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Prof.DR.Kuntaman,dr.,MS,SpMK(K)
• Advisor KPRA KEMENKES R.I
• Advisor KPRA RSUD Dr.Soetomo
• Ka.Prodi Magister/S2 Ilmu Kedokteran
Dasar FK UNAIR
• Ketua Dewan Etik FK UNAIR
• Ketua PAMKI Pusat
Surveilans of AMR (MDRO) in Indonesia
Kuntaman FK Universitas Airlangga/RSU Dr. Soetomo Surabaya
Komite Pengendalian Resistensi Antimikroba
Kementerian Kesehatan Republik Indonesia
[email protected], 08113410352
Pelatihan PPRA & SNARS, Surabaya, Jan,19-21, 2018
Problem Statement
• Surveillance: is the monitoring of the behavior, activities, or other changing information, usually of people for the purpose of influencing, managing, directing, or protecting them (Health Services)
• Focus AMR &/or AMU
• Indicator: ?? (should be determined): National
– Evidence based
– Sensitive to be monitored
– Higher impact in clinical setting Inf Dis
The Surveillance Steps
• Commitment
• Situation analysis
• Governance
• Mapping
• stakeholder involvement
• for developing/strengthening
the existing system (in every
ward/center)
IDSA Guidelines. Clin. Inf. Diseases Advance Access published July 10, 2013
The Surveillance Steps
• Funding and Priority
• Approach: Bottom-up & Top-down
• Effectivity and Efficiency
• Networking: Local, Regional, Global
• Minimal requirements of
participants/centers: Assessment
Global Antimicrobial
Resistance Surveillance
System
GLASS-2014
Bacterial Indicator AB
1. E coli SXT, QNs, C3rd,Carb,Col,AMX
2. K pneumoniae SXT, CIP, C3rd,Carb,Col,AMX
3. Acin baumannii AN, TGC, Carb, Col
4. Sta aureus FOX, MRSA?
5. Strep pneumo OXA, Pen, SXT, CRO/CTX
6. Salmonella spp QNs, C3rd, Carb
7. Shigella spp QNs,C3rd,Azithro
8. N gonorrhoeae FIX, CRO, Azithro
GLASS-2014
Specimen Bacteria
1. Blood E. coli; K. pneumoniae; A. Baumannii;
S. aureus
S. pneumoniae; Salmonella spp.
2. Urine E coli, K. pneu
3. Faeces Salm, Shigella
4. Urethra, Cx N go
Metric Measurement
Specimen Measurement = Indicator
1. Urine Num: Pathogen/s identified vs AST
Deno: Total Urine sample
Num: E coli & ESBL+
Deno: Total E coli
Num: E coli & Cip-Res
Deno: Total E coli
2. Blood Num: E coli in Spesis Pts
Deno: Total Population (per 100.000 Pop)
Indonesia Surveillance
on AMR/MDRO &/or AMU
(Antimicrobial Use)
MDRO: sangat banyak
• Surveillance:
–Semua: ??
–Indikator spesifik: ?? Apa: ??
–Murah & Manfaat ++
MDRO: Multiple Drug Resistant Organisms
• Resistance against minimally 3
Classes of Antibiotics
• Ex:
–Ceph, FQ, Amino
–FQ, TGC, MEM
–ERY, DA, TET
–SXT, ERY, GEN
ESBL: Extended Spectrum Beta Lactamase
• Mostly Gram neg Bacteria
• Resistance against:
–Ceph-3rd
–Aztreonam
–Cross: FQ
–Others: ??
• Data Indonesia: Sensitive: AK, FOS,
MEM, TGC, PTZ/SCF
Plan
• Active Surveillance:
–Active, targeted surveillance
–High cost
• Passive Surveillance:
– Low Cost Surveillance
– Based on Routine data on Health
Care Services
– Centers: Hospitals
WHAT:
- The routine Lab Examination, paid by
system (Insurance)
- Centers: Hospital-2, 3 & Facilities: ?
- Many centers, representative of Regional,
National (Indonesia)
- Beneficial for Health Services & National
Policy Handling of Inf Dis
Passive surveillance
Target Selection:
• Ward: Surgical vs Medical
• Disease & Specimen:
–Pneumonia Sputum
–UTI Urine
–SSI Pus
• Hospital:
• Time: 2018
• Pathogens: Rank
Target Resistant Bacterial :
• All bacterial pathogens
• Specific bacterial Resistance:
– ESBL Producing bacteria
– MRSA
– Carbapenem Resistant Pseudo
aeruginosa
• Now in Indonesia:
– ESBL: range about 45-82%
–MRSA: range about 30-50%
An Example
1. The Prevalence & Susceptibility pattern of ESBL Producing bacteria in Dr. Haz Hospital Malang 2017
2. The pattern of bacterial agents and its susceptibility among sputum isolates in Dr Hiz Hospital Mojokerto 2017
3. The prevalence and susceptibility pattern of MRSA and MSSA in Huv Hospital Magetan 2017
4. The ESBL producing bacterial agent from Sputum and Urinary specimen in Han Hospital Solo 2017
An Example
1. The Prevalence & Susceptibility pattern of ESBL Producing E coli and Kl pneumoniae in Dr. Haz Hospital Malang 2017
Why E coli & K pneumo: 80-90% ESBL
Prevalence in: (E coli or K pneu or both) • Sputum • Urine • Blood • Pus
Susceptibility ESBL-E coli or K pneumo or Both against: CTX, CRO, FEP, AMC, AK, PTZ, SCF, MEM,
20
Producing microbes Total %
Citrobacter freundi 1 0.5 Citrobacter koseri 1 0.5 Citro werkmanii 1 0.5 Ent aerogenes 1 0.5 Entero cloacae 12 6 E coli 91 44 Kleb oxytoca 2 1 Kleb pneumo 93 45 Proteus mir 1 0.5 Seratia fonficola 1 0.5 Seratia marcescens 1 0.5 Total 205 100
ESBL Multicentre Study Jan-June 2010 Surabaya, Semarang, Malang
21
All Isolates Jan 2010 until June 2010 ESBL Producers Surabaya, Semarang, Malang
E coli (n=91) Kleb pne (n=93)
Antibiotic Res (%) Res (%)
Cefotaxim 89 97,8 87 93,55
Meropenem 0 0 3 3,23
Fosfomycin 4 4,4 3 3,23
Cefo-Sulb 3 3,3 4 4,30
Amikacin 7 7,7 8 8,60
Ciprofloxacin 68 74,7 43 46,24
22
Isolates Jan 2010 until June 2010 Specimens: ESBL Producers SBY, MLG
E coli (%) Kleb pne (%)
Specimen Sby
(n=46) Malang (n=18)
Sby (n=44)
Malang (n=26)
Urine 46 39 22 19
Blood 8 11 13 8
Pus 13 33 29 35
Sputum 11 11 31 31
Faeces 20 6 0 4
Others 2 0 5 4
Summary
• Surveillance targeting on: AMR & MDRO
• Plan: Active vs Passive
• Passive Surveillance Low Cost: Cost paid by Health Care System
• Specify:
– Selected ward or whole hospital wards
– Specified specimen: Blood, Sputum, Pus ??
– Specified Time: Jan-July 2018
– Specify: Targeted Bacteria: ESBL, MRSA, Acinetobacter baumanii ??