MINGGU VI

MITOKONDRIA

MITOKONDRIA

FUNGSI MITOKONDRIA

HUMAN NUCLEAR

MITOCHONDRIAL GENOMES

NUCLEAR GENOME MITOCHONDRIAL

GENOME

Size 3200 Mb 166 kb

No of different

DNA molecules

23 (in XX cells) or 24

(in XY cells) all linear

One circular DNA

molecule

Total no of DNA

molecules per cell

46 in diploid cells but

varies according to

ploidy

Often several

thousands (but variable

Associated protein Several classes of

histone amp nonhistone

protein

Largely free of protein

No of genes ~ 30 000 ~35-000 37

Gene density ~ 1100 kb 1045 kb

Mitochondrial DNA mutations in human genetic

disease (Wallace Sci Amer 27740)

An affected woman transmits the trait to

all her children Affected men

(represented by squares do not pass

the trait to any of their offspring

Maternal genetic

transmission

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

MITOKONDRIA

FUNGSI MITOKONDRIA

HUMAN NUCLEAR

MITOCHONDRIAL GENOMES

NUCLEAR GENOME MITOCHONDRIAL

GENOME

Size 3200 Mb 166 kb

No of different

DNA molecules

23 (in XX cells) or 24

(in XY cells) all linear

One circular DNA

molecule

Total no of DNA

molecules per cell

46 in diploid cells but

varies according to

ploidy

Often several

thousands (but variable

Associated protein Several classes of

histone amp nonhistone

protein

Largely free of protein

No of genes ~ 30 000 ~35-000 37

Gene density ~ 1100 kb 1045 kb

Mitochondrial DNA mutations in human genetic

disease (Wallace Sci Amer 27740)

An affected woman transmits the trait to

all her children Affected men

(represented by squares do not pass

the trait to any of their offspring

Maternal genetic

transmission

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

FUNGSI MITOKONDRIA

HUMAN NUCLEAR

MITOCHONDRIAL GENOMES

NUCLEAR GENOME MITOCHONDRIAL

GENOME

Size 3200 Mb 166 kb

No of different

DNA molecules

23 (in XX cells) or 24

(in XY cells) all linear

One circular DNA

molecule

Total no of DNA

molecules per cell

46 in diploid cells but

varies according to

ploidy

Often several

thousands (but variable

Associated protein Several classes of

histone amp nonhistone

protein

Largely free of protein

No of genes ~ 30 000 ~35-000 37

Gene density ~ 1100 kb 1045 kb

Mitochondrial DNA mutations in human genetic

disease (Wallace Sci Amer 27740)

An affected woman transmits the trait to

all her children Affected men

(represented by squares do not pass

the trait to any of their offspring

Maternal genetic

transmission

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

HUMAN NUCLEAR

MITOCHONDRIAL GENOMES

NUCLEAR GENOME MITOCHONDRIAL

GENOME

Size 3200 Mb 166 kb

No of different

DNA molecules

23 (in XX cells) or 24

(in XY cells) all linear

One circular DNA

molecule

Total no of DNA

molecules per cell

46 in diploid cells but

varies according to

ploidy

Often several

thousands (but variable

Associated protein Several classes of

histone amp nonhistone

protein

Largely free of protein

No of genes ~ 30 000 ~35-000 37

Gene density ~ 1100 kb 1045 kb

Mitochondrial DNA mutations in human genetic

disease (Wallace Sci Amer 27740)

An affected woman transmits the trait to

all her children Affected men

(represented by squares do not pass

the trait to any of their offspring

Maternal genetic

transmission

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

Mitochondrial DNA mutations in human genetic

disease (Wallace Sci Amer 27740)

An affected woman transmits the trait to

all her children Affected men

(represented by squares do not pass

the trait to any of their offspring

Maternal genetic

transmission

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

An affected woman transmits the trait to

all her children Affected men

(represented by squares do not pass

the trait to any of their offspring

Maternal genetic

transmission

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

Mitochondrial DNA polymorphisms track human

Migrations (Wallace Sci Amer 27740)

All humans descend from a small group of Africans

This group originated in central Africa ~200000 years ago

The founding group was small (102-104 people)

Descendants of this group replaced all other hominids everywhere in the world

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

JALUR INTRINSIK APOPTOSIS

Small protein found

loosely associated

with the inner

membrane of the

mitochondrion

electron transport

chain

Caspase = cysteine-aspartic

proteases

YANG HARUS DIPERHATIKAN

SAAT MENCARI ARTIKEL DI INTERNET

bull TIDAK BOLEH DARI

-httpwww com

-Blog httpblogspot http wordpress

-Wikipedia

bull MENCARI DI SEARCH ENGINE (MISALNYA Google)

bull keyword dlm bahasa inggris misalnya ldquoRibosome

disease disorderrdquo

bull berikan ldquopdfrdquo pada keyword (Ribosome disease pdf)

bull setelah menemukan artikel ndash di download dan diprint

(utk lampiran pd makalah)

YANG HARUS DIPERHATIKAN

SAAT MENCARI ARTIKEL DI INTERNET

bull TIDAK BOLEH DARI

-httpwww com

-Blog httpblogspot http wordpress

-Wikipedia

bull MENCARI DI SEARCH ENGINE (MISALNYA Google)

bull keyword dlm bahasa inggris misalnya ldquoRibosome

disease disorderrdquo

bull berikan ldquopdfrdquo pada keyword (Ribosome disease pdf)

bull setelah menemukan artikel ndash di download dan diprint

(utk lampiran pd makalah)