Pediatric Hepatology School Hungary, Visegrad 2016 Program

SUMMER SCHOOL

27-30 April 2016, Visegrád, HungaryPEDIATRIC HEPATOLOGY SUMMER SCHOOL2

WELCOME

It is my great pleasure to welcome You on the

Pediatric Hepatology Summer School 2016

Visegrád. The Pediatric Hepatology Summer School

is organised by the Hepatology Committee of the

European Society for Paediatric Gastroenterology,

Hepatology and Nutrition (ESPGHAN) and supported

by the United European Gastroenterology (UEG).

The educational goal toward which the summer

school is organised is to provide an update in

knowledge on the pathophysiology, diagnosis,

treatment and prevention of the most common

liver diseases in children and, furthermore, to

provide well-founded advice on the management

of these children and on referral criteria.

During the school, lectures and presentations

are given by expert paediatric hepatologists

from various European centres and members of

the ESPGHAN Hepatology Committee. To cover

all important topics other experts (pathologist,

radiologist, paediatric surgeon) are also invited.

We hope that the limited number of participants

will give ample opportunities for discussion and

networking between participants and faculty

members.

I wish you a very pleasant and fruitful stay in Visegrád!

Antal Dezsőfi

organised by the Hepatology Committee of

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FACULTY

Ulrich Baumann, Germany

Patrizia Burra, Italy

Dominique Debray, France

Antal Dezsőfi, Hungary

Attila Doros, Hungary

Björn Fischler, Sweden

Isabel Goncalves, Portugal

Dino Hadzic, UK

Jörg Jahnel, Austria

Deirdre Kelly, UK

Alex Knisely, UK/Hungary

Zoltán Máthé, Hungary

Valério Nobili, Italy

Piotr Socha, Poland

Henkjan Verkade, Netherlands

SCIENTIFIC PROGRAM

Pediatric Hepatology Summer School 2016 Visegrád, Hungary (27-30 April 2016) has been accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. Pediatric Hepatology Summer School 2016 is designated for a maximum of, or up to 18 European CME credits (ECMEC).


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DAY 1 27 APRIL 2016

– 13.00 Arrival

13.00 – 14.00 Lunch

14.00 Welcome, opening

14.15 – 16.00 SESSION1:INTRODUCTION

14.15 – 14.40 Pediatric liver diseases in adulthood (P. Burra)

14.40 – 15.00 Liver function tests (U. Baumann)

15.00 – 15.30 Introduction to liver imaging (A. Doros)

15.30 – 16.00 Introduction to liver pathology (A. Knisely)

16.00 – 16.30 Coffee break

16.30 – 19.00 SESSION2:CHOLESTASIS

16.30 – 17.00 Novel diagnostic tools in inherited liver disease (U. Baumann)

17.00 – 17.30 Cholestatic lives diseases (H. Verkade)

17.30 – 18.00 Cholestasis: imaging (A. Doros)

18.00 – 18.30 Cholestasis: pathology (A. Knisely)

18.30 – 19.00 Cholestasis: management (J. Jahnel)

20.00 Dinner


DAY 2 28 APRIL 2016

08.30 – 10.30 SESSION3:METABOLICLIVERDISEASES

08.30 – 09.00 Metabolic liver diseases (N. Hadzic)

09.00 – 09.30 Conservative/medical management of metabolic liver diseases (P. Socha)

09.30 – 10.00 NAFLD (V. Nobili)

10.00 – 10.30 Recent advances in NAFLD treatment (V. Nobili)


11.00 – 13.00 SESSION4:IMMUNOLOGICALASPECTSOFLIVERDISEASES

11.00 – 11.30 Autoimmunity and the liver (D. Debray)

11.30 – 12.00 The liver in systemic diseases (IBD, coeliac disease, DM, Immunodeficiency) (B. Fischler)

12.00 – 12.30 New treatment options for immune mediated liver diseases. Biological therapy (D. Debray)

12.30 – 13.00 Operational tolerance (N. Hadzic)

13.00 – 14.00 Lunch

14.00 – 16.30 SESSION5:PORTALHYPERTENSION&MISC.

14.00 – 14.30 Pre-, and post hepatic portal hypertension (J. Jahnel)

14.30 – 15.00 Management of portal hypertension (A. Dezsőfi)

15.00 – 15.30 Complications of chronic liver disease (D. Debray)

15.30 – 16.00 Drug induced liver diseases (H. Verkade)


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16.00 – 16.30 Iron & the liver: Neonatal haemochromatosis versus hemosiderosis and genetic causes of iron overload (B. Fischler)


17.00 – 19.00 Interactive case presentations

20.00 Renaissance dinner

DAY 3 29 APRIL 2016

08.30 – 10.30 SESSION6:ALF&TX

08.30 – 09.00 Acute liver failure (U. Baumann)

09.00 – 09.30 Medical management of acute liver failure (I. Goncalves)

09.30 – 10.00 Principal considerations in the timing of transplantation (P. Socha)

10.00 – 10.30 Marginal indications in pediatric liver transplantation (U. Baumann)


11.00 – 13.00 SESSION7:TRANSPLANTATION

11.00 – 11.30 “Tailored” post-transplant immunosuppression? (N. Hadzic)

11.30 – 12.00 Interventional radiology (A. Doros)

12.00 – 12.30 Histopathology of acute and chronic rejection, graft hepatitis and de-novo AIH after OLT (A. Knisely)

12.30 – 13.00 Surgical complications of liver transplantation (Z. Máthé)

13.00 – 14.00 Lunch

14.00 – 17.00 Interactive case presentations

18.00 Boat excursion & Dinner


DAY 4 30 APRIL 2016

08.30 – 10.30 SESSION8:VIRALINFECTIONS&MALIGNANCIES

08.30 – 09.00 The impact of the viral infections in pediatric hepatology (B. Fischler)

09.00 – 09.30 Hepatological aspects of the pediatric oncology. Liver tumours and extrahepatic malignancies (D. Debray)

09.30 – 10.00 PTLD (A. Dezsőfi)

10.00 – 10.30 Medical management of chronic liver disease (I. Goncalves)


11.00 – 12.00 SESSION9:SCIENCE&CLINICALPRACTICE

11.00 – 11.30 Challenges of transition of pediatric liver patients to adult hepatologist (D. Kelly)

11.30 – 12.00 Why and how to read/write an abstract or a scientific paper? (H. Verkade)

Evaluation of the summer school.

12.00 Closing remarks, farewell

12.15 Lunch


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FACULTY

UlrichBaumannMD,FRCPCHProfessor of Paediatric Gastroenterology and Hepatology, Hannover Medical School, Germany

Following training in gastroenterology and hepatology in Birmingham and Essen appointment as Consultant Paediatric Hepatologist in Birmingham, UK in 2002. In 2008 return to Germany, chair in Paediatric Hepatology and Gastroenterology at Hannover Medical School. Research interests focus on metabolic liver disease, autoimmune liver disease and liver transplantation. Collaborator in the EnprEMA recognised paediatric liver transplantation network ChilSFree and the European gene therapy consortium CureCN. Elected member (2010) and chair (2013) of the ESPGHAN hepatology committee. 2014 associate editor Journal of Padiatric Gastroenterology and Nutrition (JPGN).

PatriziaBurraMD,PhDMultivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology- University Hospital of Padova, Italy

Diploma: Scientific High School „G.Marinelli”, Udine (Italy), conferred on 1977.

Medical degree: School of Medicine and Surgery, University of the Study, Padova (Italy), conferred on 1984 (110/110 with honours).

Thesis on: Alcoholic liver disease: etiomorphological study in patients from different geographical areas (Veneto, Italy-Scotland, U.K.).

Diploma of Abilitation to practice the profession of a medical doctor, University of the Study, Padova (Italy), 1984 (94/100).

Registration as Medical and Surgical Doctor Registry, Udine (Italy) since 16.1.1985 and Padova (Italy) since 26.5.1988.

Specialization on Gastroenterology and Endoscopy, School of Specialization, Padova (Italy), conferred on 6.7.1988 (70/70 with honours). Thesis on: Lipoperoxidation on alcoholic liver disease: malondialdehyde assessment.

PhD and visting fellow (1988-1991) Liver Unit and Liver Research Laboratories, Queen Elizabeth Hospital, Birmingham, United Kingdom

General Medical Conuncil registration, London between 16.3.1989 and 16.3.1992.

PhD on Hepatology, University of the Study, Padova (Italy) 1988-1993. Final degree conferred on 8.6.1993, Rome (Italy).

Senior registrar at the Gastroenterology Unit, University of the Study, Padova (Italy) from 16.8.1993 to 1995 and then Consultant on Gastroenterology from 1995 to 30.11.2001.


Assistant Professor of Gastroenterology

Academical appointment since 1.12.2001 at Padova University, Medical School, Gastroenterology, Department of Surgical and Gastrointestinal Sciences

Teaching professor, School of Specialization on Gastroenterology and Endoscopy, School of Medicine and School of PhD, University of the Study, Padova since the Academical year 1993/94

Chief of the Regional Center on Cell Therapy for the Metabolic Liver Diseases, Padova University Hospital, since 27th September 2004

Head of the Multivisceral Transplant Unit Padova, documented 31st December 2002, activated 28 July 2010

National Scientific Abilitabilitation for Professor of Gastroenterology 18 December 2013

Associate Professor of Gastroenterology

Academical appointment since 1.12.2014 at Padova University, Gastroenterology, Department of Surgery, Oncology and Gastrointerology

Vice Rector for Research Training Padova university since 1 October 2015

DominiqueDebrayMD,PhD Pediatric Hepatology Unit, Necker Hospital, Paris, France

Dr Dominique Debray received her medical degree from the University of Paris, France where she completed her residency in pediatrics. Her clinical post-doctoral training includes a fellowship in pediatric hepatology at Bicêtre University Hospital in Paris. Since 1989, she has dedicated her career to the management of pediatric chronic liver diseases including liver transplantation initially at Bicêtre hospital, and since 2010 at Necker-Enfants Malades Hospital in Paris. One of her main field of interest is Cystic Fibrosis related liver disease with ongoing clinical and basic research in this field. Dr Debray published or contributed to over 100 papers reflecting her interest in pediatric hepatology, cystic fibrosis and liver transplantation, and has been invited as an expert in pediatric hepatology and pediatric liver transplantation to give a large number of international lectures. She is an active member of the French speaking Society of Organ Transplantation (SFT), of the CF working group and hepatology committee of the European society of pediaric gastroenterology hepatology and nutrition (ESPGHAN).


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AntalDezsőfiMD,PhDFirst Department of Pediatrics, Semmelweis University, Budapest, Hungary

Antal Dezsofi is a pediatric gastroenterologist and hepatologist at the First Dept. of Pediatrics, Semmelweis University Budapest. He received his M.D. from Semmelweis Medical University. Beside the general pediatric clinical work his interest turned to pediatric gastrointestinal endoscopy and became pediatric gastroenterologist in 2003. Later on he focused on pediatric liver diseases, his main interest are the follow up of liver transplanted children and immune mediated liver diseases. Currently he is the head of the Hepatology at First Department of Pediatrics, Semmelweis University, Budapest. He is a member of the Hepatology Committee of ESPGHAN.

AttilaDorosMD,PhDSemmelweis University, Department of Transplantation and Surgery, Budapest, Hungary

Attila Doros MD, PhD, is 50 years old, radiologist and interventional radiologist at Semmelweis University, Dept. of Transplantation and Surgery. His main interest is non vascular intervention and interventional oncology but busy as a diagnostician too. Consultant in the field of vascular, abdominal and chest CT, vascular, abdominal, head-and-neck and superficial ultrasound, including contrast enhanced examination and in the field of MR examinations of the liver. Concerning pediatric patients he has some experience performing interventions in the liver and treating complications after liver and kidney transplantation. He is a senior lecturer and postgraduate teacher of radiology. Most of his publications are connected to clinical experience with transplantation.

BjörnFischlerMD,PhDDepartment of Pediatrics, CLINTEC, Karolinska University Hospital, Stockholm, Sweden

Björn Fischler is specialist in Paediatrics and currently works as senior consultant in hepatology at Karolinska University Children’s Hospital within the department of Paediatric Gastroenterology, Hepatology and Nutrition. He defended his PhD thesis on neonatal cholestasis in 1998, his current research concerns paediatric cholestatic liver disease and viral hepatitis.

Medical degree (MD), Karolinska Institute, Stockholm, 1987

Medical license, 1990

Specialist in Paediatrics, 1994

Assoc. Professor, Paediatrics, 2003


DinoHadzicMD,MScPaediatric Centre for Hepatology, Gastroenterology and Nutrition, King’s College Hospital, London, UK

Professor Hadzic has been of the leading paediatric hepatologists at King’s College Hospital, London since 1994. His main clinical research interests are biliary atresia, alpha-1 antitrypsin deficiency, primary immune deficiencies, liver transplantation and liver-based metabolic conditions. His publication record includes more than 150 articles and reviews in international journals and 20 textbook chapters. He is a frequent invited speaker at conferences worldwide. His editorial activities include premier international paediatric and hepatology journals.

IsabelGoncalvesMD Pediatric Liver Unit / UTHPA, CHUC, Coimbra, Portugal

2011 – 2014 Pediatric Hepatology & Liver Transplant/ UTH-PA(CHUC), Surgery department, Pediatric Hospital Coimbra (HPC), Portugal

Qualifications:

1993 – 1994 Post-graduation on Liver Transplant, Brussels Saint Luc University Hospital, UCL, Belgium

1992 - 1993 Basic Training in GI, Nutrition and Hepatology (equivalent to Specialty registrar) Pediatric Hospital Coimbra (HPC), Portugal

Memberships/Societies:

2011 – 2016 International Pediatric Transplant Association (IPTA)

1996 – 2016 European Society for Pediatric Gastroenterology, Hepatology & Nutrition (ESPGHAN).

1992 – 2016 Pediatric Portuguese Society (SPP)

1993 -- 2016 Portuguese Pediatric Society of Gastroenterology, Hepatology and Nutrition (SPGP). Chair of the Society since 2014.

JörgJahnelMD Paediatric Gastroenterology, Hepatology and Rheumatology, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria

Dr Jörg Jahnel is specialist in Pediatrics and works at the Medical University of Graz, Department of Pediatrics. He is interested in pediatric gastroenterology, hepatology and rheumatology and is currently the head of a general pediatric ward. His current research concerns bile acids, paediatric cholestatic liver disease and antibodies to biologicals. He is trainee member of the Hepatology Committee (2014-17) and of the Trainee Committee of ESPGHAN (2013-16).


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DeirdreKellyMDLiver Unit, Birmingham Children’s Hospital, Birmingham, UK

Professor Deirdre Kelly is Professor of Paediatric Hepatology at the University of Birmingham, Consultant Paediatric Hepatologist and Founding Director of the Liver Unit for Birmingham Children’s Hospital NHS Foundation Trust. She is a graduate of Trinity College, Dublin.

She has trained in both adult and paediatric gastroenterology and hepatology. She set up the Paediatric Liver Unit at Birmingham Children’s Hospital in 1989 which provides a national and international service for children with liver failure and undergoing liver transplantation, transforming survival and outcome for these children. Until 2008, the Unit was the only national unit to be designated for small bowel and liver transplantation in the UK.

Professor Kelly runs an active research programme focusing on viral hepatitis in children, molecular genetics of inherited liver disease, quality and outcome of life following liver and/or intestinal transplantation. She is on the Council of the General Medical Council (2013-) and is a Non-Executive Director of the Health Research Authority (2014-). She was a Commissioner on the Care Quality Commission (2008-2013) and Healthcare Commission (2007- 2009).

She was Medical Director of the Children’s Hospital (2000-2007). She has been President of the European Society of Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) (2006-2010), British Society for Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) (2004-2007) and the International Paediatric Transplant Association (IPTA) (2002-2005).

Professor Kelly has recently been made a CBE (Commander of the British Empire) by her Majesty the Queen.

Professor Kelly is author of several textbooks about paediatric liver disease and has published many original articles and chapters on liver disease, liver transplantation and viral hepatitis.

AlexKniselyMDInstitute of Pathology, Medical University Graz, Graz, Austria

Medical training in United States; there developing an interest in liver histopathology, in particular cholestasis, that led to work in London (King’s College Hospital) for some fifteen years; recently retired to part-time work in Graz (Austria) and part-time retirement in Körmend (Hungary).


ZoltánMáthéMD,PhD Semmelweis University, Department of Transplantation and Surgery, Budapest, Hungary

Institution: Transplantation and Surgical Department of Semmelweis University Budapest

Present status: Head of the Department, Associate Professor of Surgery

Medical school: 1987-1994 – Semmelweis University of Medicine, Budapest, Hungary; Hungarian National Medical Examination, Doctor of Medicine(1994)

Doctoral thesis: Malignancies after kidney transplantation – 1994, Semmelweis Univ., grade: excellent

Postgraduate training: 1994 - 1999 – resident in general surgery at Semmelweis University, Dept. of Transplantation and Surgery, Budapest, Hungary – Practical course of Advanced – Hepatobiliary Laparoscopic Surgery, 2000 May, Surgitrain, Pécs, Hungary

Specialisation: Hungarian National Board Exam of General Surgery, Nov. 1999, Budapest, grade: excellent

European Board Exam: Transplantation Surgery: UEMS-EBS Exam, Modules 1,2,3,4 given by Europen Board of Surgery, Prague, Sept. 30th., 2007.Hepato-Pancreato-Biliary Surgery, 2009, Bruxelles

PhD THESIS: Factors Influencing the Early Results of Pancreatic Islet Transplantation: Studies on Enzymes and Islet Revascularisation defended in Oct. 9th, 2007 at Semmelweis University Budapest, Hungary, grade: excellent

Special interests: Transplantation and Hepato- Pancreato-Biliary Surgery, Travel, outdoor sports and literature

ValérioNobiliMDHepato-metabolic Unit, Bambino Gesu Children’s Hospital, Roma, Italy

Born in Milan on 10/04/1966

Actually, he is the Head of Hepatometabolic Liver Disease section and the Chief of Liver Research Unit at the Bambino Gesù Children Hospital in Rome, Italy

He is a member of the Hepatology Committee of the ESPGHAN (European Society Gastro Hepatology Nutrition Pediaric) and member of the Board of MEDSCAPE Gastroenterology.

He is reviewer for the following medical Journal: Hepatology, GUT, Journal Gastroenterology and Hepatology, Journal Pediatric Gastroenterology and Nutrition, World Journal Gastroenterology, Journal of Hepatology, Liver International, Pediatric Transplantation, Expert Review of Molecular Diagnostics, Journal of Hematology, Journal of Internal Medicine, Journal of Clinical Rheumatology, Clinical Endocrinology. For the Pediatric Obesity Journal he’s an Associate Editor

He has published more than 300 works in international reviews and he has attended many national and international Congresses as reporter.


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PiotrSochaMD Department of Gastroenterology, Hepatology and Nutritional Disorders. The Children’s Memorial Health Institute Warsaw, Poland

Piotr Socha is a Professor of Pediatrics & Gastroenterology in the Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics in the The Children’ s Memorial Health Insitute (CMHI) in Warsaw which is the referral hospital for Poland.

His research and clinical work were mainly devoted to cholestatic liver disease, non-alcoholic fatty liver disease, rare metabolic liver diseases (eg. Wilson disease, newly described PGM-1), nutrition in hepatology and gastroenterology (eg. LCPUFA deficiency), obesity prevention and therapy, feeding disorders, protracted diarrhoea of infancy and early childhood.

Piotr Socha was the chair of the Hepatology Committee of ESPGHAN (2010-2013) and he was appointed Scientific Secretary of ESPGHAN in 2015. Piotr Socha contributs/contributed to 7 EU projects (CHOP, EUROWILSON, EARNEST, PERFECT, NUTRIMENTHE, TOYBOX, EARLY NUTRITION). He is the president of the Polish Society for Pediatric Gastroenterology, Hepatology and Nutrition. He published over 300 peer reviewed papers (101 indexed in pubmed) and contributed to 32 book chapters.

HenkjanVerkadeMD,PhDPediatric Gastroenterology/Hepatology Department of Pediatrics, Beatrix Children’s Hospital, University Medical Center Groningen, The Netherlands

Dr. Henkjan J. Verkade is a pediatric gastro/hepatologist at the Beatrix Children’s Hospital of the University Medical Center Groningen. He studied medicine at the Erasmus University Rotterdam. He received his PhD degree in Medicine cum laude at the University of Groningen on the thesis entitled „Lipid absorption and metabolism”. Henkjan Verkade was a post-doctoral fellow with Dennis E. Vance of the Lipid and Lipoprotein Research Group of the University of Alberta, Edmonton, Canada. His post-doc studies concentrated on assembly and secretion of Very Low Density Lipoproteins by the liver. Henkjan Verkade combines clinical work in pediatric gastro/hepatology with clinical and fundamental research projects. He is a member of the Hepatology Committee, European Society Pediatric Gastroenterology Hepatology and Nutrition. His current research projects involve intestinal lipid absorption and metabolism, pediatric liver disease and transplantation, and early life programming of long-term health. He has (co-)authored >150 peer-reviewed publications in the fields pediatrics, hepatology, and gastro-intestinal physiology, and > 15 book chapters.


SOCIAL PROGRAM

27 APRIL 2016 – DINNER IN SIRÁLY RESTAURANT

The quarter century old restaurant of excellent reputation with its stylish interior is located in the center of Visegrád featuring a terrace with a view of the Danube.

28 APRIL 2016 – RENAISSANCE DINNER

Visegrád’s golden age came at the end of the 15th century, under the reign of King Matthias, when his italian wife Beatrice helped bringing masters from her country to renew the Royal Palace and the Castle in the renaissance style.

Program: Departure from the hotel at 7:30 pm, guided tour in Royal Castle Palace taking group photo, dinner with beverages in the Renaissance Restaurant.

29 APRIL 2016 – DINNER AND BOAT EXCURSION

Enjoy a 3-hour long boat trip from Visegrád to the Danube Bend – an excursion into Hungary’s history. Have an unforgettable tour with delicious dinner and Hungarian wines

Program: Departure from the hotel at 6:00 pm.


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NOTES


PEDIATRICHEPATOLOGY SUMMER SCHOOL

ORGANISED BY THE HEPATOLOGY COMMITTEE OF

27-30 April 2016

🌎 pedhepaschool2016.misandbos.hu

✉ [email protected]

Hotel Visegrád, Visegrád, Hungary

Local Organiser

Antal Dezsőfi MD, PhDFirst Dept. of Pediatrics Semmelweis University

Budapest, Hungary


Congress bureau

Mis & Bos Ltd Emese Veres

H-1149 Budapest, Pillangó park 7. fszt. 1-2.


SUMMER SCHOOL

Documents

Pediatric Hepatology School Hungary, Visegrad 2016 Program