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<br /><br />E1308:<br />A Phase II Trial of Induction Chemotherapy Followed by Cetuximab with Low Dose vs. Standard Dose IMRT in Patients with HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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E1308:A Phase II Trial of Induction Chemotherapy Followed by Cetuximab with Low Dose vs. Standard Dose IMRT in Patients with HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx. Presented By Anthony Cmelak at 2014 ASCO Annual Meeting. Disclosures. - PowerPoint PPT Presentation

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Page 1: Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

<br /><br />E1308:<br />A Phase II Trial of Induction Chemotherapy Followed by Cetuximab with Low Dose vs. Standard Dose IMRT in Patients with HPV-Associated Resectable Squamous Cell Carcinoma of the Oropharynx

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Page 2: Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Disclosures

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Page 3: Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Slide 3

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Page 4: Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Background: HPV+ OP SCCa

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Page 5: Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Rationale: Cetuximab based Induction CT

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Slide 6

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Endpoints

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Statistics

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Results

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Slide 10

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Results: Acute Toxicity

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Late Toxicity

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Response: Induction

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Response: Following Cetux/IMRT

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Endpoint: 2yr PFS and OS

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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PFS and Survival: Dose

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Low Dose: T stage and N stage

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Page 18: Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

Smoking: PFS and Survival

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Best Outcome: <T4, T1-N2b, <10 pk-yr

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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First Failure Patterns: Low-dose pts

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Summary

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Conclusions

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting

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Designed and conducted by:

Presented By Anthony Cmelak at 2014 ASCO Annual Meeting