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Performance Characteristics of a State of the ArtPreclinical PET/SPECT/CT Scanner
Nya Mehnwolo Boayue 1 Samuel Kuttner1
1Center for Diagnostic PhysicsUniversity Hospital of North-Norway
Medfys , 2016
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 1 / 11
Motivation Motivation PET subsystem SPECT subsystem CT subsystem Summary
Aim of study
NEMA NU4 for PETNo current standard for preclinical SPECT or CTLiterature Study
Lots of information in the literature but no current accepted standardNEMA NU 4 for PET but has limitations eg. Reconstruction
Develop measurement protocols and analysis methods in matlab
PET SPECT CTImage Reconstruction Signal to Noise Ratio Spatial ResolutionSpatial Resolution Spatial Resolution UniformityRecovery Coefficient Image ReconstructionSpill over Ratio SensitivitySensitivity UniformityQuantification NoiseUniformity Energy Resolution
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 2/11
Motivation Motivation PET subsystem SPECT subsystem CT subsystem Summary
Aim of study
NEMA NU4 for PET
No current standard for preclinical SPECT or CTLiterature Study
Lots of information in the literature but no current accepted standardNEMA NU 4 for PET but has limitations eg. Reconstruction
Develop measurement protocols and analysis methods in matlab
PET SPECT CTImage Reconstruction Signal to Noise Ratio Spatial ResolutionSpatial Resolution Spatial Resolution UniformityRecovery Coefficient Image ReconstructionSpill over Ratio SensitivitySensitivity UniformityQuantification NoiseUniformity Energy Resolution
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 2/11
Motivation Motivation PET subsystem SPECT subsystem CT subsystem Summary
Trifoil Imaging: Triumph II R© smallanimal PET/SPECT/CT scanner
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 3/11
PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
PET Noise and Spatial Resolution
0.25 mm 22Na point source 1.1MBq
7.4MBq 18F in a cylindrical phantom
MLEM 3D
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 4/11
PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
PET Noise and Spatial Resolution
0.25 mm 22Na point source 1.1MBq
7.4MBq 18F in a cylindrical phantom
MLEM 3D
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 4/11
PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
PET Noise and Spatial Resolution
0.25 mm 22Na point source 1.1MBq 7.4MBq 18F in a cylindrical phantom
MLEM 3D
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 4/11
PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
PET Noise and Spatial Resolution
0.25 mm 22Na point source 1.1MBq 7.4MBq 18F in a cylindrical phantom
MLEM 3D
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 4/11
PET subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
PET Recovery Coefficient and Spill over Ratio
NEMA NU4 Image QualityPhantom
RC calculation SOR calculation
RC decreases with rod diameter Spill over from hot surroundings to coldwater or air compartment due to systemPSF
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 5/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT Spatial Resolution and Sensitivity
.25mm Co-57 Point source 3.7MBq
Cylindrical phantom
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 6/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT Spatial Resolution and Sensitivity
.25mm Co-57 Point source 3.7MBq
Cylindrical phantom
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 6/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT Spatial Resolution and Sensitivity
.25mm Co-57 Point source 3.7MBq Cylindrical phantom
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 6/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT Spatial Resolution and Sensitivity
.25mm Co-57 Point source 3.7MBq Cylindrical phantom
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 6/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 7/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
EM Equivalent iterations = iterations * subsetsBrambilla et al, Ann Nucl Med. 2005Apr;19(2):75-82
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 7/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
EM Equivalent iterations = iterations * subsetsBrambilla et al, Ann Nucl Med. 2005Apr;19(2):75-82
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 7/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
EM Equivalent iterations = iterations * subsetsBrambilla et al, Ann Nucl Med. 2005Apr;19(2):75-82
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 7/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
5 iterations 8 subsets
5 iterations 8 subsets
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 8/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
EM Equivalent iterations = iterations * subsetsBrambilla et al, Ann Nucl Med. 2005Apr;19(2):75-82
5 iterations 8 subsets
5 iterations 8 subsetsNya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 8/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
EM Equivalent iterations = iterations * subsetsBrambilla et al, Ann Nucl Med. 2005Apr;19(2):75-82
5 iterations 8 subsets
5 iterations 8 subsetsNya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 8/11
SPECT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
SPECT reconstruction optimization (OSEM algorithm)
EM Equivalent iterations = iterations * subsetsBrambilla et al, Ann Nucl Med. 2005Apr;19(2):75-82
5 iterations 8 subsets
5 iterations 8 subsetsNya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 8/11
CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
CT Spatial Resolution: Materials and Methods
50µm thick tungsten wire
Kayugawa et al, Journal of Applied Clinical MedicalPhysics, Volume 14, Number 4, 2013
Favazza et al, Phys. Med. Biol. 60 (2015)8381-8397
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 9/11
CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
CT Spatial Resolution: Materials and Methods
50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical MedicalPhysics, Volume 14, Number 4, 2013
Favazza et al, Phys. Med. Biol. 60 (2015)8381-8397
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 9/11
CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
CT Spatial Resolution: Materials and Methods
50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical MedicalPhysics, Volume 14, Number 4, 2013
QRM SSP phantom: high-contrast platelet (diameter1mm, thickness 10µm)
Favazza et al, Phys. Med. Biol. 60 (2015)8381-8397
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 9/11
CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
CT Spatial Resolution: Materials and Methods
50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical MedicalPhysics, Volume 14, Number 4, 2013
QRM SSP phantom: high-contrast platelet (diameter1mm, thickness 10µm)
Favazza et al, Phys. Med. Biol. 60 (2015)8381-8397
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 9/11
CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
CT Spatial Resolution: Materials and Methods
50µm thick tungsten wire Kayugawa et al, Journal of Applied Clinical MedicalPhysics, Volume 14, Number 4, 2013
QRM SSP phantom: high-contrast platelet (diameter1mm, thickness 10µm)
Favazza et al, Phys. Med. Biol. 60 (2015)8381-8397
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 9/11
CT subsystem Motivation PET subsystem SPECT subsystem CT subsystem Summary
CT Spatial Resolution
High res. settingsMagnification 3.5×proj 1024binning 1×1voxel size 25×25×25µm3
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 10/11
Summary Motivation PET subsystem SPECT subsystem CT subsystem Summary
Summary
We have established protocols and analysis methods for preclinicalPET/SPECT/CT in agreement with published literature
PET: MLEM 3D
SPECT: OSEM 5 iterations 8 subsets
CT spatial resolution < 120µm manufacturer’s tolerance for HR scans
Outlook
NEMA NU 4NEMA NU 5 ?NEMA NU 6 ?2030 ?
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 11/11
Summary Motivation PET subsystem SPECT subsystem CT subsystem Summary
Summary
We have established protocols and analysis methods for preclinicalPET/SPECT/CT in agreement with published literature
PET: MLEM 3D
SPECT: OSEM 5 iterations 8 subsets
CT spatial resolution < 120µm manufacturer’s tolerance for HR scans
OutlookNEMA NU 4NEMA NU 5 ?NEMA NU 6 ?2030 ?
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 11/11
Motivation PET subsystem SPECT subsystem CT subsystem Summary
Nya Mehnwolo Boayue , Samuel Kuttner Preclinical PET/SPECT/CT February 10, 2016 11/11
