Presented by Andrew Cinderella

Samuel Danishefsky� Born 1936 in Bayonne, NJ� B.S. from Yeshiva University 1956� PhD from Harvard 1962� NIH post-doc fellow at Columbia, Stork Lab� 1963-1980 University of Pittsburg� 1963-1980 University of Pittsburg� 1980-1993 Yale University� 1993-present Columbia UniversityAwards� Wolf Prize in Chemistry with Stork� Arthur C. Cope Award� Benjamin Franklin Medal in Chemistry� National Academy of Science’s Award in Chemistry� >480 publications

Dynemicin A� Possible anti-tumor agent

� Binds to the minor-groove of the DNA double helix

� Most effective in rapid growth cells

Retrosynthesis

Approach

Early Synthetic Steps

Approach

Attempted Routes

Approach

Path II Synthetic Steps

Path II Synthetic Steps Cont.

Approach

Final Synthetic Steps

Conclusion� Dynemicin A was successfully synthesized in 33 steps.

� Overall yield of 0.13%

Questions???Thank you!!!