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Preparedness, Coordination, Monitoring
\
Prepared with the support of Peacepath Consulting
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Three Kinds of Influenza
• Seasonal Influenza-An annual pattern-Usually mild, but can be serious – even fatal – in elderly-Routine vaccination available
• Avian Influenza (“Bird Flu”)-Current epidemic of Highly Pathogenic Avian Influenza in Asia and entering Europe
• Pandemic Influenza- Intermittent, Major morbidity and mortality, Economic and social consequences
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Past Influenza Pandemics
1900
1850
1950
2000
1847
1889
1918
19571968
42 yrs
29 yrs
39 yrs
11 yrs
30 – 40 years cycle
No Pandemic for > 35 yearsNo Pandemic for > 35 years
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Mortality during the pandemic of 1918-19
3 epidemic waves in close succession
March 1918, Sept 1918, Feb 1919
Est 40 million deaths world-wide,
A/H1N1 – Spanish influenza
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Pandemic Geographic spread: 1918-19
?01/19
03/1804/18
06/18
05/18
06/18
06/18
?
C.W. Potter, Textbook of Influenza, 1998
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Pandemic Geographic spread: 1957-58
02/57
04/57
06/57
05/57
06/57
07/57
08/57
06/57
07/57
C.W. Potter, Textbook of Influenza, 1998
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Why is it a threat to humans?What is the “Bird Flu”?
Overview
2. Influenza viruses can be highly transmittable (e.g. airborne)
3. The H5N1 virus could change and become transmissible between humans
1. The human population has demonstrated low immunity to the H5N1 strain with high mortality2. Outbreaks have occurred
in poultry, migratory birds and other fowl across SE Asia, Europe and Russia
3. This “Bird Flu” has caused millions of poultry deaths, affected household economies & infected humans
1. H5N1 is a new strain of influenza virus present in birds
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Threat of H5N1 Human Influenza
Prerequisites for a pandemic:
1. A novel influenza virus must emerge to which the general population has little or no immunity and for which there is no effective vaccine
2. The new virus must be able to replicate in humans and cause disease
3. The new virus must be efficiently transmitted from one human to another
?
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What do we know….
• Pandemic influenza will happen (at some point)
• It is more likely now than three years ago
• It could be mild
• It could be severe
• It could be extremely severe
• It affects younger age groups than "normal" influenza
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What do we know - Two
• It could come once or in waves
• It will probably come quickly
• Work forces will be badly affected
• Economies will be disrupted
• Maybe infectious before symptoms appear
• There are infections with no symptoms
• Modelling suggests that containment will not be easy
• The time between detection and effective response is very short
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What do we know - Three
• Influenza is infectious – but not as highly infectious as measles
• Not everyone will be infected
• There are ways of reducing the numbers affected
• If an infectious and damaging virus emerges, containment of people may be justified
• An effective vaccine will take several months to develop
• There will probably be many less anti-viral medicines available that will be requested by governments; the emergence of resistance is possible
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Strategy
• take action to contain the avian influenza epidemic through upgrading veterinary infrastructure, improving bio-security and changing patterns of bird trade,
• prepare for the next pandemic with vastly improved surveillance, stockpiled anti-virals and other medicines, protective clothing, containment plans, and
• be ready to respond to the pandemic in ways that keep vital services and societies going and minimise suffering. When the pandemic starts it will be too late to get prepared
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WHO has a classification for threat level …
Inter-pandemic
period
Phase 1 No new influenza virus detected in humans. If a new influenza virus presents in animals, the risk of human infection is considered to be low.
Phase 2 No human infections, but a circulating animal influenza virus poses a risk to humans.
Pandemic alert period
Phase 3 Human infection(s) with a new virus, but no (or very infrequent) human-to-human spread.
Phase 4 Small cluster(s) with limited human-to-human transmission but spread is highly localized.
Phase 5 Larger cluster(s) but human-to-human spread still localized
Pandemic period
Phase 6 Increased and sustained transmission in general population.
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Humanitarian Engagement
• Critical roles of statutory and voluntary bodies, at global, regional, national and local levels (National Governments, WHO, FAO….
• Information Sharing: Risks, Threats, Preparedness and Response
• Agreed working relationships and protocols: International volunteer bodies, civil society at country level, National authorities, International organizations
• Preparedness planning among IASC membership through existing processes
• Preparedness planning, including scenarios and simulations, through dedicated new process
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The Coordination Challenge
Uncertainties • Nature of the AI / HI threat (severity, reach)
• When and where escalation will occur
• Duration of AI / HI presence
Certainties • Local threat with global implications
• Countries have variable capacity to prevent, prepare and respond
• Short window of opportunity for initial assessment and robust response
• Indirect behaviours (e.g. public reaction, media response, government actions) will influence the operating environment as much as the direct behaviours of the AI or HI virus
Several factors influence the complexity of the AI/HI coordination challenge:
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Implications for Approach
1. Ensure accurate, timely, relevant and transparent exchange of information
2. Generate clear, consistent and timely messages on the status of the situation
3. Facilitate unprecedented levels of trust and joint action across agencies, actors and levels
4. Enable the international community to optimally deploy global resources (technical, human, financial) to minimize the global impact on lives and livelihoods
5. Build on existing processes where possible
To succeed, Avian and Human Influenza coordination mechanisms must:
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ObjectiveTo facilitate a collaborative process among key actors to transform:
A collection of organizationsworking independently toward
individual objectives
The inefficient use of collective experience,
expertise and resources
A community of organizations and active networks working
together to achieve common objectives
An optimal use of collective experience, expertise and resources
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Levels of CoordinationCoordination will be active at three broad levels:
Country LevelCoordination
1
Working LevelCoordination
2
Global Level Coordination
3
Provide local leadershipIntegrate and inform global teamsImplement preparedness & response
Facilitate information exchangeSet global standardsPrioritize activities against objectives
Align strategyTrack progressIdentify gaps and blocksDrive Resolution
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Proposed FrameworkTo provide coordinated operational and technical support:
National Coordination Mechanism (Country Led)Integrated Country Plan
International Consortium on Avian & Pandemic Influenza(Countries, Agencies, Financiers, Civil Society)
Working Level CoordinationFinancing Partners: MDBs, Bilaterals,
etcPrivate Initiatives
Regional Organizations:
APEC, ASEAN , etcFAO OIE WHO
IASC membership
Alignment and Harmonization
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In Practice – Country Level
Sector Stakeholders
Beneficiaries
• National Government central actor in coordination
• Propose the use of existing coordination arrangements that bring in UN system agencies, Development Banks, OIE, Key Financiers, Other stakeholders (such as Red Cross, Private Sector, Civil Society)
• Strengthening capacities of regional networks and organizations, particularly so they can effectively support coordination on cross-border issues.
• Encourage cooperation on research and development
• Quick and flexible mechanism to draw down funding to finance control in event of a major outbreak.
• Ensuring specialized institutions (FAO, OIE, WHO and others) are equipped to provide standards, policy and technical guidance and to support capacity building, in response to country needs
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In Practice – Global Level
• To ensure collective responsibility for response to AI and pandemic threat (from new and emerging infections) from a global perspective within a set of agreed principles
• To take on High Level coordination functions (a) aligning strategy, (b) tracking progress, (c) identifying gaps and blocks, (d) driving progress to results
• Establish global goals, promote international standards, monitor regularly, and adjust the overall effort as needed
• Take on and address challenging policy, financing, and access issues, provide guidance on ways in which they can best be addressed
• Support could be provided jointly by UN System Influenza Coordinator, and World Bank with other relevant bodies
Consortium composed of high-level representatives of countries affected or at risk, international technical agencies, financiers, regional bodies, civil society.
Functions include:
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Strategy framework to guide integration and alignment of strategies generated by the working level teams
UN System Coordinator Contributions
1
Tool for tracking progress against critical activities and objectives (e.g. dashboard)
2
Information on where and why resources required, upon which financiers can base investment decisions
Targeted analysis to identify possible scenarios and risks as the situation evolves and implications for prevention,
preparedness and response
3
4
The UN Coordinator will aim to provide the following inputs to the consortium:
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Coordinator for Avian and Human Influenza
Instruments, information and systems for effective coordination within UN system and synergized UN system links with other involved parties
Countries: Coordinated support (through RCs and UN/Bank Country Teams) (i) track influenza situation, , implementation of integrated national plan, coordination of support overall effectiveness of programmes
(ii) stimulate effective actions, fill gaps, reduce duplication undo blocks
UNDGOBCPRWhole UN Country Teams
Harmonized communications on influenza issues; consistent messages to communicate risk and stimulate specified behaviours strategic dissemination of chosen messages ensuring strategies are fully implemented through multiple networkscoordinated communication through UN system
Preparedness and Contingency Planning: UN system R/Cs and IASC country teams, and regional offices, support cross-sectoral pandemic response and containment planning(a) both within and between countries; (from region to global), (b) between UN system and each country’s authorities (c) throughout the UN system at each level (and link efforts to keep staff safe):
Seeking resolution on difficult policy decisions: (i) availability of stocks of antiviral medicines, their distribution in the event of need: (ii) means for triggering changes in alert levels (iii) vaccine development, (iv) response and containment, access to PPM(v) rapid improvement in animal health services(vi) marshalling of science and technology
Engagement in Policy Initiatives: Constructive interactions between the UN system/World Bank/IASC and partnerships of decision makers)
Working-level inter-agency coordination & synergy of UN system -external linkages Interagency strategy; Engagement by humanitarian agencies; Engagement with private entities, NGOs, militaries, academics, foundations, prof assocs; information network financial tracking services
Regional level: coordination support
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Potential Dashboard ToolPriority 1 Priority 2 Priority 3
Issue Human Vaccine Supply Veterinary System Strengthening
Increasing Public Health Laboratory Capacity
Lead Agency WHO OiE / FAO WHO
Status of Strategy Complete Level of stakeholder commitment Assessment of alignment with other priorities
Key Outcome Targets xx% increase in global production capacity
xx funded trials of approaches to extend reach of doses (e.g. antigen sparing, intradermal)
xx% of forecasted global pandemic vaccine supply secured for central UN management and distribution
Policy Initiatives Global principles for revising regulatory pathways under pandemic risk
Current Capacity Deployed / Required % Surge capacity % regions covered
Funding Required $xx M (USD)
Funding Received $xx M (USD)
% of Funding Target xx%
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Pandemic Preparedness
Strengthened capacity to successfully combat the AI / HI threat
1. Pandemic will have extraordinary impact on economic Avoids duplication of efforts
2. Optimizes use of global assets and resources3. Facilitates knowledge transfer and active learning as
the situation evolves4. Provides a forum for building strong, effective working
relationships before a full scale crisis hits
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Thank you