Helen J. Cooke, Ph.D.

Peer-Reviewed Journal Articles

Cooke, H.J., and A.R. Cooke. 1968. Correlation between the weight of gastric mucosa and mammalian acid secretion. Digestion. Vol. 1: 209-1212.

Cooke, H.J., and J.A. Young. 1970. Development of glomerular filtration rate and electrolyte and osmolal clearance in the late embryonic and newly hatched chicken. Pflugers Arch. Ges. Physiol. Vol. 318: 315-324.

Cooke, H.J., and J.A. Young. 1973. Amino acid transport in the developing chicken. Aust. J. Exp. Biol. Med. Sci. Vol. 51: 199-207.

Cooke, H.J., and D. Dawson. 1978. Transport characteristics of isolated newborn rabbit ileum. Am. J. Physiol. Vol. 234: E257-E261.

Cooke, H.J., C. Arvanitakis, J. Folscroft, and J. Bornstein. 1979. Effect of aspirin on sugar, amino acid, and sodium transport in rat jejunum. Am. J. Physiol. Vol. 2346: E495-E499.

Cooke, H.J., H. Henning Jr., J.D. Wood, and A.R. Cooke. 1980. Jejunal transport properties of the piebald mouse model for Hirschsprung's disease. Am. J. Physiol. Vol. 239: G123-127.

Cooke, H.J., L. Pfankuche, and A.R. Cooke. 1980. Tryptophan transport by isolated newborn rabbit jejunum. Am. J. Physiol. Vol. 239: G306-G310.

Cooke, H.J., and A.R. Cooke. 1982. Effect of tryptophan on the transport properties of newborn rabbit jejunum. Am. J. Physiol. Vol. 242: G308-G312.

Cooke, H.J., R. McCabe, and L.P. Sullivan. 1982. Potassium transport in rabbit descending colon. Am. J. Physiol. Vol. 242: C81-C86.

Cooke, H.J., K. Shonnard, and J.D. Wood. 1983. Effects of neuronal stimulation on mucosal transport in guinea pig ileum. Am. J. Physiol. Vol. 245: G290-G296.

Cooke, H.J., K. Shonnard, G. Highison, and J.D. Wood. 1983. Effects of neurotransmitter release on mucosal transport in guinea pig ileum. Am J. Physiol. Vol. 245: G745-G750.

Cooke, H.J., M. Montakhab, P.R. Wade, and J. D. Wood. 1983. Transmural fluxes of 5-hydroxytrypamine in guinea pig ileum. Am. J. Physiol. Vol. 244: G421-G425.

Cooke, H.J., 1984. Influence of enteric cholinergic neurons on mucosal transport in guinea pig ileum. Am. J. Physiol. Vol. 246: G263-G267.

Cooke, H.J., and H. Carey. 1984. The effects of cisapride on serotonin-evoked mucosal responses in guinea-pig ileum. European J. Pharmacology. Vol. 98: 147-148.

Cooke, H.J., K. Pitman, G. Starr, and J.D. Wood. 1984. Gastric emptying and small intestinal transit in the piebald mouse model for Hirschsprung's disease. Gastroenterology. Vol. 87: 357-361.

Cooke, H.J., P.R. Nemeth, and J.D. Wood. 1984. Histamine action on guinea pig ileal musoca. Am. J. Physiol. Vol. 246: G372-G377.

Cooke, H.J., and H.V. Carey. 1985. Pharmacological analysis of 5-hydroxytryptamine actions on guinea-pig ileal mucosa. European J. Pharmacology. Vol. 111: 329-337.

Carey, H.V. , H.J. Cooke, M. Zafirova. 1985. Mucosal responses evoked by stimulation of ganglion cell somas in the submucosal plexus of the guinea-pig ileum. J. Physiol. Vol. 364: 69-79.

Carey, H.V. , H.J. Cooke, P. Nemeth, and J.D. Wood. 1985. Nerve-mediated action of forskolin on guinea pig ileal mucosa. Experientia. Vol. 41: 1156-1158.

Cooke, H.J., 1986. Neurobiology of the intestinal mucosa. Gastroenterology. Vol. 90: 1057-1081.

Carey, H.V. , and H.J. Cooke. 1986. Submucosal nerves and cholera toxin-induced secretion in guinea pig ileum in vitro. Dig. Diseases and Sciences. Vol. 31: 732-736.

Kuwahara, A., S. Bowen, J. Wang, C. Condon, H.J. Cooke. 1987. Epithelial responses evoked by stimulation of submucosal neurons in guinea pig distal colon. Am. J. Physiol. Vol. 252: G667-G674.

Kuwahara A., X.Y. Tien, L. Wallace, H.J. Cooke. 1987. Cholinergic receptors mediating secretion in guinea pig colon. J. Pharmacol. Expt. Therapeutics. Vol. 242: 600-606.

McCulloch, C.R., A. Kuwahara, C.D. Condon, H.J. Cooke. 1987. Neuropeptide modification of chloride secretion in guinea pig distal colon. Regulatory Peptides. Vol. 19: 35-43.

Cooke, H.J., M. Zafirova, H.V. Carey, J.H. Walsh, and J.Grider. 1987. VIP actions on the guinea pig intestinal mucosa during neural stimulation. Gastroenterology. Vol. 92: 361-370.

Carey, H.V., X.Y. Tien, L. Wallace, H.J. Cooke. 1987. Muscarinic receptor subtypes mediating the mucosal response to neural stimulation of guinea pig ileum. Am. J. Physiol. Vol. 253: G323-G329.

Kuwahara A., HJ Radowicz-Cooke. 1988. Epithelial transport in guinea pig proximal colon: Influence of enteric neurones. J Physiol. Vol. 395: 271-284.

Cooke, H.J., 1988. Complexities of nervous control of the intestinal epithelium. Gastroenterology. Vol. 94: 1087-1096.

Kuwahara, A., H.J. Cooke, H.V. Carey, C. Codon, H. Mekhjian, E.C. Ellison, and B. McGregor. 1989. Stimulation of enteric neurons: Effects on chloride transport in human left colon in vitro. Dig. Dis. Sci. Vol. 34: 206-213.

McCulloch, C.R., H.J. Cooke. 1989. Human alpha-CGRP influences colonic secretion by acting on myenteric neurons. Regulatory Peptides. Vol. 24: 87-96.

Cooke, H.J., 1989. Role of the "little brain" in the gut in water and electrolyte homeostasis. FASEB Journal. Vol. 3: 127-138.

Carey, H.V., H.J. Cooke. 1989. Neuromodulation of intestinal transport in the suckling mouse. Am. J. Physiol. Vol. 256: R481-R486.

Carey, H.V., H.J. Cooke. 1989. Tonic activity of submucosal neurons influences basal ion transport. Life Sciences. Vol. 44: 1083-1088.

Carey, H.V., H.J. Cooke. 1989. TRH evokes chloride secretion via cholinergic pathways in the guinea-pig ileum. E.J. Pharmacol. Vol. 160: 183-186.

Carey, H.V., H.J. Cooke, W.T. Gerthoffer, L.W. Welling. 1989. Intestinal transport in megacolonic mice: Alterations in sugar absorption. Dig. Dis. Sci. Vol. 34: 185-192.

Kuwahara, A., H.J. Cooke. 1990. Tachykinin-induced anion secretion in guinea pig distal colon: Role of neural and inflammatory mediators. J. Pharmacol. Exp. Ther. Vol. 252: 1-7.

Biagi, B., Y.Z. Wang, H.J. Cooke. 1990. Effects of tetrodotoxin on chloride secretion in the rabbit distal colon: Tissue and cellular studies. Am. J. Physiol. Vol. 258: G223-G230.

Wang, Y.Z., H.J. Cooke. 1990. H2 Receptors mediate cyclical chloride secretion in the guinea pig distal colon. Am. J. Physiol. Vol. 258: G887-G893.

Wang, Y.Z., H.J. Cooke, H.C. Su, R. Fertel. 1990. Histamine augments colonic secretion in the guinea pig distal colon. Am. J. Physiol. Vol. 258: G432-G439.

Zafirov, D.H., J.D. Wood, H.J. Cooke. 1991. Thyrotropin-releasing hormone excites submucous neurons in guinea-pig colon. Eur. J. Pharmacol. Vol. 204: 109-112.

Carey, H.V., H.J. Cooke. 1991. Effect of hibernation and jejunal bypass on mucosal structure and function. Am. J. Physiol. Vol. 261: G37-G44.

Frieling,T., H.J. Cooke, J.D. Wood. 1991. Electrophysiological properties of neurons in submucous ganglia of the guinea-pig distal colon. Am J Physiol. Vol. 260: G835-G841.

Frieling,T., H.J. Cooke, J.D. Wood. 1991. Serotonin receptors on submucous neurons in the guinea-pig colon. Am J. Physiol. Vol. 261: G1017-G1023.

Frieling,T., H.J. Cooke, J.D. Wood. 1991. Synaptic transmission in submucous ganglia of the guinea-pig distal colon. Am J. Physiol. Vol. 260: G842-G849.

Wang, Y.Z., J. Palmer, H.J. Cooke. 1991. Neuro-immune regulation of colonic secretion in nematode-infected guinea pigs. Am. J. Physiol. Vol. 260: G307-G314.

Wang, Y.Z., T. Frieling, J.D. Wood, H.J. Cooke. 1991. Neural 5-hydroxytryptamine receptors regulate chloride secretion in the guinea pig distal colon. Am J Physiol. Vol. 261: G833-G840.

Cooke, Helen, J., 1992. Neuromodulation of ion secretion. Current Opinion in Gastroeneterology. Vol. 8: 967-974.

Cooke, Helen, J., H.V. Carey. 1992. Intestinal secretion after jejunal bypass in the ground squirrel. Am J Ph Cooke, Helen, J., ysiol. Vol. 263: R1209-R1214.

Javed, N.H., H.J. Cooke. 1992. Acetylcholine release from colonic submucous neurons associated with Cl- secretion in the guinea pig colon. Am. J. Physiol. Vol. 262: G131-G136.

Javed, N.H., Y.Z. Wang, H.J. Cooke. 1992. Neuro-immune interactions: Role for cholinergic neurons in intestinal anaphylaxis. Am J. Physiol. Vol. 263: G847-G852.

Reddix, R.A., H.J. Cooke. 1992. Neurokinin 1 receptors mediate substance P-induced changes in ion transport in guinea pig ileum. Reg. Peptides. Vol. 39: 215-225.

Frieling,T., J.D. Wood, H.J. Cooke. 1992. Submucosal reflexes: Distension-evoked ion transport in the guinea pig distal colon. Am. J. Physiol. Vol. 263: G91-G96.

Rikihisa, Y., G.H. Johnson, Y.Z. Wang, S. Reed, R. Fertel, H.J. Cooke. 1992. Loss of absorptive capacity for sodium and chloride as a cause of diarrhea in Potomac Horse Fever. Res. Veterinary Sci. Vol. 52: 353-362.

Zafirov, D.H., H.J. Cooke, J.D. Wood. 1993. Elevation of cAMP facilitates noradrenergic transmission in submucous neurons of guinea pig ileum. Am J Physiol. Vol. 264: G442-G446.

Cooke, Helen, J., Y.Z. Wang, R. Rogers. 1993. Coordination of Cl- secretion and contraction by a histamine H2 receptor agonist in guinea pig distal colon. Am J Physiol. Vol. 265: G973-G978.

Frieling,T., H.J. Cooke, J.D. Wood. 1993. Histamine receptors on submucous neurons in the guinea-pig colon. Am. J. Physiol. Vol. 264: G74-G80.

Cooke, Helen, J., 1994. Immune signaling and regulation of intestinal transport. Am J Physiol. Vol. 266: G167-G178.

Cooke, Helen, J., Y.Z. Wang. 1994. H3 receptors: Modulation of histamine-stimulated neural pathways influencing colonic secretion in the guinea pig. J Auton. Nervous System. Vol. 50: 201-207.

Javed, N.H., K.E. Barrett, Y.Z. Wang, J. Bidinger, H.J. Cooke. 1994. Enhanced tissue responsiveness in colonic ion transport of cow's milk-sensitized guinea pigs. Agents and Actions. Vol. 41: 1-7.

Reddix, R.A., A. Kuwahara, L. Wallace, H.J. Cooke. 1994. VIP: A transmitter in submucous neurons mediating colonic secretion in the guinea pig colon. J. Pharmacol. Exp Therap. Vol. 269: 1124-1129.

Frieling,T., H.J. Cooke, J.D. Wood. 1994. Neuroimmune communication in the submucous plexus of guinea-pig colon after sensitization to milk antigen. Am J. Physiol. Vol. 267: G1087-G1093.

Frieling,T., J.M. Palmer, H.J. Cooke, J.D. Wood. 1994. Neuroimmune communication in the submucous plexus of guinea-pig colon after infection with Trichinella spiralis. Gastroenterology. Vol. 107: 1602-1609.

Cooke, Helen, J., Y. Z. Wang, R. Reddix, N.H Javed. 1995. Cholinergic and VIP-ergic pathways mediate histamine H2 receptor-induced cyclical secretion in the guinea pig colon. Am J Physiol. Vol. 268: G465-G470.

Sidhu, M., H.J. Cooke. 1995. Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion. Am J. Physiol. Vol. 269: G346-G351.

Cooke, Helen, J., M Sidhu, Y.Z. Wang. 1997. 5-HT activates neural reflexes regulating secretion in guinea pig colon. Neurogastroenterol. Mot. Vol. 9: 181-186.

Cooke, Helen, J., M. Sidhu, P. Fox, Y.Z. Wang, E. Zimmerman. 1997. Substance P as a mediator of colonic secretory reflexes. Am J Physiol. Vol. 273: G238-G245.

Cooke, Helen, J., M. Sidhu, Y.Z Wang. 1997. Activation of 5-HT1P receptors on submucosal afferents subsequently triggers VIP neurons and chloride secretion in guinea-pig colon. Autonomic Nerv. Sys. Vol. 66: 105-110.

Gantz, I., A Muraoka, Y.K. Yang, L.C. Samuelson, E.M. Zimmerman, H.J. Cooke, T. Yamada. 1997. Cloning and chromosomal localization of a gene (GPR 18) encoding a novel seven transmembrane receptor highly expressed in spleen and testis. Genomics. Vol. 42: 462-466.

Cooke, Helen, J., 1998. Enteric Tears: Chloride secretion and its neural regulation. NIPS. Vol. 13: 275-280.

Cooke, Helen, J., P. Fox, L Alferes, C.C. Fox, and S.A. Wolfe Jr. 1998. Presence of NK1 receptors on a mucosal-like mast cell line, RBL-2H3 cells. Canadian J. Physiol. Pharmacol. Vol. 76: 188-193.

Reddix, R.A., D. Mullet, R. Fertel, H.J. Cooke. 1998. Endogenous nitric oxide inhibits endothelin-1 induced chloride secretion in guinea pig colon. Nitric Oxide: Biology and Chemistry. Vol. 2: 28-36.

Cooke, Helen, J., Y.Z. Wang, C.Y. Liu, H. Zhang, F.L. Christofi. 1999. Activation of neuronal adenosine A1 receptors suppresses secretory reflexes in the guinea pig colon. Am. J. Physiol. Vol. 276: G451-G462.

Christofi, F.L., H. Zhang, J.G. Yu, J. Guzman, J. Xue, M. Kim, Y.Z. Wang, H.J. Cooke. 2001. Differential gene expression of adenosine A1, A2a, A3 receptors in the human enteric nervous system. J Comparative Neurology. Vol. 439: 46-64.

Kim, M., H.J. Cooke, N.H. Javed, H.V. Carey, F. Christofi, H.E. Raybould. 2001. D-Glucose relea Kim, M., ses 5-hydroxytryptamine from human BON cells as a model of enterochromaffin cells. Gastroenterology. Vol. 121: 1400-1406.

Kim, M., N.H. Javed, J.G. Yu, F. Christofi, H.J. Cooke. 2001. Mechanical stimulation activates Gaq signaling pathways and 5-hydroxytryptamine release from human carcinoid BON cells. J. Clin. Invest. Vol. 108: 1051-1059.

Cooke, Helen, J., Wang, Yu-Zhong; Wray, Dawn; O'Dorisio, M Sue; Woltering, Eugene, A; Coy, David, H; Murphy, William, A; Christofi, Fievos, L; Gosh, Pradip; O'Dorisio, Thomas M. 2003. A multi-tyrosinated sst1/2 receptor preferring somatostatin agonist inhibits reflex and immune-mediated secretion in the guinea pig colon. Regulatory peptides. Vol. 114, no. 1: 51-60.

Cooke, Helen, J., Wunderlich, Jacqueline; Christofi, Fievos L. 2003. "The force be with you": ATP in gut mechanosensory transduction. News in Physiological Sciences. Vol. 18: 43-9.

Cooke H.J., Y.Z. Wang, D. Wray, M.S. O'Dorisio, E.A. Woltering, D.H. Coy, W.A. Murphy, F.L. Christofi, P. Gosh, T.M. O'Dorisio. 2003. Corrigendum to "A multi-tyrosinated sst1/2 receptor preferring somatostatin agonist inhibits reflex and immune-mediated secretion in the guinea pig colon. Regulatory Pept. Vol. 115, no. 2: 151.

Sundaram, U., H.H. Hassanin, Z Suntres, J.G. Yu, H.J. Cooke, J. Guzman, F. Christofi. 2003. Rabbit chronic ileitis leads up to up-regulation of adenosine A1/A3 gene products, oxidative stress and immune modulation. Biochemical Pharmacology. Vol. 65: 1529-1538.

Christofi, F.L., L; Kim, Minsoo; Wunderlich, Jacqueline, E; Xue, Jianjing; Suntres, Zach; Cardounel, Arturo; Javed, Najma, H; Yu, Jun Ge; Grants, Iveta; Cooke, Helen J. 2004. Endogenous adenosine differentially modulates 5-hydroxytryptamine release from a human enterochromaffin cell model. Gastroenterology. Vol. 127, no. 1: 188-202.

Cooke, Helen, J; Xue, Jianjing; Yu, Jun Ge; Wunderlich, Jacqueline; Wang, Y-Z; Guzman, Jorge; Javed, Najma; Christofi, Fievos L. 2004. Mechanical stimulation releases nucleotides that activate P2Y1 receptors to trigger neural reflex chloride secretion in guinea pig distal colon. The Journal of Comparative Neurology. Vol. 469, no. 1: 1-15.

Christofi, F.L., J. Wunderlich, J.G. Yu, Y.Z. Wang, J. Xue, J. Gutzman, N. Javed, H.J. Cooke. 2004. Mechanically-evoked reflex electrogenic chloride secretion in rat distal colon is triggered by endogenous nucleotides acting at P2Y1, P2Y2, and P2Y4 receptors. J. Comp Neurology. Vol. 469: 16-36.

Raybould, H, E; Cooke, H, J; Christofi, F L. 2004. Sensory mechanisms: transmitters, modulators and reflexes. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. Vol. 16 Suppl 1: 60-3.

Guzman J, Yu JG, Suntres Z, Bozarov A, Cooke H, Javed N, Auer H, Palatinin J, Hassanain HH, Cardounel AJ, Javed A, Grants I, Wunderlich JE, Christofi, FL. 2006. ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis. Inflammatory Bowel Dis., no. Aug;12(8): 766-89.

Chen Z, Suntres Z, Palmer J, Guzman J, Javed A, Xue J, Cooke HJ, Awad H, Hassanain HH, Cardounal AJ, Christofi FL. 2007. Cyclic AMP signaling contributes to neural plasticity and hyperexcitability in AH sensory neurons following intestinal Trichinella spiralis-induced inflammation. International Journal for Parasitology. Vol. 37, no. 7: 743-761. (IF: 3.337)

Chen Z, Suntres Z, Palmer J, Guzman J, Javed A, Xue J, Yu JG, Cooke HJ, Awad H, Hassanain, HH, Cardounel AJ, FL Christofi. 2007. Cyclic AMP signaling contributes to neural plasticity and hyperexcitablility in AH sensory neurons following intestinal Trichinella spiralis- induced inflammation. International Journal of Parasitology., no. 37: 743-761. Doi:10.101016/j.ijpara.2006.12.018.37:743-761.

Kim M, Christofi F, Xue J, Robinson JM, Cooke HJ. 2007. Mechanically evoked 5-hydroxytryptamine release is mediated by caveolin-associated cholesterol rich membrane domains. Neurogastroenterology and Motility. Vol. 19, no. 4: 309-317. (IF: 3.338)

Kim, M., F. Christofi, J. Xue, J.M. Robinson, and H.J. Cooke. 2007. Mechanically-evoked 5-hydroxytriptamine release is mediated by caveolin-associated cholesterol rich membrane domains. Neurogastroenterology and Motility 19: 309-317.

Wunderlicht, J, BJ Needleman, Z Chen, JG Yu, YZ Wang, I Grants, D MIkami, WS Melvin, HJ Cooke and FL Christofi. 2008. Dual purinergic synaptic transmission in the human enteric nervous system. Am J Physiol, no. 294: G554-G566.

Bozarov A, Wang Yu, Wunderlich J, Hassanain HH, Alhaj M Cooke HJ, Grants I, RenT, Christofi FL. 2009. Activation of low-affinity A3 receptors inhibits the short interplexus neural circuit triggered by histamine. Am J Physiology. no. G1147. Epub 2009.

Fei G, Wang YZ, Liu S, Hu HZ, Wang GD, Qu MH,Wang XY, Xia Y, Sun X, Bohn LM, Cooke HJ, Wood JD. 2009. Stimulation of mucosal secretion by lubiprostone (SP-0211) in guinea pig small intestine and colon. Am J Physiol. Vol. 296, no. 296: Epub 2009 Jan 29.: G823-G832.

Germano, PM, Lieu SN, Xue J, Cooke HJ, Christofi FL, Pisegna JR. 2009. PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells. J Mol Neurosci. Vol. 39, no. Epub2009 Aug 23.: 391-401.

Editor-Reviewed Journal Articles

Cooke, H.J., 1994. The action of opioid agonists on intestinal ion transport. Reg Peptide Newsletter. Vol. 5. (March 21): 68-71.

Books and Monographs

Dr. Helen J Cooke. 1971. Development of renal function in the late-embryonic and hatched chicken. Part I. Development of glomerular filtration, renal clearances and electrolyte transport. Part II. Development of amino acid transport. Ph.D. Thesis ed. University of Sydney.

Chapters in Books

Cooke, H.J., 1983. Tryptophan and intestinal secretion. In Progress in Tryptophan and Serotonin Research. Edited by H.G. Scholossberger, W. Kochen, B. Linzen, H. Steinhart. NY: W. de Gruyter & Co. 563-566.

Cooke, H.J., J.D. Wood. 1985. Murine models for congenital megacolon: Hirschsprung's disease. In Animal Models for Intestinal Disease. Edited by C.J. Pfeiffer. Boca Raton, FL: CRC Press. 181-195.

Cooke, H.J., 1987. Neural and humoral control of small intestinal electrolyte transport. In Physiology of the Gastrointestinal Tract Vol 2. Edited by L.R. Johnson. N.Y.: Raven Press. 1307-1350.

Cooke, H.J., C.R. McCulloch. 1988. Modifications of colonic secretion by neuropeptides in guinea pig distal colon. In Gastrointestinal and Hepatic Secretion: Mechanisms and Control. Edited by J. Davidson, E.A. Shaffer. Calgary: University of Calgary Press. 252-253.

Cooke, H.J., 1989. Neuroeffector relations in the intestinal mucosa in vitro. In Nerves and the Gastrointestinal Tract, 50th Falk Symposium. Edited by M.V. Singer, H. Goebell. Lancaster, England: MTP Press. 265-273.

Cooke, H.J., H.V. Carey. 1990. Neural regulation of intestinal ion transport. In Textbook of Secretory Diarrhea. Edited by E. Lebenthal, M. Duffey. NY: Raven Press. 1-14.

Cooke, H.J., T. Frieling, Y.Z. Wang, J.D. Wood. 1990. Neuroimmuno-modulation of intestinal chloride secretion. In Exocrine Secretion II. Edited by P.Y.D. Wong, J.A. Young. Hong Kong: United League Graphic and Printing Co., Ltd. 39-42.

Cooke, H.J., 1991. Hormones and neurotransmitters regulating intestinal ion transport. In Diarrheal Diseases. Edited by M. Field. NY: Elsevier. 23-48.

Cooke, H.J., 1991. Regulation of colonic transport by the autonomic nervous system. In The Large Intestine: Physiology, Pathophysiology, and Disease. Edited by S.F. Phillips, J.H. Pemberton, R.G. Shorter. NY: Raven Press, Ltd. 169-179.

Cooke, H.J., Calcitonin gene-related peptides: Influence on intestinal ion transport. In Calcitonin Gene-Related Peptide: The First Decade of a Novel Pleiotropic Neuropeptide. Edited by Y. Tache, P. Holzer, M.G. Rosenfeld. NY: NY Academy of Sci. 313-318.

Cooke, H.J., Neuro-modulation of ion secretion by inflammatory mediators. In Neuro-Immuno-Physiology of the Gastrointestinal Tract-Implications for Inflammatory Diseases. Edited by R. Stead, M. Perdue, H.J. Cooke, D. Powell, K. Barrett. NY: NY Acad. Sci. 346-352.

Cooke, H.J., Submucosal neuronal circuitry controlling ion transport and its relation to motility. In Advances in Innervation of the Gastrointestinal Tract. Edited by G. Holle, J.D. Wood. Amsterdam: Elsevier. 433-441.

Cooke, H.J., 1994. Intestinal salt and water transport. In Gut Peptides: Biochemistry and Physiology. Edited by J. Walsh, G.J. Dockray. NY: Raven Press. 749-763.

Cooke, H.J., R.A. Reddix. 1994. Neural regulation of intestinal electrolyte transport. In Physiology of the Gastrointestinal Tract Vol. 3. Edited by L.R Johnson, D. Alpers, J. Christensen, E. Jacobson. NY: Raven Press. 2083-2132.

Cooke, H.J., Y.Z. Wang, R. Rogers. 1994. Neuro-immune interactions: Histamine signals to the intestine. In Innervation of the Gut: Pathophysiological Implications. Edited by Y. Tache, D. Windgate, T. Burks. CRC Press. 307-313.

Cooke, H.J., 1996. Extracellular signaling to the colonic epithelium: Role for enteric nerves. In Studies in Honour of John Atherton Young. Edited by A. Dinudom, P. Komwatana. Sydney: University of Sydney Printing Services. 61-65.

Cooke, H.J., 1997. Peptides, neural circuits, and intestinal secretion. In Textbook of Gastrointestinal Peptide Hormones: Basic and Clinical Aspects. Edited by Y.F. Chen, T. Yamada. Beijing China: Peking Union Medical College and Beijing Medical University Joint Press. 477-482.

Cooke, H.J., 2001. Neurotransmitters in neuronal reflexes regulating intestinal secretion. In Epithelial Transport and Barrier Function: Pathomechanisms in Gastrointestinal Disorders. Edited by J.D. Schulzke, M. Fromm, W.O. Riecken, H.J. Binder. Ann.NY: NY Acad. Sci. 77-80.

Cooke, H.J.,, N. Javed, F. Christofi. 2003. Enteric Neural reflexes and secretions. In Autonomic Neuroimmunology. Edited by E. Goetzl, M. Blennerhassett, J. Biennstock. Berkshire, UK: Harwood Academic Publishers. 35-59.

Cooke, H.J., F. Christofi. 2005. Enteric neural regulation of nucosal secretion. In Physiology of the Gastrointestinal Tract: The Gastrointestinal System. Elsevier.

Guzman J, Yu JG, SUntres Z, Bozarov A, Cooke H, Javed N, Auer H, Palatini J, Hassanain HH, Cardounel AJ, Javed A, Grants I, Wunderlich JE, Christofi, FL. 2006. ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis. In Inflamm Bowel Dis. Aug;12(8):766-89.

Abstracts

Radowicz H.J., and Snedecor J.D. 1965. Alterations in the liver of the hypothyroid chick [Abstract]. Am Zool. Vol. 5: 245.

Cooke, H.J., and Young J.A. 1968. Clearance and microperfusion study of EDTA51 Cr excretion by rat kidney [Abstract]. Aust. J. Exp. Biol. Med. Sci. Vol. 46: 13.

Cooke, H.J., and Young J.A. 1969. Development of renal function in the late embryonic and post-embryonic chicken [Abstract]. Aust. J. Exp. Biol. Med Sci. Vol. 47: 6-7.

Cooke, H.J., and Young, J.A. 1976. Transport characteristics of rabbit ileum [Abstract]. Fed. Proc. Vol. 35: 618.

Cooke, H.J., Arvanitakis C., Folscroft J., and Bornstein J. 1978. Effect of aspirin on jejunal alanine and glucose transport in the rat [Abstract]. Fed. Proc. Vol. 37: 722.

Cooke, H.J., and Wood J.D. 1979. Amino acid absorption in the piebald-lethal mouse jejunum [Abstract]. Gastroenterology. Vol. 76: 1115.

Cooke, H.J., and Wood, J.D. 1979. Transport characteristics of jejunal mucosa in the piebald mouse model for Hirschsprung's disease [Abstract]. The Physiologist. Vol. 22: 22.

Cooke, H.J., Pfankuche L., and Cooke A.R. 1979. Tryptophan and phenylalanine transport by newborn rabbit jejunum [Abstract]. Fed. Proc. Vol. 38: 1238.

Cooke, H.J., 1981. Effects of tryptophan on ion fluxes in newborn rabbit jejunum [Abstract]. Fed Proc. Vol. 40: 362.

Cooke, H.J., McCabe, R., and Sullivan, L.P. 1981. Potassium transport by rabbit descending colon [Abstract]. Fed Proc. Vol. 40: 357.

Cooke, H.J. 1982, Intestinal secretion stimulated by tryptophan in the newborn rabbit [Abstract]. Fed. Proc. Vol. 41: 980.

Cooke, H.J., Pitman, K., Starr, G., and Wood J.D. 1982. Gastric emptying and intestinal transit in the piebald mouse model for Hirschsprung's disease [Abstract]. Gastroenterology. Vol. 82: 1258.

Cooke, H.J., Pittman, K., Starr, G., and Wood, J.D. 1982. Gastrointestinal transit in the piebald mouse model for Hirschsprung's disease [Abstract]. Clin Res. Vol. 30: 37A.

Cooke, H.J., Wade, P.R., and Wood, J.D. 1982. Transmural movement of serotonin in guinea pig ileum [Abstract]. Fed Proc. Vol. 41: 1744.

Cooke, H.J. 1983, Intestinal secretion evoked by neuronal stimulation of guinea pig ileum [Abstract]. Gastroenterology. Vol. 84: 1130.

Cooke, H.J., Nemeth, P., and Wood, J.D. 1983. Nerve-mediated histamine action on guinea pig ileal mucosa [Abstract]. Proc. 29th Congress of International Union Physiol. Sci. Vol. 15: 452.

Cooke, H.J., Shonnard, K., Highison, G., and Wood, J.D. 1983. The Effects of electrical field stimulation and scorpion venom on a chloride-secreting epithelium [Abstract]. Clin. Res. Vol. 31: 35A.

Cooke, H.J., Shonnard, K., Wood, J.D. 1983. Neural control of epithelial transport in guinea pig ileum [Abstract]. Fed Proc. Vol. 42: 1281 [Editor Reviewed]

Cooke, H.J., and Carey, H. 1984. Effects of cisapride, a serotonin antagonist, on neural stimulation of guinea pig ileal mucosa [Abstract]. Fed. Proc. Vol. 43: 1093.

Cooke, H.J., and Carey, H. 1984. Influence of enteric nerves on jejunal mucosal function of the piebald-lethal mouse [Abstract]. Gastroeneterology. Vol. 86: 1040.

Cooke, H.J., and Carey, H. 1984. Jejunal sugar transport and effects of enteric neuronal activity in the piebald mouse model for Hirschsprung's disease [Abstract]. Fed Proc. Vol. 43: 1080.

Cooke, H.J., and Carey, H. 1984. The role of enteric nerves in cholera toxin-induced intestinal secretion in the guinea pig ileum [Abstract]. Gastroenterology. Vol. 86: 1053.

Cooke, H.J., and Carry, H.V. 1984. The intestinal mucosa as a neuro-effector system: cholinergic and serotonergic transmission [Abstract]. Neurosci Abs. Vol. 10: 1097.

Cooke, H.J., Carey, H.V., and Walsh J. 1984. Neural stimulation of intestinal mucosa and the effects of VIP [Abstract]. Gastroenterology. Vol. 86: 1053.

Cooke, H.J., Gerthoffer, W.T., and Franzl, R.E. 1984. Intestinal mucosal ATPase activities of the piebald mouse model for Hirschsprung's disease [Abstract]. Fed. Proc. Vol. 43: 1080.

Cooke, H.J., Carey, H.V., and Gerthoffer, W.T. 1985. Intracellular concentrations and Na-K-ATPase activities of intestinal mucosa of the piebald mouse model for Hirschsprung's disease [Abstract]. Gastroenterology. Vol. 88: 1343.

Cooke, H.J., Carey, H.V., and Zafirova, M. 1985. Ileal secretion evoked by stimulation of ganglion cell somas in the guinea pig submucosal plexus [Abstract]. Fed Proc. Vol. 44: 1743.

Cooke, H.J., Zafirova, M., Carey, H.V., and Walsh, J.H. 1985. Effects of VIP antiserum on neural stimulation of guinea pig intestinal mucosa [Abstract]. Gastroenterology. Vol. 88: 1355.

Cooke, H.J., and Carey, H.V. 1986. Enteric Neural reflex pathways influence basal ion transport in guinea pig ileum [Abstract]. Proceddings of the XXX Congress of International Union of Physiological Sciences. Vol. 16: 105.

Cooke, H.J., and Carey, H.V. 1986. Intestinal transport in hibernating and active ground squirrels [Abstract]. Am. Zoologist. Vol. 26: 52A.

Cooke, H.J., and Carey, H.V. 1986. Submucosal reflex pathways: Regulation of ion transport in guinea pig ileum [Abstract]. Gastroenterology. Vol. 90: 1365.

Cooke, H.J., and Kuwahara, A. 1986. Mediation of neurally-evoked secretion by muscarinic receptors in guinea pig distal colon [Abstract]. Neurosci. Abs. Vol. 12: 816.

Cooke, H.J., and McCulloch, C.R. 1986. Excitatory effect of calcitonin-gene related peptide in colonic secretion in guinea pig distal colon [Abstract]. Neurosci. Abs. Vol. 12: 220.

Cooke, H.J., Bowen, S., Wang, J., and Condon, C. 1986. Distal colonic secretion evoked by stimulation of enteric neurons [Abstract]. Gastroenterology. Vol. 90: 1353.

Cooke, H.J., Carey, H.V. 1986. M2 receptors mediate the cholinergically-evoked Cl- secretory response in guinea pig ileal mucosa [Abstract]. Fed Proc. Vol. 45: 181.

Cooke, H.J., Huwahara, A., Carey, H.V., Condon, C., Mekhjian, H., Ellison, E.C., and McGregor B. 1986. Enteric neural regulation of epithelial ion transport in human left colon [Abstract]. Clin. Res. Vol. 34: 910A.

Cooke, H.J., Kuwahara, A., and Bowen, S. 1986. Activation of enteric colonic nerves: Epithelial responses [Abstract]. Proceedings of the XXX Congress of International Union of Physiological Sciences. Vol. 16: 105.

Cooke, H.J., Kuwahara, A., and Bowen, S. 1986. Neural influences on the proximal colonic mucosa: comparison with distal colon [Abstract]. Gastroenterology. Vol. 90: 150.

Cooke, H.J., and Carey, H.V. 1987. Maintenance of intestinal function in hibernating ground squirrels [Abstract]. Gastroenterology. Vol. 92: 1338.

Cooke, H.J., and Carey, H.V. 1987. Neural control of intestinal ion transport in the ground squirrel, and seasonal hibernator [Abstract]. Zeitschrift fur Gastroeneterologie. Vol. 25: 621.

Cooke, H.J., and Kuwahara, A. 1987. Effect of substance P on ion transport of guinea pig distal colon [Abstract]. Gastroenterology. Vol. 92: 1485.

Cooke, H.J., and McCulloch, C.R. 1987. Effects of adenosine analogues on neurally-evoked chloride secretion in the guinea pig ileum [Abstract]. Gastroenterology. Vol. 92: 1525.

Cooke, H.J., Carey, H.V., and River, J. 1987. Effects of a VIP-antagonist on noncholinergically mediated secretion in guinea pig ileal mucosa [Abstract]. Fed. Proc. Vol. 46: 1077.

Cooke, H.J., Kuwahara, A. 1987. Vasoactive intestinal peptide: A neural mediator of secretion in the guinea pig distal colon [Abstract]. Zeitschrift fur Gastroenterology. Vol. 25: 622.

Cooke, H.J., Kuwahara, A., Ellison, E.C., Mekhjian, H. 1987. Ion transport in the human right colon and influence of enteric nerves [Abstract]. Gastroenterology. Vol. 92: 1485.

Cooke, H.J., Kuwahara, A., Yanaihara, N., and River, J. 1987. Comparison of VIP, PHI, and helodermin on ion transport in guinea pig distal colon [Abstract]. Fed. Proc. Vol. 46: 1077.

Cooke, H.J., McCulloch, C.R., and Condon, C. 1987. Influence of neuropeptides on ion transport in guinea pig distal colon [Abstract]. Fed Proc. Vol. 46: 1078.

Cooke, H.J., and Carey, H.V. 1988. Transport function after intestinal bypass surgery in hibernating and active ground squirrels [Abstract]. Gastroenterology. Vol. 94: A59.

Cooke, H.J., and Wang, Y.Z. 1988. Interaction of a mast cell inflammatory mediator with the enteric nervous system and the epithelium in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 94: A487.

Cooke, H.J., Rikihia, Y., Johnson, G.C., and Reed, S.M. 1988. Pathophysiologic changes of large colon of horses infected with Ehrlichia risticii [Abstract]. Proc 3rd Equine Colic Res. Symp: 58.

Cooke, H.J., Teitelbaum, D.H., Dunaway, D.J., Wise, W.E., Sonino, R.E., Stellin, G., and Harmel Jr., R.P. 1988. Loss of intestinal integrity as a marker of small bowel transplant rejection [Abstract]. Gastroenterology. Vol. 94: A457.

Cooke, H.J., and Biagi, B. 1989. Tetrodotoxin effects in rabbit distal colon [Abstract]. Fed. Proc. Vol. 3: A388.

Cooke, H.J., and Carey, H.V. 1989. Effects of bypass surgery on gut structure and function in hibernating ground squirrels [Abstract]. Fed. Proc. Vol. 3: A1151.

Cooke, H.J., and Javed, N. 1989. Release of acetylcholine from guinea pig distal colonic submucosa/ mucosa [Abstract]. Fed. Proc. Vol. 3: A38.

Cooke, H.J., and Wang, Y.Z. 1989. The inflammatory mediator histamine activates submucosal neurons to drive cyclical chloride secretion in the guinea pig distal colon [Abstract]. Gastroenterology. Vol. 96: A537.

Cooke, H.J., Frieling, T., and Wood, J.D. 1989. Cellular neurophysiology of submucosal ganglion cells in the colon on the guinea pig [Abstract]. Fed Proc. Vol. 3: A388.

Cooke, H.J., Frieling, T., and Wood, J.D. 1989. Intracellular study of actions of the inflammatory mediator histamine on electrical and synaptic behavior of submucosal neurons in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 96: A160.

Cooke, H.J., Tien, X.Y., and Wood, J.D. 1989. Effects of muscarinic receptor antagonist telenzepine on Cl- secretion in guinea pig distal colon [Abstract]. Fed. Proc. Vol. 3: A389.

Cooke, H.J., Tien, X.Y., and Wood, J.D. 1989. Effects of muscarinic receptor antagonist telenzepine on Cl- secretion in guinea pig distal colon [Abstract]. Fed. Proc. Vol. 3: A389.

Cooke, H.J., Wang, Y.Z., and Palmer, M. 1989. Neural, epithelial, and immune interaction in distal colon of guinea pigs infected with Trichinella spiralis [Abstract]. Fed. Proc. Vol. 3: A388.

Cooke, H.J. and Wang, Y.Z. 1990. Histamine acts at H2 receptors on submucosal cholinergic neurons to induce cyclical Cl- secretion in the guinea pig distal colon [Abstract]. Gastroenterology. Vol. 98: A400.

Cooke, H.J. and Wang, Y.Z. 1990. Presynaptic H3 receptors regulate cyclical Cl- secretion in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 98: A400.

Cooke, H.J., Frieling T., and Wood, J.D. 1990. In vitro distension activates submucosal reflex pathways to drive chloride secretion in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 98: A352.

Cooke, H.J., Frieling, T., Kroese, B.A., and Wood, J.D. 1990. Actions of 5-hydroxytryptamine on electrical and synaptic behavior of submucosal neurons in guinea pig colon [Abstract]. FASEB. Vol. 4: A980.

Cooke, H.J., Frieling, T., Wood, J.D., and Palmer J.M. 1990. Electrical and synaptic behavior of colonic submucosal neurons in Trichinella spiralis and B-lactoglobulin-sensitized guinea pigs [Abstract]. Gastroenterology. Vol. 98: A352.

Cooke, H.J., 1991. Influence of calcitonin gene-related peptide (CGRP) on intestinal transport [Abstract]. Regl. Peptides. Vol. 34: 87.

Cooke, H.J. and Carey H.V. 1991. Intestinal secretion after bypass surgery [Abstract]. FASEB J.

Cooke, H.J. and Javed, N. 1991. Effect of leukotriene D4 on colonic ion transport in lactoglobulin-sensitized guinea pigs [Abstract]. Gastroenterology. Vol. 100: A708.

Cooke, H.J. and Wang Y.X. 1991. Comparison of effects of lactoglobulin and N-formyl-methionyl-leucyl-phenalanine (FMLP) on ion transport in the colon of milk sensitized guinea pigs [Abstract]. Gastroenterology. Vol. 100: A708.

Cooke, H.J. and Wang Y.Z. 1991. Effects of 5-hydroxytryptamine on ion transport in the guinea pig distal colon [Abstract]. FASEB. Vol. 54: A1062.

Cooke, H.J., Banwell, J., Frieling, T., and Arnold, M. 1991. Vasoactive intestinal polypeptide (VIP) augments colonic Cl- secretion evoked by distension-active neural reflex pathways [Abstract]. Gastroenterology. Vol. 100: A682.

Cooke, H.J., Frieling, T., and Wood J.D. 1991. Actions of 5-hydroxytryptamine (5-HT) on guinea-pig colonic submucosal neurons: 5-HTP, 5-HT3, and 5-HT4 receptos [Abstract]. Gastroenterology. Vol. 100: A443.

Cooke, H.J., Frieling, T., and Wood, J.D. 1991. Histamine evokes cyclical spike discharge in submucous neurons in guinea pig distal colon [Abstract]. J. Gastrointestinal Motil. Vol. 3: A181.

Cooke, H.J., Javed, N., and Wang, Y.Z. 1991. Mast cell inflammatory mediators stimulate acetylcholine release from submucosal neurons during intestinal anaphylaxis [Abstract]. Gastroenterology. Vol. 100: A453.

Cooke, H.J., Reddix-Cheri, R., and Grider, G.R. 1991. Release of vasoactive intestinal polypeptide (VIP) from submucosal neurons in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 100: A485.

Cooke, H.J., Rikihisa, Y., and Fertel, R. 1991. Loss of absorptive capacity for sodium and chloride as a course of diarrhea in Potomac Horse Fever [Abstract]. FASEB J. Vol. 5: A1138.

Cooke, H.J., and Javed, N.H. 1992. The mast cell mediator, histamine stimulates acetylcholine release associated with Cl- secretion in the guinea pig distal colon [Abstract]. Gastroenterology. Vol. 102: A928.

Cooke, H.J., and Reddix, R.A. 1992. Neurokinin NK1 receptors mediate substance P-induced secretion in guinea pig ileum [Abstract]. Gastroenterology. Vol. 102: A752.

Cooke, H.J., Frieling, T., Schermann, M., and Wood, J.D. 1992. Pre- and postsynaptic 2 adrenoreceptors on submucous neurons in the guinea pig colon [Abstract]. Gastroenterology. Vol. 102: A732.

Cooke, H.J., Wang Y.Z., and Rogers, R. 1992. Mechanisms of neural-immune system interactions [Abstract]. Dig. Dis. Sci. Vol. 37: 966.

Cooke, H.J., Wang, Y.Z., and Rogers, R. 1992. Histamine evokes coordinated cyclical patterns of muscle contraction associated with Cl- secretion in the guinea pig colon [Abstract]. Gastroenterology. Vol. 102: A532.

Cooke, H.J., Reddix, R.A., Mullet, D., and Fertel, R. 1993. Nitric oxide modulation of endothelin-evoked ion secretion in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 104: A849.

Cooke, H.J., Reddix, R.A., Wang, Y.Z., and Fertel, R. 1993. Activation of neural histamine H2 receptors evokes VIP release associated with recurrent cycles of Cl- secretion in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 104: A569.

Cooke, H.J., Wang, Y.Z., and Rogers, R. 1993. Sequential activation of secretion and large amplitude contractions by the H2 receptor agonist, dimaprit. [Abstract]. Gastroenterology. Vol. 104: A597.

Cooke, H.J., and Reddix, R.A. 1994. Endothelin-1 immunohistochemical distribution and receptors mediating secretion in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 106: A1046.

Cooke, H.J., and Wang, Y.Z. 1994. Histamine H2 receptor activation stimulates colonic secretion by activating intrinsic neural circuits containing tachykinin neurons in the guinea pig [Abstract]. Gastroenterology. Vol. 106: A850.

Cooke, H.J., Jhiang, S.M., and Fox, P. 1994. Cloning of histamine H2 receptor cDNAs in the gastrointestinal tract of the guinea pig by polymerase chain reaction (PCR). [Abstract]. Gastroenterology. Vol. 106: A804.

Cooke, H.J., Reddix, R.A., Mullet, D., and Fertel, R. 1994. Paracrine modulation of the colonic epithelium: role for nitric oxide and prostaglandins [Abstract]. Gastroenterology. Vol. 106: A264.

Cooke, H.J., Sidhu, M., and Wang, Y.Z. 1994. Mucosal stroking stimulates intrinsic, capsaicin-insensitive tachykinin neurons which regulate colonic secretion in the guinea pig [Abstract]. Gastroenterology. Vol. 106: A1050.

Cooke, H.J., Sidhu, M., and Wang, Y.Z. 1994. Submucous reflexes: Sensory transduction mechanisms and neural pathways influencing mucosal stroking-induced secretion in the guinea pig colon [Abstract]. Gastroenterology. Vol. 106: A1050.

Cooke, H.J., Zafirov, D.H., Xia, Y., and Wood, J.D. 1994. Actions of tumor necrosis factor (TNF) on electrical and synaptic behavior in the submucous plexus of the guinea-pig small intestine [Abstract]. Am Motility Meetings.

Cooke, H.J., and Sidhu, M. 1995. Multiple signaling messengers in secretory reflexes stimulated by mucosal stroking of the guinea pig colon [Abstract]. Gastroenterology. Vol. 108: A1006.

Cooke, H.J., and Wang, Y.Z. 1995. Multiple somatostatin receptor subtypes inhibit intestinal secretion triggered by histamine H2 receptor activation of sumbucosal neurons [Abstract]. Gastroenterology. Vol. 108: A1015.

Cooke, H.J., Fox, P., and Erbe, L. 1995. NK1 receptor gene expression in isolated enterocytes of the guinea pig colon: A role in axon reflexes? [Abstract]. Gastroenterology. Vol. 108: A600.

Cooke, H.J., Xia, Y. Zafirov, D.H., and Wood, J.D. 1995. Actions of tumor necrosis factor (TNF) on electrical and synaptic behavior in the submucous plexus of guinea pig small intestine [Abstract]. Gastroenterology. Vol. 108: A945.

Cooke, H.J., Xia, Y., Peck, O.C., and Wood J.D. 1995. Inflammatory mediators suppress inhibitory neurotransmission in morphologically identified neurons in the submucous plexus of the guinea-pig small intestine [Abstract]. Neurogastroenterology and Motility. Vol. 7, no. 4.

Cooke, H.J., Xia, Y., Zafirov, D.H., Mohanraj, P., and Wood, J.D. 1995. Identification of tachykinin receptors on neurons identified morphologically in the myenteric and submucous plexuses of guinea pig small intestine [Abstract]. Gastroenterology. Vol. 108: A1017.

Cooke, H.J., and Sidhu, M. 1996. Secretory reflexes triggered by mucosal stroking involve vasoactive intestinal polypeptide [Abstract]. Gastroenterology. Vol. 110: A758.

Cooke, H.J., and Wang, Y.Z. 1996. Signaling via a protein kinase C pathway modulates substance P secretory response in guinea pig distal colon [Abstract]. Gastroenterology. Vol. 110: A374.

Cooke, H.J., Fox, P., and Wolfe, S. 1996. Signaling from the nervous to the immune system occurs via NK1 receptor occupancy of mast cells [Abstract]. Gastroenterology. Vol. 110: A1071.

Cooke, H.J., Xia, Y., and Wood, J.D. 1996. Interleukin-1 beta and interleukin-6 excite neurons and suppress inhibitory noradrenergic neurotransmission in the submucous plexus of guinea-pig small intestine [Abstract]. Gastroenterology. Vol. 110: A783.

Cooke, H.J., Wang Y.Z., Sidhu, M., and Alferes, L. 1997. Selective activation of mucosal secretory reflexes by pulses of 5-hydroxytryptamine and substance P define the sequence of neurotransmitter/modulator release [Abstract]. Gastroenterology. Vol. 112: A849.

Cooke, H.J., Wang, Y.Z., O'Dorisio, T.M., Woltering, E.A., Coy, D.H., Murphy, W.A., and Gosh, P. 1997. Multi-tyrosinated somatostatin analog, WOC-3B, inhibits histamine H2 receptor-mediated cyclical chloride secretion in the guinea pig colon [Abstract]. Gastroenterology. Vol. 112: A1199.

Cooke, H.J., Wang, Y.Z., Alferes, L., O'Dorisio, M.S., Woltering, E.A., Coy, D.H., Murphy, W.A., and Gosh, P. 1998. Role for somatostatin receptors in discriminating between mechanosensitive release of 5-HT and PGE2 in the initiation of secretory reflexes in the guinea pig colon [Abstract]. Gastroenterology. Vol. 114: A858.

Cooke, H.J., Wang, Y.Z., Alferes, L., O'Dorisio, T.M., Woltering, E.A., Coy, D.H., Murphy, W.A., and Gosh, P. 1998. Release of paracrine mediators initiating secretory reflexes is

differentially regulated by a somatostatin analog in the guinea pig colon [Abstract]. Dig. Diseases and Sci. Vol. 73: 1853.

Cooke, H.J., Wang, Y.Z., Christofi, F.L., Liu, C.Y., and Zhang, H. 1998. Role for purinergic A1 receptors in submucosal secretory reflexes in the guinea pig colon [Abstract]. Gastroenterology. Vol. 114: A858.

Cooke, H.J., Xue, J., Christofi, F.L., Liu, C.Y., Goetzl, E.J., and Wang, Y.Z. 1998. Antisense oligonucleotide suppression of expression of VIP receptors in diverse intestinal cells [Abstract]. Gastroenterology. Vol. 114: A1192.

Cooke, H.J., and Wang, Y.Z. 1999. Calcitonin gene-related peptide receptor antagonist, CGRP 8-37 reduced neurally-evoked secretion in the guinea pig colon [Abstract]. Gastroenterology. Vol. 116: A1100.

Cooke, H.J., Christofi, F.L., Guzman, J., Xue, J., Liu, C.Y., Zhang, H., and Kim, M. 1999. Differential gene expression of adenosine A1, A2a, A2b, A3 receptors in the human small and large intestine [Abstract]. Gastroenterology. Vol. 116: A597.

Cooke, H.J., Kim, M., Raybould, H., Carey, H.V., and Javed, N.H. 1999. D-Glucose uptake by SGLT-1, the sodium/D-glucose cotransporter, is associated with 5-hydroxytryptamine (5-HT) release from human Bon cells [Abstract]. Gastroenterology. Vol. 116: A616.

Cooke, H.J., Christofi, F.L., Yu, J.G., Xue, J., Wang, Y.Z., and Kim, M. 2000. Adenosine A3 receptors are involved in the activation of an inhibitory neural motor pathway in rat colon [Abstract]. Drug Dev. Res. Vol. 50: 80.

Cooke, H.J., Guzman, J.E., Yu, J.G., Xue, J., Wang, Y.Z., Kim, M., and Christofi, F.L. 2000. Adenosine A3 receptor gene expression in intestinal tract of humans, rats, and guinea pigs [Abstract]. Drug Dev. Res. Vol. 50: 79.

Cooke, H.J., Kim, M. and Javed, J.H. 2000. G-protein cross-talk mediates adenosine's amplification of mechanically-activated 5-hydroxytryptamine release from BON cells [Abstract]. Drug Dev. Res. Vol. 50: 87.

Cooke, H.J., Kim, M., Javed, N.H., Christofi, F.L., Xue, J., and Raybould H. 2000. Adenosine acts at A1, A2a, and A2b receptors to modulate 5-hydroxytryptamine release from human BON cells [Abstract]. Gastroenterology. Vol. 118: A306.

Cooke, H.J., Kim, M., Javed, N.J., and Raybould, H. 2000. Adenosine A1 receptor agonist augments mechanically-evoked release of 5-hydoxytryptamine from Human BON cells [Abstract]. Gastroenterology. Vol. 118: A631.

Cooke, H.J., Kim, M., Javed, N.J., and Raybould, H.E. 2000. D-Glucose stimulates 5-hydroxytryptamine (5-HT) release from chemosensitive human BON cells via SGLT-1 [Abstract]. FASEB J.

Cooke, H.J.,Wang, Y.Z., Xue, J., Yu, J.G., and Christofi, F.L. 2000. P2 receptors mediate chloride secretory reflexes in guinea pig distal colon [Abstract]. Drug Dev. Res. Vol. 50: 53.

Cooke, H.J., Xue, J., and Christofi, F.L. 2000. Cloning and expression of the guinea pig vasoactive intestinal polypeptide receptor-1 [Abstract]. Gastroenterology. Vol. 118: A407.

Cooke, H.J.,Yu, J.G., Xue, J., Zhang, H., Wang, Y.Z., Kim, M., and Christofi, F.L. 2000. Neural adenosine A3 receptors are negatively coupled to neuromuscular transmission in rat colon [Abstract]. Gastroeneterology. Vol. 118: A304.

Cooke, H.J., Xue, J., and Wang, Y.Z. 2001. Modulation Cl- secretion by changing expression of vasoactive intestinal polypeptide-1 receptor (VIP 1R) in guinea pig distal colon in vitro [Abstract]. Gastroenterology. Vol. 120, no. Suppl. 1.

Cooke, H.J., and Kim, M. 2001. Caveolin-1 suppressed mechanically evoked activation of Gaq-coupled 5-HT release from BON cells [Abstract]. Gastroenterology. Vol. 120, no. Suppl. 1.

Cooke, H.J.,Kim, M., Javed, N.H., and Christofi, F.L. 2001. Mechanical stimulation of human BON cells: Gaq involvement in 5-HT release [Abstract]. Gastroenterology. Vol. 120, no. Suppl 1: 444.

Cooke, H.J., and Xue, J. 2002. VIP 1 receptors mediate 5-hydroxytryptamine release from human BON cells as a model of enterochromaffin cells [Abstract]. Gastroenterology. Vol. 112: A162.

Cooke, H.J., Guzman, J., Yu, J.G., Wiemelt, A.P., McMorris, A., and Christofi, F.L. 2002. Receptor activation visualization and quantitation of cAMP immunoreactivity in submucous neurons with diverse morphologies [Abstract]. Gastroenterology. Vol. 122: A48.

Cooke, H.J., Wang, Y.Z., Yu, J.G., Xue, J., and Christofi, F. 2002. Nucleotide release during mechanical stimulation modulates the coordinated neural reflex response to secretion and muscle contraction [Abstract]. Gastroenterology. Vol. 122: A161.

Cooke, H.J., Xue, J., Kim, M., Javed, N., Guzman, J., and Christofi, F. 2002. Endogenous nucleotides influence 5-hyroxytryptamine release in human BON cells [Abstract]. Gastroenterology. Vol. 112: A162.

Cooke, H.J., Yu, J.G., Wang, Y.Z., Xue, J., Javed, N., and Christofi, F.L. 2002. Nucleotides modulate intestinal secretory reflexes through the submucosal plexus [Abstract]. Gastroenterology. Vol. 112: A42.

Cooke H.J., Xue, J., Wang, Y.Z., Jeon, Y., and Christofi, F.L. 2003. Nucleotide activation of P2Y receptors on submucosal neurons regulates chloride secretion via prostaglandin-dependent and independent mechanisms [Abstract]. Gastroenterology. Vol. 124, no. 4 Suppl. 1: A342.

Cooke, H.J., Guzman, J., Palmer, J., Yu, J., Suntres, Z., Wisel, S. Mitchler, R., Hassanian, H., and Christofi, F.L. 2003. Amplification and immune modulation in the AC/cAMP signaling pathway leads to hyperexcitability in intrinsic primary afferent (AH) neurons of Trichinella spiralis infected guinea pigs [Abstract]. Gastroenterology. Vol. 124: A29.

Cooke, H.J., Guzman, J., Palmer, J., Yu, J., Suntres, Z., Xue, J., Wisel, S., Mitchler, R., Hassanain, H., and Christofi, F.L. 2003. Amplification in the AC/cAMP pathway leads to hyperexcitability in intrinsic primary afferent (AH) neurons in T. spiralis infected guinea pigs [Abstract]. Gastroenterology. Vol. 124: A29.

Cooke, H.J., Guzman, J., Yu, J.G., and Christofi, F.L. 2003. Cyclic AMP-visualized myenteric neurons in intact neural circuits have polarized projections for abnormal reflexes [Abstract]. Neurogastroenterology and Motility/Enteric Nervous System Meeting. Vol. 115. Banff, Canada: 196-237.

Cooke, H.J., Hassanian, H., and Christofi, F.L. 2003. Amplification in the AC/cAMP pathway leads to hyperexcitability in intrinsic primary afferent (AH) neurons in T. spiralis infected guinea pigs [Abstract]. Gastroenterology. Vol. 124, no. 4 Suppl 1: A29.

Cooke, H.J., Wunderlich, J.E., Xue, J., and Christofi, F.L. 2003. Mechanical stimulation of human carcinoid BON cells leads to 5-HT release via a phospholipase C/Ca signaling pathway [Abstract]. Gastroenterology.

Cooke, H.J., Wunderlich, J.E., Xue, J., Christofi, H.L. 2003. Mechanical stimulation of human carcinoid BON cells leads to 5-HT release via a phospholipase C/Ca signaling pathway [Abstract]. Gastroenterology. Vol. 124, no. 4 Suppl.1: A341.

Cooke, H.J., Xue, J., Wang, Y.Z., Jeon, Y., and Christofi, F.L. 2003. Nucleotide activation of P2Y receptors on submucosal neurons regulates chloride secretion via prostaglandins-dependent and independent mechanisms [Abstract]. Gastroenterology. Vol. 124: A341.

Cooke, H.J., Xue, J., Wang, Y.Z., Jeon, Y., and Christofi, F.L. 2003. Nucleotide activation of P2Y receptors on submucosal neurons regulates chloride secretion via prostaglandin-dependent and independent mechanisms [Abstract]. Gastroenterology. Vol. 124: A342.

Cooke, H.J., Xue, J., Wunderlich, J.E., Christofi, F.L., Wang, Y.Z., and Jeon, Y. 2003. Over-expressed human BON cell P2Y11 Rs in HEK-293 cells are coupled predominantly to a camp-dependent signaling pathway [Abstract]. Gastroenterology. Vol. 124, no. 4 Suppl.1: A341.

Cooke, H.J., Xue, J., Wunderlich, J.E., Christofi, F.L., Wang, Y.Z., and Jeon, Y. 2003. Over-expressed human BON cell P2Y11 Rs in HEK-293 cells are coupled predominantly to a camp-dependent signaling pathway [Abstract]. Gastroenterology. Vol. 124: A341.

Cooke, H.J., Chen, Z., Guzman, J.E., Yu, J.G., Grants, I., and Christofi, F.L. 2004. Elevation of intracellular cyclic AMP levels contributes to the excitability of myenteric AH/Dogiel Type II

and S/Dogiel Type I neurons with polarized projection [Abstract]. Gastroenterology. Vol. 126, no. 4 Suppl. 2: A276.

Cooke, H.J., Germano, P., Oh, D., Lieu, S., Siu, A., Le, S., Xue, J., and Pisegna J. 2004. PACAP stimulates signal transduction and proliferation in the BON neuroendocrine tumor cell line, via coupling to signaling pathways mediated by Gaq [Abstract]. Gastroenterology. Vol. 126, no. 4 Suppl.2: A415.

Cooke, H.J., Guzman, J.E., Javed, N.H., Cardounel, N.J., Kornacker, K., Yu, J.G., Grants, I., and Christofi, F.L. 2004. The A3 adenosine receptor agonist IB-MECA is beneficial in the TNBS-Colitis [Abstract]. Gastroenterology. Vol. 126, no. 4 Suppl. 2: A282.

Cooke, H.J., Wunderlich, J., and Christofi, F. 2004. Mechanosensitivity in human enterochromaffin cells involved autocrine activation of P2Y receptors by endogenous nucleotides leading to 5-HT release [Abstract]. Purines 2004 Meeting. Chapel Hill, N. Carolina.

Cooke, H.J., Wunderlich, J.E., Xue, J., and Christofi, F.L. 2004. Visualization and mapping of mechanosensitive P2X receptors in the human BON- enterochromaffin cell model [Abstract]. Gastroenterology. Vol. 126, no. 4 Suppl 2: A412.

Cooke, H.J., Wunderlich, J.E., Xue, J., Kim, M., Javed, N.H., Christofi, F., Suntres, Z., Yu, J.G., and Grants, I. 2004. Mechanical stimulation of human enterochromaffin-BON cells release adenosine to act at A3 receptors to modulate 5-HT release [Abstract]. Gastroenterology. Vol. 126, no. 4 Suppl. 2: A160.

Cooke, H.J., Xue, J., Christofi, F.L., Wunderlich, J., Wang, Y.Z., and Jeon, Y.C. 2004. Homing in on ATP's role in 5-hydroxytryptamine release in mechanosensitive carcinoid BON cells [Abstract]. Gastroenterology. Vol. 126, no. 4 Suppl 2: A277.

Cooke, H.J., Boserov, A., Wang, Y.Z., Javed, N., and Christofi, F.L. 2005. Comparison of adenosine A1 receptor activation on repetitive reflex Cl- secretion coordinated with repetitive muscle activity measured by Sonomicrometry and force transducer tension. [Abstract]. Gastroenterology. Vol. 128, no. 4 Suppl.2: A608.

Cooke, H.J., Chen, Z., Wunderlich, J., Yu, J.G., Guzman, J., Grants, I., and Christofi, F.L. 2005. Cyclic AMP-dependent signaling predominates in descending excitatory synaptic pathways in the submucous plexus of the rat distal colon [Abstract]. Gastroenterology. Vol. 128, no. 4 Suppl. 2: A642.

Cooke, H.J., Guzman, J., Chen, Z., Yu, J.G., Javed, N., Grants, I., Grider, I., and Christofi, F.L. 2005. Neuronal cyclic AMP signaling is polarized for descending reflexes in the myenteric plexus of the guinea-pig small intestine [Abstract]. Gastroenterology. Vol. 128, no. 4 Suppl 2: A41.

Cooke, H.J., Wunderlich, J.E., Yu, J.G., Chen, Z., Guzman, J., Grants, I., Melvin, S., and Christofi, F.L. 2005. Optical recording of synapitc Ca2+ signals, cyclic AMP visualization and

purinergic transmission in the human enteric nervous system [Abstract]. Gastroenterology. Vol. 128, no. 4 Suppl. 2: A87.

Bozarov, Andrey; Wang, Yu-Zhong; Yu, Jun-Ge; Cooke, Helen J.; Christofi, Fievos L. 2006. Endogenous adenosine acts at A1 or A3 inhibitory receptors to modulate the stereotype neural-motor behavior of the gut triggered by histamine or distension [Abstract]. Gastroenterology. Vol. 130, no. 4 Suppl. 2: A29.

Wunderlich, J.E., Cooke H.J., Chen, Z.Y., Jun, G., Grants, I., Hinshaw, K., Melvin, S., and Christofi, F.L. 2006. Adenosimergic A3 receptor regulation in the human enteric nervous system [Abstract]. Gastroenterology. Vol. 130, no. 4 Suppl. 2: A30.

Xue J., Christofi, F., Cooke, H.J. 2007. Mechanosensitive release of calcium or 5-HT: P2Y1 receptor over-expression in human BON cells [Abstract]. Gastroenterology. Vol. 132: A242