur. J. Org. Chem. 2007, 3179-3190.

R. P. Sonawane, C. Mück-Lichtenfeld, R. Fröhlich, K. Bergander, D. Hoppe,

Highly Diastereoselective Lithiation and Substitution of an (S)-Prolinyl Thiocarbamate via

Sterically Homogeneous Litio(thiocarbamate): Synthesis of Enantiomerically Pure Prolinethiols,

Chem. Eur. J. 2007, 1847-1854.

S. Kollmann, R. Fröhlich, D. Hoppe,

Chain-Elongation of Sugar Aldehydes by Asymmetric Homoaldol Reaction: Introduction of a

Functionalized 3-Methyl-Substituted Three-Carbon Unit,

Synthesis 2007, 883-892.

R. Bou Chedid, M. Brümmer, B. Wibbeling, R. Fröhlich, D. Hoppe,

Stereo- and Regiochemical Divergence in the Substitution of a Lithiated Alk-1-en-3-yn-2-yl

Carbamate: Synthesis of Highly Enantioenriched Vinylallenes or Alk-3-en-5-yn-1-ols,

Angew. Chem. Int. Ed. 2007, 46, 3131-3134; Angew. Chemie 2007, 119, 3192-3195.

J. Becker, S. Grimme, R. Fröhlich, D. Hoppe,

Estimation of the Kinetic Acidity from Substrate Conformation – Stereochemical Course of the

Deprotonation of Cyclohexenyl Carbamates,

Angew.Chem. Int. Ed. 2007, 46, 1645-1649; Angew. Chem. 2007, 119, 1672-1676.

D. Hoppe,

Asymmetric Homoaldol Reactions, in Asymmetric Synthesis – The Essentials (Eds. M. Christmann,

S. Bräse), p. 100-104, Wiley-VCH, 2007.

2006

G. Christoph, C. Stratmann, I. Coldham, D. Hoppe,

Asymmetric Synthesis of 3-Hydroxy-pyrrolidines via Tin-Lithium Exchange and Cyclization,

Org. Lett. 2006, 8, 4469-4471.

R. P. Sonawane, R. Fröhlich, D. Hoppe,

Highly Enantioselective Reactions of a Lithiated α-Thioallyl Carbanion via Thermodynamic

Resolution Pathway,

Adv. Synth. Catal. 2006, 348, 1847-1854.

A. Brüns, B. Wibbeling, R. Fröhlich, D. Hoppe,

Enantio- and Diastereoselective Synthesis of Tetrahydrofurochromenes via Sequential Asymmetric

Homoaldol Reaction and a Mukaiyama-Type Tetrahydrofuran Cyclization,

Synthesis 2006, 3111-3121.

R. Kalkofen, D. Hoppe,

First Example of an Enantiospecific sp3-sp2 Stille Coupling of a Chiral Allylstannane with Aryl

Halides,

Synlett 2006, 1959-1962.

R. P. Sonawane, R. Fröhlich,

D. Hoppe, Highly Diastereoselective Formation and Reactions of a Non-Mesomerically Stabilized,

Lithiated α-Thiocarbanion,

Chem. Commun. 2006, 3101-3103.

R. Bou Chedid, R. Fröhlich, D. Hoppe,

Asymmetric γ-Deprotonation and Homoaldol Reaction of 1,3-Dien-2-yl Carbamates: Stereo- and

Regiochemistry,

Org. Lett. 2006, 8, 3061-3064.

S. Wünnemann, R. Fröhlich, D. Hoppe,

3,3’-Oxazolidinyl-Substituted 2,2’-Biphenyldiols: Novel Tropos Ligands with a Large Induction on

the Chiral Axis,

Org. Lett. 2006, 8, 2455-2458.

M. Kauch, D. Hoppe,

Synthesis of Halogenated Phenols by Directed ortho-Lithiation and ipso-Iododesilylation Reactions

of O-Aryl N-Isopropylcarbamates,

Synthesis 2006, 1578-1590.

M. Kauch, D. Hoppe,

Efficient Two-Step Synthesis of Salicylaldehydes via Directed ortho-Lithiation of in situ N-

Silylated O-Aryl N-Isopropylcarbamates,

Synthesis 2006, 1575-1578.

2005

S. Brandau, D. Hoppe,

Asymmetric Synthesis of (2-Carbamoyloxy-1-alkenyl)cyclopropanes by Intramolecular

Cycloalkylation,

Tetrahedron 2005, 61, 12244-12255.

M. M. Martinez, D. Hoppe,

Total Synthesis of (−)-α-Kainic Acid by (−)-Sparteine-Mediated Asymmetric

Deprotonation/Cycloalkylation,

Proceedings of ECSOC-9, International Electronic Conference on Synthetic Organic Chemistry,

9th, Nov. 1-30, 2005 (2005), CD-ROM Edition, A012/1-A012/4. Publisher: Molecular Diversity

Preservation International, Basel, Switzerland.

R. Kalkofen, S. Brandau, S. Ünaldi, R. Fröhlich, D. Hoppe,

Enantio- and Diastereoselective Synthesis of Highly Substituted Acylcyclopropanes from

Homoaldol Products via Stereospecific Homoallylic Cyclization,

Eur. J. Org. Chem. 2005, 4571-4580.

S. Ünaldi, R. Fröhlich, D. Hoppe,

Synthesis of Enantioenriched and Diastereomerically Pure, cis-Fused a-Oxy-Substituted γ-Lactones

via Epoxidation of Optically Active Homoaldol Products,

Synthesis 2005, 2507-2520.

M. Özlügedik, S. Ünaldi, B. Wibbeling, D. Hoppe,

Synthesis of Enantioenriched, trans-Fused Bicyclo[4.4.0]dec-3-enes and Bicyclo[4.3.0]non-3-enes ,

Bearing a 1,5-Lactone Bridge,

Adv. Synth. Catal. 2005, 347, 1627-1631.

S. Ünaldi, M. Özlügedik, R. Fröhlich, D. Hoppe,

Diastereoselective Synthesis of Enantioenriched, Annulated Tetrahydrofurans by Simultaneous

Formation of the O-1-C-5 and the C-5-C-4 Bonds,

Adv. Synth. Catal. 2005, 347, 1621-1626.

R. Otte, R. Fröhlich, B. Wibbeling, D. Hoppe,

Solid-State Structure and Enantioselective Reaction of a 1-Thio-Substituted Propargyllithium-(−)-

Sparteine Complex,

Angew. Chem. Int. Ed. 2005, 44, 5492-5496; Angew. Chem. 2005, 117, 5629-5632.

M. Kauch, V. Snieckus, D. Hoppe,

Substitution of Hydroxybiaryls via Directed ortho-Lithiation of O-Aryl N-Isopropyl-N-silyl-

carbamates,

J. Org. Chem. 2005, 70, 7149-7158.

S. Brandau, R. Fröhlich, D. Hoppe,

Formation of 1-Methylene-2-vinylcyclopropane by Intramolecular SE’-Cycloalkylation Reaction,


J. Reuber, R. Fröhlich, D. Hoppe,

Asymmetric γ-Deprotonation and Substitution Reactions of (Z)-1,3-Diphenyl-1-propenyl N,N-

Diisopropylcarbamate,

Eur. J. Org. Chem. 2005, 3017-3025.

E.-U. Würthwein, D. Hoppe,

Enantioselective Deprotonation of O-Alkyl and O-Alk-2-enyl Carbamates in the Presence of (−)-

Sparteine and (−)-α-Isosparteine. A Theoretical Study,

J. Org. Chem. 2005, 70, 4443-4451.


Novel Approach to the (−)-Sparteine-Mediated Synthesis of Kainoids: Total Synthesis of (−)-α-

Kainic Acid via (−)-Sparteine-Mediated Deprotonation,

Eur. J. Org. Chem. 2005, 1427-1443.

W. Zeng, R. Fröhlich, D. Hoppe,

Enantioselective, (−)-Sparteine-Mediated Deprotonation of Geranyl and Neryl N,N-

Diisopropylcarbamate: Configurational Stability of the Intermediate Lithium Compounds,

Tetrahedron 2005, 61, 3281-3287.

N. Gudimalla, R. Fröhlich, D. Hoppe,

A Simple and Practical Approach to α-Halo- and α-Phenylthio-α,β-Enones,

Synthesis 2005, 415-418.

E. Beckmann, D. Hoppe,

Synthesis of an Enantioenriched α-Carbamoyloxy-crotylboronate and its Homoaldol Reaction with

Aldehydes,

Synthesis 2005, 217-222.

2004

E. Beckmann, V. Desai, D. Hoppe,

Stereospecific Reaction of α-Carbamoyloxy-2-alkenylboronates and α-Carbamoyloxy-

alkylboronates with Grignard Reagents − Synthesis of Highly Enantioenriched Secondary Alcohols,

Synlett 2004, 2275-2280.

N. Gudimalla, R. Fröhlich, D. Hoppe,

Stereoselective Synthesis of Baylis-Hillman-Type Adducts via Allenolates Generated by Acyl

Migration,

Org. Lett. 2004, 6, 4005-4008.


Enantioselective Total Synthesis of (−)-α-Kainic Acid,

Org. Lett. 2004, 6, 3743-3746.

M. Özlügedik, J. Kristensen, J. Reuber, R. Fröhlich, D. Hoppe,

Stereoselective Synthesis of Highly Substituted Bicyclic γ-Lactones Using Homoaldol Addition of

1-(1-Cycloalkenyl)methyl Carbamates,

Synthesis 2004, 2303-2316.

R. Kalkofen, S. Brandau, B. Wibbeling; D. Hoppe,

Simultaneous Enolate Generation and Hydroxy Group Activation by Acyl Migration – Synthesis of

Stereohomogeneous Cyclopropane Carboxaldehydes and Acylcyclopropanes by Cycloalkylation of

4-Hydroxy-1-alkenyl Carbamates,


M. Zimmermann, B. Wibbeling, D. Hoppe,

Synthesis of Enantiomerically and Diastereomerically Pure 4-Hydroxy-1,2-alkadienyl Carbamates

and Their Application in a Modified Nazarov Cyclization Towards Chiral Cyclopentenones,

Synthesis 2004, 765-774.

J. Reuber, R. Fröhlich, D. Hoppe,

Highly Enantioenriched Homoenolate Reagents by Asymmetric γ-Deprotonation of Achiral 1-Silyl-

Substituted 1-Alkenyl Carbamates,

Org. Lett. 2004, 6, 783-786.

M. Seppi, R. Kalkofen, J. Reupohl, R. Fröhlich, D. Hoppe,

Highly Enantiomerically Enriched Ketone Homoenolate Reagents Prepared by (−)-Sparteine-

Mediated γ-Deprotonation of Achiral 1-Alkenyl Carbamates,

Angew. Chem. Int. Ed. 2004, 43, 1423-1427; Angew. Chem. 2004, 116, 1447-1451.

G. Christoph, D. Hoppe,

Asymmetric Deprotonation with Alkyllithium/(−)-Sparteine,

Review in The Chemistry of Functional Groups (Hrsg. Z. Rappoport, I. Marek), 2004, Interscience

Publishers, Wiley & Sons, 1058-1164.

2003

G. Gralla, B. Wibbeling, D. Hoppe,

Synthesis of 2-Alkylidene-cycloalkane-1,3-diols via Enantioselective Intramolecular

Carbolithiation,


F. Marr, M. Brüggemann, D. Hoppe,

Enantioselective Synthesis by Lithiation Adjacent to Oxygen and Electrophile Incorporation,

Review in Topics in Organometallic Chemistry Vol. 5 (Hrsg. D. M. Hodgson), 2003, Springer-

Verlag, p. 61-138.

C. Schultz-Fademrecht, M. Zimmermann, R. Fröhlich, D. Hoppe,

Synthesis of Enantiopure 2,5-Dihydro-3-iodofurans and Substituted 3-Iodofurans by

Iodocyclization of 4-Hydroxy-1,2-alkadienyl Carbamates,

Synlett 2003, 1969-1972.

2002

F. Marr, D. Hoppe,

Synthesis of Enantiomerically Enriched Tertiary 2-Cyclohexene-1-thiols via Configurationally

Stable α-Thio-Substituted Allyllithium Compounds,

Org. Lett. 2002, 4, 4217-4220.

F. Marr, R. Fröhlich, D. Hoppe,

Preparation of meso-1,3-Diphenylallyllithium/(−)-Sparteine Complex - Its Crystal Structure and

Reactions,


F. Marr, R. Fröhlich, B. Wibbeling, C. Diedrich, D. Hoppe,

The Synthesis and Configurational Stability of Enantioenriched α-Thioallyllithium Compounds and

the Stereochemical Course of Their Electrophilic Substitutions,

Eur. J. Org. Chem. 2002, 2970-2988.

G. Christoph, D. Hoppe,

Asymmetric Synthesis of 2-Alkenyl-1-cyclopentanols via Tin-Lithium Exchange and

Intramolecular Cycloaddition,

Org. Lett. 2002, 4, 2189-2192.

G. Gralla, B. Wibbeling, D. Hoppe,

Synthesis of an Ethynyl Carbamate and Application for the Enantioselective Cyclocarbolithiation,

Org. Lett. 2002, 4, 2193-2195.

C. Schultz-Fademrecht, M. A. Tius, S. Grimme, B. Wibbeling, D. Hoppe,

Synthesis of Enantioenriched 5-Alkylidene-2-cyclopentenones from Chiral Allenyl Carbamates:

Generation of a Chiral Lithium Allenolate and Allylic Activation for a Conrotatory 4π-

Electrocyclization,


J. G. Peters, M. Seppi, R. Fröhlich, B. Wibbeling, D. Hoppe,

Stereoselective Intermolecular Carbolithiation of Open-Chain and Cyclic 1-Aryl-1-alkenyl N,N-

diisopropylcarbamates Coupled with Electrocyclic Substitution. Observation of p-Carboxylation in

a Benzyllithium Derivative,

Synthesis 2002, 381-392.

M. Özlügedik, J. Kristensen, B. Wibbeling, R. Fröhlich, D. Hoppe,

Nonracemic, Chiral Homoenolate Reagents Derived from (Cycloalk-1-enyl)methyl Carbamates and

Evaluation of Their Configurational Stabilities,

Eur. J. Org. Chem. 2002, 414-427.

M. Brüggemann, R. Fröhlich, B. Wibbeling, C. Holst, D. Hoppe,

Stereoselective Formation of Quarternary Carbon Centres with Chiral 3-Sulfonyl-1,3-oxazolidines

and Titanium Enolates,

Tetrahedron 2002, 58, 312-340.

A. Deiters, C. Mück-Lichtenfeld, R. Fröhlich, D. Hoppe,

Planar-Chiral (2E,7Z)- and (2Z,7E)-Cyclonona-2,7-dien-1-yl Carbamates by Asymmetric Bis-

Allylic α,α'-Cycloalkylation - Studies on Their Conformational Stability,

Chem. Eur. J. 2002, 8, 1833-1842.

2001

D. Hoppe, B. J. Morgan, M. C. Kozlowski,

(−)-Sparteine, e-EROS Encyclopedia of Reagents for Organic Synthesis 2001.

D. Hoppe,

1-(Benzyloxymethoxy)propyllithium, e-EROS Encyclopedia of Reagents for Organic Synthesis

2001.

D. Hoppe,

(E)-1-(N,N-Diisopropylcarbamoyloxy)crotyllithium, e-EROS Encyclopedia of Reagents for Organic

Synthesis 2001.

M. Kauch, D. Hoppe,

Synthesis of Substituted Phenols by Directed ortho-Lithiation of in situ N-Silyl-Protected O-Aryl-

N-monoalkylcarbamates,

Can. J. Chem. 2001, 79, 1736-1746.

M. Oestreich, D. Hoppe,

Stereospecific Preparation of Highly Enantiomerically Enriched Organomagnesium Reagents,

Chemtracts - Organic Chemistry 2001, 14, 100-105.

A. Deiters, D. Hoppe,

Asymmetric Synthesis of cis-1,2-Dialkenyl-Substituted Cyclopentanes via (−)-Sparteine-Mediated

Lithiation and Cycloalkylation of a 9-Chloro-2,7-nonadienyl Carbamate,

J. Org. Chem. 2001, 66, 2842-2849 .

C. Schultz-Fademrecht, B. Wibbeling, R. Fröhlich, D. Hoppe,

Synthesis of Enantiomerically Enriched Allenes by (−)-Sparteine-Mediated Lithiation of Alkynyl

Carbamates,

Org. Lett. 2001, 3, 1221-1224.

H. Laqua, R. Fröhlich, B. Wibbeling, D. Hoppe,

Synthesis of Enantioenriched Indene-Derived Bicyclic Alcohols and Tricyclic Cyclopropanes via

(−)-Sparteine-Mediated Lithiation of a Racemic Precursor and Kinetic Resolution During the

Cyclocarbolithiation,

J. Organomet. Chem. 2001, 96-104.

A. Deiters, B. Wibbeling, D. Hoppe,

Enantio- and Diastereoselective Synthesis of a 3,4-Divinylpyrrolidine via Asymmetric

Deprotonation and Cyclization of a 9-Chloro-5-aza-2,7-nonadiene,

Adv. Synth. Catal. 2001, 181-183.

M. Brüggemann, C. Holst, D. Hoppe,

First Enantioselective Total Synthesis of Both (+)- and (−)-Metachromin A,

Eur. J. Org. Chem. 2001, 647-654.

O. Stratmann, B. Kaiser, R. Fröhlich, O. Meyer, D. Hoppe,

Configurational Stability of an Enantioenriched α-Thiobenzyllithium Derivative and

Stereochemical Course of Its Electrophilic Substitution Reactions. Synthesis of Enantiomerically

Pure Tertiary Benzylic Thiols,

Chem. Eur. J. 2001, 423-435.

2000

O. Stratmann, D. Hoppe, R. Fröhlich,

Synthesis and Structure of Highly Enantio- and Diastereoenriched 1-Aza-4-oxa-7-

thiabcyclo[3.3.0]octan-8-ones Derived from Acyl-Substituted S-Benzyl Thiocarbamates,

J. Prakt. Chem. 2000, 342, 828-831.

A. Kreier, R. Fröhlich, E. Wegelius, D. Hoppe,

Asymmetric Synthesis of Stereodefined 7-(Alk-1-enyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic

Acids and Their Precursors, Bearing a Polar Group in 8-Position, by the 3-Sulfonyl-1,3-oxazolidine

Method,

Synthesis 2000, 1391-1402.

A. Deiters, R. Fröhlich, D. Hoppe,

Enantioselective Synthesis of Functionalized 1,5-Cyclononadienes by Intramolecular

Cycloalkylation by Means of α,α-Diallylcoupling,

Angew. Chem. 2000, 112, 2189-2192; Angew. Chem. Int. Ed. Engl. 2000, 39, 2105-2107.

A. Deiters, C. Mück-Lichtenfeld, R. Fröhlich, D. Hoppe,

Asymmetric Synthesis of a (2Z,7E)-Cyclononadiene by an Intramolecular Cycloalkylation and

Insights to Its Conformational Properties,

Org. Lett. 2000, 2, 2415-2418.

D. Heimbach, R. Fröhlich, B. Wibbeling, D. Hoppe,

Asymmetric Lithiation of an Allyl Carbamate by an Complexing Remote Chiral Substituent,

Synlett 2000, 950-954.

K. R. K. Prasad, D. Hoppe,

Applications of Homoallylic Alcohols Derived from (−)-Sparteine-Mediated Asymmetric

Homoaldolization: Entry to 5- to 8-Membered Oxacycles through Metathesis Reaction,

Synlett 2000, 1067-1069.

F. Steif, B. Wibbeling, O. Meyer, D. Hoppe,

Enantio- and Diastereoselective Synthesis of (Protected) 2-Formyl- and 2-(Hydroxymethyl)-1-

phenyl-1,3-alkanediols from Chiral 2-Methoxy-3-tosyl-1,3-oxazolidines by Subsequent

Asymmetric Formylation and Aldolization,

Synthesis 2000, 743-753.

C. Redecker, U. Altrup, D. Hoppe, R. Düsing, E.-J. Speckmann,

Effects of Valproate Derivatives: I. Antiepileptic Efficacy of Amides, Structural Analogs and

Esters,

Neuropharmacology 2000, 39, 254-266.

C. Redecker, U. Altrup, D. Hoppe, T. Hense, A. Kreier, A. Rabe, R. Düsing, E.-J. Speckmann,

Effects of Valproate Derivatives: II. Antiepileptic Efficacy in Relation to Chemical Structures of

Valproate Sugar Esters,

Neuropharmacology 2000, 39, 267-281.

1999

M. Oestreich, D. Hoppe,

(−)-Sparteine-Mediated Stereoselective Intramolecular Conjugate Addition Reactions of Dienes and

Enynes,


A. Deiters, D. Hoppe,

Chiral Induction by Elimination-Coupled Lithium-Ene Reaction: Synthesis of (+)-(3R, 4R)-1,2-

Dihydromultifidene,


J. van Bebber, H. Ahrens, R. Fröhlich, D. Hoppe,

Efficient Desymmetrization of meso-cis-1,2-Cyclohexanedimethanol with Differentiation between

Diastereotopic and Enantiotopie C-H Bonds by (−)-Sparteine-Mediated Deprotonation,

Chem. Eur. J. 1999, 5, 1905-1916.

J. Schwerdtfeger, S. Kolczewski, B. Weber, R. Fröhlich, D. Hoppe,

Stereoselective Deprotonation of Chiral and Achiral 2-Aminoalkyl Carbamates. Synthesis of

Optically Active β-Aminoalkanols via 1-Oxy-Substituted Alkyllithium Intermediates,

Synthesis 1999, 1573-1592.

B. Weber, S. Kolczewski, R. Fröhlich, D. Hoppe,

Facile and Highly Stereoselective Synthesis of the C2-Symmetrical Diamino Diol Core-Unit of

HIV-1 Protease Inhibitors and of Their Symmetrical and Unsymmetrical Analogues from Lithiated

2-(Dibenzylamino)alkyl Carbamates Oxidative Dimerization,

Synthesis 1999, 1593-1606.

E.-U. Würthwein, K. Behrens, D. Hoppe,

Enantioselective Deprotonation of Alkyl Carbamates by Means of (R,R)-1,2-Bis(N,N-

dimethylamino)cyclohexane/sec-Butyllithium - Theory and Experiment,

Chem. Eur. J. 1999, 5, 3459-3463.

T. Heinl, S. Retzow, D. Hoppe, G. Fraenkel, A. Chow,

Experimental and Theoretical Investigations of Lithio-Indenyl Carbamate/(–)-Sparteine and (–)-α-

Isosparteine Complexes,

Chem. Eur. J. 1999, 5, 3464-3470.

B. Weber, J. Schwerdtfeger, R. Fröhlich, A. Göhrt, D. Hoppe,

Diastereoselective Lithiation and Substitution of (S)-N-Benzylprolinol and rac-N-Benzylpiperidine-

2-methanol via the Carbamate Esters. Kinetic Resolution by means of (−)-Sparteine-mediated

Deprotonation,

Synthesis 1999, 1915-1924.

C. Derwing, H. Frank, D. Hoppe,

Chiral Benzyllithium Compounds: High Configurative Stability of (R)- and (S)-1-Lithioindan-1-yl

N,N-Diisopropylcarbamate and Unexpected Stereochemical Course of the Substitution Reactions,

Eur. J. Org. Chem. 1999, 3519-3524.

D. Hoppe, M. J. Woltering, M. Oestreich, R. Fröhlich, (−)-Sparteine-mediated Asymmetric

Intramolecular Carbolithiation of Alkenes – Synthesis of Enantiopure Cyclopentanes with Three

Consecutive Stereogenic Centers, Helv. Chim. Acta 1999, 82, 1860-1877.

M. Oestreich, R. Fröhlich, D. Hoppe,

(−)-Sparteine-mediated Stereoselective Intramolecular Carbolithiation of 4-Substituted 5-Hexynyl

Carbamates. Synthesis of Enantiopure 1,3-Difunctionalized Alkylidene Cyclopentanes,

J. Org. Chem. 1999, 64, 8616-8626.

S. H. Kleinfeld, E. Wegelius, D. Hoppe,

(−)-Sparteine-Mediated Asymmetric Cyclocarbolithiation of Alkenes Combined with a

Stereospecific Retro-[1,4]-Brook-Rearrangement,

Helv. Chim. Acta, 1999, 82, 2413-2424.

F. Marr, R. Fröhlich, D. Hoppe,

A Highly Enantioenriched, Configurationally Stable α-Thioallyllithium Compound and the

Stereochemical Course of Its Electrophilic Alkylation,

Org. Lett. 1999, 1, 2081-2084.

1998

M. Oestreich, R. Fröhlich, D. Hoppe,

(−)-Sparteine-Mediated Stereoselective Intramolecular Carbolithiation of Alkynes,


M. J. Woltering, R. Fröhlich, B. Wibbeling, D. Hoppe,

Stereoselective Synthesis of Hydroxylated Indolizidines via (−)-Sparteine Mediated Kinetic

Resolution Coupled with Intramolecular Carbolithiation,

Synlett 1998, 797-800.

E. Winter, D. Hoppe,

A New Route to the Asymmetric Synthesis of (−)-Malyngolide and (−)-epi-Malyngolide Using N-

Sulfonyl-1,3-oxazolidines as Chiral Auxiliaries,

Tetrahedron 1998, 54, 10329-10338.

W. Guarnieri, M. Sendzik, R. Fröhlich, D. Hoppe,

Regio- and Stereoselective Lithiation and C-Substitution of (S)-2-(Dibenzyl-amino)butane-1,4-diol

via Dicarbamates,

Synthesis 1998, 1274-1286.

M. Sendzik, W. Guarnieri, D. Hoppe,

Monocarbamates, Derived from (S)-2-Dibenzylamino)-1,4-diol, and the Influence of the Second O-

Protecting Group on the Regioselectivity of Deprotonation – Application to the Synthesis of the

Boletus Toxin (2S,4S)-γ-Hydroxy-norvaline,

Synthesis 1998, 1287-1297.

K. Behrens, R. Fröhlich, O. Meyer, D. Hoppe,

Enantioselective Lithiation and Substitution of (E)-Cinnamyl N,N-Diisopropyl-carbamate through

Use of (−)-Sparteine Complexes,

Eur. J. Org. Chem. 1998, 2397-2403.

1997

C. Boie, D. Hoppe,

Stereoselective Synthesis of Enantiopure β-Amino Alcohols via Nucleophilic β-Amino-α-

hydroxyalkylation by Means of 1-Lithiated 2-[N-(Diphenyl-methyleneamino)]alkyl Carbamates,

Synthesis 1997, 176-182.

D. Hoppe, P. Tebben, M. Reggelin, M. Bolte,

Highly Diastereoselective, Nucleophilic Alkenoylation of Enantiopure α-Oxy- and α-

Aminoalkanals by Lithiated [1-(p-Toluenesulfonyl)alk-2-enyl] Carbamates. Revision of the

Stereochemistry and Application to the Synthesis of a Dihydroxyethylene Dipeptide Isostere,

Synthesis 1997, 183-190.

M. J. Woltering, R. Fröhlich, D. Hoppe,

Synthesis of Enantio- and Diastereopure Cyclopentanols by Asymmetric Cyclocarbolithiation of 5-

Alkenyl Carbamates,


D. Hoppe, B. Kaiser, O. Stratmann, R. Fröhlich,

A Highly Enantiomerically Enriched α-Thiobenzyllithium Derivative with Unusual Configurational

Stability,

Angew. Chem. 1997, 109, 2872-2874, Angew. Chem. Int. Ed. Engl. 1997, 36, 2784-2786.

D. Hoppe, T. Hense,

Convenient Synthesis of Enantiomerically Enriched β-Cyclopropyl-alaninol Derivatives by Kinetic

Resolution via (−)-Sparteine-Mediated Deprotonation,

Synthesis 1997, 1394-1398.

D. Hoppe, T. Hense,

Enantioselective Synthesis with Lithium/(−)-Sparteine Carbanion-Pairs (Review),


D. Hoppe, The Grignard Reagent from 2-Bromomethyl-1,3-dioxolane, a Novel and Efficient d2-

Reagent: Synthesis of Branched-Chain Carbohydrate Derivatives, Chemtracts, Org. Chem. 1997,

10, 545-549.

D. Hoppe,

Generation and Reactions of Chiral, Mesomerically Stabilized Lithium Carbanions in New

Horizons in Organic Synthesis (Eds.: V. Nair, S. Kumar), New Age International Publishers, New

Delhi 1997, pp. 130-145.

1996

O. Prien, D. Hoppe,

Simple Synthesis of Enantiomerically Pure, Protected cis-Bicyclo[4.4.0]decane-1-carboxaldehyde

Derivatives from Cyclohexanones by the 3-Arenesulfonyloxazolidine Route,


H. Paulsen, C. Graeve, D. Hoppe,

Convenient Synthesis of Enantiomerically Enriched (Oxybutenyl)stannanes and Their Lewis Acid

Catalyzed Homoaldol Reactions,

Synthesis 1996, 141-144.

H. Paulsen, C. Graeve, R. Fröhlich, D. Hoppe,

Enantioselective Synthesis of Bicyclic Tetrahydrofuran Carboxaldehydes from Chiral 3-Stannylbut-

1-enyl Carbamates by Tandem Homoaldol/Aldol Reaction,

Synthesis 1996, 145-148.

C. Derwing, D. Hoppe,

Synthesis of Enantioenriched Tertiary Benzylic Alcohols via Stereospecific Lithiation of Secondary

Benzyl Carbamates - Design of Dialkylcarbamates, Cleavable under Basic, Mild Conditions,

Synthesis 1996, 149-154.

J. Haller, T. Hense, D. Hoppe,

Experimental and Theoretical Studies of the Internal Stereodifferentiation Occuring During the

Lithiation of β-Stereogenic Alkyl Carbamates. Kinetic Resolutions by (−)-Sparteine-Mediated

Deprotonation,

Liebigs Ann. 1996, 489-500.

D. Hoppe, H. Ahrens, W. Guarnieri, H. Helmke, S. Kolczewski,

Heteroatom-Directed Lithiations of Chiral Alkyl Carbamates: a Powerful Tool for Enantioselective

Synthesis,

Pure Appl. Chem. 1996, 68, 613-618.

I. Hoppe, D. Hoppe, M. Marsch, K. Harms, G. Boche,

Crystal structure of (1R)-1-methyl-1-(α-methylbenzyl-carboxamido)-indene, C19H19NO,

Z. Kristallographie 1996, 211, 331-332.

T. Bach, D. Hoppe,

Differentiation of Enantiotopic Double Bonds by a Chiral Diene,

Chemtracts, Org. Chem. 1996, 9, 93-97.

1995

B. Kaiser, D. Hoppe,

Preparation and Detection of Enantiomerically Enriched and Configurationally Stable α-

Thioalkyllithium Compounds,


H. Helmke, D. Hoppe,

Chelation-Directed Asymmetric Lithiation and C-Substitution of 1,2,4-Butanetriol Acetonide,

Synlett 1995, 978-980.

I. Hoppe, M. Marsch, K. Harms, G. Boche, D. Hoppe,

Generation of Enantiomerically Enriched Lithium Indenides by Means of (−)-Sparteine: Structure,

Stereoselective Substitution, and Solvent Effects,

Angew. Chem. 1995, 107, 2328-2330, Angew. Chem. Int. Engl. 1995, 34, 2158-2160.

D. Hoppe,

Formation of C-C Bonds by Addition of Benzyl-Type Organometallic Compounds to Carbonyl

Groups,

in Houben-Weyl, Stereoselective Synthesis (Eds.: G. Helmchen, R. W. Hoffmann, J. Mulzer, E.

Schaumann), Bd. E 21b, Thieme-Verlag, Stuttgart 1995, 1335-1355.

D. Hoppe,

Formation of C-C Bonds by Addition of Allyl-Type Organometallic Compounds to Carbonyl

Compounds. General Aspects,



D. Hoppe,


Compounds. Allyl Alkali Metal Reagents (M = Li, Na, K),



D. Hoppe,


Compounds. Allylmagnesium Reagents,



D. Hoppe,


Compounds. Allylzinc and Allylcadmium Reagents,



D. Hoppe,


Compounds, Allyltitanium and Allylzirconium Reagents,



D. Hoppe,


Compounds. Allylchromium Reagents,



D. Hoppe,


Compounds. Allylmolybdenum Reagents,



D. Hoppe,

1-(Benzyloxymethoxy)propyllithium,

in Encyclopedia of Reagents for Organic Synthesis (Ed.: L. A. Paquette), Bd. 1, Wiley, Chichester

1995, 362-365.

D. Hoppe,

(E)-1-(N,N-Diisopropylcarbamoyloxy)lithium,

in Encyclopedia of Reagents for Organic Synthesis (Ed.: L. A. Paquette), Bd. 2, Wiley, Chichester

1995, 1927-1929.

D. Hoppe,

(−)-Sparteine,

in Encyclopedia of Reagents for Organic Synthesis (Eds.: L. A. Paquette), Bd. 7, Wiley, Chichester

1995, 4662-4664.

1994

D. Hoppe, F. Hintze, P. Tebben, M. Paetow, H. Ahrens, J. Schwerdtfeger, P. Sommerfeld, J. Haller,

W. Guarnieri, S. Kolczewski, T. Hense, I. Hoppe,

Enantioselective Synthesis via Sparteine-Induced Asymmetric Deprotonation,

Pure Appl. Chem. 1994, 66, 1479-1486.

A. Carstens, D. Hoppe,

Generation of a Configurationally Stable, Enantioenriched α-Oxy-α-methyl-benzyllithium:

Stereodivergence of Its Electrophilic Substitution,

Tetrahedron 1994, 50, 6097-6108.

T. Harder, T. Löhl, M. Bolte, K. Wagner, D. Hoppe,

Enantioselective Synthesis of α-Branched α-Hydroxy Ketones via Chiral N-Sulfonyl-2-alkyl-2-

cyano-1,3-oxazolidines,


W. Guarnieri, M. Grehl, D. Hoppe,

Regio- and Stereoselective Electrophilic C-Substituion of 2-(N,N-Dibenzylamino)-1,ϖ-alkanediols

by Lithiation of the Their Carbamates,

Angew. Chem. Int. Ed. Engl. 1994, 33, 1734-1737; Angew. Chem. 1994, 106, 1815-1818.

M. Paetow, M. Kotthaus, M. Grehl, R. Fröhlich, D. Hoppe,

Enantioselective Cyclopropane Synthesis. Stereodivergent Courses of the 1,3-Elimination Reaction,

Dependent on the Lewis Acid,

Synlett 1994, 12, 1034-1036.

O. Prien, H. Hoffmann, K. Conde-Frieboes, T. Krettek, B. Berger, K. Wagner, M. Bolte, D. Hoppe,

Synthesis of Highyl Functionalized, Enantiomerically and Diastereomerically Pure Cyclohexane

Derivates via Michael Addition of Chiral 3-Tosyl-2-(2-oxo-alkyl)-1,3-oxazolidines and Methyl

Vinyl Ketone,

Synthesis 1994, 1313-1321.

1993

D. Hoppe, M. Paetow, F. Hintze,

Stereodivergent Enantioselective Synthesis by Exploiting Unusually Large Kinetic H/D Isotope

Effects on Deprotonation,


J. Haller, T. Hense, D. Hoppe,

Kinetic Resolution of β-Stereogenic O-Alkyl Carbamates by (−)-Sparteine-Assisted Deprotonation.

External versus Internal Chiral Induction,

Synlett 1993, 726-728.

H. Hoffmann, M. Bolte, B. Berger, D. Hoppe,

Asymmetric Synthesis of cis-Hydrindanediones by Diels-Alder Reaction of Cyclopentenones

Bearing a 3-Sulfonyl-1,3-Oxazolidine Ring as Chiral Auxiliary,


K. Conde-Frieboes, T. Harder, D. Aulbert, C. Strahringer, M. Bolte, D. Hoppe,

Convenient Preparation of Stereochemically Homogeneous 2-Acyl-3-sulfonyl-1,3-oxazolidines and

Diastereoselective Grignard Additons to Form Protected Enantiopure 2-Hydroxyalkanals,

Synlett 1993, 921-923.

1992

B. Peschke, J. Lüßmann, M. Dyrbusch, D. Hoppe,

Diastereo- and Enantioselective Synthesis of 1,2:5,6-Diepoxy-4-hydroxyalkyl Carbamates.

Regioselective Ring Opening and Their Transformation into Doubly C-Branched Deoxy Sugar

Analogues,

Chem. Ber. 1992, 125, 1421-1430.

F. Rehders, D. Hoppe,

Synthesis of Dihydroxyethylene Isosteres of Dipeptides. 1. Enantiomerically and

Diastereomerically Pure 2-Alkyl-5-amino-3-(dimethylphenylsilyl)-4-octanolides from (S)-N,N-

Dibenzylleucinal,

Synthesis 1992, 859-864.

F. Rehders, D. Hoppe,

Synthesis of Dihydroxyethylene Isosteres of Dipeptides; 2. Isosteres of Leu-Ala and Leu-Val from

Suitably Substituted 3-Dimethylphenylsilyl-4-octanolides,

Synthesis 1992, 865-870.

O. Zschage, D. Hoppe,

Sparteine Complexes of Lithiated Primary O-2-Alkenyl Carbamates. Stereochemistry of the

Lithium-Titanium Exchange and Application for the Synthesis of Enantiomerically Enriched γ-

Lactones,

Tetrahedron 1992, 48, 5657-5666.

H. Paulsen, D. Hoppe,

Synthesis of the Insect Pheromone (+)-Eldanolide by Enantioselective Homoaldol Reaction,

Tetrahedron 1992, 48, 5667-5670.

O. Zschage, J.-R. Schwark, T. Krämer, D. Hoppe,

Enantiomerically Enriched 1-(N,N-Diisopropylcarbamoyloxy)-1,3-dimethyl-allyllithium:

Stereochemistry of the Stannylation, Titanation, and the Homoaldol Reaction,

Tetrahedron 1992, 48, 8377-8388.

O. Zschage, D. Hoppe,

1-(N,N-Diisopropropylcarbamoyloxy)-1,3-dimethylallyllithium/(−)-Sparteine: Stereochemistry of

the Enantioselective Carboxylation and Methoxycarbonylation,

Tetrahedron 1992, 48, 8389-8392.

K. Conde-Frieboes, D. Hoppe,

Norpseudoephedrine-Derived 2-Methoxy-3-sulfonyl-1,3-oxazolidines: Chiral, Highly

Diastereoselective Formyl Cation Equivalents,

Tetrahedron 1992, 48, 6011-6020.

M. Paetow, H. Ahrens, D. Hoppe,

Chiral α,ω Dioxy-Carbanions from 1,3-Propanediol and 1,4-Butanediol by Sparteine-Assisted

Deprotonation. Enantioselective Synthesis of 1,3- and 1,4-Diols, (R)-Pantolactone, and a

Cyclopropane,


H. Ahrens, M. Paetow, D. Hoppe,

Stereoselective Generation of 1,3- and 1,4-Dioxy-Substituted Carbanions by Sparteine-Assisted

Deprotonation of Chiral Precursors: Substrate or Reagent Control in the Synthesis of α,γ- and α,δ-

Diols, Tetrahedron Lett. 1992, 33, 5327-5330.

P. Sommerfeld, D. Hoppe,

Enantioselective Generation of 3-Amino-1-oxy-substituted Carbanions by Sparteine-Induced

Deprotonation. Asymmetric Synthesis of 3-Hydroxy-alkylamines,

Synlett 1992, 764-766.

F. Hintze, D. Hoppe,

Enantioselective Synthesis of (S)-2-Tridecyl Acetate, a Pheromone of Drosophila mulleri, via (−)-

Sparteine-Assisted Deprotonation of 1-Dodecanol,

Synthesis 1992, 1216-1218.

J. Schwerdtfeger, D. Hoppe,

Stereoselective Generation of 1-Acyloxy-2-amino Carbanions by Deprotonation. Synthesis of

Enantiomerically and Diastereomerically Pure β-Amino Alcohols,


G. Boche, F. Haller, K. Harms, D. Hoppe, W. Koch, J. Lorenz, M. Marsch, A. Opel, L. Tümmler,

O. Zschage,

Crystal Structure and Reactivity of Oxygen (Aryloxy; Carbamoyloxy; Silyloxy)-Substituted

Lithium Compounds,

in New Aspects of Organic Chemistry II, S. 159 - 179, Kodansha 1992.

1991

S. Dreller, M. Dyrbusch, D. Hoppe,

Synthesis of Enantiomerically Enriched Allenes via Chiral, Configurationally Stable 1-Lithio-2-

alkynyl Carbamates,

Synlett 1991, 397-400.

U. Behrens, C. Wolff, D. Hoppe,

Stereoselective Synthesis of Alkyl α-(1,3-Alkadien-2-yl)acetates and -propionates by Allene

Claisen Rearrangement,

Synthesis 1991, 644-646.

M. Marsch, K. Harms, O. Zschage, D. Hoppe, G. Boche,

h-1-(1S, 2E)-1-(N,N-diisopropylcarbamoyloxy)- 3-trimethylsilylallyllithium(bond)-Sparteine:

Structure of a Chiral, Carbamoyloxy-substituted Allyllithium Compound,


R. Hanko, K. Rabe, R. Dally, D. Hoppe,

Stereoselective Synthesis of Cyclic Dipeptide Hydroxyalkyl Isosteres via Metalated N,N-

Dialkylcarbamate 2-Alkenyl Esters,


I. Hoppe, H. Hoffmann, I. Gärtner, T. Krettek, D. Hoppe,

Diastereoselective Synthesis of Enantiomerically Pure 3-Organosulfonyl-2-(2-oxocycloalkyl)-1,3-

oxazolidines from 2-Formylcycloalkanones and β-Aminoalkanols,

Synthesis 1991, 1157-1162.

1990

O. Zschage, J.-R. Schwark, D. Hoppe,

Preparation of an Enantiomerically Enriched Allyllithium Derivative by Deprotonation with Kinetic

Resolution of Enantiomers,


K. Conde-Frieboes, D. Hoppe,

Synthesis of Enantiomerically Pure 2,4-trans-Substituted 3-Arenesulfonyl-1,3-oxazolidines by

Lewis Acid Mediated Substitution of the 2-Methoxy-Derivatives and their Epimerization,

Synlett 1990, 99-102.

J.-R. Schwark, D. Hoppe,

Synthesis of Enantiomerically Pure 1-Methyl-2-alkenyl N,N-Diisopropyl-carbamates from (S)- or

(R)-Lactates,

Synthesis 1990, 291-294.

D. Hoppe, A. Carstens, T. Krämer,

Generation of a Configurationally Stable Chiral Benzyllithium Derivative, and the Capricious

Stereochemistry of Its Electrophilic Substitution,


D. Hoppe, F. Hintze, P. Tebben,

Chiral Lithium-1-oxyalkanides by Asymmetric Deprotonation; Enantioselective Synthesis of 2-

Hydroxyalkanoic Acids and Secondary Alcohols,


D. Hoppe, T. Krämer, J.-R. Schwark, O. Zschage,

Metallated 2-alkenyl carbamates: chiral homoenolate reagents for asymmetric synthesis,

Pure Appl. Chem. 1990, 62, 1999-2006.

D. Hoppe, O. Zschage,

Chiral Metallated Carbamates: Tools for New Strategies in Asymmetric Synthesis,

Hrsg. K. H. Dötz; R. W. Hoffmann, in Organic Synthesis via Organometallics, pp. 267-283,

Vieweg-Verlag 1990.

I. Hoppe, D. Hoppe, R. Herbst-Irmer, E. Egert,

Asymmetric Aldol Addition Reactions of a Chiral 3-Sulfonyl-1,3-oxazolidine-Masked Lithium 2-

Formylcyclohexanone Enolate,


1989

I. Hoppe, D. Hoppe, C. Wolff, E. Egert, R. Herbst,

3-Arylsulfonyloxazolidines as Chiral Templates; Asymmetric Synthesis of 2-Substituted 2-

Hydroxycyclohexanecarbaldehydes from 2-Hydroxymethylenecyclohexanone,


D. Hoppe, O. Zschage,

Asymmetric Homoaldol Reaction by Enantioselective Lithiation of a Prochiral 2-Butenyl

Carbamate;


D. Hoppe, G. Tarara, M. Wilckens,

Enantiomerically Pure 1-(Carbamoyloxy)oxiranes and its Utility in the Synthesis of D- and L-3,6-

Dideoxy-3-C-methyl-hexofuranosides via the Homoaldol Reaction,


G. Tarara, D. Hoppe,

Total Synthesis of Protected D-altro- and D-galacto-3,6-Dideoxy-3-C-methyl-aldohexoses; Key

Intermediates of a Rifamycin S Synthesis,


D. Hoppe,

Asymmetric Allylation of Aldehydes Mediated by D-Glucose-Derived Titanium Reagents,

Chemtracts: Organic Chemistry 1989, 2, 353-357.

D. Hoppe, H. Schmincke, H.-W. Kleemann,

Studies Toward the Total Synthesis of 1-Oxacephalosporins 1: 3-Amino-4-thio-2-azetidinones with

Protected γ,γ'-Dihydroxyalkenoate Side Chain,

Tetrahedron 1989, 45, 687-694.

D. Hoppe, H. Schmincke, H.-W. Kleemann,

Studies Toward the Total Synthesis of 1-Oxacephalosporins 2: Synthesis and Reactions of

Oxazolinoazetidinones Bearing a γ,γ'-Bisoxygen-functionalized β-Methylbutenoate Side Chain,

Tetrahedron 1989, 45, 695-699.

H. Schmincke, D. Hoppe,

Studies Toward the Total Synthesis of 1-Oxacephalosporins 3: Synthesis of a (±)-trans-7-

Benzoylamino-3-carbamoyloxymethyl-1-oxa-3-cephem-3-carboxylate from 1,3-Dihydroxyacetone,

Tetrahedron 1989, 45, 701-707.

M. Reggelin, P. Tebben, D. Hoppe,

Synthesis and Deprotonation of 1-(p-Toluenesulfonyl)-2-alkenyl Carbamates. Dichotomous Achiral

d1 and Chiral d

3 Reagents for Carbonyl Additions Directed by Metal Exchange,


P. Tebben, M. Reggelin, D. Hoppe,

Enantiomerically Pure α',β'-Difunctionalized Enones by Highly Diastereoselective Nucleophilic

Alkenoylation of Chiral Aldehydes,


D. Hoppe, T. Krämer, C. Freire Erdbrügger, E. Egert,

Synthesis of Highly Substituted, Diastereomerically and Enantiomerically Pure 3-Acyl-

tetrahydrofurans from 4-Hydroxy-1-alkenylcarbamates,


T. Krämer, J.-R. Schwark, D. Hoppe,

Enantiomerically Enriched Allylstannanes from Chiral Allyllithium Derivatives and their Highly

Regio-, Diastereo- and Enantioselective Hydroxyalkylation,


1987

D. Hoppe, C. Gonschorrek,

4-Oxy-Substituted 1-Lithio-1,2-alkadienyl Carbamates: Trapping of Configuratively Stable Allenic

Carbanions and Stereospecific 1,4-Elimination for the Synthesis of Alk-3-en-1-ynyl Carbamates,


E. Egert, H. Beck, D. Schmidt, C. Gonschorrek, D. Hoppe,

Stereoselective Synthesis of Functionalized, Tetra- and Penta-substituted 1,3-Butadienes by Allene

Claisen Rearrangement,


D. Hoppe, C. Gonschorrek, D. Schmidt, E. Egert,

Highly Regio- and syn-Diastereoselective Synthesis of 4-Hydroxy-1,2-alkadienylcarbamates from

α-Titanated 2-Alkynylcarbamates and Aldehydes,

Tetrahedron 1987, 43, 2457-2466.

D. Hoppe, T. Hilpert,

Enantioselective Total Synthesis of the Fungicide β-Lactam Antibiotic (−)-(2S,5S)-2-(2-

Hydroxyethyl)clavam and its (+)-(2S,5R)-Epimer,

Tetrahedron 1987, 43, 2467-2474.

D. Hoppe, G. Tarara, M. Wilckens, P. G. Jones, Schmidt, J. J. Stezowski,

Enantioselective Synthesis of Methylfuranosides of Unnatural 3,6-Dideoxy-3-methylaldohexoses

from Lactates by Homoaldol Reactions,

Angew. Chem. Int. Ed. Eng. 1987, 26, 1034-1035; Angew. Chem. 1987, 99, 1079-1080.

R. W. Hoffmann, J. Lanz, R. Metternich, G. Tarara, D. Hoppe,

Estimation of the Configurational Stability of Chiral Organometallic Reagents,


T. Krämer, D. Hoppe,

Reagent-Controlled Enantioselective Homoaldol Reaction by means of Chiral (α-Oxyallyl)lithiums

Enantio-Divergent Tuning by Achiral Titanium Reagents,


1986

D. Hoppe,

Synthesis of Enantiomerically Pure Unnatural Compounds via Non-Biomimetic Homoaldol

Reactions

in: M. P. Schneider (Ed.) Enzymes as Catalysts in Organic Synthesis, 177-198, NATO ASI Series

Vol. C 178; Reidel, Dordrecht 1986.

D. Hoppe, J. Lüßmann, P. G. Jones, D. Schmidt, G. M. Sheldrick,

Highly Diastereoselective Synthesis of 1,2-Epoxy-4-hydroxyalkyl Carbamates. Masked and

Activated α, γ-Dihydroxy-alkanals and –alkanones,


J. Lüßmann, D. Hoppe, P. G. Jones, C. Fittschen, G. M. Sheldrick.

Diastereoselective Synthesis of 2,3,4-Trisubstituted γ-Lactols and γ-Lactones via Regio- and

Stereocontrolled Opening of a 1,2-Epoxy-4-Hydroxyalkyl Carbamate with Hetero-Nucleophiles,


D. Hoppe, T. Krämer,

α-Deprotonation of an α-Chiral 2-Alkenylcarbamate with Retention and Lithium-Titanium

Exchange with Inversion - the Homoaldol Reaction with 1,3-Chirality Transfer,


1985

E. van Hülsen, D. Hoppe,

Completely Stereoselective Synthesis of all four Stereoisomeric 1-Carbamoyloxy-1,3-alkadienes

via anti-Diastereoselective Homoaldol Reaction from Aldehydes and a Single Carbon-Three-Unit,


D. Hoppe, C. Gonschorrek, E. Egert, D. Schmidt,

Allene Claisen Rearrangement with 1,4-Chirality Transfer,


D. Hoppe, R. Hanko, A. Brönneke, F. Lichtenberg, E. van Hülsen,

Lithiierung acyclischer N,N-Dialkylcarbamidsäure-2-alkenylester; Silylierung und γ-selektive α-

Hydroxyalkylierung von Homoenolat-Reagenzien,

Chem. Ber. 1985, 118, 2822-2851.

1984

D. Hoppe, F. Lichtenberg,

syn-Diastereoselective Homoaldol Reactions: γ-Hydroxyalkylation of (Z)-2-Butenyl Carbamates

and Synthesis of β,γ-cis-Di- and -Trisubstituted γ-Lactones,


D. Hoppe,

Review: Homoaldol Reaction or How One Can Have a Grasp of the Problems of Regio- and

Stereochemistry,

Angew. Chem. Int. Ed. Engl. 1984, 23, 932-948, Angew. Chem. 1984, 96, 930-946.

1983

D. Hoppe, C. Riemenschneider,

Regio- and Diastereoselective Synthesis of (4-Hydroxy-3-methyl-1,2-alkadienyl)carbamates from

α-Titanated 2-Butynylcarbamates and Aldehydes,


D. Hoppe, A. Brönneke,

Highly Diastereoselective Synthesis of Di- and Trisubstituted 4-Butanolides from Aldehydes and

Ketones via Three-Carbon-Extension by Allylic Homoenolate Reagents,


D. Hoppe, G. M. Sheldrick, E. Egert, P. Kaars,

Synthesis and Structure of (Z)-3-Amino-4-oxo-2-azetidinesulfonic Acids, Angew. Chem. Int. Ed.

Engl. 1983, 22, 886-887;

Angew. Chem. 1983, 95, 912-913; Angew. Chem. Suppl. 1983, 1333-1342.

1982

D. Hoppe, F. Lichtenberg,

Diastereoselective Homoaldol Reaction with a (1-Oxycrotyl)aluminum Compound, a Homoenolate

Equivalent of n-Butanal,

Angew. Chem. Int. Ed. Engl. 1982, 21, 372; Angew. Chem. 1982, 94, 378; Angew. Chem. Suppl.

1982, 961-972.

R. Hanko, D. Hoppe,

Highly Diastereo- and Regioselective Homoaldol Reactions with (1-Oxyallyl)titanium Derivatives,


D. Hoppe, A. Brönneke,

Synthesis of N,N-Dialkylcarbamic Acid (1-Arylalk-1-yl)esters by Lithiation and Substitution of

Benzylic Type Carbamates,

Synthesis 1982, 1045-1048.

D. Hoppe,

Focus on Synthesis. Enantioselective Synthesis of β-Lactam Antibiotics,

Nachr. Chem. Techn. Lab. 1982, 30, 24-27.

D. Hoppe,

Woodward’s Synthesis of Erythromycin,


D. Hoppe,

Alkylation of Vinylogeous Ester, Carboxylate, and Amide Enolates,


D. Hoppe,

Transition Metal-Catalyzed Stereocontrolled Epoxydations,


D. Hoppe,

Carbonyl Compounds as Dienophils in the Diels-Alder Reaction,


D. Hoppe,

Total Synthesis of Calcimycin,

Nachr. Chem. Techn. Lab. 1982, 30, 581-582

D. Hoppe,

Synthesis of Pure Enantioners of α-Amino Acids I,


D. Hoppe,

Synthesis of Pure Enantioners of α-Amino Acids II,


D. Hoppe,

New Total Synthesis of Monosaccharides,


D. Hoppe,

Diastereoselective Carbon-Carbon Bonds and Their Stereochemical Specification,


1981

R. Hanko, D. Hoppe,

Dilithiated Allyl N-Alkyl- or N-Phenylcarbamates, Readily Accessible Propionaldehyde-d3

Equivalents,


D. Hoppe, R. Hanko, A. Brönneke, F. Lichtenberg,

Highly Alkylated 1-Oxyallyl Anions from N,N-Dialkylcarbamic Acid Allyl Esters: γ-

Hydroxyalkylation (Homoaldol Reaction), Angew. Chem. Int. Ed. Engl. 1981, 20, 1024-1026; Angew. Chem. 1981, 93, 1106-1108.

1980

D. Hoppe, L. Beckmann, R. Follmann,

α-Carbamoyloxymethyl-Substituted Lithium Enethiolates from 1-(N,N-Dimethylcarbamoylthio)-2-

methyl-1-propenyllithium,


D. Hoppe, M. Kloft,

Allgemeine Synthese von N-geschützten 2-(trans-4-Alkylthio-3-amino-2-oxoazetidinyl)acrylsäure-

alkylestern (trans-7-Amino-1,2-secoceph-3-em-4-carbonsäureestern) mit modifizierter Seitenkette,

Liebigs Ann. Chem. 1980, 1512-1526.

D. Hoppe, M. Kloft,

Exchange of Tritylthio anf Methylthio Groups in N-Protected Alkyl 2-(trans-4-Alkylthio-3-amino-

2-oxo-azetidin-1-yl)acrylates,


D. Hoppe, R. Hanko, A. Brönneke,

Lithiated Allyl N,N-Dialkylcarbamates as Homoenolate Equivalents; Synthesis of Protected 4-

Oxoalkanoates,


D. Hoppe, L. Beckmann,

2-Azaallyl Anions from Dialkyl N-Benzyliminodithiocarbonates, monothiocarbonates, and -

carbonates as Benzylamine Anion Equivalents,


D. Hoppe, R. Follmann, L. Beckmann,

Synthesis of 2-Alkylimino- and 2-Arylimino-1,3-oxathiolanes from lithiated S,S-Dialkyl

Imidodithiocarbanates and Carbonyl Compounds,


D. Hoppe, R. Follmann,

Conversion of 2-Methylimino-1,3-oxathiolanes into Thiiranes,

Liebigs Ann. 1980, 1779-1785.

1979-1975

D. Hoppe, L. Beckmann,

Deprotonierung und selektive Mono- und Dialkylierung von N-Bis(alkylthio)methylen-glycinestern

zum Aufbau von kettenverlängerten und α-verzweigten α-Aminosäureestern,


D. Hoppe, E. Raude,

Zur Synthese von 3-N-[Bis(alkylthio)methylen]amino-2-azetidinonen durch Imin-Säurechlorid-

Reaktion,


M. Kloft, D. Hoppe,

Notiz zur γ-Bromierung von 2-Isothiocyanato-2-butensäureestern und zur nachfolgenden

nucleophilen Substitution,

Chem. Ber. 1979, 112, 3939-3941.

M. Kloft, D. Hoppe,

(±)-trans-7-Azido-1,2-secoceph-3-em-4-carbonsäureester mit modifizierten Seitenketten aus 5-

substituierten 2-Thiazolin-4-carbonsäureestern,

Tetrahedron Lett. 1977, 2141-2144.

D. Hoppe, M. Kloft,

(±)-trans-7-Azido- und 7-Phthalimido-1,2-seco-ceph-3-em-4-carbonsäureester aus 3-substituierten

2-Isothiocyanato-acrylsäureestern,


D. Hoppe,

Metallierte Stickstoff-Derivate der Kohlensäure in der organischen Synthese - Bausteine für das

Penicillin- und Cephalosporin-Gerüst,

Habilitationsschrift, Universität Göttingen, 1977.


Homologization of Aldehydes and Ketones to Thiiranes or S-Vinyl Thiocarbamates via 2-

Alkylimino-1,3-oxa-thiolanes,


E. Raude, D. Hoppe,

A New cis-Stereospecific β-Lactam Ring Closure,


I. Hoppe, D. Hoppe, U. Schöllkopf,

α-Metallierte α-Isothiocyanatoalkansäureester - ein neuer Typ von 2-Azaallylanionen,



2-Thioxo-1,3-oxazoline durch Cycloaddition von α-metallierten Alkylisothiocyanaten an

Carbonylverbindungen,

Chem. Ber. 1976, 109, 3047-3061.


α-(Alkoxycarbonylamino)acrylsäuresester (N-Acyl-α,β-dehydroaminosäureester) durch

baseninduzierte Ringöffnung von 3-Alkoxycarbonyl-2-thioxo-4-oxazolidincarbonsäureestern,

Chem. Ber. 1976, 109, 3062-3078.

D. Hoppe,

2-Alkylthio-2-oxazolin-4-carbonsäureester und ihre baseninduzierte Ringöffnung zu 2-(N-

[(Alkylthio)carbonyl]amino)acrylsäureestern,


D. Hoppe, M. Kloft,

Zur Synthese von 2-Isothiocyanatoacrylsäureestern aus Isothiocyanatoessigsäureestern und

Carbonylverbindungen,


M. Kloft, D. Hoppe,

Ringschlüsse bei der Addition von Nucleophilen an α-Isothiocyanatoacrylsäureester,


D. Hoppe,

Reaktionen von 2-Isothiocyanato-3,3-dimethylacrylsäure-äthylester mit 5-Oxazolon-Anionen,


U. Schöllkopf, D. Hoppe, R. Jentsch,

Höhere Aminosäuren durch Alkylieren von α-metallierten α-Isocyanpropionsäure- und –

essigsäureestern,

Chem. Ber. 1975, 108, 1580-1592.

D. Hoppe,

Metalated Dialkyl N-Alkyliminocarbonates: New Masked α-Amino and α-Thio Carbanions,


D. Hoppe,

Chain-Extended and α-Branched α-Amino Acids by Alkylation of Metalated α-

[Bis(alkylthio)methyleneamino] Acid Esters,


1974-1969

D. Hoppe,

Review: α-Metalated Isocyanides in Organic Synthesis. New Synthetic Methods,

Angew. Chem. Int. Ed. Engl. 1974, 13, 789-804; Angew. Chem. 1974, 86, 878-893

sowie New Synthetic Methods, Vol. 2 (Verlag Chemie, Weinheim 1975)

U. Schöllkopf, D. Hoppe,

5-Substituted Ethyl 2-Thiazoline-4-carboxylates,


U. Schöllkopf, R. Harms, D. Hoppe,

1-Amino-1-cyclopropancarbonsäureester über 1-Isocyan-cyclopropancarbonsäure-äthylester,


D. Hoppe,

Ethyl 3-Acyl-2-thioxo-1,3-oxazolidine-4-carboxylates and Their Conversion into Ethyl α-(N-

Acylamino)acrylates,


D. Hoppe,

2-Alkylthio-2-oxazoline-4-carboxylic Esters and Their Conversion into α-(N-

Alkylthiocarbonylamino)acrylic Esters,


D. Hoppe,

3-Substituted 2-Isothiocyanatoacrylic Esters,



Benzyl-N-formyl-cysteine,

Liebigs Ann. Chem.1973, 766, 799-804.

U. Schöllkopf, F. Gerhart, R. Schröder, D. Hoppe,

Synthesen mit α-metallierten Isocyaniden - β-Substituierte α-Formylamino-acrylsäureäthylester aus

α-metallierten Isocyanessigestern und Carbonylverbindungen (Formylaminomethylenierung von

Carbonylverbindungen),

Liebigs Ann. Chem.1972, 766, 116-129.

D. Hoppe, U. Schöllkopf,

Ethyl α-Formylamino-β-hydroxy-acid Esters (β-Substituted N-Formylserine Esters) from Ethyl 2-

Oxazoline-4-carboxylates,


D. Hoppe, U. Schöllkopf,,

Äthoxycarbonyl-2-oxazoline und ihre Hydrolyse zu N-Formyl-β-hydroxy-α-aminosäure-

äthylestern,

Liebigs Ann. Chem. 1972, 763, 1-16.

D. Hoppe,

1,3-Oxazolidine-2-thiones from Alkyl Isothiocyanates and Carbonyl Compounds,


U. Schöllkopf, D. Hoppe, R. Jentsch,

Higher Amino Acids by Alkylation of α-Metalated Isocyanoacetic or -propionic Esters,



β-Substituted N-Formyl-S-benzylcysteines,


D. Hoppe, U. Schöllkopf,

Ethyl 2-Oxazoline-5-carboxylate from Ethyl Isocyanoacetate and Carbonyl Compounds,



N-Formylphenylalanine Ethyl Esters by Hydrogenolysis of Ethyl 5-Aryl-2-oxazoline-4-

carboxylates,

Angew. Chem. Int. Ed. Engl. 1970, 9, 459; Angew. Chem. 1970, 82, 483.

D. Hoppe,

Aminosäure-Synthesen mit α-metallierten α-Isocyancarbonsäureestern,

Dissertation, Universität Göttingen, 1970

U. Schöllkopf, D. Hoppe, N. Rieber, V. Jakobi,

Trimethylsilyl-diazoessigsäureäthylester und seine Photolyse zu Trimethylsilyl-äthoxycarbonyl-

carben,

Liebigs Ann. Chem. 1969, 730, 1-15.

Documents

Publikationsliste Dieter Hoppe 1969-2010 · Synthesis of 2-Alkylidene-cycloalkane-1,3-diols via Enantioselective Intramolecular Carbolithiation, Tetrahedron Lett. 2003, 44, 8979-8982