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Prediction of microscale droplet instability in concentrated emulsion Davis Hoffman [1] Department of Mechanical Engineering MOTIVATION Microfluidics plays an important role in techniques for screening in biochemistry. Screening throughput limited by hydrodynamic instability of droplets. Stability of droplet entering microchannel currently classified using 2 features [1]. Machine learning useful for building classification model in the bistable region. METHODS Baseline: image feature extraction preprocess extraction Feature vector, = 12 13 14 15 12 13 14 15 1 2 1 2 1 2 With features and labels defined, any supervised learning algorithm may be applied Deep learning: convolutional and non-convolutional REFERENCES [1] W. Khor, M. Kim, S. Schütz, T. Schneider, and S. K. Y. Tang. “Time-varying droplet configuration determines break-up probability of drops within a concentrated emulsion”, Applied Physics Letters, 111, 124102, 2017. BASELINE RESULTS DEEP LEARNING RESULTS CONCLUSIONS - Transfer learning using pretrained MNIST classifier - 660 droplet images with class imbalance of 57% Simple NN ConvNet Droplet stability classifiers developed using broad variety of approaches Important features identified using decision trees. Prevalent droplet configurations assessed using k-means clustering. [1] Thank you to Professor Sindy Tang, Neal Jean, Jian Wei Khor, and Ya Gai for providing data and feedback through the duration of the project. Log. Reg GDA SVM RF Accuracy (%) 70.2 68.6 86.8 86.2 Classifier performance on feature extraction: Clustering on extracted features to group similar droplet configurations. Simple NN ConvNet Accuracy (%) 81.7 89.9 Found pattern in droplet skewness Found unfavorable packing pattern Variable feature importance from random forest Features associated with leading droplets are most important Unstable Stable Cluster 1 Cluster 2 Other features are not negligible (could add more features by including more droplets in frame) MNIST weights

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Prediction of microscale droplet instability in concentrated emulsionDavis Hoffman[1]

Department of Mechanical Engineering

MOTIVATION• Microfluidics plays an important role in techniques for screening in

biochemistry.• Screening throughput limited by hydrodynamic instability of droplets.• Stability of droplet entering microchannel currently classified using 2

features [1].

• Machine learning useful for building classification model in the bistableregion.

METHODS• Baseline: image feature extraction

preprocess extraction

Feature vector, 𝑥 =

∆𝑥12∆𝑥13∆𝑥14∆𝑥15∆𝑦12∆𝑦13∆𝑦14∆𝑦15𝑎1𝑎2𝑏1𝑏2𝜃1𝜃2

With features and labels defined, any supervised learning algorithm may be applied

• Deep learning: convolutional and non-convolutional

REFERENCES[1] W. Khor, M. Kim, S. Schütz, T. Schneider, and S. K. Y. Tang. “Time-varying

droplet configuration determines break-up probability of drops within a concentrated emulsion”, Applied Physics Letters, 111, 124102, 2017.

BASELINE RESULTS DEEP LEARNING RESULTS

CONCLUSIONS

- Transfer learning using pretrained MNIST classifier- 660 droplet images with class imbalance of 57%

Simple NN

ConvNet

• Droplet stability classifiers developed using broad variety of approaches• Important features identified using decision trees.• Prevalent droplet configurations assessed using k-means clustering.

[1]Thank you to Professor Sindy Tang, Neal Jean, Jian Wei Khor, and Ya Gai for providing data and feedback through the duration of the project.

Log. Reg GDA SVM RF

Accuracy (%) 70.2 68.6 86.8 86.2

• Classifier performance on feature extraction:

• Clustering on extracted features to group similar droplet configurations.

Simple NN ConvNet

Accuracy (%) 81.7 89.9

Found pattern in droplet skewness Found unfavorable packing pattern

• Variable feature importance from random forest

Features associated with leading droplets are most important

Unstable Stable

Cluster 1 Cluster 2

Other features are not negligible (could add more features by including more droplets in frame)

MNIST weights