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3-11-2017 Naam presentatie 1 Relative dosimetry for scanned pencil beam proton therapy Petra Trnková Outline Relative dosimetry: Integral depth dose measurements Phase space definition NCS subcommittee for proton therapy 7 th NCS Lustrum, 27.10.2017, Amsterdam

Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

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Page 1: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 1

Relative dosimetry for scanned pencil beam proton therapyPetra Trnková

Outline

• Relative dosimetry:• Integral depth dose measurements

• Phase space definition

• NCS subcommittee for proton therapy

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 2: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 2

Beam modelling of PBS PT

Integral depth dose curves

Lateral dose profile

Absolute dose

Gillin et al, Med Phys 2010

7th NCS Lustrum, 27.10.2017, Amsterdam

Integral depth dose curves

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 3: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 3

Integral depth dose curves

Pedroni et al, PMB 2015

7th NCS Lustrum, 27.10.2017, Amsterdam

Measurement setup

Fippel and Soukup, Med Phys 2004

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 4: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 4

Measurement setup

Courtesy of Ethan Cascio and Martijn Engelsman

7th NCS Lustrum, 27.10.2017, Amsterdam

Measurement setup

Courtesy of Carles Gomà

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 5: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 5

Bragg peak chambers

PTW Bragg Peak Chamber 34070

Diameter 8.16 cm

IBA Stingray

Diameter 12 cm

7th NCS Lustrum, 27.10.2017, Amsterdam

Nuclear halo

Gottschalk et al, PMB 2015

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 6: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 6

Absolute measurement of the entire halo

Gottschalk et al, PMB 2015

7th NCS Lustrum, 27.10.2017, Amsterdam

TPS modelling

Courtesy of Carles Gomà

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 7: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 7

Differences in the IDDs

Gottschalk et al, PMB 2015 Bäumer et al, J App Clin Med Phys 2015

7th NCS Lustrum, 27.10.2017, Amsterdam

Courtesy of Stefano Lorentini

Corrected IDDs (blue) vs. NOT corrected IDDs (red)

Range (mm)

IDD

(%

)

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 8: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 8

How to correct?

• Monte Carlo simulations (Fippel& Soukup, Med Phys 2004)

• Analytical calculations (Pedroni, PMB 2005)

• Experimental correction (Anand, MedPhys 2012)

• Golden beam data approach (Classie, PMB 2012)

• Create large Bragg peak chambers

• Note: RayStation 6 corrects during the beam modelling

7th NCS Lustrum, 27.10.2017, Amsterdam

Other measurement devices

• Multi-layer ionization chambers (MLIC)• IBA Zebra: 180 independent chambers

• IBA Giraffe: 180 independent chamber

• De.Tec.Tor Cube: max 128 independent chambers

• Water column with a reference and measurement chamber• PTW Peakfinder: scanning range 35 cm

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 9: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 9

MLIC

IBA Zebra: Ø 2.5 cm

IBA Giraffe: Ø 8.16 cm

De.Tec.Tor CUBE: 12.7 x 12.7 cm2

7th NCS Lustrum, 27.10.2017, Amsterdam

PTW Peakfinder

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 10: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 10

Phase space definition

7th NCS Lustrum, 27.10.2017, Amsterdam

Lateral dose profile

Gillin et al, Med Phys 2010

Parodi et al, PMB 2010

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 11: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 11

Measurement setup

CCD

Scintillatingscreen

Mirror

7th NCS Lustrum, 27.10.2017, Amsterdam

Scintillation screens

IBA Lynx Logos Systems

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 12: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 12

Spot maps

7th NCS Lustrum, 27.10.2017, Amsterdam

Angular and spatial dose distribution

Courtesy of Carles Gomà

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 13: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 13

Angular and spatial dose distribution

z1

7th NCS Lustrum, 27.10.2017, Amsterdam

Angular and spatial dose distribution

z2

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 14: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 14

Angular and spatial dose distribution

z3

7th NCS Lustrum, 27.10.2017, Amsterdam

FWHM in-air

Lin et al, PMB 2013

7th NCS Lustrum, 27.10.2017, Amsterdam

Safai et al, Transl Cancer Research 2012

Page 15: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 15

FWHM in water

7th NCS Lustrum, 27.10.2017, Amsterdam

Lin et al, PMB 2013

Spot symmetry and ellipticity

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 16: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 16

Alternative devices

• Films

• Strip chambers

• Silicon detectors

7th NCS Lustrum, 27.10.2017, Amsterdam

NCS subcommittee for proton therapy

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 17: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 17

NCS subcommittee for proton therapy

• http://radiationdosimetry.org/ncs/protontherapy

• First meeting: 5.9.2016

• Topics to be covered:• Reference dosimetry

• Single pencil beam specific characteristics

• Time and space dependent dosimetry

• Neutron contamination

• Characteristics of the dosimetry equipment

7th NCS Lustrum, 27.10.2017, Amsterdam

MembersJacco de Pooter (VSL, representative NCS board)

Carles Gomà (UZ Leuven)

Steven Habraken (ErasmusMC)

Arturs Meijers (UMCG, secretary)

Severine Rossomme (UC Louvain)

Marco Schippers (UMCG / PSI, advisor)

Enrica Seravalli (UMCU)

Petra Trnková (HollandPTC, chair)

Paul van Beers (HollandPTC)

Marc-Jan van Goethem (UMCG)

Frank Verhaegen (MAASTRO)

Gloria Vilches Freixas (MAASTRO)

7th NCS Lustrum, 27.10.2017, Amsterdam

Page 18: Outline - Radiation Dosimetry · •De.Tec.Tor Cube: max 128 independent chambers •Water column with a reference and measurement chamber •PTW Peakfinder: scanning range 35 cm

3-11-2017

Naam presentatie 18

Thank you for your attention!

7th NCS Lustrum, 27.10.2017, Amsterdam