General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-mail: symposia@falkfoundation.dewww.falkfoundation.de

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Program

Falk Symposium 189

Eosinophilic Esophagitis:A Novel Chronic-Infl ammatoryDisease of the GI Tract

September 6 – 7, 2013Congress GrazGraz, Austria

CME credits 11

Awarded with

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Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 10

List of Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . 13

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

11 credit hours (CME) have been awarded for the Falk Workshop by the European Union of Medical Specialists (UEMS) – European Board of Gastroenterology (EBG) .

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Preface

As a head of the organizing committee, I am pleased to invite you all to the Falk Symposium 189 “Eosinophilic Esophagitis: A novel chronic-inflammatory disease of the gastrointestinal tract” that will take place in the city of Graz, Austria .

Eosinophilic esophagitis (EoE) was first recognized as a distinct entity in 1993 . In 2013, we will mark the 20th anniversary of EoE discovery . Whether a 20-year period can be considered a long time very much depends on one’s perspective . For EoE patients suffering from swallowing difficulties, 20 years is certainly a long time . In contrast, for researchers studying EoE, 20 years is a relatively short time . Twenty years of learning about EoE made us realize that for every question that is answered many more questions still remain unanswered or not even thought of yet .

The past two decades had a profound impact on EoE . Today, EoE has become a regularly-diagnosed disease, and is likely to be the leading cause of dysphagia . Fortunately, a number of milestone discoveries have deepened our understanding of the genetic and immunological mechanisms of EoE and led to improved therapeutic modalities . Unfortunately, permanent treatment options still remain elusive today .

This symposium brings together many world-renowned EoE experts, from pioneers, who led early work on EoE, to a new generation of investigators that will continue to shape the future of EoE research . Attendees of this meeting will have the unique opportunity to meet key opinion leaders from several disciplines, such as allergy, pathology, immunology, adult and pediatric gastroenterology . The program is designed to bridge the gap between basic science and daily clinical practice . Falk Foundation lends its generous support to organization of what I hope will be one extraordinary meeting on the occasion of 20th anniversary of EoE discovery .

Speaking on behalf of the organizing committee, it is with great pleasure that I invite you to participate in this symposium and look forward to welcoming you in the wonderful city of Graz in September of 2013 .

Alex Straumann, Olten, Switzerland

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Falk Symposium 189

Eosinophilic Esophagitis:A Novel Chronic-Infl ammatory Disease of the GI Tract

Congress GrazGraz, Austria

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Registration:Thursday, September 5, 201308 .00 – 21 .00 hat the congress offi ce

Scientifi c Organization:A . Straumann, Olten (Switzerland)A . Schoepfer, Lausanne (Switzerland)H .-U . Simon, Bern (Switzerland)

Congress Venue:Congress GrazSparkassenplatz 38010 GrazAustria

Information:Prof . Dr . Alex StraumannChairman Swiss EoE Research GroupRömerstr . 74600 OltenSwitzerlandTelephone: + 41(0)62/2125577Telefax: + 41(0)62/2125564E-Mail: alex .straumann@hin .ch Offi cial Language:English . Simultaneous translation into German .

Posters:For details see page 10

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Friday, September 6, 2013

8.15 Welcome A . Straumann, Olten

Session I BASICS I: The eosinophil and the GI Tract

Chair: G . T . Furuta, Aurora; D . Simon, Bern

8.20 Structural and functional barriers of the GI Tract M . Vieth, Bayreuth

8.40 Immunoregulatory role of eosinophils P . Valent, Vienna

9.00 Effector functions of eosinophils and immunopathology H .-U . Simon, Bern

9.20 Fibrosis and remodeling in chronic eosinophil S . Aceves, inflammation San Diego

9.40 Panel discussion

10.00 Coffee break with poster session

Session II BASICS II: Genetic-environmental interactions

Chair: S . Aceves, San Diego; H .-U . Simon, Bern

10.30 Genetic abnormalities in EoE C . Blanchard, Lausanne

10.50 EoE and allergy D . Simon, Bern

11.15 Has elimination of exogenous allergens the potential N . Gonsalves, to cure EoE? Chicago

11.40 Panel discussion

12.00 Lunch break with poster session

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Friday, September 6, 2013

Session III HISTOLOGY and EPIDEMIOLOGY: EoE a new or simply a newly recognized disease?

Chair: N . Gonsalves, Chicago; A . Straumann, Olten

13.30 EoE’s view through the retro-spectoscope: S . Attwood, From case report to clinical trials North Shields

13.50 Epidemiology (incidence and prevalence) of pediatric P . Hruz, and adult EoE Basel

14.10 Diagnostics of EoE: Clinical, endoscopical and E . S . Dellon, histological pitfalls Chapel Hill

14.30 EoE: Asthma of the esophagus J . C . Virchow, Rostock

14.50 Panel Discussion

15.10 Coffee break with poster session

Session IV EOSINOPHILIC ESOPHAGITIS: A clinico-pathological disease?

Chair: S . Attwood, North Shields; C . Bussmann, Basel

15.40 Clinical features of eosinophilic esohagitis S . Miehlke, Hamburg

16.00 Histopathology of eosinophilic esophagitis M . H . Collins, Cincinnati

16.20 Requirements of the pathologist to the endoscopist C . Bussmann, (biopsy sampling) Basel

16.40 Value of advanced diagnostics (endo, pH/impedance, I . Hirano, manometry, EndoFlip) Chicago

17.00 Value of allergy tests B . Ballmer-Weber, Zurich

17.20 Panel Discussion

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Saturday, September 7, 2013

Session V EoE-PHENOTYPES and ASSESSMENT of DISEASE ACTIVITY

Chair: I . Hirano, Chicago; S . J . Spechler, Dallas

8.00 EoE in kids and in adults: One single entity or two N . Gonsalves, different diseases? Chicago

8.20 Complex relationship between EoE and GERD D . Katzka, Rochester

8.40 Requirements to activity assessment instruments Y . Romero, (principles) Rochester

9.00 Determination of EoE’s activity A . Schoepfer, Lausanne

9.20 Non- and semi- invasive methods to monitor EoE G . T . Furuta, Aurora

9.40 Perspective and requirements from the regulatory A . E . Mulberg, authorities Silver Spring

10.00 Coffee break with poster session

Session VI TREATMENT I: Current therapeutic options (The DDD’s)

Chair: D . Katzka, Rochester; S . Miehlke, Hamburg

10.30 Indications for therapy (natural history) A . Straumann, Olten

10.50 Treatment of EoE in children A . Kagalwalla, Chicago

11.10 Treatment of adult EoE with diet A . J . Lucendo, Tomelloso

11.30 Treatment of EoE with drugs 1: Corticosteroids U . von Armin, Magdeburg

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Saturday, September 7, 2013

11.50 Treatment of EoE with drugs 2: H .-U . Simon, Non-corticosteroid drugs Bern

12.10 Treatment of EoE with dilation A . Schoepfer, Lausanne

12.30 Presentation of poster prizes A . Schoepfer, Lausanne

12.40 Lunch break with poster session

Session VII TREATMENT II: Current therapeutic concepts future options

Chair: A . J . Lucendo, Tomelloso; Y . Romero, Rochester

13.30 Therapeutic concept 2013 (summary) I . Hirano, Chicago

13.50 Management of refractory EoE G . T . Furuta, Aurora

14.10 Future therapeutic options A . Straumann, Olten

14.30 Unmet diagnostic needs D . Katzka, Rochester

14.50 Unmet therapeutic needs S . Aceves, San Diego

15.10 WRAP-UP A . Straumann, Olten

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Poster SessionPosters will be exhibited on September 6 - 7, 2013, at the „Congress Graz”, Graz . The authors will be in attendance during coffee and lunch breaks on both days .

1 . Comparison of demographic and endoscopic features with pH metric findings in patients with gastroesophageal reflux symptoms Z . Akpinar, E . Saritas Yuksel, S . Vatansever, F . Topal, F . Aslan, H . Sinan Akay, A . Alpay Alparslan, B . Unsal (Izmir, TR)

2 . Effect of four food elimination diet on clinical and histologic outcomes in eosinophilic esophagitis K . Amsden, S . Schwartz, M . Chehade, M . Manuel-Rubio, H . Melin-Aldana, O . Yershov, M . Groetch, J . Wechsler, B .K . Wershil, A .F . Kagalwalla (Chicago, New York, US)

3 . A novel minimally invasive esophageal string test measures changes in mucosal inflammation in pediatric eosinophilic esophagitis during treatment K . Amsden, A .F . Kagalwalla, P . Alumkal, S . Ochkur, J .J . Lee, G .T . Furuta, S . Ackerman (Chicago, Scottsdale, Aurora, US)

4 . Dietary treatment effects in expression mast cell genes in esophagus and duodenum in EoE adult patient A . Arias, P . Martinez-Fernández, A .J . Lucendo (Alcazar de San Juan, Madrid, Tomelloso, ES)

5 . TLRs expression in eosinophilic esophagitis and changes after dietary treatment A . Arias, P . Martinez-Fernández, A .J . Lucendo (Alcazar de San Juan, Madrid, Tomelloso, Ciudad Real, ES)

6 . The absence of eosinophilic esophagitis in a large cohort of patients with gastro-esophageal reflux disease in Turkey S . Bor, R . Vardar, B . Doganavsargil (Izmir, TR)

7 . Prevalence, clinical manifestations and endoscopic features of eosinophilic esophagitis C . Deliu, E .F . Georgescu, D . Citu, R . Teodorescu, M . Bezna (Craiova, RO)

8 . Prevalence of eosinophilic esophagitis in children: Clinical manifestations and endoscopic findings C . Deliu, E .F . Georgescu, D . Citu, R . Teodorescu, M . Bezna (Craiova, RO)

9 . An 4-year follow-up of patients with eosinophilic esophagitis C . Deliu, E .F . Georgescu, R . Teodorescu, M . Bezna (Craiova, RO)

10 . Radiofrequency ablation in patients with diseases of GIT J . Gregar, V . Prochazka, M . Konecny, P . Luzna, J . Ehrmann, Jr . (Olomouc, CZ)

11 . Prediction of NBI endoscopy in diagnosis of dysplastic changes in patients with Barrett‘s esophagus J . Gregar, P . Luzna, V . Prochazka, J . Ehrmann, Jr . (Olomouc, CZ)

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12 . The important side effects of long-term medical treatment of gastroesophageal reflux disease M . Jecmenova, R . Kroupa, J . Dolina, J . Prokesova, A . Hep (Brno, CZ)

13 . The association between gastroesophageal flap valve function and gastroeso-phageal reflux symptoms, endoscopic features, Helicobacter pylori status and body mass index O . Keskin, A . Tüzün, A . Yaman, H . Cetinkaya, I . Soykan (Ankara, TR)

14 . Quality of life of patients with gastroesophageal reflux disease (GERD) in Poland M . Korzonek, A . Dziergas, M . Kuczynska (Szczecin, PL)

15 . Different clinical manifestation of eosinophilic esophagitis - Case series R . Kroupa, M . Jecmenova, J . Prokesova, J . Dolina, A . Hep (Brno, CZ)

16 . Eosinophilic esophagitis in children with coexistent celiac disease J .M . Lotowska, M .E . Sobaniec-Lotowska, L . Kanczuga-Koda, S .B . Bockowska, G .A . Korakiewicz, E . Jarocka-Cyrta (Bialystok, PL)

17 . The correlation of nutritive status, body composition and symptoms in patients with gastroesophageal reflux disease T . Lukic, N . Milinic, G . Nikolic, B . Filipovic, M . Cvetkovic, I . Jovanovic, O . Rnjakovic, J . El-Kiswani (Belgrade, RS)

18 . Eosinophilic enteritis (EE) with ascites triggered after childbirth: An exceptional form of presentation J . Millastre Bocos, E . Bajador Andreu, S . Garcia Lopez, A . Mir Subias, T . Marcuello Peña (Zaragoza, ES)

19 . Prevalence, clinical presentation and endoscopic findings of eosinophilic esophagitis in adult patients in a south-west region of Romania P . Mitrut, A .O . Docea, A . Genunche-Dumitrescu, R . Mitrut, D . Badea, S . Zavaleanu (Craiova, RO)

20 . Treatment with proton-pump inhibitors and budenoside is effective in adult patients with eosinophilic esophagitis P . Mitrut, A .O . Docea, R . Mitrut, A . Genunche-Dumitrescu, D . Badea, S . Zavaleanu (Craiova, RO)

21 . Long-term efficacy of proton-pump inhibitor therapy in patients with PPI-responsive esophageal eosinophilia J . Molina-Infante, C . Martinez-Alcala, D . Vara-Brenes, R . Prados-Manzano, D . Katzka (Caceres, ES; Rochester, US)

22 . An optimized four-food elimination diet (dairy, gluten, egg and legumes) might be as effective as six-food elimination diet for adult eosinophilic esophagitis: Preliminary results J . Molina-Infante, J . Rodriguez-Sanchez, A . Arias-Arias, M . Sanchez-Cazalilla, J . Barrio, A .J . Lucendo (Caceres, Valdepeñas, Ciudad Real, Madrid, Valladolid, Tomelloso, ES)

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23 . Proton-pump inhibitor-responsive esophageal eosinophilia correlates with down-regulation of eotaxin-3 and Th2 cytokines overexpression J . Molina-Infante, M .D . Rivas, G . Vinagre-Rodriguez, M . Hernandez-Alonso, J .M . Mateos-Rodriguez, C . Dueñas-Sadornil, B . Perez-Gallardo, R . Bañares, J . Zamorano (Caceres, Madrid, ES)

24 . Safety of propofol administration in adult eosinophilic esophagitis patients sensitized to egg, soy or peanut J . Molina-Infante, A . Arias-Arias, D . Vara-Brenes, R . Prados-Manzano, A .J . Lucendo (Caceres, Ciudad Real, Tomelloso, ES)

25 . Clinical manifestation and epidemiology of pediatric eosinophilic esophagitis in Switzerland: A population-based approach P . Müller, E . Safroneeva, A . Straumann (St . Gallen, Bern, Olten, CH)

26 . Gastroesophageal reflux disease and Helicobacter pylori: Interplay or simply independent? S . Parlog, G . Parlog, (Bucarest, Bacau, RO)

27 . Elsa score - A new tool to evaluate the symptoms in adults with eosinophilic esophagitis J . Rodriguez-Sánchez, E . Gómez Torrijos, E . de la Santa Belda, F . Martin Dávila, J . Olmedo Camacho, P . Reales Figueroa (Valdepeñas, Ciudad Real, ES)

28 . Remision of eosinophilic esophagitis with an exclusion diet of less than 4 foods: Is this possible? J . Rodriguez-Sánchez, E . Gómez Torrijos, E . de la Santa Belda, F . Martin Dávila, P . Pilkington Woll, J . Olmedo Camacho, P . Reales Figueroa (Valdepeñas, Ciudad Real, ES)

29 . Eosinophilic esophagitis: A descriptive study of a series of 35 cases M . San Juan Acosta, M . Rodriguez Téllez, A . Flores, M . Mora Cabezas, A . Garcia Escudero, C . Lizarralde, A . Caunedo Alvarez, J .M . Herrerias Gutiérrez (Madrid, Seville, ES)

30 . Quality of life in eosinophilic esophagitis: Validation of the adult eosinophilic esophagitis quality of life (EoE-QoL-A) questionnaire in Spain M . Sánchez-Cazalilla, A .J . Lucendo, J .M . Tenias, J . Molina-Infante, C . Ciriza de los Rios, I . Pérez-Martinez (Madrid, Tomelloso, Alcázar de San Juan, Caceres, Oviedo, ES)

31 . Evaluation of eosinophil cationic protein and mast cell tryptase as serum markers for treatment control in eosinophlilic esophagitis C . Schlag, S . Pfefferkorn, K . Brockow, S . Schulz, B . Haller, J . Slotta-Huspenia, A . von Werder, J . Ring, R .M . Schmid, M . Bajbouj (Munich, DE)

32 . Eosinophilic esophagitis in pediatric patients - Histophathological analysis M .E . Sobaniec-Lotowska, J .M . Lotowska, E . Jarocka-Cyrta, A . Wincewicz, S .B . Bockowska (Bialystok, Kielce, PL)

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List of Speakers, Moderators and Scientific Organizers

Seema Aceves, M.D., Ph.D.University of CaliforniaRady Children‘s Hospital3020 Children‘s WaySan Diego CA 92123USAsaceves@ucsd .edu

Dr. Ulrike von ArnimGastroenterologie/HepatologieUniversitätsklinikumOtto-von-Guericke-UniversitätLeipziger Str . 4439120 MagdeburgGermanyulrike .vonarnim@med .ovgu .de

Prof. Dr. Stephen AttwoodNorth Tyneside General HospitalRake LaneNorth Shields NE29Great Britainstephen .attwood@northumbria-healthcare .nhs .uk

Prof. Dr. Barbara Ballmer-WeberUniversitätsspital ZürichDermatologische KlinikAllergiestation/EpikutanlaborGloriastr . 318091 ZürichSwitzerlandbarbara .ballmer@usz .ch

Dr. Carine BlanchardNestlé Research CenterNutrition and HealthAllergy GroupPO Box 441000 LausanneSwitzerlandcarinegaelle .blanchard@rdls .nestle .com

Dr. Christian BussmannViollier AGInstitut für PathologieJacob Burckhardstr . 864002 BaselSwitzerlandchristian .bussmann@violier .ch

Margaret H. Collins, M.D.Cincinnati Children‘s HospitalMedical CenterDivision of Pathology3333 Burnet AvenueCincinnati OH 45229-3039USAmargaret .collins@cchmc .org

Evan S. Dellon, M.D.University of North CarolinaGastroenterology & HepatologyBioinformatic Bldg .130 Mason Farm RoadChapel Hill NC 27599-7080USAedellon@med .unc .edu

Glenn T. Furuta, M.D.The Children‘s HospitalGastroenterology, Hepatology& Nutrition, B29013123 East 16th AvenueAurora CO 80045USAfuruta .glenn@tchden .org

Nirmala Gonsalves, M.D.Northwestern UniversityArkes Familiy Pavilion Suite 140676 North St . Clair StreetChicago IL 60611USAn-gonsalves@northwestern .edu

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Ikuo Hirano, M.D.Professor of MedicineNorthwestern University School of Medicine676 North Saint Clair Street, Suite 1400Chicago IL 60611-2951USAi-hirano@northwestern .edu

Dr. Petr HruzKantonsspitalGastroenterologie & HepatologiePetersgraben 44031 BaselSwitzerlandhruzp@uhbs .ch

Amir Kagalwalla, M.D.Feinberg School of Medicine Northwestern UniversityDivision of GastroenterologyHepatology and NutritionLurie Children‘s Hospital 225 East Chicago AvenueChicago IL 60611-2605USAakagalwalla@luriechildrens .org

David Katzka, M.D.Mayo ClinicDivision of Gastroenterologyand Hepatology200 First Street SWRochester MN 55905USAkatzka .david@mayo .edu

Dr. Alfredo J. LucendoHospital General de TomellosoDepartment of GastroenterologyVereda de Socuéllamos, n/n13700 TomellosoSpainajlucendo@hotmail .com

Prof. Dr. Stephan MiehlkeMagen-Darm-ZentrumIntern . Kooperation EppendorfEppendorfer Landstraße 4220249 HamburgGermanyprof .miehlke@mdz-hamburg .de

Andrew E. Mulberg, M.D.Center for Drug Evaluationand ResearchDivision of Gastroenterology& Inborn Error Products10903 New Hampshire Ave .Silver Spring MD 20993USAandrew .mulberg@fda .hhs .gov

Yvonne Romero, M.D.Mayo ClinicDepartment of Gastroenterologyand Hepatology200 First Street SWRochester MN 55905USAromero .yvonne@mayo .edu

Dr. Alain SchoepferDepartment of GastroenterologyUniversitätsklinik LausanneCHUV1011 LausanneSwitzerlandalain .schoepfer@chuv .ch

Prof. Dr. Dagmar SimonUniversität Bern, InselspitalKlinik für Dermatologie3010 BernSwitzerlanddagmar .simon@sec .insel .ch

Prof. Dr. Dr. Hans-Uwe SimonUniversität BernInstitut für PharmakologieFriedbühlstr . 493010 BernSwitzerlandhus@pki .unibe .ch

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Stuart J. Spechler, M.D.Professor of MedicineVA Medical CenterDepartment of Gastroenterology4500 S . Lancaster RoadDallas TX 75216-7167USAsjspechler@aol .com

Prof. Dr. Alex StraumannFMH GastroenterologieRömerstr . 74600 OltenSwitzerlandalex .straumann@hin .ch

Prof. Dr. Peter ValentMedizinische Universität WienAbteilung für Hämatologieund HämostaseologieWähringer Gürtel 18-201090 WienAustriapeter .valent@meduniwien .ac .at

PD Dr. Michael ViethPathologieKlinikum BayreuthPreuschwitzer Str . 10195445 BayreuthGermanyvieth .lkpathol@uni-bayreuth .de

Prof. Dr. J. Christian VirchowPneumologieKlinikum der Universität RostockErnst-Heydemann-Str . 618057 RostockGermanyj .c .virchow@med .uni-rostock .de

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Congress OfficeDuring Falk Symposium 189

Telephone: +49(0)175/7795327

Congress GrazSparkassenplatz 38010 GrazAustria

Opening Hours:Thursday, September 5, 2013 8 .00 – 21 .00 hFriday, September 6, 2013 7 .30 – 18 .00 hSaturday, September 7, 2013 7 .30 – 15 .30 h

Congress FeesScientific program of the Falk Symposium 189 e 200,–Students and residents e 100,–

* * * OR * * *

Day ticket e 120,–Students and residents e 60,–

Employees of pharmaceutical companies and their guestsFalk Symposium 189 e 600,-

The congress fees include:- Welcome Evening on September 5, 2013- Refreshments during coffee breaks- Lunch on September 6 and 7, 2013- A copy of the abstract volume

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Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible .

Congress ReportThe official congress report of the Falk Workshop „GERD: Gastroesophageal Reflux Disease“ and Falk Symposium 189 “Eosinophilic Esophagitis: A novel chronic- inflammatory disease of the GI Tract” will be published in English in the first half of 2014 by Karger, Switzerland . Orders for this book at a reduced subscription price of e 35,- can be placed at the Congress Office during the congress in Graz .

AirportAirport Graz

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General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DepartmentTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-mail: symposia@falkfoundation.dewww.falkfoundation.de

P 18

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Program

Falk Symposium 189

Eosinophilic Esophagitis:A Novel Chronic-Infl ammatoryDisease of the GI Tract

September 6 – 7, 2013Congress GrazGraz, Austria

CME credits 11

Awarded with

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