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Overview : Innate Immune Response. Receptors Detect Infection. Toll-like Receptors. Toll-like Receptors. Signal Transduction. Signal Transduction. Ubiquity of Innate Immunity. Review: Cells of the Immune System. Leukocytes – White blood cells - PowerPoint PPT Presentation
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Overview:
InnateImmune Response
Receptors Detect Infection
Toll-like Receptors
Toll-like Receptors
Signal Transduction
Signal Transduction
Ubiquity of Innate Immunity
Review: Cells of the Immune SystemLeukocytes – White blood cells
Myelocytes –macrophage, neutrophil, eosinophil,basophil
Lymphocytes – B, T and NK cells
From Larsson and Karlsson (2005)
Review: Myelocytes•Macrophages – phagocytes, antigen presenting cells (APCs), specialized cells different organs, secrete cytokines, produce complement proteins, can produce ROS/RNS.
•Neutrophils – phagoctyes, can produce ROS/RNS, secrete antimicrobial peptides, 1st cell type to migrate from blood to infections, main targets are bacteria and fungi
•Eosinophils – phagocyte, targets parasites
•Basophils – secrete cytokines, involved in allergic response
• B cells – naïve B cells: contain antigen binding receptor (or membrane bound antibody), once activated –
memory cells: provides memory of antigen/antibody interaction; plasma cells: secrete soluble antibody
Review: Lymphocytes
• T cells - contain antigen binding receptor (TCR)TH cells: secretes cytokines that activate B cells, TC cells,
macrophages and others.TC cells: eliminates altered/damaged self cells (particularly
those infected by viruses), fights tumors cells, secrete cytotoxins.Treg cells: helps suppress immune response, plays a role in
tolerance.
Review: Lymphocytes
T reg cell
•Natural killer cells – distinct from T and B cells due to lack of an antigen binding receptor, similar in function to TC cells, macrophage activation, defense against viruses, fight tumor formation, secrete cytotoxins.
Review: Cells of the Immune System
Derived from both lymphoid and myeloid precursors
•Dendritic cells – phagoctyes, antigen presenting cells (APCs), can produce ROS, secrete proinflammatory cytokines, secrete antimicrobial peptides.
Review: Cells of the Immune System
Review: Organs of the Immune SystemPrimary and secondary lymphoid organs:
1°- maturation of lymphocytes
2°- sites where mature lymphocytes interact with antigen.
Level of organization:
collection of cells vs.
lymphoid follicle
Review: Innate and adaptive immunity
Review: Innate Immune Response