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2Disclaimer
Neither this presentation nor any verbal communication shall constitute, or form part of, any offer, invitation orinducement to any person to underwrite, subscribe for, or otherwise acquire or dispose of, any shares or othersecurities in Circassia Pharmaceuticals plc (“Circassia”).
Forward-looking statements
This presentation and information communicated verbally to you may contain certain projections and otherforward-looking statements with respect to the financial condition, results of operations, businesses andprospects of Circassia. The use of terms such as “may”, “will”, “should”, “expect”, “anticipate”, “project”,“estimate”, “intend”, “continue”, “target” or “believe” and similar expressions (or the negatives thereof) aregenerally intended to identify forward-looking statements. These statements are based on current expectationsand involve risk and uncertainty because they relate to events and depend upon circumstances that may ormay not occur in the future. There are a number of factors which could cause actual results or developments todiffer materially from those expressed or implied by these forward-looking statements. Any of the assumptionsunderlying these forward-looking statements could prove inaccurate or incorrect and therefore any resultscontemplated in the forward-looking statements may not actually be achieved. Nothing contained in thispresentation or communicated verbally should be construed as a profit forecast or profit estimate. Investors orother recipients are cautioned not to place undue reliance on any forward-looking statements contained herein.Circassia undertakes no obligation to update or revise (publicly or otherwise) any forward-looking statement,whether as a result of new information, future events or other circumstances.
3Period of challenges and new opportunities
Expanded commercial infrastructure as strategic growth platform
NIOX® revenues continuing robust growth
Exciting collaboration and commercial rights transaction with AZ
Three COPD products added to specialty portfolio
Respiratory pipeline continuing to advance
Rapid action to halt allergy investment following disappointing results
Strong balance sheet (£117.4m cash at 31 December 2016)
Emerging as strong specialty pharma business
4
Respiratorynovelformulations- Added Tudorza®
and Duaklir®- Novel
formulations
Broad and balanced specialty pharma business
Specialty commercial infrastructure captures product value- Doubling US commercial presence; UK team launched; China & Germany presence strengthened
2
Transforming commercial profileBusiness built on multiple pillars
Commercialplatformexploitation- AZ transaction
exploits &expands platform
- Positioned forM&A, in-licensing& partnering
Out-licenseout-of-scopeassets- ‘Triple’ and LAMA
formulation
NIOX® asthmamanagementfranchise- Robust revenues- Strong sales
growth
SPIRE allergyproducts- Investment
halted followingHDM data
1 5 6
Strategy underpinned by robust balance sheet (£117.4 million cash at 31 December 2016)
Respiratorydirectsubstitutes- Target approved
drugs- Pipeline
strengthened
3 4
5
Product Research Preclinical Phase I Phase IIRegistration study /
SubstituteFiled /
ApprovedMarketed
NIOX VERO® / NIOX MINO®
Tudorza® US*
Duaklir® US
Flixotide® substitute**
Seretide® substitute
Flovent® substitute**
Spiriva® substitute
Cat SPIRE
Grass SPIRE
House Dust Mite SPIRE
Ragweed SPIRE
Birch SPIRE
Novel LABA / LAMA formulation
Novel COPD therapy formulation
Evolving portfolioApproved, nearer-term and earlier-stage products
*Commercial collaboration
**Partnered
Initial work onCOPD products
Allergydevelopment halted
Exciting new commercialcollaboration
New substitute producttargeting Spiriva®
6Business restructured
Facilities consolidated
– US and Swedish facilities consolidated onto single sites
– One Oxford premises vacated
– Facilities costs to reduce 40%
Non-commercial headcount reduced
– G&A 15% lower than end H1 2016
– R&D 20% below end H1 2016
– Further review of R&D requirements following house dust mite allergy results
●
●
Chicago
Morrisville
●●
Uppsala
Solna
●
Oxford
Cost reductions streamline business and increase efficiency
7
NIOX® asthma management
AstraZeneca partnership
Respiratory pipeline
1
2
3
SPIRE allergy therapies4
Summary6
Financial results5
8
NIOX® is only point-of-care FeNO device available across all major markets
Clinical evidence shows FeNO monitoring improves asthma management
– Improves diagnosis
– Improves determination of inhaled steroid responsiveness
– Improves stepwise dosing of inhaled steroids
– Improves monitoring of asthma control and treatment adherence
– Potential to reduce exacerbations
Research sales for use in big pharma clinical studies
− Validates importance; trains physicians; raises profile in asthma community
− Revenues dependent on study numbers and timings
Leadership in FeNO asthma management
NIOX VERO®
Launched in major markets
Ages 4+ EU; 7+ in US
6 and 10 sec test; ~60 sec result
Monitor lasts 5 yrs / 15,000 tests
9
Strong specialty commercial infrastructurePlatform for growth
Sales force expanded to 99territories
Managed markets, key accountsand medical affairs teams in place
Global commercial platform significantly strengthened
Expanding EU presence
UK direct sales team launched
German team strengthened
Beijing-based team managelocal distributors
Team strengthened with marketaccess and medical functions
Field Reps99 Specialty
RepresentativeTerritories
KeyAccounts7 US based
Marketing3 US based
MedicalSupport
3 US based
ManagedMarkets
6 US based
CommercialOperations5 US based1 US trainer
Strong US team
10
NIOX® installed baseNIOX® installed base
Clinical devices and tests growingFoundations in place to boost NIOX® sales
Test sales (‘000s)Test sales (‘000s)6,469 7,152
8,702
FY 2015: 2,878
FY 2016: 3,612
Maintaining steady growthMaintaining steady growth
7,385
FY 2013: 1,816
FY 2014: 2,265
11Strong NIOX® performance
23% growth vs 2015 (10% CER)
35% increase in clinical sales (21% CER)
6% decrease in research sales (16% CER)
17 key US accounts signed Q1 2017
6 additional health systems (>2.8m lives) coveringNIOX® Q1 2017
57% growth in US clinical sales Q1 2017 vs Q1 2016
US March 2017 sales best month since launch
Robust revenue growth
12
US experience program
− Approximately 900 NIOX VERO® placed
− Time to sale reduced ~25% vs 2015
− 2017 initiative focused on customer conversion
2017 UK / German evaluation programs
− Joint initiative with CCGs (UK) / physicians (Germany)
− Trial period (UK) / trial tests (Germany)
− Collect and review data demonstrating case for NIOX®
Focus on additional territories
− Appointing new French and Italian distributors
− New distributor management approach
− Recent Canadian approval of NIOX VERO®
Positive indication extension studies
− US pediatric study
− European primary ciliary dyskinesia diagnosis
Positioned for growthPositioned for growth
Targeting further growth
13
Positive results in US label extension studyFiling submitted for children aged 4 – 6 and 6 second test mode
Observed FeNO in evaluable population with 2 valid measurement in each mode
4 years (n=9) 5 years (n=27) 6 years (n=32) All (n=68)
Average FeNO 6 sec mode
Mean 14.8 20.7 23.2 21.1
Standard deviation 11.72 14.47 15.61 14.76
Average FeNO 10 sec mode
Mean 14.4 20.1 23.1 20.7
Standard deviation 11.51 14.39 15.34 14.59
Paired difference (average 10s mode - average 6s mode)
Mean -0.4 -0.6 -0.1 -0.4
Standard deviation 0.74 3.28 3.99 3.41
14
Nasal NO measurement from both nostrils
Optimal Cut-Off Specificity Sensitivity
Tidal breathingmethod
171 ppb(AUC 99.8%;PPV 100.0%;NPV 98.9%)
100% 98.0%
Velum closedexpiration againstresistance method
356 ppb(AUC 98.7%;PPV 93.1%;NPV 98.8%)
96.3% 97.8%
AUC = area under curve
NPV = negative predictive value (above optimal cut-off)
PPV = positive predictive value (below optimal cut-off)
TBM = tidal breathing method
ERM = velum closed expiration against resistance method
Positive results in PCD registration studyCertification update in coming months
15Potential to predict response to biologics
FeNO identifies likely (and unlikely)
responders to Xolair® (omalizumab)
- $10,000 - $30,000 per year treatmentfor moderate-to-severe allergic asthma
CI = confidence intervalMean percent reduction (95% CI) in protocol-defined asthma exacerbation rate in low- and high-biomarker subgroups (baseline fractionalexhaled nitric oxide [FeNO], peripheral blood eosinophils, and serum periostin)*Exacerbation reduction P values; omalizumab versus placebo in each biomarker subgroupHanania et al. Am J Respir Crit Care Med. 2013;187:804-811
Asthma exacerbation reduction by biomarkerAsthma exacerbation reduction by biomarker
16FeNO-directed therapy reduces exacerbations
Syk et al. J Allergy Clin Immunol Pract. 2013;1(6):639-648.
FeNO group had reduced time tofirst exacerbation
FeNO group had reduced numberof subjects with exacerbations
17
High FeNO group (>50ppb) n=1,016
Baseline corticosteroid use 852 / 1,016 (83.9%)
Change in corticosteroids based on FeNO 695 / 852 (81.6%)
Stepped down 20 / 695 (2.9%)
Stepped up 668 / 695 (96.1%)
Data presented at 2017 AAAAI‘Real world’ data on FeNO impact on treatment decisions
Effect of FeNO measurement on treatment decisions
Clinical impression match to FeNO
High vs FeNO > 50 ppb
18
NIOX® asthma management
AstraZeneca partnership
Respiratory pipeline
1
2
3
SPIRE allergy therapies4
Summary6
Financial results5
19
Transformational products
Adds Tudorza® in US
Adds Duaklir® phase III (approved in EU) as market moves towards LAMA / LABAs
Products feature Pressair® potential best-in-class device
Transforms Circassia’s commercial profile
Doubles marketed products with potential to triple in two years
Funds significantly broader commercial infrastructure
Transitioning Circassia into world-class respiratory business positioned for further licensing and M&A
Attractive transaction structure Total consideration $175m - $230m plus Duaklir® deferred royalties
$50m equity upfront with maximum $180m deferred consideration anticipate funded by debt (vendor loan back stop)
Commercial expansion and R&D contribution addressed by profit share collaboration
Transaction expected to deliver profits after one year
US infrastructure crucial for transformationaltransaction with AstraZeneca
Commercial collaboration, option and sub-license of US product rights
20
Tudorza® Pressair®
LAMA – maintenance bronchodilatorfor adults with COPD
$80m sales in US
Broad clinical database
– Three pivotal studies
– H2H vs Spiriva®
Aclidinium bromide (400µg twice daily)
Comparison vs market leading LAMA (tiotropium; Spiriva®)
*p<0.05 vs tiotropiumBoth treatments statistically significantly higher than placebo at all time pointsBeier et al COPD 2013
21
Duaklir® Pressair®
LAMA / LABA fixed dose combination
Approved in ~50 countriesincluding EU for adults with COPD
Broad clinical database
– Two pivotal studies
– Study vs Seretide®
Identical product in phase IIIdevelopment for US market
Aclidinium / formoterol (400µg / 12µg twice daily)
The Duaklir® trademark is registered in the United States;the mark is not currently approved for use by FDA
*p<0.05****p<0.0001Adapted from Singh et al BMC Pulm Med 2014; D’Urzo et al Respir Res 2014
FEV1 1hr post-morning doseFEV1 1hr post-morning dose FEV1 morning pre-dose (trough)FEV1 morning pre-dose (trough)
Study1
Study2
22
Pressair® inhaler offers significant advantagesPotential best in class mDPI used for both Tudorza® and Duaklir®
p<0.0001 vs comparator
Strong patient preference
Van der Palen et al. Expert Opin Drug Deliv 2013;Chrystyn et al. ERS 2014; LAC39: data on file
Groups more likely to report COPD:
Current / former smokers
Aged over 65
Women
History of asthma
More likely among COPD patients:
Activity limitations
Unable to work
Require equipment such as portableoxygen tanks
Increased hospital stays
Other chronic diseases
US COPD patient profileUS COPD patient profile
23
GOLD COPD guidelines updated for 2017Support LAMA and LABA / LAMAs as preferred treatments
LAMA + LABA LABA + ICS
LAMA
Furtherexacerbation(s)
Group C Group D – most severeConsider roflumilast ifFEV1 < 50% pred. and
patient has chronicbronchitis
Consider macrolide (informer smokers)
LAMA + LABA+ ICS
LAMA LAMA + LABA LABA + ICS
Furtherexacerbation(s)
Furtherexacerbation(s)
Persistentsymptoms / further
exacerbation(s)
Group A - least severe
Continue, stop or tryalternative class of
bronchodilator
A bronchodilator
evaluate effect
Group B
LAMA + LABA
A long-actingbronchodilator
(LABA or LAMA)
Persistentsymptoms
From the Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017.Available from: http://goldcopd.org.
PreviouslySAMA or
SABA
PreviouslyICS + LABA
or LAMA
PreviouslyICS + LABA
and / orLAMA
24
Market # HCPs Annual Annual
Decile # HCPs % Reach Reached Calls/HCP Calls
10 129 50% 65 18 1,165
9 424 50% 212 18 3,816
8 1,191 50% 596 18 10,722
7 3,011 50% 1,505 12 18,064
6 5,717 0% - - -
5 9,148 0% - - -
4 13,724 0% - - -
3 21,029 0% - - -
2 36,690 0% - - -
1 167,111 0% - - -
TOTAL 258,174 1% 2,378 14 33,766
*Excludes prescribers reached in left table
Tudorza # HCPs Annual Annual
Decile # HCPs % Reach Reached Calls/HCP Calls
10 248 95% 236 36 8,482
9 525 95% 499 36 17,955
8 837 95% 795 36 28,625
7 1,242 95% 1,180 24 28,318
6 1,786 95% 1,697 18 30,541
5 2,538 95% 2,411 18 43,400
4 3,496 95% 3,321 12 39,854
3 4,788 95% 4,549 12 54,583
2 7,675 0% - - -
1 23,444 0% - - -
TOTAL 46,579 32% 14,687 17 251,758
Focused call plan reaches major prescribers
Expanded sales force to target top 8 Tudorza® prescriber deciles
~15k prescribers responsible for 80% of Tudorza® prescriptions
Complement with top 4 deciles of COPD prescribers (non-Tudorza®) in areas with positive payer coverage
Targeting top Tudorza® prescribers Targeting top COPD prescribers (non-Tudorza®)
Data sourced from IMSHCP = healthcare professional
+
{Top40%Top
80%
25Significant progress executing plan
US sales force expansion by 100− Over 2,000 applied; 44 already recruited with remainder in final stage
Strong support team– 8 regional sales managers – 6 positions filled– Area sales director – position filled– Marketing director – offer stage– 5 medical science liaisons – 3 positions filled– Sales training manager – position filled– Senior analyst – position filled
Existing sales force training this week
Use AstraZeneca training, marketing materials and data
Circassia Tudorza® promotion to begin 8 May
First expansion wave (~75) training from 8 May begin promotion 22 May
Rapid expansion to 200 with full promotion starting 5 June
Tudorza® #1 in sales call & higher frequency increases intensity
26
NIOX® asthma management
AstraZeneca partnership
Respiratory pipeline
1
2
3
SPIRE allergy therapies4
Summary6
Financial results5
27
Particle-engineered respiratory productsNear-term pipeline & longer-term novel formulations
73.5% of pre-entry brand
price for first to market
generic in US during
exclusivity1
Significant pricing potential
1 Bureau of Economics, Federal Trade Commission, Working Paper No 317. The effect of generic drug competition on generic drug prices during the Hatch-Waxman 180-day exclusivity period. April 2013.
Device types
DPIpMDI
Directly substitutable products
– Limited development
– Abbreviated route to market
– No requirement for significant promotion
– Challenging to achieve for respiratory products
Novel formulations
− Longer more extensive development
− Develop specialty products
Novel technology controls API properties
28
Fliveo® EU rightsTargeting direct substitution of GSK’s Flixotide® pMDI
1 Partner rights: USA, Canada, Australia and New Zealand, India, Europe (including the EU and EFTA states (Iceland, Liechtenstein, Norway and Switzerland)), Turkey, Russia and CIS
Originator pMDI / DPI sales $866m (~60%US)
Partnered with Mylan1
Main market US
Discussions initiated for return of EU rights H2 2016
Product approved in all three strengths in UK
Smaller EU market potential opportunity for Circassia
Plan to determine EU approach in coming months
Targeting EU roll-out
29
Seriveo® targets Seretide® pMDI substitutionOriginator pMDI / DPI sales $4.7bn
Salmeterol (Seriveo® vs originator)
Fluticasone (Seriveo® vs originator)
Marked improvement vs previous study
Plan to reiterate pharmacokinetic study
UK filing anticipated H1 2019
3030
Three new COPD products added to pipelineSpiriva Handihaler® substitute targeting $3.3bn originator revenues
Pharmacokinetic study planned for H1 2018
In vitro comparison of engineered substitute vs Spiriva®
Deep lungdelivery
Non-inhaledportionof dose
Two further product opportunities in development
− Target underserved segment of specialty COPD market
− LABA / LAMA targeting up to $700m opportunity in US + EU5
− Exacerbation reduction therapy targeting up to $250m opportunity
31
NIOX® asthma management
AstraZeneca partnership
Respiratory pipeline
1
2
3
SPIRE allergy therapies4
Summary6
Financial results5
32House dust mite SPIRE phase IIb study
Robust study designRobust study design
Double-blind, randomized, multi-center field study
― Four arms (4 x 12nmol; 8 x 12nmol; 4 x 20nmol; placebo)
― Large population (4 x 12nmol n=180; 8 x 12nmol n=178; 4 x 20nmol n=178; placebo n=178)
Primary endpoint: difference in combined TRSS / rescue medication use
score one year after start of treatment vs placebo
― Same endpoint as previous cat SPIRE phase III field study
Inclusion criteria minimize confounding factors
― Moderate to severe allergy: baseline TRSS ≥12
― Subjects with laboratory confirmed house dust mite allergy
33
Mean Combined Score 50-52 weeks after treatment initiation
HDM SPIRE results mirror cat SPIRE phase IIIPrimary endpoint - efficacy
Primary endpoint: combined TRSS (0-24 scale) and rescue medication use (RMS) score (0-3 scale)
- Combined Score (0-6 scale) = (TRSS / 8) + (RMS)
ITT populationPlacebo(n=178)
4 x 12 nmol(n=180)
4 x 20 nmol(n=178)
8 x 12 nmol(n=178)
Mean Combined Score (baseline) 2.89 2.78 2.76 2.80
Mean Combined Score (50-52 weeks) 1.76 1.81 1.63 1.56
Combined Score improvement from baseline 39.1% 34.9% 40.9% 44.3%
LS mean difference vs placebo (50-52 weeks) 0.12 -0.05 -0.16
p value vs placebo 0.2641 0.6539 0.1356
34
Chamber vs field study symptom comparisonIncreased placebo effect in the field
TRSS at baseline and 1 year
45.6%35.8%
19.7%
40.4%
35
0.0
2.0
4.0
6.0
8.0
10.0
12.0
14.0
16.0
Phase IIb Phase III
Mea
nT
RS
S
Placebo (baseline) Placebo (1 year) 4 x 6 nmol (baseline) 4 x 6nmol (1 year)
Cat SPIRE phIIb vs phIII symptom comparisonDramatic placebo response in phase III study
TRSS at baseline and 1 year
61.0%59.5%46.5%
18.2%
Investment in allergy portfolio stopped
36
NIOX® asthma management
AstraZeneca partnership
Respiratory pipeline
1
2
3
SPIRE allergy therapies4
Summary6
Financial results5
37
Financial highlightsYear ended 31 December 2016
Full year results for 2016 differentiated from 2015 by two main factors
– Goodwill impairment allocated to allergy franchise for potential future benefit of acquiredAerocrine sales infrastructure
– Contributions from NIOX® and respiratory business for full year 2016
Underlying loss for 2016 £57.4m (2015: £50.0m)
– Provisions and impairment of allergy portfolio goodwill and other intangibles £77.2 million
– Restructuring costs and provisions for closure of Chicago and Solna offices £2.8m
– Allergy R&D expenditure £19.1m (2015: £30.5m) of which £5.3m in H2
Cash at 31 December 2016 £117.4m (31 December 2015 £203.8m; 30 June 2016: £138.0m)
– Contingent £30.0m consideration paid January 2016 to Prosonix ex-shareholders
– £3.2m payment for remaining 2.1% of Aerocrine issued share capital
– Cash decrease H2 2016 £20.6m
– Business remains well funded
38
Income statementYear ended 31 December 2016
Underlying Non-underlying Total Total Change
operations items 2016 2015
£m £m £m £m £m
Revenue 23.1 - 23.1 10.8 12.3
Cost of goods (8.0) - (8.0) (4.3) (3.7)
Gross profit 15.1 0.0 15.1 6.5 8.6
Sales and marketing (28.9) (75.8) (104.7) (13.5) (91.2)
Research & development (42.3) (3.9) (46.2) (46.8) 0.6
Administrative expenditure (15.4) (0.3) (15.7) (13.7) (2.0)
Other gains - - - 1.1 (1.1)
Operating loss (71.5) (80.0) (151.5) (66.4) (85.1)
Finance income net 6.0 - 6.0 3.5 2.5
Share of profit of joint venture 0.6 - 0.6 0.1 0.5
Loss before tax (64.9) (80.0) (144.9) (62.8) (82.1)
Taxation 7.5 - 7.5 12.8 (5.3)
Loss for the financial year (57.4) (80.0) (137.4) (50.0) (87.4)
39
Income statementYear ended 31 December 2016
Revenues
– Sales increased 23% from £18.7m (10% CER)
– Clinical sales increased 35% to £18.0m (21% CER)
– Device sales grew to £1.7m (CER 2015: £1.3m, 31%)and tests to £16.1m (CER 2015: £13.3m, 21%)
– Steady growth continued over first quarter 2017
– Research sales decreased 6% (16% CER)
Sales and marketing
– £74.5m allergy franchise goodwill impairment
– Increase in field force
Net finance income
– Includes £5.2m fx gain due to sterling weakening
Taxation
– Includes R&D tax credit £8.6m (2015: £10.3m)
– Lower qualifying R&D spend
– Deferred tax movements
2016 2015 Change
£m £m £m
Revenue 23.1 10.8 12.3
Cost of goods (8.0) (4.3) (3.7)
Gross profit 15.1 6.5 8.6
Sales and marketing (104.7)* (13.5) (91.2)
Research & development (46.2) (46.8) 0.6
Administrative expenditure (15.7) (13.7) (2.0)
Other gains - 1.1 (1.1)
Operating loss (151.5) (66.4) (85.1)
Finance income net 6.0 3.5 2.5
Share of profit of jointventure 0.6 0.1 0.5
Loss before tax (144.9) (62.8) (82.1)
Taxation 7.5 12.8 (5.3)
Loss for the financial year (137.4) (50.0) (87.4)
* Includes £74.5m allergy franchise goodwill impairment
40
Research & developmentYear ended 31 December 2016
H2 allergy expenditure £5.3m limited to three areas
– Completion of house dust mite allergy field study
– Drug product and stability programs
– Committed costs including cat allergy two-year follow-up
Remaining allergy expenditure in 2017 ~£6m
Respiratory programs
– Seriveo® and Spiriva® substitute programs
Non-allergy R&D £20.5m (inc £2.0m amortization)
Impairment and provisions
– Impairment of allergy licences and patents
– Production termination for cat, HDM & grass allergy programs
– UK restructuring and provisions for closure of Solna site
2016 2015 Change
£m £m £m
Allergy 19.1 30.5 (11.4)
Respiratory 6.9 6.1 0.8
NIOX 5.3 2.0 3.3
Costs not specific toprojects 11.0 8.2 2.8
Underlying R&D costs 42.3 46.8 (4.5)
Allergy contractterminations 2.4 - 2.4
Intangible assetimpairment 0.3 - 0.3
Restructuring costs 1.2 - 1.2
Total R&D costs 46.2 46.8 (0.6)
41Summary and outlook
Cost reduction
– Immediate halting of allergy investment (£19.1m in 2016)
– Consolidation of Chicago, Solna and Oxford facilities expected annual costs savings ~£6m
Collaboration with AstraZeneca
– Commercial infrastructure investment crucial to attracting AstraZeneca
– Focus on increasing field force to 200
– Expect some disruption in Tudorza® and NIOX® sales in 2017
– Expense most of $62.5m collaboration R&D contribution in 2017
– Payment of $17.5m R&D costs to AstraZeneca December 2017
– Anticipate earnings enhancing after 1 year, broadly cashflow neutral for 3 years then cash generative
Well positioned with robust balance sheet
– Focus on AstraZeneca collaboration to grow sales of Tudorza®
– Progress broader respiratory portfolio; continue investment in earlier-stage new products
42
NIOX® asthma management
AstraZeneca partnership
Respiratory pipeline
1
2
3
SPIRE allergy therapies4
Summary6
Financial results5
43
Building world-class specialty pharma business
− Robust infrastructure established for specialty and direct substitute product commercialisation
− NIOX® revenues increasing strongly
− Collaboration with AstraZeneca brings Tudorza® and Duaklir®
Strong and balanced growth platform
− Commercial platform expanded as growth engine
− Respiratory pipeline broadened with addition of three new COPD programmes
− Allergy investment curtailed with broader focus on cost containment
− Robust balance sheet and funded to deliver (£117.4m cash at 31 December 2016)
Good progress despite allergy set back
Contact us
Office Investors Financial and CorporateCommunications
CircassiaNorthbrook HouseRobert Robinson AvenueOxford Science ParkOxford OX4 4GAUnited Kingdom
W: www.circassia.comE: [email protected]
Steven Harris, CEOJulien Cotta, CFO
T: +44 (0) 1865 405560
FTI Consulting200 AldersgateAldersgate StreetLondon EC1A 4HDUnited Kingdom
T: +44 (0) 20 3727 1000E: [email protected]