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Serum Test results
200 250
< 200Scores of less than 200 should be considered questionable and only be included if the aller-gens are found in the horse’s environment and they relate to the clinical history.
200-250Scores in this range should be considered significant if the allergens are found in the horse’s environment and they relate to the clinical history.
> 250Scores of 250 or above are unusually high. These allergens are significant especially if they are found in the horse’s environment and relate to the clinical history.
* Elisa Absorbance Units. EA indicate the level of allergens specific IgE detected. The magnitude of the signal does not necessarily correlate with the severity of the disease but does reflect the horse’s immune response to allergens.
Owner name:Animal Name:Species:Veterinarian:Veterinary practice:Practice details: Phone / Fax: Email:Test type:Date tested:Test number:Customer number:
Allergen EA Units*
1
ExampleExampleHorseJ. LeiteArtuvet Animal HealthVijzelweg 11, 8243 PM Lelystad, NL
Complete environmental06/01/20202310006632
Timothy grass
Perennial ryegrass
Bermuda grass
Oat pollen
Rye pollen
Copra mite
Farinae mite
Hay mite
House dust mite
Grain mite
Midges
Horse fly
Mosquito
Birch, Alder, Hazel
Beech
Elm
Poplar
Willow
Ash
Privet
Olive
Cypress
Common mugwort
Stinging nettle
English plantain
Lamb's quarter
Dandelion
Sorrel, sheep/red
Common ragweed
Alternaria alternata
Aspergillus fumigatus
Cladosporium herbarum
841
717
809
355
160
564
492
325
136
220
902
53
161
21
13
33
31
66
9
28
26
6
15
161
387
54
178
244
127
22
9
32
Serum Testtreatment advice
Step 1 - Select a treatment option
Go to the next page for step 2 - Ordering
Treatment option 2
When costs or compliance influence the treatment, pollen mixtures can be an alternative to treatment option 1.
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19.
Treatment option 1
This treatment option contains indivi- dual allergens only. Most dermatologists recommend to include individual allergens in the treatment.
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. Positive, what now?
Once all other causes for the symptoms have been ruled out, atopy or insect bite hypersensitivity is the diagnosis. Since IgE has been found for one or more allergens, you can proceed with immunotherapy. Where there are a high number of positive allergens, this does not affect the efficacy of the immunotherapy.
How to proceed with immunotherapyPlease select a treatment option from Step 1 or select the allergens yourself by composing your own treatment. Allergens should be selected based on the clinical history of the patient. Once you have completed Step 1 move onto Step 2 overleaf.
This option results in: subcutaneous
immunotherapy
*Also available in sublingual immunotherapy (oral spray)
This option results in: subcutaneous
immunotherapy
*Also available in sublingual immunotherapy (oral spray)
2
Questions about the treatment options? Read the following pages or call us at +31 320 783 111.
Compose it yourself
Prefer to compose your own therapy based on the clinical history? Please enter the desired allergens below.
Artuvetrin® subcutaneous immuno- therapy: up to 8 allergens and/or allergen mixtures can be included into 1 vial. For cases with more than 8 allergens, additional vial(s) will be produced.
Timothy grassPerennial ryegrassBermuda grassOat pollenCopra miteFarinae miteHay miteGrain miteMidgesEnglish plantainSorrel, sheep/red
2 vials
Grass pollen mixWeed pollen mix 2Copra miteFarinae miteHay miteGrain miteMidges
1 vial
Serum Testordering treatment
Artuvetrin® subcutaneous immunotherapy It lasts for 9 to 10 months of treatment
Read more on the next page for Step 3 - Starting the treatment 3
Confirm your order
Step 2 - Ordering the treatmentSelect your preferred product
recommended
Veterinary practice:
Delivery address:
Alternative delivery address (if applicable):
Date:
Signature:
Order your treatment quick and easily online
Visit artuvet.com and click ‘online ordering’.At your personal dashboard you can request serum tests, order treatment and download brochures. Reorders can be done easily in your order history.
After selecting the treatment option and product, please email this form to [email protected] order through our website artuvet.com
Do you need support?If you have any questions or if you need support in the diagnosis or treatment of a patient, please contact our medical department by phone +31 320 783 111 or by email [email protected]
Sublingual immunotherapy (oral spray)
Sublingual immunotherapy can be an alternative in for cases with an aversion to needles, do not show improvement to subcutaneous injections or when a daily dosage is prefered.
Sublingual immunotherapy single (1 x 30ml) Treatment lasts for 3 months
Sublingual immunotherapy double (2 x 30ml - same allergens/composition) Treatment lasts for 6 months
For more information contact us at [email protected]
alternative option
Online orderingOnline ordering
Delivery within 8-10 days
Serum Teststarting treatment
Step 3 - Starting the treatmentFrequently asked questions
Read more on the next page for more information about Next+ 4
What is the dosage schedule?
Subcutaneous injections are administered with gradually increasing dosages. The schedule below is applicable for horses. Please keep an eye on the patient for at least 30 minutes after every injection for any side effects.
Is it possible to deviate from the standard dosing schedule?
Yes, however this depends on the situation. Please contact our medical department at +31 320 783 111 for advice and support.
What is the success rate of Artuvetrin®?
The success rate of Artuvetrin® Therapy is 84% for horses. Patients who respond, may expect a recovery from 50% up to 100%. Symptomatic medication might be stopped completely or decreased significantly once the 1ml dose has been achieved.
What if the patient did not respond at all?
If the patient did not show any improvement at all after 12 months, please contact our medical department on +31 320 783 111. There can be several reasons for a 0% response, concomitant food allergy, reaction to new allergens or not effective. We are happy to evaluate each case and help you with the relevant follow up.
If the symptoms are seasonal, can I administer only during that time?
No, it should be administered continuously and life-long. If discontinued for a long period the immunological tolerance may be decreased and the treatment will have to be restarted from the initial dosage.
What is the best time to start the treatment?
The treatment can be started at any time. It is recommended to have the skin under control before starting Artuvetrin®.
Do I need to stop symptomatic medication before starting Artuvetrin®?
Symptomatic medication does not need to be stopped and it can help to keep the skin calm and under control in the initial phase (increasing dosage) of the desensitisation. Symptomatic medication does not affect the efficacy of the treatment and can be continued.
When can I expect to see improvements?
In general, improvement can be noticed after 4 to 6 months. In some cases after 1 month. If there is no improvement at all after 6 months, please contact us at +31 320 783 111. We are happy to help you with your case.
What to do with cases where the symptoms come back?
In case of a flare-up, the symptoms suddenly appear or worsen. This means that the animal has risen above the pruritic threshold. It can happen for different reasons:• increased contact with allergens• secondary infection (yeast, bacterial, etc.)• other skin irritation due to mites, more or less washing, etc.
With a flare-up, it is important to find the cause and prevent it. If the cause is unknown, it can sometimes be sufficient to correct the symptoms with temporary symptomatic medication.
Can I stop the treatment if the symptoms are not present anymore?
No, it is life long and should not be stopped. When stopping there is a significant chance the symptoms will come back for the symptoms to come back and restarting the treatment will not be as affective as before.
Artuvetrin® is a life-long treatment and compliance is keyAllergy is a chronic disease and every 10 months a follow-up vial is required.
Continue with 1.0 ml every 4 weeks for at least 12 months.If noticeable results, Artuvetrin® is a lifelong treatment.
Dosage
0.2 ml
1.0 ml
0.6 ml
1.0 ml
0.4 ml
1.0 ml
0.8 ml
1.0 ml
Adviced schedule
Week 1
3 weeks later (week 10)
2 weeks later (week 5)
4 weeks later (week 17)
2 weeks later (week 3)
3 weeks later (week 13)
2 weeks later (week 7)
4 weeks later (week 21)
5
Serum Testabout Next EQ
About Next EQFrequently asked questions
If there are a lot of positives, will immuno- therapy be useful?
Where there are a high number of positive allergens, this does not affect the efficacy of the immunotherapy.
Do the units correlate with the clinical signs?
No, the magnitude of the units does not necessarily correlate with the severity of the disease but does reflect the animal’s immune response to allergens.
Can symptomatic medication affect the result?
Corticosteroids may affect the serum test results if administered longer than 2-3 months (oral medication).
What can the owner do to prevent exposure to the positive allergens?
Pollen• Restrict outdoor activity and only put the horse to pasture in the morning, evening or after rainfall when pollen numbers are low.• Move the horse to a different environment or a different barn.• Keep windows and doors of the barn closed on warm and windy days and open them when pollen numbers are low.• Dry blankets, saddle pads and leg bandages inside.
House dust and storage mites• Minimalise dust in the barn and consider purchasing rubber mats to replace stall bedding.• Wash blankets, saddle pads and leg bandages regularly with 60⁰C hot water.• Consider keeping the horse outside or restrict stabling.• Use airtight containers to keep food tightly closed and store in a cool, dark and dry environment.• Reduce food stockpiles by buying smaller amounts. Maximum storage time should be less than 30 days.• Wipe the face with a damp cloth after finishing a meal to remove food remains and keep food buckets, bins and tubs clean.• Keep the humidity and temperature in the barn lower than 45% and 21⁰C, consider using a dehumidifier.
Insects• Reduce exposure to insects by moving horses away from standing water, manure piles, compost and cattle.• Stable the horse before dusk and until after dawn.• Use fly sheets or masks sprayed with permethrin repellant, using a ± 32 x 32 per 2.5-cm grid meshing.• Place box fans within the stall.
Moulds• Remove moulds from damp environments and surfaces with a fungi cleaner.• Lower the humidity and increase ventilation indoors.• Consider keeping the horse outside or restrict stabling.• Avoid forest walks in autumn or in humid weather.
Do you have any additional questions?Please call our medical department on +31 320 783 111 or send an email to [email protected].
