PATHOPHYSIOLOGY – BIO 345

Course Designation: BIO 345 – Spring 2019 Time: Tuesday & Thursday 1:15 – 2:30 Course Location: Masterton Hall, Room 113 Instructor: David E. Harris, Ph.D. Office Location: Masterton Hall, Room 325 E-mail: DEHARRIS@MAINE.EDU Phone : 228-8178Office Hours: Tuesdays 10:00 – 11:30

Thursdays 10:00 – 11:30Other times at mutual convenience

Required Text: Essentials of Pathophysiology, 4th editionCarol Porth

What To Expect: Pathophysiology is the study of how normal body function is altered by disease. Most of the people in this class have had a recent (or not so recent) course in Anatomy & Physiology. This should provide an excellent background in the basic form and function of the normal body. In this course we will explore normal function in greater detail and go on to discuss abnormalities in function caused by disease. We will begin by discussing some general concepts of pathophysiology and will then focus on genetic diseases, cancer, immune disturbances, cardiovascular disease, respiratory disease, GI disease, renal disease, hepato-biliary disease, and endocrine disease (including diabetes).

Course Website: I have established a website for this course on the university “Blackboard” system. This site will contain a variety of information (most of it under “Content”) that you will definitely need including homework assignments, PowerPoint notes, and additional course documents.

Accommodations: If you need course adaptations or accommodations because of a disability, please make an appointment to see me as soon as possible. Assistance is available through Disabilities Services Center, 242 Luther Bonney Hall, Portland campus. You can call them at 780-4706 to arrange an appointment with the Coordinator of DSC.

Title IX statement: The University of Southern Maine is committed to making our campuses safer places for students. Because of this commitment, and our federal obligations, faculty and other employees are considered mandated reporters when it comes to experiences of interpersonal violence (sexual assault, sexual harassment, dating or domestic violence, and stalking). Disclosures of interpersonal violence must be passed along to the University’s Deputy Title IX Coordinator who can help provide support and academic remedies for students who have been impacted. More information can be found online at http://usm.maine.edu/campus-safety-project or by contacting Sarah E. Holmes at sarah.e.holmes1@maine.edu or 207-780-5767. If students want to speak with someone confidentially, the following resources are available on and off campus: University Counseling Services (207-780-4050); 24 Hour Sexual Assault Hotline (1-800-871-7741); 24 Hour Domestic Violence Hotline (1-866-834-4357).

Keeping up: It is vital that you keep. For this reason I have a homework assignment for each chapter. These are available under the “Content” section of Blackboard. The due dates are on the course timeline on the last page of this syllabus. You are expected to complete these assignments on-line.

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The purpose of these homework assignments is 3 fold: 1) They encourage you to keep up. Some of the questions may not be complex (although some

are). However, you do need to spend some time with the material to answer them correctly. 2) They give you some very good ideas about what I may focus on for the exam. In this regard, try

to think as broadly as possible. If I ask a question about 1 aspect of a complex process, you should immediately realize that I want you to know about the entire process, not just that 1 aspect.

3) They give you some practice in answering the sorts of questions that I ask. Every professor has a slightly different testing style. These questions will give you some experience with mine before you’re faced with an in-class closed-book exam.

Academic honesty: Academic honesty is of the utmost importance in all classes because it maintains the integrity of the entire educational process. Plagiarism, cheating, and falsification of information are violations of academic integrity that will not be tolerated in this class. Please check the USM Office of Community Standards website for official definitions of these practices. For a more information about academic honesty please become familiar with the USM Student Academic Integrity Policy. You can also get a copy of the policy through the Office of Student Judicial Affairs. If you are in doubt concerning the requirements, please consult me before you complete any assignment so that I can give you “a read” on what is/ is not acceptable. Attendance policy: This is an upper-level class so I don’t take attendance. However, I think it is fair to say that the path to success begins with good attendance. We cover A LOT of material in every class, and if you miss a class it is your responsibility to get caught up. I can help you with this, but there’s no substitute for being there! Distractions: As with all classes, please turn you cell phones off and PUT THEM AWAY! There is significant evidence that even the presence of a face-down turned off cell phone can distract you; its use will distract you and the people around you. Feel free to use laptops during class as long as you are using them for class-related activities. Also, feel free to record the class is this will help you learn. Drop/ Incomplete Policy: USM establishes the policy for grading when a student drops a course. A student may receive a grade of W if s/he withdraws before 60% of the course is completed. This semester that means that you may drop and receive a W up to March 28th. A grade of “W” has no effect on the GPA. After that time, the grade is “F.” It is important that students understand that this is a University policy. I cannot give grades of “W” to students who leave a class after the set date no matter how much I may wish to. I do, of course, understand that circumstances beyond the control of a student (for example, health or family emergencies) may arise late in the semester and that these circumstances may make it impossible for a student to complete a course. If you are passing this course and an emergency arises that makes it impossible for you to finish, please contact me to discuss a grade of “Incomplete.” I will consider requests for an incomplete when: 1) a legitimate emergency exists, 2) the student is passing at the time of the request, and 3) the student has a realistic plan to complete the course work by the end of the following semester. On-line Course Evaluations: USM is now using an Electronic Course Evaluation (ECE) system and this course is included in the project. During the last week of classes, students will receive an email notice that asks you to complete your course evaluation online. This email will include a direct link to the course evaluation, and you will log-in by using your Mainestreet ID and password. Your ratings on the evaluation would be very useful to your instructor if you answer thoughtfully and honestly. The

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responses you give are confidential and will be collected by the Office of Academic Assessment. After the final grades are posted, your instructor will receive a summary report of the student responses. All student feedback is valued and is being used for course and program improvement purposes. Thanks, in advance, for your participation. Prerequisites: This is an upper level science course. The prerequisite is Anatomy & Physiology (two semesters). If you have any questions about your preparation for this course, please come see me. If you are concerned that your background may be a bit weak, I can recommend some excellent materials to review/ enhance you knowledge of normal physiology. Textbook: There is one required textbook for this class (Porth). It’s absolutely mandatory that you have a copy of this text AND THAT YOU READ IT! Course Objectives: This course will:

1) expand your understanding of normal body function, and to use this understating as the basis for gaining an appreciation of the physiological basis for some important diseases.

2) provide a basic understanding of how the body reacts to disease and compensates for some important diseases, and

3) explore the physiological basis for the treatment of some important diseases. Additional Learning Outcomes: This class has also been approved as part of a suite of courses that meet the USM general education requirement for Science Exploration. This suite of courses also includes the 2-semeser A&P sequence and Health Related Research. The learning outcomes for this gen ed requirement that will be met by this course are that students will be able to:

articulate the boundaries of science and how science differs from other disciplines both in content and methodology including how scientists create knowledge of natural processes through scientific methods

discuss the relevance of science in their lives and how it may affect them in their public and private roles

understand and be able to use the vocabulary and concepts of the science, building science literacy regarding natural processes in the world

use quantitative reasoning skills in the solution of science problems

discuss the strengths and the limitations of the sciences, and recognize that scientists differ in their interpretations of data

demonstrate skills of effective communication and analysis How To Succeed:

1) Read the syllabus carefully. There’s a lot of important material here that will help you succeed and answer some of the more obvious questions.

2) Keep up with the course content. Look carefully at the PowerPoints. Take notes. READ THE TEXT. 3) Do not get behind on the homeworks. These may not take a lot of time to complete, but they do

force you to keep up. 4) Be totally sure that you can answer the review questions before taking the exam. 5) Contact me by email or in person if you have questions. 6) If you need extra help, ask me.

Evaluations: I understand that a poor grade can be a major disappointment to a student. Thus I have

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designed the evaluation procedure to encourage students to keep up with the material and to give the maximum opportunity for success. I have also designed a range of evaluation tool formats to provide equal opportunities for success to people with a range of learning styles.

1) Homework: There will be homework assignments due for each chapter that cover the material that you will have learned for that chapter. You will complete these assignments on line. The purpose of these assignments is to encourage you to keep up, to telegraph what topics I am likely to ask about on an exam, and to give you some practice with my testing style. Together these assignments count for 25% of the final grade. You may keep these assignments “open” for as long as you like to work on them, but once you hit “submit” your answers are final. These will be available until the morning that the next class session starts.

I understand that it is possible to download these homeworks with the answers and that some people have done so in previous semesters. (I do re-use some homework questions.) This raises the possibility that some students will get the homework questions with the answers and simply mark the correct answer when they complete the assignments. That will give the student a good grade but will not contribute to her/his learning. It is also unfair to students who honestly try to complete these assignments on their own. To minimize the impact of this sort of behavior, I will give full (100%) credit on the homeworks to anyone who averages 75% or better on the homeworks through the semester. For those who get below 75% I will use their average as the homework grade.

2) Exams: These will be 3 “hour exams.” Together, these will each count for 75% of the final grade. Please show up on time for exams. Students entering the room late while an exam is in progress distract their classmates.

Late Work & Make-up Exams:

1) No late assignments will be accepted or makeup exams given without a VERY good excuse! 2) Late homework that is accepted will be marked down at the rate of 10 points/ week late. 3) No homework assignments will be accepted after the exam for that section of the course. 4) If you do have a legitimate emergency & cannot make an exam I can give a makeup (almost

always within 1 week of the original exam date). However, you MUST let me know prior to the scheduled exam time that you need a makeup exam and make arrangements with me to come to my office to take it.

Grading Scheme: Here’s how I translate the number grades on my spreadsheet into the letter grades that appear on your transcript:

Grade Points

A 93 and above

A- 90-92

B+ 87-89

B 83-86

B- 80-82

C+ 77-79

C 73-76

C- 70-72

D+ 67-69

D 60-66

F below 60

Copyright 2019 David E. Harris, Ph.D.

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Please note that Blackboard does not weight the grades for different assignments. Thus you cannot just divide the total points by the number of assignments to get your course average. To compute your course average, begin by averaging your homework grades. If you got > 75% then you count that as 100. Add the 100 for the homework to the sum of the 3 exam grades and divide by 4. Then round to the closest whole number. Inclement Weather Policy: If we miss class time due to inclement weather I will probably need to make it up by doing “voice overs” to the slides we were scheduled to cover that day. If we miss an exam day, we will hold the exam on the next regularly scheduled class day. If we miss the final, plan to take the exam on the Saturday following finals week. FAQs What do I do if I get stumped by the technology? Call the USM computer help desk (780-4029) or visit them on the 1st floor of Luther Bonney Hall. You should also let me know that you’re having trouble (by email preferably). I May be able to help. For instance, if you can’t access one of the documents, I could email it to you. What do I do if I get stumped by the material?

1) Email me with your question. 2) Bring your question to class & ask it there.

How do I complete homework assignments & get the corrected versions back?

1) Go to the “Homeworks” file under “Content” on the Blackboard site. 2) Click on the assignment icon. 3) Complete the assignment taking as long as you want (up to the due date). 4) Hit “submit” to submit your final answers. 5) You should be able to get your grade, as well as review your answers and the correct answers

immediately. 6) All homeworks are “due” at 8:00 on the day stated in the syllabus schedule.

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Course Timeline: Readings, Assignments, & Exams Date Chapter Topic 1/22/19 Review syllabus Chapter 2: Cell response to stress (Start) 1/24/19 Chapter 2: Cell response to stress (Finish) Chapter 4 Cell proliferation & tissue repair 1/29/19 Homework due: Chapters 2 & 4

Chapter 6 Genetic & congenital diseases (Start) 1/31/19 Chapter 6 Genetic & congenital diseases (Finish) 2/5/19 Homework due: Chapter 6

Chapter 7 Neoplasia (Start) 2/7/19 Chapter 7 Neoplasia (Finish) 2/12/19 Homework due: Chapter 7 Chapter 8 Fluid, electrolyte & acid-base balance (Start) 2/14/19 Chapter 8 Fluid, electrolyte & acid-base balance (Finish) 2/19/19 Homework due: Chapter 8 & ABGs assignment Exam # 1: Chapters 2, 4, 6, 7, & 8 2/21/19 Chapter 15 Normal immune function 2/26/19 Homework due: Chapter 15 Chapter 16 Disorders of immune response (Start) 2/28/19 Chapter 16 Disorders of immune response (Finish) 3/5//19 Homework due: Chapter 16

Chapter 18 Disorders of blood flow & pressure (Start) 3/7/19 Chapter 18 Disorders of blood flow & pressure (Finish) 3/12/19 Homework due: Chapter 18

Chapter 19 Disorders of cardiac function (Start) 3/14/19 Chapter 19 Disorders of cardiac function (Finish) 3/26/19 Homework due: Chapter 19

Chapter 20 Heart failure & shock (Start) 3/28/19 Chapter 20 Heart failure & shock (Finish)

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4/2/19 Exam # 2 Chapters 15, 16, 18, 19, & 20 Homework due: Chapter 20 4/4/19 Chapter 26 Kidney disease 4/9/19 Homework due: Chapter 26

Chapter 23 Disorders of ventilation & gas exchange (Start)

4/11/19 Chapter 23 Disorders of ventilation & gas exchange (Finish) 4/16/19 Homework due: Chapter 23 Chapter 29 Disorders of GI function 4/18/19 Homework due: Chapter 29

Chapter 30 Hepatobiliary disorders

4/23/19 Homework due: Chapter 30 Chapter 32 Endocrine disorders (Start) 4/25/19 Chapter 32 Endocrine disorders (Finish) 4/30/19 Homework due: Chapters 32

Chapter 33 Diabetes mellitus (Start)

5/2/19 Chapter 33 Diabetes mellitus (Finish) 5/7/19 Homework due: Chapter 33 1:30 – 3:30 Exam 3 Chapters 23, 26, 29, 30, 32, & 33

Copyright 2019 David E. Harris, Ph.D.

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