1
RESULTS: After a median follow-up of 25.2 mo., 9.7% (29/300) of men exhibited stress incontinence (SUI). Fifteen (45/300) percent of all patients had type II DM and 28% (83/300) were obese or greater. The 3 variables independently predictive of SUI in multivariate analysis were age (mean: 60.3 in incontinent men vs. 57.4 yrs, p<0.04) (Odds ratio (OR):3.25, 95% Condence Intervals (CI): 1.45 to 7.31), BMI (28.9 vs. 27.5, p<0.05) (OR:2.09, 95% CI:1.02 to 4.73), and a history of DM (31% of men with SUI had DM vs. 12.3%, p<0.03) (OR:2.59, 95% CI:1.07 to 6.31). The risk of SUI increased linearly both with BMI: (BMI<30: 8.8%, BMI 30 to 34.5: 12.7%; BMI 35 to 39.9: 22.2%, and BMI ¡Ý40: 33.3%) and age: (age 50: 2.3%, age 51 to 60: 6.8%, age 61 to 70: 16%, and age 71: 25%) (p< 0.05). Diabetic patients exhibited a 20% risk of SUI compared with 7.8% in non-diabetics (p<0.03), even in patients with a BMI 25 (42.9% with DM vs. 4.1%, p< 0.003). No other variables adversely affected SUI including PSA, prostate weight, operative time, blood loss, anastomotic leak, nerve sparing status, history of hypertension, or smoking. CONCLUSIONS: Puerto Rican patients undergoing RP have twice the incidence of DM than the US population and a high rate of obesity. While Puerto Rican men who underwent RP who were not diabetic, had a BMI< 30 and were younger than 61 years had a SUI rate of 3.4%, this increased to 14.5% with a BMI30, 16.3% when older than 60 years, and beyond 20% with DM even in the absence of obesity. These are important data to discuss with patients in order to establish realistic expectations. Source of Funding: none PD11-08 PATIENT PERCEPTION OF PHYSICAL AND EMOTIONAL DISTRESS RELATED TO URODYNAMICS TESTING AT THE UNIVERSITY OF MICHIGAN; A QUESTIONNAIRE-BASED STUDY AMONG MEN AND WOMEN WITH AND WITHOUT NEUROLOGIC CONDITIONS Anne M. Suskind*, J. Quentin Clemens, John T. Stoffel, Ann Oldendorf, Bahaa S. Malaeb, Teresa Jandron, Anne P. Cameron, Ann Arbor, MI INTRODUCTION AND OBJECTIVES: Urodynamic testing is an invasive procedure that can be associated with physical discomfort and emotional distress. The purpose of this study was to identify patientsperceptions of this test according to gender and neurologic status. METHODS: This is a questionnaire-based pilot study completed by patients immediately after undergoing urodynamic testing. Partici- pants were asked questions pertaining to their perceptions of physical and emotional distress related to the study, their urologic and general health history, and their demographics. Results were stratied by gender and the presence of neurologic conditions. RESULTS: A total of 108 patients completed the questionnaire. The majority of respondents (62.0%) felt that the exam was neither physically nor emotionally distressing, and 31.0% felt that the physical distress was worse than the emotional distress (Table). The worst part of the physical discomfort was the placement of the urethral catheter (36.8% in males, 35.1% in females). Pain associated with placement of the rectal catheter was low in both groups (7.9% in males and 3.9% in females). Results stratied by the presence of neurologic conditions followed a similar pattern; however, respondents with neurologic conditions reported no physical discomfort more often (40.7% compared to 29.7% in non-neurologic respondents). In terms of emotional distress, most respondents reported no emotional distress associated with the urodynamics study (51.5%), followed by anxiety (24.2%), embarrassment (16.2%), and not understanding what was happening (2.0%). Results were similar regardless of gender or the presence of a neurologic condition. CONCLUSIONS: Urodynamic studies are well tolerated by men and women both with and without neurologic conditions. Patient perception of physical discomfort tended to be worse than that of emotional discomfort, with placement of the urethral catheter causing the most physical distress. Patient reported perceptions of physical and emotional distress stratified by gender and neurologic status. Results are presented as percentages. Overall (N¼108) Male (N¼39) Female (N¼60) Non-Neuro (N¼80) Neuro (N¼28) WORST PART OF EXAM Physical discomfort 31.0 31.6 30.4 32.9 25.9 Emotional discomfort 5.0 5.3 5.4 4.1 7.4 Equally bad 2.0 2.6 1.8 1.4 3.7 Neither bad 62.0 60.5 62.5 61.6 63.0 PHYSICAL DISCOMFORT Placement of urethral catheter 35.6 36.8 35.1 39.2 25.9 No discomfort 32.7 31.6 31.6 29.7 40.7 Holding a full bladder 10.9 7.9 14.0 10.8 11.1 Urinating 6.9 2.6 10.5 6.8 7.4 Placement of catheter in rectum 5.0 7.9 3.5 5.4 3.7 Filling bladder with uid 3.0 2.6 1.8 2.7 3.7 EMOTIONAL DISCOMFORT None 51.5 47.4 54.6 50.0 55.6 Anxiety 24.2 26.3 23.6 25.0 22.2 Embarrassment 16.2 18.4 14.6 16.7 14.8 Not understanding what was happening 2.0 2.6 3.6 2.8 7.4 Fear 2.0 2.6 1.8 2.8 Source of Funding: none PD11-09 NEW APPROACH FOR THE MEASUREMENT OF QUANTITATIVE ELECTROMYOGRAPHY OF THE EXTERNAL URETHRAL SPHINCTER AND CORRELATION WITH URINARY SYMPTOMS AND PROSTATE MORPHOLOGY Giovanni La Croce*, Matteo Ferrari, Lucerne, Switzerland; Francesca Bianchi, Marco Cursi, Andrea Salonia, Milan, Italy; Cristophe Germann, Lucerne, Switzerland; Giancarlo Comi, Ubaldo Del Carro, Milan, Italy; Hansjorg Danuser, Agostino Mattei, Lucerne, Switzerland INTRODUCTION AND OBJECTIVES: Aim of the present study was to investigate external urethral sphincter (EUS) activity by quanti- tative electromyography (EMG) using a new approach and assess correlations with urinary symptoms and prostate-related magnetic resonance imaging (MRI) parameters. METHODS: 58 men submitted to transrectal ultrasound-guided (TRUS) prostate biopsy had a computer-assisted EMG [Motor Unit Potential (MUP) and Interference Pattern (IP) analysis] of EUS by using transperineal approach in lithotomy position. EMG needle positioning was driven by oscilloscopic, acoustic and TRUS guidance. Clinical data including body mass index (BMI), Charlson Comorbidity Index (CCI), ICS-male SF, IPSS, and I-QoL questionnaires were collected for each patient; prostate volume and membranous urethral length were measured in prostate cancer patients submitted to MRI-staging (n ¼ 17). Linear correlation test (Spearman) was used to investigate corre- lations between clinical variables and EUS-EMG parameters. On the other hand regression models tested the dependence of clinical pa- rameters on repressors IPfreq IPamp. RESULTS: The preliminary analysis of 20 consecutive signals for each MUP and IP parameters from the right and left EUS-side showed in all patients no signicant differences or trends and compa- rable results supporting the use of the mean value. Throughout the sample, the means for MUPs parameters were: duration 6.91 ms, amplitude 411.2164.2 ìV, phases 3.60.7, turns 2.10.6. For IP: amplitude/turns 308.271.8 ìV, number of turns/s 232.5154.1 Hz and amplitude/turn divided by turns/s 1.42.1. No signicant correlation Vol. 191, No. 4S, Supplement, Sunday, May 18, 2014 THE JOURNAL OF UROLOGY â e289

PD11-08 PATIENT PERCEPTION OF PHYSICAL AND EMOTIONAL DISTRESS RELATED TO URODYNAMICS TESTING AT THE UNIVERSITY OF MICHIGAN; A QUESTIONNAIRE-BASED STUDY AMONG MEN AND WOMEN WITH AND

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Page 1: PD11-08 PATIENT PERCEPTION OF PHYSICAL AND EMOTIONAL DISTRESS RELATED TO URODYNAMICS TESTING AT THE UNIVERSITY OF MICHIGAN; A QUESTIONNAIRE-BASED STUDY AMONG MEN AND WOMEN WITH AND

Vol. 191, No. 4S, Supplement, Sunday, May 18, 2014 THE JOURNAL OF UROLOGY� e289

RESULTS: After a median follow-up of 25.2 mo., 9.7% (29/300)of men exhibited stress incontinence (SUI). Fifteen (45/300) percent ofall patients had type II DM and 28% (83/300) were obese or greater.The 3 variables independently predictive of SUI in multivariate analysiswere age (mean: 60.3 in incontinent men vs. 57.4 yrs, p<0.04) (Oddsratio (OR):3.25, 95% Confidence Intervals (CI): 1.45 to 7.31), BMI (28.9vs. 27.5, p<0.05) (OR:2.09, 95% CI:1.02 to 4.73), and a history of DM(31% of men with SUI had DM vs. 12.3%, p<0.03) (OR:2.59, 95%CI:1.07 to 6.31). The risk of SUI increased linearly both with BMI:(BMI<30: 8.8%, BMI 30 to 34.5: 12.7%; BMI 35 to 39.9: 22.2%, and BMI¡Ý40: 33.3%) and age: (age � 50: 2.3%, age 51 to 60: 6.8%, age 61 to70: 16%, and age � 71: 25%) (p< 0.05). Diabetic patients exhibited a20% risk of SUI compared with 7.8% in non-diabetics (p<0.03), even inpatients with a BMI �25 (42.9% with DM vs. 4.1%, p< 0.003). No othervariables adversely affected SUI including PSA, prostate weight,operative time, blood loss, anastomotic leak, nerve sparing status,history of hypertension, or smoking.

CONCLUSIONS: Puerto Rican patients undergoing RP havetwice the incidence of DM than the US population and a high rate ofobesity. While Puerto Rican men who underwent RP who were notdiabetic, had a BMI< 30 and were younger than 61 years had a SUI rateof 3.4%, this increased to 14.5% with a BMI�30, 16.3% when older than60 years, and beyond 20% with DM even in the absence of obesity.These are important data to discuss with patients in order to establishrealistic expectations.

Source of Funding: none

PD11-08PATIENT PERCEPTION OF PHYSICAL AND EMOTIONALDISTRESS RELATED TO URODYNAMICS TESTING AT THEUNIVERSITY OF MICHIGAN; A QUESTIONNAIRE-BASED STUDYAMONG MEN AND WOMEN WITH AND WITHOUT NEUROLOGICCONDITIONS

Anne M. Suskind*, J. Quentin Clemens, John T. Stoffel, Ann Oldendorf,Bahaa S. Malaeb, Teresa Jandron, Anne P. Cameron, Ann Arbor, MI

INTRODUCTION AND OBJECTIVES: Urodynamic testing is aninvasive procedure that can be associated with physical discomfort andemotional distress. The purpose of this study was to identify patients’perceptions of this test according to gender and neurologic status.

METHODS: This is a questionnaire-based pilot study completedby patients immediately after undergoing urodynamic testing. Partici-pants were asked questions pertaining to their perceptions of physicaland emotional distress related to the study, their urologic and generalhealth history, and their demographics. Results were stratified by genderand the presence of neurologic conditions.

RESULTS: A total of 108 patients completed the questionnaire.The majority of respondents (62.0%) felt that the exam was neitherphysically nor emotionally distressing, and 31.0% felt that the physicaldistress was worse than the emotional distress (Table). The worst partof the physical discomfort was the placement of the urethral catheter(36.8% in males, 35.1% in females). Pain associated with placement ofthe rectal catheter was low in both groups (7.9% in males and 3.9% infemales). Results stratified by the presence of neurologic conditionsfollowed a similar pattern; however, respondents with neurologicconditions reported no physical discomfort more often (40.7%compared to 29.7% in non-neurologic respondents). In terms ofemotional distress, most respondents reported no emotional distressassociated with the urodynamics study (51.5%), followed by anxiety(24.2%), embarrassment (16.2%), and not understanding what washappening (2.0%). Results were similar regardless of gender or thepresence of a neurologic condition.

CONCLUSIONS: Urodynamic studies are well tolerated by menand women both with and without neurologic conditions. Patientperception of physical discomfort tended to be worse than that ofemotional discomfort, with placement of the urethral catheter causingthe most physical distress.

Patient reported perceptions of physical and emotional distress stratified bygender and neurologic status. Results are presented as percentages.

Overall(N¼108)

Male(N¼39)

Female(N¼60)

Non-Neuro(N¼80)

Neuro(N¼28)

WORST PART OFEXAM

Physical discomfort

31.0 31.6 30.4 32.9 25.9

Emotional discomfort

5.0 5.3 5.4 4.1 7.4

Equally bad

2.0 2.6 1.8 1.4 3.7

Neither bad

62.0 60.5 62.5 61.6 63.0

PHYSICALDISCOMFORT

Placement of urethralcatheter

35.6

36.8 35.1 39.2 25.9

No discomfort

32.7 31.6 31.6 29.7 40.7

Holding a full bladder

10.9 7.9 14.0 10.8 11.1

Urinating

6.9 2.6 10.5 6.8 7.4

Placement of catheter inrectum

5.0

7.9 3.5 5.4 3.7

Filling bladder with fluid

3.0 2.6 1.8 2.7 3.7

EMOTIONALDISCOMFORT

None

51.5 47.4 54.6 50.0 55.6

Anxiety

24.2 26.3 23.6 25.0 22.2

Embarrassment

16.2 18.4 14.6 16.7 14.8

Not understanding whatwas happening

2.0

2.6 3.6 2.8 7.4

Fear

2.0 2.6 1.8 2.8 –

Source of Funding: none

PD11-09NEW APPROACH FOR THE MEASUREMENT OF QUANTITATIVEELECTROMYOGRAPHY OF THE EXTERNAL URETHRALSPHINCTER AND CORRELATION WITH URINARY SYMPTOMSAND PROSTATE MORPHOLOGY

Giovanni La Croce*, Matteo Ferrari, Lucerne, Switzerland;Francesca Bianchi, Marco Cursi, Andrea Salonia, Milan, Italy;Cristophe Germann, Lucerne, Switzerland; Giancarlo Comi,Ubaldo Del Carro, Milan, Italy; Hansj€org Danuser, Agostino Mattei,Lucerne, Switzerland

INTRODUCTION AND OBJECTIVES: Aim of the present studywas to investigate external urethral sphincter (EUS) activity by quanti-tative electromyography (EMG) using a new approach and assesscorrelations with urinary symptoms and prostate-related magneticresonance imaging (MRI) parameters.

METHODS: 58 men submitted to transrectal ultrasound-guided(TRUS) prostate biopsy had a computer-assisted EMG [Motor UnitPotential (MUP) and Interference Pattern (IP) analysis] of EUS by usingtransperineal approach in lithotomy position. EMG needle positioningwas driven by oscilloscopic, acoustic and TRUS guidance. Clinical dataincluding body mass index (BMI), Charlson Comorbidity Index (CCI),ICS-male SF, IPSS, and I-QoL questionnaires were collected for eachpatient; prostate volume and membranous urethral length weremeasured in prostate cancer patients submitted to MRI-staging (n ¼17). Linear correlation test (Spearman) was used to investigate corre-lations between clinical variables and EUS-EMG parameters. On theother hand regression models tested the dependence of clinical pa-rameters on repressors IPfreq IPamp.

RESULTS: The preliminary analysis of 20 consecutive signalsfor each MUP and IP parameters from the right and left EUS-sideshowed in all patients no significant differences or trends and compa-rable results supporting the use of the mean value. Throughout thesample, the means for MUPs parameters were: duration 6.9�1 ms,amplitude 411.2�164.2 ìV, phases 3.6�0.7, turns 2.1�0.6. For IP:amplitude/turns 308.2�71.8 ìV, number of turns/s 232.5�154.1 Hz andamplitude/turn divided by turns/s 1.4�2.1. No significant correlation