The Microbiome: Programming the Future from the Inside Out

Dr. Tiffany VoraDecember 7, 2016

We are more than humanIm

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Our microbiome is critical

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David et al., Genome Biology 2014

… and dynamic

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David et al., Genome Biology 2014

We need our microbiome Im

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Immune System

Microbes tune our behavior

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How do I impact my microbiome?

Microbiome Survivor: round 1

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Microbiome Survivor: round 2

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Microbiome Survivor: round 3

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Microbiome Survivor: round 4

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Microbiome Survivor: round 5

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Triclosan

Microbiome Survivor: round 6

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How do I explore my microbiome?

The skin microbiome

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My cat

My son

What Lives on You?

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Selfies

Walkies

Sequence your microbiome

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uBiome results: diversity

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uBiome results: diversity

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More “Western” diet, less exercise

uBiome results: diversity

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What can I do?

1. How do I change me?

2. How do I drive larger change?

What is the future of the microbiome?

Curing disease

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Based on van Nood et al., NJEM 368;5 (2013)

Resetting dysbiosis: Seres Therapeutics

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Resetting dysbiosis: Seres Therapeutics

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DIY fecal transplants

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DIY fecal transplants

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What can we achieve?

Smart toilets

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Tuning body weight

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The spectrum of malnutrition

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Adult malnutrition in 2016

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2 in 5 adults areoverweight or obese

2 in 12 adults havetype 2 diabetes

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667 million children <5 years old

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Images courtesy of ShutterstockData from the 2016 Global Nutrition Report

159 million children are stunted

50 million children are wasted

41 million children are overweight

Early nutrition critically impacts life

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The burden of malnutrition

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2016 Global Nutrition Report:Stunting, WastingOverweightAdult obesity/overweight

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9.4%, 2.3%6.6%34.4%

1.4 billion people

38.7%, 15.1%1.9%

22.0%

1.25 billion people

2.1%, 0.5%6.0%67.3%

321 million people

Further reading

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Further reading

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Thank you!Dr. Tiffany VoraPrincipal Faculty, Digital Biology & Medicinetiffany.vora@singularityu.org

Further exploration

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● Sonnenburg J and Sonnenburg E. The Good Gut: Taking Control of Your Weight, Your Mood, and Your Long-term Health. 2015. Penguin Random House.

● Yong E. I Contain Multitudes: The Microbes Within Us and a Grander View of Life. 2016. HarperCollins Publishers..

● David LA, Materna AC, et al. Host lifestyle affects human microbiota on daily timescales. Genome Biology (2014), 15: R89. doi: 10.1186/gb-2014-15-7-r89

● uBiome’s Gut Explorer (non-clinical)● van Nood E, Vrieze A, et al. Duodenal Infusion of Donor Feces for Recurrent

Clostridium difficile. New England Journal of Medicine (2013), 368: 407-415. doi: 10.1056/NEJMoa1205037

● The 2016 Global Nutrition Report, from the International Food Policy Research Institute

● Scientific American’s Microbes in the Gut are Essential to Our Wellbeing● New York Magazine’s Eating with a Microbiome Researcher● An 8-year-old’s handprint on MicrobeWorld and Upworthy

Keep an eye on ….

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● Your own health● Reputable news outlets

○ Wired○ The Scientist○ The New York Times

● Collaborations between nutrition and pharmaceuticals● Beyond the gut

○ Skin○ Birth○ Architecture

uBiome: welcome

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uBiome results: take action

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uBiome results: genera

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Drug discovery: Second Genome

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Drug discovery: Vedanta Biosciences

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