POTENTIAL USE FOR THE ANTIDEPRESSANT, TRAZODONE, IN ACUTE STROKE Results of a pilot study suggest trazodone may be beneficial in patients suffering acute stroke. Trazodone was administered intravenously (lOmg bid for 7 days) to 21 patients with acute stroke, and the results were compared with those in a similar group given dexamethasorre, ma.-..nitcl, :md papaverine. Therapy was started upon admission to hospital, which was usually within a few hours of onset of the attack. Trazodone appeared to have a significant effect on orientation, recent recall, - motor function, and aphasia. The period of hospitalisation was shorter for the trazodone patients (mean, 16d) than for control patients (26d). Mortality rates were not significantly different for the 2 groups. The authors caution that these results should be considered as only preliminary because of the small number of patients and because of the lack of standardisation of therapy in the control group. Nevertheless, the results warrant further investigation of trazodone in acute stroke. Trazodone, an antidepressant, was tried in the treatment of acute stroke because of its antiserotonin properties. Anti- serotonin agents may be useful in stroke because the adverse sequelae of stroke depend not only on the extent of the ischaernic·area but also on a number of factors influenced by serotonin. Moreover, trazodone may reduce cerebrospinal fluid pressure. Allori, L. et al.: Current Medical Research 18: 410 (Sep i975) INPHARMA4th October,1975p.10

POTENTIAL USE FOR THE ANTIDEPRESSANT, TRAZODONE, IN ACUTE STROKE

Download PDF Report

Upload
phamphuc
View
212
Download
0

Embed Size (px)

Citation preview

POTENTIAL USE FOR THE ANTIDEPRESSANT, TRAZODONE, IN ACUTE STROKE

Results of a pilot study suggest trazodone may be beneficial in patients suffering acute stroke. Trazodone was administered intravenously (lOmg bid for 7 days) to 21 patients with acute stroke, and the results were compared with those in a similar group given dexamethasorre, ma.-..nitcl, :md papaverine. Therapy was started upon admission to hospital, which was usually within a few hours of onset of the attack. Trazodone appeared to have a significant effect on orientation, recent recall, -motor function, and aphasia. The period of hospitalisation was shorter for the trazodone patients (mean, 16d) than for control patients (26d). Mortality rates were not significantly different for the 2 groups.

The authors caution that these results should be considered as only preliminary because of the small number of patients and because of the lack of standardisation of therapy in the control group. Nevertheless, the results warrant further investigation of trazodone in acute stroke.

Trazodone, an antidepressant, was tried in the treatment of acute stroke because of its antiserotonin properties. Antiserotonin agents may be useful in stroke because the adverse sequelae of stroke depend not only on the extent of the ischaernic·area but also on a number of factors influenced by serotonin. Moreover, trazodone may reduce cerebrospinal fluid pressure.

Allori, L. et al.: Current Medical Research 18: 410 (Sep i975)

INPHARMA4th October,1975p.10