Perception and Memory in the Medial temporal Lobe: Insights from Anatomy

and Physiology

MDRS Chapel Hill, NC9/25/09

Wendy A. SuzukiCenter for Neural Science

New York University

Talk Outline

• Neuroanatomy of the PRC and area TE

• Physiology of the PRC and area TE

• Future experiments

Ventral View of Macaque Monkey Brain

rs

PR

ER

PHTE

24/25/32Pi

Ia

Id

Ig

Frontal Lobe Temporal Lobe InsularCortex

CingulateGyrus

ParietalLobe

V4

23/29/30

7a/LIP

STSd STG

TE

STSv

TEO

11/1246

13

DG

SubHPC

30-60%18-29%5-17%<5%

Entorhinal

ParahippocampalPerirhinal

Suzuki and Amaral, 1994

TE/TEO 63%

TF/TH 25%STSd 6%

Insula 2%Frontal lobe 2%

Cingulate/Retrosplenial <1% V4 2%

PerirhinalCortex

Cortical Inputs to the Perirhinal Cortex

Dorsal area TE

TFOrbital areas 11 and 13

V4/TEO

Area TE

Frontal area 8 and 45

Cortical Inputs to Area TE

PerirhinalParietal (LIPd)

24/25/32Pi

Ia

Id

Ig

Frontal Lobe Temporal Lobe InsularCortex

CingulateGyrus

ParietalLobe

V4

23/29/30

7a/LIP

STSd STG

TE

STSv

TEO

11/1246

13

DG

SubHPC

30-60%18-29%5-17%<5%

Entorhinal

ParahippocampalPerirhinal

Suzuki and Amaral, 1994

What about the cytoarchitectonic features of these areas?

24/25/32Pi

Ia

Id

Ig

Frontal Lobe Temporal Lobe InsularCortex

CingulateGyrus

ParietalLobe

V4

23/29/30

7a/LIP

STSd STG

TE

STSv

TEO

11/1246

13

DG

SubHPC

30-60%18-29%5-17%<5%

Entorhinal

ParahippocampalPerirhinal

Suzuki and Amaral, 1994

Talk Outline

• Neuroanatomy of the PRC and area TE

• Physiology of the PRC and area TE

• Future experiments

Pair Coding response

Naya et al., 2003

Individual cell responses in area 36

Pro

babi

lity

Cor

rect

0 10 20 30 40 500

0.2

0.4

0.6

0.8

1

Behavioral Learning Curve and Delay Activity Over Time to Scene 653

Response (S

pikes/Sec

)

-10

0

10

20

30

40

50

Baseline Activity

Trials C110600.4 Wirth et al., 2003

Early

Late Early

Late+

+ +

+

Object 1 Object 2

Place 1

Place 2

Object-Place Association Task

Wirth et al, 2009

Fixation500ms

Cue500ms

Delay700ms

Early500ms

Late500ms

Reward ITI2000ms

++ ++ ++ ++ ++

Bar Release Period

Fixation500ms

Cue500ms

Delay700ms

Early500ms

Late500ms

Reward ITI2000ms

++ ++ ++ ++ ++

Bar Release Period

Conclusions:

Pair coding neurons are built in the perirhinal cortex from the sensory input

from area TE.

Talk Outline

• Neuroanatomy of the PRC and area TE

• Physiology of the PRC and area TE

• Future experiments

Experiments?