UMR 866
PhD Position available
UMR 866, Lipide Nutrition Cancer, Faculté de Médecineet de
Pharmacie, 7 Bd Jeanne d’Arc, F21079, Dijon, France
Team : Heat Shock Protein. Cell Death cellular differentiation
& tumorigenic properties
Early October, 1st, 2013 - 3 Years
A 3 Years funded PhD position is available at the Heat Shock
Protein group of the UMR866, Lipide Nutrition Cancer, research
center under the supervision of Dr. Garrido Carmen and Dr.Micheau
Olivier.
TRAIL-induced apoptosis signaling regulation by HSPs :
Heat shock proteins and death-domain containing receptors of the
TNF familly play a key role in controlling apoptosis and tumor
progression. Inhibition of some HSPs increase apoptosis induced by
TNF ligands including TRAIL and show promissing antitumour
activity. However, although HSPs are known to regulate the function
and stability of a large number of proteinsby affecting their
sumoylation and /or ubiquitination, including proteins involved in
the regulation of apoptosis at the mitochondrial level, the
molecular mechanisms underlying cell sensitization to TRAIL-induced
cell death remain largely unkown. This PhD project will be
dedicated to dissect the molecular mechanisms involved in the
restoration of this apoptotic machinery and to develop efficient
antitumor therapies based on HSP inhibitors and/or TRAIL or TRAIL
derivatives.
Requested Profile : The applicant should have a Master 2 diploma
and a previous training period in a research lab. We are seeking a
highly motivated and curious individual with prior background in
Cancer research and molecular biology. French speaking is not a
requirement.
Candidates should send their application (CV, motivation letter
and 2 recommendation letters) to [email protected]
Closing Date August, 23rd 2013. Interview Date September
2013.
http://inserm-u866.u-bourgogne.fr/en/equipes_en.php
Micheau et al. Brit J Pharmacol 2013Jacquemin et al. Haematol
2012Dorard et al. Nat Med 2011Rérole et al. Cancer Res 2011Pavet et
al. Cancer Res 2010
