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8/3/2019 Plasma Proteins 1
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Zco{lo Ztaxm`n{
Emnmtoc ztazmtx`m{ onh {mcmkxmhmvolzcm{
Io`{oc Gfox`d LH7 ZfH
Iok}cxp ai Lmh`k`nm# ]n`ymt{`xp ai BathonFotzmt{ D`akfml`{xtp Kfozxmt 80
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Zco{lo `{ Adxo`nmh ital Kmnxt`i}emh Dcaah
8/3/2019 Plasma Proteins 1
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Zco{lo y{. {mt}l
UDK{
TDK{
c`q}`h
kmcc{
{z`n dcaah
{mzotoxm `nxa 4 zotx{
Dcaah u`xf
onx`kaoe}conx
Kcaxxmh dcaah
[mt}l
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[mzotox`an ai Kalzanmnx{
Zco{lo < Cm{{ Hmn{m
Fmloxakt`x
Zokgmh Kmcc{
Latm Hmn{m
Zcoxmcmx{ ! UDK{
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Kalzanmnx{ ai Zco{lo
Dcaah zco{lo Kan{`{x{ ai2
Uoxmt 0:-
Zco{lo Ztaxm`n{ 9,6 -
Mcmkxtacpxm{ &No' ) Kc, ?-
Axfmt kalzanmnx{2
N}xt`mnx{ &m.e. Ec}ka{m onh ol`na ok`h{ Fatlanm{ &m.e. Katx`{ac# xfptav`nm
Uo{xm{ &m.e. ]tmo
Dcaah eo{m{ &m.e. KA4# A4
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Zco{lo Ztaxm`n{
Zco{lo Ztaxm`n{2 O kalzcmv l`vx}tm xfox
`nkc}hm{ f}nhtmh{ ai ztaxm`n{
ocd}l`n ecad}c`n{
i`dt`naemn
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Zco{lo Ztaxm`n{
Lo`nxo`n`ne kacca`h a{lax`k doconkm &ocd}l`n)
D}iimt`ne zF kfonem{
Xton{zatx ai loxmt`oc{ xfta}ef dcaah &{}kf o{
uoxmt,`n{ac}dcm fatlanm{)
Onx`dah`m{ &m.e. eollo ecad}c`n{#
`ll}naecad}c`n{)
Kcaxx`ne iokxat{ &m.e. i`dt`naemn)
Onx`ztaxmo{m{
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[mzotox`an ai Zco{lo Ztaxm`n{
[ac}d`c`xp
[ocx`ne a}x
Mcmkxtazfatm{`{
@{amcmkxt`k Iak}{`ne
]{m ai onx`dah`m{
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Itokx`an{ ai Zco{lo Ztaxm`n{Itokx`an ola}nx&-) k &e!c)
Ocd}l`n{2 ocd}l`n ztm,ocd}l`n&xton{xfptmx`n)
=4 =6 ;8
=:
M?,ecad}c`n{2 xfptav`n,d`nh`ne ecad}c`n#
xton{katx`n# M?,ok`h ecpkaztaxm`n# M?,onx`xtpz{`n#M?,c`zaztaxm`n &FHC)# M?,imxaztaxm`n
4.8 8.8 4,8
M4,ecad}c`n{2 fozxaecad`n# loktaecad}c`n#kmt}cazco{l`n
9 ?: = 0
I,ecad}c`n{2 xton{imtt`n# fmlazmv`n#c`zaztaxm`n &CHC)# i`dt`naemn# K,tmokx`ym ztaxm`n#
K; onh K8 kalzanmnx{ ai xfm kalzcmlmnx
{p{xml
6.= ?8.=
9 ??
G,ecad}c`n{2 @eE# @eL# @eO# @eH# @eM ?: 4? 6 ?=
8/3/2019 Plasma Proteins 1
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Zacplatzf`{l ai Zco{lo Ztaxm`n{
Xfm ztm{mnkm ai xua at latm emnmx`k yot`onx{ ai
xfm {olm ztaxm`n.
Xfm yot`onx{ otm mnkahmh dp o {`necm cak}{.
Xfm yot`onx ozzmot{ `n ox cmo{x ?- ai xfm
zaz}cox`an.
Xfm yot`onx{ h`iimt {c`efxcp `n xfm`t ol`na ok`h
{mq}mnkm.
L`etoxm h`iimtmnxcp }nhmt mcmkxtazfatm{`{.
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Ok}xm Zfo{m Ztaxm`n{
Cmymc{ ai kmtxo`n ztaxm`n{ `nktmo{m h}t`ne ok}xm`nicolloxatp {xoxm{
Cmymc oc{a `nktmo{m
kftan`k `nicolloxatp {xoxm{
Konkmt
Mcmyox`an yotp ital =:- xa ?::: iach
Xfm{m ztaxm`n{ zcop o tacm `n dahp{ tm{zan{m
xa `nicollox`an
Mvolzcm{2 K,tmokx`ym ztaxm`n# ?,onx`xtpz{`n#
fozxaecad`n
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Foci,c`im ai Zco{lo Ztaxm`n{
Mokf ztaxm`n fo{ o kfotokxmt`{x`k foci c`im
Hmxmtl`nox`an ai foci,c`im
@{acoxm ztaxm`n, Codmc u`xf ?;?@
, Hmxmtl`nm `x{ toh`aokx`y`xp
, `nbmkx `nxa o natloc {}dbmkx
, U`xfhtou dcaah {olzcm ox yot`a}{x`lm `nxmtyoc{
Xfm x`lm iat toh`aokx`y`xp xa hmkc`nm ital `x{ zmogyoc}m xa anm foci ai `x{ zmog yoc}m
8/3/2019 Plasma Proteins 1
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La{x zco{lo ztaxm`n{ otm
ecpkaztaxm`n{
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Ocd}l`n
9: - ai xfm xaxoc zco{lo ztaxm`n{.
Cmymc yot`m{ u`xf oem ;.8,8.5 e!?::lc
?4 etol{ otm ztah}kmh ho`cp `n xfm c`ymt4= - ai xfm xaxoc ztaxm`n {pnxfm{`{ dp c`ymt#
anm foci ai xfm {mktmxmh ztaxm`n{.
90 gHo &Anm zacpzmzx`hm kfo`n# =6= O. Ok`h{) Foci,c`im ~ 4: hop{
8/3/2019 Plasma Proteins 1
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[pnxfm{`{ aiOcd}l`n
Ztmztaocd}l`n
{`enoc zmzx`hmZtaocd}l`n
fmvozmzx`hmOcd}l`n
8/3/2019 Plasma Proteins 1
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90 gHo
Ocd}l`n [xt}kx}tm
Mcc`z{a`hoc {fozm
Zotx`oc h`em{x`an u`xf ztaxmo{m xftmm halo`n{ F`efcp zacot u`xf xftmm fphtazfad`k kcmix{ On`an`k ox zF 5.8 u`xf 4: nmeox`ym kfotem{
8/3/2019 Plasma Proteins 1
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Ocd}l`n `{ tm{zan{`dcm iat 6: - ai xfmKacca`hoc ztm{{}tm
8/3/2019 Plasma Proteins 1
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O
D D
D
D
D
D
D`nh`ne ai ht}e{ xa ocd}l`n kon tm{}cx `n
ht}e,ht}e nxmtokx`an
O Donh otm xua ht}e{ xfox d`nh xa ocd}l`n
O
O
O
O
O
D
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Ko4'
Ko4' Ko4'
Ko4'
Ko4'
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Hmktmo{mh kankmnxtox`an ai ocd}l`n
@nohmq}oxm {a}tkm ai ol`na ok`h{.Locn}xt`x`an onh l}{kcm uo{x`ne.
C`ymt h`{mo{mXaxoc ztaxm`n kon dm natloc & ecad}c`n# ocd}l`n)
Eo{xta`nxm{x`noc ca{{Cmogoem ai ic}`h ital `nicolmh at h`{mo{mh l}ka{o
Tmnoc h`{mo{m
Zmnmxtox`an ai ocd}l`n xfta}ef ecalmt}c}{
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Onocd}`nml`o
Od{mnkm aiOcd}l`n ital xfm zco{lo
Totm kanh`x`an
Hmimkx `n xfm ztakm{{`ne ailTNO aiocd}l`n
O}xa{aloc tmkm{{`ym `nfmt`xonkm
Lahmtoxm mhmloKalzmn{ox`an dp {pnxfm{`{ ai axfmt zco{lo
ztaxm`n{
8/3/2019 Plasma Proteins 1
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Ztmocd}l`n
L`etoxm{ ofmoh ai ocd}l`n
Kald`nm{ u`xf
X8 &Xfptav`nm) onh X;
Tmx`nac d`nh`ne ztaxm`n [fatx foci c`im &4 Hop{)
[mn{`x`ym lotgmt ai zaat ztaxm`n
n}xt`x`an Hmktmo{mh n
Fmzox`k holoem
X`{{}m nmkta{`{
8/3/2019 Plasma Proteins 1
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?,Onx`ztaxm`no{m
Oc{a gnaun o{ ?,onx`xtpz{`n
@nf`d`x{ xtpz{`n# mco{xo{m# onh axfmt ztaxmo{m{
~=4 gHo Ecpkaztaxm`n & ;08 O.Ok`h{ u`xf ; ac`ea{okkfot`hm kfo`n{)
> 0:- ai xfm ?itokx`an ai f}lon zco{lo
Zt`nk`zoc {mt`nm ztaxmo{m `nf`d`xat
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?,Onx`ztaxm`no{m &zacplatzf`{l)
Lonp zacplatzf`k iatl{
Xfm lobat emnaxpzm `{ LL
O
ccmcm{Z
`
L
#Z
`
[
#Z
`
R
#Z
`
I
Hmi`k`mnkp kon hmymcaz o c}ne h`{mo{m&mlzfp{mlo)
@nh`y`h}oc{ u`xf RR emnaxpzm onh Z`[R
fmxmtarpeaxm{ @nh`y`h}oc{ u`xf L[ atLR emnaxpzm }{}occp nax
oiimkxmh
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X`{{}m holoem `n ?,onx`xtpz{`n
hmi`k`mnkp ' z}clanotp `nicollox`an
Cm}gakpxm{
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[lag`ne `n xaz ai ?,onx`xtpz{`n
hmi`k`mnkp
[zmk`i`k lmxf`an`nm &lmx ;=6) `{ `nyacymh `n
d`nh`ne ?,onx`xtpz{`n xa ztaxm`no{m
[lag`ne av`h`rm{ xf`{ lmxf`an`nm
Av`h`rmh kon nax `nf`d`x ztaxm`no{m{
@nh`y`h}oc{ u`xf Z`R zfmnaxpzm ox f`efmt t`{g.
8/3/2019 Plasma Proteins 1
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?,onx`xtpz{`n hmi`k`mnkp c`ymt h`{mo{m
Zacplmt`rox`an ai RR lacmk}cm{ `n xfm
mnhazco{l`k tmx`k}c}l ai fmzoxakpxm{
Oeetmeox`an `{ h}m xa `nxmtokx`an dmxummn o
caaz `n anm lacmk}cm onh o ztal`nmnx ,
zcmoxmh {fmmx `n onaxfmt lacmk}cm.
?,onx`xtpz{`n `{ nax tmcmo{mh ital kmcc{
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Caaz,{fmmx zcaplmt`rox`an
ai xfm RR lacmk}cm{
Lacmk}cm ai
xfm L
zfmnaxpzm
Ztal`nmnx ,zcmoxmh {fmmx `n
xfm R lacmk}cm{
8/3/2019 Plasma Proteins 1
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Fozxaecad`n &Fz)
4 ecpkaztaxm`n &0:gHo) [pnxfm{`rmh lo`ncp dp fmzoxakpxm{
Xua g`nh{ ai zacpzmzx`hm kfo`n{ X
ua kfo`n{ Anm kfo`n
Xftmm zacplatzf`k iatl{ Fz ?,?# Fz 4,?# Fz 4,4
Zacplatzf`{l `{ o{{ak`oxmh u`xf lonp `nicolloxatph`{mo{m{.
Ok}xm zfo{m ztaxm`n Cmymc `n o yot`mxp ai `nicolloxatp {xoxm{#
oc{a `n d}tn# nmzftax`k {pnhtalm
8/3/2019 Plasma Proteins 1
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Fozxaecad`n I}nkx`an
D`nh`ne ai itmm fmlaecad`n
?:- ai xfm Fd hmetohmh mokf hop `{ tmcmo{mh
`nxa xfm zco{lo
Fd &9= gHo) Fd2Fz Kalzcmv &?== gHo)
G`hnmp
G`hnmp ]zxogm dp c`ymt
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Fozxaecad`n cmymc
Lmo{}tmh o{ Fd d`nh`ne kozok`xp Natloccp 8:,?6: le ai Fd d`nh`ne kozok`xp
Cmymc `n fmlacpx`k onml`o
Fd,Fz kalzcmv fo{ {fatxmt foci,c`im xfon xfox ai
Fzx?!4 ai Fz = hop{
x?!4 ai Fd,Fz 0: l`n}xm{
Fd,Fz kalzcmv `{ kcmotmh 6: x`lm{ io{xmt xfon Fz
8/3/2019 Plasma Proteins 1
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?,imxaztaxm`n &OIZ)
Uo{ i`t{x h`{kaymtmh `n xfm {mt}l ai xfm imx}{.
Ymtp cau cmymc `n oh}cx.
Hmxmkxodcm `n xfm loxmtnoc dcaah `n ztmenonkp Mcmyoxmh cmymc `n {alm kanemn`xoc hmimkx{
Cau cmymc `nktmo{mh t`{g ai Haun{
{pnhtalm F`ef cmymc `n lonp ko{m{ ai c`ymt konkmt
8/3/2019 Plasma Proteins 1
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4,Loktaecad}c`n
Cotem ztaxm`n 54: gHo Xmxtolmt ai 8 `hmnx`koc kfo`n{
6,?: - ai xfm xaxoc zco{lo ztaxm`n{
[pnxfm{`rmh dp Lanakpxm{
Fmzoxakpxm{
O{xtakpxm{ Cmymc yot`m{ u`xf oem# emnhmt
@nktmo{mh cmymc `n nmzftax`k {pnhtalm
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4,Loktaecad}c`n
Zon ztaxm`no{m `nf`d`xat
Xtpz{`n# zmz{`n# zco{l`n# xftald`n
`nf`d`xat ai
Kaoe}cox`an I`dt`nacp{`{
Iatl{ kalzcmv u`xf xfm ztaxm`no{m iaccaumh dp
kcmotonkm
D`nh`ne xa lonp kpxag`nm{ &{`enoc lacmk}cm{)
onh h`tmkx`ne xfml xa xfm`t xotemx kmcc{
8/3/2019 Plasma Proteins 1
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Kmt}cazco{l`n
4,ecad}c`n &?9: gHo)
D`nh{ kazzmt
X`efx d`nh`ne
0:- ai xfm zco{lo kazzmt & 9 oxal{!lacmk}cm)
Ocd}l`n d`nh{ xfm tmlo`n`ne ?:-
Fo{ av`ho{m okx`y`xp &imttav`ho{m)
Cau cmymc `n U`c{an h`{mo{m.
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Kazzmt2 on m{{mnx`oc xtokm mcmlmnx
Ho`cp `nxogm 4,8 le
Dahp kanxo`n{ ~ ?:: le
Kaiokxat iat o n}ldmt ai mnrplm{ Kpxakftalm av`ho{m# ol`nm av`ho{m
Kon ocxmtnoxm dmxummn K}4' onh K}'
Mvkm{{ kazzmt kon dm fotli}c
Lmxoccaxf`anm`n{# o eta}z ai {locc ztaxm`n{
tme}coxm x`{{}m cmymc ai kazzmt
Kazzmt
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K,Tmokt`ym Ztaxm`n
]nhmxmkxodcm `n fmocxfp `nh`y`h}oc{ @n zox`mnx{ u`xf h`ymt{m `nicolloxatp
h`{mo{m{
Ok}xm tfm}lox`k imymt# dokxmt`oc `nimkx`an# ea}x .. X`{{}m holoem
Tmokx{ u`xf K {}d{xonkm & zacp{okkfot`hm `n
Zn}lakakk` onh lacmk}cot eta}z{ an o u`hmyot`mxp ai dokxmt`o
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Dcaah Aymty`mu
zco{lo~==- ai dcaah
F4A 04-
zco{lo ztaxm`n{ 5-`an{
n}x`tmnx{
uo{xm{
fatlanm{
8/3/2019 Plasma Proteins 1
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Dcaah zco{lo
ztaxm`n{2
ocd}l`n{
9:- ai zco{lo ztaxm`n{
lohm `n c`ymtxton{zatx2
ioxxp ok`h{
fatlanm{axfmt {x}ii
8/3/2019 Plasma Proteins 1
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Dcaah zco{lo
ztaxm`n{2
ecad}c`n{
;=- ai zco{lo ztaxm`n{
xua xpzm{`ll}naecad}c`n{
xton{zatx ecad}c`n{
ogo.# onx`dah`m{ &Od)
fatlanm,d`nh`ne &xfpta`h F)
lmxoccaoztaxm`n{ &`tan)
ozac`zaztaxm`n{ &c`z`h{)
{xmta`h,d`nh`ne &xm{xa{xmtanm)
8/3/2019 Plasma Proteins 1
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Ko}{m{ ai hmktmo{mh zco{lo ocd}l`n2@. Hmktmo{mh {pnxfm{`{
O. locn}xtx`an
D. locod{atzx`anK. ohyonkmh kftan`k c`ymt h`{mo{m
@@. Odnatloc h`{xt`d}x`an at h`c}x`anO. aymtfphtox`anD. `nktmo{mh koz`ccotp zmtlmod`c`xp c`gm `n
{mzx`kml`o
@@@. Odnatloc mvktmx`an at hmetohox`anO. nmzftax`k {pnhtalmD. d}tn{K. fmlattfoemH. kmtxo`n koxodac`k {xoxm{
M. ca{{ ai ztaxm`n ital xfm h`em{x`ym xtokx
@Y. Totm kanemn`xoc hmimkx{O. fpzaocd}l`nml`o
D onocd}l`nml`o