PRABHAVA
WELCOME
Please occupy your seats 1
Good Afternoon2
Ayurveda- Compendium of Wisdom
Authentic concepts & theories
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Acquired knowledge
Traditional
Academic- Samhitas, Commentaries
Practical
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Is this knowledge enough???
Do we have to explore & revive the intricacies of the basic
knowledge we possess..5
Do question, even the basics!You will be a fool for once!If you
don't, you will be, for a lifetime.. Himmilicious
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Reviving the concept ofPrabhava
Department of DravyagunavijnanaVPSV Ayurveda
College,Kottakkal
Dr. Praseetha P G Dr.N.Manojkumar I MD ScholarReader
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Contents of Discussion
Review of Prabhava
Reanalyzing Prabhava
Reviving Prabhava
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Prabhava- A Review
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Origin of the conceptDefining PrabhavaConcept in
detailAuthenticityImportance of Prabhava
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Human-The Supreme ExplorerFirst Physician wandered in Jungle
Critical Observations
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Discovery of Dravya
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(.../)
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DRAVYARasaGunaVeerya VipakaPrabhava15
Prabhava + +
() :
: I()
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More PowerfullDominantExcellingDistinguished17
Other contextsVedas & Puranas
PowerInfluenceManifestationOf material existence18
Defining Prabhava
I : :II(.-)
I()
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: :(..-)
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Concept of Prabhava
: : : :()
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Various terminologies ()
: :(.-)22
: : I II(.-)
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Different interpretation Cakrapani: Veerya- Chintya sakthi
Achintya sakthi
Prabhava24
Is it a final word????...Or a clue to something more..
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Passing time & changing theoriesHallmark of many systems of
medicine
Certain levels of uncertainty
What to believe? What to forget ?
Approximate or Accurate?26
Ayurveda- The Eternal ScienceTime tested science of life
Time-tested theories
Accept defeat rather than fake win
Reasoning beyond ones logic
Prabhava
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: : I II (..-)
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Importance of
PrabhavaAcintyaDaivapratighataVisapratighataDarsanatSravanatTulyarsagunesu
VisesataAdhbuta KarmaAgama29
Prabhava- A Re-analysis
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Re-analysis of the ExamplesDrug ResearchesSite specificity of
DrugsYoga Prabhava
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Prabhavaja KarmasAushadikarma - PharmacologicalAgadiyakarma
Toxic & AntitoxicRakshoghnakarma- AntimicrobialBhautikakarma
Physical Manasakarma -
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Virecana karma of Danti
Danti & Chitraka
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Anthraquinines & Carbohydrates
Pharmacognostic Studies on the Roots of Baliospermum Raziana
keshav Et Yog. G.V.R. Joseph , CCRAS,Kerala
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Virecana karma of Draksha
Draksha & Madhuyashti
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Medhya KarmaSankhupushpi BrahmiGuduciMadhuyashti
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Tikta RasaT2Rs- T2R4, T2R107 and T2R38 expressed in multiple
regions of the rat brain-brain stem, cerebellum, cortex and nucleus
accumbens. Functional bitter taste receptors are expressed in brain
cells.Singh N, Vrontakis M, Parkinson F, Chelikani P
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Sweet Taste
The heterodimeric sweet taste receptor has multiple potential
ligand binding sites.Cui M et.al, Mount Sinai School of
Medicine,Newyork
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Visaghna karma of Sireesa
Universal Antidote
Multitude of Poisons40
Rakshoghna karma
Anti-microbial activity
Antimicrobial Activity of Clitoria ternatea (L.) Extracts L.
Kamilla et.al
In vitro assessment of potenial of Commiphora whighti(Arn) gum
extract Kalpesh.B et.alon41
Salyaharana KarmaMagnetism42
Manidharana & MantrasPsychologicalColourVibrationsAsterism
& ChatoyancyRendering gems with aterism or chatoyancy S Yokoi,
K Kurashige, J Toriwaki - The Visual Computer, 1986 Springer
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Site Specificity Is it Prabhava ?44
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Asoka- Saraca asoca
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Garbhasaya RasayanaActive principles- one stimulating and the
other relaxing
Stimulate the uterus, making the contraction more frequent and
prolonged.
Crystalline glycoside stimulate uterine contraction
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Oxytocic activity of a pure phenolic glycoside (P2) from Saraca
indica Linn (Ashoka): a short communication. Satyavati GV et al
Ashoka (Saraca indica) increase estrogen levels and normalize the
endometrium during menstruation (The Antiseptic, Vol.95, October
1998, p.329).
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Arjuna- Terminalia arjuna
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Mechanistic clues in cardioprotective effect of Terminalia
arjuna bark extract in isoprotrenol -induced chronic heart failure
in rats.Parveen A, Babbar R, Agarwal S, Kotwani ADepartment of
Physiology, Maulana Azad Medical College, University of Delhi,
India
Antianginal and cardioprotective effects of Terminalia arjuna,
an indigenous drug, in coronary artery disease.Dwivedi S, Agarwal
MP.Department of Medicine, UCMS, Delhi
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Yoga Prabhava
Sahacaradi KashayamPrasaranyadi KashayamPathyakshadhatryadi
Kashayam
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?Deepanakarma of Ghrtha
Pumsavana
Sadya sukrakarana
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Reviving Prabhava
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Proposed TheoriesInterpreting PrabhavaConclusion
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Isomerism
Active constituents
Receptor-Effector Theory54
Isomerism55
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Receptor- Effector TheoryReceptor: Macromolecule/ Binding site
on or inside effector cellTo recognise the signal molecule/
drugInitiate response57
Lock & Key mechanism
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TypesType 1 : Channel-linkedType 2 : G-protien-coupledType 3 :
Kinase-linkedType 4 : Gene transcription60
Channel linked
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G-protein-coupled
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Kinase-linked
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Gene transcription regulators
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Induced FitA situation where the receptor changes shape as it
binds to a ligand so that its binding site more closely conforms to
the shape of the ligand.66
Active Chemical ConstituentsThat performs the intended chemistry
or biochemisrtyInducing specific response67
Affinity
Potency
Efficacy68
I (.-)
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ConclusionIndication for further Research
Substitution
Use of single drugs
Identification of specific chemical constituents71
What is known is a drop of knowledge
What is unknown is a deep ocean
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ReferenceRendering gems with aterism or chatoyancy S Yokoi, K
Kurashige, J Toriwaki - The Visual Computer, 1986 Springer
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