8/8/2019 Profile of Biopsy Proven Renal Disease at a Tertiary Care Center

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Profile of biopsy proven renal disease at a tertiary care centerJP Paul*, S Simon*, RS Manju**, B Francis*, S Pillai*, S Nambiar*

Department of Nephrology, Lisie Hospital, Cochin

*Department of Nephrology, ** Biostatistician

Abstract

Aim: To study the spectrum of biopsy proven renal disease (BPRD), from January 2004

to December 2008 (five years) and to compare the biopsy profile with otherpublished studies

Materials and Methods: Retrospective analysis of histopathological reports of all native

kidney biopsies conducted at Lisie Hospital from January 2003 to December 2008 ispresented (n=881). Incomplete records (n=34) and incomplete biopsies (n=11) were

excluded. The data from the remaining biopsies (n=836); 48 from children < 15 years and

788 from adults(15 years and above) were analyzed and categorized into majorhistopathological patterns as Diffuse proliferative glomerulonephritis(DPGN), Ig A

nephropathy(Ig A), Focal segmental glomerulosclerosis(FSGS), Membranous

glomerulonephritis(MGN), Mesangial proliferative glomerulonephritis(MesGN),Minimal change disease (MCD), Crescentic glomerulonephritis(Cresentic GN),acute

tubular necrosis (ATN), acute interstitial nephritis(AIN), diabetic

glomerulosclerosis(DG) ,Thrombotic microangiopathy(TMA) and benign arteriolarnephrosclerosis(BANS)

Statistical analysis was done using SPSS ver 15.0

Results: Commonest primary glomerular disease in adults was Ig A nephropathy (20.3%,n-160); while the commonest primary glomerular disease in children was MCD (39.9%),

followed by Ig A nephropathy (19.9%). ATN and AIN was the commonest cause of ARF

in adults, followed by DPGN; while DPGN was the commonest biopsy finding inchildren with ARF. The incidence of non diabetic renal disease in diabetic patients

(n=87) was 62.31%, commonest cause being DPGN followed by FSGS, Ig A

nephropathy and AIN. The commonest cause for nephrotic syndrome in adults was Ig Anephropathy (18.5%) followed by FSGS (14.7%).There was a male preponderance for all

diseases except for amyloidosis and lupus nephritis. Ig A nephropathy was the most

common primary glomerular disease in all the five years of the study. This was compared

with the Italian registry shows a similar incidence of Ig A, among the primary glomerulardisease while the incidence of MGN was higher in Italian registry data. Comparison with

CMC data shows a similar prevalence of PIGN and MCD while FSGS was reported as

the commonest primary glomerular disease in all age groups in the CMC study.

Conclusion: This study shows the descriptive statistical data regarding the prevalence of

various biopsy proven renal diseases in our geographical area.