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31 January 2014Abstracts Close
28 February 2014Early Bird Registration Cut-Off
31 May 2014Late Breaker abstracts close
Important Dates
Invitation to the 17th World Congress of Basic and Clinical Pharmacology
It is our privilege to invite you to participate in the 17th World
Congress of Basic and Clinical Pharmacology (WCP2014)
from 13-18 July 2014 in Cape Town, South Africa. This historic
event marks the first ever IUPHAR World Congress to be hosted
on the African continent and coincides with the celebration of 20
years of democracy in South Africa. We believe that WCP2014
will leave a lasting impression on all of us. Africa is a continent
of many wonders and firsts. It is recognised as the “cradle
of humankind”, and is blessed with a diversity of people and
cultures, majestic and breathtaking landscapes, as well as an
unsurpassed beauty and diversity of animal and plant life. The
host city of Cape Town is set on a peninsula of rocky heights with
dramatic ocean views. Moreover, it is situated at the foothills of
Table Mountain, recently acclaimed as one of the seven natural
wonders of the world.
Visitors to the city will appreciate the range of world-class
accommodations within walking distance of the modern venue,
the Cape Town International Convention Centre. Only 20 minutes
away is the Cape Town International Airport, offering flights by
international air carriers directly from Europe, the Americas, and
Asia. The congress theme is “Pharmacology at the cutting-edge”.
We will discuss the major breakthroughs and developments in the
field of pharmacology – from fundamental to clinical pharmacology
and translational research addressing healthcare challenges
and patient outcomes. In addition to an outstanding scientific
programme with Nobel Laureates and other world leaders, there
will be numerous opportunities for attending satellite meetings,
workshops, hands-on learning and networking. These will be
complemented by exciting social events, such as the Nelson
Mandela International Day excursion. WCP2014 will have a strong
focus on opportunities for young scientists. Pharmacology for
Africa, an integral partner to the World Congress, will provide a
specific platform for you to engage with colleagues from Africa. We
are grateful for the support of the communities of pharmacologists
around the globe in so many ways. For example, the British
Pharmacological Society young pharmacologists have been
selling T-shirts and the Hong Kong Pharmacology Society provided
sponsorship to support the participation of young pharmacologists
from Africa.
We invite you to extend your stay to explore South Africa and other
countries in Africa, perhaps on safari or a multitude of other touring
options. Come and experience the Cape floral kingdom, the “Big
Five” and so much more. Accompanying persons will revel in the
chance to experience Cape Town and its beautiful peninsula where
the unexpected is always just around the corner. We look forward
to welcoming you to Cape Town, with its natural beauty, creative
freedom and incredible spirit.
Come embrace a truly South African and African
experience!
Douglas Oliver and Tiaan Brink
WCP2014 President and Secretary-General
Pharmacology InternationalNo. 81 December 2013 The semi-annual newsletter from the International Union of Basic and Clinical Pharmacology
In This Issue
WCP2014 Abstract Submission Instructions Pg. 2 Scientific Programme Pg. 3 Speakers Pg. 10 Young Investigator Awards Pg. 26 Accompanying Person Programme Pg. 27 Celebrate Nelson Mandela Day Pg. 29 REGISTRATION Pg. 30 Bursary Guidelines Pg. 31 Satellite Meetings Pg. 32 African Tours Pg. 34 WCP2014 Sponsors Pg. 37 Clinical Pharmacology Pg. 38 Nomenclature, Database & Guide to Pharmacology Pg. 41
In Memory William C. Bowman Pg. 44
IUPHAR Updates Folke Sjöqvist Symposium Pg. 48 Gastrointestinal Activities Pg. 54 Pediatric Clinical Pharmacology and GRIP Pg. 58 Pharmacogenetics and Pharmacogenomics Pg. 61
Member Updates Asia Pacific Federation of Pharmacologists Meeting hosted by the Chinese Pharmacological Society Pg. 63
Member Anniversaries The Italian Society of Pharmacology 75th Pg. 68 2014 Anniversaries Pg. 71
Meeting Invitations International Year of Crystallography Pg.76 International Society of Pharmacovigilance Pg. 73 International Society for Serotonin Research Pg. 74 Drug Metabolism and Transport Methods Pg. 76 Renin-Angiotensin-Aldosterone System Pg. 78 Pharmacology Education Pg. 79 WCP2014 Pg. 80 James Black Conference Pg. 81 Upcoming Events Pg. 82
www.WCP2014.org
PharmacologyInternational
2
Better Medicines through Global Education and
Research The Scientific Programme Committee
invites you to submit abstracts for poster
presentation at WCP2014. We will
accept abstracts on a range of topics related to
pharmacology research, education and practice
(see below list of topic categories).
• Deadline for submission: 31 January 2014,
received electronically not later than 16:00
South African Time (GMT +02:00).
• Notification of acceptance decision: End of
February 2014 via email. The Programme
Committee may select a small minority of
abstracts for oral presentation, which will be
negotiated with presenters.
• Format: Abstracts should be submitted in
English consisting of four paragraphs with the
following headings: background, methods,
results, conclusions. These paragraphs
should briefly describe the objectives of the
study or investigation, the basic procedures
(study subjects and analytical methods), the
main findings (giving specific data and the
statistical significance, if possible), and the
principal conclusion. The abstract body text
has a limit of 350 words.
ONLINE SUBMISSIONAll abstracts should be submitted electronically via the
online abstract form available on the official website.
You can partially complete, save and return later to
edit and finalise. Once your abstract is ready, you can
submit, after which no changes can be made.
SELECTING YOUR ABSTRACT CATEGORY ON THE ONLINE ABSTRACT SUBMISSION FORMTo organise the extensive list of abstract categories,
they are grouped into several MAIN CATEGORIES,
each subdivided into several SUBCATEGORIES. You
are requested to select an appropriate subcategory
to best describe your abstract topic. Therefore,
select a main category, followed by a subcategory.
You may select a second subcategory, which may
fall under the same or a different main category.
Please find below a list of the main categories:
List of Categories:• Drug discovery & development
• Fundamental pharmacological mechanisms
• Drugs and the brain
• Cardiovascular pharmacology
• Drugs for infectious diseases
• Immunopharmacology
• Drug metabolism and disposition
• Endocrine pharmacology
• Oncology
• Specialised systems pharmacology
• Age-related pharmacology
• Pharmacology and technology
• Clinical pharmacology
• Toxicology
• Pharmacology education
• Regulatory affairs & management
• Veterinary pharmacology
• Other
Here are examples of the selection of two
subcategories:
Example 1
(one main category)
First choice
[Drugs and the brain]
(main category)
[Behaviour]
(subcategory)
Example 2
(two different main
categories)
First choice
[Drugs and the brain]
(main category)
[Behaviour]
(subcategory)
Second choice
[Drugs and the brain]
(main category]
[Depression]
(subcategory)
Second choice
[Oncology]
(main category]
[Cytotoxic agents]
(subcategory)
For assistance with your submission, please contact:Janice Candlish
Project Manager – Medical Division
Scatterlings Conference & Events
Tel: +27 11 463 5085 / Email: [email protected]
Abstract Submission
www.WCP2014.org/index.php/participate/abstracts/online-submissions
December 2013
3
This significant conference will not only deliberate on advances in the field and solutions to current challenges, but also increase awareness of the importance of pharmacology research both in South Africa and our continent.Albert van Jaarsveld, Chief Executive Officer, National Research Foundation, South Africa
It is gratifying that the country’s achievements in the treatment and prevention of diseases such as poliomyelitis, epidemic meningitis, tuberculosis, malaria, human papillomavirus infection, HIV infection and numerous other infections and diseases have been recognized and appreciated. The fact that the 2014 IUPHAR meeting is being held in the country is indication of such recognition and will assuredly give impetus for more.Peter Folb, Past President, South African Society of Basic & Clinical Pharmacology
As founder member and past president of the South African Society for Basic and Clinical Pharmacology, it gives me great pleasure to anticipate and, hopefully, to experience in person, the impact that this historic congress is bound to have on tuition, training, and research in the fields of basic and clinical pharmacology in Africa, and, indeed, the whole world, to prevent and treat disease.Frank Otto Muller, Past President, South African Society of Basic & Clinical Pharmacology
This meeting offers a tremendous opportunity for scientists across the globe to network and share the latest developments. WCP2014 also provides a venue for young scientists to interact with scientific leaders in basic and clinical pharmacology.Judith A. Siuciak, Executive Officer, ASPET
Continued on page 4...
Introduction to the scientific programmeThe programme committee members have all worked hard to develop an exciting scientific programme, which has a good balance between
basic and clinical pharmacology. We have a very strong field of twenty plenary speakers, each of whom is at the cutting edge of their discipline.
There are two parallel plenary sessions each morning, with a basic and a clinical pharmacology topic in nearly all sessions. There is a very diverse
geographic representation of speakers. The range of session topics is very wide, including pharmacology education and drug regulation. We have
tried hard to avoid session topics with similar themes being scheduled at the same time in the seven parallel sessions. Many of the session topics
are complemented and expanded on in specialised satellite meetings during, before and after the congress.
We hope delegates enjoy a stimulating congress.
17:30 - 18:00WCP2014 Opening Ceremony
18:00 - 18:30
18:30 - 19:00 Opening Keynote Speaker sponsored by NWUR Lefkowitz. G Protein Coupled Receptors 19:00 - 19:30
19:30 - 20:00
WCP2014 Welcoming Function20:00 - 20:30
20:30 - 21:00
21:00 - 21:30
21:30 - 22:00
Prof Gary Maartens
Chair, Scientific Programme Committee
Sunday 13 July 2014
PharmacologyInternational
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Continued on page 5...
Monday 14 July 2014
Track 1 2 3 4 5 6 7
7:30 - 8:00 Meet the Expert 1
Meet the Expert 2
Meet the Expert 38:00 - 8:30
8:30 - 9:00 Plenary Lectures 1 & 2 co-sponsored by BPSPK Rangachari. Basic Pharmacology Education Simon Maxwell. Challenges in training tomorrow's prescribers
Plenary Lectures 3 & 4Yoshikatsu Kanai. Amino acid transporters in oncologyRonald Taylor. Monoclonal antibodies in cancer
9:00 - 9:30
9:30 -10:00
10:00 - 10:30 Tea break
10:30 - 11:00Pharmacology
of novel tuberculosis
regimens
New drug research and development for Alzheim-er’s disease
Natural Products:
Neuro-Meta-bolic-Vascular Mechanisms
Therapeutic monoclonal antibodies in
oncology
What every pharmacologist should know about children
Epigenetic reg-ulation of drug metabolizing enzymes and transporters
LB111:00 - 11:30
11:30 - 12:00
12:00 - 12:30
Lunch & poster viewing12:30 -13:00
13:00 -13:30
13:30 - 14:00
Antibiotic resistance
New targets for stress
Therapeutic targets for treating or preventing
insulin resist-ance and car-diometabolic complications
Targeted small mole-cule therapy in oncology
(*BPS) Communicating with the public and the policy
community
Orphan G protein-coupled
receptors- What are the new ligand
and new drug targets?
LB2
14:00 - 14:30
14:30 - 15:00
15:00 - 15:30 Tea break
15:30 - 16:00
Novel therapeutic strategies in
HIV
Calcium sign-aling in brain
diseases
Advances in reproductive
pharmacology
Targeting B cell signaling in oncology
2020 Vision for Pharmacology
Education
Mathematical Modelling and
Computer Simulation –
Applications to Healthcare
LB3
16:00 - 16:30
16:30 - 17:00
17:00 - 17:30
PharfA Symposium 2: Traditional
Medicine Development
Strategies
Satellite - New Web-based Approaches for Teaching
Clinical Pharmacolo-gy: Workshop
Pscribe
Satellite: IATDMCT
symposium - Frontiers in Therapeutic Drug Man-agement
IUPHAR Clinical Division Council Meeting
17:30 - 18:00
18:00 - 18:30
18:30 - 19:00
19:00 - 19:30
SASBCP Gen-eral Assembly Society Meet-
ings & Social Functions
Society Meet-ings & Social Functions
Society Meetings & Social Functions
Society Meet-ings & Social Functions
Society Meet-ings & Social Functions
Society Meetings & Social Functions
19:30 - 20:00
20:00 - 20:30
20:30 - 21:00
21:00 - 21:30
21:30 - 22:00
This significant conference will not only deliberate on advances in the field and solutions to current challenges, but also increase awareness of the importance of pharmacology research both in South Africa and our continent.Albert van Jaarsveld, Chief Executive Officer, National Research Foundation, South Africa
It is gratifying that the country’s achievements in the treatment and prevention of diseases such as poliomyelitis, epidemic meningitis, tuberculosis, malaria, human papillomavirus infection, HIV infection and numerous other infections and diseases have been recognized and appreciated. The fact that the 2014 IUPHAR meeting is being held in the country is indication of such recognition and will assuredly give impetus for more.Peter Folb, Past President, South African Society of Basic & Clinical Pharmacology
As founder member and past president of the South African Society for Basic and Clinical Pharmacology, it gives me great pleasure to anticipate and, hopefully, to experience in person, the impact that this historic congress is bound to have on tuition, training, and research in the fields of basic and clinical pharmacology in Africa, and, indeed, the whole world, to prevent and treat disease.Frank Otto Muller, Past President, South African Society of Basic & Clinical Pharmacology
This meeting offers a tremendous opportunity for scientists across the globe to network and share the latest developments. WCP2014 also provides a venue for young scientists to interact with scientific leaders in basic and clinical pharmacology.Judith A. Siuciak, Executive Officer, ASPET
December 2013
5
Tuesday 15 July 2014
Track 1 2 3 4 5 6 7
7:30 - 8:00Meet the Expert 4 Meet the Expert 5 Meet the Expert 6
8:00 - 8:30
8:30 - 9:00 Plenary Lectures 5 & 6 Kozo Kaibuchi. Protein Phosphorylation in Signal transductionRichard Neubig. Signal transduction in therapeutics
Plenary Lectures 7 & 8 Brian Strom. Use of pharmacoepidemiology to study the
Doriano Fabbro. Tyrosine kinase inhibitors
9:00 - 9:30
9:30 -10:00
10:00 - 10:30 Tea break
10:30 - 11:00New drugs for
neglected infectious diseases
Protein S-nitrosylation
as a therapeutic target
Obesity: Basic and clinical pharma-
cology
TGFß in radiation biology & therapy
IUPHAR Natural Products Section
Symposium
Innovations in drug therapies – The future is now
LB411:00 - 11:30
11:30 - 12:00
12:00 - 12:30
Lunch & poster viewing12:30 -13:00
13:00 -13:30
13:30 - 14:00
Pharmacogenet-ics in infectious
diseases
Optimizing anti-epilepsy drug
discovery
Renin-angiotensin system
pharmacology revisited
DNA repair and topoisomerase inhibitors in oncology
Internet-based solutions to
alleviate shortages of pharmacology
faculty in develop-ing countries
Plants and animal toxins as sources of new therapeutic
drugs
Structural basis for ion channel phar-
macology
14:00 - 14:30
14:30 - 15:00
15:00 - 15:30 Break
15:30 - 16:00Recent break-
throughs in malaria treatment
The addictive brain through different receptor subtypes
Aspirin, the wonder drug
Sarcoma genetics and targeted thera-peutics
Regulatory challenges in herbal and traditional medicines
NC-IUPHAR and guide to pharma-gology
LB616:00 - 16:30
16:30 - 17:00
17:00 - 17:30IUPHAR's Analytical Pharmacology Lecture. Dr Arthur Christoloupos. Adventures in allostery: From function to structure
17:30 - 18:00
18:15 - 19:45 IUPHAR General Assembly
Meeting registrants are welcome to watch the General Assembly proceedings,
IUPHAR is honored and proud to sponsor the 17th World Congress of Basic and Clinical Pharmacology held the 13th to 18th July 2014 in Cape Town, South Africa. The Congress has a remarkable scientific program where the latest findings in basic and clinical pharmacology will be discussed in 20 plenary lectures, more than 80 symposia, 15 meet the expert sessions, poster sessions, the IUPHAR Young Scientists Competition, and more than 30 satellite meetings. In addition, spectacular pre and post Congress tours have been organized. I do hope to meet you in Cape Town! Patrick du Souich, President, IUPHAR
however, please avoid sitting in the seats reserved for the voing delegates.
effects of pharmaceuticals
Continued on page 6...
PharmacologyInternational
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Better Medicines through Global Education and
Research
Wednesday 16 July 2014
Track 1 2 3 4 5 6 7
7:30 - 8:00 Meet the Expert 7
Meet the Expert 8
Meet the Expert 98:00 - 8:30
8:30 - 9:00 Plenary Lectures 9 & 10 Bruce McEwen. Neurobiological effects of stress Stephen Stahl. Psychopharmacology Mech-anism of action of the atypical antipsychot-ics in psychosis and mood disorders: The pines, the dones, two pips and a rip
Plenary Lectures 11 & 12 Suzanne Hill. Medicines selection in high income countries Clive Ondari. Medicine selection in emerging economies
9:00 - 9:30
9:30 -10:00
10:00 - 10:30 Tea break
10:30 - 11:00
Advances in antiviral
therapy
Rethinking mood thera-peutics: Novel
pharmaco-logical ap-
proaches for anxiety and depression
Manipula-tion of gut microbi-ome as a treatment
strategy for gastroin-testinal & metabolic disorders
(*IUPHAR-Clin Div) Update in geriatric
pharmacol-ogy
Managed introduction of new medicine
Evolution, sport and modern diseases
IUPHAR Young Scientist Com-
petition 1
11:00 - 11:30
11:30 - 12:00
12:00 - 12:30
Lunch & poster viewing12:30 -13:00
13:00 -13:30
13:30 - 14:00
Vaccine de-velopment
Phosphodi-esterase 4
inhibitors as novel anti-in-flammatory
drugs
Neuroen-docrine
regulation of GI protec-
tion: Central & peripheral pathways
Contro-versies in essential
medicines
Clinical phar-macometrics: Application
to target concentration intervention
Evaluating drug-drug interac-
tions with therapeutic
proteins
IUPHAR Young Scientist Com-
petition 2
14:00 - 14:30
14:30 - 15:00
15:00 - 15:30 Break
15:30 - 16:00 Inflamma-tion and
allergy: New therapeutic avenues
New ap-proaches for non-neu-ronal brain diseases
Lipid modifying strategies beyond statins
Problems with OTC analgesics
Global PGx-based personalized medicine
Emerging drug targets
IUPHAR Young Scientist Com-petition 3
16:00 - 16:30
16:30 - 17:00
17:00 - 17:30
17:30 - 18:00
18:00 - 18:30
18:30 - 19:00
19:00 - 19:30Break
19:30 - 20:00
20:00 - 20:30
WCP2014 Gala dinner (ticketed - paid)20:30 - 21:00
21:00 - 21:30
21:30 - 22:00
IUPHAR is proud to sponsor its first World Congress on the African continent. It addition to a marvelous venue, WCP2014 attendees will enjoy and profit from an outstanding scientific program covering the latest advances in basic and clinical pharmacology.S.J. Enna, Secretary-General, IUPHAR
Continued on page 7...
December 2013
7
Thursday 17 July 2014
Track 1 2 3 4 5 6 7
7:30 - 8:00Meet the Expert 4 Meet the Expert 5 Meet the Expert 6
8:00 - 8:30
8:30 - 9:00 Plenary Lectures 13 & 14 co-sponsored by BPSMartin Michel. To pee or not to pee: New concepts in urinary tract pharmacology (Autonomic pharmacology of the urogenital tract)Salvator Moncada. Cardiovascular pharmacology
Plenary Lectures 15 & 16 co-sponsored by BPSSimon Mallal. Mechanisms of drug hypersensitivityMunir Pirmohamed. Drug safety science
9:00 - 9:30
9:30 -10:00
10:00 - 10:30 Tea break
10:30 - 11:00Glucocorticoids: New insights into mechanisms of
action
Targeting the TRPA1 channel for
pain treatment
Hydrogen sulfide in GI health and
disease
Hot topics in phar-macoeconomics
Using clinical tox-icology studies to
improve biomarkers and regulatory
decisions
The role of drug transporters in inter-individual
variations in drug response
LB711:00 - 11:30
11:30 - 12:00
12:00 - 12:30
Lunch & poster viewing12:30 -13:00
13:00 -13:30
13:30 - 14:00Immunopharmacology
of the systemic inflammatory re-sponse syndrome
The nitric oxide-cGMP path-way in neuropsy-chiatric illness: An
update
Advances in GI pharmacology:
New approaches to upper and lower
GI ulcers and inflam-mation
Can academic drug discovery deliver in
rare diseases?
IUTOX session on nanomedicines
Understanding and predicting the ex-tent of drug-drug
Interactions
ORPHEUS PhD Standards: Bridging PhD programs to promote global collaboration
14:00 - 14:30
14:30 - 15:00
15:00 - 15:30 Break
15:30 - 16:00Immunobiologicals and chronic inflam-
matory diseases
Nitric oxide research reveals new ideas in pharmacology
Endothelium-de-pendent control of vascular tone
Pharmaco-epidemi-ology: At the cutting edge
The changing face of pediatric drug development
Understanding drug induced liver Injury
PharfA Symposium 3: Biological medi-cines development
16:00 - 16:30
16:30 - 17:00
17:00 - 17:30
IUPHAR Clinical Division General Assembly
Satellite - New Web-based Approaches for Teaching Clinical Pharmacology: Workshop Pscribe
17:30 - 18:00 PharfA Evening: Welcome & Introduction
18:00 - 18:30PharfA Lecture (Chair: Prof M. Khayyal; Speaker: Prof Alex Dodoo)
18:30 - 19:00
PharfA General Assembly19:00 - 19:30
Society Meetings & Social Functions
Society Meetings & Social Functions
Society Meetings & Social Functions
Society Meetings & Social Functions
19:30 - 20:00
20:00 - 20:30
PharfA Reception (ticketed -free of charge)20:30 - 21:00
21:00 - 21:30
21:30 - 22:00
Chinese pharmacologists are keen on taking the opportunity to attend WCP2014 to conduct academic communications, develop cooperation and promote friendship with international counterparts. We also look forward to the opportunities to demonstrate our research progress.Guan-Hua Du, President (left), & Yong-Xiang Zhang, Vice-President & Secretary-General (right), Chinese Pharmacological Society
Continued on page 8...
PharmacologyInternational
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Better Medicines through Global Education and
Research
Friday 18 July 2014
Track 1 2 3 4 5 6 7
7:30 - 8:00Satellite 12 Satellite 13 Satellite 14 Satellite 15
Meet the Expert 4
Meet the Expert 5
Meet the Expert 68:00 - 8:30
8:30 - 9:00 Plenary Lectures 17 & 18 Nicholas Holford. Rational clinical parmacology:
Kazuhide Inoue. Purinergic signaling in neuropathic painConcentration not dose (Pharmaco-metrics)
Plenary Lectures 19 & 20 co-sponsored by BPSDan Roden. Moving pharmacogenomic
Nicholas White. Antimalarial pharmacology
9:00 - 9:30
9:30 -10:00
10:00 - 10:30 Tea break
10:30 - 11:00 Global HIV clinical
pharmacology capacity building and implementa-tion research
Combination medications
as novel treatments
for stimulant addiction
New chal-lenges for
the treatment of diabetes mellitus
Epigenetic mechanisms in cell- and drug-based heart failure
therapies
GRIP – Global training
programs in paediatric
pharmacol-ogy
Innovative methods
for assess-ing drug
toxicity and efficacy
LB8
11:00 - 11:30
11:30 - 12:00
12:00 - 12:30WCP2014 Closing Ceremony
12:30 -13:00
13:00 -13:30Lunch Break
13:30 - 14:00
14:00 - 14:30
Nelson Mandela Day - Social Responsibility Excursion for All Delegates
14:30 - 15:00
15:00 - 15:30
15:30 - 16:00
16:00 - 16:30
16:30 - 17:00
The South African Society of Basic and Clinical Pharmacology has succeeded in setting an important milestone for the African continent, where pharmacologists from the ends of the earth: North, South, East and West indeed shall meet and will stand face to face, crossing every border, no matter what creed or breed, under the flag of IUPHAR.Mohamed T. Khayyal, President, Egyptian Society of Pharmacology & Experimental Therapeutics.
The most pleasing aspect of this wonderful meeting to me is that it will take place for the first time in the so far pharmacologically neglected continent of Africa!Paul M. Vanhoutte, Past-President IUPHAR, and President, the Hong Kong Pharmacology Society
discovery to implementation
December 2013
9
ACTIVITIES IN AND AROUND CAPE TOWN
Table Mountain Aerial Cableway
tablemountain.net
Sunset cruise – departing from the V&A Waterfront
http://www.waterfrontboats.co.za/
Whale Watching in Hermanus
http://www.hermanus.co.za/whales.asp
Kirstenbosch National Botanical Gardens
http://www.sanbi.org/gardens/kirstenbosch
To book Day Tours contact:http://www.qualitytouringservices.co.za/index.htm
Telephone: +27 21 979 5936
Facsimile: +27 21 979 5934
Mobile: (24hrs): 082 657 3443
E-Mail: [email protected]
Activities in and around Cape Town
ACTIVITIES IN AND AROUND CAPE TOWN
Table Mountain Aerial Cableway
tablemountain.net
Sunset cruise – departing from the V&A Waterfront
http://www.waterfrontboats.co.za/
Robben Island Museum
www.robben-island.org.za/
Noon Gun
http://bokaap.co.za/noon-gun/
Robben Island Museum
www.robben-island.org.za/
Noon Gun
http://bokaap.co.za/noon-gun/
Whale Watching in Hermanus
http://www.hermanus.co.za/whales.asp
Kirstenbosch National Botanical Gardens
http://www.sanbi.org/gardens/kirstenbosch
Sunset at Clifton Beach
Shark Cage Diving
http://www.sharkdiveafrica.co.za
PharmacologyInternational
10
Better Medicines through Global Education and
Research
SpeakersRobert Lefkowitz Opening Keynote Speaker G Protein-Coupled Receptors
Robert Lefkowitz, Professor at Duke University
Medical Center, Nobel Laureate of Chemistry
in 2012, has been involved for more than three
decades in G protein-coupled receptors. He has
made numerous discoveries in this field directed
at the molecular properties and regulatory
mechanisms that control the function of plasma
membrane receptors for hormones and drugs
under normal and pathological circumstances. His
contributions greatly assisted our understanding
and development of new therapeutic strategies
for several disease areas. Dr. Lefkowitz has,
amongst other findings, isolated eight of the nine
subtypes of adrenergic receptors and determined
their complete amino acid sequences. The
ß-adrenergic receptors are among the most
common G protein–coupled receptors. Dr.
Lefkowitz is further widely recognised for his
dedication to training and mentoring of his
students. Over the years, he has trained more
than 200 graduate students and postdocs in his
laboratory. Young pharmacologists participating
in Cape Town will have the privilege to meet and
engage with him. Please visit Dr. Lefkowitz’s
website for details of his activities: http://www.
lefkolab.org/
Arthur Christopoulos IUPHAR lectureAdventures in allostery: From function to structure
Arthur Christopoulos PhD is Professor of
Pharmacology at Monash University and Principal
Research Fellow of the National Health and
Medical Research Council of Australia. He is one
of the world’s leading receptor pharmacologists
and his key contributions to the field have had
a major impact on modern GPCR focused drug
discovery. In recognition of his outstanding
research, Prof Christopoulos is the recipient
of the 2013 John J. Abel Award, sponsored by
Pfizer, for his fundamental contributions to the
field of analytical pharmacology and the study of
G protein-coupled receptors, notably in his work
on allosteric modulation and biased signaling of
GPCRs. He is the highest-ranked Australian based
scientist in the disciplines of pharmacology and
toxicology. Additionally, Dr. Christopoulos also
serves on the editorial board of eight international
journals, including Molecular Pharmacology,
the Journal of Pharmacology and Experimental
Therapeutics, and Pharmacological Reviews.
Alex Dodoo PharfA Lecture
Alex Dodoo BPharm,
MSc, PhD, MRPharmS, FPCPharm is Associate
Professor (on sabbatical since January 2013) at
the Centre for Tropical Clinical Pharmacology,
University of Ghana Medical School (UGMS).
He serves on several local and international
advisory, training and safety committees,
including Director, WHO Collaborating Centre
for Advocacy and Training in Pharmacovigilance
at UGMS and Chairman of the Global Vaccine
Safety Initiative.
He is a longstanding member of numerous
professional pharmaceutical associations and
is the recipient of the Senior Pharmacovigilance
Fellowship Award from the WHO Collaborating
Centre for International Drug Monitoring, Uppsala,
Sweden. Prof Dodoo is the author/co-author
of various manuscripts and full papers in peer-
reviewed journals, has written a book (Healthy
Secrets – a layperson’s guide to health issues) and
contributed to several other books and manuals.
Continued on page 11...
December 2013
11
Doriano Fabbro Tyrosine kinase inhibitors
Doriano Fabbro PhD is Chief Scientific Officer
of PIQUR, a Swiss pharmaceutical company
focusing on the discovery and development of innovative anti-cancer
drugs. After receiving his PhD in cell biology and biochemistry at
the University of Basel, he spent twelve years as Group Leader in
Molecular Tumor Biology.
He then joined the Oncology Group of Ciba-Geigy Basel. After the
merger of Ciba-Geigy with Sandoz in 1996 he served at Novartis
as Head of Kinase Biology until 2012. Dr Fabbro has contributed
to the discovery & development of various protein kinase inhibitors
for the treatment of cancer; e.g. Midostaurin®, Glivec®, Afinitor®,
and Tasigna®. Dr Fabbro has more than 200 publications and
numerous patents in the area of protein kinases regulation, structure,
screening and drug discovery. He has been honoured with the
Novartis Oncology President’s Award (2005).
Suzanne Hill Medicine selection in high-income countries
Suzanne Hill BMed (Hons), Grad Dip Epi, PhD, FAFPHM is a
clinical pharmacologist and public health physician, trained at the
University of Newcastle, Australia. She was appointed as Chair of the
Australian Pharmaceutical Benefits Committee in September 2011
and currently also has appointments as Visiting Professor at the
University of Melbourne Medical School and the Australian National
University School of Medicine. Her research interests are related
to the public health and policy aspects of clinical pharmacology,
including access to medicines and use of pharmacoeconomics
and clinical evidence in decision-making.
Previously, Dr Hill worked at the World Health Organization in
Geneva from 2005, as Secretary to the WHO Expert Committee
on Essential Medicines, responsible for the WHO Model List of
Essential Medicines and its implementation in countries. She was
principle investigator for the WHO project on Better Medicines for
Children and played an important role in setting up standards for
guideline development by WHO.
Nicholas Holford Rational clinical pharmacology: Concentration not dose
Nicholas Holford MB, ChB, MSc, MRCP(UK),
FRACP is Professor of Clinical Pharmacology
at the Department of Pharmacology and Clinical Pharmacology,
University of Auckland. He has a keen interest in PKPD modeling,
with particular emphasis in describing disease progression,
influence of drug treatments on disease and dosing of children.
His career spans some forty years and he has been awarded
numerous scholastic and professional honours and awards, the
most recent being the Gary Neil Award for Innovation in Drug
Development, by the American Society of Clinical Pharmacology.
He is the author of a significant number of publications in the
clinical pharmacology field.
Kazuhide Inoue Purinergic signalling in neuropanthic pain
Kazuhide Inoue PhD is Dean of the Department
of Molecular and System Pharmacology at the Graduate School of
Pharmaceutical Sciences, Kyushu University in Japan. Prof Inoue is
actively involved in the progression of pharmacology in Japan and
is involved on an executive level with the Japanese Pharmacological
Society, the Japanese Society for Neurochemistry (currently
President) and the Japanese Pain Society. He has received numerous
awards for his research activities, and was recently honoured with
the Pharmaceutical Society of Japan Award. His current research
project involves examining the mechanisms of neuropathic pain.
Kozo Kaibuchi Protein phosphorylation in signal transduction
Kozo Kaibuchi PhD is Professor of the
Department of Cell Pharmacology at Nagoya
University, Graduate School of Medicine. He began his career as
a Research Associate in the Department of Biochemistry at the
same institution from 1984 to 1989, serving concurrently as a
postdoctoral fellow at the DNAX Research Institute of Molecular
(Pharmaco-metrics)
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Continued on page 13...
and Cellular Biology. He was then named
Assistant Professor at Kobe University School of
Medicine, and was made Associate Professor in
1990.
He was later appointed Professor in the Division
of Signal Transduction at the Nara Advanced
Institute of Science and Technology, where he
remained until 2000. He is a Visiting Professor of
Kobe University and Nara Institute of Science and
Technology, and a Fellow of Institute for Advanced
Research at Nagoya University. He has authored
numerous papers and is the recipient of a number
of prizes, including most recently the Chunichi
Cultural Award (2011).
Yoshikatsu Kanai Fundamental oncology: Amino acid transporters in oncology Yoshikatsu Kanai MD, PhD is Professor of Bio-
system Pharmacology at the Graduate School
of Medicine, Osaka University, a position he
has held since 2007. Prior to this he was on the
Pharmacology and Toxicology faculty at Kyorin
University School of Medicine for fourteen years,
first as Associate Professor and then Professor
and Chair of the department.
Prof Kanai’s particular research interest lies
in the molecular pharmacology of amino acid
transporters and organic anion transporters
and their applications to pharmacokinetics,
pathophysiology, diagnosis and therapeutics.
He has published a plethora of scientific articles
and is a member of numerous global and local
molecular, biochemistry and
ties.
Simon Mallal Mechanisms of drug hypersensitivity
Simon Mallal MBBS is Professor of Medicine
and Director of the Center for Translational
Immunology and Infectious Diseases at Vanderbilt
University, USA. He is also Director of the Institute
of Immunology and Infectious Diseases at
Murdoch University and Clinical Immunologist
and Immunopathologist at Royal Perth Hospital
in Western Australia. He has undertaken
clinical practice management altering research
throughout his career which has informed and
directed his basic science research.
His projects have made significant impact on
clinical and healthcare practice and policy, the
development of new multidisciplinary capacity
and approaches to translational medicine. The
culmination was the establishment of a purpose-
built translational medicine institute which he
leads. He has authored over 200 articles and
book chapters and given over 215 presentations
at scientific meetings. He serves on several
international scientific committees and advisory
boards and received the Western Australian
Premier Science Award in 2006.
Martin Michel To pee or not to pee: New concepts in urinary tract pharma-cology (Autonomic pharma-cology of urogenital tract)
Martin Michel is a physician trained in experimental
and clinical pharmacology in Essen (Germany)
and San Diego (California). He is currently the
Global Head of Product and Pipeline Scientific
Support at Boehringer Ingelheim. Previously,
he headed the Nephrology and Hypertension
Research Laboratory in Essen (1993-2002)
and the Department of Pharmacology &
Pharmacotherapy at the University of Amsterdam
(2003-2011).
He has published more than 400 scientific articles,
is the Editor-in-Chief of Naunyn-Schmiedeberg’s
Archives of Pharmacology and also serves on the
board of many pharmacological, physiological
pharmacology socie-
December 2013
13
and urological journals. His research focuses on urogenital and
cardiovascular pharmacology.
Simon Maxwell Challenges in training tommorow’s prescribers
Simon Maxwell MD PhD FRCP FRCPE FBPharmacolS FHEA
is Professor of Student Learning/Clinical Pharmacology and
Director of Clinical Pharmacology & Therapeutics teaching at the
University of Edinburgh. He has made tremendous headway in
developing e-Learning strategies to support education in this area
and is currently the clinical lead for the Prescribe project, a joint
collaboration between the Department of Health, Medical Schools
Council (MSC) and British Pharmacological Society to deliver a
national eLearning solution to develop safe and effective prescribing
amongst UK medical students. His clinical responsibilities include
supervision of acute medical admissions and the management of
outpatients at increased cardiovascular risk. He is extremely active
in the industry on a global level and chairs a number of relevant
committees and associations.
Bruce McEwan The neurobiological effects of stress
Bruce McEwen PhD is the Professor of Neuroscience and runs the
Laboratory of Neuroendocrinology at Rockefeller University. His lab is
at the forefront of research on the impact of stress hormones on the
brain. He career as a neuroscientist and neuroendocrinologist spans
many years. Prof McEwen’s first paper was published in 1964, and
between then and now, he has published more than 700 papers. His
current research focuses on stress effects on amygdala and prefrontal
cortex, as well as hippocampus, and his laboratory also investigates
sex hormone effects and sex differences in these brain regions. He
is a member of the US National Academy of Sciences, the Institute
of Medicine, and the American Academy of Arts and Sciences. He
is also a member of the National Council on the Developing Child
which focuses on healthy brain development. He is the co-author of
two books for the lay audience and the recipient of numerous awards.
Salvador Moncada Cardiovascular pharmacology
Salvador Moncada MD, PhD and his research
influence have had major global impact, as
shown by his standing in the international citation indexes and his
acknowledgement as the most cited UK scientist in biomedicine
in the 1990s. In 2010 he received a knighthood from Her Majesty,
the Queen in recognition of his services to science. He spent two
decades leading various ground-breaking research projects at the
Wellcome Research Laboratories. In 1996, Prof Moncada moved
to University College, London to establish and direct the Wolfson
Institute for Biomedical Research. At the invitation of the Spanish
Government, between 1999 and 2004 he conceived, designed and
developed the Centro Nacional de Investigaciones Cardiovasculares
(CNIC) in Madrid. In recent years, an interest in glycolysis research
has had significant implications for the understanding of normal and
abnormal cell proliferation, for example, in cancer.
Richard Neubig Signal transduction in therapeutics
Richard Neubig MD PhD recently became
Professor and Chair of Pharmacology and
Toxicology at Michigan State University. Prior to that he was a faculty
member at the University of Michigan from 1983, where he served as
Professor of Pharmacology, Associate Professor of Internal Medicine,
and director of the Center for the Discovery of New Medicines. He is also
the 2013 - 14 President of the American Society for Pharmacology and
Experimental Therapeutics (ASPET). His research deals with G proteins
and their receptors – by exploiting these mechanisms, his group has
identified new drug candidates that may have utility in cancer, fibrosis,
and mental depression.
He has demonstrated a significant commitment to education through
his activities at ASPET and the Nomenclature Committee of the Inter-
national Union of Basic and Clinical Pharmacology (NC-IUPHAR).
Clive Ondari Medicine selection in emerging economies
Clive Ondari PhD, MBA, BSc is the coordinator of Medicine
Access and Rational Use (MAR) and Essential Medicines and
Pharmaceutical Policies (EMP) at the World Health Organization.
His work incorporates guidance on national medicines policies,
selection, supplies management, good governance and rational
use of medicines. Dr Ondari has over 20 years of experience in
Continued on page 14...
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pharmaceutical policies and programmes, having
worked for the Government of Kenya and WHO on
various assignments.
He started his career in academia and regulatory
affairs in Kenya where he was Associate Professor
of Pharmaceutics and Head of Department at the
University of Nairobi and Chairman of the Pharmacy
Board (Committee on Registration of Medicines) for
over 10 years.
His commitment to improve access to medicines
is extensive. He has led activities in the evaluation
of the quality of malaria medications in developing
countries and coordinated the development of the
first comprehensive WHO guidelines on malaria
treatment.
Munir Pirmohamed Drug safety science
Munir Pirmohamed is
currently David Weatherall Chair in Medicine at the
University of Liverpool, and a Consultant Physician
at the Royal Liverpool University Hospital. He also
holds the only NHS Chair of Pharmacogenetics
in the UK, and is Deputy Director of the MRC.
Centre for Drug Safety Sciences, and Director of
the Wolfson Centre for Personalised Medicine,
amongst other titles.
His research focuses on individual variability in
drug response, both safety and efficacy, with a
view to evaluating the mechanisms, and identifying
strategies to personalise medicines to optimise
drug efficacy and minimise toxicity.
The translational research agenda has been
strengthened through the award of the MRC
Clinical Pharmacology training scheme for clinical
fellows. Prof Pirmohamed has received a number
of honours, most recently, the William Withering
Medal from the Royal College of Physicians
and the IPIT award for Public Service from the
University of North Carolina in the US.
Pantangi Rangachari Basic pharmacology education
Pantangi Rangachari
MBBS, PhD is a Professor (Emeritus) of
Medicine at McMaster University, Canada. He
has taught students from diverse programmes
(undergraduate science, liberal arts, nursing,
medicine, physiotherapy and pharmacy). His
courses have linked toxicology with creative
writing, signal transduction of taste receptors with
anthropology, and his students have explored the
antecedents of medical technology.
He is Vice-Chair of the IUPHAR Education Section
and is on the editorial board of Advances in
Physiology Education, and Biochemistry and
Molecular Biology Education (BAMBED). He has
received the 3M National Teaching Fellowship,
the Ontario Confederation of University Faculty
Associations (OCUFA) award, the President’s
Award for Excellence in Teaching from McMaster
University, as well as McMaster Students Union
Teaching awards. He was the Claude Bernard
Lecturer of the American Physiological Society for
2011. He has published over 110 refereed papers
and co-authored three books on both experimental
sciences as well as education.
Dan Roden Moving pharmacog-enomic discovery to implementation
Dan Roden, MD, is Principal
Investigator for the Vanderbilt sites of the National
Institutes of Health’s Pharmacogenomics Research
Network and the National Human Genome Research
Institute’s Electronic Medical Records and Genomics
Network. He directs BioVU, the Vanderbilt DNA
databank that currently links DNA samples from
more than 135,000 patients to de-identify electronic
medical records. Prof Roden’s career-long focus
has been studies of the clinical, genetic, cellular
and molecular basis of arrhythmia susceptibility and
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December 2013
15Continued on page 16...
variability responses to arrhythmia therapies, and he is widely recognised
for his expertise in drug-induced arrhythmias. Over the last 10 years,
he has also led Vanderbilt’s broader efforts in pharmacogenomics
discovery and implementation. Prof Roden has received the Leon
Goldberg Young Investigator Award and the Rawls Palmer Progress in
Science Award from the American Society for Clinical Pharmacology
and Therapeutics and the Distinguished Scientist Award from both the
Heart Rhythm Society and the American Heart Association.
Stephen Stahl Mechanism of action of the atyp-ical antipsychotics in psychosis and mood disorders: The pines, the dones, two pips and a rip
Stephen Stahl MD PhD is Adjunct Professor of Psychiatry at the
University of California, San Diego and Honorary Visiting Senior
Fellow, University of Cambridge, UK. He has held faculty positions
at Stanford University, the University of California, Los Angeles, the
Institute of Psychiatry London and the Institute of Neurology London.
Prof Stahl was also Executive Director of Clinical Neurosciences
at the Merck Neuroscience Research Center in the UK for several
years.
His major interests are dedicated to producing and disseminating
educational information about diseases and their treatment in
psychiatry and neurology with a special emphasis on multimedia, the
Internet and teaching how to teach. Prof Stahl is the author of over 425
articles and more than 1500 scientific presentations and abstracts.
He is an internationally recognised clinician, researcher and teacher
in psychiatry with subspecialty expertise in psychopharmacology.
Prof Stahl has also written 25 books, including a best-selling textbook
and clinical manual.
Brian Strom Use of pharmacoepidemiology to
Brian Strom MD, MPH is Professor of
Public Health and Preventive Medicine,
the Executive Vice Dean of Institutional Affairs, and Professor of
Biostatistics & Epidemiology, Professor of Medicine, and Professor
of Pharmacology, all at the Perelman School of Medicine of the
University of Pennsylvania.
The Center for Clinical Epidemiology and Biostatistics that he
created at Penn includes over 550 faculty, research and support
staff, and trainees. At the time Prof Strom stepped down, CCEB
research received nearly $49 million/year in extramural support. Its
total budget was approximately $67 million.
More than 560 clinicians have been trained or are in training
through the CCEB’s Master of Science in Clinical Epidemiology
degree programme, which he founded. In this process, Prof Strom
has become a leader in the rigorous formal training of clinical
researchers. He is probably best known as a founder of the field
of pharmacoepidemiology, and a pioneer in using large automated
databases for research.
Ronald Taylor Monoclonal antibodies in cancer
Ronald Taylor PhD is Professor of Biochemistry
at the University of Virginia School of Medicine, a position he has
held since 1983.
He completed his PhD in Physical Chemistry at Princeton University
and his postdoctoral research at the University of Minnesota. For
almost 25 years, Prof Taylor’s laboratory has investigated monoclonal
antibodies (mAbs) and their applications in clinical medicine, with
special emphasis on the role of complement and other immune
effector functions in mAb-based immunotherapies of cancer. He has
published 170 papers, including 8 patents,
and serves on the editorial boards of several
journals, including the Journal of Immunology.
Nicholas White Antimalarial pharmacology
Nicholas White is currently a Professor of Tropical Medicine at
the Faculty of Tropical Medicine, Mahidol University and Oxford
University, and is also a Consultant Physician at the John Radcliffe
Hospital, Oxford, UK. He chairs the Wellcome Trust Tropical Medicine
Research Programme in Southeast Asia, and the Oxford Tropical
Medicine Network (encompassing research groups in Thailand,
Vietnam, Laos, Kenya and The Gambia). Prof White has lived and
worked for more than half of his life in Thailand, one of the leading
countries in malaria research, and has been instrumental in this
continuing effort. He is the recipient of the Prince Mahidol award
(2011) which is the highest academic recognition in Thailand.
His principal research interests are malaria, particularly the
pathophysiology and treatment of malaria, and also other severe
tropical infectious diseases. He has published over 880 scientific
papers and over 40 book chapters.
study the effects of pharma-ceuticals
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Monday 14 July 2014 10:30 – 12:00Track 1 - Pharmacology of novel tuberculosis
regimens
Chair: Tawanda Gumbo
Emerging antituberculosis agents: Bedaquiline,
Delamanid, PA824 - Kelly Dooley
The role of Rifamycins and Fluoroquinolones in
tuberculosis - Helen McIlleron
Optimising drug combinations and doses -
Tawanda Gumbo
Monday 14 July 2014 10:30 – 12:00Track 2 - New drug research and development for
Alzheimer’s disease
Chair: Lin Li
Dl-PHPB, a novel drug candidate for Alzheimer’s
disease - Xiaoliang Wang
Beneficial effects of huperzine A on mitochondrial
dysfunction and potential molecular mechanisms
HaiYan Zhang
Combinational therapeutic targets for Alzheimer’s
disease based on network pharmacology - Wenxia
Zhou
Multitarget strategy and new drug development of
traditional Chinese medicine to treat Alzheimer’s
disease - Lin Li
Monday 14 July 2014 10:30 – 12:00Track 3 - Natural Products: Neuro-Metabolic-Vascular
Mechanisms
Chair: Yu Huang
Exploration for discovery of anti-ischemic stroke
drugs targeting the neurovascular unit based on mu
- Guanhua Du
Intervention of vicious cycle between liver disease
and metabolic dysfunction by natural products -
Sang-geon Kim
Natural products, cholesterol and cardiovascular
diseases - Zhen Yu Chen
Potential of natural products to protect the vascular
system in health and diseases - Valérie Schini-Kerth
Monday 14 July 2014 10:30 – 12:00Track 4 - Therapeutic monoclonal antibodies in oncology
Chair: Clive Zent
Mechanisms of action of unconjugated mAb -
Ronald Taylor
Unconjugated mAb therapy in B cell malignancies -
Clive Zent
Conjugated mAb - Stephen Ansell
BiTE antibody constructs - Patrick Baeuerle
Monday 14 July 2014 10:30 – 12:00Track 5 - What every pharmacologist should know
about children
Chair: Kalle Hoppu
Children’s access to medicines - Therapeutic
orphans being adopted? - Kalle Hoppu
Developmental pharmacology before birth - Shinya Ito
Pharmacology of the newborn - John Van Den Anker
Developmental pharmacology in infants and children
- Gregory Kearns
Drug safety in children - Shalini Sri Ranganathan
Monday 14 July 2014 10:30 – 12:00Track 6 - Epigenetic regulation of drug metabolizing
enzymes and transporters
Chair: Ingolf Cascorbi
DNA methylation in the regulation of drug metabolism
and transport - Magnus Ingelman-Sundberg
Role of microRNAs in the regulation of drug
metabolism and disposition - Ingolf Cascorbi
Toxicological implications of modulation of gene
expression by microRNAs - Igor Pogribny
Monday 14 July 2014 13:30 – 15:00Track 1 - Antibiotic resistance
Chair: Marc Mendelson
The global spread of multi-drug resistant Gram-
negative bacteria - Adrian Brink
Novel targets for the antibiotic pipeline - Timothy Walsh
Limiting the use of antibiotics in primary care -
Christopher Butler
December 2013
17Continued on page 18...
Monday 14 July 2014 13:30 – 15:00Track 2 - New targets for stress
Chair: Maurizio Popoli
Disrupted circadian clocks as modulators of
resilience to stress - Ilia Karatsoreos
Neurobiological mechanisms linking stress and
high trait anxiety with depression - Carmen Sandi
The impact of stress on glutamate
transmission and neuronal architecture: A key
to pathophysiology and treatment of mood
and anxiety disorders - Maurizio Popoli
Focusing on the “golden hours”: Preclinical
and clinical insights on immediate intervention
in stress related disorders - Joseph Zohar
Monday 14 July 2014 13:30 – 15:00Track 3 - Therapeutic targets for treating/
preventing insulin resistance and
cardiometabolic complications
Chair: Ramaroson Andriantsitohaina
Exercise, miokines and inter-organ cross-
talk - Juergen Eckel
Mechanisms underlying the initiation,
progression and potential regression of
renal and diabetic complications -
Catherine Godson
Impact of endogenous resolution on
vascular inflammation: a key role for the
Annexin A1 pathway - Mauro Perretti
Adipokines and cardiometabolic
complications - Concha Peiro
Improving endothelial function in type 2
diabetes - Ismael Laher
Microparticles as new players in insulin
resistance and cardiovascular complications
- Ramaroson Andriantsitohaina
Monday 14 July 2014 13:30 – 15:00Track 4 - Targeted small molecule therapy in
oncology
Chair: Thomas Witzig
Targeting the mTOR pathway in hematological
malignancies - Thomas Witzig
Targeting the mTOR pathway in solid tumors -
Robert Maki
Targeting JAK2 and ABL in myeloid
malignancies - Animesh Pardanani
Immunomodulatory derivatives (IMIDs) -
Grzegorz Nowakowski
Monday 14 July 2014 13:30 – 15:00Track 5 - Communicating with the public and
the policy community
Chair: Donald Singer
Communicating about NICE, drugs and the
4th hurdle - David Haslam
Engaging the public and policy community
about advances in personalized medicines -
Katherine Johansen Taber
Raising the profile of pharmacology through
public engagement - Katharine Richardson
Monday 14 July 2014 13:30 – 15:00Track 6 - Orphan G protein-coupled receptors-
What are the new ligand and new drug
targets?
Chair: Anthony Davenport
Orphan G protein-coupled receptors: what
are the remaining druggable targets? - Adam
Pawson
Therapeutic potential of biased apelin agonists
and antagonists - Anthony Davenport
From AIDS to atherosclerosis: Chemokines,
CCR5 and maraviroc - Janet Maguire
Role of cannabinoid-related receptors (GPR55,
GPR18 and GPR119) in inflammation, satiety
and obesity - Stephen Alexander
Monday 14 July 2014 15:30 – 17:00Track 1 - Novel therapeutic strategies in HIV
Chair: Gary Maartens
Penetration of antiretrovirals into sanctuary
sites - Gary Maartens
Drug targets for curing HIV - Daria Hazuda
Interactions between antiretrovirals and
complementary medicines - Adriana Andrade
Monday 14 July 2014 15:30 – 17:00Track 2 - Calcium signaling in brain diseases
Chair: Masamitsu Iino
Mitochondrial Ca2+ signalling - Rosario Rizzuto
Presenilins, neuronal calcium signaling and
Alzheimer’s disease - Iiya Bezprozvanny
Nitric oxide-dependent calcium signaling in
ischemic brain injury - Masamitsu Iino
Monday 14 July 2014 15:30 – 17:00Track 3 - Advances in reproductive
pharmacology
Chair: Yan Zhu
Advances in contraceptives - Asgi Fazleabas
Prospective of contraceptives and its application
of adjuvant therapy in China - Yan Zhu
Epigenomic reprogramming of the developing
reproductive tract and disease susceptibility in
adulthood - To Be Advised
Mifepristone in combination with
prostaglandins for termination of 10-16 weeks’
gestation: A systematic review - Linan Cheng
The state of hormonal contraception today:
Benefits and risks of hormonal contraceptives,
combined estrogen and progestin
contraceptives - Lee P Shulman
Monday 14 July 2014 15:30 – 17:00Track 4 - Targeting B cell signaling in oncology
Chair: Adrian Wiestner
Signaling through the B cell receptor:
Targetable molecules - Paolo Ghia
Targeting the B cell receptor pathway in B cell
malignancies - Adrian Wiestner
Targeting the proteasome - Irene Ghobrial
Survival signals: Targeting the gatekeepers of
apoptosis - Andrew Roberts
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Monday 14 July 2014 15:30 – 17:00Track 5 - 2020 Vision for pharmacology education
(IUPHAR Education Section Symposium)
Chair: Simon Maxwell
Pharmacology teaching, learning and assessment in
the ‘e-space’: Strategies and implementation - David
Dewhurst
Developing an online education resource in
pharmacology and therapeutics for medical students
- Robert Likic
Flipping the classroom: Using technology to build
core learning structures in clinical pharmacology -
Shirra Moch
e-Learning 2.0: The Teaching Resource Centre as a
tool for integrative pharmacology and therapeutics -
Robert Rissman
Delivering a national strategy for e-Assessment
in clinical pharmacology and prescribing - Simon
Maxwell
Influences on the uptake of technology for teaching
and assessment of pharmacology? Can IUPHAR
help? - Elizabeth Davis
Monday 14 July 2014 15:30 – 17:00Track 6 - Mathematical modelling and computer
simulation: Applications to healthcare from cradle
to clinic
Chair: Paolo Denti
Clinical Pharmacology = Disease Progression +
Drug Action - Nick Holford
From drug development to the clinic, anti-epileptic
drugs - Raymond Miller
M&S for Decision making in oncology translational
research - Paolo Vicini
The Gates Foundation approach to apply M&S to
African health challenges - Steven Kern
Pharmacometrics in HIV, TB, and malaria: Dose
optimisation for neglected populations - Paolo Denti
Tuesday 15 July 2014 10:30 – 12:00Track 1 - New drugs for neglected infectious
diseases
Chair: Mauro Teixeira
Developing new drugs for malaria - Tim Wells
New drugs for tuberculosis and dengue - Theirry
Diagana
Developing new compounds against schistosomiasis
- Francois Noel
Tuesday 15 July 2014 10:30 – 12:00Track 2 - Protein S-ntrosylation as a therapeutic
target
Chair: Takashi Uehara
Nitric oxide signaling in liver diseases - Yasuko Iwakiri
Aberrant protein S-Nitrosylation in neurodegenerative
disorders - Tomohiro Nakamura
Covalent modification of H-Ras by nitric oxide-
derived reactive species underlies development of
chronic heart failure - Motohiro Nishida
Mechanism of nitric oxide-induced endoplasmic
reticulum stress - Takashi Uehara
Tuesday 15 July 2014 10:30 – 12:00Track 3 - Obesity: Basic and clinical pathophysiology
and pharmacology
Chair: Ismael Laher
The obesity landscape and reproduction: views from
animal and human studies - Lucilla Poston
Developmental origins of pediatric obesity-
Challenges and opportunities - Dana Dabelea
How the gut talks to the brain: Lessons for new anti-
obesity drugs - Carel Le Roux
How can we pharmacologically treat obesity? -
Nicholas Finer
Tuesday 15 July 2014 10:30 – 12:00Track 4 - TGFB in radiation biology and therapy
Chair: Beverly Teicher
Does microenvironment contribute to the etiology
of ER-negative breast cancer? - Mary Helen
Barcellos-Hoff
Role of radiation-induced TGFß signaling in cancer
therapy - Mansoor Ahmed
Inhibition of PARP-1 increases the radiosensitivity of
Continued on page 19...
December 2013
19Continued on page 20...
lung tumors - Ian Stratford
Role of the VEGF/VEGFR axis in cancer
biology and therapy - Giovanni Melillo
Tuesday 15 July 2014 10:30 – 12:00Track 5 - IUPHAR Natural Products Section
Chair: Yong-Xiang Zhang
Efficacy and safety of bioactive
phytochemicals is influenced by their ability
to interact with multiple target sites - Anwar-ul-
Hassan Gilani
Pharmacological study of the active
polysaccharides isolated from traditional
Chinese medicines - Yong-Xiang Zhang
Traditional Chinese and Kampo medicines
targeting diabetes- and aging-induced
cognitive and emotional deficits:
Neuropharmacological evidence from
Chotosan (Gouteng-san) - Matsumoto Kinzo
Development of anti-malarial drug artesunate
as an anti-inflammatory agent for allergic
asthma and COPD - Wai Shiu Fred Wong
The marine pharmaceutical pipeline - Alejandro
Mayer
Tuesday 15 July 2014 10:30 – 12:00Track 6 - Innovations in drug therapies: The
future is now
Chair: Gene Colice
New ways to treat bacterial infections - Peter
Taylor
New therapeutic approaches for treating
pulmonary disease - Gene Colice
RNA interference (RNAi) a new therapeutic
approach: From concept to human proof-of-
concept - Ronit Satchi-Fainaro
Tuesday 15 July 2014 13:30 – 15:00Track 1 - Pharmacogenetics in infectious
diseases
Chair: Ann Daly
Pharmacogenetics and safety of antimalarial
drugs - Jose Gil
Pharmacogenetics and safety of
antituberculosis drugs - Adalberto Santos
Pharmacogenetics and safety of antiretroviral
drugs - Eleni Aklillu
Tuesday 15 July 2014 13:30 – 15:00Track 2 - Optimizing anti-epilepsy drug
discovery
Chair: Michele Simonato
Defining the clinical “gaps to care” and the
“opportunities” to develop new treatments for
epilepsy - Jacqueline French
Technical and methodological issues - Aristea
Galanopoulou
Development of anti-epileptogenic therapies -
Asla Pitkanen
Use of biomarkers and surrogate endpoints.
- Jerome Engel
Tuesday 15 July 2014 13:30 – 15:00Track 3 - Renin-angiotensin system
pharmacology revisited
Chair: Jan Danser
Blockade of prorenin, renin and the (pro)renin
receptor: too much of a good thing? - Jan
Danser
Novel domain-selective ACE inhibitors:
Antihypertensives or antifibrotics? - Edward
Sturrock
The AT2 receptor as a drug target: Should
we stimulate it or block it? - Ulriche Muscha
Steckelings
How to activate the ACE2-angiotensin-(1-7)-
Mas axis - Robson Santos
Tuesday 15 July 2014 13:30 – 15:00Track 4 - DNA repair and topoisomerase
inhibitors in oncology
Chair: Beverly Teicher
Drugging topoisomerases: Lessons and
challenges - Yves Pommier
PARP and CHK inhibitors as anticancer
therapeutics - Antony Oliver
Topic to be advised - Mary-Ann Bjornsti
Tuesday 15 July 2014 13:30 – 15:00Track 5 - Internet-based solutions to alleviate
shortages of pharmacology faculty in
developing countries
Chair: Leszek Wojnowski
Developing successful e-Learning that counts
- Simon Maxwell
Question writing for any occasion: Use of
questions in assessment and learning - John
Szarek
Hardware and software needs for
enhancement of medical education in
Tanzania - John Bartlett
Current status of the KCMUCO pharmacology
curriculum project - Leszek Wojnowski
Pe(E)r-Learning: the potential of peer-teaching
to create high quality e-Learning content -
Antonio Sarikas
Tuesday 15 July 2014 13:30 – 15:00Track 6 - Plants and animal toxins as sources
of new therapeutic drugs
Chair: Yara Cury
Molecular mechanisms involved in
antinociception induced by crotalphine,
peptide from Crotalus venom - Yara Cury
Antimalarial activity of medicinal plants native
to or naturalized in South Africa - Matsabisa
Motlalepula
Anticancer compounds from marine
microorganisms collected at Brazilian tropical
seas - Leticia Costa-Lotufo
Effect of animal venom peptides on acid:
Sensing ion channels and pain control -
Ladzdunski Michel
PharmacologyInternational
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Better Medicines through Global Education and
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Tuesday 15 July 2014 13:30 – 15:00Track 7 - Structural basis for ion channel
Structural basis for function and pharmacology of
voltage-gated sodium and calcium channels -
William Catterall
Structure basis for drug action on the cys-loop
family of receptors - Jean-Pierre Corringer
Outer structures in ionotropic glutamate
receptors as drug targets - Lonnie Wollmuth
Tuesday 15 July 2014 15:30 – 17:00Track 1 - Recent breakthroughs in malaria treatment
Chair: Karen Barnes
Tuesday 15 July 2014 15:30 – 17:00Track 2 - The addictive brain through different
receptor subtypes
Chair: Filippo Drago
Acute cannabinoids impair working memory through
astroglial CB1 receptor modulation of hippocampal
L - Giovanni Marsicano
Dopamine D3 receptors and alcohol addiction - Gian
Marco Leggio
Association between nicotinic acetylcholine receptor
single nucleotide polymorphisms and smoking
Marcus Munafò
Blockade of dopamine D4 receptors attenuates
reinstatement of extinguished nicotine-seeking
behaviour - Bernard Le Foll
Tuesday 15 July 2014 15:30 – 17:00Track 3 - Aspirin, the wonder drug: Keeping a balance
between its great therapeutic benefits & its GI toxicity
Chair: Lenard Lichtenberger
Role of platelets and PC-aspirin - Lenard Lichtenberger
COX-1/COX-2 inhibition, role of neutrophils and H2S-
aspirin - John Wallace
Targeted aspirin therapy in PIK3CA colorectal cancer
- Andrew Chan
Aspirin and NF-kappaB pathway and melanoma -
Angela Ianaro
Tuesday 15 July 2014 15:30 – 17:00Track 4 - Sarcoma genetics and targeted therapeutics
Chair: Beverly Teicher
Tageted kinase inhibitors for treatment of sarcoma
- Gary Schwartz
Screening of pediatric and adult sarcoma cell
lines reveals novel patterns of sensitivity toward
approved oncology drugs and investigational
agents - Beverly Teicher
Genetic and epigenetic changes in sarcoma - Paul
Meltzer
Molecular characteristics and therapies for
Liposarcoma - Samuel Singer
Tuesday 15 July 2014 15:30 – 17:00Track 5 - Regulatory challenges in herbal and
traditional medicines
Chair: Philip Routledge
Efficacy and safety of herbal and traditional
medicines: Regulatory implications - Philip Routledge
Purity of herbal medicines: Implications for regulation
- Michael Heinrich
Concomitant use of herbal/traditional and
conventional medicines - Alvaro Viljoen
Regulatory approaches to herbal and traditional
medicines: The contribution of education - Anthony
J Smith
Tuesday 15 July 2014 15:30 – 17:00Track 6 - NC-IUPHAR and the Guide to Pharmacology
Chairs: Michael Spedding & Colin Dollery
Introduction to NC-IUPHAR - Colin Dollery
NC-IUPHAR: How two decades of controversy help
resolve drug discovery - Michael Spedding
IUPHAR-DB, GRAC and the Guide to Pharmacology
- Adam Pawson
Analyzing the drug targets in the human genome -
Chris Southan
The IUPHAR educational website - Simon Maxwell
pharmacology
Chair: William Catterall
behaviour -
Continued on page 21...
December 2013
21
Wednesday 16 July 2014 10:30 – 12:00Track 1 - Advances in antiviral therapy
Chair: Marc Mendelson
Novel targets and therapeutic management of
hepatitis C infection - Graham Foster
The influenza antiviral pipeline - Fred Hayden
Interference strategies for treatment of viral
infections - Ben Berkhout
Wednesday 16 July 2014 10:30 – 12:00Track 2 - Rethinking mood therapeutics: Novel
pharmacological approaches for anxiety and
depression
Chair: Nicolas Singewald
Rescue of impaired fear extinction by targeting
epigenetic mechanisms in a genetic mouse
model - Nicolas Singewald
Translational support of a role of
endocannabinoids in anxiety and its treatment
- Andrew Holmes
Revising antidepressant therapy: From
serotonin to glutamate - Greger Wegener
Behavioural and biological validation of an
animal model of obsessive-compulsive
disorder (OCD) - Brian Harvey
microRNAs as novel therapeutic targets for
anxiety and depression - John Cryan
Wednesday 16 July 2014 10:30 – 12:00Track 3 - Manipulation of gut microbiome as
a treatment strategy for gastrointestinal and
metabolic disorders
Chair: Yvette Tache
Intestinal microbiota transfer from lean donors
increases insulin sensitivity in metabolic
syndrome - Max Nieuwdorp
Probiotics deliver neuroactive compounds:
Microbial endocrinology in the design and
use of probiotics - Mark Lyte
Intestinal microbiota in functional bowel
disorders - Kashyap Purna
Modulation of stress-related visceral pain by
probiotic - Yvette Tache
Wednesday 16 July 2014 10:30 – 12:00Track 4 - (*IUPHAR-Clin Div Update in geriatric
pharmacology) Optimal prescribing in older
patients: The challenge of multiple comorbid
conditions and polypharmacy
Chair: Darrell Abernethy
Multiple comorbid conditions and disease-
based treatment guidelines: The therapeutic
dilemma for older persons with geriatric
syndromes - Sarah Hilmer
Methods to assess drug burden and
Ppolypharmacy - Petra Thürmann
Deprescribing to limit polypharmacy: The
evidence base - David Le Couteur
Effects of new drugs in older patients: What
is known at the time of drug approval? - Darrell
Abernethy
Wednesday 16 July 2014 10:30 – 12:00Track 5 - Managed introduction of new
medicines
Chair: Lars Gustafsson
Challenges and developments in Vietnam -
Nghiem Tran Dung
Developments and challenges in South Africa:
Focus on non-communicable diseases, HIV and
cancer - Ilse Truter
Developments and challenges in Brazil,
including neglected diseases - Bethânia de
Araújo Almeida
The national Scottish partnership model
of rapid HTA of new medicines: 10 years
experience - Angela Timoney
Suggested models to introduce new
medicines: Building on experience with new
oral anticoagulants - Brian Godman
Wednesday 16 July 2014 10:30 – 12:00Track 6 - Evolution, sport and modern diseases
Chairs: Michael Spedding & Ian McGrath
Evolution and running - Tim Noakes
Does sport reveal the end of a long range
physiological evolution? - Jean-François Toussaint
Improving muscle mass and function in older
adults: Understanding the mechanisims of
sarcopenia - Paul Greenhaff
Brain development and evolution:
Mechanisms, circuits, and susceptibility to
disease - Michael Spedding
Wednesday 16 July 2014 13:30 – 15:00Track 1 - Vaccine development
Chair: Marc Mendelson
Developments in dengue vaccines - Amadou Sall
New targets for influenza vaccines - Albert
Osterhaus
Progress towards a new tuberculosis vaccine -
Willem Hanekom
Maternal immunization - Shabir Madhi
Wednesday 16 July 2014 13:30 – 15:00Track 2 - Phosphodiesterase 4 inhibitors as
novel anti-inflammatory drugs
Chair: Eeva Moilanen
Wednesday 16 July 2014 13:30 – 15:00Track 3 - Neuroendocrine regulation of
gastrointestinal protection: Central and
peripheral pathways
Chair: Klara Gyires
Brainstem neuropeptides induce vagally
mediated gastroprotection: Role of
prostaglandins, NO and CGRP - Yvette Tache
Interactions between neuropeptides in
gastroprotection - Klara Gyires
Contribution the hypothalamic-pituitary:
Adrenocortical axis hormones to
gastroprotection - Ludmila Filaretova
Brain-gut axis in the mechanism of gastric
protection and ulcer healing - Tomasz
Brzozowski
Continued on page 22...
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Wednesday 16 July 2014 13:30 – 15:00Track 4 - Controversies in essential medicines
Chair: Clive Ondari
Selecting medicines for off-label indications: A global
Andy Gray
Selecting essential medicines for cancer: The EMLc
approach - Clive Ondari
Managing essential medicines in rare/neglected
diseases - Elizabeth Mathai
Wednesday 16 July 2014 13:30 – 15:00Track 5 - Clinical pharmacometrics: Application to
target concentration intervention
Chair: Nick Holford
Safe and effective variability: A quantitative approach
to guide rational dose individualization - Nick Holford
TCIworks: Challenges in introducing TCI into clinical
practice - Carl Kirkpatrick
Nextdose: A web based collaborative tool for target
concentration intervention - Sam Holford
The Drug Dashboard: Integrating medical
informatics with dosing decisions - Jeff Barrett
Wednesday 16 July 201413:30 – 15:00Track 6 - Evaluating drug-drug interactions with
therapeutic proteins
Chair: Honghui Zhou
In vitro / preclinical studies and mechanisms for
drug-drug interactions with therapeutic proteins -
Frank-Peter Thiel
Clinical evaluations of drug-drug interactions with
therapeutic proteins - Honghui Zhou
Drug-drug interactions with therapeutic proteins:
Industrial and regulatory perspectives - Honghui Zhou
Wednesday 16 July 2014 15:30 – 17:00Track 1 - Inflammation and allergy: New therapeutic
avenues
Chair: Francesca Levi-Schaffer
Therapeutic strategies for allergic diseases based
on modern genomics - Marc Rothenberg
CRTH2 antagonism: A new therapeutic principle in
allergic diseases - Hans-Uwe Simon
Inhibitory receptors on mast cells and eosinophils
as new targets for anti-allergic therapy - Francesca
Levi-Schaffer
Specialized pro-resolving mediators: Agonists for
resolution of lung inflammation and injury - Bruce Levy
Wednesday 16 July 2014 15:30 – 17:00Track 2 - New approaches for non-neuronal brain
diseases
Chair: Yuji Ikegaya
A role for inflammation-related molecules in
behavioral depression induced by repeated stress -
Tomoyuki Furuyashiki
Pathophysiology of neuro-glio-vascular dynamics -
Yuji Ikegaya
New approach for evaluating the drug effect in the
cerebrovascular disorders - Toshiaki Kume
Non-cell-autonomous modulation of neuropathic
pain by microglia - Makoto Tsuda
Wednesday 16 July 2014 15:30 – 17:00Track 3 - Lipid modifying strategies: Needs beyond
statins
Chair: Gonzalo Calvo-Rojas
Drug targets for lipid modyfying strategies -
Fernando Civeira
Animal models in hyperlipidaemia and
arteriosclerosis - Paul Quax
Clinical development strategies: From primary
prevention to orphan indications - Tabassome Simon
Statin treatment: Goals and failures - Marie-Louise
Ovesjö
Wednesday 16 July 2014 15:30 – 17:00Track 4 - Problems with OTC analgesics
Chair: Kay Brune
OTC analgesics: Abuse in endurance sports
- Kay Brune
Second generation effects of paracetamol
- Gisa Tiegs
perspective -
Continued on page 23...
December 2013
23
Usage patterns and risks of OTC analgesics
- Nicholas Moore
Assessing multiple organ toxicity of
analgesics - Kim Rainsford
Wednesday 16 July 2014 15:30 – 17:00Track 5 - Global PGx-based personalized
medicine
Chair: Ingolf Cascorbi
The view from North America - Julie Johnson
The view from South America - Guilherme
Suarez-Kurtz
The view from Africa - Collen Masimirembwa
The view from Australia - Andrew Somogyi
The view from Europe - Ingolf Cascorbi
Global education in PGx - Adrian Llerena
Public health PGx - Vural Özdemir
Wednesday 16 July 2014 15:30 – 17:00Track 6 - Emerging Drug Targets
Chair: Richard Neubig
Plucking the high hanging fruit: Synthetic
Paramjit Arora
Allosteric targeting of protein-protein
interactions: RGS proteins in CNS therapeutics
Richard Neubig
Anti-apoptosis therapies in cancer - Simone Fulda
Thursday 17 July 2014 10:30 – 12:00Track 1 - Glucocorticoids: new insights into
mechanisms of action
Chair: Carlo Riccardi
The glococoticoid receptor: One gene many
offspring - John Cidlowski
Annexin-1 as a mediator of glucocorticoids
action - Rod Flower
Mechanisms of anti-inflammatory actions of
glucocorticoids: Role of GILZ - Carlo Riccardi
Thursday 17 July 2014 10:30 – 12:00Track 2 - Targeting the TRPA1 channel for pain
treatment
Chair: Pierangelo Geppetti
The roles of TRPA1 in pain, analgesia and
temperature regulation - Stuart Bevan
TRPA1 channels are neuronal sensors of
bacterial endotoxins - Felix Viana
The role of TRPA1 in chemotherapeutic-
induced peripheral neuropathy and migraine
hypersensitivity - Pierangelo Geppetti
Thursday 17 July 2014 10:30 – 12:00Track 3 - Hydrogen sulfide in GI health and
disease
Chair: John Wallace
The pharmacology of H2S - Hideo Kimura
H2S and inflammation of the GI tract - John
Wallace
H2S and resolution - Mauro Perretti
H2S in gastrointestinal nociception and pain -
Nathalie Vergnolle
Thursday 17 July 2014 10:30 – 12:00Track 4 - (*IUPHAR-Clin Div) Hot topics in
pharmacoeconomics
Chair: Suzanne Hill
Pharmaceutical pricing: What are the current
policy approaches for managing prices?
- Speaker to be advised
A tale of two molecules: Marketing and legal
influences on cost - Nicola Magrini
Compulsory licensing and HTA - Sripen
Tantivess
High cost challenges: Paying for
targeted therapies
Suzanne Hill
Thursday 17 July 2014 10:30 – 12:00Track 5 - Using clinical toxicology studies to
improve biomarkers and regulatory decisions
Chair: Michael Eddleston
Global overview of clinical toxicology -
Michael Eddleston
Using clinical toxicology to validate renal
injury biomarkers - Nicholas Buckley
Developing novel bomarkers for drug
induced liver injury - James Dear
Using pharmacovigilance to identify serious
adverse drug reactions - David Juurlink
Thursday 17 July 2014 10:30 – 12:00Track 6 - The role of drug transporters in inter-
individual variations in drug response
Chair: Matthias Schwab
Clinical pharmacogenetics of drug transporters
- Matthias Schwab
Role of drug transporters in drug exposure and
safety - Frans Russel
Integration of drug transporters as important
DMPK determinants in drug development -
Christoph Funk
Thursday 17 July 2014 13:30 – 15:00Track 1 - Immunopharmacology of the
systemic inflammatory response syndrome
Chair: Fernando Cunha
Triggering cell activation in sepsis vascular
dysfunction - Jamil Assreuy
Failure of neutrophil migration and the
pathogenesis of sepsis - Fernando Cunha
Systemic inflammatory response syndrome in
viral and protozoan infections - Mauro Teixeira
To be advised - Mauro Teixeira
Thursday 17 July 2014 13:30 – 15:00Track 2 - The nitric oxide-cGMP pathway in
neuropsychiatric illness: An update
Chair: Brian Harvey
Nitric oxide pathways in anxiety and stress-
related disorders - Greger Wegener
The role of nitric oxide synthase in
schizophrenia and impulsivity - Andreas Reif
-
strategies for targeting protein-protein
interactions in transcription -
Continued on page 24...
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NO and the modulation of behavioral responses to
stress: Implications for the neurobiology of depression
- Samia Joca
Thursday 17 July 201413:30 – 15:00Track 3 - Advances in GI pharmacology: New
approaches to upper and lower GI ulcers and
inflammation
Chair: Sandor Szabo
New challenges in GI pharmacology - Sandor Szabo
The promise and limitations of prostaglandins and
other gastroprotective drugs - Koji Takeuchi
The development of new, safe NSAIDs - Lenard
Lichtenberger
The clinical reality of preventing and treating
gastroduodenal ulcers - Gaetano Iaquinto
Current and potential future approaches to
inflammatory bowel diseases - Shunji Horie
Functional GI diseases are in dire need for effective
preventive and therapeutic interventions - Yvette Tache
Thursday 17 July 2014 13:30 – 15:00Track 4 - Can academic drug discovery deliver in
rare diseases?
Chair: Michael Spedding
MIPS: Integrating discovery, delivery and
development - Bill Charman
The Association Françaisecontre les Myopathies (AFM):
A 25 year revolution in rare diseases - Serge Braun
The Structural Genomics Consortium as a springboard
for discovery in epigenetics and kinases - Chas Bountra
Dundee Drug Discovery Unit: Diversity screening for
tropical diseases - David Gray
Thursday 17 July 2014 13:30 – 15:00Track 5 - IUTOX session on nanomedicines
Chair: Mary Gulumian
Nanomedicine for the treatment and diagnostic of
severe diseases - Patrick Couvreur
Nanotoxicology and nanomedicine - Mary Gulumian
Designer nanoparticles for therapeutic applications
- Samir Mitragotri
Electrochemical immuno(bio)sensors for the detection of
virus and disease-specific biomarkers - Philani Mashazi
Thursday 17 July 2014 13:30 – 15:00Track 6 - Understanding and predicting the extent of
drug-drug interactions
Chair: Geoffrey Tucker
In vitro characterisation of the inhibition of drug
metabolising enzymes - John Miners
In vitro-in vivo extrapolation of transporter-mediated
drug-drug interactions - Sibylle Neuhoff
Complex drug-drug interactions involving enzymes
and transporters - Geoffrey Tucker
Thursday 17 July 2014 15:30 – 17:00Track 1 - Immunobiologicals and chronic
inflammatory diseases
Chair: Francesca Levi-Schaffer
Targeting the chemokines system with antibodies and
potential for new drug development - To Be Advised
Targeting cytokines (IL-20, IL-21) with antibodies and
potential for new drug development - Ian Anhfelt-Ronne
Deciphering new targets for drug development in
chronic arthritis - Wim van den Berg
Thursday 17 July 2014 15:30 – 17:00Track 2 - Nitric oxide research reveals new ideas in
pharmacology
Chair: Arunabha Ray
Involvement of nitric oxide in the toxicodynamics of
drugs and xenobiotics - Kavita Gulati
Methylene blue: New light through old windows -
Brian Harvey
Regulation by nitric oxide (NO) of gender based
differences in stress-induced neurobehavioral and
immunological changes - Arunabha Ray
Continued on page 25...
December 2013
25
Thursday 17 July 2014 15:30 – 17:00Track 3 - Endothelium-dependent control of
vascular tone
Chair: Paul Vanhoutte
Complexity and regulation of NO signalling:
Recent developments - Brant Isakson
Endothelial cytochrome P450 and
lipoxygenases metabolites of arachidonic acid
in health and disease - William Campbell
Myo-endothelial gap junctions microdomains
and the control of vascular tone - Kim Dora
Endothelial dysfunction and inflammation:
new therapeutic targets for cardiovascular
diseases - Yu Huang
Thursday 17 July 2014 15:30 – 17:00Track 4 - (IUPHAR - Clin Div) Pharmaco-
epidemiology: At the cutting edge
Chair: Brian Strom
Using big data in comparative effectiveness
research - David Henry
Streamline randomised comparative
effectiveness - Thomas MacDonald
Comparative effectiveness research using a
national health insurance database in Taiwan -
Kin-Wei Arnold Chan
Use of a large simple trial design for
comparative effectiveness research: The
Ziprasidone Observational Study of Cardiac
Outcomes (ZODIAC) - Brian Strom
Thursday 17 July 2014 15:30 – 17:00Track 5 - The changing face of pediatric drug
development
Chair: Alison Bowers
The changing regulatory environment of
pediatric drug development - Alison Bowers
Pediatric drug development from the
sponsor’s perspective and bridging
approaches - Robert Kunka
Issues and solutions in pediatric clinical trials
- Kathryn Blake
Challenges for conducting early phase
pediatric PK trials: Overview of OTC and
pulmonary programs - Kenneth Kim
Thursday 17 July 2014 15:30 – 17:00Track 6 - Understanding drug induced liver
Injury: CYP450 and the immune system
Chair: Allan Rettie
Introduction to drug-induced liver injury: Types,
mechanisms, and salient characteristics -
James Lewis
Characterization of mechanisms of drug-
induced immune mediated liver injury - Jack
Uetrecht
Genetic predictors for drug-induced liver injury
(genome-wide association studies) - Ann Daly
Thursday 17 July 2014 13:30 – 15:00Track 7 - ORPHEUS PhD Standards: Bridging
PhD programs to promote global collaboration
Chair: Zdravko Lackovic
ORPHEUS-AMSE-WFME standards for PhD
education - Michael Mulvany
Do we need global standards for PhD
education - Zdravko Lackovic
Do we need international standards: China
position - Duan Liping
Do we need international standards: US
position - Joey Barnett
Do we need international standards: India
position - Arunabha Ray
Do we need international standards: South
Africa position - Christiaan Brink
Friday 18 July 2014 10:30 – 12:00Track 1 - Global HIV clinical pharmacology
capacity building and implementation research
Chair: Gene Morse
Ibadan University Clinical Pharmacology
Program - Fatai Fehintola
Harare International Pharmacology Specialty
Laboratory - Charles Maponga
University of Turin HIV Clinical
Pharmacogenomics Program - Giovanni Diperri
YRG Developmental Clinical Pharmacology
Program In India - Shanmugam Saravanan
Global Clinical Pharmacology Quality
Assurance & Quality Control Program - Robin
Difrancesco
New Fogarty HIV Research Training Programs
for Capacity Building - Gene Morse
Friday 18 July 2014 10:30 – 12:00Track 2 - (ASPET Symposium) Combination
medications as novel treatments for stimulant
addiction
Chair: Warren Bickel
Relapse vulnerability phenotypes are
suppressed by combined serotonin 5-HT2
receptor ligands - Kathryn Cunningham
Monoamines and cocaine medication
development in nonhuman primates -
Leonard Howell
Human laboratory evaluation of putative
combination pharmacotherapies for stimulant
use disorders - William Stoops
Extended-release mixed amphetamine salts
and topiramate for cocaine dependence: A
randomized controlled trial - Frances Levin
Friday 18 July 2014 10:30 – 12:00Track 3 - New challenges for the treatment of
diabetes mellitus
Chair: Manuel Vazquez-Carrera
Targeting inflammation to treat insulin
resistance - Manuel Vazquez-Carrera
Diabetes mellitus and vascular inflammation
old and new models for translational
research - Teresa Tejerina
Pros and cons about incretins: Are there any
choices beyond them? - Carmen Iglesias-Osma
Cardiovascular benefits of GLP-1 based
treatments for diabetes mellitus: Hopes or
realities - Manel Puig-Domingo
Continued on page 26...
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Better Medicines through Global Education and
Research
Congress Bursary GuidelinesObjectiveThe primary goal of the Congress Bursary is to
support young and established pharmacologists
from financially restricted environments and
who are actively involved in research, to attend
and participate in the WCP2014 Congress. A
prerequisite is that an applicant has to present
an accepted poster or oral presentation at the
Congress.
FundingAll bursaries are subject to availability of earmarked
sponsorship (no guarantees). The amount of the
bursary will be determined by the judgement of the
Bursary Committee, subject to availability of funds
and merit, and will include at least a sponsored
registration fee.
Application GuidelinesThe application deadline is 31 January 2014.
Applications are submitted online together with
abstract submission on the same web form.
Applications should contain the following:
• The submitted abstract(s) for poster or oral
presentation.
• Short (max. 150 words) motivation for the
bursary application, including a summary
of current research, financial need and how
attending the WCP2014 Congress will benefit
the future academic career.
• The applicant’s abbreviated curriculum vitae,
including an academic record.
• A signed supporting letter, on an official
institutional letterhead, from the applicant’s
supervisor/superior, confirming the applicant’s
current appointment or registration, and
activity in pharmacological research.
IUPHAR Young Investigator AwardsThe purpose of the IUPHAR Young Investigator
Awards is to encourage and recognise excellence
in early career pharmacologists.
Eligibility:The awards are open to pharmacologists who
are no more than 10 years from receipt of their
highest terminal degree (i.e. PhD, MD). The young
investigator must be first author on the submitted
abstract.
How to apply:Candidates who wish to compete for this award
should indicate in the appropriate place on the
electronic abstract form that they wish their
abstract to be considered for an IUPHAR Young
Investigator Award.
Finalists:Ten candidates will be selected by members of
the IUPHAR Executive Committee (Contribution
Judges). Those chosen will be invited to present
their work in a 10-minute oral presentation (plus 5
minutes for questions) in a dedicated symposium
at the World Congress (scheduling to be listed in
the final programme).
After the symposium, judges (selected by members
of the Executive Committee: Presentation Judges)
will select the three recipients of the awards,
based on the candidates’ ability to present their
experimental findings and defend their conclusions
to an international audience.
Awards:Gold Award - $1000 USD
Silver Award - $ 500 USD
Bronze Award - $ 250 USD
The awards will be presented at the closing
Friday 18 July 2014 10:30 – 12:00Track 4 - Epigenetic mechanisms in cell- and drug-
based heart failure therapies
Chair: Lutz Hein
Epigenetic targets and mechanisms in chronic heart
failure - Lutz Hein
Energy metabolism and epigenetic transcriptional
regulation - Andre Terzic
Epigenetic signatures in human induced pluripotent
stem cells - Juan Carlos Izpisua Belmonte
Innovative cell therapeutcs and disease models by
epigenetic reprogramming - Wolfram Zimmermann
Friday 18 July 2014 10:30 – 12:00Track 5 - GRIP: Global training programs in
paediatric pharmacology
Chair: Kalle Hoppu
GRIP (Global research in paediatrics) - Kalle Hoppu
Global curriculum for the fellowship program in
paediatric clinical pharmacology - Shinya Ito
GRIP master’s program in paediatric pharmacology
and clinical trials in children - Evelyne Jacqz Aigrain
GRIP training program for investigators and support
staff for clinical trials in children - John Van Den Anker
GRIP Roadshow and training modules available in
the VLE: Training opportunities for where you are -
Kalle Hoppu
Friday 18 July 2014 10:30 – 12:00Track 6 - Innovative methods for assessing drug
toxicity and efficacy
Chair: Hector Keun
Uncovering the mechanisms of drug toxicity by use
of ~omics technology - Richard Paules
~omics technology in translational drug research -
Andrew Walubo
Predicting drug response from metabolic profiles -
Hector Keun
We hope delegates
enjoy a stimulating
congress.
Continued on page 27...
IUPHAR Gastrointestinal Section Business Meeting
13 July 2014
Cape Town International Conference Centre
Sandor Szabo
Training of Medicines Development and Regulation in Emerging Countries13 July 2014Cape Town International Conference CentreBernd Rosenkranz
PharfA Symposium 1: Regulatory Control of Traditional Medicines
13 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 2: Traditional Medicine Development Strategies
14 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 3: Biological Medicines Development
17 July 2014
Cape Town International Conference Centre
Andrew Walubo
Adrenoceptors: Does Understanding Structure Change Everything? 19 - 23 July 2014 Kruger National Park
BJP - Ian McGrath
Other IUPHAR meetings 8th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection24-26 September, 2014Budapest, HungarySandor Szabo
The World Congress represents a unique opportunity to celebrate and support the two branches of pharmacology, basic and clinical, on an international stage.Jonathan Bruun, Chief Executive Officer, British Pharmacological
The scientific programme looks extremely exciting. I also have a lot of interest in the social programmes, which I am sure will have great African tastes. I look forward to meeting thousands of pharmacologists from all over the world.Masamitsu Iino, Second Vice President, IUPHAR, and SecretaryGeneral, WCP2018 Kyoto Kyotohttp://www.adrenoceptor.com
Society
IATDMCT symposium - Frontiers in
14 July 2014Cape Town International Conference Centrewww.IATDMCT.orgAlexander A Vinks
Therapeutic Drug Management
New Web-based Approaches for Teaching Clinical Pharmacology: Workshop Pscribe14 - 17 July 2014Cape Town International Conference Centrehttp://www.pscribe.euBen Janssen
Congress Satellites (continued)
December 2013
27
ceremony and featured in the post-congress issue of the IUPHAR
newsletter, "Pharmacology International".
Further information about the awards and criteria for partici-pation can be obtained from:
IUPHAR Administrative Office
Lynn LeCount
Administrative Officer
Accompanying Person’s ProgrammeThe Organising Committee has planned an official accompanying
person’s programme. Accompanying persons are required to pay
R1,500 per person, which includes the following:
• Access to the exhibition area for the duration of the Congress
• Attendance at the Official Opening Ceremony
• Attendance at the Welcome Cocktail Party
• Tea and coffee throughout the duration of the Congress
• Formal Congress Identification
In addition, the Organising Committee has compiled an official tours
programme that is sure to appeal to family or friends accompanying
delegates on their trip to South Africa. Participation in these tours is
optional, and the cost of the tours will be added to the fee of R1,500
per accompanying person. The tours will run as follows:
DATE TOURPER PERSON
PRICE
Monday,
14 July 2014
1 – Half Day City Tour
2 – Half Day Township Tour
R495
R605
Tuesday,
15 July 2014
3 – Full Day Cape Peninsula Tour
4 – Half Day Winelands Tour
R935
R655
Wednesday,
16 July 2014
1 – Half Day City Tour
2 – Half Day Township Tour
R495
R605
Thursday,
17 July 2014
3 – Full Day Cape Peninsula Tour
4 – Half Day Winelands Tour
R935
R655
To book, select your preferred option on the registration form.
For assistance, please contact:
Carina du Plessis
Conference Coordinator
Scatterlings Conference & Events
TOUR 1 – HALF DAY CITY TOUR
Half day tour – R495 per person
Depart CTICC at 08h30 and return 13h00.
A comprehensive city tour starting with a short ride to Signal Hill for
a great view of our Cape Town Stadium, Sea Point area and Robben
Island. Other highlights include a brief tour of the Malay Quarter
(Bo-Kaap), city centre, Company Gardens and the Castle of Good
Hope.
TOUR 2 – HALF DAY TOWNSHIP TOUR
Half day tour – R605 per person
Depart CTICC at 08h30 and return 13h00.
Beginning at the District Six Apartheid Museum, the venue is the
the gateway to the understanding of apartheid and the existence
of townships. After this, make your way to Langa, the oldest formal
CTICC = Cape Town International Convention Centre
Continued on page 28...
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township in Cape Town. Here you will visit local projects such as crafters, schools and a crèche.
Stop for refreshments at a local shebeen (tavern - beer optional). Make an appointment with a traditional
healer. This tour offers interaction with local township people - more than half of South Africa’s population
live in townships.
TOUR 3 – FULL DAY CAPE PENINSULA TOUR
Full day tour – R935 per person
Depart CTICC at 08h30 and return 16h00.
Experience some of the most spectacular views in the world. The tour begins with a scenic drive along the
Atlantic coast passing through the fishing village of Hout Bay. Here you will have the option of taking a short
boat trip to Duiker Island to view the Cape Fur seals. The tour then heads along Chapman’s Peak Drive on to
Cape Point and the Cape of Good Hope Nature Reserve. From there we travel to False Bay and return to Cape
Town by way of the Simon’s Town naval base where we visit the penguin colony at Boulders Beach. Travel via
Fish Hoek fishing village and Muizenberg to Kirstenbosch National Botanical Gardens for an optional short
walking tour of these beautiful gardens. Return to Cape Town in the late afternoon.
TOUR 4 – HALF DAY WINELANDS TOUR Half day tour – R655 per person
On this enchanting excursion we travel directly to the quaint town of Stellenbosch, an architectural jewel that
serves as the historic heart of the country’s wine region. We then head for one of the nearby wine estates for a
wine & cheese tasting and cellar tour.
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Nelson Mandela Day
Following the success of Nelson Mandela’s
90th birthday celebrations in London’s Hyde
Park in June 2008, it was decided that there
could be nothing more fitting than to celebrate Mr
Mandela’s birthday each year with a day dedicated to
his life’s work and that of his charitable organisations,
and to ensure his legacy continues forever.
The Mandela Day campaign message is simple:
Mr Mandela gave 67 years of his life fighting for the
rights of humanity. All we are asking is that everyone
gives 67 minutes of their time, whether it’s supporting your chosen charity or serving your local community.
Mandela Day is a call to action for individuals – for people everywhere – to take responsibility for changing the world into a better place, one
small step at a time, just as Mr Mandela did.
WCP2014 ends on Nelson Mandela Day and the Organising Committee is arranging a number of options for delegates to participate in
this important day. The cost per person is R250 and will cover the cost of transport and a small contribution towards the chosen charity /
community work. Please indicate on your registration form if you would like to participate.
Nelson Mandela Day
Following the success of Nelson Mandela’s
90th birthday celebrations in London’s Hyde
Park in June 2008, it was decided that there
could be nothing more fitting than to celebrate Mr
Mandela’s birthday each year with a day dedicated to
his life’s work and that of his charitable organisations,
and to ensure his legacy continues forever.
The Mandela Day campaign message is simple:
Mr Mandela gave 67 years of his life fighting for the
rights of humanity. All we are asking is that everyone
gives 67 minutes of their time, whether it’s supporting your chosen charity or serving your local community.
Mandela Day is a call to action for individuals – for people everywhere – to take responsibility for changing the world into a better place, one
small step at a time, just as Mr Mandela did.
WCP2014 ends on Nelson Mandela Day and the Organising Committee is arranging a number of options for delegates to participate in
this important day. The cost per person is R250 and will cover the cost of transport and a small contribution towards the chosen charity /
community work. Please indicate on your registration form if you would like to participate.
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Registration InformationHow to Register:
Registrations are open – delegates are invited to register by visiting the congress website www.wcp2014.org ,
select “Participate” and then “Register”.
Registration Fees & Entitlements:
CATEGORY
EARLY BIRD
(if registered and paid for by
28 February 2014)
NORMAL
(if registered and paid for
after 28 February 2014)
Standard Registration ZAR 8,000 incl. VAT ZAR 10,000 incl. VAT
Student Registration ZAR 5,000 incl. VAT ZAR 8,000 incl. VAT
Day Delegate ZAR 2,500 incl. VAT ZAR 2,500 incl. VAT
Accompanying Person ZAR 1,500 incl. VAT ZAR 1,500 incl. VAT
Standard Registration includes:• Attendance to all Congress sessions
• Attendance to social event: Welcome Function, Sunday 13 July 2014
• 2 tea / coffee breaks per day
• All published Congress proceedings
• Delegate package
• Access to the Congress exhibition for the day selected
• Gala Dinner tickets are available at an additional cost
• Lunch is not included
Student Registration includes:NB: This option is only open to bona fide FULL TIME students. A letter from your study supervisor/
supervising professor confirming your formal registration as a full time student or a full time appointment
as a postdoctoral fellow, must be included with your registration (a student card is not acceptable).
• Attendance to all Congress sessions
• Attendance to social event: Welcome Function, Sunday 13th July 2014
• 2 tea / coffee breaks per day
• All published Congress proceedings
• Delegate package
• Access to the Congress exhibition for the day selected
• Gala Dinner tickets are available at an additional cost
• Lunch is not included
Continued on page 31...
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Day Delegate Registration – ZAR 2,500 (incl. VAT) per day
• Attendance to all Congress sessions on the day selected
• 2 tea / coffee breaks
• All published Congress proceedings for the day selected
• Delegate package
• Access to the Congress exhibition for the day selected
• Gala Dinner tickets are available at an additional cost
• Lunch is not included
Accompanying Person – ZAR 1,500 (incl. VAT)• Attendance to Opening Function/Welcome Cocktail Function
• 2 tea / coffee breaks in exhibition hall
• Closing ceremony
• Gala Dinner tickets are available at an additional cost
• Access to any Congress sessions not included
Additional Meetings(Delegate must indicate attendance on the registration form, not automatically included in registration fees)
MEETING FEE
Thursday evening, 17 July 2014
Pharmacology for Africa (PharfA) General Assembly No additional cost
Friday afternoon, 18 July 2014
Nelson Mandela International Day excursion ZAR 250 per person
Social EventsWelcome Cocktail – Sunday 13 July 2014 – ZAR 250 (incl. VAT) per person (Included in Full Congress and Day Delegate registration)
• Light cocktail snacks
• Entertainment
• Access to the official opening of the Congress exhibition
• Drinks
Gala Dinner - Wednesday 16 July 2014 – ZAR 990 (incl. VAT) per person (Not included in Full Congress or Day Delegate registration)
• Meal served: set menu
• Entertainment
• A limited drinks selection
* NOTE: All fees are quoted in South African Rand (ZAR).
Congress Bursary GuidelinesObjectiveThe primary goal of the Congress Bursary is to
support young and established pharmacologists
from financially restricted environments and
who are actively involved in research, to attend
and participate in the WCP2014 Congress. A
prerequisite is that an applicant has to present
an accepted poster or oral presentation at the
Congress.
FundingAll bursaries are subject to availability of earmarked
sponsorship (no guarantees). The amount of the
bursary will be determined by the judgement of the
Bursary Committee, subject to availability of funds
and merit, and will include at least a sponsored
registration fee.
Application GuidelinesThe application deadline is 31 January 2014.
Applications are submitted online together with
abstract submission on the same web form.
Applications should contain the following:
• The submitted abstract(s) for poster or oral
presentation.
• Short (max. 150 words) motivation for the
bursary application, including a summary
of current research, financial need and how
attending the WCP2014 Congress will benefit
the future academic career.
• The applicant’s abbreviated curriculum vitae,
including an academic record.
• A signed supporting letter, on an official
institutional letterhead, from the applicant’s
supervisor/superior, confirming the applicant’s
current appointment or registration, and
activity in pharmacological research.
IUPHAR Young Investigator AwardsThe purpose of the IUPHAR Young Investigator
Awards is to encourage and recognise excellence
in early career pharmacologists.
Eligibility:The awards are open to pharmacologists who
are no more than 10 years from receipt of their
highest terminal degree (i.e. PhD, MD). The young
investigator must be first author on the submitted
abstract.
How to apply:Candidates who wish to compete for this award
should indicate in the appropriate place on the
electronic abstract form that they wish their
abstract to be considered for an IUPHAR Young
Investigator Award.
Finalists:Ten candidates will be selected by members of
the IUPHAR Executive Committee (Contribution
Judges). Those chosen will be invited to present
their work in a 10-minute oral presentation (plus 5
minutes for questions) in a dedicated symposium
at the World Congress (scheduling to be listed in
the final programme).
After the symposium, judges (selected by members
of the Executive Committee: Presentation Judges)
will select the three recipients of the awards,
based on the candidates’ ability to present their
experimental findings and defend their conclusions
to an international audience.
Awards:Gold Award - $1000 USD
Silver Award - $ 500 USD
Bronze Award - $ 250 USD
The awards will be presented at the closing
IUPHAR Gastrointestinal Section Business Meeting
13 July 2014
Cape Town International Conference Centre
Sandor Szabo
Training of Medicines Development and Regulation in Emerging Countries13 July 2014Cape Town International Conference CentreBernd Rosenkranz
PharfA Symposium 1: Regulatory Control of Traditional Medicines
13 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 2: Traditional Medicine Development Strategies
14 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 3: Biological Medicines Development
17 July 2014
Cape Town International Conference Centre
Andrew Walubo
Adrenoceptors: Does Understanding Structure Change Everything? 19 - 23 July 2014 Kruger National Park
BJP - Ian McGrath
Other IUPHAR meetings 8th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection24-26 September, 2014Budapest, HungarySandor Szabo
The World Congress represents a unique opportunity to celebrate and support the two branches of pharmacology, basic and clinical, on an international stage.Jonathan Bruun, Chief Executive Officer, British Pharmacological
The scientific programme looks extremely exciting. I also have a lot of interest in the social programmes, which I am sure will have great African tastes. I look forward to meeting thousands of pharmacologists from all over the world.Masamitsu Iino, Second Vice President, IUPHAR, and SecretaryGeneral, WCP2018 Kyoto Kyotohttp://www.adrenoceptor.com
Society
IATDMCT symposium - Frontiers in
14 July 2014Cape Town International Conference Centrewww.IATDMCT.orgAlexander A Vinks
Therapeutic Drug Management
New Web-based Approaches for Teaching Clinical Pharmacology: Workshop Pscribe14 - 17 July 2014Cape Town International Conference Centrehttp://www.pscribe.euBen Janssen
Congress Satellites (continued)
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Congress Satellites
11th International Society for Serotonin Research Meeting - WCP2014 Satellite
09 - 11 July 2014
Arabella, Hermanus
www.serotoninclub.orgSheryl Beck
Integrative and Organ Systems Pharmacology (IOSP) training workshop. This workshop covers in vivo experimental pharmacology for young scientists.
07 - 11 July 2014
University of KwaZulu Natal, Durban
Emerging Trends in the Pharmacology of Drugs for Hypertension and Heart Failure with a Special Focus on the RAAS
10 - 12 July 2014
Spier Conference Centre
Edward Sturrock
International Symposium on Methods for Studying Drug Metabolism and Transport, and Herbal Derived Medicines
10 - 11 July 2014
Lord Charles Hotel, Somerset West, Cape Town
www.methods2014.orgAndrew Walubo
IUPHAR Education Section Satellite Meeting 12 - 13 July 2014
Cape Town International Conference Centre
www.iuphar-ed2014.orgSimon Maxwell/Zelda Coetzee
Basic & Clinical Neuroscience Symposium Southern African NeuroscienceSociety (SANS)13 July 2014University of Cape TownFleur Howells
Novartis Institutes of BioMedical Research (NIBR) Drug Discovery andDevelopment Workshop12 - 13 July 2014Cape Town International Conference CentreRoss TraceyTitle: Clinical Pharmacology Workshop
This significant conference will not only deliberate on advances in the field and solutions to current challenges, but also increase awareness of the importance of pharmacology research both in South Africa and our continent.Albert van Jaarsveld, Chief Executive Officer, National Research Foundation, South Africa
It is gratifying that the country’s achievements in the treatment and prevention of diseases such as poliomyelitis, epidemic meningitis, tuberculosis, malaria, human papillomavirus infection, HIV infection and numerous other infections and diseases have been recognized and appreciated. The fact that the 2014 IUPHAR meeting is being held in the country is indication of such recognition and will assuredly give impetus for more.Peter Folb, Past President, South African Society of Basic & Clinical Pharmacology
As founder member and past president of the South African Society for Basic and Clinical Pharmacology, it gives me great pleasure to anticipate and, hopefully, to experience in person, the impact that this historic congress is bound to have on tuition, training, and research in the fields of basic and clinical pharmacology in Africa, and, indeed, the whole world, to prevent and treat disease.Frank Otto Muller, Past President, South African Society of Basic & Clinical Pharmacology
This meeting offers a tremendous opportunity for scientists across the globe to network and share the latest developments. WCP2014 also provides a venue for young scientists to interact with scientific leaders in basic and clinical pharmacology.Judith A. Siuciak, Executive Officer, ASPET
Continued on page 33...
See page 79 for details!
See page 78 for details!
See page 76 for details!
See page 74 for details!
December 2013
33
IUPHAR Gastrointestinal Section Business Meeting
13 July 2014
Cape Town International Conference Centre
Sandor Szabo
Training of Medicines Development and Regulation in Emerging Countries13 July 2014Cape Town International Conference CentreBernd Rosenkranz
PharfA Symposium 1: Regulatory Control of Traditional Medicines
13 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 2: Traditional Medicine Development Strategies
14 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 3: Biological Medicines Development
17 July 2014
Cape Town International Conference Centre
Andrew Walubo
Adrenoceptors: Does Understanding Structure Change Everything? 19 - 23 July 2014 Kruger National Park
BJP - Ian McGrath
Other IUPHAR meetings 8th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection24-26 September, 2014Budapest, HungarySandor Szabo
The World Congress represents a unique opportunity to celebrate and support the two branches of pharmacology, basic and clinical, on an international stage.Jonathan Bruun, Chief Executive Officer, British Pharmacological
The scientific programme looks extremely exciting. I also have a lot of interest in the social programmes, which I am sure will have great African tastes. I look forward to meeting thousands of pharmacologists from all over the world.Masamitsu Iino, Second Vice President, IUPHAR, and SecretaryGeneral, WCP2018 Kyoto Kyotohttp://www.adrenoceptor.com
Society
IATDMCT symposium - Frontiers in
14 July 2014Cape Town International Conference Centrewww.IATDMCT.orgAlexander A Vinks
Therapeutic Drug Management
New Web-based Approaches for Teaching Clinical Pharmacology: Workshop Pscribe14 - 17 July 2014Cape Town International Conference Centrehttp://www.pscribe.euBen Janssen
Congress Satellites (continued)
Is Your Organization Interested in Hosting a Satellite
Meeting/Social Event/Symposia?For more information visit
www.WCP2014.org/index.php/participate/satellite
IUPHAR Gastrointestinal Section Business Meeting
13 July 2014
Cape Town International Conference Centre
Sandor Szabo
Training of Medicines Development and Regulation in Emerging Countries13 July 2014Cape Town International Conference CentreBernd Rosenkranz
PharfA Symposium 1: Regulatory Control of Traditional Medicines
13 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 2: Traditional Medicine Development Strategies
14 July 2014
Cape Town International Conference Centre
Andrew Walubo
PharfA Symposium 3: Biological Medicines Development
17 July 2014
Cape Town International Conference Centre
Andrew Walubo
Adrenoceptors: Does Understanding Structure Change Everything? 19 - 23 July 2014 Kruger National Park
BJP - Ian McGrath
Other IUPHAR meetings 8th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection24-26 September, 2014Budapest, HungarySandor Szabo
The World Congress represents a unique opportunity to celebrate and support the two branches of pharmacology, basic and clinical, on an international stage.Jonathan Bruun, Chief Executive Officer, British Pharmacological
The scientific programme looks extremely exciting. I also have a lot of interest in the social programmes, which I am sure will have great African tastes. I look forward to meeting thousands of pharmacologists from all over the world.Masamitsu Iino, Second Vice President, IUPHAR, and SecretaryGeneral, WCP2018 Kyoto Kyotohttp://www.adrenoceptor.com
Society
IATDMCT symposium - Frontiers in
14 July 2014Cape Town International Conference Centrewww.IATDMCT.orgAlexander A Vinks
Therapeutic Drug Management
New Web-based Approaches for Teaching Clinical Pharmacology: Workshop Pscribe14 - 17 July 2014Cape Town International Conference Centrehttp://www.pscribe.euBen Janssen
Congress Satellites (continued)
See page 81 for details!
See page 54 for background!
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The Organising Committee has compiled a pre- and post-congress tour programme for delegates
and accompanying persons to experience the rest of South Africa and surrounding countries. The
following tours are planned:
DESCRIPTION SINGLEDOUBLE
(per person sharing)
Kruger National Park (3 days / 2 nights) R9,705 R8,350 per person
Garden Route (4 days / 3 nights) R10,455 R9,280 per person
Victoria Falls Fly In (3 days / 2 nights) R14,410 R10,690 per person
Blue Train Classic (2 days / 1 night) TBA TBA
Kruger Park Walk in the Wild Safari (4 days / 3 nights) R11,685 R9,100 per person
Zambia Victoria Falls & Chobe Fly In Safari (5 Days /
4 Nights)R27,835 R21,595 per person
Sun City and Pilanesberg Nature Reserve Tour (Full
Day Tour, Johannesburg based)R2,335 per person –
Kruger National Park3 Days / 2 Nights
Single: R9,705
Double: R8,350 per person sharing
Experience the unforgettable sights and sounds of Africa’s wilderness
See more of what the Kruger surrounds have
to offer by travelling in a luxury coach from
Johannesburg to the scenic town of Hazyview
situated on the border of South Africa’s greatest
safari destination, the Kruger National Park. You will
enjoy game drives in a closed vehicle with viewings
at waterholes, rest breaks at camps and tranquil
overnight stays at a picturesque safari hotel.
Blue Train Classic2 Days / 1 Night
2014 pricing not available yet
All the grace, elegance and ro-mance of a 5-Star luxury train journey
The Blue Train is synonymous with the finest,
most gracious travel, evoking all the refinement
and luxury of the Victorian era. This two day
journey from Cape Town to Pretoria traverses
the scenic Cape Winelands and the stunning
dry plains and mountains of the Klein and
Groot Karoo to reach the grasslands of the
Highveld. While the immense scenery of South
Africa passes by, you will enjoy relaxing in your
opulent suite or the elegant lounges, as well as
dining in Silver Service tradition featuring the
best of local cuisine and award-winning wines.
Pre & Post Congress Tours
Continued on page 35...
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Zambia Victoria Falls & Chobe Fly In Safari5 Days / 4 Nights
Single: R27,835
Double: R21,595 per person sharing
Your ultimate African adventureExperience an Africa-of-old on this five day guided journey to one of
the Seven Natural Wonders of the World, Victoria Falls, where you
still feel the same sense of wonderment the early explorers did
more than a century ago. It is a short road trip over the border into
Botswana where you’ll go on safari in the unspoiled Chobe National
Park and revel in the magnificent wilderness of this continent.
Garden Route4 Days / 3 Nights
Single: R10,455
Double: R9,280 per person sharing
Explore the Garden Route and its abundant attractions in just four days
Experience the highlights of the Garden Route, travelling from Port
Elizabeth to Cape Town in this short four day tour. Visit Tsitsikamma
National Park en route to the quaint holiday town of Knysna. Enjoy
the bright greens and blues of the forests and lagoons and the
evocative landscapes of the Klein Karoo and Oudtshoorn.
Kruger Park Walk in the Wild Safari4 Days / 3 Nights
Single: R11,685
Double: R9,100 per person sharing
Take a walk on the wild side in AfricaIn the golden morning light, set out on foot along rhino tracks and
elephant paths to enjoy superb close encounters with Big 5 game
and many other animals and birds in the Africa wilderness. This is an
authentic safari adventure that evokes all the romanticism, excitement
and awe of the century-old explorer days. Your professional armed
rangers will ensure your safety and every comfort while you make
the memories that last a lifetime.
Victoria Falls Fly In3 Days / 2 Nights
Single: R14,410
Double: R10,690 per person sharing
Experience one of the Seven Wonders of the Natural World
Stand in the footsteps of David Livingstone on Livingstone Island,
the only accessible land in the middle of the Victoria Falls. Feel the
spray on your face, hear the roar in your ears as you experience the
same awe and wonder at the extraordinary spectacle of the Victoria
Falls.
Space is limited - book early!
www.WCP2014.org/index.php/travel-info/tours
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Sun City & Pilanesberg Nature Reserve TourFull Day Tour (Johannesburg based)
R2,335 per person
Combine local shopping with Big 5 fun and a dose of glitz and glamour Travel through the Crocodile Ramble and visit the popular Chameleon Village near Hartbeespoort Dam,
boasting various African arts and crafts, en route to Sun City and the Pilanesberg National Park. Sun
City is not only a luxury casino and resort but is also a flagship structure associated with times during the
Apartheid South Africa. Bordering this entertainment complex, you will find one of the world’s outstanding
geological phenomena; a crater of a long extinct volcano and the result of eruptions some 1,200 million
years ago – The Pilanesberg Game Reserve. This area of 572 square km is now home to most southern
African species including lion, elephant, buffalo, rhino and leopard. Enjoy a closed vehicle game drive,
seeking out the Big Five, followed by a guided tour of the famous Sun City Resort including the Valley of
the Waves and Waterworld (entrance fee not included).
The West African Society for Pharmacology (WASP/SOAP) is really excited at the prospect of WCP2014; and that the IUPHAR World Congress is taking place in Africa for the first time. Members plan to participate in large numbers, and present the quality pharmacological research they carried out (despite several constraints) especially in the areas of natural products, isolated tissue and whole animal models. We look forward to forging research networks and collaborations with other pharmacologists from around the world.Helen O. Kwanashie, President, West African Society for
Hosting the WCP on the African continent should serve as a boost for all the pharmacologists in the developing countries, particularly those in Sub-Saharan Africa to come together and put a common front to face the challenges ahead of us.Claude Kirimuhuzya, Secretary General, Uganda Pharmacological Society
Pharmacology (WASP) / Societe Quest Africaine de
Pharmacologie (SOAP)
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Thank you to our sponsors
National Research Foundation North-West University
British Pharmacological Society
Department of Science and Technology South Africa
Medical Research Council of South Africa
American Society for Pharmacology & Experimental Therapeutics
The International Union of Basic and Clinical Pharmacology
Janssen
Pharmaceutical Industry Association of South Africa
Diamond Sponsor Platinum Sponsor
Gold Sponsor Silver Sponsor
Bronze Sponsor
Blue Sponsor Other Sponsor
Boehringer Ingelheim
Hong Kong Pharmacology Society
Novartis
Les Laboratoires Servier
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WCP2014 Offerings: A Review by the IUPHAR
Clinical Pharmacology DivisionThe organizers of WCP2014 have developed a wonderful program fulfilling the promise of a satisfying melding of basic and clinical pharmacology. Nearly all, if not all, sessions have clinical pharmacology content and the basic pharmacology is always linked with a therapeutic context - a great way for clinicians to catch up on the advances in the basic pharmacology of their area of interest. Following is an overview of some of the clinical pharmacology content in the program but we strongly advise all interested to have a look at the detailed program at http://www.wcp2014.org/index.php/programme/scientific-programme.
The IUPHAR Division of Clinical Pharmacology Council will meet on Monday 14 July 2014 at 5:00 – 7:00 p.m. in meeting room 1.72. Members of the current council are at http://www.iuphar.org/clin_officers.html.
The General Assembly of the Clinical Division will be held on Thursday 17 July at 5:00 – 7:00 p.m. in meeting room 1.4. All interested in clinical pharmacology are invited and encouraged to attend. The election of officers and councillors for the next four years will be held during the General Assembly.
Every day of the congress has clinically related plenary lectures. On Monday Simon Maxwell addresses training tomorrow’s prescribers. Then Tuesday Brian Strom talks on pharmacoepidemiology. For Wednesday Suzanne Hill and Clive Ondari address medicine selection in high income countries and emerging economies, respectively. Thursday brings Munir Pirmohamed to speak on drug safety science. On Friday we have Nicholas Holford on pharmacometrics, Dan Roden on pharmacogenomics and Nicholas White on antimalarial medicines.
The Clinical Pharmacology Division is sponsoring four symposia during the meeting:
Update in geriatric pharmacology - Optimal prescribing in older patients: The challenge of multiple comorbid conditions and polypharmacy (Chair: Darrell Abernethy)Multiple comorbid conditions and disease-based treatment guidelines: The
therapeutic dilemma for older persons with geriatric syndromes by Sarah HilmerMethods to assess drug burden and polypharmacy by Petra ThürmannDeprescribing to limit polypharmacy: The evidence base by David LeCouteurEffects of new drugs in older patients: What is known at the time of drug approval?
by Darrell Abernethy
Hot topics in pharmacoeconomics (Chair: Suzanne Hill)Pharmaceutical pricing: What are the current policy approaches for managing prices?
by Alexandra CameronA tale of two molecules: Marketing and legal influences on cost by Nicola MagriniCompulsory licensing and HTA by Sripen TantivessHigh cost challenges: Paying for targeted therapies by Suzanne Hill
Continued on page 39...
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Pharmaco-epidemiology: at the cutting edge (Chair: Brian Strom)Using big data in comparative effectiveness research by David HenryStreamline randomised comparative effectiveness by Thomas MacDonaldComparative effectiveness research using a national health insurance database in Taiwan by Kin-Wei Arnold ChanUse of a large simple trial design for comparative effectiveness research: The Ziprasidone Observational Study of
Cardiac Outcomes (ZODIAC) by Brian Strom
Controversies in essential medicines (Chair: Clive Ondari)Selecting medicines for off-label indications: A global perspective by Andy GraySelecting essential medicines for cancer: The EMLc approach by Clive OndariManaging essential medicines in rare/neglected diseases by Elizabeth Mathai
Besides these sponsored sessions, there are three sessions dedicated to paediatric clinical pharmacology including one on the GRIP program, a global training program in paediatric pharmacology. There are a number of symposia on drug discovery, development and regulation in relation to both conventional medicines and herbal and natural products. Teaching pharmacology and clinical pharmacology is extensively covered in a number of sessions, as are regulatory issues and medicines policy. Modelling, simulation and pharmacometrics are included at the macro and micro levels. As expected, there is a comprehensive track on infectious diseases with HIV, malaria, TB and vaccines prominent. Neurological, metabolic and inflammatory/immune diseases each have solid symposium tracks and there is good clinical content in all.
A list of some of the disease or therapy specific symposia follows:Pharmacology of novel tuberculosis regimensNovel therapeutic strategies in HIVNew drugs for neglected infectious diseasesRecent breakthroughs in malaria treatmentImmunobiologicals and chronic inflammatory diseasesGlobal HIV clinical pharmacology capacity building and implementation researchRethinking mood therapeutics: Novel pharmacological approaches for anxiety and depressionCombination medications as novel treatments for stimulant addictionAdvances in reproductive pharmacologyAspirin, the wonder drugAdvances in GI pharmacology: New approaches to upper and lower GI ulcers and inflammationNew challenges for the treatment of diabetes mellitusProblems with OTC analgesicsTherapeutic monoclonal antibodies in oncologyTargeted small molecule therapy in oncologyTargeting B cell signalling in oncology
There are also pre-congress satellites and workshops which can be accessed on the congress website.
Altogether it is an enticing program for clinical pharmacologists. The organizers are to be congratulated.
See you there! •
Don BirkettChair, IUPHAR Division of Clinical Pharmacology
WCP2014 Offerings in Clinical Pharmacology
(continued)
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WCP2014 Contributions from NC-IUPHAR Members
NC-IUPHAR is well represented at WCP2014 with six members giving plenary lectures or organising symposia. Put the below sessions in your itinerary for a great scientific experience linked to the unique experience of visiting South Africa!
IUPHAR Analytical Pharmacology Lecture
Adventures in allostery: From function to structureArthur Christopoulos (see page 10)
Plenary Speakers
Tyrosine kinase inhibitors Doriano Fabbro (see page 11)
Protein phosphorylation in signal transduction Kozo Kaibuchi (see page 11)
Amino acid transporters in oncology Yoshikatsu Kanai (see page 12)
Challenges in training tomorrow’s prescribers Simon Maxwell (see page 13)
Signal transduction in therapeutics Richard R. Neubig (see page 13)
Symposia
Monday, 14 July 2014, 13:30 – 15:00, Track 6 (see page 17)Orphan G protein-coupled receptors: What are the new ligands & drug targets?Chair: Anthony DavenportGPCRs are targets for nearly half of all medicines and represent a significant proportion of the ‘druggable’ genome as these proteins have proved remarkably tractable to medicinal chemistry strategies to discovery new therapeutic agents. NC-IUPHAR presents the evolving pharmacology of ‘orphan’ GPCRs recently paired with their cognate ligands and stimulating progress in ‘de-orphanising’ the remaining GPCRs predicted to exist from the human genome.
Orphan GPCRs: What are the remaining “druggable” targets? Adam Pawson
Therapeutic potential of biased apelin agonists and antagonists Anthony Davenport
From AIDS to atherosclerosis: Chemokines, CCR5 and maraviroc Janet Maguire
Role of cannabinoid-related receptors (GPR55, GPR18 and GPR119) in inflammation, satiety and obesityStephen Alexander
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Tuesday, 15 July 2014, 13:30 – 15:00, Track 7 (see page 20)Structural basis for ion channel pharmacologyChair: William A. CatterallAdvances in the structural biology of complex intrinsic membrane proteins have allowed determination of the structures of key ion channels and ionotropic neurotransmitter receptors at high resolution by x-ray crystallography. This Symposium will focus on the structural basis for the function and pharmacology of four different families of ion channels and receptors.
Structural basis for drug action on the cys-loop family of receptorsPierre-Jean Corringer
Outer structures in ionotropic glutamate receptors as drug targetsLonnie P. Wollmuth
Structural basis for function and pharmacology of voltage-gated sodium and calcium channels William A. Catterall
Tuesday 15 July 2014 15:30 – 17:00, Track 6 (see page 20)NC-IUPHAR and the Guide to PharmacologyChairs: Michael Spedding and Colin DolleryThe immense recent growth of knowledge about drug targets, with their crystal structures, has been an immense help to drug discovery. The IUPHAR classifications have been of great use, together with the database, in defining nearly all potentially “druggable” sites encoded by the human genome. The IUPHAR open access, online database provides detailed, expert-driven annotation of the primary literature on human and rodent receptors and other drug targets, together with the substances that act on them. Information on the products of >646 genes from four major protein classes (G protein-coupled receptors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and over 3,000 bioactive molecules that interact with them. The clinical relevance of targets and ligands in the database, more extensive links to other databases and curation of enzymes as drug targets are all underway to have a freely-accessible Guide to Pharmacology. A new teaching initiative for pharmacology is created by collaboration between IUPHAR, BPS and ASPET in the form of a website, based at Edinburgh. The presentation will describe the approach, and time lines of a major new initiative for clinical and preclinical pharmacology education worldwide, in synergy with the NC-IUPHAR, IUPHAR-DB and GuideToPharmacology.org.
Brief Introduction to NC-IUPHAR Colin Dollery
NC-IUPHAR: How two decades of controversy help resolve drug discovery Michael Spedding
IUPHAR-DB, GRAC and the Guide to Pharmacology Adam Pawson
The IUPHAR educational website Simon Maxwell
WCP2014 Contributions from NC-IUPHAR Members
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Wednesday, 16 July 2014, 10:30 – 12:00, Track 6 (see page 21)Evolution, sport and modern diseasesChairs: Michael Spedding and Ian McGrathThe ”two stage evolution” hypothesis of the evolution to run, from ~100,000 years ago, adapted to all the earth’s environmental niches, (the latter using predominantly epigenetic and diet-driven bioflora changes, with contributions from SNPs/CNVs), explains much of susceptibility to many modern diseases. The brain circuits crucial to persistence hunting and associated social interactions control context and emotion, and are the weak link in psychiatric disorders. Furthermore, these circuits represent the long-searched-for central regulator limiting ultimate sports performance. The biochemical drivers of ‘evolutionary-recent’ change in nerve and muscle are partially defined and point to dysfunction in the trophic/inflammatory interface in disease processes.
Evolution and running Tim Noakes
Do sports reveal the end of a long range physiological evolution? Jean-François Toussaint
Aging and exercise: Mechanisms and benefit in offsetting disease Paul Greenhaff
Brain development and evolution: Mechanisms, circuits, and susceptibility to disease Michael Spedding
Wednesday, 16 July 2014, 15:30 – 17:00, Track 6 (see page 23)Emerging drug targetsChair: Richard NeubigA range of new drug targets will be described. which are at the cutting edge for innovative therapies
Plucking the high hanging fruit: Synthetic strategies for targeting protein-protein interactions in transcriptionParamjit Arora
Allosteric targeting of protein-protein interactions: RGS proteins in CNS therapeutics Richard Neubig
Anti-apoptosis therapies in cancer Simone Fulda
WCP2014 Contributions from NC-IUPHAR Members
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Thursday, 17 July 2014, 13:30 – 15:00, Track 4 (see page 24)Can academic drug discovery deliver in rare diseases?Chair: Michael SpeddingSelected institutions have tackled the challenges associated with drug discovery for rare diseases. The efforts and techniques of four groups are featured.
The Monash Institute of Pharmaceutical Sciences (MIPS): Integrating discovery, delivery and development Bill Charman
Association Française contre les Myopathies: A 25 year revolution in rare diseasesSerge Braun
Structural Genomics Consortium as a springboard for discovery in epigenetics and kinasesChas Bountra
Dundee Drug Discovery Unit: Diversity screening for tropical diseases David Gray
Be sure to add this great line-up to your WCP2014 itineray. •
Michael SpeddingChair, NC-IUPHAR
WCP2014 Contributions from NC-IUPHAR Members
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In MemoryWilliam C. Bowman
April 26, 1930 - July 18, 2013
Reproduced with permission from the British Pharmacological Society
The British Pharmacological Society lost one of its luminaries on Thursday, 18 July, with the death of Bill Bowman. Bill’s health had deteriorated since a stroke in London a couple of years ago. After a very lengthy stay in hospitals in London and Dumfries, he managed to get home to Rockcliffe on the Solway Firth, which held so many happy memories for him. His daughter, Alison, and son, Ewen, told us that over the past few months, and particularly the last few weeks, he became bedbound and life became incredibly tough. He died very peacefully; it was the most glorious evening in Rockcliffe, still and hot with the sun setting over Rough Island, just as he would have wished.
Bill started his academic career through obtaining a first class honours degree in pharmacy from the London School of Pharmacy (“The Square”), which is now, of course, part of University College London. During this time, he was inspired by Eleanor Zaimis who invited him to join her group to work for a PhD, in which he studied the effects of sympathomimetic amines on the contractility of skeletal muscle. He demonstrated, for the first time, that adrenaline, while enhancing the contractility of fast contracting muscle, actually reduced twitch tension in slow contracting muscle, this ultimately being identified as the possible basis of the tremorigenic action of β2-receptor agonists.
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The time between submitting his PhD thesis and actually being examined was interrupted by the Ministry of Defence, who suddenly required his assistance in defending the realm through two years of National Service. He found himself in the Royal Air Force (RAF), which provided the basis of numerous, some unrepeatable, anecdotes with which he used to regale us many years later over the odd pint or two in the pub. He told us that because of his background, the RAF decided he should become an Education Officer and packed him off on a teacher training course, following which he was required to teach aerodynamics! During his National Service he was allowed to attend his PhD examination in Oxford, which he attended in full RAF uniform with Edith Bülbring as external examiner.
When Her Majesty’s forces felt sufficiently safe to dispense with his services, he joined the Square as a lecturer under the mentorship of Gladwyn Buttle. His time at the School of Pharmacy was very productive; the pharmacology department at the Square was a pharmacological powerhouse including staff members such as Geoff West, Alan Cuthbert, Brian Callingham, Tom Bolton, Colin Raper and Mike Rand. Among Bill’s other scientific contributions during that period was the development of the concept of pre-junctional nicotinic autoreceptors (Blaber and Bowman 1963), which was pursued later at Strathclyde in collaboration with Ian Marshall (Bowman 1989). While at the Square, Bill, Mike Rand and Geoff West decided to fill a gap by writing a textbook aimed primarily at pharmacy students. This progressed to a second edition in 1980 with only Mike as co-author and became the standard textbook of pharmacology worldwide, translated into many languages. It was generally referred to as “Bowman and Rand” except in Portugal where, to Bill’s mischievous delight, its author(s) was (were) described as “Rand Y Bowman”! Sadly, although well-advanced in preparation, the third edition never materialised, due to a fire in 1990 that destroyed Mike Rand’s house along with extensive drafts of the book, and then Mike’s death in 2002, after which Bill lost the will to work further on this enormous task, which he and Mike had been determined to complete without farming out chapters to numerous colleagues.
Buttle’s retirement in 1965 resulted in a Square pharmacological diaspora and Bill’s move to establish the Department of Pharmacology at the new University of Strathclyde in 1966, an event that was to place Strathclyde firmly on the world’s pharmacological map. Bill’s presence at Strathclyde attracted people to join the department as staff members, notably Jim Parratt, whom he invited to take up an appointment in 1967, following which the department grew rapidly.
At Strathclyde, Bill revisited his earlier work on the effects of sympathomimetics on skeletal muscle with Mike Nott and Ian Rodger (e.g. Bowman and Nott 1970), as well as developing a lasting interest in neuromuscular blocking drugs, this being stimulated by the close proximity of Organon laboratories, which at the time of Bill’s arrival was developing pancuronium. The fruitful collaboration with Ian Marshall in the department and Organon led to the identification, development and subsequent marketing of vecuronium and rocuronium, two of the most extensively used muscle
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William C. Bowman(continued)
relaxants in anaesthetic practice. This resulted in Bill’s wide recognition among anaesthetists and his being made an honorary fellow of the Faculty of Anaesthetists of the Royal College of Surgeons, of which he was especially proud, and his appointment as visiting professor of anaesthesiology in various universities in Canada and the US. His other interests at the neuromuscular junction in collaboration with Ian Marshall and Alan Harvey focused on the aminopyridines as reversal agents for neuromuscular blockade and their potential application in conditions of impaired neuroeffector transmission (Bowman and Savage 1981).
Bill’s long friendship and collaboration with Mike Rand and Mike’s return to Australia in 1965, resulted in so many Australian visitors and PhD students in the department, that Bill’s research laboratory became known as ‘Kangaroo Valley’ and was formally labelled as such! This was in the days before ‘health and safety at work’ and the department was then on the roof of Strathclyde’s Royal College building. My recent attempt at a sentimental revisit to the old laboratories (abandoned many years ago) to see if the label remained was thwarted by the fact that access to the roof laboratories had been well and truly sealed off, presumably to stop pharmacologists jumping from the roof after a failed grant application. One frequent Australian visitor to the department, and one cause of Bill’s trips to Melbourne (the excuse being the textbook!) was the delightful Anne Stafford, a distinguished pharmacologist, whom he married in the early 1970s. Sadly, Anne died in 2007 after a long illness. As happens frequently with senior academics, Bill moved into senior positions in the University, becoming successively Deputy Principal (Pro-Vice Chancellor in English parlance) and Vice-Principal, thus progressively removing him from active involvement in pharmacology research. I was never certain how much Bill enjoyed the trappings of high office, but his friend and colleague Dr. Peter West, who was University Secretary at that time, tells me that Bill described his role as “drinking gin and tonic on behalf of the University”! Despite this laid back approach, he went on to be an outstanding Vice Principal, playing a key role in steering the University through difficult times. Throughout his time away from the department, he retained close contact with the world of pharmacology through his extensive involvement with the British Pharmacological Society, in which he held a number
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William C. Bowman(continued)
Bill enjoyed a reunion of his colleagues and friends during September, 2012.L → R: Karen Furman, Bill Bowman, Bill Dryden, Kathy Kane, Moira Hall-Wadsworth, Brian Furman and Roger Wadsworth
of executive posts, and IUPHAR, which he served as Secretary-General from 1994-1998, becoming the first Editor-in-Chief of Pharmacology International. The British Pharmacological Society recognized his contribution to the Society and to the discipline of pharmacology through electing him as an Honorary Fellow and through establishing the Bill Bowman Travelling Lectureship, awarded annually to support the development of a young pharmacologist, a matter that was always close to Bill’s heart. On his retirement, the University perpetuated his name by establishing the WC Bowman Chair of Pharmacology.
We have lost an inspirational teacher, a brilliant lecturer, a walking encyclopaedia of pharmacology and a mentor to numerous pharmacologists around the globe. Our thoughts are with his children, Alison and Ewen, and grandchildren, Cammie, Ewan, Emma and Keith. •
Brian Furman (On behalf of Bill’s numerous friends and colleagues at the University of Strathclyde)
ReferencesBlaber LC, Bowman WC. Studies on the repetitive discharges evoked in motor nerve
and skeletal muscle after injection of anticholinesterase drugs. Br J Pharmacol Chemother. 1963; 20:326-344
Bowman WC. Presynaptic nicotinic autoreceptors. Trends Pharmacol Sci. 1989; 10:136-137
Bowman WC, Nott MW. Actions of some sympathomimetic bronchodilator and beta-adrenoceptor blocking drugs on contractions of the cat soleus muscle. Br J Pharmacol. 1970; 38:37-49.
Bowman WC, Savage AO. Pharmacological actions of aminopyridines and related compounds. Rev Pure Appl Pharmacol Sci. 1981; 2:317-71
Bowman WC, Zaimis E. The effects of adrenaline, noradrenaline and isoprenaline on skeletal muscle contractions in the cat. J Physiol. 1958; 144: 92-107
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Professor emeritus Folke Sjöqvist turned 80 years old in May, 2013. The event was celebrated with a symposium on May 24th at Karolinska Institute in Stockholm, which was organized by Professors Gunnar Alván, Marja-Liisa Dahl (co-chair), Rune Dahlqvist, Erik Eliasson, Lars L. Gustafsson, and Georgios Panagiotidis (co-chair) on behalf of the Clinical Pharmacology Department at Karolinska Institute/Karolinska University Hosptial Stockholm. The symposium was supported by the Foundation for Clinical Pharmacology and Therapeutics, Stockholm.
The topics covered highlighted Professor Sjöqvist’s contributions and achievements in health care, teaching and research: Rational Use of Medicines, Personalised Medicine and Diagnostics and Global Medicine. In addition, there were presentations on describing current clinical pharmacology research programs in Sweden. The 140 participants included collaborators, colleagues, friends and family traveling to Stockholm from three continents and 14 countries.
The opening presentation was given by Professor Rune Dahlqvist, Editor of European Journal of Clinical Pharmacology. Professor Dahlqvist also presented Professor Sjöqvist a copy of the supplementary issue of the journal (cover at right) that was prepared as a tribute to him [1].
Rational Use of Medicines
Professor Sir Michael Rawlins, former chairman of the National Institute for Health and Care Excellence (NICE) in the United Kingdom presented
Symposium in Honor of Professor Folke Sjöqvist
Clinical Pharmacology in Health Care, Teaching and Research: The Future
Editor’s Note: IUPHAR has had the good fortune of Professor Sjöqvist leading the IUPHAR Clinical Division as a past president in addition to his more recent
contributions as an IUPHAR liaison to the World Health Organization. We thank his colleagues at Karolinska for sharing this article.
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a talk entitled The societal challenge of making important drugs available to patients. Professor Rawlins emphasized that only in Europe do the expenses for health and healthcare vary 10-fold across countries, with the size of the expenditure correlating with GNP. He noted that most healthcare institutions are challenged in identifying ways to pay for newer, more expensive medications. The NICE and other health technology assessment institutions are forced to make decisions about availability and payments without, in many cases, the benefit of data from studies designed to directly compare a new drug with an older agent (head-to-head trials). While prioritization is typically based on the “incremental cost-effectiveness ratio”, NICE also considers the views from a council of laymen when making this decision. Rawlins emphasized the need for a global, value-based pricing scheme for medications, and noted this approach has already been implemented by some countries.
Professor Lars L. Gustafsson, from Karolinska Institute, spoke on behalf of Associate Professor Richard Malmström on Critical unbiased drug evaluation - a cornerstone of introduction of new drugs in Stockholm Healthcare Region. He reported that the purchase of new, specialized medicines accounts for over 50% of medication expenditures in Stockholm and elsewhere. He suggests that what is needed is a new model for introducing medicines. Professor Gustafsson described successful Stockholm approaches to addresses this issue, including horizon scanning, health economic evaluations, and follow-up studies. The new oral anticoagulants, including dabigatran, provide proof of concept for these strategies [2]. The present method for selection and recommendation of essential drugs in the Stockholm “Wise List” will be complemented by “Wise Protocols”, which will cover the introduction of new, expensive medicines.
Associate Professor Ylva Böttiger, Karolinska Institute and Karolinska University Hospital, made a presentation entitled Electronic prescription support systems – the role of clinical pharmacology. The data were drawn from a 1970’s Stockholm study involving a consultation service for patients with drug related problems [3]. A structured and evidence based evaluation of relevant literature were used over the years to provide the information for each patient consultation report. A similar drug evaluation model is used for building and maintaining the Finnish-Swedish point of care
Many of Folke Sjöqvist’s former foreign research fellows attended the honorary symposium.
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Research database, SFINX, which covers drug-drug interactions [4]. Currently SFINX contains approximately 15,000 drug-drug interactions and is available widely in electronic health records in both countries. The preparation of SFINX and other drug information databases provide new opportunities for clinical pharmacologists according to Professor Böttiger.
Professors Petra Thűrmann, HELIOS Klinikum Wuppertal, Germany, and Ulf Bergman, Karolinska Institute, emphasized that Folke Sjöqvist has always argued that academic clinical pharmacology will flourish only with daily involvement in clinical practice. They noted that because many clinical pharmacologists cannot, or do not, see patients regularly, the development of the field is compromised in Europe and elsewhere.
Personalised medicine and diagnostics
Professor Erik Eliasson, Karolinska Institute and Karolinska University Hospital, discussed Therapeutic Drug Monitoring (TDM) for tomorrow as a prerequisite for “personalised medicine”, a concept introduced by Professor Sjöqvist and his colleagues in the 1960’s [5]. Professor Eliasson reported that because TDM helps clinicians understand the variability in drug concentrations, it improves drug efficacy and safety in single patients and in vulnerable patient populations.
Professor Olof Beck, head of the Clinical Pharmacology Laboratory at Karolinska University Hospital, made a presentation entitled New technologies and monitoring tools in drug abuse and doping control. He believes that in the future mass spectrometry is likely to replace all immunological assay procedures. Today, it is possible to detect narcotic and internet drugs in exhaled air using smart collection devices and sensitive LCMS/MS detection techniques. He noted this technology has advanced rapidly since the first report in 2010 about the possibility of detecting amphetamine in exhaled air [6]. He also reported it is possible to detect numerous substances in small samples of fresh or dried blood using sensitive multiplex LCMS/MS technology.
The session co-chairs, Professors Michael Eichelbaum of Stuttgart Germany, and Leif Bertilsson of Stockholm, concluded that personalized medicine should be based on a combination of molecular, clinical and epidemiological approaches.
Ongoing research projects in clinical pharmacology in Sweden
Associate Professor Eleni Aklillu, Clinical Pharmacology at Karolinska
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Institute, presented her research results demonstrating differences in efavirenz concentrations between cohorts of HIV-patients in Ethiopia and Tanzania because of genotypic differences in the CYP2B6 drug metabolising enzyme activity [7]. Associate Professor Susanna Wallerstedt from the Clinical Pharmacology group in University of Gothenburg, Sweden, discussed Medication reviews – effects on hard outcomes and cost-effectiveness. She and her colleagues found in a randomized study that it is costly to conduct medication reviews using a pharmacist in hospitalized patients. The estimated cost of the intervention was equivalent to about €460,000 for each quality adjusted life-year (QALY) that is gained, supporting the view that medication reviews are not very cost-effective [8]. Associate Professor Björn Wettermark, Clinical Pharmacology at Karolinska Institute, emphasized the potential in Scandinavian countries of Pharmacoepidemiological research today and tomorrow. He found particularly valuable the results of analytical studies that combine data on drugs and drug therapy with information from other registers [9]. He predicted new opportunities for pharmacoepidemiological research across continents, given the growing interest in this field. The session co-chairs, Professors Giampaolo Velo, University of Verona, Italy, and Anders Rane, Karolinska Institute, Stockholm, concluded that scientific studies comparing the value and costs of drug therapies are major research avenues in clinical pharmacology.
Global medicine
Professor Gustafsson spoke of the Nobel Laureate, Professor Sune Bergström, describing him as a visionary who in the 1970’s initiated global, WHO-funded research programs on the clinical pharmacology and drug development of tropical diseases [10]. Gustafsson emphasized that public-private-non-profit partnerships such as the “Medicines for Malaria Venture” (MMV) and “Global Alliance for TB-drug development” have, since the end of the 1990’s, produced about 12 promising drug candidates that are now in phase II-III clinical trials. It was noted that global medicine is an area ripe for clinical pharmacology studies. He predicted that computerized decision supports systems will in a few years be critical for the delivery of healthcare in countries with limited resources.
Professor Michael Orme, University of Liverpool, United Kingdom, made a presentation entitled Quo Vadis? Presence and future of clinical pharmacology, the WHO initiatives and more that focused on the impact of Professor Sjöqvist’s impact on the development of clinical pharmacology [11]:•The 272 articles published by Professor Sjöqvist from 1994 to 2012 have been cited more than
10,000 times.•Professor Sjöqvist established clinical pharmacology as a multi-disciplinary clinical specialty
and directed its development in different areas, including clinical drug evaluation and pharmacogenetics.
•Between 1972 and 2005 as many as 112 individuals from 37 countries acquired a major part of their research training in Professor Sjöqvist’s department at Huddinge University Hospital and Karolinska Institute. Thirty-three of these trained in Stockholm between 1968 and 1996 have been become Professors of Clinical Pharmacology.
•Since 1971 Professor Sjöqvist has received a number of international awards in recognition of his work. He has also received honorary doctorates from institutions in five different countries.
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Research Professor Orme noted there have been challenges in the development of clinical pharmacology as an independent discipline. While he emphasized that clinical pharmacology must continue to be multidisciplinary, it needs to be recognized as a medical speciality, especially in Europe. He closed by stating that clinical pharmacology has much to offer, including information on the allocation of healthcare resources in the most cost-effective manner.
The identity of clinical pharmacology
The final session, chaired by Michael Rawlins and Professor Gunnar Alván, focused on the identity of the discipline. Michael Orme argued that clinical pharmacologists must have medical training to gain the trust and respect necessary for the discipline to flourish. Professor Sjöqvist ended the meeting by emphasizing the multidisciplinary nature of clinical pharmacology: Everyone is welcome, including pharmacists, analytical chemists, biostatisticians and geneticists. He argued that a dichotomy has developed between diagnosis and drug therapy. This can only be bridged by prescribers. It is necessary to understand the disease of the patient including psychosocial factors in pharmacotherapy. To gain an impact within health and healthcare you should be a physician when working as a clinical pharmacologist. Professor Sjöqvist reminded the group that he started as a general practioner. •
Sjöqvist Symposium(continued)
Folke Sjöqvist (left) and Michael Orme (right), who was awarded an honorary doctorate from Karolinska Institute a few days prior to the symposium.
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Folke Sjöqvist laughing with previous foreign research fellows at Clinical Pharmacology at Karolinska Institute
Sjöqvist Symposium(continued)
Professor Lars L. GustafssonProfessor Marja-Liisa Dahl, Head of Clinical DepartmentAssociate Professor Georgios Panagiotidis, Head of DivisionKarolinska Institute and Karolinska University Hospital, Stockholm, Sweden
References[1] A tribute to Folke Sjöqvist, 80. Eur J of Clin Pharmacol 2013;69:supplement 1[2] Malmström RE et al. Dabigatran - a case history demonstrating the need for comprehensive approaches to optimize
the use of new drugs. Front Pharmacol.2013;4:39. [3] Ohman B, Lyrvall H, Törnqvist E, Alván G, Sjöqvist F. Clinical pharmacology and the provision of drug information.
Eur J Clin Pharmacol 1992;42:563-7.[4] Böttiger Y, Laine K, Andersson ML, Korhonen T, Molin B, Ovesjö ML, Tirkkonen T, Rane A, Gustafsson LL,
Eiermann B. SFINX-a drug-drug interaction database designed for clinical decision support systems. Eur J Clin Pharmacol 2009;65:627-33.
[5] Hammer W, Sjöqvist F. Plasma levels of monomethylated tricyclic antidepressants during treatment with imipramine-like compounds. Life Sci 1967;6:1895-903.
[6] Beck O, Leine K, Palmskog G, Franck J. Amphetamines detected in exhaled breath from drug addicts: A new possible method for drugs-of-abuse testing. J Anal Toxicol 2010;34:233-7.
[7] Ngaimisi E et al, Burhenne J.Importance of ethnicity, CYP2B6 and ABCB1 genotype for efavirenz pharmacokinetics and treatment outcomes: a parallel-group prospective cohort study in two sub-Saharan Africa populations. PLoS One. 2013;8:e67946.
[9] Wallerstedt SM, Bladh L, Ramsberg J. A cost-effectiveness analysis of an in-hospital clinical pharmacist service. BMJ Open 2012;2:e000329.
[10] Wettermark B et al- The Nordic prescription databases as a resource for pharmaco-epidemiological research--a literature review. Pharmacoepidemiol Drug Saf 2013;22:691-9.
[11] Sune Bergstrom, Nobel Banquet Speech at http://www.nobelprize.org/nobel_prizes/medicine/laureates/1982/bergstrom-speech.html. Accessed May 23, 2013
[12] Orme M. Efforts and success world-wide in the field of clinical pharmacology. A personal review on the occasion of Folke Sjöqvist’s 80th birthday. Eur J Clin Pharmacol. 2013;69 Suppl 1:3-9
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ResearchOver the past year the GI Section was proud to host a number of successful meetings, including one in May, 2013 that included Dr. Barry Marshal, a Nobel Laureate. We look forward to organizing the GI symposia for the WCP2014 meeting in Cape Town. Other, more specialized, regional symposia are also being planned for the future.
Business and Scientific Meetings during the Digestive Diseases WeekIn May, 2013 the annual meetings of several American gastroenterology-related societies were held during the Digestive Diseases Weeks (DDW). The largest gathering of GI-related clinicians and basic scientists from all over the world, this meeting normally attracts more participants than GI world congresses. The IUPHAR GI Section meets regularly at these meetings, which are usually held in May. We are very proud that Dr. Barry Marshall, who shared the 2005 Nobel Prize for the discovery of Helicobacter pylori, the etiologic factor in the pathogenesis of ‘peptic ulcer’ disease, accepted our invitation to attend our meeting on May 19, 2013 in Orlando, Florida, USA. In addition to his presentation on “The
Dr. Barry Marshall participated in the May, 2013 Digestive Diseases Week in Orlando, Florida, USA.
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bad and good face of H. pylori: An update from the Ondek research team”. Dr. Marshall attended our business meeting dinner and actively participated in an extended discussion on various topics related to GI research, pharmacology, clinical activities, and the changing face of H. pylori.
15th Taishotoyoma International Symposium on Gastroenterology, Tokyo, Japan: Last of a SeriesThese symposia are organized and sponsored by the Taishotoyoma Pharmaceutical Co., Ltd. which produces and markets drugs, such as sofalcone, for the treatment of GI disorders. The first of these symposia was held in 1987 in Shimoda, a historic sea-side village near Tokyo, then the subsequent meetings have been held in Tokyo. As the number of participants is strictly limited, it is noteworthy that several members of IUPHAR GI Section leadership were invited to participate in past meetings, and the one held this year (September 26-28). The Organizing Committee chairs of the last several symposia have been two prominent GI investigators and clinicians from Japan, Profs. Masaki Kitajima and Akira Terano, who are also members of IUPHAR GI Section. Furthermore, four of the five Special Lectures were presented by members of the Global GI Club. Unfortunately, this will be the last of these symposia, as the company is unable to continue sponsorship of this event. The proceedings of this symposium will be published in the Journal of Gastroenterology and Hepatology.
Special IUPHAR GI Section Symposium: First in Zagreb, CroatiaThis meeting was held at the Medical Faculty, University of Zagreb, Croatia (October 17-19, 2013). It was organized by Prof. Predrag Sikiric of the University of Zagreb Department of Pharmacology, and a member of the International Board of IUPHAR GI Section. The program consisted of invited lectures, short oral presentations that were selected from submitted abstracts, poster sessions and round-table discussions. Most of the participants were from European countries, although there was also representation from Japan, Korea, Canada and the USA. The proceedings of this symposium will be published in the Journal of Physiological Pharmacology.
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IUPHAR GI Section Symposia at WCP2014 in Cape Town, South Africa (see page 24) The GI Section is very proud that its symposia proposals were accepted by the WCP Program committee. The GI topics to be covered during the Cape Town meeting (July 13-18, 2014) are:
• Advances in GI pharmacology: New approaches to upper and lower GI ulcers and inflammation
• Aspirin, the wonder drug: Keeping a balance between its great therapeutic benefits and its GI toxicity
• Hydrogen sulfide in GI health and disease
• Manipulation of gut microbiome as a treatment strategy for gastrointestinal and metabolic disorders
• Neuroendocrine regulation of GI protection: Central and peripheral pathways
These presentations are designed to appeal not only to basic and clinical scientists actively engaged in GI research, but to anyone interested current treatments for GI disorders, including functional and structural diseases. In addition, there will be a discussion of the latest developments in defining the pathology of GI diseases and new targets for drug discovery. In addition, the GI Section will have its quadrennial business meeting on Sunday afternoon, July 13, just prior to the opening ceremony of the Congress.
8th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection, September 24-26, 2014, Budapest, Hungary (see page 51)This is the eighth in a series of international symposia, with the first one was held in Heidelberg, Germany in 1986. This gathering is now the official scientific meeting of IUPHAR GI Section. Unlike the terminated Taishotoyoma International Symposia on Gastroenterology that focused on broad scientific and clinical aspects of GI diseases, these meetings are more focused on particular issues of contemporary interest, such as the pharmacologic prevention of GI lesions (i.e., protection of GI tract), especially on gastroprotection. The value of these symposia is enhanced by parallel presentations and discussion on mechanisms of cell and tissue injury in the GI tract and other organs. This fosters a cross-fertilization of ideas that is enhanced by specialists and presentations in areas such as cardioprotection, neuroprotection and hepatoprotection. Such interactive presentations will highlight the 2014 meeting in Budapest. The symposium is being organized by Prof. Klara Gyires of the Department of Pharmacology, Semmelweis Medical University, who is also a member of the IUPHAR GI Section Executive Committee, and her colleagues. It will be held in the historic building of the Hungarian Academy of Sciences. •
Sandor SzaboPresident, IUPHAR GI Section
Past & Future Activities of the IUPHAR Gastrointestinal (GI) Section
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Standing Committee J. Farber S. Orrenius S. Szabo A. Tarnawski K.H. Usadel
Scientific Advisory Board T. Brzozowski (Poland) L. Filaretova (Russia) L. Lichtenberger (USA) G. Mózsik (Hungary) K.D. Rainsford (Great Brittan) A. Somogyi (Germany) Y. Tache (USA) K. Takeuchi (Japan) J. Wallace (Canada)
Local Organizing Committee: K. Gyires (Chair) B. Sperlagh (Co-chair) P. Ferdinandy P. Matyus A. Vas Z. Zádori (Secretary)
Organized by: -Hungarian Society for Experimental and Clinical Pharmacology - Department of Pharmacology and Pharmacotherapy, Semmelweis University - Drug Development and Safety Center
Sponsored by:
Hungarian Academy of Sciences IUPHAR GI Section
FIRST ANNOUNCEMENT
8th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection
24-26 September, 2014 Budapest, Hungary
Goals To provide updates on cell & tissue injury, as well as protection. The focus will be on
gastrointestinal (GI) tract – injury & protection of esophageal, gastric, duodenal mucosal injury & ulcers, brain-gut & gut-brain axis, liver damage, inflammatory bowel disease, irritable bowel syndrome, role of microbiota in intestinal mucosal homeostasis, & the role of progenitor-stem cells in healing. Moreover, mechanism of cell/tissue injury & cyto/organoprotection of other tissues (e.g., cardiovascular, liver, central & peripheral nervous system) will also be discussed.
Main topics Advances in GI pharmacology Novel insights into the mechanisms of GI mucosal injury & protection Mechanisms of NSAID-induced tissue injury Mechanisms of H. pylori-induced tissue injury Prostaglandins, antioxidants, gas mediators & growth factors in GI mucosal protection Mechanisms of reversible & irreversible cell injury Stem cells & microRNAs in cell injury & cytoprotection Neurotransmitters, hormones & peptides in gastric in gastric mucosal injury/protection
Microbiota & intestinal homeostasis Probiotics & nutraceuticals Hepatic injury & protection Cardioprotection Neuroprotection: novel target sites & protective mechanisms
Format Minisymposia, e.g., 2-4 invited speakers, followed by short presentations
selected from submitted abstracts Poster session
Registration fees (before 1st June, 2014) Individuals: 295 Euro (includes program & abstract booklet, opening Reception, coffee breaks, lunches, organ concert) Students/fellows: 95 Euro Corporations/industry: 595 Euro
For further information please contact:Symposium Chair: Prof. Klara Gyires, e-mail: [email protected] Symposium Secretary: Dr. Z. Zádori, e-mail: [email protected]
Department of Pharmacology & Pharmacotherapy, Semmelweis University, Budapest
Symposium Co-chair: Prof. B. Sperlagh, e-mail: [email protected] Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest
Past & Future Activities of the IUPHAR Gastrointestinal (GI) Section
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IUPHAR is a 3rd party to the EU 7th Framework funded Network of Excellence project called the Global Research in Pediatrics (GRIP). The fostering of training in pediatric clinical pharmacology is one of the main objectives of the GRIP program (for more information, see Pharmacology International 2011; No. 76 [June] p. 3). To this end, the GRIP Roadshow has been developed as a collaboration between the European Society for Developmental, Perinatal and Pediatric Pharmacology (ESDP), an IUPHAR member society, and the IUPHAR Pediatric Clinical Pharmacology Section.
Concept
GRIP Roadshow is a one to two day face-to-face introductory course that covers pediatric clinical pharmacology and the challenges associated with investigation medicines for children. The course content was developed in a workshop composed of leading experts in pediatric clinical pharmacology that was held in Rotterdam in October, 2012. The workshop participants developed course materials, including slides, covering a series of selected key topics. Other experts and institutions, such as the European Medicines Agency (EMA), provided additional content for the course. The content package is customized for individual courses based on the length of time available and the audience. By the end of a Roadshow course the participants will 1) be able to describe how children handle medicines differently than adults; 2) recognize the need for appropriate formulations and data on doses, efficacy and safety to ensure high-quality drug therapy; and 3) be aware of the importance of clinical trials in providing children with better medications and for reducing pediatric off-label use.
A Roadshow course is delivered by two experts in pediatric clinical pharmacology either as a stand-alone course or as part of another meeting or congress. As GRIP covers all of the speakers’ expenses, there is no cost to the host institution or society. The local organizers are responsible for advertising the course and registering participants. Local organizers are welcome to use the registration fees to help cover the costs associated with sponsoring the event.
Three Pilot Courses in 2013
The Roadshow concept was piloted in 2013. Dr. Marek Migdal organized the first one on February 25-26 in Warsaw, Poland. There were 38 participants. The tutors were Drs. Stephanie Laer, Secretary General of ESDP, from Dusseldorf, Germany and Saskia de Wildt from Rotterdam, Netherlands. The second Roadshow was held as a pre-congress Education Day in conjunction with the 14th Biannual ESDP Congress in Salzburg, Austria. The course was presented on June 4th, with approximately 60 participants. The tutors for this one-day course were Drs. John van den Anker, from Washington D.C., USA and Gregory Kearns, from Kansas City, Missouri, USA. In August, a Roadshow
GRIP Training:From the IUPHAR Section on
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GRIP Training in Pediatric Clinical Pharmacology(continued)
Program of the GRIP Roadshow in Salzburg, Austria on June 4th, 2013
Time Topic9:00-9:30 Welcome and introduction to the course and to GRIP9:30-10:00 General introduction to the theme of the course
• The concept of children as “Therapeutic orphans” • Off-label and unlicensed use of medicines in children • The pediatric initiatives (US, EU, WHO)
10:00-11:00 Basics of developmental/pediatric pharmacology• Birth to adulthood, pharmacodynamics and pharmacokinetics • Considerations of dose calculation• Routes of administration in children
11:00-11:30 Break11:30-12:00 Drug safety in children
• Are adverse effects more common or more rare in children? • Adverse effects related to or affecting growth and development • Dosing errors
12:00-12:300 Pharmacological aspects in case of severe disease in children in relation to the pharmacodynamics and pharmacokinetics
12:30-13:30 Lunch13:30-14:30 Pediatric formulations
• Formulations most suitable for use in children• Considerations of excipients used in pediatric formulations• Extemporaneous formulations
14:30-15:00 When evidence is absent can we extrapolate data from adults to children or should we do clinical trials?• Off-label or off-knowledge use of medicines?• Experimental therapy vs. clinical trials
15:00-15:30 Ethical aspects of drug research in children15:30-16:00 Break16:00-16:30 Understanding the basics of drug development in children
• Finding the right dose• Demonstrating efficacy• Demonstrating safety• Regulatory assessment and why it is important
16:30-17:00 What you need to know as an investigator of a pediatric clinical trial• What is a good study and what is not• Good Clinical Practice (GCP)• Recruiting children for a study• Protocol deviations• Adverse Events
17:00-17:30 Questions and General Discussion
17:30-18:00 Summary and closing of the meeting (including evaluation)Continued on page 60...
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GRIP Training in Pediatric Clinical Pharmacology(continued)
was organized within the program of the International Congress of Pediatrics 2013 in Melbourne, Australia. Dr. Kalle Hoppu, from Helsinki, Finland and Gregory Kearns were the tutors. Approximately 70 to 80 individuals attended the entire course, with up to 130 present at any given time.
The participants were asked to assess the training in relation to the learning objectives. The results for those who returned the questionnaire after the Warsaw and Melbourne courses were as follows: for those who considered that the three main learning objectives were completely / somewhat achieved for learning objective 1: 60% / 40%, for learning objection 2: 80% / 20%, and for learning objective 3: 87% / 13%.
The experience gained from the three pilot courses has been invaluable, and encouraging, for both the participants and the tutors. As compared to a conventional course, which typically involves different speakers for each topic, the audience sees the Roadshow tutors more as teachers than simply speakers. The broad spectrum of topics covered by the tutors reinforces their expert status in the view of the participants.
Future Plans
Roadshows in France, Finland, Argentina and/or Chile, India and possibly South Africa and some Eastern European countries are being considered for 2014. The pool of tutors will have to be expanded to meet the growing demand for this course. While the GRIP project is scheduled to run through 2015, a one-year extension of this program is under consideration. If the Roadshow concept proves its value, it may be continued by ESDP and/or IUPHAR once GRIP support is terminated. IUPHAR member societies, particularly regional ones, interested in organizing a stand-alone Roadshow course or one in conjunction with their annual meeting are encouraged to contact the IUPHAR Office for further information. •
Kalle HoppuChair, IUPHAR Section of Pediatric Clinical PharmacologyLeader of GRIP WP1
See pages 16 and 26 for the WCP2014 symposia offered by the IUPHAR Section of Pediatric Clinical Pharmacology!
Tutors and participants at the first GRIP Roadshow in Warsaw, Poland, February 25-26, 2013. The tutors were Drs. Stephanie Laer, Kalle Hoppu, and Saskia de Wildt, who are seated in the front row from left to
right, and Dr. Marek Migdal, who is standing furthest to the right.
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News from the IUPHAR Section of Pharmacogenetics and Pharmacogenomics
Memorandum of Agreement between IUPHAR PGx and ESPTIn March 2013, Prof. Gérard Siest, President of European Society for Pharmacogenetics and Theranostics, and Ingolf Cascorbi, Chair of the IUPHAR Section of Pharmacogenetics and Pharmacogenomics, signed a memorandum of agreement to cooperate and collaborate on programs and activities of mutual interest.
2nd ESCPT conference, September 26-28, 2013, Lisbon, PortugalThe initial activity undertaken by these groups, and sponsored by IUPHAR, was the 2nd Conference of the European Society of Pharmacogenomics and Theranostics Pharmacogenomics “From Cell to Clinic”. This three day meeting was well organized and well
attended. Presentations covered a broad range of topics relating to pharmacogenetics, and included workshops describing new technologies. Five members of the society were invited to give oral presentations. Ann K. Daly, Newcastle, U.K, presented a talk entitled Recent progress in molecular methods for pharmacogenomic studies in which she highlighted intriguing findings on the association between drug-induced liver injury and the HLA-marker. Magnus Ingelman-Sundberg, Stockholm, Sweden, made a presentation entitled Pharmacogenomics of endogenous metabolism and its implication for behaviour, psychopathology and treatment which underscored the importance of CYP2C19 for proper brain development. In his presentation entitled Prospective clinical trials on courmarin anticoagulant pharmacogenomics: The moment of truth, Vangelis G. Manolopoulos, Alexandroupolis, Greece, outlined the EU-wide EUPACT consortium. It was announced that the results of this work will be presented in November 2013 at the American Heart Congress. Matthias Schwab, Stuttgart, Germany, gave a presentation entitled The importance DNA methylation and its impact on transporter PGx focusing on the human lactate transporter MCT4 in renal cancer and itsconsequences for clinical outcomes. Ingolf Cascorbi, Kiel, Germany, reported on miRNA and its impact on ABC transporter-mediated drug resistance, highlighting the interaction of miRNA with ABCC2 and ABCG2 expression and its differential influence on variant alleles. On the second day of the conference the IUPHAR PGx Section held a special workshop on Global status of clinical implementation of pharmacogenomics: A brief survey, which was underwritten by IUPHAR and the IUPHAR Clinical Division in order to highlight the role of PGx in clinical medicine. This workshop fostered a lively discussion among the speakers and attendees. In particular, Guilherme Kurtz-Suarez, Rio de Janeiro, Brazil, contributed to the discussion by outlining the situation in South America involving mixed populations. Conference participants came from both academia and industry. The aim of this workshop was to provide a brief overview of the symposium the PGx Section is planning to present during the 17th World Congress of Basic and Clinical Pharmacology in Cape Town in July, 2014.
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5th International Congress on Psychopharmacology
The 5th International Congress on Psychopharmacology (TAP-ICP) was held in Antalya, Turkey from October 30th to November 3rd, 2013. As in 2011, this congress was held under the auspices of IUPHAR. The IUPHAR PGx Section was kindly invited by Prof. Feyza Aricioglu, Marmara University, Istanbul, to organize a symposium on personalized medicine in psychiatry. The speakers were Professors Alessandro Serretti, Bologna, Italy; David Gurwitz, Tel Aviv, Israel; Ingolf Cascorbi, Kiel, Germany; and Julia C. Stingl, Bonn, Germany.
17th World Congress of Basic and Clinical Pharmacology (WCP2014)The PGx Section is organizing two symposia during WCP2014. The first is entitled Epigenetic regulation of drug metabolizing enzymes and transporters (see page 16 for details) scheduled from 10:30 a.m. to noon
on Monday, July 14th. It will feature Ingolf Cascorbi, Magnus Ingelman-Sundberg and Igor Pogribny to address such aspects as DNA methylation and the role of microRNAs in the regulation of drug metabolism as well as the implications of modulation of gene expression by microRNAs. The second is entitled Global PGx-based personalized medicine and features perspectives from Julie Johnson (North America), Guilherme Kurtz-Suarez (South America), Collen Masimirembwa (Africa), Andrew Somogyi (Australia), Ingolf Cascorbi (Europe), Adrian Llerena (Global Health) and Vural Özdemir (Public Health). It will be held 3:30 - 5 p.m. on Wednesday, July 16th (see page 23 for details). Please add these symposia to your itinerary! •
Ingolf CascorbiChair, Pharmacogenetics/genomics Section
News from the IUPHAR Section of Pharmacogenetics
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Member UpdatesA Galaxy of Pharmacologists and an
Exhibition of PharmacologyThe 12th Meeting of the Asia-Pacific
Federation of PharmacologistsHosted by the Chinese
Pharmacological SocietyThe 12th meeting of the Asia-Pacific Federation of Pharmacologists (APFP) was held in Shanghai, China, from July 9 to 13, 2013. It was sponsored by the Chinese Pharmacological Society (CNPHARS) and the APFP, and co-sponsored by the Second Military Medical University and Shanghai Pharmacological Society. The chair of the meeting was Prof. Guan-Hua Du, President of CNPHARS. The purpose of the meeting was to enhance international collaborations in pharmacology to facilitate drug discovery and development, to improve clinical care, and to enhance pharmacology instruction.
The meeting attracted over 1,200 participants, mostly from Asian and Pacific rim countries, including China, Hong Kong, Taiwan, Japan, Korea, Singapore, Thailand, Malaysia, and Australia. Some invited experts from the USA, UK, South Africa, Hungary, and Belgium were also in attendance. Among the many famous pharmacologists who were present were Prof. S. J. Enna, Secretary-General of IUPHAR, Prof. Masamitsu Iino, Vice-President of IUPHAR, Prof. Douglas Oliver, Councillor of IUPHAR and President of the 17th World Congress of Basic and Clinical Pharmacology, Prof. John Miners, Councillor of IUPHAR, Prof. Akos Mathe, Vice-President of International
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ResearchCouncil for Medicinal and Aromatic Plants, Prof. Samuel HH Chan,President of APFP, Prof. Masayoshi Mishina, President-elect of APFP, Prof. Alastair Stewart, Secretary General of APFP, Prof. Wen-Chang Chang, Councillor of APFP, Prof. Peter Molenaar, Councillor of APFP, Prof. Supratra Srichairat, Councillor of APFP. Officials of CNPHARS who participated the meeting included Prof. Zhi-Bin Lin, Honorary President of CNPHARS and Councillor of APFP, Prof. Guan-Hua Du, President of CNPHARS and Councillor of APFP, Prof. Yong-Xiang Zhang, Secretary-General of CNPHARS and Councillor of IUPHAR, and the Vice-Presidents of CNPHARS, Prof. Jian Ding, Bao-Feng Yang, Xue-Jun Li, Xiu-Mei Zhang, Jun-Tian Liu, Wei Wei and Jian-Guo Chen.
The opening ceremony was held in the evening and presided over by Prof. Yong-Xiang Zhang, the Secretary-General of the meeting. Prof. Guan-Hua Du, the chair of meeting, delivered a welcoming speech on behalf of the meeting organizers, after which there were brief speeches by Prof. Samuel HH Chan, the President of APFP, Prof. S. J. Enna, Secretary-General of IUPHAR, and Prof. Ying-Hao Sun, the President of the Second Military Medical University. Subsequently all of the distinguished guests joined the meeting organizers on stage where they launched the fireworks, signaling the opening of the meeting. The meeting hall was filled with the sound of exploding fireworks, cheering and laughter. Colorful ribbons danced in the air. The atmosphere was very warm and cheerful. While brief, the opening ceremony was very moving and warmly received by the audience.
The meeting included 10 plenary lectures spanning two sessions (photograph above). Prof. S.J. Enna presented a lecture on GABA receptor allosterism; Prof. Samuel HH Chan reported on brain-derived neurotrophic factor (BDNF) as an endogenous antioxidant in animal models of disease; Prof. John Miners on the structure-function relationships of human UDP-glucuronosyltransferases: application of molecular,
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kinetic and computational modeling approaches; Prof. Douglas Oliver discussed guanidines pharmacology from molecule to primate; Prof. Jian-Guo Chen reported on how the stability of NR2B in the nucleus accumbens controls behavioral and synaptic plasticity adaptations to chronic stress and amphetamine; Prof. Masamitsu Iino reviewed his work on the regulation of cell functions by Ca2+: From basic principles to therapeutic targets; Prof. David Webb presented a lecture on therapeutic target of endothelin and nitric oxide in hypertension and chronic kidney disease; Prof. Akos Mathe reviewed current trends in the study of MAPs and their clinical uses; Prof. Alastair Stewart reported on glucocorticoid insensitivity in chronic inflammatory diseases, and Prof. Min-Goo Lee presented work on human ABC transporters and pharmacogenomics. Others described their research in 12 symposia. Topics including antitumor pharmacology, neuropsychopharmacology, drug discovery and pharmaceutical screening, natural products and traditional medicines, therapeutic drug monitoring, chemotherapy, cardiovascular pharmacology, and drug metabolism.
Young scientists participated in oral presentation (photograph below) and poster session competitions (photograph at right). The winning entries, which were judged on the basis of the quality of the research, the clarity of the report, and responses to questions, were selected by a jury of senior scientists. There were ten winners selected from the oral competitions and 50 from the poster presentations. The awards were presented at the closing ceremony.
Two joint meetings were held during the 12th Meeting of APFP. These were the Second Joint Symposium on Pharmacology of Chinese Pharmacological Society and British Pharmacological Society (BPS), and the 2013 Joint Meeting of Pharmacology of Chinese Pharmacological Society and Hong Kong Pharmacology Society (HKPS).
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During the CNPHARS-BPS joint meeting, 16 pharmacologists selected by CNPHARS or BPS
made presentations on the themes of State-of-the-art in mechanisms and treatments of neurodegenerative
diseases and Recent advances in cardiovascular pharmacology. The presenters from China included Prof. Zhong Chen (Histamine H3 receptor aggravates cerebral ischemic injury by non-histaminergic mechanisms), Prof. Lin Li (Beneficial effects of tetrahydroxy-stilbene glucoside on multiple targets of Alzheimer’s disease), Prof. Jia-Wei Zhou (The role of astroglia in Parkinson’s disease), Prof. Lan Zhang (Beneficial effect of cornel iridoid glycoside on neural protection and regeneration), Prof. Yi-Fan Han (Neuroprotection through multiple targets by novel anti-Alzheimer’s dimers derived from Chinese medicines), Prof. Rong-Biao Pi (Evaluation of tacrine-caffeic acid heterodimers as multi-targeted anti-Alzheimer’s disease agents and the mechanism of anti-oxidative stress), Prof. Bao-Feng Yang (Role of microRNAs in heart diseases and translational research), Prof. Yong Ji (Gas molecules as regulators in cardiovascular pharmacology), Prof. Yu Huang (Vascular oxidative stress against nitric oxide bioavailability), Prof. Xue-Jun Li (Autophagy mediates the cytoprotective mechanism of polyphenols), and Prof. Jun Peng (Phosphorylation of nuclear myosin II and myocardial ischemia-reperfusion oxidative injury). Those from the United Kingdom were Prof. Mimoun Azzouz (Prospects for success in gene therapies for motor neuron diseases), Prof. Sandor Kantor (Sleep and EEG as biological markers in animal models of Huntington’s disease), Prof. Ruth Luthi-Carter (Merging multi-modal ‘omics data to benefit drug discovery), Prof. Derek Terrar (Calcium signalling in the heart and its regulation by endogenous mediators), and Prof. Xin Wang (Exploring therapeutic potential of the immunomodulator fingolimod (FTY-720) for treating cardiac hypertrophic remodeling). By promoting this exchange of information on neurodegenerative and cardiovascular diseases between Chinese and British pharmacologists, this meeting created opportunities for future collaborations between the CNPHARS and the BPS.
The 2013 joint meeting of CNPHARS and the Hong Kong Pharmacology Society was designed to encourage communication and collaboration among young mainland pharmacologists and those in Hong Kong. A young investigator oral presentation competition was held during the meeting. Of the 14 Ph.D. students selected to compete, six won awards for best presentations. Both societies believe the development of pharmacology in China will be facilitated by strengthening the research bond between young scientists on the Chinese mainland and in Hong Kong.
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Also held during the CNPHARS meeting were the 17th Servier-CNPHARS Outstanding Young Pharmacologist Award (photograph above) and the 2013 CNPHARS Outstanding Young Pharmacologist Award ceremonies. The CNPHARS meeting succeeded in encouraging communication and collaboration among basic and clinical pharmacologists in the Asia-Pacific region. The meeting fostered a lively exchange of ideas, and provided an excellent platform for the presentation of research results and new techniques in pharmacology. Feedback from the delegates indicated the meeting was a great success that contributed greatly to the advancement of pharmacology worldwide. It was agreed that the momentum generated by this event must be maintained by more frequent communication among scientists and by further interactions at similar types of productive, high level conferences.•
Yong-Xiang ZhangSecretary, CNPHARS and Councillor, IUPHAR
APFP Meeting(continued)
The APFP closing and award ceremony
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The 75th anniversary of the Italian Society of Pharmacology (SIF: Società Italiana di Farmacologia) will be on December 22nd, 2014. On that day in 1939, royal decree no. 2162 (at that time Italy was a kingdom) was issued and officially established the Society. The first congress was held in Florence a year later on December 20th - 22nd, 1940. The 75th birthday was celebrated at the 36th biannual National Congress in Turin on October 23rd – 26th, 2013.
We are grateful to IUPHAR for offering us the opportunity to share the celebration with our sister pharmacology societies. Only the American, German and British pharmacological societies are older that the Italian Society. In 1939 a small group of Italian pharmacologists, led by Gaetano Vinci, of the University of Messina and a member of the Italian Senate, launched SIF. Professor Vinci was elected the first president of the Society. At that time the founding members declared that “the time had come for the Italian pharmacologists to recognize themselves as a family with a uniformity of scientific interests and a spirit of true collegial friendship”. The Society was born at a difficult time inasmuch as World War II had begun a few months earlier. Moreover, the Facist regime had imposed limitations with regard to foreign travel and contacts with foreign colleagues, causing cultural and scientific isolation. Nevertheless, the SIF founders were optimistic and determined, holding the second and third congresses as scheduled in 1942 and in 1944 despite the war. Indeed, the 1944 congress was held in Florence shortly after the city was liberated from the German army.
While there were approximately 50 original members, after the war and reconstruction the membership grew to 200 in 1963, 550 in 1974, then 1,075 in 1994. Today, there are about 1,200 members. The bylaws were modified over the years in response to the growth of the Society and to adapt to changes in academia, industry and the healthcare system. The Society is administered by a President, presently Professor Francesco Rossi, Second University of Naples, who is assisted by the Past President, Professor Pier Luigi Canonico, University of Eastern Piedmont, Novara and the President-Elect, Professor Giorgio Cantelli Forti, University of Bologna, as well as a Secretary and a six-member Executive Council. The President is elected for a 2-year term. The presidents who served over the past decade were the Professors Vincenzo Cuomo (1999-2003), Rome University “La Sapienza”, Gian Luigi Gessa (2003-2005), Giovanni Biggio (2005-2007),University of Cagliari, and Achille Caputi (2007-2009), University of Messina. The Society maintains a permanent office in Milan that is managed by an administrative secretary. Society revenues are derived from membership dues, corporate contributions, and profit from courses and meetings. A large portion of the annual budget is invested in fellowships and travel grants for doctoral students and postdoctoral fellows.
THE 75TH ANNIVERSARY
OF THE ITALIAN SOCIETY OF
PHARMACOLOGY
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At its first Congress, the Society adopted as its official journal the existing Archivio Italiano di Scienze Farmacologiche, which was founded in 1932. As it was published only in Italian, it had limited distribution. Some members published their work in foreign journals, mainly the Archiv für Pathologie und Experimentelle Pharmacologie, the Archives Internationelles de Pharmacologie et Pharmacodynamie and, rarely, in the Journal of Pharmacology and Experimental Therapeutics. The Archivio was discontinued in 1969 and replaced by Pharmacological Research (for more information please visit http://www.sifweb.org/ricerca/pharm_res.php), which is published in English.
The comparison of the proceedings of the first SIF congress held in 1940 with the program of the 36th Congress in 2013 demonstrates clearly the growth of the Society and the changes in the field over the past seven decades. Thus, the first congress included two lectures and 46 oral presentations. Only the lecture presented by Professor Vittorio Erspamer (photograph at left), the discoverer of serotonin with Irvine H. Page, and of many pharmacologically active peptides from amphibian skin, reached an international standard and is still interesting to read because of its remarkable insights.
At the 2013 Congress there were two guest lectures, 41 symposia, 20 sessions of oral presentations, many workshops, and hundreds of posters. Because of attendance by foreign colleagues, many presentations wiere in English. Topics like “personalized medicine,” economic sustainability of pharmacological treatments, clinical pharmacology, public health and nanomedicine demonstrate the breadth of Society interests in the 21st century. From a learned society focused on the dissemination of experimental results, the SIF has evolved into one that provides a forum for the presentation of high quality experimental results and for discussion of issues associated with drug development and the use of therapeutics within the context of the national health system.
The SIF was significantly affected by the extraordinary economic, social, and cultural changes that occurred in Italy for several decades after the war. During this time Italian universities increased in size and number, and more money was invested in research, although the amount of funding never matched the amount needed to support all the worthwhile studies. Many PhD students and postdocs went abroad for study, mostly to the United States. Those who returned to Italy introduced new ideas and new laboratory techniques. They also brought a new management style to the stagnant Italian university system, helping it to shed its provincial atmosphere. Two Nobel laureates, Daniel Bovet and Ernst Chain, were appointed as Chief of the Laboratory of Therapeutic Chemistry and of the Center of Microbiological Chemistry, respectively, at the Istituto Superiore di Sanità, Rome. Their presence was inspiring and encouraging for young Italian pharmacologists. The expansion and success of the international and Italian pharmaceutical industries also help grow the SIF by providing financial support for young graduates, university grants, and by helping to foster a stimulating scientific environment.
In September 1968, the 1st Joint Meeting with the British Pharmacological Society, considered a model to imitate by the young Italian pharmacologists, was held in Florence. For the first time at a SIF meeting, the presentations
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The pre- and post-doctoral students who received an award at the National Congress of the Society, held in Turin on October 23rd - 26th, 2013.
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were selected by referees and presented in English. Between 1968 and 2003 there have been 24 joint meetings held with the French, German, Dutch, Belgian, Scandinavian, Polish, and Hungarian societies. These gatherings have created a large network of scientific collaborations, and helped stimulate the creation of the Federation of European Pharmacological Societies (EPHAR), which is presently chaired by Professor Filippo Drago, Catania University.
The SIF joined IUPHAR early and has been continuously involved in IUPHAR activities. Professors Rodolfo Paoletti and Paolo Preziosi served as IUPHAR councillors in 1975 - 81 and 1994 - 98, respectively. Professor Giancarlo Pepeu was elected auditor 1998 - 2000, and Professor Gian Paolo Velo of Verona and Professor Emilio Perucca of Pavia served as councillors of the IUPHAR Clinical Division from 1992 - 2000 and 2000 - 2008, respectively. Professor Velo, together with Professor Pepeu, organized the 7th World Conference on Clinical Pharmacology & Therapeutics in Florence in 2000.
The SIF website, http://www.sifweb.org, provides details on the organization of the Society, which includes a Division of Clinical Pharmacology. The SIF fosters scientific interactions among its members through ten working groups, covering virtually all aspects of pharmacology. The Society supports young pharmacologists with travel fellowships and grants and assists them in identifying job opportunities. The SIF collaborates with public authorities and private organizations in disseminating expert opinions on drug efficacy and side effects. In this regard, the Society also oversees a website on pharmacovigilance, http://www.farmacovigilanza.org, which is very popular among general practitioners. The SIF activities are regularly announced in Quaderni della SIF, a quarterly magazine, and in three on-line publications: the weekly SIF Newsletter, the bi-weekly Drugs in Evidence”, and a Pharmacogenetics Bulletin. The Society sponsors and awards prizes for the best publications in different areas of pharmacology. These awards are funded by the Association of Pharmaceutical Industries (Farmindustria), pharmaceutical companies and private foundations. Besides its biennial National Congresses, the Society organizes small meetings on specific topics. In addition, since 1997 it has hosted an annual National Seminar for PhD students of pharmacology and related disciplines in which they have an opportunity to present and discuss their research with each other and their tutors.
Since its founding, the Society’s scientific activities have been summarized in three articles: “La Ricerca Farmacologica Italiana 1930 - 40, 1946 - 68, and 1968 - 90” by Giancarlo Pepeu in Quaderni della SIF. These historical summaries, which are written in Italian, are available on the Society’s website. Most members are active and publish regularly in journals of pharmacology and related disciplines such as neuroscience, molecular biology, and biochemistry.
Up to now the European economic crisis, which for many reasons is more severe in Italy than in other countries, has not affected Society activities. However, because there is now less public and private funding for research, young scientists are being discouraged from pursuing their profession. Thus, as compared to earlier times there are fewer new university and industrial positions for pharmacologists. For this reason many leave Italy in search of opportunities. Thus, the Society is celebrating its 75th birthday in challenging times. However, as the need for new medications will grow, there is no doubt that Italian pharmacology will weather the current storm in paving the way for a gala celebration of its 100th anniversary in 2039. •
Giancarlo PepeuSIF President 1995 - 1999
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2014 AnniversariesIUPHAR congratulates these member societies on their Milestone Anniversaries:
Italian Society of Pharmacology1939 - 2014
Czech Society for Experimental and Clinical Pharmacology and Toxicology
1959 - 2014
Slovak Pharmacological Society 1959 - 2014
American College of Clinical Pharmacology 1969-2014
Indian Pharmacological Society1969 - 2014
Portuguese Society of Pharmacology 1969 - 2014
Canadian Society of Pharmacology and Therapeutics
1974 - 2014
Croatian Pharmacological Society1979 - 2014
Hellenic (Greek) Society of Pharmacology 1984 - 2014
Serbian Medical Society Section on Clinical Pharmacology
2009 - 2014
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Dear Colleague,
On behalf of the International Union of Crystallography (IUCr), we are pleased to invite you to attend the official Opening Ceremony of the International Year of Crystallography (IYCr2014), which will take place at UNESCO Headquarters in Paris on 20 and 21 January 2014. The IUCr and UNESCO are leading the celebration of IYCr, which was proclaimed by the United Nations General Assembly in July, 2012.
The Opening Ceremony will provide an exciting opportunity to demonstrate the many aspects of crystallography. Events planned for the Ceremony include presentations, a round-table discussion involving young crystallographers and an exhibition. Full details of the programme may be found at http://www.iycr2014.org/opening-ceremony.
We hope that you will be able to join us for the Opening Ceremony. Note that registration for the event is free, but as places are limited, entry will be assured only by prior registration. We invite you, therefore, to register for the Opening Ceremony by visiting http://www.iycr2014.org/registration. The deadline for registration is 3 November 2013.
Finally, please feel free to extend this invitation to one accompanying person (note that a registration form should also be completed for this person). If you have any problems with the registration procedure, please contact the International Basic Sciences Programme of UNESCO at [email protected]. •
Yours sincerely,
Michael H. Dacombe and Michele ZemaExecutive Secretary Project Manager for the International Year of Crystallography 2014
IUCr, International Union of Crystallography Abbey Square, Chester CH1 2HUUnited KingdomPhone: +44 (1244) 342 878Fax: +44 (1244) 314 888E-mail: [email protected]
http://www.iucr.orghttp://www.iycr2014.orghttps://www.facebook.com/iycr2014.org
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The training course will take place at the Hotel Dubrovnik, Zagreb
Time
The course will start on 03 April at 08.30 through to 17.00 and continue on 04 April at 09.00 through to 17.00 (1 hour lunch)
Practical information, Programme
and Registration forms available from the ISoP Administration office: ISOP SECRETARIAT LTD 140 Emmanuel road London SW12 0HS Ð UK Tel/Fax: +44 (0)20 3256 0027 e-mail: [email protected] website: www.isoponline.org
The International Society of Pharmacovigilance, an international non-profit scientific society, gratefully acknowledges assistance from the Agency for Medicinal Products and Medical Devices of Croatia (HALMED)
as partner co-organizer.
ISoP Training
Course Zagreb
03-04 April 2014
Proactive Pharmacovigilance and Risk Management in the Era
of Personalised Medicines
First Announcement
ISoP training course Ð Zagreb, 03-04 April 2014 Proactive Pharmacovigilance and Risk Management
in the Era of Personalised Medicines Recent changes in the pharmacovigilance legislation in various regions in the world have introduced mandatory elements to pharmacovigilance practice, some of which are new, others, still existing, have been developed further. In this advanced two day-seminar, two important elements will be elucidated, with a focus on proactive risk management and the role of rapidly evolving pharmacogenomics in pharmacovigilance. The training course will be offering opportunity for open discussions and thoughts on how to fill empty spaces in good pharmacovigilance practice. There will be ample opportunity to exchange views and ideas in discussions both following individual presentations, after the panel discussion at the end of the seminar, and during coffee breaks. This course is targeted at regulators, scientists and industry, with a strong focus on practical examples and real-life solutions. The faculty for this course consists of international experts in pharmacovigilance, representing government, academia, and industry.
The programme will include the following topics:
¥ Medical assessment of adverse drug reactions (ADRs)
¥ Evaluating and minimising risk and medication errors through RMPs, PASS and other activities in the post-authorisation phase
¥ Risk minimisation measures in Risk Management Plans (RMP); selection of tools and effectiveness indicators, and communication
¥ Evaluation of Post-Authorisation Safety Studies (PASS)
¥ Best practice of literature assessment as an everyday practice in pharmacovigilance
¥ Medication errors: definition, reporting and assessment
¥ The safety of the individual patient and how will pharmacovigilance respond to new drug developments
¥ Pharmacogenomics and safety of drugs ¥ The role of patient groups in pharmacovigilance ¥ Establishing a benefit-risk balance in orphan
drugs This course is organized in the historic city of Zagreb, capital of the newest member of EU, Croatia.
First Announcement
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11th Meeting of the International Society for Serotonin Research
WCP2014 Satellite: A Serotonin Safari
Arabella Hotel and Spa, Kleinmond, Hermanus, Western Cape, South Africa
July 9-12th, 2014We are in the midst of planning the next International Society for Serotonin Research meeting to be held July 9-12, 2014 at the Arabella Hotel and Spa in South Africa (http://www.africanpridehotels.com/hotels/Pages/arabella-hotel-spa.aspx). Arabella is a beautiful estate located about an hour (60 miles, 100km) from Cape Town International Airport (CPT).
“Arabella Hotel & Spa rests in the heart of the Kogelberg Biosphere Reserve. Hugged by the Rooisands Nature Reserve, the Bot River Lagoon and Kogelberg Mountains, every room leads to a private terrace or balcony overlooking pristine grounds, swimming pool, mountain views or lagoon waters. The hotel offers a variety of elegant restaurants and bars to indulge even the most discerning palate with fine cuisine and wine. Leisure facilities include a heated indoor hydro pool, sauna, and an award-winning spa. Beyond the walls of this five-star retreat, you’re spoilt for choice with activities, such as kayaking at sea, horseback rides through the shore and golf at the prestigious Arabella Golf Course, to name a few.”
The local organizing committee (LOC), composed of Professor Brian Harvey (chair), Professor Sandra van Dyk, Mr. De Wet Wolmaran, Professor Soraya Seedat, Dr. Sian Hemmings and Mr. Jacques Joubert, is doing a fantastic job. The meeting will be comprised of 15 symposia in a single session format (see listing below), a full session devoted to our Young Investigators (NIDA Travel Awardees- i.e., graduate students, post-doctoral fellows and early-stage investigators) and an evening poster session. In addition, we are very pleased to announce that the honorary Irvine Page plenary lecture will be given by Professor Herbert Meltzer (Northwestern University, USA) and the honorary Maurice Rapport plenary lecture will given by Professor Charles Marsden (University of Nottingham, UK). In addition to the Gala dinner, the LOC is in the process of planning some wonderful evening social events, including the opening reception and a wine tasting. The opening reception will be the evening of Wednesday, July 9, with full day sessions July 10, 11 and 12. To close the meeting, the Gala dinner will be held the evening
of Saturday, July 12. The 2014 meeting website is currently under construction and we plan to have travel, hotel and touring information available by the end of October, 2013. We expect that meeting registration and abstract submission for poster presentations to “go live” in early January, 2014. In the interim, please see our Society website (http://www.serotoninclub.org) for updates.
Continued on page 75...The Congress venue offers an African ambience
with the feel of open space in the interior.
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“A Serotonin Safari”: July 9-12, Arabella, South Africa
“Serotonin neurons come of age with 5-HT1A receptor function”
Chair: Dr. Sheryl Beck, Univ Pennsylvania, USA; Co-Chair: Dr. Evan Deneris, Case Western Reserve, USASpeakers: Dr. Sheryl Beck, Dr. Evan Deneris and Dr. Rodrigo Andrade
(Wayne State Univ, USA)
“From Optogenetics to the Microbiome: Emerging strategies to understand the role of 5-HT in anxiety and addiction”Chair: Dr. Andrew Holmes, NIAAA, NIH, USASpeakers: Dr. Andrew Holmes, Dr. Nicolas Singewald (Univ Innsbruck,
Austria), and Prof. John Cryan (Univ College Cork, Ireland).
“Cell-type dissection of the serotoninergic system and of its developmental targets”
Chair: Dr. Alexandre Dayer, University of Geneva, SwitzerlandSpeakers: Dr. Alexandre Dayer, Dr. Philippe Marin (Univ Montpellier, France)
and Dr. Patricia Gaspar (Institut du Fer a Moulin, INSERM, Univ Paris, France).
“Fast Measurements of Serotonin in Brain - Implications for Psychiatric Disease and Drug Abuse”
Chair: Dr. Lynette Daws, Univ Texas Health Science Center San Antonio, USA; Co-Chair: Dr. Anne Andrews, UCLA, USASpeakers: Dr. Lynette Daws, Dr. Katie Ann Jennings (Oxford, UK) and Dr
Parastoo Hashemi (Wayne State Univ, USA)
“Serotonin: a new hope in Alzheimer’s disease?”
Chair: Dr. Sylvie Claeysen, Montpellier University, France; Co-Chair: Prof. Joel Bockaert, Montpellier University, FranceSpeakers: Dr. Sylvie Claeysen, Dr. Christophe Arbus (Toulouse Univ,
France) and Dr. John Cirrito (Washington Univ, USA).
“Serotonin and schizophrenia”
Chair: Dr. Maarten van den Buuse, Univ Melbourne, Australia; Co-Chair: Dr. Herb Meltzer, Northwestern Univ, USASpeakers: Prof. Kevin Fone (Univ Nottingham Medical School, UK), Dr.
Maarten van den Buuse and Dr. Mark Geyer (UCSD, USA)
“The 5-HT2C receptor at the interface of obesity and addiction”
Chair: Dr. Harriët Schellekens, Univ College Cork, Ireland; Co-Chair: Prof. John F. Cryan, Univ College Cork, IrelandSpeakers: Dr. Lora Heisler (Cambridge Univ, UK), Dr. Guy Higgins (Univ
Toronto, Canada) and Dr. Harriët Schellekens
“Novel insights into serotonin receptor structure and function”
Chair: Prof. Finn Olav Levy, Univ Oslo, NorwaySpeakers: Prof. Joel Bockaert (Univ Montpellier, France), Dr. Kjetil
Andressen (Univ Oslo,Norway) and Mr. Daniel Wacker (Scripps Research Institute, USA)
“Serotonylation: regulation in diverse systems from tetrahymena to mammalian brain”
Chair: Dr. Nancy Muma, Univ Kansas, USASpeakers: Dr. Nancy Muma, Dr. Diego Walther (Max Planck Institute,
Germany) and Dr. Patrick Schoss (Zentralinstitut für Seelische Gesundheit, Germany)
“Drug addiction and impulsivity: is serotonin involved?”
Chair: Dr. Athina Markou, UCSD, USA; Co-Chair: Dr. Kathryn Cunningham, Univ Texas Med Branch, USASpeakers: Dr. Kathryn Cunningham, Dr. Athina Markou and Dr. Trevor Robbins (Cambridge Univ, UK)
“Serotonin, a modulator of innate immune cells”
Chair: Dr. Luc Maroteaux, Institut du Fer a Moulin, INSERM, Univ Paris, FranceSpeakers: Dr. Angel Corbi (Consejo Superior de Investigaciones Cientifica,
Spain) Professor Josef Priller (Charite Univ, Germany) and Dr. Anne Roumier (Institut du Fer a Moulin, INSERM, Univ Paris, France)
“5-HT receptors: from function to structure and back”
Chair: Prof. Dan Hoyer, Univ Melbourne, Australia;Co-Chair: Prof. Nicholas Barnes, Univ Birmingham, UK
Speakers: Prof. Dan Hoyer, Prof. Sarah Lumis (Univ Cambrige, UK) and Dr. John McCorvy (UNC-Chapel Hill, USA)
“New contributions of serotonin receptors and their molecular networks in synaptogenesis, degeneration and addiction”Chair: Prof. Valérie Compan, Univ Montpellier, France
Speakers: Dr. Evgeni Ponimaskin (Medical School Hanover, Germany), Dr. Veronique Sgambato-Faure (CNRS, France) and Dr. Valerie Compan
“The role of serotonin systems in the adverse neuropsychiatric side effects and recreational use of HIV-1 antiretroviral drugs”Chair: Dr. John Schetz, Univ North Texas Health Science Center, USACo-Chair: Dr. Charles France, Univ Texas Health Science Center San Antonio, USASpeakers: Dr. John Schetz, Dr. Javier González-Maeso (Mount Sinai
School of Medicine, USA) and Dr. Charles France“Serotonin, cortical microcircuitry and cognition”Chair: Prof. Trevor Sharp, Oxford, UK; Co-Chair: Dr. Connie Sanchez-Morillo, Lundbeck Research, USASpeakers: Dr. Guadalupe Mengod (Barcelona, Spain), Dr. Victoria Puig (MIT, USA) and Dr. Judith Homberg (Nijmegen, The Netherlands).
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The International Symposium on Methods for Studying Drug Metabolism and Transport and Herbal Derived Medicines (Methods 2014) will be held in Cape Town, South Africa, from 10 to 11 July 2014. It is a satellite symposium to the 17th World Congress of Basic and Clinical Pharmacology (WCP2014) which will begin later in the week. More details can be obtained at the symposium website: www.methods2014.org.
This will be an exciting moment during which world-renowned experts will share their experiences in a collegial atmosphere with the overall aim of building capacity through skills transfer. With the help of a well-constituted International Scientific Committee, the Methods 2014 Organising Committee has assembled an outstanding programme featuring internationally recognised experts who are at the forefront of their respective research areas.
We recognise that “Methods” are the driver for research and drug discovery. With advancing technology, the scientific methods are changing at a faster rate and this calls for frequent reappraisal. Therefore, under the theme “Rallying for Quality, Safe and Effective Medicines”, the symposium will introduce this scientific gathering to new developments in the relevant scientific research methods used to study drug metabolism and transport, and in the development of herbal derived medicines.
We are excited not only because this is the first event of its kind in Africa, but also because so many world experts have accepted our invitations to share their expertise on our soil. Furthermore, this gives us an opportunity to celebrate the success of efforts by organisations such as the IUPHAR section on Drug Metabolism and Transport, the International Society for the Study of Xenobiotics (ISSX), and the African Institute of Biomedical Science and Technology (AiBST) in promoting drug metabolism research in the region. Specifically, the African Society for Drug Metabolism and Development (ASDMD, www.asdmd.org) was formed through such efforts.
A warm welcome and an exhilarating social programme await you, and the people of South Africa and the host city of Cape Town anticipate your arrival. We hope that this will be a memorable meeting and we look forward to welcoming you to Cape Town.
Prof Andrew Walubo
Symposium CHAIR
INVITATIONMETHODS 2014
INTERNATIONAL SYMPOSIUM ON METHODS FOR STUDYING DRUG METABOLISM AND TRANSPORT AND HERBAL DERIVED MEDICINES
10 - 11 JULY 2014
ASDMD (www.asdmd.org)THE AFRICAN SOCIETY FOR DRUG METABOLISM AND DEVELOPMENT
“Striving for Drug Efficacy, Safety and Availability”
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Methods 2014 Symposium SecretariatAfrican AgendaTel: +27 (0)21 683 2934 Email: [email protected]
NH THE LORD CHARLES HOTELCorner Main Road (M9) and Broadway Boulevard (R44) Somerset West, 7130, Cape Town, South AfricaTel (021) 855 1040 Fax: (021) 855 [email protected]
NH The Lord Charles Hotel is a luxurious 4-star hotel in Somerset West that offers 197 comfortable and well-equipped, air-conditioned guestrooms. It also offers internet by wireless or dial-up access and currency exchange facility.
• Registrationopens August 2013
• Submissionsiteopens August 2013
• Deadlineforsubmissions 28 February 2014
• Notificationofacceptance March 2014
• Endofearlyregistrationdiscount 15 May 2014
• Methods2014 10-11 July 2014
IMPORTANT DATES
PROVIS IONAL PROGRAMME
www.methods2014.org
VENUE AND ACCOMMODATION
REGISTRATION INFORMATION
REGISTRATION FEES
StandardDelegateRegistrationFee(before15May2014) ZAR 2,750.00
LateDelegateRegistrationFee(after15May2014) ZAR 3,250.00
Delegate Registration Includes• Access to all Symposium sessions Thursday - Friday• TeabreaksandlunchesonallSymposiumdays• Methods 2014 documentation
Excludes• Accommodation costs• Travel costs• Travel insurance
CALL FOR POSTERSSUBMISSION OF POSTER INFORMATION Participants are welcome to submit original research-related abstracts for poster presentations only. Oral abstracts will be from the invited speakers. Abstracts are subject to peer-review for quality research, scientific content and logical presentation. The deadline for submission of abstracts is 28 February 2014.
Authors chosen for a poster session will be given at least a full day to display their poster. Posters will be displayed in the foyer of the symposium venue, where refreshments will be served. During poster sessions, the authors of the posters will be required to be available for discussion of their work.
ABSTRACT SPECIFICATIONSAbstracts must contain 4 sections:
a. OBJECTIVE: introductory sentence indicating the objective and purpose of the study.
b METHODS: description of experimental procedures, including applicable statistical evaluation.
c. RESULTS: summary of the data and results.
d. CONCLUSIONS: statement of the study’s conclusions.• Abstracts should be written in English.• Abstract title should be given in UPPER CASE. The title should define the topic and contain no
abbreviations.• In the body of the abstract, standard abbreviations need not be defined; other abbreviations and
acronyms should be defined on first use.• Generic names for pharmaceuticals, biologics and medical devices should be used in place of trade
names. Trade names should only be used if equivalent products from multiple manufacturers are being compared.
• Capitalise all trade names.• Italicise scientific names.• Overly commercial abstracts will not be accepted.• Do not include graphics, photographs or tables.• Maximum word count for the body of the abstract is 250 words (2000 characters).• Submissions may have up to six authors. The lead author’s name should appear first and will be the
author that is corresponded with.• The institutional and professional affiliations of all authors will be required.
SUBMISSION INSTRUCTIONS• Prepare your abstract to the above specifications.
• Access the submission site via the symposium website: www.methods2014.org
SYMPOSIUM WEBSITEwww.methods2014.org
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79www.iuphar-ed2014.org
Join us for the IUPHAR-Ed Pharmacology Education Satellite Meeting in
Cape Town (South Africa) - 12 & 13 July 2014
Key topics to be covered include:
• Flipped lectures• Students as agents of change• Faculty development• Novel assessment solu<ons• Inter-‐professional educa<on• Pharmacology educa<on in Africa• Internet-‐based educa<on solu<ons
Share your experience and research with us in a relaxed and informal atmosphere! Apply for Early Educator Awards in
Basic, Clinical and Trans-‐disciplinary Pharmacology.
For more informa<on and registra<on details visit our website at www.iuphar-ed2014.org
Organised by: An official satellite meeting of:
Are you passionate
about education
in Pharmacology?
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The 17th World Congress of Basic and
Clinical Pharmacology (WCP 2014) is now
only months out, and registration and
abstract submissions opened in August 2013.
WCP2014 is overwhelmed with global support,
including interest from eminent groups to hold
satellite meetings, and special interest to support
participation by African pharmacologists and
more. Of note is that the young pharmacologists of
the British Pharmacology Society have been selling
T - shirts to support African Pharmacologists to attend
WCP 2014.
Now we all look forward to the first ever IUPHAR
World Congress on the African continent in Cape
Town. The mother city of South Africa, is a world-
class city that beats to the pulse of Africa - a place
where service and world class meeting facilities
converge with excellent infrastructure and support
systems – the ideal location for hosting IUPHAR in
2014. And do not forget the destination, the tours,
the safaris, and the warm-hearted people. Cape
Town has unparalleled natural wonders, set on a
peninsula of rocky heights, lush valleys and oceans.
Table Mountain, named one of the New 7 Wonders
of Nature in 2012, a plethora of pristine beaches
and famed Cape flora are only minutes away from
the Cape Town International Convention Centre
(CTICC), the venue of WCP 2014. “Pharmacology
at the cutting-edge” will combine basic and clinical
as well as translational pharmacology, addressing
the health care challenges of our world as the
theme of the 17th World Congress from the 13-18
July 2014.
The exceptional scientific programme, along with
satellite meetings and training of next generation
scientists, will bring world renowned speakers
and delegates to Africa, deliberating medicines,
diseases and therapeutics of critical importance
such as oncology, immunology HIV/AIDS and
other infectious diseases, diseases of lifestyle,
pharmacology of the brain, regulatory and
translational pharmacology and cutting-edge
discoveries in pharmacology.
We started down this road some time ago and have
travelled the continents of our world with a vision
to unite the pharmacologists across the globe.
We look forward to welcoming you in Cape Town.
Vanessa Steenkamp
Chair: Marketing Committee
We now invite you to share your pharmacology with us and to enjoy
a truly African and South African experience in Cape Town.
REGISTER NOW for WCP2014 in Cape Town
December 2013
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March
European College of Neuropsychopharmacology Workshop for Junior Scientists in Europe March 6 - 9, 2014 in Nice, Francehttp://www.ecnp.eu/meetings/workshops.aspx
Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics March 19 - 22, 2014 in Atlanta, Georga, USAhttp://www.ascpt.org/Meetings/FutureAnnualMeetings/tabid/6705/Default.aspx
53rd Annual Meeting and ToxExpo by Society of Toxicology March 23 - 27, 2014 in Phoenix, Arizona, USAhttp://www.toxicology.org/ai/meet/am.asp
April
80th Annual Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology April 1 - 4, 2014 in Hanover, Germanyhttp://dgpt-online.de/startseite.html
Spring Meeting of the Swiss Society for Pharmacology and Toxicology on “Pharmacology and Toxicology in Times of Change” April 3, 2014 in Bern, Switzerlandhttp://www.swisspharmtox.ch/events.html
Proactive Pharmacovigilance and Risk Management in the Era of Personalised Medicine sponsored by the International Society of Pharmacovigilance April 3 - 4, 2014 in Zagreb, Croatiahttp://www.isoponline.org/index.php?page=training
Upcoming Events Upcoming Events
Continued on page 83...
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Upcoming Events Upcoming EventsApril (continued)
European College of Neuropsychopharmacology School of Child and Adolescent Neuropsychopharmacology April 6 - 11, 2014 in Venice, Italyhttp://www.ecnp.eu/meetings/ecnp-school.aspx
P2T: the 9th Congress of Physiology, Pharmacology and Therapeutics by the French Society of Pharmacology and Therapeutics April 22 - 24, 2014 in Poitiers, Francehttp://congres-p2t.fr
Experimental Biology ‘14, sponsored by the American Society for Pharmacology and Experimental Therapeutics April 26 - 30, 2014 in San Diego, California, USAhttp://www.aspet.org/Meetings.aspx?id=426
5th British Pharmacological Society Focused Meeting on Cell Signaling April 28 - 29, 2014 in Leicester, United Kingdomhttp://www.bps.ac.uk/meetings/139a131cf49
June
Canadian Society of Pharmacology and Therapeutics Annual Meeting June 10 - 13, 2014 in Winnipeg, Manitoba, Canadahttp://www.pharmacologycanada.org/events
European College of Neuropsychopharmacology School of Neuropsychopharmacology June 29 - July 4, 2014 in Oxford, United Kingdomhttp://www.ecnp.eu/meetings/ecnp-school.aspx
To include your events here, please e-mail the details to [email protected] .
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Pharmacology InternationalPublished June and December
Editor-in-Chief Managing Editor Dr. S.J. Enna, Secretary-General Ms. Lynn LeCount, Admin. Officer
Editorial BoardThe IUPHAR Executive Committee serves as the Editorial Board.
Published by IUPHAR Administrative Office University of Kansas Medical Center 3901 Rainbow Blvd. Mail Stop #4016 Kansas City, Kansas 66160 USA Tel: 1.913.588.7533 Fax: 1.913.588.7373 [email protected] www.iuphar.org
Contributions:We welcome contributions from member societies, divisions, sections and committees. Please submit articles and photographs to [email protected] at least one month prior to the cover date.
Membership:The members of IUPHAR are national, international, and special research interest societies. If you are an individual, please visit www.iuphar.org for additional information on the societies you may be interested in joining.
ISSN 1462-9941© 2013 IUPHARAll Rights Reserved
Dr. Enna’s office L→R: Lynn LeCount, Jennifer McNichols, S. J. Enna and Leigh Ann Arbuckle
Clinical Division Representatives
Chair Vice Chair
Secretary General
Treasurer
Donald J. Birkett, Australia
Darrell Abernethy, USA
Petra Thürmann, Germany
María Isabel Lucena, Spain
2010-2014 IUPHAR Executive Committee
Councilors
Patrick du Souich, Canada
President 1st VicePresident
2nd VicePresident
SecretaryGeneral
Treasurer
Graeme Henderson, UK
Masamitsu Iino, Japan
S. J. Enna, USA
Urs Ruegg, Switzerland
Kim Brøsen, Denmark
Kay Brune,Germany
John Miners,Australia
Douglas Oliver, South Africa
Yongxiang Zhang, PR China
Past President
Sue Piper Duckles, USA
December 2013