ORG 2969 HAS OC POTENTIAL

Or a 2969 (Organon) is a new progestational preparation.

wh ich has potential application as a cc neacepuve agent. Thedrug was givenin daily doses of60~ for 21 days to 5 women.aJI with a previousl y reg ular bleeding pattern. No volunteerovu lated duri ng treatmen t. as judged by daily determinations of

FSH, tH , progesterone and oestrogen plasma levels.Thecha racteristic mid-cycle FS H and LH peaks failed to appear ,and prog esterone was almost total ly suppressed. Oest roge nshowed a mid-cycle peak . as in cont rols, but it feJllater and 3 of

5 volunteers had increased plasma levels. There werechangesin cervical mu cus and vaginal cyto logy , with the q uantity.

appearance and spinnbarkei l of the mucus beins similar to thatin the luteal phase o f the control period. Sperm penetration did

not tilJ,:e place in vnro.

Stouby.S_O.:~ 14, S29(No . S, I9161

INPHARMA 22r>d January , 1971 P8