However, telomeres also play other important roles in cell
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Lets review DNA replication
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End of replication problem
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Telomerase
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How telomerase work
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Telomerase in humans Telomerase presents with high level in
various proliferative cells Stem cells Activated lymphocytes Hair
follicles Cancer cells Etc.
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Telomerase in humans Telomerase presents with detectable level
in some adult cells Epithelial Fibroblast Endothelial Etc.
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Protective function Chan and Blackburn, 2003
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Telomerase in cancer cell cancer cell
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Telomerase in cancer cell
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This event certainly require telomerase
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Telomerase in cancer cell Li et al. 2004; Bagheri et al
2006
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the high levels of telomerase promote an undifferentiated,
stem-cell-like phonotype Other experiments support that
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Knock-down of telomerase inhibits metastasis in vivo mouse
melanoma model Kashani-Sabet et al, 2004
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Telomerase and Aging Cawthon et al, 2003
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Telomerase and Aging Cawthon et al, 2003 Shorter telomeres 3.2
fold higher mortality rate from heart disease 8.5 fold higher
mortality rate from infectious disease
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Chronic stress and telomere Blackburn et al, 2004
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As lots of researches suggested that telomere plays important
role in cancer and aging, telomere is expected to be the effective
target for drug involving aging and cancer.
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Reference Gerald carp, Cell Biology,6th edition, Wiley.
Elizabeth Blackburn, Lecture on telomerase part1-3. www.youtube.com
http://www.pharmacy.ubc.ca/faculty_staff/facultysites/jwonglab
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1544082/ Li et al.
Genes and pathways downstream of telomerase in melanoma metastasis,
2004. Chan, S. W.-L and Blackburn, E.H. Telomerase and ATM/Tel1p
protect telomeres from nonhomologous end joining., 2003