Practice Test #2 | Pharmaceutical Chemistry-II (Organic)

Practice Test #2 | PharmaceuticalChemistry-II (Organic)

Summary This is practice test no. 2 in pharmaceutical chemistry test series.Thispractice test includes objective questions (MCQs) from pharmaceutical organic

chemistry (pharma chemistry 2) for D.Pharma and B.pharma students

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This is practice test no. 2 in pharmaceutical chemistry test series.This practice test includes objective questions (MCQs) from pharmaceuticalorganic chemistry (pharma chemistry 2) for D.Pharma and B.pharmastudents. These questions are very helpful for competitive as well as(objective questions based) university exams.

1. Commonly used amide type of local anesthetic agent is

A. ProcaineB. BenzocaineC. AmethocaineD. Lignocaine

Answer:


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(D) Lignocaine Explanation: Lignocaine is most commonly used anesthetic. It iscommonly known as xylocaine and its belongs to amide class.

2. Adrenaline (vasoconstrictor) is used with procaine hydrochloride injection to -

A. Increase the activity of procaineB. Prolong the duration of anesthetic actionC. Reduce the toxicityD. None of the above

Answer: (B) Prolong the duration of anesthetic action Explanation: Adrenaline is a adrenergic drug, causes vasoconstriction sodecrease area of absorption of drug.

3. Mogadone, hypnotic drug is brand name of -

A. LorazepamB. NitrazepamC. MethaqualoneD. None of the above












Answer: (B) Nitrazepam Explanation: Nitrazepam is a hypnotic drug under benzodiazepines class isavailable in the market under the brand name of mogadone, nitravet,sedamon, hypnotext etc. it is used for treatment of insomnia (sleepingdesorder).

4. which one of these is not true for pilocarpine?

A. It is naturally occuring alkaloidB. Used for teatment of glaucomaC. It is a cholinergic antagonistD. It contains imidazole nucleus

Answer: (C) It is a cholinergic antagonist Explanation: Pilocarpine is not a cholinergic antagonist.

5. Pseudoephedrine differs from ephedrine in -

A. Chemical structureB. IsomerismC. ActivityD. Activity and isomerism

Answer: (D) Activity and isomerism Explanation: Pseudoephedrine is a diasteromer of of ephedrine. Theactivity us also different from ephedrine.












6. Digoxin contains hydroxyl groups at position-

A. 3 and 12B. 3 and 14C. 3, 12 and 14D. 3, 12 and 15

Answer: (C) 3, 12 and 14 Explanation: Digoxin has 3 hydroxyl groups in the steroidal nucleus at 3,12 and 14 positions.

7. Lasix is the common brand name for

A. FurosemideB. Ethacrynic acidC. SprinolactoneD. Hydrochlorthiazide

Answer: (A) Furosemide Explanation: Furosemide is a loop diuretic (ceiling diuretics) and availableunder the brand names lasix, furid, frumex, etc.

8. Which one of these contain benzhydryl group?

A. HistamineB. DiphenhydramineC. Dimenhydrinate












D. Both option (b) and (c)

Answer: (D) Both option (b) and (c) Explanation: Diphenhydramine and dimenhydrinate both containbenzhydryl group. (Below is the image showing the structure ofdiphenhydramine HCl containing benzhydryl group.)

9. The piperidine ring skeleton is present in

A. PantazocineB. LevorphanC. PethidineD. Nalorphine

Answer: (C) Pethidine Explanation: Pethidine (mepridine) is a synthetic opioid analgesic ofpiperidine class.

10. Paracetamol is marketed as -

A. TylenolB. CalpolC. CrocinD. All of the above

Answer: (D) All of the above Explanation: Paracetamol (acetaminophen) is available under the brandnames tylenol, calpol, Crocin, PCM, dolo etc.












11. Which drug has the antiserotonin activity?

A. CyproheptadineB. PromethazineC. TerfinadineD. All of the above

Answer: (A) Cyproheptadine Explanation: Cyproheptadine (periactin, peritol, etc.) is an antihistaminicwith additional anti cholinergic , antiserotonergic, and local anestheticproperties.

12. Which is the non acidic anti-inflammatory agent?

A. OxyphenbutazoneB. IbuprofenC. PiroxicamD. Nabumetone

Answer: (D) Nabumetone Explanation: Nabumetone is a nonacidic NSAID prodrug that is rapidlymetabolized in the liver to the active metabolite, 6-methoxy-2-naphthylacetic acid. It is available with the brand name nabuflam.

13. Which one of these antitubercular drugs contain pyridine nucleus?












A. IsoniazidB. PyrizinamideC. EthionamideD. Cycloserine

Answer: (C) Ethionamide Explanation: Ethionamide contains pyridine nucleus.

14. Erythromycin will be unstable at pH

A. 8B. 9C. 4D. None of the above

Answer: (C) 4 Explanation: Erythromycin is unstable in acidic medium (pH

15. The chemical name for metronidazole is

A. 2-methyl-5- nitro-1H-imidazole-1-ethanolB. 2-methyl- 5-nitro-1H-imidazole-1-methanolC. 2-methyl-5-nitro-2H-imidazole-1-ethanolD. 2-methyl-5-nitro-1H-imidazole-1- methanol












Answer: (A) 2-methyl-5- nitro-1H-imidazole-1-ethanol Explanation: Metronidazole is 2-methyl-5- nitro-1H-imidazole-1-ethanolandit is antibacterial and antiprotozoal agent. Brand name - flagyl

16. The clofibrate is used in -

A. type iii hyperlipoproteinemiaB. HypertensionC. vascular problemsD. Raynauds disease

Answer: (A) type iii hyperlipoproteinemia Explanation: Clofibrate is a lipid lowering agent indicated inhyperlipoproteinemia (type III).

17. Which of these has azocinyl moiety?

A. GuanethidineB. ClofibrateC. QuinidineD. Quinine

Answer: (A) Guanethidine Explanation: Guanethidine is an antihypertensive drug. It has azocinylmoiety in its structure.












18. The muscle relaxant 'meprobamate' is a derivative of -

A. DicarbamateB. Dioic acidC. DiamineD. Diol

Answer: (A) Dicarbamate Explanation: Meprobamate is dicarbamate. it is used as skeletal musclerelaxant.

19. Which one of these is not a mydriatic agent?

A. AtropineB. HomatropineC. TropicamideD. Hyoscyamine

Answer: (D) Hyoscyamine Explanation: Hyoscyamine is not a mydriatic agent. Mydriatic agents aredrugs which can dilate the pupil of eye. Atropine, homatropine, tropicamideare tropane alkaloids and mydriatic agents. Hyoscyamine is also a tropanealkaloid but it is not a mydriatic agent.

20. The chemical name 1,1-oxybisethane belongs to -

A. Dimethyl ether












B. Diethyl etherC. Methyl ethyl etherD. Cyclopropyl ether

Answer: (B) Diethyl ether Explanation: Diethyl ether is ethoxy ether or 3-oxapentane or 1,1-oxybisethane.

21. The pentothal sodium is a -

A. Local anestheticB. Intravenous anestheticC. General anestheticD. Hypnotic

Answer: (B) Intravenous anesthetic Explanation: Pentothal sodium (thiopental sodium) is a short actingbarbiturates and used as Intravenous (i.v.) Anesthetic agents.

22. The prefix 'sila' is used for

A. SulphurB. SiliconC. SeleniumD. None of the above

Answer: (B) Silicon Explanation: Silicon is represented by the prefix 'sila'.












23. Which one of these sulpha drug possess guanidine, used in bacillary dysentery?

A. SulphadiazineB. SulphadimidineC. SulphaguanidineD. Sulphasomidine

Answer: (C) Sulphaguanidine Explanation: Sulphaguanidine is used in bacillary dysentery. It is aveterinary drug.

24. The basic ring present in estradiol (female sex hormone) -

A. 5 α - androstaneB. 5 α - estraneC. 5 α - pregnaneD. None of the above

Answer: (B) 5 α - estrane Explanation: The basic steroidal ring in estradiol is 5 α - estrane.

25. Two polypeptide chain in insulin is linked together by -

A. Hydrogen bondB. Disulphide bondC. Covalent bond












D. None of the above

Answer: (B) Disulphide bond Explanation: Insulin is a dimer of an A- chain and a B- chain, which arelinked together by disulphide bond.

26. Acetazolamide, carbonic anhydrase inhibitor, is used in

A. GlaucomaB. HypertensionC. Bacterial infectionD. None of the above

Answer: (A) Glaucoma Explanation: Acetazolamide (diamox) is used in glaucoma to reduce intra-ocular pressure.

27. One of the anti-rheumatic drug owes its activity due to its sulphide metabolites -

A. IndomethacinB. SulindacC. KetoprofenD. None of the above

Answer: (B) Sulindac Explanation: Sulindac is related to indomethacin and has good anti-inflammatory action due to its sulphide metabolites.












28. Which one of these drug is a tricyclic antidepressant drug?

A. TranylcypromineB. PhenelzineC. IsocarboxazideD. Trimipramine

Answer: (D) Trimipramine Explanation: Imipramine, chlopramine and trimipramine are Tricyclicantidepressant (TCA) drugs.

29. Aminophylline is salt of ethylenediamine with -

A. TheophyllineB. CaffeineC. TheobromineD. None of the above

Answer: (A) Theophylline Explanation: Aminophylline is a compound of theophylline and ethylene diamine in 2:1 ratio. It is a bronchodilator containing 2 parts of theophyllineand 1 part of ethylene di amine.

30. The diagnostic agent propyliodone is used for -

A. UrographyB. Bronchography












C. ArteriographyD. Myelography

Answer: (B) Bronchography Explanation: Propyliodone (Dionosil) is used as contrast media inbronchography.

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Practice Test #2 | Pharmaceutical Chemistry-II (Organic)