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GATHERING WITH IPAI NATIONAL CONGGRES
(JAKARTA-APRIL 7th
2007)Budhi Sant!" #$ (#%di&a' Cn!u'tant PT Ot!u*a Indn%!ia)
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R%+'a&%
#aintain
R%+ai
A$n%&ma' '%ss )IT* 3&d
spa+e*On,%in, '%ss* septi+ andH-p%.%'emi+ s/%+
I12 u&ine
A+id $ase*e'e+t&%'-te im$a'an+es
BASIC PRINCIPLESBASIC PRINCIPLES
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Ratina' 4uid th%a+5(nut&iti%n supp%&t* dai'- 4ate& 5 e'e+t&%'-te
&e6ui&ements#
AB
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Internal data: NCE, West Java Peripheral Hospitals
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77
• !%&&e+t timin,
• !%&&e+t indi+ati%ns* d%sa,e• !%&&e+t p&%du+t (+%mp%siti%n*+%n+ent&ati%n#
• Tai'%&ed t% patient8s 9uid and
e'e+t&%'-te status* n%t dia,n%sis• )%%d m%nit%&in,
• !%st:e;e+ti.e
Rati%na' F'uid Re,imen
DN $o%o et al. &'K()
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Kua'ita! Inu! P'a.tt'%
• Ste&i'
•
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Softbag Hanya membandingkan Suhu pd sterilisasi akhir
Penyediaan air
demineralisata
121-140 oC
peralatan dan fasilitas produksi(Saturated Pure Steam) 121 oC
Bahan baku dengan
beban mikroba
dan endotoksin
(pirogen)
tidak melebihi batas
yang ditetapkan iltrasi dengan
filter
0!22 mikron
Pembuatan botol" pengisian danpenutupan botol
dengan Blo# moulding" dilakukanpada suhu 1$% oC &
Proses sterilisasi akhir dari
kemasan dan isi di otoklaf pada
suhu
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Korea Otsuka
Dong- Otsuka
Otsuka International Asia Arab Division
China Otsuka
!ai"an Otsuka
King Car Otsuka
Otsuka Philippines#K Otsuka
$uang Dong
Otsuka
!hai Otsuka
Otsuka Pakistan
%gypt Otsuka
E6+t t 8&unti%! 9i/i "
Sa,a"Tna "PNG
E6+t t 8 n%aa A!ia-Pa!i:*
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Rin,e&'atat
Ase&in,
"e@t&%seG
Na!' 07BG
N:" ")a
=AEN C
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TERAPI CAIRAN
RES3SITASI
KOLOI$KOLOI$ N3TRISIN3TRISI
Menggantikan
kehilangan akut
cairan tubuh
O!&'!() - * +
Memelihara
keseimbangan
cairan tubuh
dan nutrisi
K-%) 1 +
K-%) +
K-%) +
K-%) . +
K-%) . +
/0P(%) +
/0)O%*- 33 +
P)- /0) $ +
K-%) /$ +
/(!O& 13 +
R3#ATAN
KRISTALOI$KRISTALOI$ ELEKTROLITELEKTROLIT
&%(0)$ +
Otsu- (* +
Otsu- )& +
Repai&=!'*
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J%ni! 'autan %'%*t'it .%da!a*antni!ita!n5a
PlasmaPlasma Larutan elektrolit
isotonik
Larutan elektrolit
isotonik
Larutan elektrolit
Hipotonik
Larutan elektrolit
Hipotonik
Normal
saline
Ringer
asetat/ laktatKAEN 3B
290 308 273
278278
D5
290278
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A!%in" RL ; NSA!%in" RL ; NS
L
J00 m'
00 m'
S5* hi+'%,i* $ia% d%nan d%hida!i .% #untah-,untah h%.at $SS P%daahan
Lu*a Ba*a
K%dauatan .%dah
Inta+%ati
IN$IKASI
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Pasien Rawat Ina!Interna, Pediatric, Pulmonologi,
Cardiology, Obgyn, Neurologi
Stroke!
Post "erati#e!Surgery pts, Obgyn pts,
$%6t!a ;KAEN
$%6t!a ;KAEN
L
m'
J m'
IN$IKASI
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RES3SITASIRES3SITASI R3#ATANR3#ATAN
TERAPI CAIRAN I=
Infus Nat&ium K C00 mE62 atau %'%id 0:30 m',>am :3 2C0:C menit
Nat&ium &enda/
C (misa' , @C0@C0C @ Lm'>a
00 m'L >am
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(inger4s
a5etate +
®
Ringer’s acetate
First Lin
Fluid R suscitation Th rapyASERING
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NS, "L, Asering,
Colloids
"#$,"L#$,
"%#$,#&%%
KAEN3B
KAEN$%3
NaCl'(
NaHCO'
&lu )*(,+*(annitol
A&'te rela&ement
rehydrate,
restore perfusion!
aintenance
"epair
correct e-treme.
symptomatic electrolyte
derangement
F'uid T/e&ap-
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•Rin%>! 'a&tat%
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2A!TATE P&ima&i'- in t/e 'i.e&* and t% 'esse& de,&eet/e idne-* 'a+tate is meta$%'ied t% p-&u.ate* 4/i+/is t/en +%n.e&ted t% !O and HO (J0G# %& ,'u+%se
(0G#* and &e,ene&ati%n %f $i+a&$%nateC
A!ETATE meta$%'ied main'- in mus+'es and t% a
'esse& e@tent in tissues su+/ as idne-* /ea&t and 'i.e&
%cetate / H/00000000 %cetyl0Co%
Coen1yme %
Carbonic acid 00000000 bicarbonate
hydro*en sour+e
2reb3s cycle
"ef4 54"ose 6#4 Clinical Physiology of %cid06ase and 7lectrolyte #isorders4 c&ra80Hill +th ed 599+ p $$+
)4 a-8ell H, 2leeman C", Narins "&4 Clinical #isorders of :luid and 7lectrolyte etabolism4ac&ra80Hill 59;< +th edition p 5*='
LR &,+a% t ASERING@
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() *"DI+$ ,AK-A- . A-I
C#C#6O#7COO)a 8 CO2 8#2O )a#CO 8 C#C#6O#7COO# 6 *aktat 7
C#C#6O#7COO# 8 O2 CO2 8 #2O 9 !C Cy5le
2) *"DI+$ A*E-A- . "-"-
C#COO)a 8 CO2 8#2O
C#COO# 8 2 O2 2 CO2 8 2 #2O 9 !C Cy5le
)a#CO 8 C#COO# 6 setat 7
$*'kO&
$*0KO$%)$ - - P*- *K!!
P0('!
*D#
setil Ko
sintetase
&%!! setil - Ko
2 CO2 !C Cy5le #2O
#ETABOLIS#E ASERING@
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Na 2a+tateNa 2a+tate
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C2
#
O2
- 8 2O2
CO2
8 #2
O 8 #CO
-
6 5etate 7 6bi5arbonate7
C#:O- 8 O2 2CO2 8 2#2O 8 #CO
-
6 *a5tate 7 6bi5arbonate7
LACTATE =S ASERING@LACTATE =S ASERING@
(mus+'e#
(2i.e
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C7 SHO!= SYN"ROMESC7 SHO!= SYN"ROMES
In s/%+ states su+/ as septi+ s/%+* tissue
/-p%@ia and impai&ed /epati+ ,'u+% ne%,enesisand %@idati%n e'e.ate p'asma 'a+tate $- app&%@7L00G AR ma- $e $ette& a'te&nati.e t% 2R
In s/%+ states su+/ as septi+ s/%+* tissue
/-p%@ia and impai&ed /epati+ ,'u+% ne%,enesisand %@idati%n e'e.ate p'asma 'a+tate $- app&%@7L00G AR ma- $e $ette& a'te&nati.e t% 2R
olfe RR, Mller -I +ardo/as+ular and 0eta%ol+ responsesdurn* %urn sho+1 n the *unea p*. A0 2 Physol #3456!7#83!9834
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2 HEPATIC INS399ICIENC 2 HEPATIC INS399ICIENC
• AR .s 2R du&in, indu+ed /epati+ insu+ien+- in&a$$its7
• Hepati+ a&te&-* p%&ta' .ein and $i'e du+t 4e&e
'i,ated and .esse's 4e&e +'amp f%& 0 minutes7• AR %& 2R administe&ed 4it/in t/at 0 minutes7
• In 2R ,&%up G &edu+ti%n in ATP and a :f%'d in+&easein AMP
• !%n+'usi%n in /epati+ insu+ien+-* ,'u+%ne%,enesis isin/i$ited and t/e 'i.e& fai's t% meta$%'ie 'a+tate
• AR .s 2R du&in, indu+ed /epati+ insu+ien+- in&a$$its7
• Hepati+ a&te&-* p%&ta' .ein and $i'e du+t 4e&e
'i,ated and .esse's 4e&e +'amp f%& 0 minutes7• AR %& 2R administe&ed 4it/in t/at 0 minutes7
• In 2R ,&%up G &edu+ti%n in ATP and a :f%'d in+&easein AMP
• !%n+'usi%n in /epati+ insu+ien+-* ,'u+%ne%,enesis isin/i$ited and t/e 'i.e& fai's t% meta$%'ie 'a+tate
Na1atan :, et al. E;e+ts of Rn*er o++luson n ra%%ts. transplantaton #33?6?3&4(3?!9?4
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Masui 599$ #ec>++5)!?5=$+0=*
Naa-ama M* =a4ana S* Yamau+/i M* Tsu+/ida H*I4asaiH*Namii AUti'it- %f a+etated Rin,e& s%'uti%n asint&a%pe&ati.e 9uids du&in, /epate+t%m-7
Hem%d-nami+s* meta$%'ism* $'%%d ,asand &ena' 5 'i.e& fun+ti%ns7 T4ent- patientsC m',/& 4it/ t/e Q&st 00 m' and
t/e&eafte& &edu+ed t% C0 m',/&7
D Inta+%ati% 9'uid duin H%+at%&t,5
AR i t ti 4 id i
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0
5
(0
(5
20
25
30
35
10
15
50
Ringers la&tate
Ringers a&etate
Nakayama , 2a8ana S, @amauchi , Asuchida H, I8asaki H, Namiki %Btility of acetated
"inger solution as intraoperatiDe fluids during hepatectomyE, asui 599$ #ec>++5)!?5=$+0=*
Lactate LeDelmg.dl!
Lactate leDel at the end of operation!
+;4= / 5=4+
)945 / 5+4'
n F )*
AR a! inta+%ati% 4uid inh%+at%&t,5
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J Clin Anesth 1998 Fe!1"#1$:%&'(
2ashimoto S, et alC,+aati% %%&t! Rin%F! a&%tat% and 'a&tat% !'utin! ninta+%ati% &%nta' and +%i+h%a' t%,+%atu%!
P%AI7NAS? =* %S% physical status I and II patients undergoing
general surgery4
INA7"G7NAIONS? :ollo8ing induction 8ith $ mg.kg of thiamylal
and *45 mg.kg of Decuronium, patients 8ere randomly assigned to one
of four groups 5$ patients per group!4
Ahey receiDed inhalation anesthetics ==( nitrous o-ide BN)OE and
54*( to )4*( isoflurane or 54'( to )4=( seDoflurane! and L" or %"
Ee&t on 4ore -emerat're
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-mani& $em6rane -emerat're
p*4*$
Ee&t on 4ore -emerat're
temperature of tympanic membrane!
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!%mpa&ati.e E;e+ts %f Rin,e&8s A+etate (Ase&in,#
and Rin,e&8s 2a+tate %n +%&e tempe&atu&e and t/ef&e6uen+- %f s/i.e&in, in +esa&ean Se+ti%n unde&
Su$a&a+/n%id Anest/esia
Susi'% !/and&aEdd- Ha&i>ant%
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Stud- &esu'ts !%&e Tempe&atu&e
#inut%! Rin%>! 'a&atat% Rin%>! a&%tat% Sini:&an&% (+)
(Asering)
B%% SAB D
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!%n+'usi%n
C7 Rin,e&8s A+etate (A!%in# maintains +%&etempe&atu&e $ette& t/an Rin,e&8s 'a+tate inp&e,nant 4%men unde&,%in, +esa&eanse+ti%n unde& su$a&a+/n%id anest/esia*
si,niQ+ant'- %n t/* 0t/* t/* Lt/ minutes
7 A't/%u,/ t/e&e is n% si,niQ+ant di;e&en+ein t/e se.e&it- %f s/i.e&in, $et4een t/e
t4% ,&%ups* Rin,e&8s 'a+tate is ass%+iated4it/ ea&'ie& %++u&&en+e %f s/i.e&in, t/anA!%in
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asui 5999 Sep>+;9!?9 combined sinal an ei'ral
25 ml/kg/r A)etated *in+ers solution is etter than
la)tated *in+ers solution in rapid in-usion
e-ore )esarean se)tion e)ause o- the
)orre)tion o- neonatal la)ti) a)idosis4
"6stetri& +se
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P&ee+'ampsiaE+'ampsia
• A!%in #SO8 20
• #SO8(8 .'u!? ,%nit) /a,• Ju,'ah &aian inu! ?00-2000 ,'28 /a,
• Bi'a t%da+at hi+'%,ia .%i*an $%6tan80M ?00 ,'28/a,
• Pantau /u,'ah uin (N D0 ,'/a,)
/g&O. 23; artinya
dalam 133 ml ada 23 g=adi 1 ampul 2: ml
berisi : g
'ntuk drip 1 amp
dilarutkan dalam :33
ml sering
+sama Salha and ,ames , alker
.anagement options9 /odern management of e5lampsia
Postgrad! .ed! ,!" eb 1/// % $ - $2!
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ASERING@ in a+ute st&%e
patients
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%naesthesia 599+ Sep>+99!?
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%nesthesiology )*** NoD>9'$!?55
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D > A m%?@*
)a8 > 1:. m%?@*
Cl- > 1:. m%?@*
&0D > 3 m%?@*1 liter 1 liter
PLAS#A NaC' 0PLAS#A NaC' 0
&0D 9 A
Plasma NaCl 0.9%
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2 liter
ASI$OSIS HIPERKLORE#IK AKIBATASI$OSIS HIPERKLORE#IK AKIBAT
PE#BERIAN LAR3TAN NaC' 0PE#BERIAN LAR3TAN NaC' 0
<
&0D 9 1B&0D 9 1B sidosissidosis
)a8 > 61.381:.7@2 m%?@*> 1. m%?@*
Cl- > 61328 1:.7@2 m%?@*> 12A m%?@*
&0D > 1B m%?@*
Plasma
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D> A m%?@*
Cation8 > 1 m%?@*
Cl- > 13B m%?@*
setat- > 2A m%?@*
&0D > 3 m%?@*
1 liter 1 liter
PLAS#A Lautan ASERINGPLAS#A Lautan ASERING@@
&0D 9 A&0D 9 A
Plasma Ringer asetatAsetat cepatdimetabolisme
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2 liter
<
N,a' +H !%t%'ah +%,.%ianN,a' +H !%t%'ah +%,.%ianASERINGASERING@@
&0D 9 . lebih alkalosis 6dianggap )7
dibandingkan pemberian )aCl 3B;
)a8 > 61.3817@2 m%?@*> 1B m%?@*
Cl- > 61328 13B7@2 m%?@* > 13: m%?@*
setat- 6termetabolisme7 > 3 m%?@*
&0D > . m%?@*
Plasma
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%cta %naesthesiol Scand 599' Oct>'
2uitunen %, et al4 Hydro-yethyl starch as a prime for cardiopulmonary bypass?
effects of t8o different solutions on haemostasis4
:orty0fiDe patients undergoing coronary bypass grafting 8ere prospectiDely randomised to
three groups and receiDed in a double0blind manner as their CP6 prime either )* ml4kg05
LJ0H7S 8 5)*,***!, )* ml4kg05 HJ0H7S 8 +**,***! or "ingerKs acetate )*** ml4
Ahe final Dolume of the prime 8as completed to )*** ml 8ith "ingerKs acetate in the H7S groups4
%naesthesia and CP6 management 8ere standardised4 Plasma leDels of Don Jillebrand factor
antigen and factor GIII procoagulant actiDity 8ere significantly more depressed after CP6 in
both H7S0groups as compared 8ith the crystalloid prime group4 In addition, %PAA 8as more
prolonged and the ma-imal amplitude of thromboelastographic tracing 8as more decreased in the H7S0groups4
It is concluded that it may be adDisable to aDoid H7S solutions in
the CP6 prime, especially in patients 8ith an increased risk for
bleeding after cardiac operations4M
AR s'erior to E* as 4PB Prime
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%cta %naesthesiol Scand 599$ ul>'9$!?=
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ASERINGRinger’s acetate
First Line
Fluid Resuscitation Therapy
Man!aat lain dari ASERING
3 irekomendasikan oleh !5!+! untuk
pasien emam Berdarah engue
(B)!W.H.O. SEA Dept. of Communicable Disease. Regional Guidelines
on Dengue / DHF Pe!ention and Contoll. Regional Publ. "#. $###.
3 Pada stroke akut" pemberian 'S6789:
sesuai dengan konsep menghindari ';
.gS+4 sebanyak 10 " akan meningkatkan
tonisitas infus men>adi 8S+
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A,an di,unaan pada ana 5 $a-i7
2 $iindi*a!i*an untu &esusitasi ( misa'asus de/id&asi $e&at* S-% "
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• Rep'a+ement 9uid f%& &esus+itati%n ,ast&%ente&itis* $u&n*/em%&&/a,i+ s/%+* "SS
• Int&a%pe&ati.e
• P&imin, s%'uti%n f%&+a&di%pu'm%na&- $-pass (!P
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RES3SITASIRES3SITASI R3#ATANR3#ATAN
N3TRISIN3TRISI=&ista'%id=&ista'%id
Men,,anti e/i'an,an aut (/em%&&/a,e*
)I '%ss* &%n,,a e3#
Men,,anti e/i'an,an aut (/em%&&/a,e*
)I '%ss* &%n,,a e3#
C7 =e$utu/an n%&ma' (I12 u&in feses#7 "uun,an nut&isi
C7 =e$utu/an n%&ma' (I12 u&in feses#7 "uun,an nut&isi
TERAPI CAIRAN
K'idE'%*t'itE'%*t'it
Seri 2%07NSeri 2%07N
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7mbryo 9
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Rati%na'e %f maintenan+e
s%'uti%ns
Rati%na'e %f maintenan+e
s%'uti%ns
F'uid &edist&i$uti%n
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K%.utuhan haianM
Air 3050 m,/kgBB
Na= 2 me>/kgBBK = ( me>/kgBB
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Potassium Sodium
(mEq/kgBW/day) (mEq/kgBW/day)
Adult1
0.9 - 1.3 1.0 - 1.7
Fo i!"a!t to #$ild%!& ' as%d o! 100 ml o" at% "o %a#$ 100 k#al %*+%!d%d.
,ai!t%!a!#% %l%#t. %qui%m%!t ' 100 ml a!d &- mEq o" a a!d "o %%y 100 k#al %*+%!d%d.
u+ to 10 kg
11 - &0 kg
&0 kg
2aily Body Fluid &0 - 30 1.0
4om%ostasis3 (mi!imum) (mi!imum)
100 ml at% / kg
1000 ml 5 60 ml / kg "o %a#$ kg ao% 10 kg
1600 ml 5 &0 ml /kg "o %a#$ kg ao% &0 kg
Potassium Sodium
(mEq/kgBW/day) (mEq/kgBW/day)
Adult1
0.9 - 1.3 1.0 - 1.7
Fo i!"a!t to #$ild%!& ' as%d o! 100 ml o" at% "o %a#$ 100 k#al %*+%!d%d.
,ai!t%!a!#% %l%#t. %qui%m%!t ' 100 ml a!d &- mEq o" a a!d "o %%y 100 k#al %*+%!d%d.
u+ to 10 kg
11 - &0 kg
&0 kg
2aily Body Fluid &0 - 30 1.0
4om%ostasis3 (mi!imum) (mi!imum)
100 ml at% / kg
1000 ml 5 60 ml / kg "o %a#$ kg ao% 10 kg
1600 ml 5 &0 ml /kg "o %a#$ kg ao% &0 kg
1. Page C.P., Thomas C.H. and George M. Nutritional Assessment and Support. A primer 2nd Ed. P : 2. 1!!".
2. Martine#$%ian&hi, '., M(, Mi&helle, )P, M(., Mar* A.G., M(. Pediatri&s : 'omiting, (iarrhea, and (eh+dration in amil+
Pra&ti&e Hand-oo* rd Ed. /SA.
. 0o**o and Tannen. luid and Ele&trol+te rd Ed. % Saunders.
Pta!!iu, and Sdiu,H,%!ta!i! and $ai'5
R%ui%,%nt
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• Pe&'u men,eta/ui $e&apa e$utu/an ai&*e'et&%'it(Na*= #
• Pe&'u men,eta/ui status Nat&ium dan a'ium se&um
• Pe&'u men,eta/ui s-a&at e+epatan =
* dest&%sa*'ipid* AA
air 30-50 ml/kg; Na+
2 mEq/kg K +
1 mEq/kg
Na+ 135-145 mEq/L; K + 3,5-5 mEq/L
K + < 20 mEq/am!(5-10 mEq/am);"eks#r$sa
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A!a' LautanRu,atan
$i;ing,ar'tan Normal
*aline .Na= (51 mE>/,
,ar'tan
%l'kosa 5?
,ar'tan (/2 N* ,ar'tan (/3 N* ,ar'tan (/1 N* ,ar'tan (/5 N*
Na= 77 mE>/, Na= 5(mE>/, Na= 38 mE>/, Na= 3( mE>/,
,ar'tan KAEN ( A ,ar'tan KAEN 2 ,ar'tan KAEN 3 ,ar'tan KAEN 1
Suplementasi elektrolit Suplementasi air
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are still "idely used
!or maintenance therapy
#
RL
#
$% & 'tros
# $% & 'tr( in Ring rs
What a% th% i,+a&t! What a% th% i,+a&t!
9a&t!M9a&t!M
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Kebutuhan ir 2333 m* (* 2 * K-%) + 2 *
)atrium :3 133 m%? 23 m%? 133 m%?
Kalium .: m%? A m%? .3 m%?
In!us RL bukan
)ntuk Terapi Rumatan
Ilustrasi 66 #e8asa Org Indonesia! ? $* kg
*A+EN ,A *A+EN ,-
(ational infusion solution for maintenan5e therapy 6age E years7
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*A EN ,-
*A+EN .- (ational infusion solution for maintenan5e therapy 6age < years7
'nak BB ? 20 kg
Kebutuhan ir 1: * (* 1: * K-%) + , 1: *
)atrium 3 133 m%? 1B: m%? : m%?
Kalium 23 - :3 m%? m%? 3 m%?
In!us RL bukan
)ntuk Terapi Rumatan
7ef!
1! 7ie 5! luid
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7TAHU =E
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$ / / i
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C7 Menata e$utu/an /a&ian =a'ium?
C7 Menata e$utu/an /a&ian =a'ium?
i d S di
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Potassium Sodium
(mEq/kgBW/day) (mEq/kgBW/day)
Adult1
0.9 - 1.3 1.0 - 1.7
Fo i!"a!t to #$ild%!& ' as%d o! 100 ml o" at% "o %a#$ 100 k#al %*+%!d%d.
,ai!t%!a!#% %l%#t. %qui%m%!t ' 100 ml a!d &- mEq o" a a!d "o %%y 100 k#al %*+%!d%d.
u+ to 10 kg
11 - &0 kg
&0 kg
2aily Body Fluid &0 - 30 1.0
4om%ostasis3
(mi!imum) (mi!imum)
100 ml at% / kg
1000 ml 5 60 ml / kg "o %a#$ kg ao% 10 kg
1600 ml 5 &0 ml /kg "o %a#$ kg ao% &0 kg
Potassium Sodium
(mEq/kgBW/day) (mEq/kgBW/day)
Adult1
0.9 - 1.3 1.0 - 1.7
Fo i!"a!t to #$ild%!& ' as%d o! 100 ml o" at% "o %a#$ 100 k#al %*+%!d%d.
,ai!t%!a!#% %l%#t. %qui%m%!t ' 100 ml a!d &- mEq o" a a!d "o %%y 100 k#al %*+%!d%d.
u+ to 10 kg
11 - &0 kg
&0 kg
2aily Body Fluid &0 - 30 1.0
4om%ostasis3
(mi!imum) (mi!imum)
100 ml at% / kg
1000 ml 5 60 ml / kg "o %a#$ kg ao% 10 kg
1600 ml 5 &0 ml /kg "o %a#$ kg ao% &0 kg
1. Page C.P., Thomas C.H. and George M. Nutritional Assessment and Support. A primer 2nd Ed. P : 2. 1!!".
2. Martine#$%ian&hi, '., M(, Mi&helle, )P, M(., Mar* A.G., M(. Pediatri&s : 'omiting, (iarrhea, and (eh+dration in amil+
Pra&ti&e Hand-oo* rd Ed. /SA.
. 0o**o and Tannen. luid and Ele&trol+te rd Ed. % Saunders.
Pta!!iu, and Sdiu,H,%!ta!i! and $ai'5R%ui%,%nt
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POTASSI3# 93NCTIONPOTASSI3# 93NCTION
• T/e p&in+ipa' int&a+e''u'a& +ati%n
• Mem$&ane &ep%'a&iati%n• Neu&%:aut%n%mi+• Neu&%mus+u'a& e@+ita$i'it-
• )'-+%,en dep%siti%n 5 P&%teinmeta$%'ism• Re'ease %f pan+&eati+ /%&m%ne• Int&a+e''u'a& pH
Rena' Tu$u'a& A$s%&pti%n
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Rena' Tu$u'a& A$s%&pti%n
Na/
2 /
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Renal -'6'lar A6sortion
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Asupan = C0 me6/a&iAsupan = C0 me6/a&i
$%:!it Ku,u'ati 2?0-D00 ,E da'a, 7-0 hai
:annen R.$ Potassu0 Dsorders. In Ko11o H :annen. lud andEle+trolytes.
B Saunders Co0pany 7rd ed, pp #!7
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Hip%a'emiaHip%a'emia
• In!id%n! 20 +ada +a!i%n aat-ina+ (3S)
• Pada dia% ; ,a'nuti!i
• P%n5%.a. .%aia!i
• I,+'i*a!i +ada +%n5a*it *adia!*u'aMhi+%t%n!i" +t%n!i int*!i*a!i diita'i!" CABG
• P%,.%ian Inu! 5 ,%nandun *a'iu, 20,EL u,u,n5a di+%'u*an +ada +a!i%n aat-ina+
• In!id%n! 20 +ada +a!i%n aat-ina+ (3S)
• Pada dia% ; ,a'nuti!i
• P%n5%.a. .%aia!i
• I,+'i*a!i +ada +%n5a*it *adia!*u'aMhi+%t%n!i" +t%n!i int*!i*a!i diita'i!" CABG
• P%,.%ian Inu! 5 ,%nandun *a'iu, 20
,EL u,u,n5a di+%'u*an +ada +a!i%n aat-ina+
>an*er M. -ypo1ale0a. e0ed+ne.+o0Fe0er*Ftop+!47.ht0l
Mana,ement %f Se.e&e
Mana,ement %f Se.e&e
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,H-p%a'emia in /%spita'ied
Patients
,H-p%a'emia in /%spita'ied
Patients• JLL patients 4it/ Se&um = 3 3 mm%'2
at admissi%n
• (L7G# /ad n% su$se6uentmesu&ement %f p%tassium 'e.e's
• L0 (30G# 4e&e dis+/a&,ed 4it/su$n%&ma' p%tassium 'e.e'
2AMA Jol. #5# No. 8, Aprl !7,!""#
Inad%uat%&'ini&a' ,ana%,%nt
h *a'%,ia
H ' i di I d iH ' i di I d i
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H-p%a'emia di Ind%nesiaH-p%a'emia di Ind%nesia
• 2imitted in+iden+ep&e.a'en+e data (3 +ente&s#
• Insiden di RSPA" )at%t S%e$&%t%* $a,ianpen-ait da'am V L G
• Penin,atan tenden+- pasien &a4at inapden,an /ip%a'emia V C* G (saat masu
ps* dan saat e'ua& men>adi pasien#
• 2imitted in+iden+ep&e.a'en+e data (3 +ente&s#
• Insiden di RSPA" )at%t S%e$&%t%* $a,ianpen-ait da'am V L G
• Penin,atan tenden+- pasien &a4at inapden,an /ip%a'emia V C* G (saat masu
ps* dan saat e'ua& men>adi pasien#
Sudomo, Untung. Marissa Ira. The Indonesian ournal o!" #astroenterolog$, %e&atolog$
and Digestive 'ndosco&$. December ())*. +ol., -o.. /.0010().
C7 RSPA" )ATOT SOE
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H-p%a'emia di Ind%nesiaH-p%a'emia di Ind%nesia
• P&e.a'ens V G• Penin,atan tenden+- /-p%a'emia
pasien saat &a4at inap (saat masu
pasien* e'ua& men>adi 3B pasien#
• P&e.a'ens V G• Penin,atan tenden+- /-p%a'emia
pasien saat &a4at inap (saat masu
pasien* e'ua& men>adi 3B pasien#
D2oko 3idodo, 4udi Setia5an, 6hie 7hen, 8eonard -aenggolan, 3ida$at D2oko Santoso, The /revalence
%& '$kalemia in '$si#ali*e" #s i# .n&e#i$s iseases r$lem a# i#$angnksm$ '$si#al akar#a, Acta Medica Indonesiana +ol9, -o*, October ()):, &age ()(1()*.
7 SU
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H-p%a'emia di Ind%nesiaH-p%a'emia di Ind%nesia
• P&e.a'ens /-p%a'emia pts V 0 G• Penin,atan tenden+- /-p%a'emia
pasien saat &a4at inap (saat masu
0 pasien* e'ua& men>adi L pasien#
• P&e.a'ens /-p%a'emia pts V 0 G• Penin,atan tenden+- /-p%a'emia
pasien saat &a4at inap (saat masu
0 pasien* e'ua& men>adi L pasien#
-asronudin, %amidah, Ida 4agus 6risna, Suharto, 'dd$ Su5ando2o,
The &revalence o! %$&okalemia in In!ectious Diseases %os&itali;ed /atients, Medika +ol (
December ()):, &age"
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Men,apa /ip%a'emiau&an, dipe&/atian?
Men,apa /ip%a'emiau&an, dipe&/atian?
)e>a'a tida spesiQ dan umumn-a $a&umun+u' pada ada& = 3 mE62
Pada pasien n%n:a&dia tida dim%nit%& etat
Fasi'itas 2a$ tida memadai
A4a&eness
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"ep'esi a'ium >a&an, te&>adi
e&u ???
B%a+a Ban5a* K di+%'%h dai ,a*ana
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B%a+a Ban5a* K di+%'%h dai ,a*ana
Sa-u&an =entan,* $un+is 00 ,& =a+an, 000 ,&
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Ta*ut Hi+%*a'%,iad%nan +%,.%ian KAEN
KAEN3B mengan'ng kali'm (0 mE>/500 ml
KAEN3B mengan'ng kali'm (0 mE>/500 ml
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An/uanM 0 ,E/a,
g g >g g >
K%&%+atan Ru,atan ?00 ,'< /a,
Q 0 ,'/a, 20 t%t%!,%nit
atau Q "< ,E K
/a,
$a'a, +a*t%*M
Ri!i* Hi+%*a'%,ia ,ini,a'
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Ai d N Tid
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Ai& dan Na Tida
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P!t+%ati% #aint%nan&%
• M%st +%mm%n p&%$'em in p%st%pe&ati.e9uid $a'an+e is 9uid %.e&'%ad
• NS ma- a,,&a.ate 4ate& &etenti%n
• !u&&ent &e+%mmendati%n 2 9uidp%st%pe&ati.e'-W L0:C00 mE6 s%dium
• H-p%a'$uminemi+ patient ma- &e6ui&e'%4 s%dium
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•Edema pa&u $isa te&>adi da'am 3L >am pas+a $eda/ $i'a &etensi+ai&an me'e$i/i L m',d se$ain-a intae ai& 000 m'
•Pemu'i/an Fun,si sa'u&an +e&na 'e$i/ +epat pada e'%mp% pasien&esesi usus -an, mendapat +ai&an p%st%p 2W mE6 Nadi$andin,an e'%mp% K 3 2W C mE6 Na se$ain-a asupanNa pas+a $eda/ L0:C00 mE6
•Pasien /ip%a'$uminemia men,a'ami espansi +ai&an einte&stisia'* pem$e&ian nat&ium tin,,i men-e$a$an 'ua %pe&asi
su'it sem$u/
•Es&esi ai& dan nat&ium 'e$i/ 'am$at pada pasien p%st%p -an,mendapat +ai&an den,an andun,an nat&ium -an, 'e$i/ tin,,i
•=a'%&i minima' L00 +a' memi'ii efe men,/emat p&%tein(P&%tein:spa&in, e;e+t#
$. Aieff Allen . Fatal Postopeati!e Pulmona Edema. Pat(ogenesis 0 iteatue Re!ie'. CHES, $###1$$23$45$6$455
". obo D7 et al.Effect of salt and 'ate balance on eco!e of gastointestinal function afte electi!e colonic esection.
ancet "--" )a "2.42#824"-93$5#"64
4. Hill G.. Disodes of nutition and metabolism in clinical suge. C(uc(ill i!ingstone $##-
:. Fiona RE*D; Dileep 7. O
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ID F'uid O.e&'%adID F'uid O.e&'%adID F'uid O.e&'%adID F'uid O.e&'%ad
• "e+&ease mus+u'a& %@-,entensi%n and de'a- &e+%.e&- %f,ast&%intestina' fun+ti%n
• !ause ,ene&a' edema• Impede tissue /ea'in, and
+a&di%pu'm%na&- fun+ti%n
a nu & s a amp%pu'asi
http://www.emedicine.com/ped/topic2954.htm
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p p
Ind%nesia CBBJ TAR)ET +apita a'%&i 00 p&%tein
,mS=RT CBBJ a'%&i C0 p&%tein L,m
XO&an, Ind%nesia se$e'um >atu/sait
suda/ mende&ita deQsit nut&isi CG
8/18/2019 Otsuka Ipai 07.03.07
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sus boor" fistel usus-kulit
sus harus di-istirahatkan
9utrisi harus le#at ena (9P6)
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EDEMA ANASARKA + HEPATOMEGALI
8/18/2019 Otsuka Ipai 07.03.07
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HARUS
8/18/2019 Otsuka Ipai 07.03.07
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$- 4ei,/in, -%u& patients p&e and p%st%pe&ati.e'-?
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O& $- &,+aatin%6+%i%n&%d p&e and p%st%pe&ati.e'-?
I'ust&asi Rumatan PasaI'ust&asi Rumatan Pasa
8/18/2019 Otsuka Ipai 07.03.07
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am
(di$e&ian sete'a/ J >am pas+a $eda#
.$.-ll. Dsorders of Nutrton and Meta%ols0 n Cln+al Sur*ery. Chru+hll $/n*stone #33!, p 5"
ol Na 4l K = K&al
NS $**
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R2" R" Infus 'ain =AENM)3 Na/ )=* )9+ )** 5**
2 / ; ; '= +*2alori +** +** +** ;**
R2" R" Infus 'ain =AEN M)
Na
/
agak tinggi sangat tinggi sangat tinggi adekuat
2 / kurang kurang cukup adekuat
2alori kurang pas0pasan pas0pasan adekuat
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ASERIN) 5 =AEN 3
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ASERIN) 5 =AEN 3<%mpati$e' den,an %$atdi$a4a/ ini
• Nicholin
•Arental
•Sermion
•Aagamet
•Primperan
• Nicholin
•Arental
•Sermion
•Aagamet
•Primperan
•gSO+
• Neurobion
•Syntocinon
•%minophylline
•gSO+
• Neurobion
•Syntocinon
•%minophylline
*ntenal aboato Data 8BA O* Facto9
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PEMA=AIAN !AIRAN INFUS
"I RUMAH SA=IT
disesuaian den,an
sediaan infus -, ada dipasa&an
PE#AKAIAN IN93S $I 3G$
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S@O2 HIPOGOL7I2
A*ERIN%
2030 ml/kg/Cam
@a AI#%2
' tahun ' tahun
KAEN 1A KAEN (B2ecepatan? 66 5* kg? + ml.kg.Qam
550)* kg ? ) ml.kg.Qam
)$ kg ? 5 ml.kg4Qam
Contoh ? %nak $ tahun 66 5$ kg0
+ - 5* / ) - $ F
$* ml.Qam F 5) tetes.menit
Normo.hipo2 Normo.
hipo2
KAEN 1B KAEN 3B/$%3
ObserDasi.
monitor
nadi teraba
akral hangat
urine output /
kecepatan bisa
diturunkan 5*
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P'S869 SD+;
Asering TRIF2UI"
Tae /%me messa,es
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C7 Ase&in, (AR# is an a'te&nati.e t% 2RNS as &esus+itati%n 9uid7Fu&t/e& pu$'i+ati%n* su+/ maintain pe&i%pe&ati.e +%&e temp*maintenan+e f%& dia$etes et%a+id%sis* int&a: %pe&ati.e 9uid
t/e&ap- in .a&i%us su&,i+a' settin,s* !P
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TERI#ATERI#A
Te&ima =asi/
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PLAS#A NaC' 0
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D > A m%?@*
)a8 > 1:. m%?@*
Cl- > 1:. m%?@*
&0D > 3 m%?@*1 liter 1 liter
PLAS#A NaC' 0
&0D 9 A
Plasma NaCl 0.9%
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PLAS#A NaC' 0
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D > A m%?@*
)a8 > 1:. m%?@*
Cl- > 1:. m%?@*
&0D > 3 m%?@*1 liter 1 liter
PLAS#A NaC' 0
&0D 9 A
Plasma NaCl 0.9%
ASI$OSIS HIPERKLORE#IK AKIBAT
Pada SS" ;' pemberian 9aCl 0!/= dalam>umlah besar bisa menyebabkan asidosis
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'ite&
PE#BERIAN LAR3TAN Na C' 0
<
&0D 9 1B sidosis
)a8 > 61.381:.7@2 m%?@*> 1. m%?@*
Cl- > 61328 1:.7@2 m%?@*> 12A m%?@*
&0D > 1B m%?@*
Plasma
> y
hiperkloremik
PLAS#A Lautan RINGER ASETAT
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D> A m%?@*
Cation8 > 1 m%?@*
Cl- > 13B m%?@*
setat- > 2A m%?@*
&0D > 3 m%?@*
C'ite&
C'ite&
PLAS#A Lautan RINGER ASETAT
&0D 9 A
Plasma Ringer AsetatAsetat cepat
dimetabolisme
RINGER ASETAT
(0)$%( &%!! garis pertama dalam resusitasi 5airan pada diare dgdehidrasi berat,DD dan DK
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'ite&
<
RINGER ASETAT
&0D 9 . lebih alkalosis dibanding Fika
diberikan )aCl 3B;
)a8 > 61.3817@2 m%?@*> 1B m%?@*
Cl- > 61328 13B7@2 m%?@* > 13: m%?@*
setat- 6termetabolisme7 > 3 m%?@*
&0D > . m%?@*
Plasma
PLAS#A Lautan N2-$?
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D> A m%?@*
Cation8 > m%?@*
Cl- > m%?@*
&0D > 3 m%?@*
C'ite&
C'ite&
PLAS#A Lautan N2-$?
&0D 9 A
Plasma N2/D5
N,a' +H !%t%'ah +%,.%ian
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'ite&
<
+ +N2$?
&0D 9 1B lebih asidosis dibanding Fika
diberikan (
)a8 > 61.387@2 m%?@*> 13A: m%?@*
Cl- > 61328 7@2 m%?@* > AB: m%?@*
*aktat- 6termetabolisme7 > 3 m%?@*
&0D > 1B m%?@*
Plasma
PLAS#A Lautan R SOL
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)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D> A m%?@*
)a88K88Ca88 > 1:. m%?@*
Cl- > 1::: m%?@*
&0D > -1: m%?@*
C'ite&
C'ite&
PLAS#A Lautan RSOL
&0D 9 A
Plasma R.Sol
8/18/2019 Otsuka Ipai 07.03.07
124/126
PLAS#A Lautan KAENDB
8/18/2019 Otsuka Ipai 07.03.07
125/126
)a8 > 1.3 m%?@*
Cl- > 132 m%?@*
&0D> A m%?@*
Cation8 > 3 m%?@*
Cl- > :3 m%?@*
*aktat- > 23 m%?@*
&0D > 3 m%?@*
C'ite&
C'ite&
PLAS#A Lautan KAENDB
&0D 9 A
Plasma KAEN3BLaktat cepat
dimetabolisme
N,a' +H !%t%'ah +%,.%ian
8/18/2019 Otsuka Ipai 07.03.07
126/126
'ite&
<
+ +KAENDB
Cation > 61.3837@2 m%?@*> 13: m%?@*
Cl- > 61328 :37@2 m%?@* > m%?@*
*aktatt- 6termetabolisme7 > 3 m%?@*
&0D > 2B m%?@*
Plasma