8/15/2019 Pharmacology exam advice

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PHCL 4001 Exam Study Tips (Lecture #16 material)

Become familiar with the equations used to calculate:

Therapeutic Index (TI)

Certain Safety FactorTotal Body Clearance (assuming elimination follows 1st order kinetics)

Steady State Concentration in the plasma

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The following practice question is an example of the sort that MIGHT  be asked on theexam, based on material covered in Lecture #16 (March 22, 2016).

1. A healthy volunteer ( Joe Smith  ) is given an experimental drug in a Phase 1clinical trial.  A 300 mg dose with 80% oral bioavailability is administered every12 hours for 7 days. Analysis on the 4 th   day indicates a steady state plasmaconcentration of 10 mg/L is achieved in this volunteer. 

A. Based on these data, calculate the Joe Smith!s Total Clearance for this drug.

A second healthy volunteer ( John Doe  ) in the Phase 1 clinical trial, following anidentical protocol, achieves a steady state plasma concentration of 20 mg/L.

B. Provide one of many possible reasons why the steady state concentration forJohn Doe is two times greater than that for the volunteer Joe Smith.