publications | ESMI members06/2014 – 08/2014

imaging life

clinicalrelated papers

This list of publications is a compilation of references – published quarterly and provided by the members of the European Society for Molecular Imaging – ESMI. It aims to reflect the interdisciplinarity within the ESMI and accordingly within the broad field of imaging science. It should provide the societies’ members with the possibility to present and disseminate their work also with the aim to foster knowledge exchange between the disciplines.

The list is neither complete nor extensively reviewed. The list is sorted by first author and - to provide you with a better readability - by the categories clinical, preclinical, probe development, and technology/methodology related papers. This categorisation might not reflect in any case the entire work behind.

THANKS to all of you who contributed to this issue! Your publications between June and August 2014:

Brom M, Boerman O, Gotthardt M, Oyen WJ. Preclinical Studies of SPECT and PET Tracers for NET. PET Clin. 2014, 9, 63-69.

Brouwer OR, van den Berg NS, Mathéron HM, Wendler T, van der Poel HG, Horenblas S, Valdés Olmos RA, van Leeu-wen FW. Feasibility of intraoperative navigation to the sentinel node in the groin using preoperatively acquired SPECT/CTdata; transferring functional imaging to the operating room. J Urol. 2014 Jul 24. pii: S0022-5347(14)04046-4.

Danad I, Raijmakers PG, Harms HJ, Heymans MW, van Royen N, Lubberink M, Boellaard R, van Rossum AC, Lammertsma AA, Knaapen P. Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfu-sion gradient: a [15O]H2O PET study. Eur Heart J. 2014 Aug 14;35(31):2094-105.

De Raedt N, Gheysens O, Nackaerts K, Dooms C, De Ruysscher D, Deroose CM. Small lesion, severe consequences : an in-triguing ventilation-perfusion scintigraphy. American Journal of Respiratory and Critical Care Medicine 2014;190(4):e12-3

Honka H, Hannukainen JC, Tarkia M, Karlsson H, Saunavaara V, Salminen P, Soinio M, Mikkola K, Kudomi N, Oikonen V, Haaparanta-Solin M, Roivainen A, Parkkola R, Iozzo P, Nuutila P. Pancreatic metabolism, blood flow and β-cell function in obese humans. J Clin Endocrinol Metab 2014 June, 99, E981-E990

Kairemo K, Rasulova N, Partanen K, Joensuu T.Preliminary clinical experience of trans-1-Amino-3-(18)F-fluorocyclobu-tanecarboxylic Acid (anti-(18)F-FACBC) PET/CT imaging in prostate cancer patients.Biomed Res Int. 2014;2014:305182.

Kaijser J, Vandecaveye V, Deroose CM, Rockall A, Thomassin-Naggara I, Bourne T, Timmerman D. Imaging technique for the presurgical diagnosis of adnexal tumours. Clinical Obstetrics & Gynecology, 2014 ;28(5):683-95

imaging life

publications 06/2014 – 08/2014

clinical related papersKeunen O, Taxt T, Grüner R, Lund-Johansen M, Tonn JC, Pavlin T, Bjerkvig R, Niclou SP, Thorsen F. Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. Adv Drug Deliv Rev. 2014 Jul 28.

KleinJan GH, van den Berg NS, Brouwer OR, de Jong J, Acar C, Wit EM, Vegt E, van der Noort V, Valdés Olmos RA, van Leeu-wen FW, van der Poel HG. Optimisation of Fluorescence Guidance During Robot-assisted Laparoscopic Sentinel Node Biopsy for Prostate Cancer. Eur Urol. 2014 Aug 1. pii: S0302-2838(14)00654-X

Lutzweiler C, Meier R, Rummeny E, Ntziachristos V, Razansky D. Real-time optoacoustic tomography of indocyanine green perfusion and oxygenation parameters in human finger vasculature. Opt Lett. 2014, 39(14):4061-4

Meier R, Kraus T, Schaeffeler C, Torka S, Schlitter M, Specht K, Haller B, Waldt S, Rechl H, Rummeny EJ, Woertler K. Bone marrow edema on MR imaging indicates ARCO stage 3 disease in patients with AVN of the femoral head.Eur Radiol. 2014 Sep;24(9):2271-8.

Mohajerani P, Koch M, Thürmel K, Haller B, Rummeny EJ, Ntziachristos V, Meier R. Fluorescence-aided Tomographic Imag-ing of Synovitis in the Human Finger.Radiology. 2014 Sep;272(3):865-874.

Nguyen VL, Backes WH, Kooi ME, Wishaupt MC, Hellenthal FA, Bosboom EM, van der Geest RJ, Schurink GW, Leiner T. Quantification of abdominal aortic aneurysm wall enhancement with dynamic contrast-enhanced MRI: feasibility, re-producibility, and initial experience. J Magn Reson Imaging. 2014, 39, 1449-56.

Schöffski P, Deroose CM, Gheysens O, Lips N, Slabbaert K, Vancleynenbreugel B, Moerman P, Peetermans E. The more you look, the more you find : challenging results on PFG-PET CT in a patient with neurofibromatosis type I. BMC Medical Imaging. 2014;14:19

Truijman MT, Kooi ME, van Dijk AC, de Rotte AA, van der Kolk AG, Liem MI, Schreuder FH, Boersma E, Mess WH, van Oostenbrugge RJ, Koudstaal PJ, Kappelle LJ, Nederkoorn PJ, Nederveen AJ, Hendrikse J, van der Steen AF, Daemen MJ, van der Lugt A.Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques. Int J Stroke. 2014, 9, 747-54.

Van Cauter S, De Keyzer F, Sima DM, Croitor Sava A, D’Arco F, Veraart J, Peeters RR, Leemans A, Van Gool S, Wilms G, De-maerel P, Van Huffel S, Sunaert S, Himmelreich U. Integrating diffusion kurtosis imaging, dynamic susceptibility-weighted contrast-enhanced MRI, and short echo time chemical shift imaging for grading gliomas. Neuro-Oncology 2014 July; 16(7): 1010-1021.

Witjas-Paalberends ER, Güçlü A, Germans T, Knaapen P, Harms HJ, Vermeer AMC, Christiaans I, Wilde AAM, dos Remedios C, Lammertsma AA, van Rossum AC, Stienen GJM, van Slegtenhorst M, Schinkel AF, Michels M, Ho CY, Poggesi C, van der Velden J. Gene-specific increase in energetic cost of contraction in hypertrophic cardiomyopathy caused by thick fila-ment mutations. Cardiovasc Res. 2014 Jul 15;103(2):248-57.

Wulkersdorfer B, Wanek T, Bauer M, Zeitlinger M, Müller M, Langer O. Using Positron Emission Tomography to Study Transporter-Mediated Drug-Drug Interactions in Tissues. Clinical Pharmacology & Therapeutics. 2014, 96(2).206-213.

Zwan MD, Ossenkoppele R, Tolboom N, Beunders AJM, Kloet RW, Adriaanse SM, Boellaard R, Windhorst AD, Raijmakers P, Adams H, Lammertsma AA, Scheltens P, van der Flier WM, van Berckel BNM. Comparison of simplified parametric meth-ods for visual interpretation of 11C-Pittsburgh compound-B PET images. J Nucl Med. 2014 Jun 4;55(8):1305-7.

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imaging life

publications 06/2014 – 08/2014

preclinicalrelated papersAhtinen H, Kulkova J, Lindholm L, Eerola E, Hakanen A, Moritz N, Söderström M, Saanijoki T, Jalkanen J, Roivainen A, Aro H. 68Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections. EJNMMI Res 2014, 4, 45

Aswendt M, Adamczak J, Tennstaedt A. A review of novel optical imaging strategies of the stroke pathology and stem cell therapy in stroke. Front. Cell. Neurosci. 8:226.

Bernards N, Pottier G, Thézé B, Dollé F, Boisgard R. In vivo Evaluation of Inflammatory Bowel Disease with the Aid of μPET and the Translocator Protein 18 kDa Radioligand [18F]DPA-714. Mol Imaging Biol. 2014 Jul 12

Beziere N, von Schacky C, Kosanke Y, Kimm M, Nunes A, Licha K, Aichler M, Walch A, Rummeny EJ, Ntziachristos V, Meier R. Optoacoustic imaging and staging of arthritic inflammation. Arthritis&Rheumatism. Arthritis Rheumatol. 2014 Aug;66(8):2071-8.

Bianchi A, Dufort S, Fortin PY, Lux F, Raffard G, Tassali N, Tillement O, Coll JL, Crémillieux Y. In vivo MRI for effective non-invasive detection and follow-up of an orthotopic mouse model of lung cancer. NMR Biomed 2014 Aug., 27(8), 971-9

Bianchi A, Dufort S, Lux F, Courtois A, Tillement O, Coll JL, Crémillieux Y. Quantitative biodistribution and pharmacokinetics of multimodal gadolinium-based nanoparticles for lungs using ultrashort TE MRI. MAGMA 2014 Aug., 27(4), 303-16

Bianchi A, Dufort S, Lux F, Fortin PY, Tassali N, Tillement O, Coll JL, Crémillieux Y. Targeting and in vivo imaging of non-small-cell lung cancer using nebulized multimodal contrast agents. Proc Natl Acad Sci USA 2014 June, 111(25), 9247-52

Biesemann N, Mendler L, Wietelmann A, Hermann S, Schafers M, Kruger M, Boettger T, Borchardt T, Braun T. Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res 2014, 115, 296–310

Bogdanović R, Syvänen S, Michler C, Russmann V, Eriksson J, Windhorst A, Lammertsma A, de Lange E, Voskuyl R, Potschka H. (R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model. Neuropharmacol. 2014 Oct;85:104-12.

Bolcaen J, Descamps B, Deblaere K, Boterberg T, Hallaert G, Van den Broecke C, Decrock E, Vral A, Leybaert L, Vanhove C, Goethals I. MRI-guided 3D conformal arc micro-irradiation of a F98 glioblastoma rat model using the Small Animal Radiation Research Platform (SARRP).J Neurooncol 2014 Jul 29.

Cavic M, Grozdanovic MM, Bajic A, Jankovic R, Andjus PR, Gavrovic-Jankulovic M. The effect of kiwifruit (Actinidia deliciosa) cysteine protease actinidin on the occludin tight junction network in T84 intestinal epithelial cells. Food Chem Toxicol. 2014, 72C, 61-68

Chatterjee S, Wieczorek C, Schöttle J, Siobal M, Hinze Y, Franz T, Florin A, Adamczak J, Heukamp LC, Neumaier B, Ullrich RT. Transient antiangiogenic treatment improves delivery of cytotoxic compounds and therapeutic outcome in lung cancer. Cancer Research 2014, 74, 2816-2824

Colombo E, Dario MD, Capitolo E, Chaabane L, Newcombe J, Martino G, Farina C. Fingolimod may support neuroprotection via blockade of astrocyte nitric oxide. Ann Neurol. 2014 Jul 4.

D’huyvetter M.; Xavier C.; Caveliers V.; Lahoutte T.; Muyldermans S.; Devoogdt N. (2014) Radiolabeled nanobodies as theranostic tools in targeted radionuclide therapy of cancer. Expert Opinion on Drug Delivery.

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imaging life

publications 06/2014 – 08/2014

de Paula Faria D, Vlaming MLH, Copray SC, Tielen F, Anthonijsz HJ, Sijbesma JW, Buchpiguel CA, Dierckx RA, van der Hoorn JW, de Vries EF. PET Imaging of Disease Progression and Treatment Effects in the Experimental Autoimmune Encephalomyelitis Rat Model. June 2014,J Nucl Med 2014, 55, 1330-1335.

Egger C, Gérard C, Vidotto N, Accart N, Cannet C, Dunbar A, Tigani B, Piaia A, Jarai G, Jarman E, Schmid HA, Beckmann N. Lung volume quantified by MRI reflects extracellular-matrix deposition and altered pulmonary function in bleomycin models of fibrosis: effects of SOM230. Am J Physiol Lung Cell Mol Physiol 2014, 306, L1064-L1077. Juni 2014

Fantappiè L, de Santis M, Chiarot E, Carboni F, Bensi G, Jousson O, Margarit I, Grandi G. Antibody-mediated immunity induced by engineered Escherichia coli OMVs carrying heterologous antigens in their lumen. J Extracell Vesicles 2014, Aug 11;3.

Ferrarese R, Harsh G R T, Yadav A K, Bug E, Maticzka D, Reichardt W, Dombrowski S M, Miller T E, Masilamani A P, Dai F, Kim H, Hadler M, Scholtens D M, Yu I L, Beck J, Srinivasasainagendra V, Costa F, Baxan N, Pfeifer D, von Elverfeldt D, Backofen R, Weyerbrock A, Duarte C W, He X, Prinz M, Chandler J P, Vogel H, Chakravarti A, Rich J N, Carro M S, Bredel M. Lineage-specific splicing of a brain-enriched alternative exon promotes glioblastoma progression. J Clin Invest, 2014, 124(7), 2861-2876.

Ferrari G, Bignami F, Giacomini C, Capitolo E, Comi G, Chaabane L, Rama P. Ocular surface injury induces inflammation in the brain: in vivo and ex-vivo evidence of a corneal-trigeminal axis. Invest Ophthalmol Vis Sci. 2014 Aug 21.

Ganesan MK, Jovanovic M, Secerov B, Ignjatovic M, Bilban M, Pavle A, Refaei AE, Jung G, Li L, Sase A, Chen W, Bacic G, Lubec G. Radiation protection from whole-body gamma irradiation (6.7 Gy): behavioural effects and brain protein-level changes by an aminothiol compound GL2011 in the Wistar rat. Amino Acids. 2014, 46,1681-1696

Goethals LR.; Bos T.; Baeyens L.; De Geeter F.; Devoogdt N.; Lahoutte T. (2014) Camelid reporter gene imaging: A generic method for in vivo cell tracking. EJNMMI Research. 4, 32.

Gravier J, Sancey L, Hirsjärvi S, Rustique E, Passirani C, Benoît JP, Coll JL, Texier I. FRET Imaging Approaches for in Vitro and in Vivo Characterization of Synthetic Lipid Nanoparticles. Molecular Pharmaceutics, 2014 Aug.

Hartwig K, Fackler V, Jaksch-Bogensperger H, Winter S, Furtner T, Couillard-Despres S, Meier D, Moessler H, Aigner L. Cerebrolysin protects PC12 cells from CoCl2-induced hypoxia employing GSK3β signaling. Int J Dev Neurosci. 2014 Aug 2.

Kadjane P, Platas-Iglesias C, Boehm-Sturm P, Truffault V, Hagberg GE, Hoehn M, Logothetis N, Angelovski G. Dual-frequency Calcium-responsive MRI agents. Chemistry 2014, 20, 7351-7362

Keunen O, Taxt T, Grüner R, Lund-Johansen M, Tonn JC, Pavlin T, Bjerkvig R, Niclou SP, Thorsen F. Multimodal imaging of gliomas in the context of evolving cellular and molecular therapies. Adv Drug Deliv Rev. 2014 Jul 28.

Khamis RY, Woollard KJ, Hyde GD, Boyle JJ, Bicknell C, Hara T, Mauskapf A, Granger DW, Johnson JL, Ntziachristos V, Matthews PM, Jaffer FA, Haskard DO. C Development of Whole Body and Intravascular Near-infrared Optical Molecular Imaging of Markers of Plaque Vulnerablity in Atherosclerosis. Heart. 2014 Jun;100 Suppl 3:A128.

Kiviniemi A, Gardberg M, Autio A, Li X-G, Liljenbäck H, Heuser VD, Käkelä M, Sipilä H, Kurkipuro J, Ylä-Herttuala S, Knuuti J, Minn H, Roivainen A. Feasibility of experimental BT4C glioma models for somatostatin receptor 2 targeted therapies. Acta Oncol 2014, 53, 1125–1134

Kossatz S., Ludwig R., Dähring H., Ettelt V., Rimkus G., Marciello M., Salas G., Patel V., Teran F. J., Hilger I. High Therapeutic Efficiency of Magnetic Hyperthermia in Xenograft Models Achieved with Moderate Temperature Increases in the Tumor Area. Pharmaceutical Research, June 2014

preclinical related papers

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imaging life

publications 06/2014 – 08/2014

preclinical related papersKovacs Z, Werner B, Rassi A, Sass JO, Martin-Fiori E, Bernasconi M. Prolonged survival upon ultrasound-enhanced doxorubicin delivery in two syngenic glioblastoma mouse models.Journal of Controlled Release 2014, 187, 74-82

Laine AL, Gravier J, Henry M, Sancey L, Béjaud J, Pancani E, Wiber M, Texier I, Coll JL, Benoit JP, Passirani C. Conventional versus stealth lipid nanoparticles: formulation and in vivo fate prediction through FRET monitoring. Journal of Controlled Release 2014, 188, 1-8.

Landgraf L., Ernst P., Schick I., Köhler O., Oehring H., Tremel W., Hilger I. (2014) Anti-oxidative effects and harmlessness of asymmetric Au@Fe3O4 Janus particles on human blood cells. Biomaterials, Volume 35, Issue 25, August 2014, Pages 6986–6997

Le Duc G, Roux S, Paruta Tuarez A, Dufort S, Marais A, Truillet C, Sancey L, Perriat P, Lux F, Tillement O. Advantages of gadolinium based ultrasmall nanoparticles vs molecular gadolinium chelates for radiotherapy guided by MRI for glioma treatment. Cancer Nanotechnology 2014 5(4).

Lütje S, Rijpkema M, Helfrich W, Oyen WJ, Boerman OC. Targeted Radionuclide and Fluorescence Dual-modality Imaging of Cancer: Preclinical Advances and Clinical Translation. Mol Imaging Biol. 2014

Marschallinger J, Krampert M, Couillard-Despres S, Heuchel R, Bogdahn U, Aigner L. Age-dependent and differential effects of Smad7ΔEx1 on neural progenitor cell proliferation and on neurogenesis. Exp Gerontol. 2014, 57C:149-154.

Mathijs I.; Xavier C.; Peleman C.; Caveliers V.; Brom M.; Gotthardt M.; Herrera PL.; Lahoutte T.; Bouwens L. (2014) A standardized method for in vivo mouse pancreas imaging and semiquantitative ß cell mass measurement by dual isotope SPECT. Mol Imaging Biol. 2014 Jul 29

Mechling A, Hübner N, Lee H-L, Hennig J, von Elverfeldt D, Harsan L-A. Fine-grained Mapping of Mouse Brain Functional Connectivity with Resting-State fMRI. Neuroimage, Aug 2014, 96, 203-215

Morani F, Phadngam S, Follo C, Titone R, Aimaretti G, Galetto A, Alabiso O, Isidoro C. PTEN regulates plasma membrane expression of glucose transporter 1 and glucose uptake in thyroid cancer cells. J Mol Endocrinol. 2014 Oct;53(2):247-58. Epub 2014 Aug 14.

Müller A, Chiotellis A, Keller C, Ametamey SM, Schibli R, Mu L, Krämer SD. Imaging tumour ATB0,+ transport activity by PET with the cationic amino acid O-2((2-[18F]fluoroethyl)methyl-amino)ethyltyrosine. Mol Imaging Biol. 2014,16, 412 - 20.

Müller A, Krämer SD, Meletta R, Beck K, Selivanova SV, Rancic Z, Kaufmann PA, Vos B, Meding J, Stellfeld T, Heinrich TK, Bauser M, Hütter J, Dinkelborg LM, Schibli R, Ametamey SM. Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability. Nucl Med Biol. 2014,41, 562-569.

Müller A, Mu L, Meletta R, Beck K, Rancic Z, Drandarov K, Kaufmann PA, Ametamey SM, Schibli R, Borel N, Krämer SD. Towards non-invasive imaging of vulnerable atherosclerotic plaques by targeting co-stimulatory molecules. Int J Cardiol. 2014, 174,503-15.

Murillo MM, Zelenay S, Nye E, Castellano E, Lassailly F, Stamp G, Downward J. RAS interaction with PI3K p110? is required for tumor-induced angiogenesis. J Clin Invest. 2014,24,3601-11

Muselaers CH, Oosterwijk E, Bos DL, Oyen WJ, Mulders PF, Boerman OC. Optimizing lutetium 177-anti-carbonic anhydrase IX radioimmunotherapy in an intraperitoneal clear cell renal cell carcinoma xenograft model. Mol Imaging. 2014, 13, 1-7.

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imaging life

publications 06/2014 – 08/2014

preclinical related papers

Oliveras-Salvá M., Macchi F., Coessens V., Deleersnijder A., Gérard M., Van der Perren A., Van den Haute C., Baekelandt V. α-synuclein-induced neuropathology and neurodegeneration is exacerbated in PINK1 knockout mice. Neurobiol Aging. 2014 Jun 14.

Ooms M, Rietjens R, Rangarajan JR, Vunckx K, Valdeolivas S, Maes F, Himmelreich U, Fernandez-Ruiz J, Bormans G, Van Laere K, Casteels C. Early decrease of type 1 cannabinoid receptor binding and phosphodiesterase 10A activity in vivo in R6/2 Huntington mice. Neurobiol Aging. 2014 Jun 16. j.neurobiolaging.2014.06.010.

Pizzitola I, Anjos-Afonso F, Rouault-Pierre K, Lassailly F, Tettamanti S, Spinelli O, Biondi A, Biagi E, Bonnet D.Chimeric antigen receptors against CD33/CD123 antigens efficiently target primary acute myeloid leukemia cells in vivo. Leukemia, 2014,28, 1596-605

Poole DS, Plenge E, Poot DH, Lakke EA, Niessen WJ, Meijering E, van der Weerd L. Three-dimensional inversion recovery manganese-enhanced MRI of mouse brain using super-resolution reconstruction to visualize nuclei involved in higher brain function. NMR Biomed. 2014 Jul;27(7):749-59.

Put S.; Westhovens R.; Lahoutte T.; Matthys P. (2014) Molecular imaging of rheumatoid arthritis: Emerging markers, tools, and techniques. Arthritis Research and Therapy. 16(2), 208.

Rijpkema M, Oyen WJ, Bos D, Franssen GM, Goldenberg DM, Boerman OC. SPECT- and Fluorescence Image-Guided Surgery Using a Dual-Labeled Carcinoembryonic Antigen-Targeting Antibody. J Nucl Med. 2014

Rinne P, Silvola JM, Hellberg S, Ståhle M, Liljenbäck H, Salomäki H, Koskinen E, Nuutinen S, Saukko P, Knuuti J, Saraste A, Roivainen A, Savontaus E. Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice. Arterioscler Thromb Vasc Biol 2014 July, 34, 1346-1354

Riva N, Chaabane L, Peviani M, Ungaro D, Domi T, Dina G, Bianchi F, Spano G, Cerri F, Podini P, Corbo M, Carro UD, Comi G, Bendotti C, Quattrini A. Defining peripheral nervous system dysfunction in the SOD-1G93A transgenic rat model of amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2014 Jul;73(7):658-70.

Rotheneichner P, Lange S, O‘Sullivan A, Marschallinger J, Zaunmair P, Geretsegger C, Aigner L, Couillard-Despres S. Hippocampal neurogenesis and antidepressive therapy: shocking relations. Neural Plast. 2014;2014:723915.

Rüger R., Tansi F. L., Rabenhold M., Steiniger F., Kontermann R. E., Fahr A., Hilger I. (2014) In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-Immunoliposomes. Journal of Controlled, Volume 186, 28 July 2014, Pages 1–10

Sancey L, Lux F, Kotb S, Roux S, Dufort S, Bianchi A, Crémillieux Y, Fries P, Coll JL, Rodriguez-Lafrasse C, Janier M, Dutreix M, Barberi-Heyob M, Boschetti F, Denat F, Louis C, Porcel E, Lacombe S, Le Duc G, Deutsch E, Perfettini JL, Detappe A, Verry C, Berbeco R, Butterworth KT, McMahon SJ, Prise KM, Perriat P, Tillement O. The use of theranostic gadolinium-based nanoprobes to improve radiotherapy efficacy. Br J Radiol. 2014: 20140134.

Snellman A, Rokka J, López-Picón FR, Eskola O, Salmona M, Forloni G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M. In vivo imaging of beta-amyloid deposition in mouse models od Alzheimer‘s disease with a high specific activity PET imaging agent [18F]flutemetamol. EJNMMI Research 2014, 4:37.

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imaging life

publications 06/2014 – 08/2014

Swales JG, Tucker JW, Strittmatter N, Nilsson A, Cobice D, Clench MR, Mackay CL, Andren PE, Takáts Z, Webborn PJ, Goodwin RJ. Mass Spectrometry Imaging of Cassette-Dosed Drugs for Higher Throughput Pharmacokinetic and Biodistribution Analysis. Anal Chem. 2014 Aug 8.

van Rij CM, Frielink C, Goldenberg DM, Sharkey RM, Franssen GM, Lütje S, McBride WJ, Oyen WJ, Boerman OC. Pretargeted ImmunoPET of Prostate Cancer with an Anti-TROP-2 x Anti-HSG Bispecific Antibody in Mice with PC3 Xenografts. Mol Imaging Biol. 2014, 25.

Vandeputte C, Reumers V, Aelvoet S-A, Thiry I, De Swaef S, Van den Haute C, Pascual-Brazo J, Farr T, Vande Velde G, Hoehn M, Himmelreich U, Van Laere K, Debyser Z, Gijbers R, BaekelandtV. Bioluminescence imaging of stroke-induced endogenous neural stem cell response. Neurobiology of Disease 2014, 69, 144-155

Verdurand M, Dalton VS, Nguyen V, Grégoire MC, Zahra D, Wyatt N, Burgess L, Greguric I, Zavitsanou K. Prenatal poly I:C age-dependently alters cannabinoid type 1 receptors in offspring: a longitudinal small animal PET study using [(18)F]MK-9470. Experimental Neurology 2014 Jul, 257, 162-169.

Voelkl J, Pakladok T, Lin Y, Viereck R, Lebedeva A, Kukuk D, Pichler BJ, Alesutan I, Lang F. Up-Regulation of Hepatic Alpha-2-HS-Glycoprotein Transcription by Testosterone via Androgen Receptor Activation. Cell Physiol Biochem. 2014;33(6):1911-1920.

Vogl T, Eisenblatter M, Voller T, Zenker S, Hermann S, van Lent P, Faust A, Geyer C, Petersen B, Roebrock K, Schäfers M, Bremer C, Roth J. Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity. Nat Commun 2014, 5, 4593

von Elverfeldt D, Maier A, Duerschmied D, Braig M, Neudorfer I, Menza M, Idzko M, Zirlik A, Heidt T, Mauler M, Bode C, Peter K, von zur Muhlen C. Dual contrast molecular imaging allows noninvasive characterization of myocardial ischemia-reperfusion injury after coronary vessel occlusion in mice by MRI. Circulation 2014, 130(8), 676-687

Wang J.; Hendrix A.; Hernot S.; Lemaire M.; De Bruyne E.; Van Valckenborgh E.; Lahoutte T.; De Wever O.; Vanderkerken K.; Menu E. (2014) Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood. 124(4), 555-566.

Wenning C, Kloth C, Kuhlmann MT, Jacobs AH, Schober O, Hermann S, Schäfers MA. Serial F-18-FDG PET/CT distinguishes inflamed from stable plaque phenotypes in shear-stress induced murine atherosclerosis. Atherosclerosis 2014;234(2):276-82.

Wolf D, Jehle F, Michel N A, Bukosza E N, Rivera J, Chen Y C, Hoppe N, Dufner B, Rodriguez A O, Colberg C, Nieto L, Rupprecht B, Wiedemann A, Schulte L, Peikert A, Bassler N, Lozhkin A, Hergeth S P, Stachon P, Hilgendorf I, Willecke F, von zur Muhlen C, von Elverfeldt D, Binder C J, Aichele P, Varo N, Febbraio M A, Libby P, Bode C, Peter K, Zirlik A. Coinhibitory Suppression of T Cell Activation by CD40 Protects Against Obesity and Adipose Tissue Inflammation in Mice. Circulation 2014, 129(23), 2414-2425

preclinical related papers

7

imaging life

publications 06/2014 – 08/2014

probe developmentrelated papers

Calcio Gaudino E, Tagliapietra S, Martina K, Barge A, Lolli M, Terreno E, Lembo D, Cravotto G.A novel SWCNT platform bear-ing DOTA and β-cyclodextrin units. “One shot” multidecoration under microwave irradiation. Org Biomol Chem. 2014, 14, 4708-4715

Canapè C, Catanzaro G, Terreno E, Karlsson M, Lerche MH, Jensen PR. Probing treatment response of glutaminolytic pros-tate cancer cells to natural drugs with hyperpolarized [5-13 C]glutamine. Magn Reson Med. 2014

Chiotellis A, Müller A, Mu L, Keller C, Schibli R, Krämer SD, Ametamey SM. Synthesis and biological evaluation of 18F-labeled fluoroethoxy tryptophan analogues as potential PET tumor imaging agents. Mol Pharm. 2014 Jul 14.

Chiotellis A, Müller A, Weyermann K, Leutwiler DS, Schibli R, Ametamey SM, Krämer SD, Mu L. Synthesis and preliminary biological evaluation of O-2((2-[(18)F]fluoroethyl) methylamino)ethyltyrosine ([ (18)F]FEMAET) as a potential cationic amino acid PET tracer for tumor imaging. Amino Acids. 2014, 46, 1947-1959.

Christiaans JAM, Klein PJ, Metaxas A, Kooijman EJM, Schuit RC, Leysen JE, Lammertsma AA, van Berckel BNM, Windhorst AD. Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[11C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors. Nucl Med Biol. 2014 Sep;41(8):670-80.

Delbianco M, Sadovnikova V, Bourrier E, Lamarque L Zwier JM, Parker D, Bright, highly water soluble triazacyclononane europium complexes to detect ligand binding with time-resolved FRET microscopy. Angew Chem Int Ed Engl. 2014 Aug 12.

Denk C, Svatunek D, Filip T, Wanek T, Lumpi D, Fröhlich J, Kuntner C, Mikula H. Development of a 18F-labeled tetrazine with favorable pharmacokinetics for bioorthogonal PET imaging. Angewandte Chemie International Edition 2014, in press

Ferrauto G, Carniato F, Tei F, Hu H, Aime S, Botta M. MRI nanoprobes based on chemical exchange saturation transfer: LnIII chelates anchored on the surface of mesoporous silica nanoparticles. Nanoscale 2014 Aug; 6: 9604–9607

Ho CJ, Blasundaram G, Driessen W, McLaren R, Wong CL, Dinish US, Attia AB, Ntziachristos V, Olivo M. Multifunctional photosensitizer-based contrast agents for photoacoustic imaging. Sci Rep 2014, 4;5342

Jafari S, Diou O, Mamou J, Renault G, Fattal E, Tsapis N, Bridal SL, High frequency (20 to 40 MHz) acoustic response of liquid-filled nanocapsules. IEEE Trans Ultrason Ferroelectr Freq Control 2014, 61, 5-15.

Janssen B, Vugts DJ, Funke U, Spaans A, Schuit RC, Kooijman E, Rongen M, Perk LR, Lammertsma AA, Windhorst AD. Syn-thesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflamma-tion. J. Labell. Cpnds & Radiopharm, 2014;57: 509-516.

Janssen B, Vugts DJ, Funke U, Spaans A, Schuit RC, Kooijman E, Rongen M, Perk LR, Lammertsma AA, Windhorst AD. Syn-thesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflam-mation. J Lab Comp Radiopharm. 2014 Jun 30;57(8):509-16.

Lainé AL, Gravier J, Henry M, Sancey L, Béjaud J, Pancani E, Wiber M, Texier I, Coll JL, Benoit JP, Passirani C. Conventional versus stealth lipid nanoparticles: Formulation and in vivo fate prediction through FRET monitoring. J Control Release. 2014, 188:1-8.

8

imaging life

publications 06/2014 – 08/2014

Mezzanotte L, Blankevoort V, Löwik CW, Kaijzel EL. A novel luciferase fusion protein for highly sensitive optical imaging: from single-cell analysis to in vivo whole-body bioluminescence imaging. Anal Bioanal Chem 2014 June

Mu L, Slavik R, Müller A, Popaj K, Cermak S, Weber M, Schibli R, Krämer SD, Ametamey SM. Synthesis and preliminary evaluation of a 2-oxoquinoline carboxylic acid derivative for PET imaging the cannabinoid type 2 receptor. Pharmaceu-ticals. 2014, 7, 339-52.

Patra M, Bauman A, Mari C, Fischer C A, Blacque O, Häussinger D, Gasser G, Mindt T L. An octadentate bifunctional che-lating agent for the development of stable zirconium-89 based molecular imaging probes. Chemical Communications August 2014.

Paul G, Prado Y, Dia N, Rivière E, Laurent S, Roch M, Elst LV, Muller RN, Sancey L, Perriat P, Tillement O, Mallah T, Catala L. Mn(II)-containing coordination nanoparticles as highly efficient T(1) contrast agents for magnetic resonance imaging. Chem Commun (Camb). 2014, 50(51):6740-3.

Pissarek M. Neuropeptide receptors in pain circuitries: useful targets for CNS imaging with non-peptide ligands suitable for PET? World J. Neuroscience, 2014, 4, 353-383

Pniok M, Kub icek V, Havlickova J , Kotek J, Sabatie-Gogov a A, Plutnar J, Huclier-Markai S, Hermann P. Thermodynamic and kinetic study of scandium(III) complexes of DTPA and DOTA: A step toward scandium radiopharmaceuticals. Chem. Eur. J. 2014 June 23, 20, 7944–7955.

Prost M, Canaple L, Samarut J, Hasserodt J. Tagging Live Cells that Express Specific Peptidase Activity with Solid-State Fluorescence. ChemBioChem 2014 Jul 7, 15, 1413–1417.

Rizzitelli S, Giustetto P, Boffa C, Delli Castelli D, Cutrin JC, Aime S, Terreno E. In vivo MRI visualization of release from lipo-somes triggered by local application of pulsed low-intensity non-focused ultrasound. Nanomedicine 2014, 10, 901-904

Rood MT, Oikonomou M, Buckle T, Raspe M, Urano Y, Jalink K, Velders AH, van Leeuwen FW. An activatable, polarity de-pendent, dual-luminescent imaging agent with a long luminescence lifetime. Chemical Communications 2014, 50, 9733-9736.

Rose HM, Witte C, Rossella F, Klippel S, Freund C, Schröder L .Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations. Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11697-702.

Rüger R, Tansi FL, Rabenhold M, Steiniger F, Kontermann RE, Fahr A, Hilger I. In vivo near-infrared fluorescence imaging of FAP-expressing tumors with activatable FAP-targeted, single-chain Fv-immunoliposomes. Journal of Controlled Release 2014, 186, 1-10

Sancey L & Gravier J, Hirsjärvi S, Rustique E, Passirani C, Benoît JP, Coll JL, Texier I. FRET Imaging Approaches for in Vitro and in Vivo Characterization of Synthetic Lipid Nanoparticles. Mol Pharm. 2014 Sep 2;11(9):3133-44.

Sanino A, Dastrú W, Mainini F, Delli Castelli D, Aime S, Terreno E. Polymeric vesicles loaded with gadoteridol as reversible and concentration-independent magnetic resonance imaging thermometers. J Biomed Nanotechnol. 2014, 10, 1620-1626.

Slavik R, Bieri D, Cermak S, Müller A, Krämer SD, Weber M, Schibli R, Ametamey SM, Mu L. Development and evaluation of novel PET tracers for imaging cannabinoid receptor type 2 in brain. Chimia. 2014, 68, 208-210.

probe development related papers

9

imaging life

publications 06/2014 – 08/2014

probe development related papersSoenen SJ, Manshian BB, Aubert T, Himmelreich U, Demeester J, De Smedt SC, Hens Z, Braeckmans K. Cytotoxicity of cadmium-free quantum dots and their use in cell bioimaging. Chem. Res. Toxicol. 2014 June; 27(6): 1050-1059.

Soenen SJ, Manshian BB, Himmelreich U, Demeester J, Braeckmans K, De Smedt SC. The performance of gradient alloy quantum dots in cell labeling. Biomaterials 2014 August;35(26): 7249-7258.

Soulie M, Latzko F, Bourrier E, Placide V,Butler SJ, Pal R, Walton JW, Baldeck PL, Le Guennic B, Andraud C, Zwier JM, La-marque L, Parker D, Maury O. Comparative analysis of conjugated alkynyl chromophore-triazacyclononane ligands for sensitized emission of europium and terbium. Chemistry-Eur-J. 2014, 20, 8636-8646

technology methodologyrelated papers

Alieva M, Ritsma L, Giedt RJ, Weissleder R, van Rheenen J. Imaging windows for long-term intravital imaging: general overview and technical insights. IntraVital 2014, 3

Bailey DL, Barthel H, Beuthin-Baumann B, Beyer T, Bisdas S, Boellaard R, Czernin J, Drzezga A, Ernemann U, Franzius C, Gückel B, Handgretinger R, Hartenbach M, Hellwig D, Helen Nadel H, Nekolla SG, Pfluger T, Pichler BJ, Quick HH, Sabri O, Sattler B, Schäfer J, Schick F, Siegel BA, Schlemmer HP, Schwenzer NF, van den Hoff J, Veit-Haibach P, Wehrl HF. Combined PET/MR. Where are we now? Summary Report of the Second International Workshop on PET/MR Imaging April 8-12, 2013, Tubingen, Mol Imaging Biol. 2014;16(3):295-310.

Boellaard R, Hofman MBM, Hoekstra OS, Lammertsma AA. Accurate PET/MR quantification using time of flight MLAA image reconstruction. Mol Imaging Biol. 2014 Aug;16(4):469-77.

Bouhlel N, Coron A, Barrois G, Lucidarme O, Bridal SL, Dual-mode registration of dynamic contrast-enhanced ultrasound combining tissue and contrast sequences Ultrasonics, 2014, 54, 1289-1299.

Bretin F, Mauxion T, Warnock G, Bahri M-A, Libert L, Lemaire C, Luxen A, Bardiès M, Seret A et Plenevaux A. Hybrid mi-croPET imaging for dosimetric applications in mice: Improvement of activity quantification in dynamic microPET imag-ing for accelerated dosimetry applied to 6-[18F]fluoro-L-DOPA and 2-[18F]fluoro-L-Tyrosine. Mol Imaging Biology 2014 Jun; 16(3):383-94.

Cao L, Bugalho R, Ferreira CS, Ortigão C, Capote RM, Varela J, Peter J. A Fast List-Mode Reconstruction Algorithm with Dedicated Correction for Random Coincidences for the Clear-PEM System. IEEE Transactions on Nuclear Science 2014 June, 61(3), 1182-1191

10

imaging life

publications 06/2014 – 08/2014

Dean-Ben XL, Buehler A, Razansky D, Ntziachristos V. Estimation of optoacoustic contrast agent concentration with self-calibration blind logarithmic unmixing. Physics in Medicine and Biology 2014, 59(17); 4785-4797

Deán-Ben XL, Ntziachristos V, Razansky D. Effects of small variations of speed of sound in optoacoustic tomographic im-aging. Med Phys. 2014, 41(7):073301.

ElAyouti A, Hülber-J M, Judenhofer MS, Connert T, Mannheim JG, Löst C, Pichler BJ, von Ohle C. Apical constriction: loca-tion and dimensions in molars-a micro-computed tomography study. J Endod. 2014;40(8):1095-9.

Eyer K, Herger M, Krämer SD, Dittrich PS. Cell-free microfluidic determination of P-glycoprotein interactions with sub-strates and inhibitors. Pharm Res. 2014 Jun 14.

Kolb A, Parl C, Mantlik F, Liu CC, Lorenz E, Renker D, Pichler BJ. Development of a novel depth of interaction PET detector using highly multiplexed G-APD cross-strip encoding. Med Phys. 2014;41(8):081916.

Mohajerani P, Kellnberger S, Ntziachristos V. Frequency Domain Optoacoustic Tomography using Amplitude and Phase. Photoacoustics 2014, 2(3); 111-118

Nieuwstadt HA, Geraedts TR, Truijman MT, Kooi ME, van der Lugt A, van der Steen AF, Wentzel JJ, Breeuwer M, Gijsen FJ. Numerical simulations of carotid MRI quantify the accuracy in measuring atherosclerotic plaque components in vivo. Magn Reson Med. 2014, 72, 188-201.

Omar M, Soliman D, Gateau J, Ntziachristos V. Ultrawideband reflection-mode optoacoustic mesoscopy. Opt Lett. 2014, 39(13):3911-4.

Raijmakers P, Temmerman OPP, Saridin CP, Heyligers IC, Becking AG, van Lingen A, Lammertsma AA. Quantification of 18F-fluoride kinetics: evaluation of simplified methods. J Nucl Med. 2014;55(7):1122-7.

Roosenburg S, Laverman P, Joosten L, Cooper MS, Kolenc-Peitl PK, Foster JM, Hudson C, Leyton J, Burnet J, Oyen WJ, Blower PJ, Mather SJ, Boerman OC, Sosabowski JK. PET and SPECT Imaging of a Radiolabeled Minigastrin Analogue Conjugated with DOTA, NOTA, and NODAGA and Labeled with 64Cu, 68Ga, and 111In. Mol Pharm. 2014, Jul 11. [Epub ahead of print]

Sancey L & Motto-Ros V, Busser B, Kotb S, Benoit JM, Piednoir A, Lux F, Tillement O, Panczer G, Yu J. Laser spectrometry for scanning elemental imaging of biological tissues. Sc. Reports 2014 4,

Sancey L, Motto-Ros V, Kotb S, Lux F, Panczer G, Yu J, Tillement O. Laser-Induced Breakdown Spectroscopy: A New Ap-proach For Nanoparticle‘s Mapping And Quantification In Organ Tissue. J. Vis. Exp. 2014 (88),

Schmidt H, Schwenzer NF, Bezrukov I, Mantlik F, Kolb A, Kupferschläger J, Pichler BJ. On the Quantification Accuracy, Homo-geneity, and Stability of Simultaneous Positron Emission Tomography/Magnetic Resonance Imaging Systems. Invest Radiol. 2014;49(6):373-81

Smith D, Artursson P, Avdeef A, Di L, Ecker GF, Faller B, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, van de Waterbeemd H, Sugano K, Testa B. Passive lipoidal diffusion and carrier-mediated cell uptake are both important mecha-nisms of membrane permeation in drug disposition. Mol Pharm. 2014,11,1727-38.

Symvoulidis P, Jentoft KM, Garcia-Allende PB, Glatz J, Ripoll J, Ntziachristos V. Steady-state total diffuse reflectance with an exponential decaying source Opt Lett. 2014, 39(13):3919-22.

Vaquero J, Montesinos P, Cussó L, García-Vazquez V, Desco M. In-line high resolution PET and 3T MRI hybrid device for preclinical multimodal imaging. EJNMMI Physics 2014, 1 (Suppl 1):A7.

technology/methodology related papers

11

imaging life

publications 06/2014 – 08/2014

technology/methodology related papersvan de Watering FC, Rijpkema M, Perk L, Brinkmann U, Oyen WJ, Boerman OC. Zirconium-89 labeled antibodies: a new tool for molecular imaging in cancer patients. Biomed Res Int. 2014;2014:203601.

Veres IA, Burgholzer P, Berer T, Rosenthal A, Wissmeyer G, Ntziachristos V. Characterization of the spatio-temporal re-sponse of optical fiber sensors to incident spherical waves. J. Acoust. Soc. Am. 2014, 135; 1853-1862

Wimberley C, Angelis G, Boisson F, Callaghan P, Fischer K, Pichler B, Meikle SR, Grégoire MC, Reilhac A. Simulation-based optimisation of the PET data processing for Partial Saturation Approach protocols. Neuroimage. 2014;97:29-40.

Wolbank S, Pichler V, Ferguson JC, Meinl A, van Griensven M, Goppelt A, Redl H. Non-invasive in vivo tracking of fibrin degradation by fluorescence imaging. J Tissue Eng Regen Med 2014, Jul 6

Abstract deadline29 October 2014

Abstract deadline9 December 2014

www.topim.eu

www.emim.eu

IMAGING INFLAMMATION 1-6 Feb. 2015

18-20 MARCH in Tübingen, Germany

Abstract topicsAuto Immunity

Cancer Immune Cell Therapy

Immunity & Inflammation

Immune-Cell Response

Micro-Bio Immunity

Neuro-Inflammation

Organ Transplantation

Others

Speakers so far:

Eric T. Ahrens - San Diego, Daniel R. Engel - Essen, Carl Figdor - Nijmegen, Daniel Kreisel - St. Louis, Paul Kubes - Calgary, Eicke Latz - Bonn, Steffen

Massberg - Munich, Marco Prinz - Freiburg, Denis Vivien - Caen

Les Houches, FR

abstract topicsCardiologyNeurologyOncology

Infectious DiseaseImmunology/Inflammation

Imaging Technology, Methodology & SoftwareImaging Probes, Chemistry, Reporter Genes

Others

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