PERSONAL INFORMATION Olaf Klungel INFORMATION Olaf Klungel ... European Journal of Clinical Pharmacology, 72 (9), ... Pharmacoepidemiology and Drug Safety, 25

Curriculum vitae

PERSONAL INFORMATION Olaf Klungel

WORK EXPERIENCE

September 1994–September1998

PhD studentUniversiteit Utrecht (Netherlands)

Pharmacoepidemiological research

September 1998–December1999

PostdocUniversiteit Utrecht (Netherlands)

Postdoc researcher at University of Washington, Seattle (US)

December 1999–August 2003 Assistant professorUniversiteit Utrecht (Netherlands)

Pharmacoepidemiological research and teaching

August 2003–December 2014 Associate professorUniversiteit Utrecht (Netherlands)


January 2015–Present Full professor, Head of divisionUniversiteit Utrecht (Netherlands)


EDUCATION AND TRAINING

August 1987–October 1992 Pharmacy (doctoraal)Rijks Universiteit Groningen (Netherlands)

Pharmacy

October 1992–May 1994 PharmD (postdoctoral)Rijks Universiteit Groningen (Netherlands)

Pharmacist

March 1999–June 2003 MSc Epidemiology + PhD EpidemiologyUniversiteit Utrecht (Netherlands)

ADDITIONAL INFORMATION

Expertise Olaf Klungel is Professor of Pharmacoepidemiologic Methods at the division of Pharmacoepidemiology & Clinical Pharmacology. He was trained as a pharmacist and epidemiologist.His main research area is the development, improvement and evaluation of innovative methods of observational drug research. Main applications are in the post-registration phase of drug development. Selected research findings on benefits and harms of medicines include the impact of genetic variants in the renin-angiotensin and salt-sensitivity system on the risk of type 2 diabetes mellitus and myocardial infarction associated with the use of thiazide diuretics and ACE inhibitors, the discovery that thiazide diuretics have a particular beneficial effect compared to other antihypertensive drugs in the prevention of the risk of ischemic stroke (research performed at University of Washington

6/9/17 © European Union, 2002-2017 | http://europass.cedefop.europa.eu Page 1 / 25

Curriculum vitae Olaf Klungel

in Seattle, US in collaboration with Prof. Bruce Psaty). More recent findings include the increased risk of autoimmune diseases such as rheumatoid arthritis and lupus-like syndrome associated with the use of statins and increased bleeding risk with concurrent use of selective serotonin inhibitors and coumarins. In addition to his research, Prof. Klungel teaches pharmacoepidemiology and pharmacotherapy to medical and pharmacy students. He is (co-)author of over 200 papers in peer reviewed journals, book chapters and research reports.

Publications 2016 - Scholarly publications

Afonso, A., Schmiedl, S., Becker, C., Tcherny-Lessenot, S., Primatesta, P., Plana, E., Souverein, P., Wang, Y., Korevaar, J.C., Hasford, J., Reynolds, R., de Groot, M.C.H., Schlienger, R., Klungel, O. & Rottenkolber, M. (2016). A methodological comparison of two European primary care databases and replication in a US claims database: inhaled long-acting beta-2-agonists and the risk of acute myocardial infarction. European Journal of Clinical Pharmacology, 72 (9), (pp. 1105–1116) (12 p.).

Schmidt, Amand F, Klungel, Olaf H, Groenwold, Rolf H H & , (2016). Adjusting for Confounding in Early Postlaunch Settings - Going Beyond Logistic Regression Models. Epidemiology, 27 (1), (pp. 133-42) (10 p.).

Ali, M Sanni, Groenwold, Rolf Hh & Klungel, Olaf H (2016). Best (but oft-forgotten) practices - propensity score methods in clinical nutrition research. American Journal of Clinical Nutrition, 104 (2), (pp. 247-58) (12 p.). © 2016 American Society for Nutrition..

Grimaldi-Bensouda, Lamiae, Klungel, Olaf, Kurz, Xavier, de Groot, Mark C H, Maciel Afonso, Ana S, de Bruin, Marie L, Reynolds, Robert & Rossignol, Michel (2016). Calcium channel blockers and cancer - a risk analysis using the UK Clinical Practice Research Datalink (CPRD). BMJ Open, 6 (1). Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

De Groot, Mark C. H., Candore, Gianmario, Uddin, Md. Jamal, Souverein, Patrick, Ali, M. Sanni, Belitser, S., Huerta, Consuelo, Groenwold, Rolf H. H., Alvarez, Yolanda, Slattery, Jim, Korevaar, Joke, Hoes, Arno W., Roes, Kit C. B., de Boer, Anthonius, Douglas, Ian J., Schlienger, Raymond G., Reynolds, Robert, Klungel, Olaf H. & Gardarsdottir, Helga (01.03.2016). Case-only designs for studying the association of antidepressants and hip or femur fracture. Pharmacoepidemiology and Drug Safety, 25 (Supplement S1), (pp. 103-113) (11 p.).

Schmidt, A F, Nielen, M, Withrow, S J, Selmic, L E, Burton, J H, Klungel, O H, Groenwold, R H H & Kirpensteijn, J (01.03.2016). Chemotherapy effectiveness and mortality prediction in surgically treated osteosarcoma dogs - A validation study. Preventive Veterinary Medicine, 125, (pp. 126-134). Copyright © 2016 Elsevier B.V. All rights reserved..

Wong, Dennis R, Coenen, Marieke J H, Vermeulen, Sita H, Derijks, Luc J J, van Marrewijk, Corine J, Klungel, Olaf H, Scheffer, Hans, Franke, Barbara, Guchelaar, Henk-Jan, de Jong, Dirk J, Engels, Leopold G J B, Verbeek, André L M & Hooymans, Piet M (09.07.2016). Early Assessment of Thiopurine Metabolites Identifies Patients at Risk of Thiopurine-Induced Leukopenia in Inflammatory Bowel Disease. Journal of Crohn's and Colitis, (pp. 1-10) (10 p.). Copyright © 2016 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: [email protected]..

Uddin, Md Jamal, Groenwold, Rolf H H, de Boer, Anthonius, Afonso, Ana S M, Primatesta, Paola, Becker, Claudia, Belitser, S., Hoes, Arno W., Roes, Kit C B & Klungel, Olaf H. (01.03.2016). Evaluating different physician's prescribing preference based instrumental variables in two primary care databases - A study of inhaled long-acting beta2-agonist use and the risk of myocardial infarction.Pharmacoepidemiology and Drug Safety, 25 (Supplement 1), (pp. 132-141) (10 p.).

Klungel, Olaf H. (22.01.2016). Farmaco-epidemiologie - Let op methodologische valkuilen. Pharmaceutisch Weekblad, 151 (3), (pp. 14-16) (3 p.).

Schuerch, Markus, Gasse, Christiane, Robinson, Noah Jamie, Alvarez, Yolanda, Walls, Robert, Mors, Ole, Christensen, Jakob, Hesse, Ulrik, de Groot, Mark, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf & de Vries, Frank (2016). Impact of varying outcomes and definitions of suicidality on theassociations of antiepileptic drugs and suicidality - comparisons from UK Clinical Practice Research Datalink (CPRD) and Danish national registries (DNR). Pharmacoepidemiology and Drug Safety, 25 Suppl 1, (pp. 142-55) (14 p.). Copyright © 2016 John Wiley & Sons, Ltd..

Uddin, Md Jamal, Groenwold, Rolf H H, de Boer, Anthonius, Gardarsdottir, Helga, Martin, Elisa, Candore, Gianmario, Belitser, Svetlana V., Hoes, Arno W., Roes, Kit C B & Klungel, Olaf H. (01.03.2016). Instrumental variables analysis using multiple databases - An example of antidepressant use and risk of hip fracture. Pharmacoepidemiology and Drug Safety, 25 (Supplement S1), (pp. 122-131) (10 p.).

Ali, M Sanni, Groenwold, Rolf H H, Belitser, S., Souverein, Patrick C, Martín, Elisa, Gatto, Nicolle M,



Huerta, Consuelo, Gardarsdottir, Helga, Roes, Kit C B, Hoes, Arno W, de Boer, Anthonius & Klungel, Olaf H (2016). Methodological comparison of marginal structural model, time-varying Cox regression, and propensity score methods - the example of antidepressant use and the risk of hip fracture. Pharmacoepidemiology and Drug Safety, 25 (Suppl 1), (pp. 114-121) (8 p.). Copyright © 2016 John Wiley & Sons, Ltd..

Uddin, Md Jamal, Groenwold, Rolf H H, Ali, Mohammed Sanni, de Boer, Anthonius, Roes, Kit C B, Chowdhury, Muhammad A B & Klungel, Olaf H. (18.04.2016). Methods to control for unmeasured confounding in pharmacoepidemiology - an overview. International Journal of Clinical Pharmacy, 38 (3), (pp. 714-723) (10 p.).

Klungel, Olaf H., Kurz, Xavier, de Groot, Mark C. H., Schlienger, Raymond G., Tcherny-Lessenot, Stephanie, Grimaldi, Lamiae, Ibáñez, Luisa, Groenwold, Rolf H. H., Reynolds, Robert F., Alvarez, Y., Candore, G., Durand, J., Slattery, J., Hasford, J., Rottenkolber, M., Schmiedl, S., de Abajo Iglesias, F., Gil, M., Gonzalez, R., Huerta Alvarez, C., Martin, E., Oliva, B., Requena, G., Amelio, J., Brauer, R., Downey, G., Feudjo-Tepie, M., Schoonen, M., Johansson, S., Robinson, J., Schuerch, M., Tatt, I., Petri, H., Garcia, L.A., Ruigomez, A., Campbell, J., Gallagher, A., Ng, E., van Staa, T.P., Demol, O., Boudiaf, N., Davis, K., Logie, J., Pimenta, J., Beau-Lejdstrom, R., Grimaldi-Bensouda, L., Abenhaim, L., Grimaldi-Bensouda, L., Rossignol, M., Hesse, U., Rønn, P.F., Miret, M., Fortuny, J., Primatesta, P., Rivero, E., Schlienger, R., Bate, A., Gatto, N., Ballarin, E., Ferrer, P., Ibañez, L., Laporte, J.R., Sabaté, M., Abbing-Karahagopian, V., Ali, S., de Bakker, D., Belitser, S., de Boer, Anthonius, De Bruin, M.L., Egberts, A.C.G., van Dijk, L., Gardarsdottir, H., Hoes, A.W., Leufkens, H.G.M., Pestman, W., Roes, K.C.B., Souverein, P., Rutten, F., Uddin, J., van den Ham, H.A., Voogd, E., de Vries, Frank, De Bruin, M.L., Udo, R., Auclert, L., Juhaeri, J., Mazuranok, L., Wise, L., Irvine, D., Dolin, P., Gasse, C. & , (01.03.2016). Multi-centre, multi-database studies with common protocols: Lessons learnt from the IMIPROTECT project. Pharmacoepidemiology and Drug Safety, 25 (supplement S1), (pp. 156-165) (10 p.).

Wing, Kevin, Bhaskaran, Krishnan, Smeeth, Liam, van Staa, Tjeerd P, Klungel, Olaf H, Reynolds, Robert F & Douglas, Ian (2016). Optimising case detection within UK electronic health records - use ofmultiple linked databases for detecting liver injury. BMJ Open, 6 (9), (pp. 1-12) (12 p.). Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence)please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

Yasmina, Alfi, de Boer, Anthonius, Deneer, Vera H M, Souverein, Patrick C & Klungel, Olaf H (23.09.2016). Patterns of antiplatelet drug use after a first myocardial infarction during a 10-years period. British Journal of Clinical Pharmacology This article is protected by copyright. All rights reserved..

Makady, A.A.M.A., ten Ham, R.M.T., de Boer, A., Hillige, H, Klungel, O.H. & Goettsch, W.G. (2016). Policies for use of Real-World Data in Health Technology Assessment: A comparative study of 6 HTA agencies. Value in Health

Brauer, Ruth, Douglas, Ian, Garcia Rodriguez, Luis Alberto, Downey, Gerald, Huerta, Consuelo, de Abajo, Francisco, Bate, Andrew, Feudjo Tepie, Maurille, de Groot, Mark C H, Schlienger, Raymond, Reynolds, Robert, Smeeth, Liam, Klungel, Olaf & Ruigómez, Ana (01.03.2016). Risk of acute liver injury associated with use of antibiotics. Comparative cohort and nested case-control studies using two primary care databases in Europe. Pharmacoepidemiology and Drug Safety, 25 (Supplement S1),(pp. 29-38) (10 p.).

Schmidt, A. F., Klungel, O. H., Nielen, M., de Boer, A., Groenwold, R. H H & Hoes, A. W. (15.02.2016).Tailoring treatments using treatment effect modification. Pharmacoepidemiology and Drug Safety, 25 (4), (pp. 355-362) (8 p.).

Reynolds, Robert F, Kurz, Xavier, de Groot, Mark C H, Schlienger, Raymond G, Grimaldi-Bensouda, Lamiae, Tcherny-Lessenot, Stephanie & Klungel, Olaf H (2016). The IMI PROTECT project - purpose,organizational structure, and procedures. Pharmacoepidemiology and Drug Safety, 25 Suppl 1, (pp. 5-10) (6 p.). Copyright © 2016 John Wiley & Sons, Ltd..

Souverein, Patrick C, Abbing-Karahagopian, Victoria, Martin, Elisa, Huerta, Consuelo, de Abajo, Francisco, Leufkens, Hubert G M, Candore, Gianmario, Alvarez, Yolanda, Slattery, Jim, Miret, Montserrat, Requena, Gema, Gil, Miguel J, Groenwold, Rolf H H, Reynolds, Robert, Schlienger, Raymond G, Logie, John W, de Groot, Mark C H, Klungel, Olaf H, van Staa, Tjeerd P, Egberts, Toine C G, De Bruin, Marie L & Gardarsdottir, Helga (2016). Understanding inconsistency in the results fromobservational pharmacoepidemiological studies - the case of antidepressant use and risk of hip/femur fractures. Pharmacoepidemiology and Drug Safety, 25 (Suppl 1), (pp. 88-102) (15 p.). Copyright © 2016 John Wiley & Sons, Ltd..

2015 - Scholarly publications

Uddin, Jamal, Groenwold, Rolf H.H., Ali, M. Sanni, Candore, Gianmario, De Groot, Mark C.H., Souverein, Patrick C., Alvarez, Yolanda, Belitser, S., Hoes, Arno W., De Boer, Anthonius, Roes, Kit



C.B., Klungel, Olaf H. & Gardarsdottir, Helga (01.08.2015). Application of the self-controlled case series design in pharmacoepidemiological studies: A cautionary note. European Journal of Epidemiology, 30 (8), (pp. 903) (1 p.).

Broekman, Mark M., Coenen, Marieke J., Franke, Barbara, Derijks, Luc J., Vermeulen, Sita H., Wong,Dennis R., Klungel, Olaf H., Verbeek, Andre L., Hooymans, Piet, Scheffer, Hans, Guchelaar, Henk-Jan, Van Marrewijk, Corine J. & De Jong, Dirk J. (01.04.2015). Azathioprine and 6-mercaptopurine areequally effective in thiopurine naïve IBD patients. Gastroenterology, 148 (4), (pp. 269) (1 p.).

van den Ham, Hendrika A, Klungel, Olaf H, Singer, Daniel E, Leufkens, Hubert G M & van Staa, Tjeerd P (2015). Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc Risk Scores Predicting Stroke in Patients With Atrial Fibrillation - Results From a National Primary Care Database. Journal of the American College of Cardiology, 66 (17), (pp. 1851-9) (9 p.). Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved..

Ali, Sanni, Groenwold, Rolf H.H., Belitser, S., Roes, Kit C.B., Hoes, Arno W., De Boer, Anthonius & Klungel, Olaf H. (01.09.2015). Covariate balance assessment, model selection and bias in propensity score matching: A simulation study. Pharmacoepidemiology and Drug Safety, 24, (pp. 22) (1 p.).

Requena, Gema, Logie, John, Martin, Elisa, Boudiaf, Nada, González González, Rocío, Huerta, Consuelo, Alvarez, Arturo, Webb, David, Bate, Andrew, García Rodríguez, Luis A., Reynolds, Robert, Schlienger, Raymond, Gardarsdottir, Helga, de Groot, Mark, Klungel, Olaf H., de Abajo, Fancisco & Douglas, Ian J. (04.10.2015). Do case-only designs yield consistent results across design and different databases? A case study of hip fractures and benzodiazepines. Pharmacoepidemiology and Drug Safety

Huerta, Consuelo, Abbing-Karahagopian, Victoria, Requena, Gema, Oliva, Belén, Alvarez, Yolanda, Gardarsdottir, Helga, Miret, Montserrat, Schneider, Cornelia, Gil, Miguel, Souverein, Patrick C, De Bruin, Marie L, Slattery, Jim, De Groot, Mark C H, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, Montero, Dolores, Bate, Andrew, Ruigomez, Ana, García-Rodríguez, Luis Alberto, Johansson, Saga, de Vries, Frank, Schlienger, Raymond G, Reynolds, Robert F, Klungel, Olaf H & de Abajo, Francisco José (07.07.2015). Exposure to benzodiazepines (anxiolytics, hypnotics and related drugs) in seven European electronic healthcare databases - a cross-national descriptive study from the PROTECT-EU Project. Pharmacoepidemiology and Drug Safety

Requena, Gema, Huerta, Consuelo, Gardarsdottir, Helga, Logie, John, González-González, Rocío, Abbing-Karahagopian, Victoria, Miret, Montserrat, Schneider, Cornelia, Souverein, Patrick C, Webb, Dave, Afonso, Ana, Boudiaf, Nada, Martin, Elisa, Oliva, Belén, Alvarez, Arturo, De Groot, Mark C H, Bate, Andrew, Johansson, Saga, Schlienger, Raymond, Reynolds, Robert, Klungel, Olaf H & de Abajo, Francisco J (23.06.2015). Hip/femur fractures associated with the use of benzodiazepines (anxiolytics, hypnotics and related drugs) - a methodological approach to assess consistencies acrossdatabases from the PROTECT-EU project. Pharmacoepidemiology and Drug Safety

Coenen, Marieke J H, de Jong, Dirk J, van Marrewijk, Corine J, Derijks, Luc J J, Vermeulen, Sita H, Wong, Dennis R, Klungel, Olaf H, Verbeek, Andre L M, Hooymans, Piet M, Peters, Wilbert H M, te Morsche, Rene H M, Newman, William G, Scheffer, Hans, Guchelaar, Henk-Jan, Franke, Barbara & , (2015). Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease. Gastroenterology, 149 (4), (pp. 907-17.e7). Copyright © 2015 AGA Institute. Published by Elsevier Inc. All rights reserved..

Uddin, Md. Jamal, Groenwold, Rolf H.H., Ali, Mohammed Sanni, Candore, Gianmario, De Groot, Mark C.H., Souverein, Patrick C., Alvarez, Yolanda, Belitser, S., Hoes, Arno W., De Boer, Anthonius, Roes, Kit C.B., Klungel, Olaf & Gardarsdottir, Helga (01.09.2015). Impact of violations of the assumptions of the self-controlled case series design in pharmacoepidemiological studies: An example of antidepressants use and the risk of hip fracture. Pharmacoepidemiology and Drug Safety, 24, (pp. 2-3) (2 p.).

Sabaté, Mònica, Ferrer, Pili, Ballarín, Elena, Rottenkolber, Marietta, Amelio, Justyne, Schmiedl, Sven, Reynolds, Robert, Klungel, Olaf, Ibáñez, Luisa, , & de Vries, Frank (2015). Inpatient drug utilization in Europe - nationwide data sources and a review of publications on a selected group of medicines (PROTECT project). Basic and Clinical Pharmacology and Toxicology, 116 (3), (pp. 201-211) (11 p.). ©2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society)..

Hazelbag, Christijan M, Klungel, Olaf H, van Staa, Tjeerd P, de Boer, Anthonius & Groenwold, Rolf H H (2015). Left truncation results in substantial bias of the relation between time-dependent exposures and adverse events. International Journal of Epidemiology, 25 (8), (pp. 590-6) (7 p.). Copyright © 2015Elsevier Inc. All rights reserved..

Ferrer, P., Sabaté, M., Ballarín, E., Rottenkolber, M., Schmiedl, S., Amelio, J., De Abajo, F., Ruigómez,A., Gil, M., Huerta, C., Gardarsdottir, H., Afonso, A., Klungel, O., De Groot, M., Schlinger, R., Reynolds, R. & Ibáñez, L. (01.08.2015). Measuring drug use: Differences between medical records and healthcare utilisation data bases. Clinical Therapeutics, 37 (8), (pp. 75) (1 p.).



Yasmina, Alfi, De Boer, Anthonius, Klungel, Olaf H. & Souverein, Patrick C. (01.09.2015). Patterns of antiplatelet use in patients with myocardial infarction and subsequent acute coronary syndrome events. Pharmacoepidemiology and Drug Safety, 24, (pp. 119) (1 p.).

Uddin, Md Jamal, Groenwold, Rolf H H, van Staa, Tjeerd P, de Boer, Anthonius, Belitser, Svetlana V, Hoes, Arno W, Roes, Kit C B & Klungel, Olaf H (01.05.2015). Performance of prior event rate ratio adjustment method in pharmacoepidemiology - a simulation study. Pharmacoepidemiology and Drug Safety, 24 (5), (pp. 468-477) (10 p.). Copyright © 2014 John Wiley & Sons, Ltd..

Brauer, Ruth, Ruigómez, Ana, Downey, Gerry, Bate, Andrew, Garcia Rodriguez, Luis Alberto, Huerta, Consuelo, Gil, Miguel, de Abajo, Francisco, Requena, Gema, Alvarez, Yolanda, Slattery, Jim, de Groot, Mark, Souverein, Patrick, Hesse, Ulrik, Rottenkolber, Marietta, Schmiedl, Sven, de Vries, Frank, Tepie, Maurille Feudjo, Schlienger, Raymond, Smeeth, Liam, Douglas, Ian, Reynolds, Robert &Klungel, Olaf (07.07.2015). Prevalence of antibiotic use - a comparison across various European health care data sources. Pharmacoepidemiology and Drug Safety

Ng, Edmond S-W, Klungel, Olaf H, Groenwold, Rolf H H & van Staa, Tjeerd-Pieter (01.07.2015). Risk patterns in drug safety study using relative times by accelerated failure time models when proportionalhazards assumption is questionable - an illustrative case study of cancer risk of patients on glucose-lowering therapies. Pharmaceutical Statistics, 14 (5), (pp. 382-94) (13 p.). Copyright © 2015 John Wiley & Sons, Ltd..

Rañopa, Michael, Douglas, Ian, van Staa, Tjeerd, Smeeth, Liam, Klungel, Olaf, Reynolds, Robert & Bhaskaran, Krishnan (2015). The identification of incident cancers in UK primary care databases - a systematic review. Pharmacoepidemiology and Drug Safety, 24, (pp. 11-18) (8 p.). Copyright © 2014 John Wiley & Sons, Ltd..

Brauer, Ruth, Ruigómez, Ana, Klungel, Olaf, Reynolds, Robert, Feudjo Tepie, Maurille, Smeeth, Liam & Douglas, Ian (06.08.2015). The risk of acute liver injury among users of antibiotic medications - a comparison of case-only studies. Pharmacoepidemiology and Drug Safety © 2015 The Authors Pharmacoepidemiology and Drug Safety Published by John Wiley & Sons Ltd..

Alharbi, Fawaz F., Souverein, Patrick C., De Groot, Mark C.H., Der Zee, Anke H Maitland-Van, De Boer, Anthonius & Klungel, Olaf H. (01.09.2015). The risk of acute myocardial infarction after discontinuation of antihypertensive agents. Pharmacoepidemiology and Drug Safety, 24, (pp. 199-200) (2 p.).

Rottenkolber, Marietta, Voogd, Eef, van Dijk, Liset, Primatesta, Paola, Becker, Claudia, Schlienger, Raymond, de Groot, Mark C H, Alvarez, Yolanda, Durand, Julie, Slattery, Jim, Afonso, Ana, Requena, Gema, Gil, Miguel, Alvarez, Arturo, Hesse, Ulrik, Gerlach, Roman, Hasford, Joerg, Fischer, Rainald, Klungel, Olaf H & Schmiedl, Sven (23.02.2015). Time trends of period prevalence rates of patients with inhaled long-acting beta-2-agonists-containing prescriptions - a European comparative database study. PLoS One, 10 (2).

Groenwold, Rolf H H, de Groot, Mark C H, Ramamoorthy, Dhivya, Souverein, Patrick C & Klungel, Olaf H (07.11.2015). Unmeasured confounding in pharmacoepidemiology. International Journal of Epidemiology, (pp. 85-86).

Alharbi, Fawaz F., Souverein, Patrick C., Blom, Marieke T., Tan, Hanno L., De Boer, Anthonius & Klungel, Olaf H. (01.09.2015). Use of antihypertensive agents and the risk of out-of-hospital cardiac arrest: A case control study. Pharmacoepidemiology and Drug Safety, 24, (pp. 200) (1 p.).

Schmidt, A F, Groenwold, R H H, Amsellem, P, Bacon, N, Klungel, O H, Hoes, A W, de Boer, Anthonius, Kow, K, Maritato, K, Kirpensteijn, J & Nielen, M (17.12.2015). Which dogs with appendicular osteosarcoma benefit most from chemotherapy after surgery? Results from an individualpatient data meta-analysis. Preventive Veterinary Medicine (10 p.). Copyright © 2015 Elsevier B.V. All rights reserved..


Abbing-Karahagopian, V., Huerta, C., Souverein, P.C., De Abajo, F., Leufkens, H.G.M., Slattery, J., Alvarez, Y., Miret, M., Gil, M., Oliva, B., Hesse, U., Requena, G., De Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlienger, R.G., De Groot, M.C.H., Klungel, O.H., Van Staa, T.P., Van Dijk, L., Egberts, A.C.G., Gardarsdottir, H. & De Bruin, M.L. (01.04.2014). Antidepressant prescribing in five European countries: Application of common definitions to assess the prevalence, clinical observations, and methodological implications. European Journal of Clinical Pharmacology, 70 (7), (pp. 849-857) (9 p.).

Ali, MSanni, De Groot, Mark, Candore, Giammario, Groenwold, Rolf H.H., Souverein, Patrick C., Alvarez, Yolanda, Uddin, Md J., Hoes, Arno W., De Boer, A., Klungel, Olaf H. & Gardarsdottir, Helga (01.10.2014). Antidepressantuse and the risk of hip fracture: A self-controlled case series approach in two primary care databases. Pharmacoepidemiology and Drug Safety, 23, (pp. 385) (1 p.).

de Groot, Mark C H, Schuerch, Markus, de Vries, Frank, Hesse, Ulrik, Oliva, Belén, Gil, Miguel,



Huerta, Consuelo, Requena, Gema, de Abajo, Francisco, Afonso, Ana S, Souverein, Patrick C, Alvarez, Yolanda, Slattery, Jim, Rottenkolber, Marietta, Schmiedl, Sven, Van Dijk, Liset, Schlienger, Raymond G, Reynolds, Robert & Klungel, Olaf H (2014). Antiepileptic drug use in seven electronic health record databases in Europe - a methodologic comparison. Epilepsia, 55 (5), (pp. 666-673) (8 p.).

Yasmina, A, Deneer, V H M, Maitland-van der Zee, A H, van Staa, T P, de Boer, A & Klungel, O H (2014). Application of routine electronic health record databases for pharmacogenetic research. Journal of Internal Medicine, 275 (6), (pp. 590-604) (15 p.). © 2014 The Association for the Publicationof the Journal of Internal Medicine..

Ruigómez, A., Brauer, R., Rodríguez, L. A García, Huerta, C., Requena, G., Gil, M., de Abajo, Francisco, Downey, G., Bate, A., Tepie, M. Feudjo, de Groot, M.C.H., Schlienger, R., Reynolds, R. & Klungel, O. (29.07.2014). Ascertainment of acute liver injury in two European primary care databases. European Journal of Clinical Pharmacology, 70 (10), (pp. 1227-1235) (9 p.).

Holmes, Michael V., Dale, Caroline E., Zuccolo, Luisa, Silverwood, Richard J., Guo, Yiran, Ye, Zheng, Prieto-Merino, David, Dehghan, Abbas, Trompet, Stella, Wong, Andrew, Cavadino, Alana, Drogan, Dagmar, Padmanabhan, Sandosh, Li, Shanshan, Yesupriya, Ajay, Leusink, Maarten, Sundstrom, Johan, Hubacek, Jaroslav A., Pikhart, Hynek, Swerdlow, Daniel I., Panayiotou, Andrie G., Borinskaya,Svetlana A., Finan, Chris, Shah, Sonia, Kuchenbaecker, Karoline B., Shah, Tina, Engmann, Jorgen, Folkersen, Lasse, Eriksson, Per, Ricceri, Fulvio, Melander, Olle, Sacerdote, Carlotta, Gamble, Dale M., Rayaprolu, Sruti, Ross, Owen A., McLachlan, Stela, Vikhireva, Olga, Sluijs, Ivonne, Scott, Robert A., Adamkova, Vera, Flicker, Leon, Van Bockxmeer, Frank M., Power, Christine, Marques-Vidal, Pedro, Meade, Tom, Marmot, Michael G., Ferro, Jose M., Paulos-Pinheiro, Sofia, Humphries, Steve E., Talmud, Philippa J., Leach, Irene Mateo, Verweij, Niek, Linneberg, Allan, Skaaby, Tea, Doevendans, Pieter A., Cramer, Maarten J., Van Der Harst, Pim, Klungel, Olaf H., Dowling, Nicole F., Dominiczak, Anna F., Kumari, Meena, Nicolaides, Andrew N., Weikert, Cornelia, Boeing, Heiner, Ebrahim, Shah, Gaunt, Tom R., Price, Jackie F., Lannfelt, Lars, Peasey, Anne, Kubinova, Ruzena, Pajak, Andrzej, Malyutina, Sofia, Voevoda, Mikhail I., Tamosiunas, Abdonas, Maitland-van Der Zee, Anke H., Norman, Paul E., Hankey, Graeme J., Bergmann, Manuela M., Hofman, Albert, Franco, Oscar H., Cooper, Jackie, Palmen, Jutta, Spiering, Wilko, De Jong, Pim A., Kuh, Diana, Hardy, Rebecca, Uitterlinden, Andre G., Ikram, M. Arfan, Ford, Ian, Hyppönen, Elina, Almeida, Osvaldo P., Wareham, Nicholas J., Khaw, Kay Tee, Hamsten, Anders, Husemoen, Lise Lotte N, Tjønneland, Anne, Tolstrup, Janne S., Rimm, Eric, Beulens, Joline W J, Verschuren, W. M Monique, Onland-Moret, N. Charlotte, Hofker, Marten H., Wannamethee, S. Goya, Whincup, Peter H., Morris, Richard, Vicente, Astrid M., Watkins, Hugh, Farrall, Martin, Jukema, J. Wouter, Meschia, James, Cupples, L. Adrienne, Sharp, Stephen J., Fornage, Myriam, Kooperberg, Charles, LaCroix, Andrea Z., Dai, JamesY., Lanktree, Matthew B., Siscovick, David S., Jorgenson, Eric, Spring, Bonnie, Coresh, Josef, Li, Yun R., Buxbaum, Sarah G., Schreiner, Pamela J., Ellison, R. Curtis, Tsai, Michael Y., Patel, Sanjay R., Redline, Susan, Johnson, Andrew D., Hoogeveen, Ron C., Hakonarson, Hakon, Rotter, Jerome I., Boerwinkle, Eric, De Bakker, Paul I W, Kivimaki, Mika, Asselbergs, Folkert W., Sattar, Naveed, Lawlor,Debbie A., Whittaker, John, Smith, George Davey, Mukamal, Kenneth, Psaty, Bruce M., Wilson, James G., Lange, Leslie A., Hamidovic, Ajna, Nordestgaard, Børge G., Bobak, Martin, Leon, David A.,Langenberg, Claudia, Palmer, Tom M., Reiner, Alex P., Keating, Brendan J., Dudbridge, Frank & Casas, Juan P. (10.07.2014). Association between alcohol and cardiovascular disease - Mendelian randomisation analysis based on individual participant data. British Medical Journal, 349 (16 p.).

Schmidt, Amand F, Klugkist, Irene, Klungel, Olaf H, Nielen, Mirjam, de Boer, Anthonius, Hoes, Arno W& Groenwold, Rolf H H (28.11.2014). Bayesian methods including nonrandomized study data increased the efficiency of postlaunch RCTs. Journal of Clinical Epidemiology, 68 (4), (pp. 387-396) (10 p.). Copyright © 2015 Elsevier Inc. All rights reserved..

Abbing-Karahagopian, Victoria, Kurz, Xavier, de Vries, Frank, van Staa, Tjeerd P, Alvarez, Yolanda, Hesse, Ulrik, Hasford, Joerg, Dijk, Liset van, de Abajo, Francisco J, Weil, John G, Grimaldi-Bensouda,Lamiae, Egberts, Antoine C G, Reynolds, Robert F & Klungel, Olaf H (2014). Bridging differences in outcomes of pharmacoepidemiological studies - design and first results of the PROTECT project. Current Clinical Pharmacology, 9 (2), (pp. 130-138) (9 p.).

Leusink, M., Onland-Moret, N. C., Asselbergs, F. W., Ding, B., Kotti, S., Van Zuydam, N. R., Papp, A. C., Danchin, N., Donnelly, L., Morris, A. D., Chasman, D. I., Doevendans, P. A F M, Klungel, O. H., Ridker, P. M., Van Gilst, W. H., Simon, T., Nyberg, F., Palmer, C. N A, Sadee, W., Van Der Harst, P., DeBakker, P. I W, De Boer, A., Verstuyft, C. & Maitland-Van Der Zee, A. H. (01.03.2014). Cholesteryl ester transfer protein polymorphisms, statin use, and their impact on cholesterol levels and cardiovascular events. Clinical Pharmacology and Therapeutics, 95 (3), (pp. 314-320) (7 p.).

Fournier, J.P., Duijnhoven, R.G., Renoux, C., Dell'Aniello, S., Klungel, O.H. & Suissa, S. (2014). Concurrent use of statins and hormone therapy and risk of venous thromboembolism in postmenopausal women: a population-based case-control study. Menopause, 21 (9).



Wing, Kevin, Douglas, Ian, Bhaskaran, Krishnan, Klungel, Olaf H, Reynolds, Robert F, Pirmohamed, Munir, Smeeth, Liam & van Staa, Tjeerd P (2014). Development of predictive genetic tests for improving the safety of new medicines - the utilization of routinely collected electronic health records. Drug Discovery Today, 19 (4), (pp. 361-6) (6 p.). Copyright © 2013 Elsevier Ltd. All rights reserved..

Prieto-Alhambra, D., Petri, H., Goldenberg, J. S B, Khong, T. P., Klungel, O. H., Robinson, N. J. & De Vries, F. (01.03.2014). Excess risk of hip fractures attributable to the use of antidepressants in five European countries and the USA. Osteoporosis International, 25 (3), (pp. 847-855) (9 p.).

Schmidt, Amand F., Groenwold, Rolf H.H., Knol, Mirjam J., Hoes, Arno W., Nielen, Mirjam, Roes, Kit C.B., De Boer, Anthonius & Klungel, Olaf H. (01.07.2014). Exploring interaction effects in small samples increases rates of false-positive and false-negative findings: Results from a systematic review and simulation study. Journal of Clinical Epidemiology, 67 (7), (pp. 821-829) (9 p.).

Swerdlow, Daniel I, Preiss, David, Kuchenbaecker, Karoline B, Holmes, Michael V, Engmann, Jorgen E L, Shah, Tina, Sofat, Reecha, Stender, Stefan, Johnson, Paul C D, Scott, Robert A, Leusink, Maarten, Verweij, Niek, Sharp, Stephen J, Guo, Yiran, Giambartolomei, Claudia, Chung, Christina, Peasey, Anne, Amuzu, Antoinette, Li, KaWah, Palmen, Jutta, Howard, Philip, Cooper, Jackie A, Drenos, Fotios, Li, Yun R, Lowe, Gordon, Gallacher, John, Stewart, Marlene C W, Tzoulaki, Ioanna, Buxbaum, Sarah G, van der A, Daphne L, Forouhi, Nita G, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Schnabel, Renate B, Hubacek, Jaroslav A, Kubinova, Ruzena, Baceviciene, Migle, Tamosiunas, Abdonas, Pajak, Andrzej, Topor-Madry, Romanvan, Stepaniak, Urszula, Malyutina, Sofia, Baldassarre, Damiano, Sennblad, Bengt, Tremoli, Elena, de Faire, Ulf, Veglia, Fabrizio, Ford, Ian, Jukema, J Wouter, Westendorp, Rudi G J, de Borst, Gert Jan, de Jong, Pim A, Algra, Ale, Spiering, Wilko, der Zee, Anke H Maitland-van, Klungel, Olaf H, de Boer, Anthonius, Doevendans, Pieter A, Eaton, Charles B, Robinson, Jennifer G, Duggan, David, Kjekshus, John, Downs, John R, Gotto, Antonio M, Keech, Anthony C, Marchioli, Roberto, Tognoni, Gianni, Sever, Peter S, Poulter, Neil R, Waters, David D, Pedersen, Terje R, Amarenco, Pierre, Nakamura, Haruo, McMurray, John J V, Lewsey, James D, Chasman, Daniel I, Ridker, Paul M, Maggioni, Aldo P, Tavazzi,Luigi, Ray, Kausik K, Seshasai, Sreenivasa Rao Kondapally, Manson, JoAnn E, Price, Jackie F, Whincup, Peter H, Morris, Richard W, Lawlor, Debbie A, Smith, George Davey, Ben-Shlomo, Yoav, Schreiner, Pamela J, Fornage, Myriam, Siscovick, David S, Cushman, Mary, Kumari, Meena, Wareham, Nick J, Verschuren, W M Monique, Redline, Susan, Patel, Sanjay R, Whittaker, John C, Hamsten, Anders, Delaney, Joseph A, Dale, Caroline, Gaunt, Tom R, Wong, Andrew, Kuh, Diana, Hardy, Rebecca, Kathiresan, Sekar, Castillo, Berta A, van der Harst, Pim, Brunner, Eric J, Tybjaerg-Hansen, Anne, Marmot, Michael G, Krauss, Ronald M, Tsai, Michael, Coresh, Josef, Hoogeveen, Ronald C, Psaty, Bruce M, Lange, Leslie A, Hakonarson, Hakon, Dudbridge, Frank, Humphries, Steve E, Talmud, Philippa J, Kivimäki, Mika, Timpson, Nicholas J, Langenberg, Claudia, Asselbergs, Folkert W, Voevoda, Mikhail, Bobak, Martin, Pikhart, Hynek, Wilson, James G, Reiner, Alex P, Keating,Brendan J, Hingorani, Aroon D, Sattar, Naveed & , (24.09.2014). HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight - evidence from genetic analysis and randomised trials. The Lancet Copyright © 2014 Swerdlow et al. Open Access article distributed under the terms of CC BY. Published by Elsevier Ltd. All rights reserved..

Requena, G., Abbing-Karahagopian, V., Huerta, C., De Bruin, M.L., Alvarez, Y., Miret, M., Hesse, U., Gardarsdottir, H., Souverein, P.C., Slattery, J., Schneider, C., Rottenkolber, M., Schmiedl, S., Gil, M., De Groot, M.C.H., Bate, A., Ruigómez, A., García Rodríguez, L.A., Johansson, S., De Vries, F., Montero, D., Schlienger, R., Reynolds, R., Klungel, O.H. & De Abajo, F.J. (01.06.2014). Incidence rates and trends of hip/femur fractures in five European countries: Comparison using e-healthcare records databases. Calcified Tissue International, 94 (6), (pp. 580-589) (10 p.).

Schmidt, Amand F., Groenwold, Rolf H H, Van Delden, Johannes J M, Van Der Does, Yuri, Klungel, Olaf H., Roes, Kit C B, Hoes, Arno W. & Van Der Graaf, Rieke (01.01.2014). Justification of exclusion criteria was underreported in a review of cardiovascular trials. Journal of Clinical Epidemiology, 67 (6), (pp. 635-644) (10 p.).

Schmiedl, S., Fischer, R., Ibáñez, L., Fortuny, J., Klungel, O., Reynolds, R., Gerlach, R., Tauscher, M., Thuermann, P., Hasford, J. & Rottenkolber, M. (01.07.2014). Long-acting beta-2-adrenoceptor agonists and anticholinergic drugs: Drug utilisation and off-label use in paediatric patients living in Bavaria (Germany). Basic and Clinical Pharmacology and Toxicology, 115, (pp. 74) (1 p.).

Uddin, Md. Jamal, Groenwold, Rolf H. H., de Boer, Anthonius, Belitser, Svetlana V., Roes, Kit C. B., Hoes, Arno W. & Klungel, Olaf H. (2014). Performance of instrumental variable methods in cohort andnested case-control studies: A simulation study. Pharmacoepidemiology and Drug Safety, 23 (2), (pp. 165-177) (13 p.).

Coenen, M., Van Marrewijk, C., Derijks, L., Vermeulen, S., Wong, D., Klungel, O., Verbeek, A., Hooymans, P., Scheffer, H., Guchelaar, H.-J., Franke, B. & De Jong, D. (01.02.2014). Personalized thiopurine dosing based on TPMT genotyping reduces leucopenia occurrence and results in cost-savings in IBD patients. Results from a randomized trial in the Netherlands. Journal of Crohn's and



Colitis, 8, (pp. 4) (1 p.).

Yasmina Noorsyahdy, Alfi, de Boer, Anthonius, Klungel, Olaf H & Deneer, Vera H M (2014). Pharmacogenomics of oral antiplatelet drugs. Pharmacogenomics, 15 (4), (pp. 509-28) (20 p.).

Ali, M. Sanni, Groenwold, Rolf H H, Pestman, Wiebe R., Belitser, Svetlana V., Roes, Kit C B, Hoes, Arno W., de Boer, Anthonius & Klungel, Olaf H. (2014). Propensity score balance measures in pharmacoepidemiology: A simulation study. Pharmacoepidemiology and Drug Safety, 23 (8), (pp. 802-811) (10 p.).

Ali, M. Sanni, Groenwold, Rolf H H & Klungel, Olaf H. (01.01.2014). Propensity score methods and unobserved covariate imbalance - Comments on "squeezing the balloon". Health Services Research, 49 (3), (pp. 1074-1082) (9 p.).

de Groot, Mark C H, Klungel, Olaf H., Leufkens, Hubert G M, van Dijk, Liset, Grobbee, Diederick E. & van de Garde, Ewoudt M W (15.10.2014). Sources of heterogeneity in case–control studies on associations between statins, ACE-inhibitors, and proton pump inhibitors and risk of pneumonia. European Journal of Epidemiology, 29 (10), (pp. 767-775) (9 p.).

de Keyser, C.E., Peters, B.J.M., Becker, M.L., Visser, L.E., Uitterlinden, A.G., Klungel, O.H., Verstuyft, C., Hofman, A., Maitlan d-van der Zee, A.H. & Stricker, B.H.Ch (2014). The SLCO1B1 c.521T>C polymorphism is associated with dose decrease or switching during statin therapy in the Rotterdam Study. Pharmacogenetics and Genomics, 24 (1), (pp. 43-51) (9 p.).

Van Staa, T.-P., Klungel, O. & Smeeth, L. (2014). Use of electronic healthcare records in large-scale simple randomized trials at the point of care for the documentation of value-based medicine. Journal of Internal Medicine, 275 (6), (pp. 562-569) (8 p.).

Schmiedl, Sven, Fischer, Rainald, Ibáñez, Luisa, Fortuny, Joan, Klungel, Olaf H., Reynolds, Robert, Gerlach, Roman, Tauscher, Martin, Thürmann, Petra, Hasford, Joerg & Rottenkolber, Marietta (14.01.2014). Utilisation and off-label prescriptions of respiratory drugs in children. PLoS One, 9 (9).


Van Der Baan, F.H., Knol, M.J., Maitland-Van Der Zee, A.H., Regieli, J.J., Van Iperen, E.P.A., Egberts, A.C.G., Klungel, O.H., Grobbee, D.E. & Jukema, J.W. (01.08.2013). Added value of pharmacogenetic testing in predicting statin response: Results from the REGRESS trial. Pharmacogenomics Journal, 13 (4), (pp. 318-324) (7 p.).

Groenwold, Rolf H H, Klungel, Olaf H, Altman, Douglas G, van der Graaf, Yolanda, Hoes, Arno W, Moons, Karel G M, , & van Staa, Tjeerd (2013). Adjustment for continuous confounders - an example of how to prevent residual confounding. CMAJ, 185 (5), (pp. 401-406) (6 p.).

Abbing-Karahagopian, V., Huerta, C., Souverein, P.C., De Abajo, F., Leufkens, H.G.M., Slattery, J., Alvarez, Y., Montserrat, M., Gil, M., Hesse, U., Requena, G., De Vries, F., Rottenkolber, M., Schmiedl, S., Reynolds, R., Schlinger, R., De Groot, M.C.H., Klungel, O.H., Van Staa, T.P., Van Dijk, L., Egberts, A.C.G., Gardarsdottir, H. & De Bruin, M.L. (01.10.2013). Antidepressant prescribing in five european countries: Application of common methods to assess the variation in prevalence. Pharmacoepidemiology and Drug Safety, 22, (pp. 279-280) (2 p.).

Schmidt, Amand F., Groenwold, Rolf H.H., Pocock, Stuart, Gueyffier, Francois, Hoes, Arno W., De Boer, Anthonius, Nielen, Mirjam & Klungel, Olaf H. (01.10.2013). Comparing effectiveness estimates from randomized and nonrandomized studies, using subgroup analyses and individual patient data. Pharmacoepidemiology and Drug Safety, 22, (pp. 29-30) (2 p.).

Schmidt, Amand F., Rovers, Maroeska M., Klungel, Olaf H., Hoes, Arno W., Knol, Mirjam J., Nielen, Mirjam, De Boer, Antonius & Groenwold, Rolf H.H. (01.06.2013). Differences in interaction and subgroup-specific effects were observed between randomized and nonrandomized studies in three empirical examples. Journal of Clinical Epidemiology, 66 (6), (pp. 599-607) (9 p.).

Wangge, Grace, de Boer, Anthonius, Klungel, Olaf H, Hoes, Arno W & Knol, Mirjam J (2013). Expert-opinion on non-inferiority margin - a case study of oral anti-coagulant agents for prophylaxis of venousthromboembolic events after orthopedic surgery. Thrombosis Research, 131 (4), (pp. 368-71) (4 p.).

Wangge, G., de Boer, A., Klungel, O.H., Hoes, A.W. & Knol, M.J. (2013). Expert-opinion on non-inferiority margin: a case study of oral anti-coagulant agents for prophylaxis of venous thromboembolicevents after orthopedic surgery. Thrombosis Research, 131 (4), (pp. 368-71) (4 p.).

Boessen, R., van der Baan, F.H., Groenwold, R.H.H., Egberts, A.C.G., Klungel, O.H., Grobbee, D.E., Knol, M.J. & Roes, K.C.B. (2013). Optimizing trial design in pharmacogenetics research: comparing a fixed parallel group, group sequential, and adaptive selection design on sample size requirements. Pharmaceutical Statistics, 12, (pp. 366-374) (9 p.).

Bernabe, Rosemarie D L C, Wangge, Grace, Knol, Mirjam J, Klungel, Olaf H, van Delden, Johannes JM, de Boer, Anthonius, Hoes, Arno W, Raaijmakers, Jan A M & van Thiel, Ghislaine J M W (01.01.2013). Phase IV non-inferiority trials and additional claims of benefit. BMC Medical Research



Methodology, 13, (pp. 70) (1 p.).

Schmidt, A.F., Nielen, M., Klungel, O.H., Hoes, A.W., de Boer, A., Groenwold, R.H.H., Kirpensteijn, J. & , (01.11.2013). Prognostic factors of early metastasis and mortality in dogs with appendicular osteosarcoma after receiving surgery - an individual patient data meta-analysis. Preventive Veterinary Medicine, 112 (3-4), (pp. 414-422) (9 p.). Copyright © 2013 Elsevier B.V. All rights reserved..

Uddin, M. Jamal, Ali, M. Sanni, Groenwold, Rolf H.H., Pestman, W.R., Belitser, Svetlana V., Hoes, Arno W., De Boer, Anthonius, Roes, Kit C.B. & Klungel, Olaf H. (15.06.2013). Quantitative verification of instrumental variables assumption using balance measures. American Journal of Epidemiology, 177, (pp. 102) (1 p.).

Wangge, Grace, Putzeist, Michelle, Knol, Mirjam J., Klungel, Olaf H., Gispen-De Wied, Christine C., de Boer, Antonius, Hoes, Arno W., Leufkens, Hubert G. & Mantel-Teeuwisse, Aukje K. (05.09.2013). Regulatory Scientific Advice on Non-Inferiority Drug Trials. PLoS One, 8 (9).

Donnelly, Louise A., Van Zuydam, Natalie R., Zhou, Kaixin, Tavendale, Roger, Carr, Fiona, Maitland-Van Der Zee, Anke H., Leusink, Maarten, De Boer, Anthonius, Doevendans, Pieter A., Asselbergs, Folkert W., Morris, Andrew D., Pearson, Ewan R., Klungel, Olaf H., Doney, Alex S.F. & Palmer, Colin N.A. (01.10.2013). Robust association of the LPA locus with low-density lipoprotein cholesterol lowering response to statin treatment in a meta-analysis of 30 467 individuals from both randomized control trials and observational studies and association with coronary artery disease outcome during statin treatment. Pharmacogenetics and Genomics, 23 (10), (pp. 518-525) (8 p.).

Holmes, Michael V., Simon, Tabassome, Exeter, Holly J., Folkersen, Lasse, Asselbergs, Folkert W., Guardiola, Montse, Cooper, Jackie A., Palmen, Jutta, Hubacek, Jaroslav A., Carruthers, Kathryn F., Horne, Benjamin D., Brunisholz, Kimberly D., Mega, Jessica L., Van Iperen, Erik P.A., Li, Mingyao, Leusink, Maarten, Trompet, Stella, Verschuren, Jeffrey J.W., Hovingh, G. Kees, Dehghan, Abbas, Nelson, Christopher P., Kotti, Salma, Danchin, Nicolas, Scholz, Markus, Haase, Christiane L., Rothenbacher, Dietrich, Swerdlow, Daniel I., Kuchenbaecker, Karoline B., Staines-Urias, Eleonora, Goel, Anuj, Van 'T Hooft, Ferdinand, Gertow, Karl, De Faire, Ulf, Panayiotou, Andrie G., Tremoli, Elena, Baldassarre, Damiano, Veglia, Fabrizio, Holdt, Lesca M., Beutner, Frank, Gansevoort, Ron T., Navis, Gerjan J., Mateo Leach, Irene, Breitling, Lutz P., Brenner, Hermann, Thiery, Joachim, Dallmeier,Dhayana, Franco-Cereceda, Anders, Boer, Jolanda M.A., Stephens, Jeffrey W., Hofker, Marten H., Tedgui, Alain, Hofman, Albert, Uitterlinden, André G., Adamkova, Vera, Pitha, Jan, Onland-Moret, N. Charlotte, Cramer, Maarten J., Nathoe, Hendrik M., Spiering, Wilko, Klungel, Olaf H., Kumari, Meena, Whincup, Peter H., Morrow, David A., Braund, Peter S., Hall, Alistair S., Olsson, Anders G., Doevendans, Pieter A., Trip, Mieke D., Tobin, Martin D., Hamsten, Anders, Watkins, Hugh, Koenig, Wolfgang, Nicolaides, Andrew N., Teupser, Daniel, Day, Ian N.M., Carlquist, John F., Gaunt, Tom R., Ford, Ian, Sattar, Naveed, Tsimikas, Sotirios, Schwartz, Gregory G., Lawlor, Debbie A., Morris, Richard W., Sandhu, Manjinder S., Poledne, Rudolf, Maitland-Van Der Zee, Anke H., Khaw, Kay-Tee, Keating, Brendan J., Van Der Harst, Pim, Price, Jackie F., Mehta, Shamir R., Yusuf, Salim, Witteman, Jaqueline C.M., Franco, Oscar H., Jukema, J. Wouter, De Knijff, Peter, Tybjaerg-Hansen, Anne, Rader, Daniel J., Farrall, Martin, Samani, Nilesh J., Kivimaki, Mika, Fox, Keith A.A., Humphries, Steve E., Anderson, Jeffrey L., Boekholdt, S. Matthijs, Palmer, Tom M., Eriksson, Per, Paré, Guillaume, Hingorani, Aroon D., Sabatine, Marc S., Mallat, Ziad, Casas, Juan P. & Talmud, Philippa J. (2013). Secretory phospholipase A2-IIA and cardiovascular disease: A mendelian randomization study. Journal of the American College of Cardiology, 62 (21), (pp. 1966-1976) (11 p.).

de Jong, H.J.I., Damoiseaux, J.G., Vandebriel, R.J., Souverein, P.C., Gremmer, E.R., Wolfs, M., Klungel, O.H., van Loveren, H., Cohen Tervaert, J.W. & Verschuren, W.M. (2013). Statin use and markers of immunity in the doetinchem cohort study. PLoS One, 8 (10) (1 p.).

van den Ham, H.A., Klungel, O.H., Leufkens, H.G.M. & van Staa, T.P. (2013). The patterns of anticoagulation control and the risk of stroke, bleeding and mortality in patients with non-valvular atrial fibrillation. Journal of Thrombosis and Haemostasis, 11 (1), (pp. 107-15) (9 p.).

Ali, M.S., Groenwold, R.H.H., Pestman, W.R., Belitser, S.V., Hoes, A.W., de Boer, A. & Klungel, O.H. (2013). Time-dependent propensity score and collider-stratification bias: an example of beta(2)-agonist use and the risk of coronary heart disease. European Journal of Epidemiology, 28 (4), (pp. 291-299) (9 p.).


de Jong, H.J.I., Vandebriel, R.J., Saldi, S.R.F., van Dijk, L., van Loveren, H., Cohen Tervaert, J.W. & Klungel, O.H. (2012). Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers andrisk of developing rheumatoid arthritis in antihypertensive drug users. Pharmacoepidemiology and Drug Safety, 21, (pp. 835-843) (9 p.).

de Jong, Hilda J.I., Vandebriel, Rob J., Saldi, Siti R.F., van Dijk, Liset, van Loveren, Henk, Cohen Tervaert, Jan Willem & Klungel, Olaf H. (01.08.2012). Angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers and the risk of developing rheumatoid arthritis in antihypertensive drug



users. Pharmacoepidemiology and Drug Safety, 21 (8), (pp. 835-843) (9 p.).

van Vliet-Ostaptchouk, Jana V, van Haeften, Timon W, Landman, Gijs W D, Reiling, Erwin, Kleefstra, Nanne, Bilo, Henk J G, Klungel, Olaf H, de Boer, Anthonius, van Diemen, Cleo C, Wijmenga, Cisca, Boezen, H Marike, Dekker, Jacqueline M, van 't Riet, Esther, Nijpels, Giel, Welschen, Laura M C, Zavrelova, Hata, Bruin, Elinda J, Elbers, Clara C, Bauer, Florianne, Onland-Moret, N Charlotte, van der Schouw, Yvonne T, Grobbee, Diederick E, Spijkerman, Annemieke M W, van der A, Daphne L, Simonis-Bik, Annemarie M, Eekhoff, Elisabeth M W, Diamant, Michaela, Kramer, Mark H H, Boomsma, Dorret I, de Geus, Eco J, Willemsen, Gonneke, Slagboom, P Eline, Hofker, Marten H & 't Hart, Leen M (2012). Common variants in the type 2 diabetes KCNQ1 gene are associated with impairments in insulin secretion during hyperglycaemic glucose clamp. PLoS One, 7 (3), (pp. e32148).

Eussen, Simone R.B.M., Geleijnse, Johanna M., Giltay, Erik J., Rompelberg, Cathy J.M., Klungel, OlafH. & Kromhout, Daan (13.07.2012). Effects of n-3 fatty acids on major cardiovascular events in statin users and non-users with a history of myocardial infarction. European Heart Journal, 33 (13), (pp. 1582-1588) (7 p.).

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Khong, T P, de Vries, F, Goldenberg, J S B, Klungel, O H, Robinson, N J, Ibáñez, Luisa & Petri, H (2012). Potential impact of benzodiazepine use on the rate of hip fractures in five large European countries and the United States. Calcified Tissue International, 91 (1), (pp. 24-31) (8 p.).

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de Jong, Hilda J. I., Saldi, Siti R. F., Klungel, Olaf H., Vandebriel, Rob J., Souverein, Patrick C., Meyboom, Ronald H. B., Passier, J.L.M., van Loveren, Henk & Tervaert, Jan Willem Cohen (23.07.2012). Statin-associated polymyalgia rheumatica. An analysis using WHO global individual case safety database: A case/non-case approach. PLoS One, 7 (7), (pp. e41289) (1 p.).

Vandebriel, R.J., de Jong, H.J.I., Gremmer, E.R., Klungel, O.H., Tervaert, J.W., Slob, W., van der Laan, J.W. & van Loveren, H. (2012). Statins accelerate the onset of collagen type II-induced arthritis in mice. Arthritis Research and Therapy, 14 (2), (pp. R90) (1 p.).

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de Jong, H.J.I., Klungel, O.H., van Dijk, L., Vandebriel, R.J., Leufkens, H.G.M., van der Laan, J.W., Cohen Tervaert, J.W. & van Loveren, H. (2012). Use of statins is associated with an increased risk of rheumatoid arthritis. Annals of the Rheumatic Diseases, 71 (5), (pp. 648-54) (7 p.).


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de Jong, Hilda J.I., Cohen Tervaert, Jan Willem, Saldi, Siti R.F., Vandebriel, Rob J., Souverein, Patrick C., Meyboom, Ronald H.B., van Loveren, Henk & Klungel, Olaf H. (01.12.2011). Association Between Statin Use and Lupus-Like Syndrome Using Spontaneous Reports. Seminars in Arthritis and Rheumatism, 41 (3), (pp. 373-381) (9 p.).

Groenwold, Rolf H H, de Vries, Frank, de Boer, Anthonius, Pestman, Wiebe R, Rutten, Frans H, Hoes, Arno W & Klungel, Olaf H (01.11.2011). Balance measures for propensity score methods - a clinical example on beta-agonist use and the risk of myocardial infarction. Pharmacoepidemiology andDrug Safety, 20 (11), (pp. 1130-1137) (8 p.). Copyright © 2011 John Wiley & Sons, Ltd..

Wangge, Grace, Klungel, Olaf H., Roes, Kit C.B., De Boer, Antonius, Hoes, Arno W. & Knol, Mirjam J. (13.12.2011). Challenges of defining a non-inferiority margin: A case study of non-inferiority randomized controlled trials of oral anti-thrombolytic agents for prophylaxis of venous thromboembolic events after orthopedic surgery. Trials, 12 (suppl 1), (pp. A32-A32) (1 p.).

Harmsze, A.M., VanWerkum, J.W., Souverein, P.C., Bouman, H.J., Hackeng, C.M., Ruven, H.J.T., TenBerg, J.M., Klungel, O.H., de Boer, Anthonius & Deneer, V.H.M. (01.08.2011). Combined influence of PPIs, CCBs and CYP2C19*2 on on-treatment platelet reactivitiy and on the occurrence of atherothrombotic events in patients undergoing coronary stent implantation. European Heart Journal, 32, (pp. 239-240) (2 p.).

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Eussen, S.R.B.M., Feenstra, T.L., Toxopeus, I.B., Hoekstra, J., Klungel, O.H., Verhagen, H., van Kranen, H.J. & Rompelberg, C.J.M. (2011). Costs and health effects of adding functional foods containing phytosterols/-stanols to statin therapy in the prevention of cardiovascular disease. European Journal of Pharmacology, 668, (pp. S91-S100) (10 p.).

Eussen, Simone R B M, de Jong, Nynke, Rompelberg, Cathy J M, Garssen, Johan, Verschuren, W MMonique & Klungel, Olaf H (01.10.2011). Dose-dependent cholesterol-lowering effects of phytosterol/phytostanol-enriched margarine in statin users and statin non-users under free-living conditions. Public Health Nutrition, 14 (10), (pp. 1823-1832) (10 p.).

Eussen, S.R.B.M., De Jong, N., Rompelberg, C.J.M., Garssen, J., Verschuren, W.M.M. & Klungel, O.H. (01.09.2011). Dose-dependent cholesterol-lowering effects of phytosterol/-stanol-enriched margarine in statin users and non-statin users under free-living conditions. European Journal of Pharmacology, 668, (pp. 5-6) (2 p.).

Knol, M.J., Vanderweele, T.J., Groenwold, R.H.H., Klungel, O.H., Rovers, M.M. & Grobbee, D.E. (2011). Estimating measures of interaction on an additive scale for preventive exposures. European Journal of Epidemiology, 26 (6), (pp. 433-438) (6 p.).

Eussen, S.R.B.M., Verhagen, H., Klungel, O.H., Garssen, J., van Loveren, H., van Kranen, H.J. & Rompelberg, C.J.M. (2011). Functional foods and dietary supplements: Products at the interface between pharma and nutrition. European Journal of Pharmacology, 688, (pp. S2-S9) (8 p.).

Peters, Bas J M, Pett, Helmi, Klungel, Olaf H, Stricker, Bruno H Ch, Psaty, Bruce M, Glazer, Nicole L, Wiggins, Kerri L, Bis, Josh C, de Boer, Anthonius & Maitland-van der Zee, Anke-Hilse (2011). Genetic variability within the cholesterol lowering pathway and the effectiveness of statins in reducing the risk of MI. Atherosclerosis, 217 (2), (pp. 458-464) (7 p.). Copyright © 2011 Elsevier Ireland Ltd. All rights reserved..

Maitland-Van Der Zee, Anke-Hilse, Van Wieren-De Wijer, Diane B.M.A., De Boer, Anthonius, Kroon, Abraham A., De Leeuw, Peter W., Schiffers, Paul, Janssen, Rob G.J.H., Psaty, Bruce M., Van Duijn, Cornelia M., Stricker, Bruno H.Ch. & Klungel, Olaf H. (01.09.2011). Genetic variation in the renin-angiotensin system, use of renin-angiotensin system inhibitors and the risk of myocardial infarction. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 12 (3), (pp. 208-214) (7 p.).

Eussen, Simone R B M, Bouvy, Marcel L, Rompelberg, Cathy J M, van der Elst, Menno E, Garssen, Johan, Oosterveld, Marco H, de Boer, Anthonius, de Gier, Johan J, van Kranen, Henk J & Klungel, Olaf H (2011). Influence of the use of functional foods enriched with phytosterols/-stanols on adherence to statin therapy. Pharmacoepidemiology and Drug Safety, 20 (8), (pp. 830-7) (8 p.). Copyright © 2011 John Wiley & Sons, Ltd..



Belitser, S., Martens, Edwin P., Pestman, Wiebe R., Groenwold, Rolf H.H., De Boer, Anthonius & Klungel, Olaf H. (01.08.2011). Measuring balance and model selection in propensity score methods. Pharmacoepidemiology and Drug Safety, 20 (11), (pp. 1115-1129) (15 p.).

Belitser, Svetlana V, Martens, Edwin P, Pestman, Wiebe R, Groenwold, Rolf H H, de Boer, Anthonius & Klungel, Olaf H (2011). Measuring balance and model selection in propensity score methods. Pharmacoepidemiology and Drug Safety, 20 (11), (pp. 1115-1129) (15 p.). Copyright © 2011 John Wiley & Sons, Ltd..

Lanktree, M.B., Guo, Y., Murtaza, M., Glessner, J.T., Bailey, S.D., Onland-Moret, N.C., Lettre, G., Ongen, H., Rajagopalan, R., Johnson, T., Shen, H., Nelson, C.P., Klopp, N., Baumert, J., Padmanabhan, S., Pankratz, N., Pankow, J.S., Shah, S., Taylor, K., Barnard, J., Peters, B.J.M., Maloney, C.M., Lobmeyer, M.T., Stanton, A, Zafarmand, M.H., Romaine, S.P., Mehta, A., van Iperen, E.P., Gong, Y, Price, T.S., Smith, E.N., Kim, C.E., Li, Y.R., Asselbergs, F.W., Atwood, L.D., Bailey, K.M.,Bhatt, D., Bauer, F., Behr, E.R., Bhangale, T., Boer, J.M., Boehm, B.O., Bradfield, J.P., Brown, M., Braund, P.S., Burton, P.R., Carty, C., Chandrupatla, H.R., Chen, W., Connell, J., Dalgeorgou, C., de Boer, A., Drenos, F., Elbers, C.C., Fang, J.C., Fox, C.S., Frackelton, E.C., Fuchs, B., Furlong, C.E., Gibson, Q., Gieger, C., Goel, A., Grobbee, D.E., Hastie, C., Howard, P.J., Huang, G.H., Johnson, W.C., Li, Q., Kleber, M.E., Klein, B.E., Klein, R., Kooperberg, C., Ky, B., Lacroix, A., Lanken, P., Lathrop, M., Li, M., Marshall, V., Melander, O., Mentch, F.D., Meyer, N.J., Monda, K.L., Montpetit, A., Murugesan, G., Nakayama, K., Nondahl, D., Onipinla, A., Rafelt, S., Newhouse, S.J., Otieno, F.G., Patel, S.R., Putt, M.E., Rodriguez, S., Safa, R.N., Sawyer, D.B., Maitland-van der Zee, A.H., Klungel, O.H., de Bakker, P.I.W. & van der Schouw, Y.T. (2011). Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88 (1), (pp. 6-18) (13 p.).

Eussen, Simone Rbm, Rompelberg, Cathy Jm, Klungel, Olaf H & Van Eijkeren, Jan Ch (14.01.2011). Modelling approach to simulate reductions in LDL cholesterol levels after combined intake of statins and phytosterols/-stanols in humans. Lipids in Health and Disease, 10.

Klungel, O. (01.11.2011). Mondriaan: A dutch 'population' laboratory. Value in Health, 14 (7), (pp. 423) (1 p.).

de Peuter, Olav R, Souverein, Patrick C, Klungel, Olaf H, Büller, Harry R, de Boer, Anthonius & Kamphuisen, Pieter W (2011). Non-selective vs. selective beta-blocker treatment and the risk of thrombo-embolic events in patients with heart failure. European Journal of Heart Failure, 13 (2), (pp. 220-6) (7 p.).

van der Baan, F.H., Klungel, O.H., Egberts, A.C.G., Leufkens, H.G.M., Grobbee, D.E., Roes, K.C.B. & Knol, M.J. (2011). Pharmacogenetics in randomized controlled trials: considerations for trial design. Pharmacogenomics, 12 (10), (pp. 1485-1492) (8 p.).

Groenwold, R.H.H., Klungel, O.H., Grobbee, D.E. & Hoes, A.W. (2011). Selection of confounding variables should not be based on observed associations with exposure. European Journal of Epidemiology, 26 (8), (pp. 589-593) (5 p.).

Eussen, S.R.B.M., Rompelberg, C.J.M., Andersson, K.E., Klungel, O.H., Hellstrand, P., Oste, R., van Kranen, H. & Garssen, J. (2011). Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-/- mice. Pharmacological Research, 64 (1), (pp. 36-43) (8 p.).

Eussen, S.R.B.M., Rompelberg, C.J.M., Andersson, K.E., Klungel, O.H., Hellstrand, P. & Öste, R. (01.09.2011). Simultaneous intake of oat bran and atorvastatin reduces their efficacy to lower lipid levels and atherosclerosis in LDLr-deficient mice. European Journal of Pharmacology, 668, (pp. 35-36) (2 p.).

Harmsze, A.M., van Werkum, J.W., Moral, F., Ten Berg, J.N., Hackeng, C.M., Klungel, O.H., de Boer, A. & Deneer, V.H.M. (2011). Sulfonylureas and on-clopidogrel platelet reactivity in type 2 diabetes mellitus patients. Platelets, 22 (2), (pp. 98-102) (5 p.).

De Peuter, O.R., Lip, G.Y., Souverein, P.C., Klungel, O.H., de Boer, A., Buller, H.R. & Kamphuisen, P.W. (2011). Time-trends in treatment and cardiovascular events in patients with heart failure: a pharmacosurveillance study. European Journal of Heart Failure, 13 (5), (pp. 489-95) (7 p.).

2011 - Professional publications

Harmsze, A.M., van Werkum, J.W., ten Berg, J.M., Ruven, H.J.T., Hackeng, C.M., Tjoeng, M.M., Klungel, O.H., de Boer, A. & Deneer, V.H.M. (2011). Effect van genetische variaties op de effectiviteit van clopidogrel. Pharmaceutisch Weekblad - Scientific Edition, 5 (5), (pp. a1111) (1 p.).


Eussen, Simone R.B.M., Van Der Elst, Menno E., Klungel, Olaf H., Rompelberg, Cathy J.M., Garssen,Johan, Oosterveld, Marco H., De Boer, Anthonius, De Gier, Johan J. & Bouvy, Marcel L. (01.12.2010).A pharmaceutical care program to improve adherence to statin therapy: A randomized controlled trial.



Annals of Pharmacotherapy, 44 (12), (pp. 1905-1913) (9 p.).

Eussen, Simone, Van Der Elst, Menno, Klungel, Olaf, Rompelberg, Cathy, Garssen, Johan, Oosterveld, Marco, De Boer, Anthonius, De Gier, Johan & Bouvy, Marcel (01.08.2010). A randomized controlled trial of the effect of a pharmaceutical care program on improving adherence to statin therapy: The statin intervention research project (STIPT). Pharmacoepidemiology and Drug Safety, 19, (pp. 35-36) (2 p.).

Harmsze, Ankie, van Werkum, Jochem W, Bouman, Heleen J, Ruven, Henk J, Breet, Nicolien J, Ten Berg, Jurrien M, Hackeng, Christian M, Tjoeng, Mathieu M, Klungel, Olaf H, de Boer, Anthonius & Deneer, Vera H (2010). Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation. Pharmacogenetics and Genomics, 20 (1), (pp. 18-25) (8 p.).

Harmsze, A.M., van Werkum, J.W., ten Berg, J.M., Zwart, B., Bouman, H.J., Breet, N.J., van 't Hof, A.W., Ruven, H.J., Hackeng, C.M., Klungel, O.H., de Boer, A. & Deneer, V.H.M. (2010). CYP2C19*2 and CYP2C9*3 alleles are associated with stent thrombosis: a case-control study. European Heart Journal, 31 (24), (pp. 3046-3053) (8 p.).

Eussen, S.R.B.M., de Jong, N., Rompelberg, C.J., Garssen, J., Verschuren, W.M. & Klungel, O.H. (2010). Effects of the use of phytosterol/-stanol-enriched margarines on adherence to statin therapy. Pharmacoepidemiology and Drug Safety, 19 (12), (pp. 1225-1232) (8 p.).

Taverne, Kim, de Groot, Mark, de Boer, Anthonius & Klungel, Olaf (2010). Genetic polymorphisms related to the renin-angiotensin-aldosterone system and response to antihypertensive drugs. Expert Opinion on Drug Metabolism and Toxicology, 6 (4), (pp. 439-60) (22 p.).

Harmsze, Ankie M, Deneer, Vera H, Maitland-van der Zee, Anke Hilse, de Boer, Anthonius & Klungel, Olaf H (2010). Genetische variaties beïnvloeden effectiviteit en veiligheid van geneesmiddelen. Nederlands Tijdschrift voor Geneeskunde, 154 (A1503), (pp. A1503).

Groenwold, R.H.H., Hak, E., Klungel, O.H. & Hoes, A.W. (2010). Instrumental variables in influenza vaccination studies: mission impossible?!. Value in Health, 13 (1), (pp. 132-137) (6 p.).

Wangge, G, Klungel, O H, Roes, K C B, de Boer, A, Hoes, A W & Knol, M J (2010). Interpretation and inference in noninferiority randomized controlled trials in drug research. Clinical Pharmacology and Therapeutics, 88 (3), (pp. 420-423) (4 p.).

Peters, Bas J M, Rodin, Andrei S, Klungel, Olaf H, van Duijn, Cornelia M, Stricker, Bruno H Ch, van't Slot, Ruben, de Boer, Anthonius & Maitland-van der Zee, Anke-Hilse (2010). Pharmacogenetic interactions between ABCB1 and SLCO1B1 tagging SNPs and the effectiveness of statins in the prevention of myocardial infarction. Pharmacogenomics, 11 (8), (pp. 1065-1076) (12 p.).

Wangge, Grace, Klungel, Olaf H, Roes, Kit C B, de Boer, Anthonius, Hoes, Arno W & Knol, Mirjam J (27.10.2010). Room for improvement in conducting and reporting non-inferiority randomized controlled trials on drugs - a systematic review. PLoS One, 5 (10), (pp. e13550) (1 p.).

Eussen, S.R.B.M., Klungel, O.H., Garssen, J., Verhagen, H., van Kranen, H., van Loveren, H. & Rompelberg, C.J. (2010). Support of drug therapy using functional foods and dietary supplements: focus on statin therapy. British Journal of Nutrition, 103, (pp. 1260-1277) (18 p.).

Harmsze, A.M., Robijns, K., van Werkum, J.W., Breet, N.J., Hackeng, C.M., ten Berg, J.M., Ruven, H.J.T., Klungel, O.H., de Boer, A. & Deneer, V.H.M. (2010). The use of amlodipine, but not of P-glycoprotein inhibiting calcium channel blockers is associated with clopidogrel poor-response. Thrombosis and Haemostasis, 103, (pp. 920-925) (6 p.).

Peters, B.J.M., Rodin, A.S., Klungel, O.H., Stricker, B.H.Ch, Bruno, H.Ch., de Boer, A. & Maitland-van der Zee, A.H. (2010). Variants of ADAMTS1 modify the effectiveness of statins in reducing the risk of myocardial infarction. Pharmacogenetics and Genomics, 20 (12), (pp. 766-774) (9 p.).


Milder, I.E.J., Klungel, O.H., Mantel-Teeuwisse, A.K., Verschuren, W.M.M. & Bemelmans, W.J.E. (2010). Relation between body mass index, physical inactivity and use of prescription drugs: the Doetinchem Cohort Study. International Journal of Obesity, (pp. 1-10) (10 p.).


van Bruggen, J.A.R., Gorter, K.J., Stolk, R.P., Klungel, O.H. & Rutten, G.E.H.M. (2009). Clinical inertia in general practice: widespread and related to the outcome of diabetes care. Family Practice, 26 (4), (pp. 428-436) (9 p.).

Vink, N.M., Klungel, O.H., Stolk, P. & Denig, P. (2009). Comparison of various measures for assessingmedication refill adherence using prescription data. Pharmacoepidemiology and Drug Safety, 18, (pp. 159-165) (7 p.).

van Wieren-de Wijer, D B M A, Maitland-van der Zee, A H, de Boer, A, Belitser, S V, Kroon, A A, de



Leeuw, P W, Schiffers, P, Janssen, R G J H, van Duijn, C M, Stricker, B H C H & Klungel, O H (2009). Determinants of DNA yield and purity collected with buccal cell samples. European Journal of Epidemiology, 24 (11), (pp. 677-82) (6 p.).

Peters, Bas J M, Klungel, Olaf H, de Boer, Anthonius & Maitland-van der Zee, Anke-Hilse (2009). Genetic determinants of response to statins. Expert Review of Cardiovascular Therapy, 7 (8), (pp. 977-983) (7 p.).

van Wieren-de Wijer, B.M.A., Maitland-van der Zee, A.H., de Boer, A., Kroon, A.A., de Leeuw, P.W., Schiffers, P.M., Janssen, R.G.J.H., Psaty, B.M., van Duijn, C.M., Stricker, B.H.Ch. & Klungel, O.H. (2009). Interaction between the Fly460Trp a-adducin gene variant and diuretics on the risk of myocardial infarction. Journal of Hypertension, 27, (pp. 61-68) (8 p.).

van Wieren-de Wijer, Diane B M A, Maitland-van der Zee, Anke-Hilse, de Boer, Anthonius, Kroon, Abraham A, de Leeuw, Peter W, Schiffers, Paul, Janssen, Rob G J H, Psaty, Bruce M, van Duijn, Cornelia M, Stricker, Bruno H Ch & Klungel, Olaf H (2009). Interaction between the Gly460Trp alpha-adducin gene variant and diuretics on the risk of myocardial infarction. Journal of Hypertension, 27 (1),(pp. 61-8) (8 p.).

Peters, Bas J M, Klungel, Olaf H, de Boer, Anthonius, Ch Stricker, Bruno H & Maitland-van der Zee, Anke-Hilse (2009). Pharmacogenetics of cardiovascular drug therapy. Clinical Cases in Mineral and Bone Metabolism, 6 (1), (pp. 55-65) (11 p.).

Peters, Bas Jm, Klungel, Olaf H, Visseren, Frank L, de Boer, Anthonius & Maitland-van der Zee, Anke-Hilse (2009). Pharmacogenomic insights into treatment and management of statin-induced myopathy. Genome Medicine, 1 (12), (pp. 120).

van Wieren-de Wijer, Diane B M A, Maitland-van der Zee, Anke-Hilse, de Boer, Anthonius, Kroon, Abraham A, de Leeuw, Peter W, Schiffers, Paul, Janssen, Rob G J H, Psaty, Bruce M, van Duijn, Cornelia M, Stricker, Bruno H Ch & Klungel, Olaf H (2009). Reasons for non-response in observational pharmacogenetic research. Pharmacoepidemiology and Drug Safety, 18 (8), (pp. 665-71) (7 p.). Copyright 2009 John Wiley & Sons, Ltd..

van Wieren-de Wijer, Diane B M A, Maitland-van der Zee, Anke-Hilse, de Boer, Anthonius, Stricker, Bruno H Ch, Kroon, Abraham A, de Leeuw, Peter W, Bozkurt, O & Klungel, Olaf H (2009). Recruitment of participants through community pharmacies for a pharmacogenetic study of antihypertensive drug treatment. Pharmacy World and Science, 31 (2), (pp. 158-164) (7 p.).

van Bruggen, J.A.R., Gorter, K.J., Stolk, R.P., Zuithoff, P., Klungel, O.H. & Rutten, G.E.H.M. (2009). Refill adherence and polypharmacy among patients with type 2 diabetes in general practice. Pharmacoepidemiology and Drug Safety, 18 (11), (pp. 983-991) (9 p.).

Bozkurt, Ozlem, de Boer, Anthonius, Grobbee, Diederik E, Kroon, Abraham A, Schiffers, Paul, de Leeuw, Peter & Klungel, Olaf H (2009). Renin-angiotensin system polymorphisms and the associationbetween use of angiotensin II receptor blockers or angiotensin-converting enzyme inhibitors and the risk of diabetes. JRAAS - Journal of the Renin-Angiotensin-Aldosterone System, 10 (2), (pp. 101-8) (8 p.).

Bozkurt, O., de Boer, A., Grobbee, D.E., de Leeuw, P.W., Kroon, A.A., Schiffers, P.M. & Klungel, O.H. (2009). Variation in Renin-Angiotensin System and Salt-Sensitivity Genes and the Risk of Diabetes Mellitus Associated With the Use of Thiazide Diuretics. American Journal of Hypertension, 22 (5), (pp. 545-551) (7 p.).


Klungel, O.H. & de Boer, A. (2009). Wel nadere studie nodig rol statines bij diabetes. Visie op statines blijft overeind. Pharmaceutisch Weekblad, februari, (pp. 16-20) (5 p.).


van Wijk, B.L.G., Shrank, W.H., Klungel, O.H., Schneeweiss, S., Brookhart, A.M. & Avorn, J. (2008). Across-national study of the persistence of antihypertensive medication use in the elderly. Journal of Hypertension, 26, (pp. 145-153) (9 p.).

van Wieren-de Wijer, B.M.A., Klungel, O.H. & Maitland-van der Zee, A.H. (2008). Are there interactions between the Gly460Trp alpha-adducin gene variant and the use of diuretics?. Personalized Medicine, 5 (2), (pp. 117-121) (5 p.).

Martens, Edwin P, de Boer, Anthonius, Pestman, Wiebe R, Belitser, Svetlana V, Stricker, Bruno H Ch & Klungel, Olaf H (2008). Comparing treatment effects after adjustment with multivariable Cox proportional hazards regression and propensity score methods. Pharmacoepidemiology and Drug Safety, 17 (1), (pp. 1-8) (8 p.).

Schalekamp, Tom, Klungel, Olaf H, Souverein, Patrick C & de Boer, Anthonius (2008). Effect of oral antiplatelet agents on major bleeding in users of coumarins. Thrombosis and Haemostasis, 100 (6),



(pp. 1076-1083) (8 p.).

Peters, Bas J M, Maitland-van der Zee, Anke-Hilse, Stricker, Bruno H Ch, van Wieren-de Wijer, Diane B M A, de Boer, Anthonius, Kroon, Abraham A, de Leeuw, Peter W, Schiffers, Paul, Janssen, Rob G JH, van Duijn, Cornelia M & Klungel, Olaf H (2008). Effectiveness of statins in the reduction of the risk of myocardial infarction is modified by the GNB3 C825T variant. Pharmacogenetics and Genomics, 18 (7), (pp. 631-636) (6 p.).

Bozkurt, O, Verschuren, W M M, van Wieren-de Wijer, B M A, Knol, M J, de Boer, A, Grobbee, D E, Geerlings, M I, Heerdink, E R & Klungel, O H (2008). Genetic variation in the renin-angiotensin systemmodifies the beneficial effects of ACE inhibitors on the risk of diabetes mellitus among hypertensives. Journal of Human Hypertension, 22 (11), (pp. 774-780) (7 p.).

Schalekamp, Tom, Klungel, Olaf H, Souverein, Patrick C & de Boer, Anthonius (28.01.2008). Increased Bleeding Risk With Concurrent Use of Selective Serotonin Reuptake inhibitors and Coumarins. Archives of Internal Medicine, 168 (2), (pp. 180-185) (6 p.).

Schelleman, H, Klungel, O H, Witteman, J C M, Breteler, M M B, Hofman, A, van Duijn, C M, de Boer, A & Stricker, B H Ch (2008). Interaction between polymorphisms in the renin-angiotensin-system and angiotensin-converting enzyme inhibitor or beta-blocker use and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 8 (6), (pp. 400-7) (8 p.).

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., van Duijn, C.M., de Boer, A. & Stricker, B.H.Ch. (2008). Interaction between polymorphisms in the renin-angiotensin-system and angiotensin-converting enzyme inhibitor or ß-blocker use and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 6 (1), (pp. 22-26) (5 p.).

Klungel, O.H., Storimans, M.J., Floor-Schreudering, A., Talsma, H., Rutten, G.E.H.M. & de Blaey, C.J. (2008). Perceived diabetes status is independently associated with glucose monitoring behaviour among type 2 diabetes mellitus patients. Primary Care Diabetes, 2, (pp. 25-30) (6 p.).

Swen, J J, Wilting, I, de Goede, A L, Grandia, L, Mulder, H, Touw, D J, de Boer, A, Conemans, J M H, Egberts, T C G, Klungel, O H, Koopmans, R, van der Weide, J, Wilffert, B, Guchelaar, H-J & Deneer, V H M (2008). Pharmacogenetics - from bench to byte. Clinical Pharmacology and Therapeutics, 83 (5), (pp. 781-787) (7 p.).

Martens, E.P., Pestman, W.R., de Boer, A., Belitser, S. & Klungel, O.H. (2008). Systematic differences in treatment effect estimates between propensity score methods and logistic regression. International Journal of Epidemiology, 37, (pp. 1142-1147) (6 p.).

Derijks, H.J., Heerdink, E.R., de Koning, F.H., Janknegt, R., Klungel, O.H. & Egberts, A.C.G. (2008). The association between antidepressant use and hypoglycaemia in diabetic patients: a nested case-control study. Pharmacoepidemiology and Drug Safety, 2008 (17), (pp. 336-344) (9 p.).

de Vries, F., Pouwels, S., Bracke, M., Lammers, J.W.J., Leufkens, H.G.M., Klungel, O.H. & van Staa, T.P. (2008). Use of inhaled corticosteroids and the risk of non-fatal acute myocardial infarction. Journalof Hypertension, 26, (pp. 124-129) (6 p.).

de Vries, Frank, Pouwels, Sander, Bracke, Madelon, Lammers, Jan-Willem, Klungel, Olaf, Leufkens, Hubert & van Staa, Tjeerd (2008). Use of ß2 agonists and risk of acute myocardial infarction in patients with hypertension. British Journal of Clinical Pharmacology, 65 (4), (pp. 580-586) (7 p.).


Klungel, O.H. & de Boer, A. (2008). Publieksmedia zaaien nieuwe onrust onder statinegebruikers. Primaire preventie zinvoller dan gemeld. Pharmaceutisch Weekblad, 7, (pp. 14-16) (3 p.).

Klungel, O.H. & de Boer, A. (2008). Reacties Onderwaardering. Pharmaceutisch Weekblad, 16, (pp. 10) (1 p.).


Maitland-van der Zee, A.H., Boerwinkle, E., Arnett, D.K., Davis, B.R., Leiendecker-Foster, C., Miller, M.B., Klungel, O.H., Ford, C.E. & Eckfeldt, J.H. (2007). Absence of an interaction between the angiotensinconverting enzyme insertion-deletion polymorphism and pravastatin on cardiovascular disease in high-risk hypertensive patients: The Genetics of Hypertension-Associated Treatment (GenHAT) study. American Heart Journal, 153, (pp. 54-58) (5 p.).

Schelleman, Hedi, Klungel, Olaf H, Witteman, Jacqueline C M, Breteler, Monique M B, Yazdanpanah, Moygan, Danser, A H Jan, Hofman, Albert, van Duijn, Cornelia M, de Boer, Anthonius & Stricker, Bruno H Ch (2007). Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers. European Journal of Human Genetics, 15 (4), (pp. 478-484) (7 p.).

Martens, E.P., Pestman, W.R. & Klungel, O.H. (2007). Conditioning on the propensity score can result in biased estimation of common measures of treatment effect: a Monte Carlo study (p n/a) by Austin



PC et al. Statistics in Medicine, 26, (pp. 3208-3210) (3 p.).

Knol, M.J., Heerdink, E.R., Egberts, A.C.G., Geerlings, M.I., Gorter, K.J., Numans, M.E., Grobbee, D.E., Klungel, O.H. & Burger, H (2007). Depressive symptoms in subjects with diagnosed and undiagnosed Type 2 diabetes. Psychosomatic Medicine, 69 (4), (pp. 300-305) (6 p.).

Storimans, M.J., Klungel, O.H., Talsma, H. & de Blaey, C.J. (2007). Differences in the association between structural factors and diabetes self-monitoring support. Pharmacy World and Science, 29 (6),(pp. 676-682) (7 p.).

Schelleman, H, Klungel, O H, Witteman, J C M, Breteler, M M B, Hofman, A, van Duijn, C M, de Boer, A & Stricker, B H Ch (2007). Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, 7 (5), (pp. 346-52) (7 p.).

Gumbs, Pearl D, Verschuren, Monique W M, Mantel-Teeuwisse, Aukje K, de Wit, Ardine G, de Boer, Anthonius & Klungel, Olaf H (2007). Economic evaluations of cholesterol-lowering drugs - a critical and systematic review. PharmacoEconomics, 25 (3), (pp. 187-199) (13 p.).

Yazdanpanah, M., Aulchenko, YS, Hofman, A., Janssen, J.A., A Sayed-Tabatabaei, F., van Schaik, R.H., Klungel, O.H., Stricker, B.H.Ch., Pols, H.A., Witteman, J.C., Lamberts, S.W.J., Oostra, B.A. & van Duijn, C.M. (2007). Effects of the renin-angiotensin system genes and salt sensitivity genes on bloodpressure and atherosclerosis in the total population and patients with type 2 diabetes. Diabetes, 56 (7), (pp. 1905-1912) (8 p.).

Isaacs, A, Aulchenko, YS, Hofman, A., Sijbrands, E.J., A Sayed-Tabatabaei, F., Klungel, O.H., Maitland-van der Zee, A.H., Stricker, B.H.Ch., Oostra, B.A., Witteman, J.C. & van Duijn, C.M. (2007). Epistatic Effect of CEPT and LIPC on Serum HDL Levels: The Rotterdam Study. Journal of Clinical Endocrinology and Metabolism, 92, (pp. 2680-2687) (8 p.).

de Jong, N, Klungel, O.H., Verhagen, H., Wolfs, M.C.J., Ocké, M.C. & Leufkens, H.G.M. (2007). Functional foods: the case for closer evaluation. BMJ (International edition), 334, (pp. 1037-1039) (3 p.).

Van Wijk, B.L.G., Avorn, J., Solomon, D.H., Klungel, O.H., Heerdink, E.R., de Boer, Anthonius & Brookhart, A.M. (21.09.2007). Herstarten van antihypertensiva. Pharmaceutisch Weekblad, 142 (38), (pp. 118-120) (3 p.).

Schelleman, H, Klungel, O H, Witteman, J C M, Hofman, A, van Duijn, C M, de Boer, A & Stricker, B HCh (2007). Pharmacogenetic interactions of three candidate gene polymorphisms with ACE-inhibitors or ß-blockers and the risk of atherosclerosis. British Journal of Clinical Pharmacology, 64 (1), (pp. 57-66) (10 p.).

Bozkurt, Ozlem, de Boer, Anthonius, Grobbee, Diederick E, Heerdink, Eibert R, Burger, Huib & Klungel, Olaf H (2007). Pharmacogenetics of glucose-lowering drug treatment - a systematic review. Molecular Diagnosis and Therapy, 11 (5), (pp. 291-302) (12 p.).

Bozkurt, O., de Boer, A., Grobbee, D.E., Heerdink, E.R., Burger, H. & Klungel, O.H. (2007). Pharmacogenetics of glucose-lowering drug treatment: a systematic review. Molecular Diagnosis and Therapy, 11 (8), (pp. 291-302) (12 p.).

van Rijn, MJ, Bos, M.J., Isaacs, A, Yazdanpanah, M., Arias-Vásquez, A., Stricker, B.H.Ch., Klungel, O.H., Oostra, B.A., Koudstaal, P.J., Witteman, J.C., Hofman, A., Breteler, M.M.B. & van Duijn, C.M. (2007). Polymorphisms of the renin-angiotensin system are associated with blood pressure, atherosclerosis and cerebral white matter pathology. Journal of Neurology, Neurosurgery and Psychiatry, 78 (10), (pp. 1083-1087) (5 p.).

van Wijk, Boris L G, Avorn, Jerry, Solomon, Daniel H, Klungel, Olaf H, Heerdink, Eibert R, de Boer, Anthonius & Brookhart, Alan M (2007). Rates and determinants of reinitiating antihypertensive therapyafter prolonged stoppage - a population-based study. Journal of Hypertension, 25 (3), (pp. 689-697) (9p.).

Gumbs, Pearl D, Verschuren, W M Monique, Souverein, Patrick C, Mantel-Teeuwisse, Aukje K, de Wit, G Ardine, de Boer, Anthonius & Klungel, Olaf H (2007). Society already achieves economic benefits from generic substitution but fails to do the same for therapeutic substitution. British Journal ofClinical Pharmacology, 64 (5), (pp. 680-685) (6 p.).

Isaacs, A, Aulchenko, YS, Hofman, A., Sijbrands, E.J., A Sayed-Tabatabaei, F., Klungel, O.H., Maitland-van der Zee, A.H., Stricker, B.H.Ch., Oostra, B.A., Witteman, J.C. & van Duijn, C.M. (2007). The CETP 1405V Polymorphism Is Associated with Increased HDL Levels and Decreased Risk of Myocardial Infarction: The Rotterdam Study. European Journal of Cardiovascular Prevention and Rehabilitation, 14 (3), (pp. 419-421) (3 p.).

Dobre, D., van Veldhuisen, D.J., DeJongste, M.J., van Sonderen, E., Klungel, O.H., Sanderman, R., Ranchor, A.V. & Haaijer-Ruskamp, F. (2007). The contribution of observational studies to the knowledge of drug effectiveness in heart failure. British Journal of Clinical Pharmacology, 64 (4), (pp.



406-414) (9 p.).


Van Wijk, Boris L G, Klungel, Olaf H, Heerdink, Eibert R & de Boer, Anthonius (2006). A comparison oftwo multiple-characteristic decision-making models for the comparison of antihypertensive drug classes - Simple Additive Weighting (SAW) and Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS). American Journal of Cardiovascular Drugs, 6 (4), (pp. 251-258) (8 p.).

Schalekamp, Tom, Boink, Gerard J J, Visser, Loes E, Stricker, Bruno H Ch, de Boer, Anthonius & Klungel, Olaf H (2006). CYP2C9 genotyping in acenocoumarol treatment - is it a cost-effective addition to international normalized ratio monitoring?. Clinical Pharmacology and Therapeutics, 79 (6),(pp. 511-520) (10 p.).

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Breteler, M.M.B., Hofman, A., van Duijn, C.M., de Boer, A. & Stricker, B.H.Ch. (2006). Diuretic-gene interaction and the risk of myocardial infarction and stroke. Pharmacogenomics Journal, (pp. 1-7) (7 p.).

Gumbs, Pearl D, Verschuren, W M Monique, Mantel-Teeuwisse, Aukje K, de Wit, Ardine G, Hofman, Albert, Trienekens, Paul H, Stricker, Bruno H Ch, de Boer, Antonius, Klungel, Olaf H & de Boer, Anthonius (2006). Drug Costs Associated with Non-Adherence to Cholesterol Management Guidelines for Primary Prevention of Cardiovascular Disease in an Elderly Population - the Rotterdam study. Drugs and Aging, 23 (9), (pp. 733-741) (9 p.).

Schelleman, Hedi, Klungel, Olaf H, van Duijn, Cornelia M, Witteman, Jacqueline C M, Hofman, Albert,de Boer, Anthonius & Stricker, Bruno H Ch (2006). Drug-gene interaction between the insertion/deletion polymorphism of the angiotensin-converting enzyme gene and antihypertensive therapy. Annals of Pharmacotherapy, 40 (2), (pp. 212-218) (7 p.).

Van Wijk, Boris L G, Klungel, Olaf H, Heerdink, Eibert R & de Boer, Anthonius (2006). Generic substitution of antihypertensive drugs - does it affect adherence?. Annals of Pharmacotherapy, 40 (1), (pp. 15-20) (6 p.).

Van Wijk, Boris L G, Klungel, Olaf H, Heerdink, Eibert R & de Boer, Anthonius (2006). Initial non-compliance with antihypertensive monotherapy is followed by complete discontinuation of antihypertensive therapy. Pharmacoepidemiology and Drug Safety, 15 (8), (pp. 587-93) (7 p.). Copyright 2006 John Wiley & Sons, Ltd..

Martens, Edwin P, Pestman, Wiebe R, de Boer, Anthonius, Belitser, Svetlana V & Klungel, Olaf H (2006). Instrumental variables - application and limitations. Epidemiology, 17 (3), (pp. 260-7) (8 p.).

Martens, E.P., Pestman, W.R., de Boer, A., Belitser, S. & Klungel, O.H. (2006). Instrumental Variables. Application and limitations. Epidemiology, 17 (3), (pp. 260-267) (8 p.).

Mantel-Teeuwisse, Aukje K, Klungel, Olaf H, Hofman, Albert, Verschuren, W M Monique, Trienekens, Paul H, Porsius, Arijan J, Stricker, Bruno H Ch & de Boer, Anthonius (2006). Prescribing behaviour according to Dutch and European guidelines on the management of hypercholesterolaemia (1992-1999). British Journal of Clinical Pharmacology, 61 (5), (pp. 592-600) (9 p.).

Van Wijk, Boris L G, Klungel, Olaf H, Heerdink, Eibert R & de Boer, Anthonius (2006). Refill persistence with chronic medication assessed from a pharmacy database was influenced by method of calculation. Journal of Clinical Epidemiology, 59 (1), (pp. 11-17) (7 p.).

Storimans, M.J., Klungel, O.H., Talsma, H. & de Blaey, C.J. (2006). Regional influences on the dispensing of glucose test strips in Dutch community pharmacies. Pharmacy World and Science, 28, (pp. 26-32) (7 p.).

Schelleman, H., Klungel, O.H., Witteman, J.C.M., Hofman, A., van Duijn, C.M., de Boer, A. & Stricker, B.H.Ch (2006). The influence of the alpha-adducin G460W polymorphism and angiotensinogen M235T polymorphism on antihypertensive medication and blood pressure. European Journal of Human Genetics, 14, (pp. 860-866) (7 p.).


Mantel-Teeuwisse, A.K. & Klungel, O.H. (2006). Zijn cholesterolverlagende margarines werkzaam en is er een interactie met statines?. Internisten Vademecum, 11 (10).


Maitland-van der Zee, A.H., Turner, S.T., Schwartz, G.L., Chapman, A.B., Klungel, O.H. & Boerwinkle,E. (2005). A multilocus approach to the pharmacogenetics of thiazide diuretics. American Journal of PharmacoGenomics, 15 (5), (pp. 287-293) (7 p.).

Hommerson, Paul, Nedeljkovic, Srecko I, Klungel, Olaf H, de Boer, Anthonius, Ostojic, Miodrag C, Grujic, Miodrag Z, Vojvodic, Nikola M, Bloemberg, Bennie P M & Kromhout, Daan (2005). Cardiovascular drug use and differences in the incidence of cardiovascular mortality in elderly Serbianmen. Pharmacy World and Science, 27 (2), (pp. 124-128) (5 p.).



Storimans, M.J., Klungel, O.H., Talsma, H., Bouvy, M.L. & de Blaey, C.J. (2005). Collaborative Services Among Community Phamacies for Patients with Diabetes. Annals of Pharmacotherapy, 39.

Maitland-van der Zee, A.H., Turner, S.T., Schwartz, G.L., Chapman, A.B., Klungel, O.H. & Boerwinkle,E. (2005). Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects. American Journal of Hypertension, 18, (pp. 1077-1083) (7 p.).

Erkens, J.A., Panneman, M.M., Klungel, O.H., van den Boom, G., Prescott, M.F. & Herings, R.M.C. (2005). Differences in antihypertensive drug persitence associated with drug class and gender: a PHARMO study. Pharmacoepidemiology and Drug Safety, 14 (11), (pp. 795-803) (9 p.).

Van Wijk, Boris Lg, Klungel, Olaf H, Heerdink, Eibert R & de Boer, Anthonius (2005). Effectiveness of interventions by community pharmacists to improve patient adherence to chronic medication - a systematic review. Annals of Pharmacotherapy, 39 (2), (pp. 319-28) (10 p.).

Maitland-van der Zee, A.H., Klungel, O.H. & de Boer, A. (2005). Genetic Polymorphisms and Response to HMG-CoA Reductase Inhibitors. In M.K. Raizada, J.F.R. Paton, S. Kasparov & M.J. Katovich (Eds.), Contemporary Cardiology: Cardiovascular Genomics (pp. 95-114) (362 p.). Totowa, New Jersey: Humana Press.

Schelleman, H, Klungel, O H, van Duijn, C M, Witteman, J C M, Hofman, A, de Boer, A & Stricker, B HCh (2005). Insertion/deletion polymorphism of the ACE gene and adherence to ACE inhibitors. British Journal of Clinical Pharmacology, 59 (4), (pp. 483-485) (3 p.).

Schelleman, H, Stricker, B H Ch, Verschuren, W M M, de Boer, A, Kroon, A A, de Leeuw, P W, Kromhout, D & Klungel, O H (30.11.2005). Interactions between five candidate genes and antihypertensive drug therapy on blood pressure. Pharmacogenomics Journal, 6 (1), (pp. 22-26) (5 p.).

Maitland-van der Zee, A.H., Turner, S.T., Schwartz, G.L., Chapman, A.B., Klungel, O.H. & Boerwinkle,E. (2005). Multilocus approach to the pharmacogenetics of thiazide diuretics. Circulation (pp. III-428) (1 p.).

Van Wijk, Boris Lg, Klungel, Olaf H, Heerdink, Eibert R & de Boer, Anthonius (2005). Rate and determinants of 10-year persistence with antihypertensive drugs. Journal of Hypertension, 23 (11), (pp. 2101-2107) (7 p.).

Mantel-Teeuwisse, A.K., Klungel, O.H., Schalekamp, T., Verschuren, W.M.M., Porsius, A.J. & de Boer,A. (2005). Suboptimal choices and dosing of statins at start of therapy. British Journal of Clinical Pharmacology, 60 (1), (pp. 83-89) (7 p.).


Gumbs, P.D., Verschuren, W.M.M., Mantel-Teeuwisse, A.K., de Boer, A. & Klungel, O.H. (2005). Medicamenteuze behandeling van hypercholesterolemie kosteneffectief. Pharmaceutisch Weekblad, 32, (pp. 982-983) (2 p.).

Wu, H.L., Nijssen, L.E., van der Salm, A., Denee, T.R., de Boer, A. & Klungel, O.H. (2005). Statines bijacuut coronair syndroom. Pharmaceutisch Weekblad, 32, (pp. 995-997) (3 p.).

Mantel-Teeuwisse, A.K. & Klungel, O.H. (2005). Zijn cholesterolverlagende margarines werkzaam en is er een interactie met statines?. Cardiologen Vademecum, 9 (3).

Mantel-Teeuwisse, A.K. & Klungel, O.H. (2005). Zijn Cholesterolverlagende margarines werkzaam en is er een interactie met statines?. Apothekers vademecum, 1 (6).


Erkens, J.A., Klungel, O.H., Stolk, R.P., Spoelstra, J.A., Grobbee, D.E. & Leufkens, H.G.M. (2004). Antihypertensive drug therapy and the risk of lower extremity amputations in pharmacologically treated type 2 diabetes patients. Pharmacoepidemiology and Drug Safety, 13, (pp. 139-146) (8 p.).

Spoelstra, J.A., Stolk, R.P., Cohen, D., Klungel, O.H., Erkens, J.A., Leufkens, H.G.M. & Grobbee, D.E.(2004). Antipsychotic Drugs May Worsen Metabolic Control in Type 2 Diabetes Mellitus. Journal of Clinical Psychiatry, 65 (5), (pp. 674-678) (5 p.).

Maitland-van der Zee, Anke Hilse, Klungel, Olaf H, Stricker, Bruno H Ch, Verschuren, W M Monique, Witteman, Jacqueline C M, Stijnen, Theo, Hofman, Albert, Breteler, Monique M B, Leufkens, HubertusG M & de Boer, Anthonius (2004). Comparison of two methodologies to analyze exposure to statins inan observational study on effectiveness. Journal of Clinical Epidemiology, 57 (3), (pp. 237-242) (6 p.).

Storimans, M.J., Talsma, H., Klungel, O.H. & de Blaey, C.J. (2004). Dispensing glucose test materials in Dutch community pharmacies. Pharmacy World and Science, 26, (pp. 52-55) (4 p.).

Schelleman, Hedi, Stricker, Bruno H Ch, De Boer, Anthonius, Kroon, Abraham A, Verschuren, Monique W M, Van Duijn, Cornelia M, Psaty, Bruce M & Klungel, Olaf H (2004). Drug-Gene Interactions between Genetic Polymorphisms and Antihypertensive Therapy. Drugs, 64 (16), (pp.



1801-1816) (16 p.).

Maitland-van der Zee, Anke-Hilse, Klungel, Olaf H, Leufkens, Hubertus G M, de Boer, Anthonius, Stricker, Bruno H Ch, Hofman, Albert, Witteman, Jacqueline C M, van Duijn, Cornelia M & Kastelein, John J P (2004). Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism. Atherosclerosis, 175 (2), (pp. 377-379) (3 p.).

Mantel-Teeuwisse, Aukje K, Klungel, Olaf H, Egberts, Toine C G, Verschuren, W M Monique, Porsius, Arijan J & de Boer, Anthonius (2004). Failure to Continue Lipid-Lowering Drug Use Following the Withdrawal of Cerivastatin. Drug Safety, 27 (1), (pp. 63-70) (8 p.).

Storimans, M.J., Klungel, O.H., Talsma, H. & de Blaey, C.J. (2004). Geographic region influences pharmacy's dispensing of blood glucose test strips. Annals of Pharmacotherapy, 38, (pp. 1751-1752) (2 p.).

Spoelstra, J.A., Stolk, R.P., Klungel, O.H., Erkens, J.A., Rutten, G.E.H.M., Leufkens, H.G.M. & Grobbee, D.E. (2004). Initiation of glucose-lowering therapy in Type 2 diabetes mellitus patients in general practice. Diabetic Medicine, 21, (pp. 896-900) (5 p.).

Mantel-Teeuwisse, A K, Goettsch, W G, Klungel, O H, de Boer, A & Herings, R M C (2004). Long termpersistence with statin treatment in daily medical practice. Heart, 90 (9), (pp. 1065-1066) (2 p.).

Klungel, Olaf H, Martens, Edwin P, Psaty, Bruce M, Grobbee, Diederik E, Sullivan, Sean D, Stricker, Bruno H Ch, Leufkens, Hubert G M & de Boer, A (2004). Methods to assess intended effects of drug treatment in observational studies are reviewed. Journal of Clinical Epidemiology, 57 (12), (pp. 1223-1231) (9 p.).

Maitland-van der Zee, Anke Hilse, Klungel, Olaf H, Stricker, Bruno H Ch, Veenstra, David L, Kastelein,John J P, Hofman, Albert, Witteman, Jacqueline C M, Leufkens, Hubertus G M, van Duijn, Cornelia M & de Boer, Anthonius (2004). Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men. Pharmacogenetics, 14 (1), (pp. 53-60) (8 p.).

Maitland-van der Zee, A.H., Klungel, O.H., Stricker, B.H.Ch., Veenstra, D.L., Kastelein, J.J.P., Hofman,A., Witteman, J.C.M., Leufkens, H.G.M., van Duijn, C.M. & de Boer, A. (2004). Pharmacoeconomic evaluation of testing for angiotensinconverting enzyme genotype before starting ß-hydrocy-ß-methylglutaryl coenzyme A reductase inhibitor therapy in men. Pharmacogenetics, 14, (pp. 53-60) (8 p.).

Maitland-van, der Zee Anke-Hilse, Klungel, Olaf H & de Boer, Anthonius (2004). Pharmacogenetics in health-care practice. Pharmacy World and Science, 26 (5), (pp. 253-5) (3 p.).

Maitland-van der Zee, A.H., Klungel, O.H. & de Boer, A. (2004). Pharmcogenetics in health-care practice. Pharmacy World and Science, 26, (pp. 253-255) (3 p.).

Schelleman, H, Klungel, O H, Kromhout, D, de Boer, A, Stricker, B H Ch & Verschuren, W M M (2004). Prevalence and determinants of undertreatment of hypertension in the Netherlands. Journal ofHuman Hypertension, 18 (5), (pp. 317-324) (8 p.).

Mantel-Teeuwisse, Aukje K, Verschuren, W M Monique, Klungel, Olaf H, de Boer, Anthonius & Kromhout, Daan (2004). Recent trends in (under)treatment of hypercholesterolaemia in the Netherlands. British Journal of Clinical Pharmacology, 58 (3), (pp. 310-316) (7 p.).

Florentinus, Stefan R, Heerdink, Eibert R, Klungel, Olaf H & de Boer, Anthonius (03.11.2004). Should rosuvastatin be withdrawn from the market?. The Lancet, 364 (9445), (pp. 1577; author reply 1578-9).

Florentinus, S.R., Heerdink, E.R., Klungel, O.H. & de Boer, A. (2004). Should rosuvastatin be withdrawn from the market?. The Lancet, 364, (pp. 1577-1580) (4 p.).

Goettsch, W.G., Yin, D.D., Alemao, E., Klungel, O.H., Stalenhoef, A.F. & Herings, R.M.C. (2004). Statins are less effective in common daily practice among patients with hypercholesterolemia: the REALITY-PHARMO study. Current Medical Research and Opinion, 20 (7), (pp. 1025-1033) (9 p.).

van Wijk, B.L.G., Klungel, O.H., Heerdink, E.R. & de Boer, A. (2004). The association between compliance with antihypertensive drugs and modification of antihypertensive drug regimen. Journal of Hypertension, 22, (pp. 1831-1837) (7 p.).


Mantel-Teeuwisse, A.K. & Klungel, O.H. (2004). Zijn cholesterol verlagende margarines werkzaam en is er een interactie met statines?. Apothekers vademecum, 5 (7).


Maitland-van der Zee, Anke-Hilse, Stricker, Bruno H Ch, Klungel, Olaf H, Mantel-Teeuwisse, Aukje K, Kastelein, John J P, Hofman, Albert, Leufkens, Hubertus G M, van Duijn, Cornelia M & de Boer, Anthonius (2003). Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes.



Pharmacogenetics, 13 (4), (pp. 219-23) (5 p.).

Maitland-van der Zee, A.H., Stricker, B.H.Ch, Klungel, O.H., Mantel-Teeuwisse, A.K., Kastelein, J.J.P., Hofman, A., Leufkens, H.G.M., van Duijn, C.M. & de Boer, A. (2003). Adherence to and dosing of ß-hydroxy-ß-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes. Pharmacogenetics, 13, (pp. 219-223) (5 p.).

Spoelstra, J.A., Stolk, R.P., Heerdink, E.R., Klungel, O.H., Erkens, J.A., Leufkens, H.G.M. & Grobbee, D.E. (2003). Refill compliance in type 2 diabetes mellitus: a predictor of switching to insulin therapy. Pharmacoepidemiology and Drug Safety, 12, (pp. 121-127) (7 p.).

Maitland-van der Zee, Anke Hilse, Klungel, Olaf H, Stricker, Bruno H Ch, van der Kuip, Deirdre A M, Witteman, Jacqueline C M, Hofman, Albert, Leufkens, Hubertus G M & de Boer, Anthonius (2003). Repeated nitrate prescriptions as a potential marker for angina pectoris. A comparison with medical information from the Rotterdam Study. Pharmacy World and Science, 25 (2), (pp. 70-72) (3 p.).

Maitland-van der Zee, A.H., Stricker, B.H.Ch, Klungel, O.H., Kastelein, J.J.P., Hofman, A., Witteman, J.C.M., Breteler, M.M.B., Leufkens, H.G.M., van Duijn, C.M. & de Boer, A. (2003). The effectiveness ofhydroxy-methylglutaryl coenzyme A reductase inhibitors (statins) in the elderly is not influenced by apolipoprotein E genotype. Pharmacogenetics, 12, (pp. 647-653) (7 p.).

Mantel-Teeuwisse, A.K., Verschuren, W.M.M., Klungel, O.H., Kromhout, D., Lindemans, A.D., Avorn, J., Porsius, A.J. & de Boer, A. (2003). Undertreatment of hypercholesterolaemia: a population-based study. British Journal of Clinical Pharmacology, 55, (pp. 389-397) (9 p.).


Klungel, O.H., Mantel-Teeuwisse, A.K. & de Boer, A. (2003). Medicamenteuze behandeling van hypertensie en hypercholesterolemie. Sekseverschillen in epidemiologie, risico en therapie. Pharmaceutisch Weekblad, 138 (40), (pp. 1383-1389) (7 p.).

Erkens, J.A., Klungel, O.H., Stolk, R.P., Grobbee, D.E. & Leufkens, H.G.M. (2003). Multifactoriële behandeling van diabetes mellitus type 2. Belaagd aan alle zijden. Pharmaceutisch Weekblad, 138 (45), (pp. 1574-1578) (5 p.).


Maitland-van der Zee, Anke Hilse, Klungel, Olaf H, Stricker, Bruno H Ch, Monique Verschuren, W M, Kastelein, John J P, Leufkens, Hubertus G M & de Boer, Anthonius (2002). Genetic polymorphisms - importance for response to HMG-CoA reductase inhibitors. Atherosclerosis, 163 (2), (pp. 213-22) (10 p.).

Maitland-van der Zee, A.H., Klungel, O.H., Stricker, B.H.Ch., Verschuren, W.M.M., Kastelein, J.J.P., Leufkens, H.G.M. & de Boer, A. (2002). Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors. Atherosclerosis, 163, (pp. 213-222) (10 p.).

Klungel, Olaf H, Heckbert, Susan R, de Boer, Anthonius, Leufkens, Hubert G M, Sullivan, Sean D, Fishman, Paul A, Veenstra, David L & Psaty, Bruce M (2002). Lipid-lowering drug use and cardiovascular events after myocardial infarction. Annals of Pharmacotherapy, 36 (5), (pp. 751-7) (7 p.).

Mantel-Teeuwisse, Aukje K, Klungel, Olaf H, Herings, Ron M C, van Puijenbroek, Eugène P, Porsius, Arijan J & de Boer, Anthonius (2002). Myopathy due to statin/fibrate use in the Netherlands. Annals of Pharmacotherapy, 36 (12), (pp. 1957-1960) (4 p.).

Klungel, O.H. (2002). Quality of hypertension treatment and risk of stroke in the general population. Journal of Hypertension, 20, (pp. 1949-1950) (2 p.).

Maitland-van der Zee, A.H., Stricker, B.H.Ch., Klungel, O.H., Kastelein, J.J.P., Hofman, A., Witteman, J.C.M., Breteler, M.M.B., Leufkens, H.G.M., van Duijn, C.M. & de Boer, A. (2002). The effectiveness ofHydroxy-Methylglutaryl Coenzyme A reductase inhibitors in the elderly is not influenced by Apolipoprotein E-genotypes. Pharmacogenetics, 12 (8), (pp. 647-653) (7 p.).

Mantel-Teeuwisse, A.K., Klungel, O.H., Verschuren, W.M.M., Porsius, A.J. & de Boer, A. (2002). Time trends in lipid lowering drug use in The Netherlands. Has the backlog of candidates for treatment beeneliminated?. British Journal of Clinical Pharmacology, 53, (pp. 379-385) (7 p.).

Erkens, J.A., Klungel, O.H., Herings, R.M.C., Stolk, R.P., Spoelstra, J.A., Grobbee, D.E. & Leufkens, H.G.M. (2002). Use of fluorquinolones is associated with a reduced risk of coronary heart disease in diabetes mellitus type 2 patients. European Heart Journal, 23, (pp. 1575-1579) (5 p.).


Herings, R.M.C. & Klungel, O.H. (2001). An epidemiological approach to assess the economic burdenof NSAID-induced gastrointestinal events in the Netherlands. PharmacoEconomics, 19 (6), (pp. 655-665) (11 p.).

Klungel, O H, Heckbert, S R, Longstreth, W T, Furberg, C D, Kaplan, R C, Smith, N L, Lemaitre, R N,



Leufkens, H G, de Boer, A & Psaty, B M (08.01.2001). Antihypertensive Drug Therapies and the Risk of Ischemic Stroke. Archives of Internal Medicine, 161 (1), (pp. 37-43) (7 p.).

Erkens, J.A., Klungel, O.H., Stolk, R.P., Herings, R.M.C., Spoelstra, J.A., Grobbee, D.E. & Leufkens, H.G.M. (2001). Cardiovascular drug use and complications attributable to diabetes mellitus type 2. Diabetes Care, 24, (pp. 1428-1432) (5 p.).

Mantel-Teeuwisse, A K, Klungel, O H, Verschuren, W M, Porsius, A & de Boer, A (2001). Comparison of different methods to estimate prevalence of drug use by using pharmacy records. Journal of ClinicalEpidemiology, 54 (11), (pp. 1181-1186) (6 p.).

Zwart - van Rijkom, J.E.F., Klungel, O.H., Leufkens, H.G.M., Broekmans, A.W., Schrijver-van Velthoven, S & Umans, V.A (2001). Costs and effects of combining stenting and abciximab (ReoPro ®) in daily practice. International Journal of Cardiology, 77, (pp. 299-303) (5 p.).

Klungel, O.H., Leufkens, H.G.M., de Boer, A., Longstreth, W.T., Kaplan, R.C., Smith, N.L. & Psaty, B.M. (2001). Differences Between Primary vs Secondary Prevention Trials Regarding the STroke Protective Effect of Antihypertensive Drugs. Archives of Internal Medicine, 161.

Mantel-Teeuwisse, A K, Kloosterman, J M, Maitland-van der Zee, A H, Klungel, O H, Porsius, A J & deBoer, A (2001). Drug-Induced lipid changes - a review of the unintended effects of some commonly used drugs on serum lipid levels. Drug Safety, 24 (6), (pp. 443-56) (14 p.).

Mantel-Teeuwisse, A.K., Kloosterman, J.M.E., Maitland-van der Zee, A.H., Klungel, O.H., Porsius, A.J.& de Boer, A. (2001). Drug-Induces Lipid Changes. Drug Safety, 24 (6), (pp. 443-456) (14 p.).

Klungel, O H, Stricker, B H, Breteler, M M, Seidell, J C, Psaty, B M & de Boer, A (2001). Is drug treatment of hypertension in clinical practice as effective as in randomized controlled trials with regard to the reduction of the incidence of stroke?. Epidemiology, 12 (3), (pp. 339-344) (6 p.).

Mantel-Teeuwisse, A.K., Klungel, O.H. & de Boer, A. (2001). Lipid abnormalities induced by novel antipsychotic drugs. Drug Safety, 24 (13), (pp. 1017-1018) (2 p.).

Maitland-van der Zee, A.H., Klungel, O.H., Kloosterman, J.M.E., Seidell, J.C., Leufkens, H.G.M. & de Boer, A. (2001). The association between antihypertensive drug therapies and plasma lipid levels in the general population. Journal of Human Hypertension, 15, (pp. 701-705) (5 p.).


Klungel, O H, Kaplan, R C, Heckbert, S R, Smith, N L, Lemaitre, R N, Longstreth, W T, Leufkens, H G,de Boer, A & Psaty, B M (2000). Control of blood pressure and risk of stroke among pharmacologicallytreated hypertensive patients. Stroke, 31 (2), (pp. 420-424) (5 p.).

Klungel, O H, de Boer, A, Paes, A H, Nagelkerke, N J, Seidell, J C & Bakker, A (2000). Estimating the prevalence of hypertension corrected for the effect of within-person variability in blood pressure. Journal of Clinical Epidemiology, 53 (11), (pp. 1158-1163) (6 p.).

Klungel, O.H., Leufkens, H.G.M. & de Boer, A. (2000). Estimation of the absolute benefit of drug treatment of hypertension in the general population. Hypertension

Klungel, O H, de Boer, A, Paes, A H, Nagelkerke, N J, Seidell, J C & Bakker, A (2000). Influence of correction for within-person variability in blood pressure on the prevalence, awareness, treatment, andcontrol of hypertension. American Journal of Hypertension, 13 (1 Pt 1), (pp. 88-91) (4 p.).

Klungel, O.H., de Boer, A., Paes, A.H.P., Seidell, J.C., Nagelkerke, N.J.D. & Bakker, A. (2000). Influence of correction for within-person-variability in blood pressure on the prevalence, awareness, treatment and control of hypertension. American Journal of Hypertension, 13, (pp. 88-91) (4 p.).

Klungel, O H, de Boer, A, Paes, A H, Herings, R M, Seidell, J C & Bakker, A (2000). Influence of question structure on the recall of self-reported drug use. Journal of Clinical Epidemiology, 53 (3), (pp. 273-277) (5 p.).

Klungel, O H, Stricker, B H, Breteler, M M, Seidell, J C & de Boer, A (2000). Onderbehandeling van hypertensie en het risico op beroerte bij de oudste ouderen. Tijdschrift voor Gerontologie en Geriatrie, 31 (3), (pp. 119-122) (4 p.).

Klungel, O H, de Boer, A & Seidell, J C (2000). Overestimation of the number of individuals with hypertension who are eligible for treatment according to the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Archives of Internal Medicine, 160 (10), (pp. 1540) (1 p.).

Klungel, O.H., Leufkens, H.G.M. & de Boer, A. (2000). Prediction or assessment of the number of averted events by treatment of hypertension. British Medical Journal

Klungel, O H, Paes, A H, de Boer, A, Kuyvenhoven, M M, Seidell, J C & Bakker, A (2000). Sex differences in the medication choice for hypertension in general practice - A study with written case simulations. Pharmacy World and Science, 22 (4), (pp. 140-146) (7 p.).




Mantel-Teeuwisse, A.K., Klungel, O.H., Porsius, A.J. & de Boer, A. (2000). Cholesterolverlagers en doelmatigheid. Pharmaceutisch Weekblad, 135 (4), (pp. 108) (1 p.).

Klungel, O.H., de Boer, A. & Leufkens, H.G.M. (2000). Effectiviteit van geneesmiddelen in de dagelijkse praktijk. Conceptuur, 22, (pp. 10-11) (2 p.).

Maitland-van der Zee, A.H., Klungel, O.H., Leufkens, H.G.M. & de Boer, A. (2000). Geneesmiddeltherapie en het genotype van de patiënt. Pharmaceutisch Weekblad, 135, (pp. 378-379) (2 p.).

Klungel, O.H., Paes, A.H.P., Seidell, J.C., Kuijvenhoven, M.M. & de Boer, A. (2000). Sekseverschillen bij de medicamentueze behandeling van hypertensie door de huisarts. Huisarts en Wetenschap, 43 (7), (pp. 303-305) (3 p.).


Klungel, O H, de Boer, A, Paes, A H, Herings, R M, Seidell, J C & Bakker, A (1999). Agreement between self-reported antihypertensive drug use and pharmacy records in a population-based study in The Netherlands. Pharmacy World and Science, 21 (5), (pp. 217-220) (4 p.).

Klungel, O H, de Boer, A, Paes, A H, Seidell, J C & Bakker, A (1999). Cardiovascular diseases and risk factors in a population-based study in The Netherlands - agreement between questionnaire information and medical records. Netherlands Journal of Medicine, 55 (4), (pp. 177-83) (7 p.).

Klungel, O.H., de Boer, A., Paes, A.H.P., Seidell, J.C. & Bakker, A. (1999). Cardiovascular diseases and risk factors in a population-based study in the Netherlands: agreement between questionnaire information and medical records. Netherlands Journal of Medicine, 55, (pp. 177-183) (7 p.).

Klungel, O.H., Stricker, B.H.Ch., Paes, A.H.P., Seidell, J.C., Bakker, A., Voko, Z., Breteler, M.M.B. & deBoer, A. (1999). Excess Stroke Among Hypertensive Men and Women Attributable to Undertreatmentof Hypertension. Stroke, 30, (pp. 1312-1318) (7 p.).

Klungel, O.H., Paes, A.H.P., de Boer, A., Kuyvenhoven, M.M., Seidell, J.C. & Bakker, A. (1999). Sex differences in the medication choice for hypertension in general practice. A study written case simulations. Studies on the quality of the pharmacological treatment of hypertension in the general population.

Bouvy, M.L., Heerdink, E.R., Klungel, O.H., de Boer, A., Stuurman-Bieze, A.G.G. & Leufkens, H.G.M. (1999). Women with angina pectoris receive less antiplatelet treatment then men. British Journal of General Practice, 49, (pp. 299-300) (2 p.).


Klungel, O.H., Seidell, J.C., Paes, A.H.P. & de Boer, A. (1999). Onderbehandeling van hypertensie: voorkomen, gevolgen en determinanten. Cardiologie, 6, (pp. 556-560) (5 p.).


Klungel, O H, Seidell, J C & de Boer, A (1998). Assessment of control of hypertension in the population. Journal of Hypertension, 16 (3), (pp. 395-6) (2 p.).

Klungel, O H, Seidell, J C & de Boer, A (1998). Overestimation of the prevalence of hypertension in the population. Journal of Hypertension, 16 (11), (pp. 1702-3) (2 p.).

Klungel, O H, de Boer, A, Paes, A H, Seidell, J C & Bakker, A (1998). Sex differences in antihypertensive drug use - determinants of the choice of medication for hypertension. Journal of Hypertension, 16 (10), (pp. 1545-53) (9 p.).

Klungel, O.H., de Boer, A., Paes, A.H.P., Seidell, J.C., Nagelkerke, N.J.D. & Bakker, A. (1998). Undertreatment of hypertension in a population-based study in The Netherlands. Journal of Hypertension, 16, (pp. 1371-1378) (8 p.).


Klungel, O.H., de Boer, A., Paes, A.H.P., Seidell, J.C. & Bakker, A. (1998). Aanzienlijke onderbehandeling vrouwen aangetoond. Pharmaceutisch Weekblad, 133, (pp. 872-876) (5 p.).


Klungel, O H, de Boer, A, Paes, A H, Seidell, J C & Bakker, A (1997). Sex differences in the pharmacological treatment of hypertension - a review of population-based studies. Journal of Hypertension, 15 (6), (pp. 591-600) (10 p.).


Klungel, O.H., de Boer, A., Paes, A.H.P., Seidell, J.C. & Bakker, A. (1996). Man/vrouw verschillen in de behandeling van hypertensie: internationale trends. Tijdschrift voor sociale gezondheidszorg : TSG : 14-daags blad van de Algemene Nederlandse Vereniging voor Sociale Gezondheidszorg, 4,



(pp. 51-51) (1 p.).

Klungel, O.H., de Boer, A., Paes, A.H.P., Seidell, J.C. & Bakker, A. (1996). Onderbehandeling van hypertensie bij mannen en vrouwen: een dwarsdoorsnede populatie-onderzoek in Nederland. Tijdschrift voor sociale gezondheidszorg : TSG : 14-daags blad van de Algemene Nederlandse Vereniging voor Sociale Gezondheidszorg, 4, (pp. 26-26) (1 p.).

Projects IMI-Big data @ Heart (awarded)

IMI-Get Real (finished)

IMI-PROTECT (finished)

IMI-EU2P (ongoing)

EMA Framework contract for pharmacoepidemiological studies

Health Care Institute Netherlands collaboration

Project on lifecycle analysis of ATMPS (EFPIA funding via Lygature which a Dutch organization for public/private funding).

Memberships Professional memberships:

International Society for Pharmacoepidemiology (ISPE)

Nederlands vereniging voor Epidemiologie (VVE)

Royal Dutch Society for the Advancement of Pharmacy (KNMP)

Associate Editor Pharmacoepidemiology & Drug Safety Europe

Program committee member ICPE 2017

Other Relevant Information


Documents

PERSONAL INFORMATION Olaf Klungel INFORMATION Olaf Klungel ... European Journal of Clinical Pharmacology, 72 (9), ... Pharmacoepidemiology and Drug Safety, 25