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CASE REPORT
Presentation, assessment andtreatment of depression in ayoung woman with learningdisability and autism
Karen Long, Harry Wood and Nan Holmes Weston Green Resource Centre, Weston Green
Road, Thames Ditton, Kingston, Surrey KT7 0HY, UK
Summary The association between autism and affective disorders in adults with learning dis-
ability (LD) is reviewed, alongside a discussion of some of the problems identi®ed
with the accurate differential diagnosis of depression in individuals with more
severe impairment. This case study describes the presentation, differential diagnosis
and treatment of a young woman with a severe LD, autism and depression. Beha-
vioural factors which were felt to re¯ect this individual's depressive disorder, but
which are not usually associated with the diagnosis of depression, are highlighted.
Further work on the development and re®nement of a reliable method of assessing
depression in individuals with LD and autism is discussed.
Keywords Autism, depression
Introduction
The thoughts and feelings of adults with learning disability
(LD) have received increased consideration over the past 2
decades of research. Seminal papers within the LD special-
ity have included: investigations into the thoughts and feel-
ings of clients within a psychotherapeutic context
(Symington 1981; Bailey et al. 1986); the assessment of
depressed thoughts and feelings (Kazdin et al. 1983; Meins
1996); and the assessment and treatment of anxiety (Lindsay
et al. 1989). Despite attempts to investigate the develop-
ment, nature, consistency and stability of emotions experi-
enced by adults with LD, there still remains a signi®cant
lack of detailed understanding of these areas.
The importance of being able to accurately diagnose
depression in people with LD has been stated in several
reports (Matson et al. 1980; Edelstein & Glenwick 1997).
People with LD are thought to be particularly vulnerable to
affective disorders because of the lack of control that they
often experience. Jacobsen & Schwartz (1983) found an
increased incidence in clients when there was a risk of com-
munity placement breakdown, labelling, rejection or infanti-
lization. Reiss & Benson (1985) also suggested that the
reduced opportunities many people with LD have in their
lives makes them vulnerable. Similarly, reports have shown
that there is an increased incidence of depression in people
with Asperger syndrome (Tantam 1991), and therefore, it
can be argued that people who suffer from autistic traits are
also more vulnerable (Abramson et al. 1992).
However, the dif®culties experienced by many people
with LD in terms of communicating their thoughts and feel-
ings make all forms of psychological and psychiatric distur-
bance, not least unipolar depression, particularly dif®cult to
diagnose. Pawlarcyzk & Beckwith (1987) have shown that
the DSM-III (APA 1980) criteria for depression may be of
limited use when working with people who are more
severely impaired. Symptoms such as a reduction in the
ability to think and disturbances in concentration are often
attributed to the person's LD rather than to any change in
affective functioning (diagnostic overshadowing). Similarly,
Meins (1995) and Edelstein & Glenwick (1997) noted beha-
viours and features associated with depression in people
with LD which are not identi®ed in the DSM [e.g. increased
self-injurious behaviour (SIB), vomiting, aggression, scream-
= 2000 British Institute of Learning Disabilities, British Journal of Learning Disabilities, 28, 102±108102
ing, incontinence and stereotypies]. Therefore, the diagnosis
of depression in people with LD often relies heavily on
interpretation/inference based on behavioural observations
and questioning carers. However, several studies have
reported on the use of surveys, questionnaires and semi-
structured interviews with both clients and their carers to
assess depression (e.g. Kazdin et al. 1983; Benson et al. 1985;
Reynolds & Miller 1985; Reynolds & Baker 1988; Benavidez
& Matson 1993; Meins 1993, 1996). Diagnosing depression
in people with severe LD and autism is an even more com-
plex area.
The present paper explores the presentation, assessment,
differential diagnosis and treatment of depression in a
young woman with severe LD and autism.
Case report
History
Ms X was a 19-year-old woman with autism and a history
of challenging behaviour, i.e. behaviour `of such an inten-
sity, frequency or duration that the physical safety of the
person or others is placed in serious jeopardy . . . ' (Emerson
et al. 1982). She was an only child. Her parents were both in
their mid-thirties when she was born. X's mother suffered
from depression. There was no history of psychiatric illness
on X's paternal family side. The family did not have a large
support network.
A diagnosis of autism was originally made at the Mauds-
ley Hospital when X was aged 2 years and 6 months. No
information was available as to what classi®cation system
or set of criteria were used to make the diagnosis at this
time.
She began attending a school for children with LD at the
age of 4 years and moved into full-time residential care at
the age of 6 years. Notes from X's early years in care
referred to her displaying SIB; for example, head banging,
kicking herself and refusing food. Early records stated that
these behaviours increased in severity when she moved into
full-time residential care, and subsequently, in her early
teenage years, when she also began hitting out at staff and
her peers. When X reached 18 years of age, her school place-
ment was terminated following staff reports that they were
unable to continue to provide a service for her or to main-
tain a safe environment.
She moved to a specialist health service assessment and
treatment unit for adults with LD in June 1997 for a com-
prehensive multidisciplinary assessment of her needs prior
to identi®cation of a long-term residential placement.
Presentation
On arrival, X was found to have extremely limited commu-
nication skills. She had very little spoken language, most of
which was based on her own neologisms. X knew few
Makaton signs. Her social interaction was limited to repeat-
ing single-word requests for biscuits, car rides or parties.
She made no attempt to interact with other residents. X was
also noted to have a number of ritualistic/repetitive beha-
viours: for example, she kept her arms inside her sleeves
and wore a hat constantly, and would balance any item
that was small enough on her head (e.g. pens, cushions and
tea towels). The diagnosis of autism according to the DSM-
IV criteria (APA 1994) was con®rmed by the multidisciplin-
ary team. Subsequent assessment of X's intellectual level
using the Leiter International Performance Scale (Leiter
1980) revealed that her IQ was 38.
Physical health and epilepsy
X was a tall, thin woman (height� 1�78 m, weight 1 46.35
kg). She suffered repeated urinary tract infections and was
on a daily dose of amoxycillin to help prevent these. X was
also on a low dose of carbamazepine because it was felt
that she might have been experiencing some form of epilep-
tic activity. At times, she would begin breathing heavily
and jerk her head backwards, or to the right side, and she
was known to have experienced six generalized seizures in
the years leading up to her admission to the assessment
and treatment unit. X had undergone a full medical exami-
nation, including a pelvic examination, under general
anaesthetic shortly before her admission. No major physical
abnormalities were detected.
Challenging behaviour
On admission, X's challenging behaviour included: SIB in
the form of hitting, kicking and punching herself, hitting
out at others, screaming and shouting for extended periods
of time, and refusing to join in group and individual activ-
ities.
Table 1 summarizes X's repertoire of challenging beha-
viours on admission to the unit.
Assessment
A comprehensive psychological assessment of X's beha-
viour began on admission. Staff working with her were
asked to complete detailed monitoring of the antecedents
and consequences of each individual episode of challenging
behaviour. Direct observations of her behaviour were car-
ried out at different times during the day by the assistant
psychologist, and videos were taken of X's challenging
behaviour to allow more detailed analysis by the clinical
team. Regular meetings (initially weekly) were held with
X's key workers to discuss the monitoring to ensure that
consistent records were kept. Table 2 and Fig. 1 show the
103Depression, learning disability and autism
= 2000 British Institute of Learning Disabilities, British Journal of Learning Disabilities, 28, 102±108
monthly frequencies of SIB taken from the monitoring
forms completed after each incident.
X was assessed by her general practitioner, who could
®nd no physical complaint that might have caused her chal-
lenging behaviour, and by a neurologist, who found no evi-
dence of epileptic activity at the time of assessment.
Formulation
The initial formulation made by the clinical psychologists
and other members of the multidisciplinary team was that
X's challenging behaviour was related to her frustration at
her inability to express her needs and desires effectively.
Much of her behaviour might have been caused by her lim-
ited communication skills. In addition to this, it was
stressed that X had been through several major life events
(i.e. leaving school and moving residential placement)
which were likely to have upset her routine and could have
caused her considerable distress. It was also felt that aspects
of her challenging behaviour could be self-stimulatory in
function.
Initial treatment
Detailed communication guidelines, including lists of the
Makaton signs and neologisms X used, and the meanings of
these symbols and utterances, were developed by the
speech and language therapist to facilitate communication
with X. These were used extensively in order to ensure that
all staff working with X were better able to understand her
communication. The speech and language therapist began
working with X to build on her use and understanding of
Makaton symbols.
She was assigned a one-to-one support worker to carry
out a highly structured activity programme, which was
designed by the Clinical Psychology Department and based
on many of the activities which X had enjoyed doing at
school. This provided her with stimulation and routine
until a suitable day placement could be identi®ed.
A reward programme, i.e. psychological intervention 1,
was started on 1 September 1997 which involved her being
given a sticker for every 15-min period in which she dis-
played no challenging behaviour during the day. However,
this programme was eventually discontinued because there
was no clear evidence that it was reducing the frequency of
challenging behaviour and staff felt that the process of
choosing a sticker had become a `chore' for X (see Fig. 1).
Secondary presentation
Although the initial frequency of X's challenging behaviour
was high (e.g. 25 incidents of SIB in August), staff who
were already experienced in working with people with
challenging behaviour felt that they were able, with the
support of the multidisciplinary team, to manage her beha-
viour and work with her to reduce the frequencies. Since X
had recently moved to the placement, this level of SIB pro-
vided a baseline. However, in October, several months after
her admission, X's SIB became much worse and reached a
level at which staff felt that her health and safety were at
risk (e.g. 115 incidents in a month). At the worst point, X
was engaged in SIB for up to 16 h a day. She remained in
her room and showed no interest in becoming involved in
activities, or in eating and drinking. Staff found that the
only way of safely protecting X during these extended peri-
ods of SIB was to sit with her and physically protect her
head, arms and legs. At times, it took three members of
staff to achieve this.
Table 1 Summary of challenging behaviours observed in the subject
Challenging behaviour Details
Self-injurious behaviour Hair pulling, hitting, kicking, scratching,
pinching, head banging and rectal
probing
Aggression to others Hair pulling, hitting, kicking and pinching
Screaming Over extended periods of time
Moaning Over extended periods of time
Shouting Over extended periods of time
Disengagement and isolation Withdrawal from groups and activities
Incontinence Including both nocturnal and diurnal
urinary and faecal incontinence, and
smearing
Table 2 Frequency of self-injurious behaviour (SIB) and dates of med-
ication changes
Date
Frequency
of incidents
of SIB Medication changes
August 25 ±
September 54 ±
October 115 Thioridazine (morning dose begun
11 October 1997; morning and
evening doses stopped 23 October 1997)
Paroxetine (begun 23 October 1997)
Zopiclone (begun 28 October 1997)
November 43 ±
December 12 ±
January 16 ±
February 37 Zopiclone (stopped 3 February 1998)
March 17 ±
April 7 ±
104 K. Long et al.
= 2000 British Institute of Learning Disabilities, British Journal of Learning Disabilities, 28, 102±108
Secondary formulation
The continued monitoring of X's challenging behaviour sug-
gested that there was a change in its character at the time
when her SIB became much more frequent and severe.
Therefore, it was suggested that she might be suffering
from problems in addition to her autism, severe LD and
associated communication disabilities. It was noted that
some of her behaviours (e.g. spontaneous crying, and dis-
turbed sleep and eating patterns) were similar to those asso-
ciated with depression. The DSM-IV (APA 1994) requires
two or more weeks during which a person shows at least
four of the following in order to diagnose depression:
1 a change in sleep (X was sleeping very little);
2 a change in appetite or weight (X refused food and was
losing weight);
3 a change in psychomotor activity (X spent much of her
time lying on her bed);
4 a reduction in energy; tiredness or fatigue (it was not pos-
sible to tell if X was experiencing this because of her com-
munication dif®culties; however, she was spending
extended periods of time resting on her bed);
5 feelings of worthlessness or guilt (it was not possible to
tell if X was experiencing these symptoms);
6 dif®culty in thinking, concentrating or decision making
(it was not possible to tell if X was experiencing these
symptoms); and
7 recurrent thoughts of death and suicidal ideation (it was
not possible to tell if X was experiencing these symptoms).
Although X was undoubtedly suffering from weight loss,
poor appetite and disturbed sleep, it was not possible to
know if she was experiencing decreased energy, tiredness,
fatigue, feelings of worthlessness or guilt, dif®culty concen-
trating, or suicidal ideation because of her dif®culties in
communication and the possibility of diagnostic over sha-
dowing (i.e. attributing the symptom to X's LD rather than
to changes in her mood; Matson 1983). Similarly, it was not
possible to assess obsessive rumination, an increase in anxi-
ety and phobias, worries about health, panic attacks, and
problems in relationships. Although X was evidently more
Figure 1 Frequency of challenging behaviours observed in the subject from August 1997 to March 1998: (a) Psychological intervention 1 introduced 1
September; (b) Psychological intervention 1 introduced 10 October; (c) morning dose of Thioridazine (25 mg) introduced 11 October (Evening dose 25 mg in
place from 6 June 1997); (d) Thioridazine (25 mg) bd discontinued 23 October; (e) paroxetine (20 mg) introduced 23 October; (f) Zopiclone 7�5 mg
introduced 28 October; (g) Psychological intervention 2 introduced 1 November; (h) Day service begun 25 January; (i) Zopiclone discontinued 3 February.
105Depression, learning disability and autism
= 2000 British Institute of Learning Disabilities, British Journal of Learning Disabilities, 28, 102±108
tearful and appeared to be more irritable than she had been
on admission, it was decided not to rely on the DSM-IV cri-
teria of depression in isolation and without modi®cation.
However, Edelstein & Glenwick (1997) reported that the
level of a person's LD can affect the presentation of depres-
sion and X's autism would serve to further complicate this.
Meins (1995) summarized the atypical symptoms of depres-
sion in adults with LD. Sovner & Hurley (1983) also sug-
gested that one has to rely upon changes in behaviour and
functioning, and a family history of affective disorders in
order to accurately diagnose depression in people with
more severe LD.
In order to make a differential diagnosis, substance mis-
use and dementia were both eliminated. Furthermore, X
had not suffered from any recent bereavements. There was
no evidence of schizo-affective disorder.
Table 3 shows the observations made of X's behaviour
which were consistent with the factors associated with the
atypical expression of depression in people with LD.
The multidisciplinary team hypothesized that it was
likely that X was suffering from a depressive illness, that
she could have been suffering from depression on admis-
sion and that this had become worse over time.
Secondary treatment
It was decided to treat X for depressive illness. She started
a course of Paroxetine at the end of October 1997. A second,
revised psychological intervention was introduced (Wil-
liams 1992). Staff began, with the support of the Clinical
Psychology Department, to encourage X to take part in
activities more assertively, and she was especially encour-
aged to go for short walks to post letters and visit the local
shops. Routine schedules were planned to encourage X to
join in with group activities and help with the housework,
and staff were asked to provide as much positive feedback
as possible for X while she was engaged in any activity. She
continued to receive one-to-one support in order to facilitate
her participation in more activities. Her parents were
encouraged to visit her on a regular basis and she was able
to visit the family home with close staff support. The Clini-
cal Psychology Department closely monitored all aspects of
X's challenging behaviour. As soon as she was well enough,
X was introduced to a specialist day centre for people with
LD and challenging behaviour. This took place in February
1998.
Outcome following treatment
Incidents of SIB dropped from a total of 115 incidents in
October 1997 to a total of 43 in November 1997 (see Table
2). Indeed, the baseline frequency of SIB (August 1997, 25
incidents) was surpassed as X showed a frequency of 12
incidents in December 1997 and 16 in January 1998 (see
Table 2). She became more interested in activities, began eat-
ing and drinking more, and sleeping better. Interestingly,
there was a slight peak in SIB in February 1998. This may
have been related to changes in X's daily routine following
the introduction to a specialist day service (25 January
1998). Levels of SIB dropped again after several weeks of
attendance (March 1998, 17 incidents; April 1998, 7 inci-
dents). Figure 1 shows the changes in X's behaviours.
X's aggression towards others began to rise in December
1997 (it had reached the lowest level in November 1997).
Her aggression towards others was hypothesized to be less
related to her depressive illness and separate psychological
intervention strategies were designed to address this pro-
blem.
Table 3 Observations made of the subject consistent with atypical expression of depression (Meins 1995; Edelstein & Glenwick 1997)
Atypical feature Observations made of subject
First-degree relative with a diagnosis of affective disorder Mother suffered from depression
Previous episodes of depression Unknown
Recent psychological stressor Left school and moved to residential placement in June 1997
Predominantly sad facial expression and ¯at affect Staff noted that she rarely smiled, and anecdotally reported that she looked sad much
of the time
Overactive behaviour; increase in stereotypic behaviour Foot stamping and rocking both increased in frequency during early October 1997
Self-injurious behaviour Frequency increased signi®cantly (see Fig. 1)
Aggression towards people and objects Withdrawal meant that she was not in contact with other people; high levels of self-injurious
behaviour often meant that she was too `preoccupied' to become aggressive to others
Screaming She began screaming for extended periods of time in October 1997
Loss of developmental skills Episodes of incontinence increased in October 1997, and as withdrawal increased, she showed
little interest in bathing, washing or dressing
Vomiting Not observed
Hallucinations No evidence of this was reported
Spontaneous crying Spontaneous crying was noted to increase in frequency in early October 1997
106 K. Long et al.
= 2000 British Institute of Learning Disabilities, British Journal of Learning Disabilities, 28, 102±108
Current situation
Combined psychological intervention and treatment with
Paroxetine continues. X is increasingly involved in activities,
and continues to attend a specialist assessment and treat-
ment day service for clients with challenging behaviour. X
still presents a range of challenging behaviours, including
SIB, but these are less intense and less frequent.
Multidisciplinary team members continue to be fully
involved in the assessment and treatment of X in terms of
facilitating her use of the day service, and consolidating an
understanding of her and her behaviour prior to identifying
possible future long-term residential and day placements.
Discussion
The team's work with client X highlights the practical dif®-
culties clinicians face when trying to make a differential
diagnosis of depression in people with LD, particularly
those with complex needs. The expression of depression in
people with severe communication dif®culties, autism and
LD has not yet been comprehensively investigated, and
diagnostic overshadowing may mean that disorders like
depression are not recognized rapidly and accurately.
Because it is likely that people with LD and autism are
particularly vulnerable to depression (Abramson et al.
1992), improving the ability to diagnose depression in this
client group should be a priority for clinicians. An approach
including monitoring of `unusual' behaviours (i.e. beha-
viours which are not usually observed in the individual),
symptoms highlighted in the DSM-IV, atypical symptoms
(Meins 1995; Edelstein & Glenwick 1997) together with the
completion of standardized assessment schedules and a
mental state examination would facilitate a more reliable
diagnosis of depression in people with LD.
The levels of SIB observed in X during her period of
intensely challenging behaviour had a severe impact on the
opportunities available to her in terms of community access
and participation in activities. She was also at considerable
risk of injuring herself. In retrospect, it may appear that X
was displaying obvious signs of a major depressive illness,
but at the time, other possibilities seemed equally likely.
Dif®culties in differential diagnosis were compounded
because X was not able to communicate verbally how she
was feeling.
The present authors are aware that the implications of
this research are somewhat limited because of its retrospec-
tive nature and single case study design. It was not possible
for ethical reasons to test out the depression hypothesis by
withdrawing treatments at a later stage. Similarly, data
relating to the frequency of behaviours associated with the
atypical expression of depression (e.g. screaming and with-
drawal) were not recorded at the time. Such behaviours
were noted anecdotally by X's key workers to have
increased in frequency as the SIB increased. In hindsight, it
would have been invaluable to have recorded these beha-
viours more systematically. As a single case study, the pre-
sent paper aimed to describe atypical signs of depression in
a person with LD and autism, and the practical treatment
provided based on this diagnosis.
Future research should be directed towards an evaluation
of formal approaches to the assessment of depression in
people with LD and those with the additional handicap of
autism with the ultimate goal of producing standardized
tests which may be used with people with more severe LD,
autism and communication dif®culties. This would
undoubtedly lead to an improvement in quality of life for
people with similar needs to X.
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