Agilent’s

Portfolio for

Food Safety

Ruby OngMarketing Program Manager

Chemical Analysis Group

SAPK

A Heritage of Innovation: Varian & Agilent

“The acquisition will establish Agilent as a clear market leader in analytical solutions and give us the talent and technology base for creating unique new products and markets.”

- Bill Sullivan, President and CEO, Agilent Technologies

Today’s Agilent

Today’s Agilent offers the broadest product portfolio in the industry and a robust and diverse pipeline to continually feed our customers’ quest for scientific innovation.

Food Testing and AgricultureEnergy and Fuels EnvironmentalForensics and Drug TestingMaterials Science, Specialty ChemicalsPharmaceutical and Biopharmaceutical Clinical Diagnostics & ResearchGenomics, Metabolomics, Protein StudiesVacuum Solutions

Agilent Product Portfolio for Food Applications

Product Categories include –

Gas Chromatography (GC)

Liquid Chromatography (LC)

Gel Permeation Chromatography (GPC)

Mass Spectrometry (GCMS, GC-QQQ, etc.)

Atomic Spectroscopy (AAS, ICP-OES, ICPMS)

Molecular Spectroscopy (FTIR, UV-Vis)

Dissolution

Consumables and Supplies

And many more……

Food Applications

Food Safety

- Contaminants and Residues

- Pesticides / Herbicides Residues

- Antioxidants and Mycotoxins

- Preservatives and Additives

- Allergens

- Organic Residues (Dioxin, Melamine, PCB etc)

- Illegal Dyes

- Veterinary Residues

- Heavy Metals

Nutritional Labeling

- Vitamins and Minerals

Food Authenticity

- Halal Verification

- Organic Foods

Regulatory Bodies (Food)

Malaysia Food Act 1983 & Food

Regulation 1985

US Food Drug Administration

(FDA)

Agri-Food and Veterinary

Authority of Singapore

Japan Food Safety Commission

Agilent’s Gas Chromatography

Instrumentation Food

Gas Chromatography

Direct Injection of Fish Oil for the GC-

ECD Analysis of PCBs

Analysis of Preservative Additives in

Food

Analysis of Fusel Oils

Agilent’s GCMS, GCMS/MS and Ion Trap

Instrumentation Food

GCMS and GCMS/MS

Trace-Level Analysis of Melamine in Milk Products using GCMS

Rapid Screening and Confirmation of Melamine and its Analogs in Baby Formula and Soy Products using GCMS/MS

GCMS Approaches to the Analysis of Acrylamide in Foods

GC with Low Thermal Mass (LTM) Technology

Agilent’s Liquid Chromatography

Instrumentation Food

HPLC

Quantitative Liquid Chromatography Analysis of Melaminein Diary Products using Agilent's 1120 Compact LC and 1200 RRLC

Determination of Acrylamide in Cooking Oil

Ultrafast analysis of synthetic antioxidants in vegetable oils using the Agilent 1290 Infinity LC system

Agilent’s LCMS (TOF, Ion Trap, Triple Quadrupole,

Q-TOF)

Instrumentation Food

LCMS

Rapid Screening and Confirmation of

Melamine in Milk and Its Products by LCMS

A Low Femtogram Target Screen Method for

Perfluorinated Compounds in Food Matrices

and Potable Water using Triple Quadrupole

LCMS

LC-TOFMS As a Tool to Support Can

Coating/Food Interaction Studies

Agilent’s Atomic Spectroscopy (ICPMS, ICP-OES,

AAS)

Instrumentation Food

Atomic Spectroscopy

(ICPMS, ICP-OES, AAS)

Determination of Trace Metals in

Food, Trace Metals in Edible Oil

Determination of Isotope Ratios in

Elements provided as Trace

Element Supplements

Measuring Metals in Proteins to

monitor Elemental Absorption from

the Diet

Agilent’s Molecular Spectroscopy (FTIR)

Instrumentation Food

Molecular

Spectroscopy

(FTIR)

Food Adulteration by FTIR

Fats and Oils, Alcoholic Beverages by

FTIR

Agilent’s Nuclear Magnetic Resonance (NMR)

Instrumentation Food

NMR

Determination of Solid Fat Content or Ingredient Purity

Composition Studies of Food Ingredients / Fresh Vegetable Tissue

Studies of the effects of Processing on Food Properties and Quality

Agilent Consumables and Supplies

Agilent’s Analyzers

Agilent’s Analyzers

• GxP or ISO/IEC 17025 requirements - proof of Instrumentation is

suitable for intended use, proof of calibration and maintenance, proof of data quality

Agilent Services and Support

• Predictable cost of ownership, all inclusive Service package

• Instrument Qualification service (IQOQ, FVS)

• Maintenance service

• Training (classroom and onsite)

• Consultancy

Today’s Quality Standards are Demanding and

Increasing Importance on Food safety

Agilent is uniquely positioned to forge

the swiftest path toward new food safety applications

Each year worldwide:

• Tens of millions of food-borne

illness cases

• Hundreds of thousands

hospitalized

• Thousands of lives lost

• Hundreds of billions (money)

lost to food-borne illnesses

Why?

• Globalization

• Aging populations

• Pathogens entering the

food supply in new ways

Opportunity: The demand for applications is growing significantly faster in the foodtesting industry than in any other segment

Agilent will be the first to harvest

new food testing applications. Here’s why.

Uniting the chemical and biological components of food safety testing

• An established leader in chemical testing applications

• An emerging leader in biological testing space

Deeply integrating customers into our application-development pipeline

• Knowledgeable sales force with close customer ties

• Agilent-sponsored lab-bench to lab-bench collaboration

• Local marketing resources such as people/research facilities localized

throughout major geographic regions tied together through technology

We were succeeding with customer collaborations decades before they became trendy

Agilent’s

Lab-bench to Lab-bench

Market Development Model

Create local research/technical

development teams in Europe,

the Americas, China, and India

Identify key chemical and biological

applications (unmet needs)

Collaborate with respected researchers

to make these applications a reality

Support researchers world wide on

specific applications

Communicate our findings worldwide

Commercialize successful applications

Agilent exclusive technologies

dedicated to Food Safety Applications

Mass Code PCR reagents:

highly multiplexed PCR techniques

made possible by MS detection

GC/Q-TOF technologies: extend

Agilent’s high-resolution accurate

mass TOF technologies to GC

PCR/RFLP species identification:

rapid, simple technique for food

sample speciation

Evolution and application of

existing technologies to the analysis

of pesticides, veterinary drugs,

mycotoxins, dioxins, trace metals,

allergens and other categories

Biological New Capability

Biological In-depth Solutions

We make sample preparation cleaner, faster, and simpler with:

• High-performance auto-samplers and integrated systemsthat process more samples, faster

• SPE products that extract and concentrate samples from complex matrices

• A complete range of columns, supplies and reagents

Sample Preparation and Automation

By pinpointing emerging application needs

Agilent will…

Become the #1 global

leader in food safety,

species identification

and traceability technologies

Achieve double-digit revenue

growth from commercialized

food applications by…

• Maintaining existing applications

• Forging new applications with

respected researchers worldwide

As the food industry’s premier measurement company, we will help our customers ensure the safety of the global food supply

What critical Chemical and Biological

Food Safety application areas have

our customers asked us to focus on?

Existing Core Chemical Applications GC/MS, LC/MS, GC/QQQ, LC/QQQ, LC/Q-TOF, LC/TOF, ICP/MS

Veterinary drugs

• Identification/quantification of antibiotics, steroids, and

other growth hormones

The challenge: increase speed and sensitivity while decreasing cost

Pesticides

• Quantification of known pesticides

• Identification/quantification of new pesticides and metabolites

Trace metals

• Identification/quantification of elements such as lead and mercury

Emerging Chemical Applications

Steroid hormones (difficult to measure through conventional techniques)

• GC/QQQ – Dramatic success in 2010 Winter Olympics

Mycotoxins (over 300 known; immediate toxic effects)

• Typically LC/MS

Dioxins in food (traditionally requires high-res equipment/specialized skills)

• GC/QQQ – Fast, simple, more sensitive than conventional GC approaches

Marine toxins (small-molecule compounds produced by shellfish)

• LC/QQQ (quantification of known targets)

• LC/TOF (discovery of unknowns)

Allergens (chemical aspects to identification)

• LC/MS, LC/Q-TOF, GC/QQQ – Small-molecule allergens

Emerging Biological Applications

Species identification (accidental contamination vs. intentional fraud)

• PCR, bioanalyzer, specialty bioreagents – Identify biological compounds at the

DNA level; Manipulate genetic information

Allergens (biological aspects to identification)

• LC/MS, LC/Q-TOF – Intact protein discovery with bio-confirm software

can determine the exact sequence of molecule in question

• Measurement by biological reagents

Pathogen identification (serotype)

• Mass Codes PCR with MS detection

• Identification at the DNA level

• DNA manipulation

• Tag and recognize dangerous bacteria

• Serotype determination – At what point in manufacturing process is

contamination taking place?

We’ve talked about

lab-bench to lab-bench

collaboration

Now, here’s what Agilent

brings to the bench

We bring:

Supporting research efforts with:

• Hardware/software

• Supplies/consumables/reagents

• Expertise/training/services

Communicating findings to respected leaders worldwide through:

• Peer-reviewed publications

• Technical seminars/workshops/webinars

• Individual consultations

To solve the toughest problems,

we will partner with some of the world’s best sites:

Multi-application sites

• Sites with enough bandwidth to research

multiple facets of the food industry at the

same time

• Tackle multiple problems simultaneously

Single-application sites

• Global leaders and emerging researchers

in specific application areas

Global food industry organizations

Major laboratories

Leading government agencies

Prestigious universities

Only Agilent has the chemical and biological

technology/measurement capabilities to support

a comprehensive food safety program

Only Agilent is prepared to put time, money, and talent toward finding and developing new

food safety applications

Only Agilent has created a collaborative

process for meeting current and future

food safety challenges